No definition available.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519972 |
1. Apply sex-specific ruleNone |
519972 |
2. Check conditionsNone |
519972 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
243 |
4. Check minimum number of eventsNone |
243 |
5. Include endpointsNone |
243 |
6. Filter based on genotype QC (FinnGen only) |
237 |
Control definitions (FinnGen only)
- Control exclude
- L12_DISORDSKINAPPENDIX
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- L60
- Name in latin
- Onycholysis
Similar endpoints
↥List of similar endpoints to
Onycholysis
based on the number of shared cases.
Similar with more cases:
- Nail disorders
- Disorders of skin appendages
- Diseases of the skin and subcutaneous tissue
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1667 | 990 | 666 |
| Only index persons | 1526 | 920 | 606 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.02 | 0.03 | 0.02 |
| Only index persons | 0.03 | 0.03 | 0.02 |
| Median age at first event (years) | |||
| Whole population | 44.88 | 48.31 | 39.98 |
| Only index persons | 46.36 | 49.26 | 41.97 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 237 | 163 | 74 |
| Unadjusted period prevalence (%) | 0.05 | 0.06 | 0.03 |
| Median age at first event (years) | 53.74 | 50.99 | 59.79 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 243
- Matched controls
- 2430
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
L60.1
ICD-10 Finland
Onycholysis
16384.0
307.7
241
7
L60.0
ICD-10 Finland
Ingrowing nail
7.4
20.1
31
47
L60.9
ICD-10 Finland
Nail disorder, unspecified
16.0
13.9
22
15
D01AE16
ATC
amorolfine; topical
3.3
9.7
40
136
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.3
9.3
119
714
QDH01
NOMESCO Finland
Excision of nail bed in toe
51.9
8.7
10
*
S22
ICPC
Nail symptom/complaint
3.7
8.5
28
82
D07AD01
ATC
clobetasol; topical
2.6
7.6
50
220
D01BA02
ATC
terbinafine; oral
2.3
7.6
70
360
B35.1
ICD-10 Finland
Tinea unguium
3.6
7.3
25
75
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
2.1
7.2
93
546
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
3.0
6.6
30
108
L60.3
ICD-10 Finland
Nail dystrophy
71.7
6.5
7
*
L60.8
ICD-10 Finland
Other nail disorders
11.5
6.4
11
10
ZXA05
NOMESCO Finland
Left side
2.2
6.2
66
357
L03.0
ICD-10 Finland
Cellulitis of finger and toe
2.9
6.1
29
107
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
158
1178
1.98
5.91
10.2
9.4
3.96
3.95
e9/l
0.01
136
1023
29
116
2.70
5.27
4.4
3.4
4.65
4.52
pmol/l
0.24
21
108
43
208
2.30
5.25
2.7
3.0
5.52
7.41
umol/l
0.58
38
175
31
132
2.55
4.98
15.5
8.3
11.45
8.28
mmol/l
1.38
31
126
29
120
2.61
4.94
1.9
1.5
—
—
—
0
0
192
1597
1.96
4.44
5.5
3.9
14.55
14.67
pmol/l
0.25
168
1461
127
939
1.74
4.32
11.3
6.8
1.22
1.22
mmol/l
0.22
114
803
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
14
42
3.48
4.11
2.6
4.5
0.37
0.35
u/ml
—
8
24
71
449
1.82
4.10
2.5
2.2
2.46
3.00
mg/l
2.35
61
380
52
298
1.95
4.06
3.4
2.3
1.58
0.94
e6/l
0.30
33
170
104
739
1.71
4.00
2.1
1.8
97.75
98.30
pmol/l
0.04
47
352
216
1897
2.25
3.96
6.4
4.7
1.87
1.85
mu/l
0.07
194
1748
109
788
1.69
3.91
7.5
4.4
35.38
36.14
g/l
0.70
104
746
25
108
2.47
3.91
2.7
2.3
281.21
107.34
ng/l
0.95
25
91
185
1550
1.81
3.79
10.3
7.1
84.99
76.61
u/l
1.19
175
1455
116
858
1.67
3.78
10.4
6.2
1.22
1.22
mmol/l
0.10
110
790
15
50
3.13
3.76
3.2
1.8
222.33
239.33
ug/l
0.06
15
43
43
237
1.99
3.74
3.7
2.4
21.28
23.36
%
0.53
37
203
21
86
2.58
3.66
5.1
7.0
24.62
24.19
mmol/l
0.22
21
86
48
278
1.91
3.62
6.5
3.5
0.81
0.82
mmol/l
0.23
43
266
48
278
1.91
3.62
3.4
2.5
20.13
2.78
e6/l
0.43
29
153
95
673
1.68
3.61
5.1
2.8
—
—
—
0
0
25
115
2.31
3.42
9.6
3.5
0.37
1.99
mmol/l
1.51
18
81
76
517
1.68
3.33
4.5
2.6
0.28
0.36
e6/l
0.29
54
383
57
359
1.77
3.28
1.4
1.3
11.97
10.21
u/ml
0.08
18
145
133
1046
1.60
3.22
6.6
6.1
10.06
10.73
umol/l
0.44
126
988
65
429
1.70
3.16
1.6
1.4
21.14
20.93
nmol/l
0.04
52
353
12
35
3.55
3.15
1.8
3.8
50.67
58.80
%
1.06
12
35
34
187
1.95
2.98
2.2
2.3
25.56
29.24
u/l
0.64
27
153
87
633
1.58
2.85
4.9
3.5
2.35
2.36
mmol/l
0.12
71
565
11
33
3.44
2.85
1.8
3.5
3.20
4.97
e9/l
1.93
11
33
106
816
1.53
2.67
3.7
2.3
77.33
76.42
nmol/l
0.12
96
722
42
257
1.77
2.65
2.3
1.7
—
—
—
0
0
108
840
1.51
2.57
14.6
11.3
1.21
1.20
inr
0.04
28
272
12
45
2.75
2.49
1.5
1.2
—
—
—
0
0
83
620
1.51
2.35
2.7
2.5
53.81
57.13
u/l
0.46
75
572
138
1145
1.47
2.30
5.9
4.9
6.53
6.55
mmol/l
0.03
133
1066
65
462
1.56
2.30
3.1
2.1
—
—
—
0
0
5
9
5.64
2.22
1.6
1.6
—
—
—
0
0
12
48
2.58
2.22
2.2
1.1
—
—
—
0
0
34
207
1.75
2.19
7.2
7.3
103.29
104.29
mmol/l
0.56
34
207
110
887
1.44
2.06
3.3
2.7
119.39
99.26
ug/l
0.66
103
818
6
15
4.07
2.05
1.3
1.2
—
—
—
0
0
7
21
3.40
1.98
1.3
1.2
—
—
—
0
0
6
16
3.82
1.94
1.0
1.1
—
—
—
0
0
161
1403
1.44
1.91
3.8
2.9
48.73
41.93
u/l
0.46
150
1325
23
130
1.85
1.89
1.3
1.3
72.05
352.21
u/ml
0.87
23
117
87
682
1.43
1.86
3.3
3.2
32.05
31.75
u/l
0.04
82
646
45
309
1.56
1.84
2.0
1.7
1075.05
1255.97
nmol/l
0.66
33
236
14
67
2.16
1.80
2.5
2.1
—
—
—
0
0
28
172
1.71
1.76
2.0
1.5
—
—
—
0
0
28
173
1.70
1.73
2.0
1.6
—
—
—
0
0
221
2073
1.73
1.68
22.1
13.7
3.93
3.95
mmol/l
0.51
215
2016
58
429
1.46
1.67
1.9
1.9
1.74
0.98
mg/l
0.47
45
327
29
183
1.66
1.67
3.4
3.2
—
—
—
0
0
66
501
1.44
1.66
1.6
1.3
0.52
1.47
u/ml
1.58
14
150
206
1902
1.55
1.65
16.7
11.3
81.75
84.41
ml/min/173m2
0.85
179
1529
12
56
2.20
1.64
1.2
1.3
—
3.39
—
0
10
5
14
3.62
1.62
1.4
1.1
—
—
—
0
0
158
1394
1.38
1.60
3.2
3.3
—
—
—
0
0
220
2067
1.68
1.58
21.1
12.0
25.19
21.80
mg/l
0.72
195
1577
220
2067
1.68
1.58
21.9
13.6
139.14
139.78
mmol/l
2.80
214
2014
35
237
1.56
1.53
5.2
4.1
32.88
32.07
%
0.17
25
152
13
65
2.06
1.51
2.2
1.9
—
—
—
0
0
13
66
2.02
1.46
1.3
2.3
—
—
—
0
0
16
88
1.88
1.45
2.3
1.5
—
—
—
0
0
5
16
3.17
1.44
2.0
2.8
—
—
—
0
0
5
16
3.17
1.44
1.0
1.7
—
—
—
0
0
168
1509
1.37
1.44
5.6
4.0
14.48
10.72
mm/h
1.93
156
1395
20
119
1.74
1.43
1.2
1.3
31.65
27.25
iu/l
0.17
13
97
12
60
2.05
1.40
1.1
1.2
—
—
—
0
0
47
347
1.44
1.37
5.1
3.0
218.22
207.28
ng/l
0.02
36
248
8
34
2.40
1.30
1.3
1.4
—
—
—
0
0
23
147
1.62
1.28
1.3
1.3
47.17
173.14
iu/ml
—
6
61
59
462
1.37
1.23
3.5
2.6
323.71
9361.26
umol/l
2.89
48
404
5
19
2.66
1.22
1.0
1.1
—
—
—
0
0
235
2278
1.96
1.19
28.5
18.2
258.31
254.72
e9/l
0.34
229
2223
235
2278
1.96
1.19
28.6
18.2
39.55
40.21
%
1.02
221
2156
48
367
1.38
1.16
1.3
1.3
12.08
32.25
iu/ml
—
10
120
5
20
2.53
1.15
1.0
1.2
—
—
—
0
0
5
20
2.53
1.15
2.4
1.2
—
—
—
0
0
8
41
1.98
1.10
1.6
1.2
—
—
—
0
0
235
2280
1.93
1.07
28.7
18.2
4.41
4.50
e12/l
1.82
228
2220
26
180
1.50
1.06
6.8
9.6
2.40
1.23
mmol/l
1.49
21
147
61
495
1.31
1.00
3.9
3.0
1619.72
953.70
ng/l
0.65
48
409
9
49
1.87
1.00
1.3
1.2
—
—
—
0
0
5
23
2.20
0.98
1.8
1.5
—
—
—
0
0
5
23
2.20
0.98
1.8
1.5
—
—
—
0
0
5
23
2.20
0.98
1.8
1.5
—
—
—
0
0
5
23
2.20
0.98
1.8
1.5
—
—
—
0
0
5
23
2.20
0.98
2.4
1.3
—
—
—
0
0
5
23
2.20
0.98
1.8
1.5
—
—
—
0
0
7
36
1.97
0.98
1.9
1.1
—
—
—
0
0
7
36
1.97
0.98
1.9
1.1
—
—
—
0
0
9
51
1.79
0.95
1.9
2.1
—
—
—
0
0
9
51
1.79
0.95
1.1
1.9
—
—
—
0
0
32
239
1.39
0.90
1.5
2.0
—
—
—
0
0
6
29
2.10
0.90
5.8
3.0
20.83
69.99
u/ml
—
6
29
6
29
2.10
0.90
1.5
1.4
—
—
—
0
0
109
964
1.24
0.88
3.9
3.5
0.00
0.01
estimate
0.50
23
193
47
375
1.31
0.88
1.4
1.4
—
—
—
0
0
6
30
2.02
0.87
2.2
1.5
—
—
—
0
0
12
72
1.70
0.87
2.3
1.6
—
—
—
0
0
18
121
1.53
0.85
1.1
1.3
—
—
—
0
0
106
937
1.23
0.85
3.2
2.5
—
—
—
0
0
47
377
1.31
0.84
1.7
1.8
417.60
440.49
pmol/l
0.27
35
320
18
122
1.51
0.83
1.1
1.0
—
—
—
0
0
5
24
2.11
0.75
1.8
1.5
—
—
—
0
0
5
26
1.94
0.71
1.2
1.2
—
—
—
0
0
7
41
1.73
0.70
2.3
1.4
—
—
—
0
0
108
973
1.20
0.69
3.9
3.5
0.18
0.02
estimate
0.42
17
176
7
44
1.61
0.65
2.3
1.4
—
—
—
0
0
64
552
1.22
0.64
1.8
1.7
1.34
1.34
mmol/l
0.02
48
478
26
200
1.34
0.64
3.5
4.4
22.59
40.99
ug/l
0.20
19
165
106
961
1.18
0.61
5.3
4.7
0.00
0.01
estimate
0.50
22
184
33
267
1.27
0.58
1.7
2.1
—
—
—
0
0
190
1818
1.21
0.55
6.1
5.3
40.25
39.45
mmol/mol
0.41
173
1704
10
66
1.54
0.53
1.1
1.2
—
—
—
0
0
10
66
1.54
0.53
1.1
1.2
—
—
—
0
0
14
100
1.42
0.53
1.7
1.2
—
—
—
0
0
17
129
1.34
0.47
1.2
1.3
—
25.48
—
0
9
200
1934
1.19
0.45
4.8
4.3
5.87
5.85
mmol/l
0.05
180
1780
77
699
1.15
0.42
3.4
3.4
29.40
31.53
ng/l
0.09
54
447
5
33
1.53
0.41
1.8
1.2
—
—
—
0
0
16
204
0.77
0.41
1.4
1.7
—
—
—
0
0
0
18
0.00
0.40
0.0
1.6
—
4.88
—
0
8
5
35
1.44
0.39
2.6
1.4
—
—
—
0
0
0
19
0.00
0.39
0.0
1.4
—
—
—
0
0
8
111
0.71
0.38
1.6
1.8
—
—
—
0
0
5
37
1.36
0.37
1.8
1.5
—
—
—
0
0
27
228
1.21
0.35
2.9
3.0
0.89
0.76
ug/l
0.41
20
132
58
526
1.13
0.33
4.8
3.6
34.88
6.36
mg/mmol
2.14
37
314
34
300
1.16
0.28
3.4
4.6
25.88
21.63
%
0.91
18
139
8
64
1.26
0.27
1.1
1.8
—
—
—
0
0
13
159
0.81
0.25
3.2
2.8
50.87
70.94
ml/min/173m2
—
8
63
6
81
0.73
0.24
1.7
1.4
—
—
—
0
0
37
333
1.13
0.24
3.6
2.7
2.44
2.45
mmol/l
0.18
32
300
5
39
1.29
0.23
2.2
1.3
—
—
—
0
0
5
41
1.22
0.22
1.8
1.4
—
—
—
0
0
185
1808
1.10
0.22
22.4
14.9
14.11
14.69
%
1.03
185
1789
0
11
0.00
0.21
0.0
2.0
—
—
—
0
0
0
10
0.00
0.21
0.0
2.1
—
—
—
0
0
0
10
0.00
0.21
0.0
2.1
—
—
—
0
0
0
12
0.00
0.21
0.0
1.0
—
—
—
0
0
0
12
0.00
0.21
0.0
1.1
—
86.33
—
0
12
0
12
0.00
0.21
0.0
1.3
—
—
—
0
0
11
89
1.25
0.21
6.4
5.1
0.55
0.69
%
0.68
11
89
5
43
1.17
0.21
1.2
2.1
0.00
0.00
g/l
—
5
43
5
43
1.17
0.21
1.2
2.1
0.00
0.00
g/l
—
5
43
6
48
1.26
0.20
1.0
1.2
—
50.96
—
0
5
0
14
0.00
0.20
0.0
1.1
—
1.10
—
0
5
6
49
1.23
0.20
1.2
2.6
44.13
64.83
mg/l
—
6
40
6
49
1.23
0.20
1.2
2.7
28.03
29.23
mg/l
—
6
39
47
435
1.10
0.19
1.4
1.5
—
—
—
0
0
193
1897
1.08
0.17
4.4
3.8
1.22
1.27
mmol/l
0.73
173
1756
11
92
1.20
0.16
6.4
5.0
1.55
1.19
%
0.87
11
92
11
92
1.20
0.16
1.2
2.3
46.36
41.70
u/l
0.29
11
83
5
46
1.09
0.09
1.2
2.1
0.00
0.00
g/l
—
5
46
21
227
0.92
0.09
6.2
6.1
—
—
—
0
0
6
54
1.11
0.09
1.5
1.2
—
—
—
0
0
7
64
1.10
0.08
1.7
1.5
—
—
—
0
0
7
80
0.87
0.07
1.4
1.7
—
—
—
0
0
7
85
0.82
0.07
1.3
1.4
—
—
—
0
0
203
2015
1.05
0.06
5.2
4.7
2.83
2.84
mmol/l
0.05
180
1869
199
1976
1.04
0.05
4.9
4.2
1.49
1.51
mmol/l
0.36
175
1832
200
1988
1.03
0.04
4.9
4.2
4.75
4.78
mmol/l
0.20
181
1856
53
521
1.02
0.02
4.8
3.7
0.00
0.01
estimate
0.50
20
185
11
104
1.06
0.01
3.7
8.0
1.21
1.52
%
0.70
11
104
76
754
1.01
0.00
4.2
3.6
—
—
—
0
0
14
141
0.99
0.00
1.8
1.9
—
—
—
0
0
10
104
0.96
0.00
3.8
8.2
0.72
0.70
%
—
10
104
0
5
0.00
0.00
0.0
1.6
—
—
—
0
0
0
5
0.00
0.00
0.0
3.4
—
67.44
—
0
5
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
5.76
—
0
5
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.5
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint L12_NAIL_LYSIS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_NAIL_LYSIS | 1.582 [1.07, 2.33] | 0.02 |
| Birth year | 0.995 [0.99, 1.0] | 0.282 |
During the follow-up period (1.1.1998 — 31.12.2019), 73 out of 827 females with L12_NAIL_LYSIS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_NAIL_LYSIS | 1.692 [1.09, 2.62] | 0.018 |
| Birth year | 0.985 [0.98, 0.99] | 0.003 |
During the follow-up period (1.1.1998 — 31.12.2019), 70 out of 543 males with L12_NAIL_LYSIS died.
Mortality risk
Mortality risk for people of age
years, who have L12_NAIL_LYSIS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.189% | 0.308% |
| 5 | 0.914% | 1.598% |
| 10 | 2.268% | 4.152% |
| 15 | 4.445% | 7.92% |
| 20 | 7.88% | 13.34% |
Relationships between endpoints
↥Index endpoint: L12_NAIL_LYSIS – Onycholysis
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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