No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
230 |
4. Check minimum number of eventsNone |
230 |
5. Include endpointsNone |
230 |
6. Filter based on genotype QC (FinnGen only) |
230 |
Control definitions (FinnGen only)
- Control exclude
- L12_DISORDSKINAPPENDIX
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- L60
- Name in latin
- Onycholysis
Similar endpoints
↥List of similar endpoints to
Onycholysis
based on the number of shared cases.
Similar with more cases:
- Nail disorders
- Disorders of skin appendages
- Diseases of the skin and subcutaneous tissue
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1667 | 990 | 666 |
| Only index persons | 1526 | 920 | 606 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.02 | 0.03 | 0.02 |
| Only index persons | 0.03 | 0.03 | 0.02 |
| Median age at first event (years) | |||
| Whole population | 44.88 | 48.31 | 39.98 |
| Only index persons | 46.36 | 49.26 | 41.97 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 230 | 159 | 71 |
| Unadjusted period prevalence (%) | 0.05 | 0.05 | 0.03 |
| Median age at first event (years) | 52.56 | 50.80 | 56.51 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 198
- Matched controls
- 1978
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
L60.1
ICD-10 Finland
Onycholysis
4503599627370496.0
272.5
196
*
L60.9
ICD-10 Finland
Nail disorder, unspecified
16.8
11.0
17
11
QDH01
NOMESCO Finland
Excision of nail bed in toe
+∞
10.5
10
*
L60.0
ICD-10 Finland
Ingrowing nail
7.4
10.3
24
36
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.5
8.4
96
548
D01BA02
ATC
terbinafine; oral; topical
2.6
7.1
61
294
L60.3
ICD-10 Finland
Nail dystrophy
72.1
6.5
7
*
S22
ICPC
Nail symptom/complaint
4.8
6.4
20
45
L60.8
ICD-10 Finland
Other nail disorders
18.8
6.3
9
5
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
150
1117
1.99
5.68
10.1
9.4
3.9
3.9
e9/l
0.01
127
970
42
198
2.37
5.47
2.4
2.8
5.5
7.2
umol/l
0.49
37
168
29
114
2.77
5.46
1.9
1.4
—
—
—
0
0
28
110
2.76
5.28
4.5
3.3
4.5
4.5
pmol/l
0.06
20
103
30
125
2.61
5.05
15.9
7.6
11.7
8.3
mmol/l
1.51
30
119
122
885
1.81
4.64
11.1
6.5
1.2
1.2
mmol/l
0.07
110
759
112
805
1.76
4.29
10.1
6.0
1.2
1.2
mmol/l
0.06
106
740
106
751
1.76
4.26
7.0
4.3
35.3
36.1
g/l
0.74
101
708
101
706
1.77
4.25
2.1
1.8
98.5
98.8
pmol/l
0.02
47
341
181
1509
1.94
4.10
5.5
3.9
14.5
14.7
pmol/l
0.40
158
1385
92
632
1.76
4.07
5.3
2.9
—
—
—
0
0
24
101
2.54
3.97
9.0
3.4
0.4
2.0
mmol/l
1.36
17
73
177
1471
1.88
3.97
10.0
7.1
84.7
76.5
u/l
1.12
167
1380
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
13
38
3.57
3.96
2.7
4.8
0.4
0.4
u/ml
—
7
22
46
256
2.00
3.93
6.5
3.4
0.8
0.8
mmol/l
0.21
41
244
50
287
1.95
3.91
3.5
2.4
1.6
0.9
e6/l
0.31
31
165
12
34
3.67
3.82
1.8
3.9
50.7
59.0
%
1.09
12
34
24
103
2.49
3.82
2.8
2.3
290.5
98.8
ng/l
1.03
24
87
74
485
1.78
3.81
4.5
2.6
0.3
0.4
e6/l
0.40
52
359
41
222
2.03
3.77
3.8
2.2
21.3
23.5
%
0.54
36
191
67
428
1.80
3.75
2.5
2.2
2.4
3.0
mg/l
2.66
57
363
46
267
1.90
3.46
3.5
2.5
21.6
2.8
e6/l
0.43
27
148
11
32
3.56
3.38
1.8
3.5
3.2
5.0
e9/l
1.92
11
32
203
1797
2.10
3.36
6.5
4.7
1.9
1.9
mu/l
0.08
181
1659
56
352
1.78
3.27
1.4
1.3
12.0
10.7
u/ml
0.06
18
144
14
49
2.98
3.25
3.1
1.7
235.4
210.2
ug/l
0.09
14
42
62
405
1.73
3.16
1.7
1.4
20.6
20.8
nmol/l
0.03
49
335
126
988
1.61
3.13
6.0
6.0
10.1
10.3
umol/l
0.09
119
934
12
41
3.03
2.90
1.5
1.2
—
—
—
0
0
83
601
1.60
2.81
4.8
3.3
2.3
2.4
mmol/l
0.18
64
532
12
42
2.96
2.79
2.2
1.1
—
—
—
0
0
102
779
1.56
2.72
3.7
2.3
77.5
76.0
nmol/l
0.20
93
693
81
587
1.59
2.72
2.5
2.5
53.7
55.3
u/l
0.25
73
540
32
180
1.90
2.64
2.2
2.3
26.1
29.7
u/l
0.60
26
147
63
435
1.62
2.56
3.1
2.1
—
—
—
0
0
5
9
5.65
2.22
1.6
1.6
—
—
—
0
0
7
19
3.77
2.17
1.3
1.2
—
—
—
0
0
65
472
1.53
2.10
1.6
1.3
0.5
1.5
u/ml
1.58
13
143
197
1794
1.68
2.05
16.7
11.2
81.6
84.2
ml/min/173m2
0.84
174
1435
14
63
2.30
2.05
2.5
2.0
—
—
—
0
0
6
15
4.08
2.05
1.0
1.1
—
—
—
0
0
6
15
4.08
2.05
1.3
1.2
—
—
—
0
0
196
1784
1.67
2.03
19.4
13.1
39.1
40.2
%
1.14
150
1358
38
245
1.66
2.01
2.4
1.7
—
—
—
0
0
26
150
1.83
2.01
6.3
4.9
2.5
1.9
mmol/l
0.31
21
128
22
121
1.90
1.96
1.4
1.3
71.4
370.1
u/ml
0.87
22
110
43
289
1.60
1.93
2.0
1.7
989.8
1247.7
nmol/l
1.16
31
223
103
837
1.42
1.83
3.4
2.7
123.9
100.1
ug/l
0.78
96
774
5
12
4.23
1.83
2.0
3.2
—
—
—
0
0
35
228
1.63
1.79
5.2
4.1
33.1
32.0
%
0.23
24
146
13
61
2.20
1.75
2.2
1.8
—
—
—
0
0
20
111
1.88
1.75
1.2
1.3
31.7
26.4
iu/l
0.20
13
89
5
13
3.91
1.72
1.4
1.2
—
—
—
0
0
161
1426
1.43
1.69
5.7
4.0
14.8
10.8
mm/h
1.97
149
1318
209
1959
1.73
1.62
21.9
13.6
3.9
4.0
mmol/l
0.61
203
1903
151
1328
1.40
1.61
3.2
3.3
—
—
—
0
0
12
57
2.17
1.58
1.1
1.2
—
—
—
0
0
27
170
1.67
1.57
3.6
3.2
—
—
—
0
0
5
15
3.38
1.53
1.0
1.7
—
—
—
0
0
150
1324
1.38
1.53
3.7
3.0
47.4
42.4
u/l
0.29
140
1252
208
1953
1.68
1.52
21.7
13.6
139.1
139.8
mmol/l
2.74
202
1901
13
65
2.06
1.52
1.3
2.4
—
—
—
0
0
208
1954
1.67
1.50
21.1
11.9
25.8
22.1
mg/l
0.75
185
1496
57
431
1.43
1.48
3.6
2.6
320.6
9266.1
umol/l
2.66
46
374
5
17
2.98
1.36
1.0
1.1
—
—
—
0
0
80
651
1.35
1.33
2.8
3.2
32.2
31.0
u/l
0.16
75
617
45
333
1.44
1.31
5.1
3.0
230.7
213.2
ng/l
0.03
34
237
8
34
2.40
1.30
1.3
1.4
—
—
—
0
0
5
18
2.82
1.29
1.0
1.2
—
—
—
0
0
5
19
2.67
1.22
2.4
1.2
—
—
—
0
0
47
358
1.39
1.17
1.3
1.3
12.3
33.1
iu/ml
—
9
117
52
403
1.38
1.17
1.7
1.9
1.9
0.9
mg/l
0.56
40
304
59
468
1.35
1.15
3.8
3.0
1665.8
970.2
ng/l
0.65
46
391
5
21
2.41
1.09
1.8
1.5
—
—
—
0
0
5
21
2.41
1.09
1.8
1.5
—
—
—
0
0
5
21
2.41
1.09
1.8
1.5
—
—
—
0
0
5
21
2.41
1.09
1.8
1.5
—
—
—
0
0
5
21
2.41
1.09
2.4
1.3
—
—
—
0
0
5
21
2.41
1.09
1.8
1.5
—
—
—
0
0
12
67
1.83
1.07
2.3
1.6
—
—
—
0
0
5
22
2.30
1.04
1.8
1.5
—
—
—
0
0
9
48
1.91
1.01
1.3
1.2
—
—
—
0
0
9
49
1.87
1.00
1.1
1.9
—
—
—
0
0
18
117
1.58
0.97
1.1
1.0
—
—
—
0
0
24
168
1.48
0.94
2.1
1.5
—
—
—
0
0
24
168
1.48
0.94
2.2
1.6
—
—
—
0
0
102
892
1.26
0.94
4.4
4.0
—
—
—
0
0
6
28
2.17
0.92
2.2
1.5
—
—
—
0
0
6
29
2.10
0.90
1.5
1.4
—
—
—
0
0
14
87
1.65
0.90
2.4
1.5
—
—
—
0
0
44
352
1.31
0.81
1.4
1.4
—
—
—
0
0
6
34
1.78
0.77
1.8
1.1
—
—
—
0
0
6
34
1.78
0.77
1.8
1.1
—
—
—
0
0
102
911
1.21
0.73
4.1
3.5
0.0
0.0
estimate
0.00
21
168
5
25
2.02
0.73
1.2
1.2
—
—
—
0
0
5
26
1.94
0.71
6.0
3.0
19.2
75.0
u/ml
—
5
26
30
234
1.32
0.67
1.6
2.0
—
—
—
0
0
23
172
1.37
0.67
6.0
9.9
1.9
1.3
mmol/l
0.62
18
138
61
523
1.23
0.65
1.8
1.6
1.3
1.3
mmol/l
0.03
45
456
25
191
1.35
0.64
2.8
4.3
23.3
43.1
ug/l
0.20
18
156
43
356
1.26
0.62
1.7
1.7
425.6
444.1
pmol/l
0.18
31
304
102
923
1.19
0.62
4.2
3.5
0.2
0.0
estimate
0.42
16
163
8
51
1.59
0.61
1.9
2.1
—
—
—
0
0
10
64
1.59
0.59
1.1
1.2
—
—
—
0
0
10
64
1.59
0.59
1.1
1.2
—
—
—
0
0
6
37
1.64
0.56
1.5
1.3
—
—
—
0
0
100
911
1.17
0.55
5.7
4.7
0.0
0.0
estimate
0.50
21
170
6
38
1.59
0.54
2.5
1.4
—
—
—
0
0
16
117
1.39
0.54
1.1
1.3
—
—
—
0
0
180
1722
1.21
0.54
6.0
5.3
39.9
39.5
mmol/mol
0.22
163
1616
13
95
1.39
0.45
1.8
1.2
—
—
—
0
0
31
259
1.23
0.43
1.8
2.1
—
—
—
0
0
5
32
1.57
0.42
1.8
1.2
—
—
—
0
0
73
661
1.15
0.42
3.5
3.4
30.1
32.4
ng/l
0.09
52
422
0
16
0.00
0.41
0.0
1.6
—
—
—
0
0
0
17
0.00
0.41
0.0
1.6
—
5.6
—
0
7
0
18
0.00
0.40
0.0
1.3
—
—
—
0
0
5
37
1.36
0.37
2.2
1.3
—
—
—
0
0
15
190
0.77
0.37
1.4
1.8
—
—
—
0
0
6
41
1.48
0.36
2.5
1.4
—
—
—
0
0
6
47
1.28
0.32
1.0
1.2
—
51.0
—
0
5
6
47
1.28
0.32
1.2
2.6
28.0
29.6
mg/l
—
6
38
6
47
1.28
0.32
1.2
2.6
44.1
66.0
mg/l
—
6
39
188
1832
1.14
0.30
4.8
4.3
5.8
5.9
mmol/l
0.19
168
1690
8
109
0.72
0.29
1.6
1.9
—
—
—
0
0
8
64
1.26
0.28
1.1
1.8
—
—
—
0
0
24
207
1.18
0.26
2.8
3.0
0.9
0.7
ug/l
0.76
18
119
18
213
0.83
0.26
6.7
6.1
—
—
—
0
0
5
75
0.66
0.26
1.6
1.4
—
—
—
0
0
31
275
1.15
0.24
3.2
4.6
25.9
21.3
%
0.94
17
129
5
38
1.32
0.23
1.8
1.4
—
—
—
0
0
11
88
1.26
0.23
1.2
2.4
46.4
42.3
u/l
0.25
11
79
0
11
0.00
0.21
0.0
2.0
—
—
—
0
0
0
11
0.00
0.21
0.0
1.2
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
0
10
0.00
0.21
0.0
2.1
—
—
—
0
0
0
10
0.00
0.21
0.0
2.1
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
89.9
—
0
10
0
12
0.00
0.21
0.0
1.0
—
—
—
0
0
5
43
1.17
0.21
1.2
2.1
0.0
0.0
g/l
—
5
43
5
43
1.17
0.21
1.2
2.1
0.0
0.0
g/l
—
5
43
169
1653
1.08
0.18
22.6
15.1
13.5
13.6
%
0.31
169
1632
7
59
1.19
0.18
1.7
1.5
—
—
—
0
0
34
311
1.11
0.18
3.4
2.7
2.4
2.4
mmol/l
0.00
29
279
10
84
1.20
0.14
6.9
4.3
1.6
1.2
%
—
10
84
13
149
0.86
0.14
3.2
2.8
50.9
71.4
ml/min/173m2
—
8
58
182
1794
1.07
0.12
4.5
3.8
1.2
1.3
mmol/l
0.80
163
1663
5
46
1.09
0.09
1.2
2.1
0.0
0.0
g/l
—
5
46
43
411
1.06
0.08
1.5
1.5
—
—
—
0
0
6
73
0.82
0.07
1.5
1.7
—
—
—
0
0
70
716
0.97
0.05
4.3
3.6
—
—
—
0
0
192
1910
1.03
0.03
5.2
4.6
2.8
2.8
mmol/l
0.08
168
1770
188
1870
1.03
0.03
4.9
4.2
1.5
1.5
mmol/l
0.41
163
1732
189
1881
1.03
0.02
4.9
4.2
4.7
4.8
mmol/l
0.26
169
1751
14
138
1.02
0.00
1.8
1.9
—
—
—
0
0
49
489
1.00
0.00
5.0
3.7
0.0
0.0
estimate
0.50
19
172
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
0
7
0.00
0.00
0.0
1.4
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
5
49
1.02
0.00
1.4
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
9
98
0.92
0.00
3.0
8.3
1.1
1.5
%
—
9
98
0
6
0.00
0.00
0.0
1.5
—
—
—
0
0
7
79
0.88
0.00
1.3
1.4
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.6
—
—
—
0
0
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint L12_NAIL_LYSIS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_NAIL_LYSIS | 1.582 [1.07, 2.33] | 0.02 |
| Birth year | 0.995 [0.99, 1.0] | 0.282 |
During the follow-up period (1.1.1998 — 31.12.2019), 73 out of 827 females with L12_NAIL_LYSIS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_NAIL_LYSIS | 1.692 [1.09, 2.62] | 0.018 |
| Birth year | 0.985 [0.98, 0.99] | 0.003 |
During the follow-up period (1.1.1998 — 31.12.2019), 70 out of 543 males with L12_NAIL_LYSIS died.
Mortality risk
Mortality risk for people of age
years, who have L12_NAIL_LYSIS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.189% | 0.308% |
| 5 | 0.914% | 1.598% |
| 10 | 2.268% | 4.152% |
| 15 | 4.445% | 7.92% |
| 20 | 7.88% | 13.34% |
Relationships between endpoints
↥Index endpoint: L12_NAIL_LYSIS – Onycholysis
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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