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Other acquired deformities of ankle and foot

EFO MESH Endpoint Browser PheWeb

M13_ANKLEFOOT

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

519972

1. Apply sex-specific rule

None

519972

2. Check conditions

None

519972

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — M21.6
  • Hospital discharge: ICD-9 — 7367
  • Cause of death: ICD-10 — M21.6
  • Cause of death: ICD-9 — 7367

2 out of 7 registries used, show all original rules.

313

4. Check minimum number of events

None

313

5. Include endpoints

None

313

6. Filter based on genotype QC (FinnGen only)

306

Control definitions (FinnGen only)

Control exclude
M13_ARTHROPATHIES

Extra metadata

Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
M21
Name in latin
Aliae deformitates acquisitae tarsi et pedis

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 2070 1328 732
Only index persons 1951 1272 679
Unadjusted period prevalence (%)
Whole population 0.03 0.04 0.02
Only index persons 0.04 0.05 0.03
Median age at first event (years)
Whole population 49.53 52.51 44.04
Only index persons 49.39 52.17 44.18

-FinnGen-

Key figures

All Female Male
Number of individuals 306 215 91
Unadjusted period prevalence (%) 0.07 0.08 0.04
Median age at first event (years) 52.54 52.42 52.80

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
313
Matched controls
3130
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
M21.6
ICD-10 Finland
Other acquired deformities of ankle and foot
8383.8
307.7
263
*
M19.0
ICD-10 Finland
Primary arthrosis of other joints
52.7
143.2
85
22
M17.1
ICD-10 Finland
Other primary gonarthrosis
31.0
135.5
96
44
NH3AA
NOMESCO Finland
Foot and toes X-ray examination
21.8
96.8
78
47
M20.1
ICD-10 Finland
Hallux valgus (acquired)
32.8
88.3
59
22
M17.0
ICD-10 Finland
Primary gonarthrosis, bilateral
22.5
79.8
62
34
NG1AA
NOMESCO Finland
Knee X-ray examination without contrast
14.9
66.3
64
53
7367A
ICD-9 Finland
Other acquired deformities of limbs, Other acquired deformities of ankle and foot
+∞
53.7
50
*
NHU20
NOMESCO Finland
Removal of internal fixation device from ankle or foot
19.0
52.3
43
26
NGB20
NOMESCO Finland
Primary total prosthetic replacement of knee joint without patellar part
+∞
51.5
48
*
M20.4
ICD-10 Finland
Other hammer toe(s) (acquired)
96.6
45.3
49
6
M25.5
ICD-10 Finland
Pain in joint
5.3
44.3
130
372
NHK30
NOMESCO Finland
Osteotomy or rotation osteotomy of first metatarsal or tarsal bone
+∞
40.5
38
*
N03AX12
ATC
[U] gabapentin; oral
5.8
39.7
89
200
NJ2MA
NOMESCO Finland
Measurement of mechanical axis of lower leg with X-ray
+∞
39.4
37
*
NHK40
NOMESCO Finland
Osteotomy or rotation osteotomy of II-V metatarsal or tarsal bone
426.9
38.9
38
*
WX320
NOMESCO Finland
Spinalanesthesy
5.1
37.0
101
268
NHG80
NOMESCO Finland
Fusion of first tarsometatarsal joint
+∞
36.1
34
*
N02AX02
ATC
tramadol; systemic, rectal
4.3
35.7
173
705
NHK99
NOMESCO Finland
Other operation on bone of ankle or foot
107.8
35.6
38
*
M23.2
ICD-10 Finland
Derangement of meniscus due to old tear or injury
107.8
35.6
38
*
M21.4
ICD-10 Finland
Flat foot [pes planus] (acquired)
46.8
34.0
41
10
M01AX05
ATC
glucosamine; oral
5.2
32.2
80
194
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
3.9
31.7
173
750
NGD05
NOMESCO Finland
Partial excision of meniscus of knee, arthroscopic
11.1
31.5
35
35
L16
ICPC
Ankle symptom/complaint
5.4
29.7
67
149
M77.4
ICD-10 Finland
Metatarsalgia
7.3
29.0
46
72
N03AX16
ATC
[U] pregabalin
4.1
28.8
104
336
NGF25
NOMESCO Finland
Operation for osteochondritis of knee, arthroscopic
37.9
27.1
34
10
L17
ICPC
Foot/toe symptom/complaint
3.7
27.0
128
495
M17.9
ICD-10 Finland
Gonarthrosis, unspecified
6.7
26.9
46
78
M19.1
ICD-10 Finland
Post-traumatic arthrosis of other joints
282.7
26.1
26
*
M01AH05
ATC
etoricoxib; oral
3.6
24.9
220
1235
NH1AA
NOMESCO Finland
Ankle X-ray examination without contrast
6.3
24.8
45
81
NHL68
NOMESCO Finland
Tenodesis, shortening or lengthening of tendon of foot
+∞
24.3
23
*
NHG77
NOMESCO Finland
Arthroplasty of interphalangeal tarsal joint(s)
+∞
24.3
23
*
QDB10
NOMESCO Finland
Major dressing of wound of skin of lower limb
7.6
23.4
35
51
M79.6
ICD-10 Finland
Pain in limb
3.2
23.3
162
778
L15
ICPC
Knee symptom/complaint
3.8
23.0
91
308
B01AB05
ATC
enoxaparin; parenteral
3.4
22.2
115
461
SPAT1229
SPAT
Assessment of need for aid
5.9
21.7
42
80
TNX50
NOMESCO Finland
Removal of cutom molded cast and internal stretch
7.0
20.1
32
50
9271
FHL
Hallux surgery
+∞
20.0
19
*
P01BA02
ATC
hydroxychloroquine; oral
9.0
19.5
25
30
N02AJ06
ATC
codeine and paracetamol; systemic
2.9
19.4
150
746
L28
ICPC
Limited function/disability (L)
3.7
19.2
74
244
L04AX03
ATC
methotrexate; systemic
7.6
19.0
28
40
M20.2
ICD-10 Finland
Hallux rigidus
74.6
18.9
21
*
B01AF01
ATC
rivaroxaban; oral
4.6
18.8
49
121
NGA30
NOMESCO Finland
Exploration of knee joint, arthroscopic
27.0
18.5
25
10
NHK10
NOMESCO Finland
Incision or excision of metatarsal or tarsal bone
47.1
18.5
22
5
SPAT1223
SPAT
Implementation of physical therapy rehabilitation plan
3.1
18.4
107
453
M01AH01
ATC
celecoxib; oral
3.7
17.7
67
217
Z03.9
ICD-10 Finland
Observation for suspected disease or condition, unspecified
3.3
17.5
79
287
M16.1
ICD-10 Finland
Other primary coxarthrosis
13.8
17.0
29
23
M22.4
ICD-10 Finland
Chondromalacia patellae
67.2
16.9
19
*
M09AX01
ATC
hyaluronic acid; parenteral
17.6
16.9
26
16
NHG24
NOMESCO Finland
Fusion of subtalar joint and between bones of ankle
+∞
16.8
16
*
N02BF01
ATC
gabapentin; oral
5.0
16.6
38
84
ZY020
NOMESCO Finland
Telephone, letter or other consultation without direct patient contact
5.1
16.1
36
78
ZXA05
NOMESCO Finland
Left side
3.0
16.0
91
376
NH3FA
NOMESCO Finland
Weight-bearing X-ray of foot
63.4
15.9
18
*
M19.2
ICD-10 Finland
Other secondary arthrosis
+∞
15.8
15
*
NHG76
NOMESCO Finland
Arthroplasty of other tarsometatarsal joint
+∞
15.8
15
*
NHG26
NOMESCO Finland
Fusion between bones of ankle or ankle and foot
168.1
15.6
16
*
TNX92
NOMESCO Finland
Supporting bandage or orthosis of lower limb
19.6
14.9
22
12
TNX10
NOMESCO Finland
Arthrocentesis, unspecified region, unspecified region
15.2
14.8
24
17
S18
ICPC
Laceration/cut
2.5
14.7
153
854
NHG82
NOMESCO Finland
Fusion of other tarsal joint
+∞
14.7
14
*
NHG22
NOMESCO Finland
Fusion of subtalar joint
+∞
14.7
14
*
M05.8
ICD-10 Finland
Other seropositive rheumatoid arthritis
157.0
14.6
15
*
9273
FHL
Other surgery for toe deformity or pain condition, e.g., Morton, hammer toe
157.0
14.6
15
*
M20.5
ICD-10 Finland
Other deformities of toe(s) (acquired)
157.0
14.6
15
*
M13.9
ICD-10 Finland
Arthritis, unspecified
12.2
14.6
26
23
J01FF01
ATC
clindamycin; systemic
2.7
14.4
106
500
A07EC01
ATC
sulfasalazine; oral, rectal
6.8
14.3
23
36
NH1AD
NOMESCO Finland
Ankle and foot CT
21.3
14.0
20
10
NH1BG
NOMESCO Finland
Ankle and foot MRI examination with high intensity magnet
25.2
14.0
19
8
SPAT1230
SPAT
Aid fitting and borrowing and monitoring of use
3.3
13.9
62
221
M17
ICD-10 Finland
Gonarthrosis [arthrosis of knee]
4.5
13.9
36
88
TNX33
NOMESCO Finland
Custom moulded cast, unspecified region
5.2
13.9
30
63
NA3BG
NOMESCO Finland
Lumbar spine MRI examination with high intensity magnet
4.2
13.6
39
103
M48.0
ICD-10 Finland
Spinal stenosis
3.8
13.6
45
132
NHL14
NOMESCO Finland
Shortening or lengthening of achilles tendon
146.1
13.6
14
*
NGF35
NOMESCO Finland
Plastic operation of joint cartilage of knee
146.1
13.6
14
*
M01AX17
ATC
nimesulide; oral
2.8
13.3
86
377
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
3.6
13.3
49
155
L90
ICPC
Osteoarthrosis of knee
10.0
13.3
26
28
Y83
ICD-10 Finland
Surgical operation and other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
4.4
13.2
35
87
M01AH02
ATC
rofecoxib; oral
3.7
13.0
45
136
NG2AA
NOMESCO Finland
Patella X-ray examination
52.3
13.0
15
*
M01AB55
ATC
diclofenac, combinations; oral
4.8
12.7
30
68
7350A
ICD-9 Finland
Acquired deformities of toe, Hallux valgus (acquired)
+∞
12.6
12
*
NHG20
NOMESCO Finland
Fusion of talocrural joint
+∞
12.6
12
*
R06.0
ICD-10 Finland
Dyspnoea
2.6
12.3
94
446
M16.0
ICD-10 Finland
Primary coxarthrosis, bilateral
13.1
12.3
21
17
M15.9
ICD-10 Finland
Polyarthrosis, unspecified
5.8
12.3
23
42
M01AE02
ATC
naproxen; oral, rectal
2.4
12.2
192
1255
9102
FHL
Trepanation or removal of the local bone process
28.0
12.2
16
6
NK4XE
NOMESCO Finland
Joint ultrasound examination not elsewhere classified
14.2
12.1
20
15
WX002
NOMESCO Finland
Sedation and analgesia
2.9
11.8
66
267
H02AB06
ATC
prednisolone; systemic
2.3
11.8
149
884
NFB30
NOMESCO Finland
Primary total prosthetic replacement of hip joint not using cement
31.4
11.7
15
5
TQW40
NOMESCO Finland
Remowal of suture of skin
4.4
11.7
31
77
M51.3
ICD-10 Finland
Other specified intervertebral disc degeneration
5.0
11.6
26
56
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
4.4
11.6
30
73
7177A
ICD-9 Finland
Internal derangement of knee, Chondromalacia of patella
+∞
11.5
11
*
9351
FHL
Metatarsus osteotomies
+∞
11.5
11
*
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
4.6
11.5
28
65
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
2.3
11.2
138
805
M54.5
ICD-10 Finland
Low back pain
2.3
11.2
121
669
M01AH03
ATC
valdecoxib; oral
4.5
11.1
28
67
NH1CG
NOMESCO Finland
Ankle and foot extensive MRI examination with high intensity magnet
45.0
11.0
13
*
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
2.4
10.9
106
559
G56.0
ICD-10 Finland
Carpal tunnel syndrome
3.1
10.8
50
181
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
3.3
10.8
44
148
NH3EA
NOMESCO Finland
Feet X-ray examination with load
62.2
10.7
12
*
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
3.7
10.5
35
103
ZXA00
NOMESCO Finland
Right side
2.5
10.5
85
412
M06.0
ICD-10 Finland
Seronegative rheumatoid arthritis
+∞
10.5
10
*
M70.6
ICD-10 Finland
Trochanteric bursitis
3.0
10.4
50
185
A02BC05
ATC
esomeprazole; systemic
2.2
10.3
133
786
N02BE01
ATC
paracetamol; systemic, rectal
3.7
10.3
287
2349
ACC59
NOMESCO Finland
Decompression and freeing of adhesions of peripheral nerve: other or unspecified
5.3
10.2
21
42
NG1BG
NOMESCO Finland
Knee and lower leg MRI examination with high intensity magnet
15.2
10.1
16
11
Z96.6
ICD-10 Finland
Presence of orthopaedic joint implants
41.5
10.0
12
*
J01MA12
ATC
levofloxacin; systemic
2.6
10.0
66
289
L08
ICPC
Shoulder symptom/complaint
2.5
10.0
72
329
NH3BA
NOMESCO Finland
Foot and toes extensive X-ray examination
12.8
10.0
17
14
T81.4
ICD-10 Finland
Infection following a procedure, not elsewhere classified
3.2
9.9
42
144
J01DB01
ATC
cefalexin; oral
2.7
9.9
264
2077
M02AA10
ATC
ketoprofen; topical
2.8
9.9
58
239
M02AA07
ATC
piroxicam; topical
2.2
9.8
117
667
R5110, ,
SPAT
4.3
9.7
26
65
M17.3
ICD-10 Finland
Other post-traumatic gonarthrosis
56.8
9.7
11
*
G57.6
ICD-10 Finland
Lesion of plantar nerve
11.9
9.7
17
15
SPAT1153
SPAT
Removal of sutures
2.3
9.7
97
514
R60.0
ICD-10 Finland
Localized oedema
3.0
9.5
45
165
R52.9
ICD-10 Finland
Pain, unspecified
3.2
9.5
40
137
Z01.8
ICD-10 Finland
Other specified special examinations
2.4
9.5
77
372
NH3DA
NOMESCO Finland
Bilateral foot X-ray examination
103.0
9.5
10
*
NHL30
NOMESCO Finland
Suture or reinsertion of tendon of foot
22.5
9.4
13
6
73799
ICD-8 Finland
Hallux valgus and varus
+∞
9.4
9
*
M21.5
ICD-10 Finland
Acquired clawhand, clubhand, clawfoot and clubfoot
+∞
9.4
9
*
B01AX06
ATC
[U] rivaroxaban
+∞
9.4
9
*
ACC51
NOMESCO Finland
Release of median nerve
3.9
9.4
28
76
M19.9
ICD-10 Finland
Arthrosis, unspecified
8.4
9.0
19
24
Z00.0
ICD-10 Finland
General medical examination
2.4
8.9
73
353
A02BC02
ATC
pantoprazole; systemic
2.1
8.9
208
1511
N06AA09
ATC
amitriptyline; systemic
3.3
8.8
34
110
N02BF02
ATC
pregabalin; oral
4.5
8.8
22
52
Q66.7
ICD-10 Finland
Pes cavus
51.5
8.7
10
*
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.2
8.7
92
496
M01AE03
ATC
ketoprofen; systemic, rectal
2.1
8.5
114
672
RD211, ,
NOMESCO Finland
4.2
8.5
23
58
L04AA13
ATC
[U] leflunomide
92.4
8.5
9
*
N02AA05
ATC
oxycodone; systemic
2.6
8.5
56
245
NHK68
NOMESCO Finland
Shortening or lengthening osteotomy of ankle or foot
+∞
8.4
8
*
7151F
ICD-9 Finland
Osteo-arthrosis and allied disorders, Osteo-arthrosis, localised, primary[OSTEOARTHROSIS PRIMARIA, POLVI]
+∞
8.4
8
*
NGE10
NOMESCO Finland
Incision or suture of capsule of knee joint
+∞
8.4
8
*
NHG70
NOMESCO Finland
Arthroplasty of first tarsometatarsal joint
+∞
8.4
8
*
WX111
NOMESCO Finland
Local infiltration anesthesia
+∞
8.4
8
*
J01DA01
ATC
[U] cefalexin
2.0
8.3
199
1443
J01MA02
ATC
ciprofloxacin; systemic
2.0
8.2
121
738
M01AB05
ATC
diclofenac; systemic, rectal
2.0
8.2
200
1456
M01AC06
ATC
meloxicam; systemic, rectal
2.1
8.1
109
642
NH1FA
NOMESCO Finland
Weight-bearing X-ray of ankle
22.7
8.1
11
5
R03DC03
ATC
montelukast; oral
2.4
8.0
60
278
S20
ICPC
Corn/callosity
13.5
7.9
13
10
L03
ICPC
Low back symptom/complaint
2.1
7.9
89
489
X58
ICD-10 Finland
Exposure to other specified factors
2.6
7.9
49
207
NF1AA
NOMESCO Finland
Hip X-ray examination
3.7
7.9
25
71
1220
FHL
Arthroscopy
9.8
7.9
15
16
SPAT1144
SPAT
Treatment of reopened or infected surgical wound
3.5
7.9
28
86
L84
ICD-10 Finland
Corns and callosities
6.7
7.8
19
30
L13
ICPC
Hip symptom/complaint
2.5
7.8
55
248
NF1DA
NOMESCO Finland
X-ray of hips
46.1
7.8
9
*
M01AB01
ATC
indometacin; systemic, rectal
3.7
7.7
25
72
M75.1
ICD-10 Finland
Rotator cuff syndrome
2.2
7.7
72
367
WZA90
NOMESCO Finland
Other medical or dental certificate
2.2
7.7
80
426
TNX39
NOMESCO Finland
Other orthopedic bandage, unspecified region
12.3
7.6
13
11
M54.4
ICD-10 Finland
Lumbago with sciatica
2.4
7.6
56
257
R03AC02
ATC
salbutamol; inhalant
1.9
7.6
176
1246
ZZH21
NOMESCO Finland
Graft of patients own bone, small pieces
11.2
7.4
13
12
SPAT1202
SPAT
Intra-articular injection
11.2
7.4
13
12
TNG10
NOMESCO Finland
Puncture of knee
+∞
7.3
7
*
R01AD58
ATC
fluticasone, combinations; nasal
2.1
7.3
82
449
NHQ40
NOMESCO Finland
Amputation of toe
16.2
7.3
11
7
M15
ICD-10 Finland
Polyarthrosis
4.7
7.3
17
38
A28
ICPC
Limited function/disability NOS
2.4
7.2
52
236
R01AD12
ATC
fluticasone furoate; nasal
2.0
7.2
102
608
L97
ICD-10 Finland
Ulcer of lower limb, not elsewhere classified
5.9
7.2
19
34
L01BA01
ATC
methotrexate; systemic
30.8
7.2
9
*
ACC19
NOMESCO Finland
Transcision of peripheral nerve: other or unspecified
20.6
7.2
10
5
SPAT1220
SPAT
Assessment of need for rehabilitation and/or rehabilitation plan
3.8
7.2
22
61
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
2.6
7.1
42
173
R4110, ,
SPAT
2.9
7.1
35
131
N06AX21
ATC
duloxetine; oral
2.7
7.1
39
155
SPAT1148
SPAT
Treatment of chronic ulcer or burn
2.6
7.1
43
180
SPAT1149
SPAT
Suture or treatment of traumatic wound
2.7
7.0
41
168
ND2AA
NOMESCO Finland
Hand and fingers X-ray examination
3.4
7.0
25
77
XA402
NOMESCO Finland
ENMG
8.6
6.9
14
17
J45.9
ICD-10 Finland
Asthma, unspecified
2.2
6.8
62
311
1221
FHL
Arthroscopy and meniscus surgery
41.0
6.8
8
*
G57.8
ICD-10 Finland
Other mononeuropathies of lower limb
41.0
6.8
8
*
1223
FHL
Arthroscopy and articular cartilage surgery
41.0
6.8
8
*
I10
ICD-10 Finland
Essential (primary) hypertension
1.9
6.8
180
1314
E0000UV, ,
ATC
1.9
6.7
130
857
R06AE07
ATC
cetirizine; oral
1.9
6.7
142
963
M19.8
ICD-10 Finland
Other specified arthrosis
6.7
6.7
16
25
S83.6
ICD-10 Finland
Sprain and strain of other and unspecified parts of knee
4.2
6.7
18
45
J32.0
ICD-10 Finland
Chronic maxillary sinusitis
3.1
6.7
29
101
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.9
6.6
134
895
NBG15
NOMESCO Finland
Acromioplastia, arthroscopic
4.3
6.6
17
41
L86
ICPC
Back syndrome with radiating pain
3.5
6.6
23
70
M03BX02
ATC
tizanidine; oral
1.9
6.5
188
1400
L01
ICPC
Neck symptom/complaint
2.3
6.5
51
241
NDG76
NOMESCO Finland
Fusion of DIP joint
71.2
6.4
7
*
S93.4
ICD-10 Finland
Sprain and strain of ankle
2.6
6.4
40
169
L14
ICPC
Leg/thigh symptom/complaint
2.8
6.4
32
121
Z01.2
ICD-10 Finland
Dental examination
1.8
6.3
141
967
SPAT1216
SPAT
Assessment of functional ability
2.3
6.3
51
244
NDG60
NOMESCO Finland
Arthroplasty of first CMC joint
+∞
6.3
6
*
M17.5
ICD-10 Finland
Other secondary gonarthrosis
+∞
6.3
6
*
NHL20
NOMESCO Finland
Myotomy or tenotomy of foot
+∞
6.3
6
*
WX214
NOMESCO Finland
Plexus blockade at the ankle
+∞
6.3
6
*
NGK30
NOMESCO Finland
Angulation, rotation or displacement osteotomy of knee or lower leg
+∞
6.3
6
*
M67.0
ICD-10 Finland
Short Achilles tendon (acquired)
27.3
6.3
8
*
NHL99
NOMESCO Finland
Other operation on muscle or tendon of ankle or foot
27.3
6.3
8
*
SPAT1263
SPAT
Sampling
1.8
6.2
132
892
W17
ICD-10 Finland
Other fall from one level to another
4.3
6.2
16
39
T84.0
ICD-10 Finland
Mechanical complication of internal joint prosthesis
12.9
6.1
10
8
TNX34
NOMESCO Finland
Major custom molded cast, unspecified region
8.9
6.1
12
14
SPAT1211
SPAT
Application of soft bandage
2.8
6.1
31
118
A46
ICD-10 Finland
Erysipelas
2.5
6.1
41
180
R42
ICD-10 Finland
Dizziness and giddiness
2.0
6.1
72
400
NDU20
NOMESCO Finland
Removal of internal fixation device from wrist or hand
10.3
6.1
11
11
J01FA10
ATC
azithromycin; systemic
1.8
6.1
183
1370
Z04.8
ICD-10 Finland
Examination and observation for other specified reasons
2.3
6.0
47
221
TNX32
NOMESCO Finland
Custom moulded splint, unspecified region
3.8
6.0
18
49
N04BC05
ATC
pramipexole; oral
3.0
6.0
27
96

LabWAS

↥
OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
79
292
3.28
16.95
1.2
1.1
73.54
1.37
u/ml
0.67
28
108
103
501
2.57
12.92
2.1
2.3
333.75
10065.83
umol/l
3.55
87
444
76
321
2.81
12.59
1.3
1.2
24.34
14.61
iu/ml
0.65
18
95
239
1725
2.63
12.16
4.9
3.2
11.90
11.31
mm/h
0.25
220
1567
142
850
2.23
10.73
3.6
3.3
30.90
42.60
ng/l
0.49
95
579
98
543
2.17
8.64
2.3
2.0
2.83
2.89
mg/l
0.11
80
444
159
1059
2.02
8.50
6.1
5.7
—
—
—
0
0
66
312
2.41
8.45
1.3
1.2
—
—
—
0
0
155
1026
2.01
8.40
11.6
11.4
1.21
1.19
inr
0.08
42
316
55
247
2.49
7.84
1.4
1.3
1080.00
454.07
titre
0.55
12
54
54
241
2.50
7.80
1.8
1.7
—
—
—
0
0
60
283
2.39
7.68
2.2
1.8
—
—
—
0
0
169
1177
1.95
7.68
6.1
5.5
0.18
0.18
e9/l
0.01
155
1018
99
575
2.06
7.57
3.7
3.8
—
—
—
0
0
163
1128
1.93
7.49
5.9
5.0
0.04
0.04
e9/l
0.47
150
961
49
218
2.48
7.10
3.4
4.1
—
—
—
0
0
165
1164
1.88
6.98
5.9
5.0
1.79
1.96
e9/l
0.75
152
1022
161
1127
1.88
6.98
5.9
5.0
0.58
0.56
e9/l
0.41
149
963
10
6
17.16
6.79
1.7
1.0
—
—
—
0
0
163
1153
1.86
6.77
7.6
6.4
1.22
1.22
mmol/l
0.04
147
980
289
2510
2.97
6.64
16.2
11.9
22.73
24.22
mg/l
0.30
252
1872
213
1646
1.92
6.64
5.3
3.8
—
—
—
0
0
136
922
1.84
6.36
1.9
1.9
107.55
97.01
pmol/l
1.22
70
460
183
1367
1.82
6.14
4.1
4.5
6.60
6.69
mmol/l
0.23
174
1272
11
11
10.31
6.08
1.1
1.0
—
—
—
0
0
149
1058
1.78
5.84
5.2
5.5
1.22
1.22
mmol/l
0.02
137
962
147
1056
1.74
5.41
2.5
2.4
—
—
—
0
0
153
1117
1.72
5.27
6.7
5.1
27.52
27.79
%
0.11
148
1049
56
298
2.07
5.27
2.5
2.3
2.29
2.38
g/l
0.53
50
279
58
320
2.00
4.94
2.6
2.4
12.34
14.04
umol/l
1.00
52
298
290
2599
2.58
4.83
17.8
13.7
139.51
139.66
mmol/l
0.47
284
2514
227
1874
1.77
4.80
7.6
7.1
76.43
77.24
u/l
0.14
218
1755
290
2606
2.54
4.68
17.9
13.9
3.98
3.95
mmol/l
0.76
283
2515
107
728
1.71
4.63
2.6
2.4
55.85
64.86
u/l
0.59
100
672
237
1992
1.78
4.58
4.8
3.8
14.91
14.81
pmol/l
0.23
219
1807
177
1380
1.65
4.50
8.5
9.2
4.22
4.12
e9/l
0.19
162
1188
142
1052
1.64
4.39
2.7
2.6
99.70
113.85
ug/l
0.62
129
967
268
2352
1.97
4.34
5.6
4.6
1.73
2.43
mu/l
0.75
248
2139
96
651
1.68
4.14
4.3
3.4
—
—
—
0
0
31
144
2.28
4.09
4.9
2.5
—
—
—
0
0
263
2316
1.85
3.90
6.5
5.2
40.52
39.49
mmol/mol
0.79
248
2122
15
49
3.16
3.86
2.5
3.1
24.08
25.05
mmol/l
0.37
15
49
81
536
1.69
3.79
1.6
1.5
20.40
21.34
nmol/l
0.21
71
449
108
773
1.61
3.71
3.9
2.8
—
—
—
0
0
48
274
1.89
3.69
2.3
2.4
20.30
23.60
%
1.03
39
242
35
179
2.08
3.66
3.1
2.9
67.75
72.93
e9/l
0.45
28
129
150
1167
1.55
3.55
4.4
3.4
0.00
0.01
estimate
0.50
31
204
305
2891
3.15
3.49
24.2
17.5
6.66
6.58
e9/l
0.35
300
2798
100
713
1.59
3.45
2.0
2.2
—
—
—
0
0
29
142
2.15
3.39
1.3
2.7
—
—
—
0
0
14
48
3.01
3.34
3.8
2.1
—
—
—
0
0
62
399
1.69
3.19
1.8
1.6
1291.34
1264.11
nmol/l
0.07
44
295
129
993
1.51
3.10
4.7
4.7
35.17
36.05
g/l
1.09
122
934
304
2889
2.82
3.08
24.1
17.6
40.09
40.12
%
0.03
285
2716
199
1679
1.51
3.02
3.1
2.9
50.54
42.47
u/l
0.36
188
1567
83
583
1.58
3.01
1.4
1.3
2.68
1.69
u/ml
0.21
26
147
148
1182
1.48
2.92
4.3
3.4
0.00
0.02
estimate
0.50
30
198
74
514
1.58
2.80
1.6
1.6
1.10
1.02
mg/l
0.08
50
379
9
23
4.00
2.79
1.1
1.4
—
—
—
0
0
89
646
1.53
2.77
3.1
3.1
860.38
254.40
mg/l
0.33
62
403
11
34
3.31
2.75
2.7
3.3
—
—
—
0
0
288
2675
1.96
2.72
16.0
11.1
—
—
—
0
0
32
178
1.89
2.68
3.7
3.4
—
—
—
0
0
68
468
1.58
2.67
1.8
1.7
453.75
15113795.23
pmol/l
0.50
57
397
40
240
1.76
2.64
3.0
2.8
1.63
1.80
%
0.77
35
220
21
101
2.16
2.59
3.4
3.2
—
—
—
0
0
95
712
1.48
2.51
3.0
3.0
7.06
7.41
mmol/l
0.26
84
612
43
268
1.70
2.49
1.4
1.4
—
—
—
0
0
144
1171
1.43
2.46
5.6
4.7
0.00
0.01
estimate
0.50
32
197
11
38
2.96
2.44
2.4
2.4
—
—
—
0
0
31
178
1.82
2.37
1.3
1.4
—
—
—
0
0
90
680
1.45
2.26
3.6
3.7
9.25
8.60
mg/mmol
0.05
59
423
13
54
2.47
2.23
2.8
3.4
8.29
8.08
kpa
0.18
13
54
275
2550
1.65
2.20
4.8
4.0
4.73
4.79
mmol/l
0.43
258
2360
9
30
3.06
2.16
5.2
1.7
—
—
—
0
0
81
608
1.45
2.09
4.9
3.7
0.00
0.01
estimate
0.50
31
194
269
2489
1.57
2.08
4.8
4.1
5.97
5.88
mmol/l
0.41
246
2258
291
2748
1.84
2.06
11.7
9.0
25.52
25.74
u/l
0.08
280
2638
18
90
2.06
2.05
3.4
1.7
—
—
—
0
0
14
63
2.28
2.04
1.0
1.1
—
—
—
0
0
264
2441
1.52
1.96
4.3
3.6
1.31
1.26
mmol/l
0.42
246
2237
64
466
1.47
1.93
2.7
2.4
6.49
7.90
e6/l
0.26
57
420
25
144
1.80
1.91
3.6
4.3
—
—
—
0
0
277
2593
1.59
1.88
5.2
4.5
2.76
2.86
mmol/l
1.07
260
2388
103
831
1.36
1.72
3.1
3.9
2.37
2.37
mmol/l
0.08
89
744
39
263
1.55
1.69
1.3
1.3
—
—
—
0
0
6
19
3.20
1.67
1.8
2.3
1.15
1.87
g/24h
—
6
12
37
248
1.56
1.64
1.8
1.6
—
—
—
0
0
270
2531
1.49
1.63
4.9
4.0
1.53
1.51
mmol/l
0.22
252
2327
5
14
3.61
1.62
17.4
8.9
0.60
0.66
mmol/l
—
5
14
123
1028
1.32
1.61
2.0
2.0
—
—
—
0
0
8
33
2.46
1.55
2.6
3.1
—
—
—
0
0
5
15
3.37
1.53
2.2
1.3
75.40
72.00
umol/l
—
5
15
68
523
1.38
1.52
5.4
3.6
1.02
1.02
kg/l
0.21
15
68
194
1739
1.30
1.47
4.1
3.5
—
—
—
0
0
5
16
3.16
1.44
1.8
1.9
727.60
653.94
e6/l
—
5
16
9
39
2.35
1.44
1.2
1.2
—
—
—
0
0
26
168
1.60
1.36
4.9
4.5
0.20
0.77
%
—
5
61
28
185
1.56
1.34
5.4
4.5
0.86
1.22
%
—
7
73
113
953
1.29
1.34
3.9
3.2
5.88
5.81
ph
—
8
80
36
252
1.48
1.34
1.7
1.6
—
—
—
0
0
99
823
1.30
1.31
4.0
3.3
58.50
123.58
e6/l
0.82
70
555
26
171
1.57
1.28
5.7
4.7
0.00
0.17
%
—
5
60
81
657
1.31
1.28
3.5
3.0
—
—
—
0
0
8
35
2.32
1.28
2.7
3.0
5.22
5.21
kpa
—
8
35
8
35
2.32
1.28
2.7
3.0
8.54
8.74
kpa
—
8
35
36
255
1.47
1.27
1.3
1.4
—
—
—
0
0
28
190
1.52
1.21
2.7
2.5
8.41
7.18
ug/l
0.16
23
169
0
34
0.00
1.16
0.0
3.8
—
3.28
—
0
34
62
491
1.33
1.16
1.6
1.4
3.00
2.24
g/l
0.76
38
305
5
20
2.52
1.15
1.0
1.5
11.80
10.63
umol/l
—
5
20
15
88
1.74
1.13
3.5
4.0
—
—
—
0
0
10
51
1.99
1.12
1.0
1.2
—
—
—
0
0
85
706
1.28
1.12
4.8
3.8
7.40
7.40
ph
0.16
17
133
67
540
1.31
1.11
5.0
3.5
—
—
—
0
0
5
21
2.40
1.09
5.8
2.4
—
—
—
0
0
85
710
1.27
1.07
3.6
2.8
64.02
48.63
e6/l
0.20
68
519
14
82
1.74
1.07
6.3
4.9
1.58
1.57
%
0.01
14
74
9
47
1.94
1.03
2.6
2.9
7.43
7.42
ph
—
9
39
74
611
1.28
1.02
7.3
6.9
—
—
—
0
0
5
23
2.19
0.98
1.0
1.0
—
—
—
0
0
6
28
2.16
0.92
1.2
1.8
33.17
31.39
pg
—
6
28
13
80
1.65
0.86
6.2
5.0
0.89
0.93
%
0.08
13
73
11
175
0.62
0.81
1.4
1.5
—
—
—
0
0
121
1080
1.20
0.80
10.6
8.0
0.00
0.00
e9/l
0.71
102
868
22
157
1.43
0.79
1.5
1.6
—
—
—
0
0
28
209
1.37
0.79
1.1
1.1
—
—
—
0
0
11
67
1.67
0.76
2.5
2.5
—
—
—
0
0
7
40
1.77
0.71
1.3
1.1
—
—
—
0
0
20
145
1.41
0.67
3.0
2.5
3.69
9.49
e9/l
0.84
15
125
31
242
1.31
0.67
4.1
7.3
1.31
1.29
mmol/l
0.01
22
197
17
120
1.44
0.66
3.1
6.0
25.91
25.48
mmol/l
0.22
17
120
10
62
1.63
0.66
1.4
1.0
—
—
—
0
0
10
63
1.61
0.62
1.8
2.1
—
—
—
0
0
0
21
0.00
0.60
0.0
1.1
—
—
—
0
0
8
53
1.52
0.59
2.9
6.7
12.63
10.66
mmol/l
—
8
47
8
53
1.52
0.59
2.9
6.7
104.63
105.57
mmol/l
—
8
47
52
442
1.21
0.58
3.1
4.0
123.72
317.98
ng/l
0.81
43
333
8
54
1.49
0.57
1.1
1.9
5.99
4.91
mmol/24h
—
8
47
6
36
1.68
0.57
1.0
1.0
—
—
—
0
0
6
99
0.60
0.52
1.7
1.9
22.33
21.38
s
—
6
91
41
346
1.21
0.50
1.9
1.6
—
—
—
0
0
22
277
0.78
0.49
3.7
4.4
4.09
36.00
ug/l
0.73
16
234
231
2222
1.15
0.49
17.6
14.6
15.28
14.65
%
0.83
231
2182
62
701
0.86
0.49
1.4
1.4
—
—
—
0
0
55
479
1.18
0.48
5.2
4.2
2.52
2.91
ug/l
0.17
50
436
44
377
1.19
0.46
2.0
1.8
29.38
29.52
s
0.06
44
367
21
165
1.29
0.46
1.5
1.2
—
—
—
0
0
24
293
0.80
0.42
1.3
1.4
—
—
—
0
0
0
15
0.00
0.41
0.0
1.3
—
2.14
—
0
15
0
17
0.00
0.41
0.0
3.2
—
—
—
0
0
0
18
0.00
0.40
0.0
2.4
—
—
—
0
0
5
36
1.40
0.38
1.0
1.2
23.64
14.63
u/l
—
5
29
19
234
0.80
0.37
2.1
1.6
—
—
—
0
0
70
636
1.13
0.36
3.6
2.8
0.37
0.54
e6/l
0.37
57
460
5
77
0.64
0.36
1.0
1.1
—
—
—
0
0
23
190
1.23
0.36
1.2
1.2
18.50
154.45
iu/ml
6.45
14
71
6
44
1.37
0.34
1.0
1.3
—
—
—
0
0
6
44
1.37
0.34
1.5
2.3
—
—
—
0
0
15
118
1.28
0.34
3.7
3.3
—
—
—
0
0
10
132
0.75
0.33
5.7
8.6
0.69
0.68
%
—
10
132
17
137
1.25
0.32
3.5
3.0
129.71
127.46
g/l
0.22
17
132
10
131
0.76
0.31
5.7
8.6
1.53
1.52
%
—
10
131
7
96
0.72
0.31
1.0
1.3
—
—
—
0
0
19
158
1.22
0.29
1.3
1.6
—
—
—
0
0
51
463
1.12
0.28
2.5
2.6
451.13
524.67
mosm/kgh2o
1.51
40
396
9
72
1.26
0.26
4.1
3.0
3.82
3.89
mmol/l
—
9
72
16
133
1.21
0.24
1.1
1.2
—
—
—
0
0
16
134
1.20
0.23
1.1
1.1
—
5.20
titre
—
0
5
5
39
1.29
0.23
1.0
1.0
—
—
—
0
0
24
273
0.87
0.22
5.8
5.4
102.88
103.88
mmol/l
0.36
24
273
22
191
1.16
0.22
3.1
7.5
—
—
—
0
0
57
614
0.91
0.22
3.9
3.4
89.40
93.20
%
0.58
57
602
5
41
1.22
0.22
2.0
2.3
72.60
65.10
%
—
5
41
0
11
0.00
0.21
0.0
1.6
—
—
—
0
0
0
11
0.00
0.21
0.0
1.3
—
—
—
0
0
0
11
0.00
0.21
0.0
1.3
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
8
104
0.76
0.21
1.1
1.1
—
—
—
0
0
0
12
0.00
0.21
0.0
1.1
—
—
—
0
0
0
12
0.00
0.21
0.0
1.6
—
—
—
0
0
0
13
0.00
0.21
0.0
1.3
—
135.28
—
0
13
0
13
0.00
0.21
0.0
1.0
—
1383.77
—
0
13
0
13
0.00
0.21
0.0
1.1
—
—
—
0
0
0
14
0.00
0.20
0.0
1.4
—
—
—
0
0
17
197
0.86
0.20
3.9
3.7
—
—
—
0
0
100
954
1.07
0.20
2.3
2.7
—
—
—
0
0
6
51
1.18
0.19
1.7
1.6
—
—
—
0
0
5
67
0.74
0.17
1.4
1.4
8.57
10.46
u/l
—
5
60
12
101
1.20
0.17
1.4
1.7
—
—
—
0
0
32
293
1.10
0.16
3.2
2.5
0.78
0.93
ug/l
0.35
19
182
8
71
1.13
0.16
1.1
1.1
1.16
1.22
g/l
—
8
65
12
102
1.18
0.15
1.4
1.7
—
—
—
0
0
60
630
0.94
0.13
1.8
1.6
1.33
1.38
mmol/l
0.17
53
510
11
94
1.18
0.13
1.6
1.2
—
—
—
0
0
25
229
1.10
0.13
1.6
1.5
—
—
—
0
0
11
95
1.16
0.12
1.5
1.7
—
—
—
0
0
12
107
1.13
0.08
4.3
10.3
—
—
—
0
0
13
117
1.12
0.08
2.5
2.3
—
—
—
0
0
46
441
1.05
0.08
2.1
1.8
—
—
—
0
0
65
634
1.03
0.05
3.5
2.8
—
—
—
0
0
23
218
1.06
0.05
4.2
3.2
5.88
5.83
kpa
0.09
23
206
10
110
0.91
0.05
2.0
3.4
24.88
24.68
mmol/l
—
10
105
24
229
1.05
0.04
1.6
1.3
—
—
—
0
0
11
101
1.09
0.04
1.5
1.7
—
—
—
0
0
223
2216
1.02
0.04
20.7
15.8
331.89
332.37
g/l
0.37
223
2203
39
380
1.03
0.03
3.2
2.4
1.12
2.74
e6/l
2.41
20
180
34
331
1.03
0.02
1.3
1.3
—
—
—
0
0
19
182
1.05
0.02
4.1
2.6
4.45
4.63
kpa
0.19
19
172
0
9
0.00
0.00
0.0
1.2
—
—
—
0
0
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
6
64
0.94
0.00
1.3
1.2
—
—
—
0
0
8
79
1.01
0.00
1.6
1.5
—
—
—
0
0
0
9
0.00
0.00
0.0
1.2
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.9
—
—
—
0
0
0
7
0.00
-0.00
0.0
2.4
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.7
—
—
—
0
0
0
5
0.00
-0.00
0.0
8.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
10
100
1.00
-0.00
1.3
1.7
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
10
100
1.00
-0.00
1.3
1.7
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
3.2
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.4
—
—
—
0
0
8
80
1.00
-0.00
1.1
1.3
—
—
—
0
0
7
69
1.01
-0.00
1.4
2.7
—
—
—
0
0
8
82
0.97
-0.00
7.6
7.0
—
—
—
0
0

Mortality – FinRegistry

↥

Association

Association between endpoint M13_ANKLEFOOT and mortality.

Females

Parameter HR [95% CI] p-value
M13_ANKLEFOOT 0.955 [0.74, 1.23] 0.72
Birth year 0.996 [0.99, 1.0] 0.354

During the follow-up period (1.1.1998 — 31.12.2019), 83 out of 876 females with M13_ANKLEFOOT died.

Males

No data

Mortality risk

Mortality risk for people of age

years, who have M13_ANKLEFOOT.

N-year risk Females Males
1 0.109% No data
5 0.579% No data
10 1.411% No data
15 2.842% No data
20 5.145% No data

Relationships between endpoints

↥

Index endpoint: M13_ANKLEFOOT – Other acquired deformities of ankle and foot

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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