Multifocal fibrosclerosis

M13_MULTIFIBRO

multiple sclerosis: A progressive autoimmune disorder affecting the central nervous system resulting in demyelination. Patients develop physical and cognitive impairments that correspond with the affected nerve fibers.

Suggest a new description

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 M35.5
  • Cause of death: ICD-10 M35.5

2 out of 7 registries used, show all original rules.

224

4. Check minimum number of events

None

224

5. Include endpoints

None

224

6. Filter based on genotype QC (FinnGen only)

224

Control definitions (FinnGen only)

Control exclude
M13_SYSTCONNECT

Extra metadata

Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
M35
Name in latin
Fibrosclerosis multifocalis

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 1805 1278 511
Only index persons 1554 1106 448
Unadjusted period prevalence (%)
Whole population 0.03 0.04 0.01
Only index persons 0.03 0.04 0.02
Median age at first event (years)
Whole population 72.13 72.44 71.18
Only index persons 70.74 71.06 69.95

-FinnGen-

Key figures

All Female Male
Number of individuals 224 151 73
Unadjusted period prevalence (%) 0.05 0.05 0.03
Median age at first event (years) 63.18 61.22 67.24

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
201
Matched controls
2009
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
M35.5
ICD-10 Finland
Multifocal fibrosclerosis
+∞
291.0
201
*
M35.3
ICD-10 Finland
Polymyalgia rheumatica
191.6
122.9
119
15
H02AB06
ATC
prednisolone; systemic
8.4
38.3
163
679
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
9.9
33.0
73
109
M35.9
ICD-10 Finland
Systemic involvement of connective tissue, unspecified
+∞
29.9
28
*
M35.0
ICD-10 Finland
Sicca syndrome [Sjögren]
310.3
27.4
27
*
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
5.2
26.7
134
557
M31.5
ICD-10 Finland
Giant cell arteritis with polymyalgia rheumatica
271.0
24.2
24
*
L04AX03
ATC
methotrexate; systemic (immunosuppressants)
8.5
22.8
53
81
NK4XE
NOMESCO Finland
Joint ultrasound examination not elsewhere classified
10.9
20.9
41
46
TNX10
NOMESCO Finland
Arthrocentesis, unspecified region, unspecified region
8.7
20.4
46
66
P01BA02
ATC
hydroxychloroquine; oral
8.1
20.2
48
75
H02AB07
ATC
prednisone; oral
5.1
18.3
66
176
PAW37
NOMESCO Finland
Biopsy of temporal artery
196.6
17.8
18
*
L88
ICPC
Rheumatoid/seropositive arthritis
12.0
16.9
31
30
M35.1
ICD-10 Finland
Other overlap syndromes
+∞
16.9
16
*
M05BA04
ATC
alendronic acid; oral
4.7
12.6
46
120
M25.5
ICD-10 Finland
Pain in joint
3.2
12.2
83
364
N03AX16
ATC
pregabalin; oral
3.2
11.5
76
323
N02AX02
ATC
tramadol; systemic, rectal
2.8
10.9
109
599
M79.1
ICD-10 Finland
Myalgia
4.1
10.2
42
122
M06.9
ICD-10 Finland
Rheumatoid arthritis, unspecified
9.5
10.1
20
23
L04AX01
ATC
azathioprine; systemic
7.8
9.8
22
31
M13.9
ICD-10 Finland
Arthritis, unspecified
5.2
9.6
30
66
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
2.6
9.5
112
661
R70.0
ICD-10 Finland
Elevated erythrocyte sedimentation rate
11.5
9.5
17
16
A02BC02
ATC
pantoprazole; systemic
2.8
9.5
155
1097
NK6QA
NOMESCO Finland
Measurement of bone density from tow or more locations with X-ray
5.4
9.4
28
58
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.5
9.1
111
659
M05BA07
ATC
risedronic acid; oral
6.8
8.6
21
34
H04.10
ICD-10 Finland
Dry eye syndrome
4.1
8.5
33
91
M35.7
ICD-10 Finland
Hypermobility syndrome
+∞
8.4
8
*
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
2.4
8.3
108
653
H02AB04
ATC
methylprednisolone; systemic
3.1
7.8
46
175
M01AE02
ATC
naproxen; oral, rectal
2.3
7.6
124
823
J01DB01
ATC
cefalexin; oral
2.9
7.6
172
1357
L01BA01
ATC
methotrexate; systemic (folic acid analog.)
6.0
7.6
20
36
A07EC01
ATC
sulfasalazine; oral, rectal
4.2
7.3
27
71
J20.9
ICD-10 Finland
Acute bronchitis, unspecified
2.8
7.3
51
219
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
3.2
7.1
39
141
M05.8
ICD-10 Finland
Other seropositive rheumatoid arthritis
4.6
7.1
24
58
M03BC51
ATC
orphenadrine, combinations; systemic
2.5
7.1
67
338
NH3AA
NOMESCO Finland
Foot and toes X-ray examination
3.7
7.0
30
91
J01FA10
ATC
azithromycin; systemic
2.2
6.8
118
792
ND2AA
NOMESCO Finland
Hand and fingers X-ray examination
3.7
6.7
29
88
A46
ICD-10 Finland
Erysipelas
2.9
6.6
42
169
M54.5
ICD-10 Finland
Low back pain
2.3
6.6
81
462
NB1AA
NOMESCO Finland
Shoulder X-ray examination without contrast
4.3
6.4
23
59
M79.7
ICD-10 Finland
Fibromyalgia
6.7
6.3
15
24
H35.5
ICD-10 Finland
Hereditary retinal dystrophy
+∞
6.3
6
*
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
2.2
6.2
85
506
J45.9
ICD-10 Finland
Asthma, unspecified
2.6
6.1
49
223
R07.4
ICD-10 Finland
Chest pain, unspecified
2.3
6.1
69
377
R50.9
ICD-10 Finland
Fever, unspecified
2.9
6.1
38
151

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
74
194
5.20
27.70
1.7
1.3
788.3
351.1
titre
1.11
24
45
139
596
4.51
27.32
9.8
4.6
—
—
—
0
0
84
271
4.36
23.80
1.3
1.3
10.4
16.4
u/ml
0.42
23
99
159
818
4.25
22.74
12.5
5.1
0.5
0.6
%
1.78
153
750
85
290
4.11
22.10
1.5
1.2
36.3
42.1
iu/ml
0.18
27
94
165
888
4.26
21.70
12.3
5.0
0.0
0.0
e9/l
0.21
149
761
159
836
4.11
21.60
12.6
5.1
2.4
2.7
%
1.14
153
766
164
882
4.21
21.52
12.3
5.0
0.6
0.6
e9/l
1.01
148
754
159
841
4.07
21.29
12.8
5.4
8.5
8.6
%
0.15
153
778
167
915
4.24
21.19
12.4
5.3
0.2
0.2
e9/l
0.64
151
796
159
854
3.97
20.50
13.0
5.3
25.4
27.0
%
0.97
152
786
158
846
3.94
20.45
12.5
5.1
60.8
58.1
%
1.72
152
785
164
904
4.04
20.23
12.7
5.0
1.8
1.8
e9/l
0.36
147
794
16
12
14.28
16.97
3.5
1.6
—
—
—
0
0
115
576
3.05
15.13
3.3
2.0
402.9
215.3
u/l
0.32
102
538
168
1059
3.35
14.35
14.3
8.8
4.6
4.2
e9/l
1.64
152
919
184
1255
3.61
13.16
7.3
4.5
—
—
—
0
0
147
909
2.80
12.06
4.8
4.0
0.0
0.0
estimate
0.00
39
181
152
957
2.83
12.03
7.7
6.1
1.2
1.2
mmol/l
0.41
134
799
191
1368
3.69
11.87
13.0
3.8
14.1
13.3
mm/h
0.30
178
1241
144
893
2.72
11.55
4.7
4.0
0.0
0.0
estimate
0.00
34
191
144
901
2.68
11.21
6.1
5.3
0.0
0.0
estimate
0.00
38
186
45
152
3.45
11.19
1.8
2.9
65.9
66.4
g/l
0.15
40
133
41
132
3.58
10.96
8.9
4.2
0.0
0.0
%
0.00
11
37
92
469
2.63
10.88
2.8
2.7
3835.1
10470.3
umol/l
0.83
81
386
39
129
3.45
9.97
6.9
4.0
0.1
0.6
%
—
7
32
38
124
3.49
9.92
4.8
3.0
10.5
10.0
g/l
0.32
38
110
27
71
4.19
9.55
2.2
2.0
—
—
—
0
0
39
133
3.34
9.49
1.6
2.7
—
—
—
0
0
136
881
2.38
9.05
6.8
5.6
1.2
1.2
mmol/l
0.14
126
796
24
62
4.22
8.67
1.3
2.6
37.3
37.8
g/l
0.14
19
49
131
851
2.30
8.44
4.9
4.0
34.8
34.9
g/l
0.04
120
790
38
137
3.14
8.41
9.7
4.1
0.0
0.2
%
—
9
41
189
1448
2.95
8.41
12.0
6.9
76.8
79.9
u/l
0.34
179
1343
110
672
2.25
8.13
5.6
3.8
116.8
86.1
e6/l
0.25
88
490
32
107
3.32
8.00
2.2
1.7
1.1
1.5
g/l
0.71
32
93
14
24
6.16
7.95
1.9
1.7
—
—
—
0
0
49
210
2.71
7.93
1.6
1.7
—
—
—
0
0
82
448
2.31
7.88
5.2
3.5
90.7
89.7
%
0.11
82
438
83
457
2.30
7.82
8.5
6.7
—
—
—
0
0
13
21
6.51
7.80
1.2
1.8
—
—
—
0
0
99
587
2.23
7.79
4.3
3.3
44.1
186.7
e6/l
0.68
85
454
57
266
2.53
7.76
2.8
2.3
22.2
21.4
%
0.17
52
235
39
150
2.94
7.70
9.5
3.9
0.6
1.0
%
—
9
48
14
25
5.91
7.64
1.4
1.1
—
—
—
0
0
39
151
2.92
7.61
1.4
1.6
—
—
—
0
0
86
486
2.25
7.57
2.5
2.1
3.2
3.3
mg/l
0.23
68
412
122
799
2.16
7.35
16.6
10.3
0.0
0.0
e9/l
0.41
109
642
15
30
5.29
7.29
1.7
1.7
—
—
—
0
0
120
786
2.13
7.17
2.5
2.0
90.8
95.4
pmol/l
0.57
63
378
74
401
2.26
7.14
3.9
3.9
—
—
—
0
0
29
99
3.22
7.00
1.2
1.4
—
—
—
0
0
17
40
4.52
6.88
1.3
1.7
—
—
—
0
0
37
151
2.74
6.52
4.1
3.2
77.7
87.6
ng/l
0.47
32
130
103
663
2.02
6.19
2.7
3.1
2.4
2.4
mmol/l
0.02
87
577
66
361
2.17
6.11
4.8
3.6
74.9
150.9
ng/l
0.58
53
293
45
210
2.43
6.03
1.6
1.8
—
—
—
0
0
64
348
2.17
6.00
2.0
1.4
2.3
2.6
g/l
0.59
42
203
47
225
2.38
5.95
2.9
2.9
1.4
1.8
%
3.10
41
203
73
421
2.09
5.86
3.5
2.7
3.6
4.9
e6/l
0.82
62
375
138
1004
1.98
5.66
5.4
5.8
9.7
10.9
umol/l
1.67
127
944
87
543
1.98
5.57
5.9
4.0
—
—
—
0
0
40
184
2.43
5.51
1.5
1.6
—
—
—
0
0
176
1405
2.18
5.46
5.2
4.1
15.3
14.9
pmol/l
0.96
157
1244
116
805
1.91
5.38
10.3
9.2
1.3
1.3
inr
0.09
28
246
92
594
1.93
5.28
2.8
2.3
69.6
55.5
u/l
0.89
83
539
10
19
5.46
5.09
2.9
2.8
—
—
—
0
0
112
779
1.88
5.06
3.4
2.6
110.0
121.6
ug/l
0.33
101
706
82
517
1.92
5.00
4.2
3.0
—
—
—
0
0
66
387
2.00
4.96
2.9
3.0
2.5
2.5
mmol/l
0.05
53
341
49
259
2.14
4.85
1.2
1.2
—
—
—
0
0
68
406
1.97
4.85
3.5
2.9
515.7
532.7
mosm/kgh2o
0.36
55
348
84
539
1.89
4.83
4.3
3.0
0.2
0.6
e6/l
2.11
71
404
92
611
1.86
4.73
4.9
4.1
7.4
7.4
ph
0.10
14
122
145
1115
1.85
4.57
6.0
4.5
6.8
6.7
mmol/l
0.18
139
1033
207
1814
2.86
4.49
30.7
15.0
18.1
23.5
mg/l
2.25
181
1450
95
652
1.79
4.30
3.5
3.5
—
—
—
0
0
51
286
2.01
4.29
2.1
2.0
—
—
—
0
0
9
13
7.16
4.20
1.3
1.1
—
—
—
0
0
51
290
1.98
4.12
3.1
3.2
0.8
0.8
mmol/l
0.23
46
271
23
94
2.61
4.03
2.7
2.5
—
—
—
0
0
62
382
1.86
3.93
10.2
4.9
—
—
—
0
0
65
407
1.84
3.92
1.8
1.6
1.5
1.3
mg/l
0.14
52
326
65
410
1.82
3.82
1.8
1.7
1125.2
1221.7
nmol/l
0.35
53
304
30
144
2.25
3.74
5.8
5.6
9.7
10.0
mmol/l
0.13
30
134
32
160
2.17
3.62
2.0
2.7
61.3
71.3
e9/l
1.14
24
127
102
742
1.69
3.60
2.3
2.2
—
—
—
0
0
7
9
7.98
3.58
1.4
1.3
—
—
—
0
0
9
17
5.47
3.55
1.1
1.2
—
—
—
0
0
191
1664
2.00
3.42
6.7
4.9
1.7
2.0
mu/l
4.02
175
1484
83
580
1.68
3.35
2.6
2.3
—
—
—
0
0
60
383
1.77
3.35
1.4
1.2
1.2
1.8
u/ml
0.43
12
108
27
130
2.22
3.35
1.1
1.1
—
—
—
0
0
40
226
1.94
3.27
1.3
1.3
—
—
—
0
0
32
172
2.00
3.01
4.8
4.0
—
—
—
0
0
5
5
10.18
2.99
1.2
1.4
—
—
—
0
0
80
569
1.63
2.96
4.9
4.2
—
—
—
0
0
37
213
1.88
2.86
1.7
1.3
—
—
—
0
0
69
479
1.64
2.78
2.0
1.5
22.2
21.4
nmol/l
0.16
59
393
7
14
5.12
2.75
1.3
1.1
—
—
—
0
0
73
520
1.60
2.64
5.3
4.2
0.0
0.0
estimate
0.00
38
178
12
44
2.83
2.59
1.2
1.1
—
—
—
0
0
25
130
2.04
2.57
3.3
2.8
—
—
—
0
0
6
11
5.57
2.56
1.2
1.2
—
—
—
0
0
15
63
2.48
2.52
4.3
3.0
—
—
—
0
0
11
39
2.91
2.51
2.8
2.2
—
—
—
0
0
9
26
3.56
2.51
2.0
3.3
1.9
2.0
%
—
9
21
72
518
1.57
2.47
4.7
3.7
—
—
—
0
0
6
12
5.10
2.41
1.0
1.1
—
—
—
0
0
204
1872
2.01
2.35
26.6
18.0
139.8
139.7
mmol/l
0.13
196
1816
14
59
2.46
2.34
1.9
1.5
235.5
275.5
ug/g
—
8
36
9
28
3.30
2.33
8.9
2.5
5.5
5.4
e9/l
—
9
28
28
159
1.87
2.26
2.7
2.9
177.9
262.8
ng/l
0.63
23
143
204
1877
1.97
2.25
26.9
18.1
4.0
4.0
mmol/l
0.85
195
1818
9
29
3.19
2.25
9.0
3.1
61.0
62.9
%
—
9
29
17
81
2.19
2.19
4.8
3.5
—
—
—
0
0
13
55
2.45
2.16
1.6
1.6
—
—
—
0
0
30
177
1.80
2.16
2.2
2.5
7.7
4.9
ug/l
0.45
22
151
25
139
1.90
2.15
1.2
1.4
—
—
—
0
0
10
37
2.78
2.13
1.2
1.5
—
—
—
0
0
5
10
5.09
2.08
1.2
1.3
—
—
—
0
0
7
20
3.58
2.07
1.1
1.1
—
—
—
0
0
36
228
1.69
2.04
7.9
5.8
2.2
1.5
mmol/l
0.52
28
180
8
26
3.15
2.03
1.1
1.5
29.6
31.8
pg
—
8
26
18
92
2.04
1.96
11.9
7.1
—
—
—
0
0
17
85
2.08
1.96
3.3
3.5
24.7
24.6
mmol/l
0.08
17
78
8
27
3.03
1.95
1.0
1.2
—
—
—
0
0
6
16
3.82
1.95
1.7
1.4
—
—
—
0
0
6
16
3.82
1.95
1.7
1.4
—
—
—
0
0
6
16
3.82
1.95
1.7
1.4
—
—
—
0
0
6
16
3.82
1.95
1.7
1.4
—
—
—
0
0
41
274
1.61
1.89
25.0
24.5
1.8
1.3
inr
—
5
29
5
12
4.23
1.83
1.6
1.3
—
—
—
0
0
15
74
2.10
1.79
2.1
2.7
—
—
—
0
0
56
411
1.48
1.71
4.4
4.1
1.0
1.0
kg/l
—
8
59
32
207
1.64
1.68
2.7
2.1
208.2
151.4
ug/g
0.30
27
162
203
1896
1.75
1.67
30.9
18.0
82.4
77.7
umol/l
1.05
203
1896
7
26
2.75
1.59
1.1
1.1
—
—
—
0
0
70
545
1.41
1.56
4.0
3.0
6.7
7.0
mmol/l
0.28
59
455
11
51
2.22
1.53
1.0
1.1
—
—
—
0
0
5
15
3.38
1.53
1.4
1.9
—
—
—
0
0
72
565
1.40
1.53
4.8
3.9
7.3
8.5
mg/mmol
0.19
47
351
7
27
2.64
1.52
1.4
2.1
61.9
58.6
%
—
7
27
18
103
1.81
1.46
1.5
1.2
—
32.9
—
0
8
199
1864
1.61
1.43
21.8
14.6
—
—
—
0
0
10
46
2.23
1.42
2.1
6.2
—
—
—
0
0
202
1903
1.63
1.36
19.5
10.3
25.9
23.6
u/l
0.95
194
1825
5
18
2.82
1.29
1.0
1.2
—
—
—
0
0
18
108
1.72
1.26
1.1
1.2
28.5
120.8
iu/ml
—
6
43
207
1968
1.68
1.25
40.4
22.4
260.1
247.2
e9/l
1.73
201
1912
9
45
2.04
1.25
1.4
1.3
—
—
—
0
0
96
812
1.32
1.22
5.6
4.2
25.5
42.6
ng/l
1.75
71
586
5
19
2.67
1.22
1.4
1.1
—
—
—
0
0
207
1970
1.67
1.22
40.1
22.3
30.2
30.3
pg
0.44
202
1930
207
1970
1.67
1.22
40.3
22.3
91.7
91.4
fl
0.44
202
1930
207
1970
1.67
1.22
40.3
22.4
4.4
4.4
e12/l
0.57
200
1909
207
1970
1.67
1.22
40.4
22.4
7.4
6.6
e9/l
5.51
200
1910
207
1971
1.66
1.20
40.8
22.5
130.1
132.4
g/l
1.62
202
1930
6
26
2.34
1.19
1.2
1.0
—
—
—
0
0
182
1691
1.41
1.18
7.6
6.1
41.7
40.6
mmol/mol
0.85
166
1553
31
218
1.49
1.17
1.4
1.3
—
—
—
0
0
5
20
2.53
1.15
4.8
3.2
—
—
—
0
0
7
30
2.38
1.13
1.3
1.4
—
—
—
0
0
143
1287
1.31
1.12
4.8
4.1
—
—
—
0
0
66
536
1.33
1.10
4.1
3.1
44.0
281.6
mg/l
0.81
45
346
187
1752
1.41
1.10
5.8
4.8
5.8
6.0
mmol/l
1.26
171
1571
12
68
1.81
1.02
3.8
3.3
0.2
0.3
g/l
—
5
24
7
37
1.92
0.95
2.3
2.8
—
—
—
0
0
9
52
1.76
0.93
1.0
1.2
—
—
—
0
0
179
1680
1.33
0.91
4.6
4.1
1.3
1.2
mmol/l
0.91
162
1500
8
42
1.94
0.89
1.4
1.4
27.6
22.4
iu/l
—
8
35
6
30
2.03
0.87
1.2
1.2
12.9
9.0
u/l
—
6
23
8
45
1.81
0.85
4.3
2.3
2.2
1.6
mg/l
—
8
40
16
107
1.53
0.78
3.0
4.4
—
—
—
0
0
23
167
1.42
0.77
3.4
3.4
—
—
—
0
0
21
150
1.44
0.76
11.7
7.1
—
—
—
0
0
167
1568
1.26
0.75
28.5
16.2
38.6
39.0
%
0.25
122
1056
19
135
1.45
0.72
3.7
3.5
—
—
—
0
0
184
1751
1.28
0.71
5.1
4.6
4.6
4.6
mmol/l
0.08
172
1588
183
1741
1.28
0.70
5.1
4.6
1.5
1.5
mmol/l
1.15
170
1567
25
188
1.37
0.70
3.4
3.4
—
—
—
0
0
23
171
1.38
0.69
5.6
4.0
—
—
—
0
0
16
112
1.46
0.65
4.8
2.5
3.9
3.8
e9/l
0.06
11
81
49
574
0.81
0.60
3.2
3.3
—
—
—
0
0
7
111
0.62
0.60
1.4
1.3
—
—
—
0
0
0
22
0.00
0.59
0.0
1.0
—
—
—
0
0
12
81
1.51
0.58
2.5
1.9
1.1
4.8
ug/l
0.50
12
69
6
36
1.68
0.57
3.7
2.6
—
—
—
0
0
55
474
1.21
0.56
1.5
1.6
1.5
1.3
mmol/l
0.70
48
391
9
61
1.50
0.54
1.3
1.2
—
—
—
0
0
50
429
1.21
0.54
1.7
1.8
448.8
471.4
pmol/l
0.17
42
358
52
448
1.21
0.53
1.5
1.4
—
—
—
0
0
51
444
1.19
0.47
4.9
5.5
2.3
2.9
ug/l
0.29
45
385
7
48
1.47
0.47
3.3
2.4
7.7
7.9
kpa
—
7
41
7
51
1.38
0.44
1.9
2.6
—
—
—
0
0
186
1798
1.20
0.44
5.7
5.2
2.7
2.7
mmol/l
0.20
174
1618
20
158
1.29
0.43
1.6
1.7
—
—
—
0
0
0
16
0.00
0.41
0.0
1.3
—
—
—
0
0
26
218
1.22
0.36
1.9
4.1
3.8
38.8
ug/l
0.60
18
185
6
42
1.44
0.36
3.0
2.5
—
—
—
0
0
14
109
1.30
0.34
1.1
1.3
—
—
—
0
0
9
117
0.76
0.28
1.6
1.4
—
—
—
0
0
6
82
0.72
0.24
3.0
4.2
—
—
—
0
0
0
10
0.00
0.21
0.0
10.4
—
0.7
—
0
10
0
14
0.00
0.20
0.0
1.1
—
—
—
0
0
11
90
1.23
0.19
1.7
1.6
—
—
—
0
0
12
100
1.21
0.18
1.8
1.2
—
—
—
0
0
5
67
0.74
0.17
27.8
10.6
—
—
—
0
0
17
149
1.15
0.16
1.7
1.5
—
—
—
0
0
9
80
1.13
0.15
1.2
1.2
—
—
—
0
0
27
253
1.08
0.09
3.1
3.1
0.9
0.8
ug/l
0.23
18
168
5
60
0.83
0.08
1.2
1.3
—
—
—
0
0
6
70
0.85
0.08
3.0
5.3
—
—
—
0
0
10
107
0.93
0.02
1.8
2.5
1.2
1.1
%
—
10
107
18
175
1.03
0.00
1.2
1.3
—
—
—
0
0
0
7
0.00
0.00
0.0
1.4
—
—
—
0
0
6
69
0.87
0.00
2.8
3.6
3.9
4.0
mmol/l
—
6
61
0
7
0.00
0.00
0.0
2.1
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
15.0
—
2346.0
—
0
8
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.6
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
6
65
0.92
0.00
1.2
1.9
—
—
—
0
0
0
8
0.00
0.00
0.0
12.5
—
1168.1
—
0
8
0
6
0.00
0.00
0.0
1.0
—
19.2
—
0
6
0
8
0.00
0.00
0.0
1.6
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
2.0
—
—
—
0
0

Mortality – FinRegistry

Association

Association between endpoint M13_MULTIFIBRO and mortality.

Females

Parameter HR [95% CI] p-value
M13_MULTIFIBRO 1.619 [1.38, 1.9] < 0.001
Birth year 0.99 [0.98, 1.0] 0.019

During the follow-up period (1.1.1998 — 31.12.2019), 528 out of 1187 females with M13_MULTIFIBRO died.

Males

Parameter HR [95% CI] p-value
M13_MULTIFIBRO 1.371 [1.09, 1.72] 0.006
Birth year 0.988 [0.98, 1.0] 0.015

During the follow-up period (1.1.1998 — 31.12.2019), 229 out of 481 males with M13_MULTIFIBRO died.

Mortality risk

Mortality risk for people of age

years, who have M13_MULTIFIBRO.

N-year risk Females Males
1 0.105% 0.27%
5 0.745% 1.63%
10 1.866% 3.975%
15 3.45% 7.504%
20 6.278% 13.11%

Relationships between endpoints

Index endpoint: M13_MULTIFIBRO – Multifocal fibrosclerosis

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
loading spinner Loading data