multiple sclerosis: A progressive autoimmune disorder affecting the central nervous system resulting in demyelination. Patients develop physical and cognitive impairments that correspond with the affected nerve fibers.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
224 |
4. Check minimum number of eventsNone |
224 |
5. Include endpointsNone |
224 |
6. Filter based on genotype QC (FinnGen only) |
224 |
Control definitions (FinnGen only)
- Control exclude
- M13_SYSTCONNECT
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- M35
- Name in latin
- Fibrosclerosis multifocalis
Similar endpoints
↥List of similar endpoints to Multifocal fibrosclerosis based on the number of shared cases.
Similar with more cases:
- Other systemic involvement of connective tissue
- Systemic connective tissue disorders
- Diseases of the musculoskeletal system and connective tissue
- Any operation in hilmo
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥Summary Statistics
↥-FinRegistry-
Key figures
All | Female | Male | |
---|---|---|---|
Number of individuals | |||
Whole population | 1805 | 1278 | 511 |
Only index persons | 1554 | 1106 | 448 |
Unadjusted period prevalence (%) | |||
Whole population | 0.03 | 0.04 | 0.01 |
Only index persons | 0.03 | 0.04 | 0.02 |
Median age at first event (years) | |||
Whole population | 72.13 | 72.44 | 71.18 |
Only index persons | 70.74 | 71.06 | 69.95 |
-FinnGen-
Key figures
All | Female | Male | |
---|---|---|---|
Number of individuals | 224 | 151 | 73 |
Unadjusted period prevalence (%) | 0.05 | 0.05 | 0.03 |
Median age at first event (years) | 63.18 | 61.22 | 67.24 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 201
- Matched controls
- 2009
LabWAS
↥Mortality – FinRegistry
↥Association
Association between endpoint M13_MULTIFIBRO and mortality.
Females
Parameter | HR [95% CI] | p-value |
---|---|---|
M13_MULTIFIBRO | 1.619 [1.38, 1.9] | < 0.001 |
Birth year | 0.99 [0.98, 1.0] | 0.019 |
During the follow-up period (1.1.1998 — 31.12.2019), 528 out of 1187 females with M13_MULTIFIBRO died.
Males
Parameter | HR [95% CI] | p-value |
---|---|---|
M13_MULTIFIBRO | 1.371 [1.09, 1.72] | 0.006 |
Birth year | 0.988 [0.98, 1.0] | 0.015 |
During the follow-up period (1.1.1998 — 31.12.2019), 229 out of 481 males with M13_MULTIFIBRO died.
Mortality risk
Mortality risk for people of age
years, who have M13_MULTIFIBRO.N-year risk | Females | Males |
---|---|---|
1 | 0.105% | 0.27% |
5 | 0.745% | 1.63% |
10 | 1.866% | 3.975% |
15 | 3.45% | 7.504% |
20 | 6.278% | 13.11% |
Relationships between endpoints
↥Index endpoint: M13_MULTIFIBRO – Multifocal fibrosclerosis
GWS hits: -