multiple sclerosis: A progressive autoimmune disorder affecting the central nervous system resulting in demyelination. Patients develop physical and cognitive impairments that correspond with the affected nerve fibers.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519972 |
1. Apply sex-specific ruleNone |
519972 |
2. Check conditionsNone |
519972 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
228 |
4. Check minimum number of eventsNone |
228 |
5. Include endpointsNone |
228 |
6. Filter based on genotype QC (FinnGen only) |
223 |
Control definitions (FinnGen only)
- Control exclude
- M13_SYSTCONNECT
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- M35
- Name in latin
- Fibrosclerosis multifocalis
Similar endpoints
↥List of similar endpoints to
Multifocal fibrosclerosis
based on the number of shared cases.
Similar with more cases:
- Other systemic involvement of connective tissue
- Systemic connective tissue disorders
- Diseases of the musculoskeletal system and connective tissue
- Any operation in hilmo
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1805 | 1278 | 511 |
| Only index persons | 1554 | 1106 | 448 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.03 | 0.04 | 0.01 |
| Only index persons | 0.03 | 0.04 | 0.02 |
| Median age at first event (years) | |||
| Whole population | 72.13 | 72.44 | 71.18 |
| Only index persons | 70.74 | 71.06 | 69.95 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 223 | 152 | 71 |
| Unadjusted period prevalence (%) | 0.05 | 0.05 | 0.03 |
| Median age at first event (years) | 63.47 | 61.72 | 67.21 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 228
- Matched controls
- 2280
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
M35.5
ICD-10 Finland
Multifocal fibrosclerosis
+∞
307.7
228
*
M35.3
ICD-10 Finland
Polymyalgia rheumatica
167.0
266.0
136
20
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
10.1
60.0
87
131
L04AX03
ATC
methotrexate; systemic
8.7
45.1
69
108
H02AB06
ATC
prednisolone; systemic
9.0
43.2
190
816
NK4XE
NOMESCO Finland
Joint ultrasound examination not elsewhere classified
10.9
43.2
52
60
L88
ICPC
Rheumatoid/seropositive arthritis
11.6
34.9
39
40
TNX10
NOMESCO Finland
Arthrocentesis, unspecified region, unspecified region
8.4
34.3
51
76
M35.9
ICD-10 Finland
Systemic involvement of connective tissue, unspecified
+∞
34.2
32
*
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
5.2
31.6
159
696
P01BA02
ATC
hydroxychloroquine; oral
7.1
30.8
54
96
H02AB07
ATC
prednisone; oral
5.4
29.0
74
187
M31.5
ICD-10 Finland
Giant cell arteritis with polymyalgia rheumatica
318.5
28.4
28
*
M35.0
ICD-10 Finland
Sicca syndrome [Sjögren]
114.6
28.4
30
*
M05BA04
ATC
alendronic acid; oral
5.4
24.8
59
139
N03AX16
ATC
[U] pregabalin
3.8
20.6
92
345
PAW37
NOMESCO Finland
Biopsy of temporal artery
218.2
19.9
20
*
M25.5
ICD-10 Finland
Pain in joint
3.3
16.9
104
467
M35.1
ICD-10 Finland
Other overlap syndromes
+∞
16.9
16
*
L04AX01
ATC
azathioprine; systemic
11.6
14.2
26
25
M13.9
ICD-10 Finland
Arthritis, unspecified
4.7
13.5
34
82
A02BC02
ATC
pantoprazole; systemic
3.6
13.2
187
1280
M06.9
ICD-10 Finland
Rheumatoid arthritis, unspecified
6.5
12.8
22
37
N02AX02
ATC
tramadol; systemic, rectal
2.8
12.8
127
713
M79.1
ICD-10 Finland
Myalgia
3.4
12.4
52
181
M05BA07
ATC
risedronic acid; oral
5.6
12.0
24
47
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
3.5
11.9
47
157
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
3.0
11.7
63
254
M35.7
ICD-10 Finland
Hypermobility syndrome
126.1
11.5
12
*
NH3AA
NOMESCO Finland
Foot and toes X-ray examination
4.0
11.4
35
98
J45.9
ICD-10 Finland
Asthma, unspecified
2.9
10.9
67
290
M54.5
ICD-10 Finland
Low back pain
2.6
10.6
98
519
NK6QA
NOMESCO Finland
Measurement of bone density from two or more locations with X-ray
4.0
10.4
32
90
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.5
10.2
134
830
M54.9
ICD-10 Finland
Dorsalgia, unspecified
3.3
10.1
44
156
L01BA01
ATC
methotrexate; systemic
7.7
9.8
22
31
H02AB04
ATC
methylprednisolone; systemic
3.0
9.7
51
201
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.5
9.6
92
492
A07EC01
ATC
sulfasalazine; oral, rectal
3.7
9.3
31
92
EB1AA
NOMESCO Finland
Intraoral radiographic dental examination
2.3
9.0
132
842
R70.0
ICD-10 Finland
Elevated erythrocyte sedimentation rate
9.2
9.0
18
21
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
2.3
8.7
122
760
M48.0
ICD-10 Finland
Spinal stenosis
2.9
8.7
46
182
A46
ICD-10 Finland
Erysipelas
2.8
8.6
51
214
M51.3
ICD-10 Finland
Other specified intervertebral disc degeneration
3.8
8.5
28
82
N03AX12
ATC
[U] gabapentin; oral
2.7
8.4
55
243
R50.9
ICD-10 Finland
Fever, unspecified
2.8
8.3
46
186
A01
ICPC
Pain general/multiple sites
3.0
8.3
40
150
NB1AA
NOMESCO Finland
Shoulder X-ray examination without contrast
3.4
8.0
30
96
J20.9
ICD-10 Finland
Acute bronchitis, unspecified
2.5
7.9
63
306
R4110
NOMESCO Finland
Physiotherapy
2.3
7.8
82
449
H04.10
ICD-10 Finland
Dry eye syndrome
2.9
7.8
40
155
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
2.2
7.7
129
851
ND2AA
NOMESCO Finland
Hand and fingers X-ray examination
3.1
7.4
33
118
M01AH05
ATC
etoricoxib; oral
2.2
7.3
145
1015
ZX120
NOMESCO Finland
Intravenous
2.9
7.1
36
138
A49.9
ICD-10 Finland
Bacterial infection, unspecified
2.7
7.1
42
175
M01AE02
ATC
naproxen; oral, rectal
2.1
7.1
142
991
Z01.8
ICD-10 Finland
Other specified special examinations
2.4
7.0
61
306
L97
ICD-10 Finland
Ulcer of lower limb, not elsewhere classified
4.4
7.0
18
44
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
2.1
6.9
94
566
I77.6
ICD-10 Finland
Arteritis, unspecified
41.3
6.8
8
*
R07.4
ICD-10 Finland
Chest pain, unspecified
2.1
6.7
85
496
J01DB01
ATC
cefalexin; oral
2.7
6.7
195
1568
L29
ICPC
Musculoskeletal sympt/complt other
3.0
6.7
31
113
J01FA10
ATC
azithromycin; systemic
2.1
6.7
135
938
SPAT1230
SPAT
Aid fitting and borrowing and monitoring of use
2.4
6.6
54
263
SPAT1254
SPAT
Administration of medicine
2.4
6.6
52
249
M05.8
ICD-10 Finland
Other seropositive rheumatoid arthritis
3.3
6.6
26
86
SPAT1253
SPAT
Initiation, adjustment, discontinuation or repetition of medication
2.1
6.5
83
485
NA1BG
NOMESCO Finland
Cervical spine MRI examination with high intensity magnet
4.3
6.5
17
42
M79.6
ICD-10 Finland
Pain in limb
2.0
6.4
107
690
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
3.2
6.4
27
93
R96
ICPC
Asthma
2.8
6.4
33
128
TNX00
NOMESCO Finland
Puncture and needle biopsy of soft tissue, unspecified region
9.7
6.4
12
13
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
2.8
6.3
34
135
Z71.8
ICD-10 Finland
Other specified counselling
2.1
6.2
78
452
M02AA07
ATC
piroxicam; topical
2.0
6.2
102
653
J01CF05
ATC
flucloxacillin; systemic
3.6
6.2
21
63
R07.3
ICD-10 Finland
Other chest pain
2.7
6.0
34
138
A02BC01
ATC
omeprazole; systemic
2.1
6.0
80
473
J18.9
ICD-10 Finland
Pneumonia, unspecified
2.1
6.0
74
425
XG410
NOMESCO Finland
Flow-volume spirometry
4.2
6.0
16
40
I70.2
ICD-10 Finland
Atherosclerosis of arteries of extremities
2.6
6.0
36
151
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
87
272
4.56
25.91
1.4
1.3
9.64
16.42
u/ml
0.52
25
99
88
293
4.26
23.84
1.5
1.2
33.78
42.04
iu/ml
0.30
30
94
164
869
4.16
22.04
12.7
5.2
24.96
27.14
%
1.56
158
806
162
861
4.05
21.44
12.3
5.0
61.03
57.99
%
2.08
156
800
117
582
3.08
15.63
3.2
2.0
396.58
213.87
u/l
0.32
104
544
173
1075
3.53
15.63
14.1
8.7
4.74
4.17
e9/l
2.20
157
933
156
972
2.92
12.85
7.7
6.1
1.22
1.22
mmol/l
0.48
139
817
195
1386
3.81
12.56
13.2
3.8
14.07
13.23
mm/h
0.31
182
1257
149
928
2.75
11.90
4.8
4.0
0.00
0.00
estimate
-0.00
40
191
95
478
2.69
11.64
2.8
2.7
3666.27
11639.26
umol/l
1.07
85
396
46
154
3.49
11.61
1.7
2.9
66.14
66.47
g/l
0.10
41
136
146
917
2.65
11.19
4.8
3.9
0.00
0.00
estimate
0.50
40
213
146
920
2.63
11.06
6.1
5.2
0.00
0.00
estimate
-0.00
39
196
128
782
2.45
10.00
3.3
2.2
82.86
77.89
nmol/l
1.42
122
679
23
52
4.81
9.79
1.5
1.4
0.01
0.03
iu/ml
—
5
12
139
898
2.40
9.35
6.9
5.5
1.22
1.22
mmol/l
0.28
129
816
20
43
5.00
9.01
1.5
1.3
—
—
—
0
0
193
1477
3.00
8.68
11.9
6.9
76.50
80.01
u/l
0.39
183
1371
27
78
3.79
8.39
1.4
2.4
—
—
—
0
0
88
490
2.30
8.09
2.5
2.0
3.18
3.32
mg/l
0.20
70
415
132
871
2.22
7.96
4.8
3.9
34.82
34.93
g/l
0.07
121
808
61
297
2.44
7.55
3.2
2.9
3.20
2.65
e6/l
0.16
42
155
123
801
2.16
7.53
2.5
2.0
90.84
95.00
pmol/l
0.52
66
385
57
270
2.48
7.48
2.8
2.3
22.20
21.59
%
0.12
52
239
105
647
2.15
7.37
3.2
3.3
1613.47
1719.59
ng/l
0.10
91
549
18
31
6.21
7.08
1.1
1.2
—
—
—
0
0
38
151
2.82
7.05
4.1
3.2
78.02
87.48
ng/l
0.45
33
130
33
122
2.99
6.96
1.5
1.7
—
—
—
0
0
105
674
2.03
6.37
2.7
3.1
2.36
2.35
mmol/l
0.05
90
588
66
366
2.13
5.85
4.8
3.6
74.92
149.56
ng/l
0.57
53
296
16
41
4.12
5.82
1.4
1.4
—
—
—
0
0
141
1025
1.98
5.81
5.4
5.8
9.68
10.94
umol/l
1.86
130
962
95
605
1.98
5.75
2.8
2.3
68.64
61.11
u/l
0.32
86
548
22
72
3.28
5.66
1.9
2.0
33.53
39.53
u/l
0.81
22
62
179
1433
2.16
5.44
5.2
4.0
15.34
14.92
pmol/l
1.23
160
1269
114
791
1.88
5.20
3.4
2.6
112.08
122.56
ug/l
0.29
103
718
60
335
2.07
5.16
1.9
1.8
—
—
—
0
0
16
45
3.75
5.14
1.1
1.1
—
—
—
0
0
132
968
1.86
4.98
16.9
14.9
1.32
1.29
inr
0.11
34
289
17
52
3.45
4.85
1.2
1.3
—
—
—
0
0
103
707
1.83
4.74
4.6
3.1
—
—
—
0
0
148
1136
1.86
4.72
5.9
4.5
6.82
6.74
mmol/l
0.15
142
1055
66
394
1.95
4.67
2.9
2.9
2.47
2.47
mmol/l
0.05
53
347
211
1847
2.91
4.65
30.8
14.9
18.32
23.46
mg/l
2.10
186
1478
84
555
1.81
4.29
4.3
3.1
0.23
0.58
e6/l
1.94
72
421
67
413
1.88
4.27
1.8
1.8
1116.30
1223.03
nmol/l
0.42
55
306
9
13
7.16
4.20
1.3
1.1
—
—
—
0
0
9
13
7.16
4.20
1.3
1.1
—
—
—
0
0
9
13
7.16
4.20
1.3
1.1
—
—
—
0
0
9
13
7.16
4.20
1.3
1.1
—
—
—
0
0
9
13
7.16
4.20
1.3
1.1
—
—
—
0
0
63
389
1.86
3.96
1.4
1.2
1.16
1.80
u/ml
0.41
12
110
51
294
1.95
3.94
3.1
3.1
0.82
0.81
mmol/l
0.22
46
274
54
320
1.90
3.84
3.3
2.7
1.10
1.27
e6/l
0.13
35
176
31
150
2.23
3.79
5.6
5.5
9.60
9.88
mmol/l
0.10
31
140
42
230
2.01
3.75
1.9
1.7
—
—
—
0
0
14
45
3.25
3.72
1.5
1.5
—
—
—
0
0
65
415
1.79
3.64
1.8
1.6
1.46
1.31
mg/l
0.15
52
332
195
1699
2.02
3.51
6.7
4.9
1.65
1.97
mu/l
4.28
179
1518
42
236
1.96
3.48
1.9
1.7
—
—
—
0
0
67
439
1.75
3.41
2.4
2.2
—
—
—
0
0
8
15
5.48
3.22
1.0
1.1
—
—
—
0
0
24
112
2.28
3.20
4.0
3.3
1.71
2.48
mmol/l
0.51
16
87
13
41
3.30
3.11
1.1
1.1
—
—
—
0
0
8
16
5.14
3.08
1.1
1.0
—
—
—
0
0
14
51
2.86
3.04
1.6
1.2
—
—
—
0
0
7
12
5.98
3.04
1.6
1.2
—
—
—
0
0
33
179
1.99
3.02
2.8
2.3
29.35
29.03
u/l
0.03
26
149
28
145
2.06
2.90
1.9
1.5
—
—
—
0
0
139
1131
1.59
2.86
3.2
3.0
42.84
50.20
u/l
0.95
129
1046
10
28
3.69
2.82
1.1
1.0
—
—
—
0
0
15
60
2.61
2.76
1.8
1.5
235.49
275.87
ug/g
—
8
37
5
6
8.48
2.76
1.2
1.3
593.40
1194.33
u/ml
—
5
6
75
533
1.61
2.74
5.3
4.2
0.00
0.00
estimate
-0.00
39
188
111
864
1.55
2.74
3.0
2.4
—
—
—
0
0
98
742
1.56
2.73
4.7
4.1
—
—
—
0
0
70
490
1.62
2.71
2.0
1.5
22.21
21.32
nmol/l
0.19
60
403
6
11
5.57
2.56
1.0
1.0
—
—
—
0
0
124
1001
1.52
2.52
2.9
2.7
—
—
—
0
0
208
1909
2.02
2.40
26.4
17.9
139.76
139.69
mmol/l
0.14
200
1852
208
1914
1.99
2.30
26.8
18.0
3.95
3.98
mmol/l
0.77
199
1854
28
158
1.88
2.30
2.8
2.9
177.86
265.49
ng/l
0.66
23
141
6
13
4.71
2.28
1.0
1.0
—
—
—
0
0
17
80
2.22
2.25
1.9
2.0
—
—
—
0
0
5
9
5.65
2.22
1.0
1.7
—
—
—
0
0
8
24
3.42
2.20
1.1
1.0
—
—
—
0
0
30
176
1.81
2.19
2.2
2.6
7.71
4.89
ug/l
0.44
22
150
11
43
2.64
2.11
1.5
1.3
—
—
—
0
0
11
43
2.64
2.11
1.5
1.3
—
—
—
0
0
9
31
2.98
2.09
9.0
3.3
61.00
61.94
%
—
9
31
5
10
5.08
2.08
1.0
1.1
—
—
—
0
0
5
10
5.08
2.08
1.0
1.2
—
—
—
0
0
8
26
3.15
2.03
1.1
1.3
—
—
—
0
0
191
1731
1.64
2.02
25.3
15.0
75.16
76.20
ml/min/173m2
0.27
171
1417
14
64
2.27
1.99
1.9
5.1
1.24
2.91
ratio
—
5
9
7
21
3.40
1.98
1.0
1.0
—
—
—
0
0
36
231
1.66
1.94
7.9
5.7
2.22
1.46
mmol/l
0.59
28
187
6
17
3.59
1.85
1.7
1.4
—
—
—
0
0
6
17
3.59
1.85
1.7
1.4
—
—
—
0
0
6
17
3.59
1.85
1.0
1.1
—
—
—
0
0
5
12
4.23
1.83
1.0
1.0
—
—
—
0
0
8
29
2.82
1.81
1.6
1.6
—
—
—
0
0
8
29
2.82
1.81
1.6
1.6
—
—
—
0
0
17
89
1.98
1.75
3.3
3.4
24.74
24.41
mmol/l
0.15
17
89
207
1933
1.77
1.72
30.8
18.0
82.42
77.74
umol/l
1.07
207
1933
6
20
3.05
1.59
1.0
1.2
—
—
—
0
0
5
15
3.38
1.53
1.0
1.1
—
—
—
0
0
9
37
2.49
1.49
1.3
1.7
—
—
—
0
0
10
45
2.28
1.48
1.2
1.4
—
—
—
0
0
7
28
2.55
1.46
1.3
1.2
—
—
—
0
0
5
16
3.17
1.44
1.4
1.9
—
—
—
0
0
73
581
1.38
1.41
4.7
3.7
7.23
8.35
mg/mmol
0.17
48
361
206
1940
1.64
1.40
19.5
10.3
25.90
23.77
u/l
0.88
198
1859
98
821
1.34
1.35
5.6
4.1
25.37
42.13
ng/l
1.74
73
596
14
76
1.90
1.33
1.8
1.8
—
—
—
0
0
211
2006
1.70
1.28
40.3
22.3
260.45
246.91
e9/l
1.91
205
1949
211
2008
1.68
1.25
40.1
22.4
39.19
39.42
%
0.21
200
1871
211
2008
1.68
1.25
40.3
22.3
4.35
4.40
e12/l
0.81
204
1946
186
1726
1.42
1.25
7.5
6.1
41.84
40.59
mmol/mol
1.00
170
1586
10
49
2.09
1.24
1.1
1.5
—
—
—
0
0
211
2009
1.67
1.23
40.7
22.4
130.10
132.54
g/l
1.81
206
1967
18
109
1.71
1.23
1.1
1.2
28.50
120.13
iu/ml
—
6
44
5
19
2.67
1.22
1.0
1.2
—
—
—
0
0
191
1787
1.42
1.16
5.8
4.8
5.82
6.02
mmol/l
1.20
175
1603
183
1717
1.33
0.95
4.6
4.1
1.33
1.26
mmol/l
0.75
166
1535
8
42
1.94
0.89
1.4
1.4
27.61
22.43
iu/l
—
8
35
10
57
1.79
0.85
2.1
1.5
—
—
—
0
0
6
31
1.96
0.85
1.8
1.6
—
—
—
0
0
23
165
1.44
0.81
1.5
1.7
1.65
1.43
%
1.42
23
138
8
47
1.73
0.81
1.6
1.5
—
—
—
0
0
0
26
0.00
0.79
0.0
1.2
—
—
—
0
0
34
265
1.33
0.76
1.4
1.4
—
—
—
0
0
5
24
2.11
0.75
1.2
1.7
—
—
—
0
0
5
24
2.11
0.75
1.2
1.7
—
—
—
0
0
5
24
2.11
0.75
1.2
1.7
—
—
—
0
0
188
1788
1.29
0.74
5.1
4.6
4.62
4.62
mmol/l
0.01
176
1623
187
1778
1.29
0.73
5.1
4.6
1.46
1.52
mmol/l
0.96
174
1602
11
68
1.65
0.73
2.2
2.3
—
—
—
0
0
7
116
0.59
0.70
1.4
1.8
—
—
—
0
0
17
119
1.46
0.69
1.6
1.4
—
—
—
0
0
5
27
1.87
0.69
1.6
1.6
—
—
—
0
0
5
28
1.80
0.66
2.0
1.5
—
—
—
0
0
8
50
1.62
0.62
1.6
1.5
—
—
—
0
0
0
21
0.00
0.60
0.0
1.4
—
—
—
0
0
13
89
1.49
0.59
1.1
1.0
—
—
—
0
0
51
434
1.23
0.59
1.6
1.9
442.72
470.93
pmol/l
0.23
43
362
12
82
1.49
0.55
2.5
1.8
1.12
4.74
ug/l
0.50
12
70
9
62
1.47
0.54
1.3
1.2
—
—
—
0
0
9
63
1.45
0.53
1.3
1.2
—
—
—
0
0
53
458
1.20
0.53
4.9
5.5
2.28
2.89
ug/l
0.34
47
398
28
226
1.27
0.51
1.8
4.1
3.73
38.00
ug/l
0.61
20
190
190
1835
1.21
0.47
5.7
5.2
2.70
2.68
mmol/l
0.08
178
1653
8
57
1.42
0.42
1.3
1.5
—
—
—
0
0
19
150
1.29
0.41
4.0
3.0
57.43
63.52
ml/min/173m2
—
7
62
55
488
1.17
0.41
1.5
1.6
1.52
1.32
mmol/l
0.72
48
402
0
15
0.00
0.41
0.0
1.5
—
—
—
0
0
27
228
1.21
0.35
3.0
3.7
—
—
—
0
0
6
43
1.41
0.35
1.2
1.8
—
—
—
0
0
0
11
0.00
0.21
0.0
1.0
—
—
—
0
0
0
12
0.00
0.21
0.0
1.4
—
—
—
0
0
0
12
0.00
0.21
0.0
2.3
—
—
—
0
0
0
12
0.00
0.21
0.0
1.4
—
—
—
0
0
0
13
0.00
0.21
0.0
1.0
—
—
—
0
0
0
13
0.00
0.21
0.0
1.4
—
—
—
0
0
0
14
0.00
0.20
0.0
1.5
—
—
—
0
0
6
50
1.21
0.20
1.5
1.3
—
—
—
0
0
6
50
1.21
0.20
1.5
1.3
—
—
—
0
0
11
90
1.23
0.19
2.3
1.3
—
—
—
0
0
10
117
0.85
0.13
2.7
2.1
—
—
—
0
0
38
360
1.07
0.10
3.2
4.9
17.90
21.58
%
1.22
19
187
28
264
1.07
0.08
3.0
3.2
0.84
0.78
ug/l
0.18
19
175
23
242
0.94
0.05
9.6
7.4
—
—
—
0
0
26
271
0.95
0.04
1.5
1.4
—
—
—
0
0
11
108
1.02
0.00
1.8
2.4
1.25
1.11
%
0.20
11
108
11
107
1.03
0.00
2.5
2.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
7.80
—
0
5
0
7
0.00
-0.00
0.0
1.4
—
—
—
0
0
6
61
0.98
-0.00
2.0
1.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
9
0.00
-0.00
0.0
2.1
—
13.67
—
0
9
0
9
0.00
-0.00
0.0
2.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint M13_MULTIFIBRO and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_MULTIFIBRO | 1.619 [1.38, 1.9] | < 0.001 |
| Birth year | 0.99 [0.98, 1.0] | 0.019 |
During the follow-up period (1.1.1998 — 31.12.2019), 528 out of 1187 females with M13_MULTIFIBRO died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_MULTIFIBRO | 1.371 [1.09, 1.72] | 0.006 |
| Birth year | 0.988 [0.98, 1.0] | 0.015 |
During the follow-up period (1.1.1998 — 31.12.2019), 229 out of 481 males with M13_MULTIFIBRO died.
Mortality risk
Mortality risk for people of age
years, who have M13_MULTIFIBRO.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.105% | 0.27% |
| 5 | 0.745% | 1.63% |
| 10 | 1.866% | 3.975% |
| 15 | 3.45% | 7.504% |
| 20 | 6.278% | 13.11% |
Relationships between endpoints
↥Index endpoint: M13_MULTIFIBRO – Multifocal fibrosclerosis
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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