Recurrent and persistent haematuria

N14_RECURANDPERHEAMATUR

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 N02#
  • Cause of death: ICD-10 N02#

2 out of 7 registries used, show all original rules.

299

4. Check minimum number of events

None

299

5. Include endpoints

None

299

6. Filter based on genotype QC (FinnGen only)

299

Control definitions (FinnGen only)

Control exclude
N14_GLOMERULAR

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
N00-N08
Name in latin
Haematuria recidiva et persistens

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 2501 1150 1325
Only index persons 2128 1044 1084
Unadjusted period prevalence (%)
Whole population 0.04 0.03 0.04
Only index persons 0.04 0.04 0.04
Median age at first event (years)
Whole population 52.05 43.41 59.18
Only index persons 48.62 41.87 55.11

-FinnGen-

Key figures

All Female Male
Number of individuals 299 140 159
Unadjusted period prevalence (%) 0.06 0.05 0.07
Median age at first event (years) 51.75 43.14 59.34

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
274
Matched controls
2739
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
N02.9
ICD-10 Finland
Recurrent and persistent haematuria, unspecified
+∞
152.8
132
*
R31
ICD-10 Finland
Unspecified haematuria
14.4
65.0
122
144
N08.2*D89.80
ICD-10 Finland
Immunoglobulin A (IgA) nephropathy
+∞
47.3
44
*
N02
ICD-10 Finland
Recurrent and persistent haematuria
+∞
31.9
30
*
UKC02
NOMESCO Finland
Cystoscopy
5.8
30.6
103
259
N02.0
ICD-10 Finland
Recurrent and persistent haematuria, minor glomerular abnormality
+∞
29.7
28
*
N02.8
ICD-10 Finland
Recurrent and persistent haematuria, other
+∞
29.7
28
*
123
Kela drug reimbursment
Chronic disorders of vitamin D metabolism
29.9
24.2
32
12
N08.2
ICD-10 Finland
Glomerular disorders in blood diseases and disorders involving the immune mechanism
+∞
22.2
21
*
KA3AT
NOMESCO Finland
Biopsy of kidney with ultrasound guidance
87.4
22.0
24
*
138
Kela drug reimbursment
Severe anaemia associated with chronic renal failure
29.3
21.8
29
11
A11CC03
ATC
alfacalcidol; systemic
23.9
21.3
30
14
D89.80
ICD-10 Finland
Immunoglobulin A (IgA) deposits in organisms
+∞
21.1
20
*
KA1AE
NOMESCO Finland
Kidney ultrasound examination
18.9
21.1
32
19
I15.1
ICD-10 Finland
Hypertension secondary to other renal disorders
52.4
20.5
24
5
N18.8
ICD-10 Finland
Other chronic renal failure
21.4
20.0
29
15
B03XA01
ATC
erythropoietin; parenteral
71.5
18.0
20
*
N03.9
ICD-10 Finland
Chronic nephritic syndrome, unspecified
+∞
17.9
17
*
A12AA04
ATC
calcium carbonate; oral
45.3
17.5
21
5
N02.2
ICD-10 Finland
Recurrent and persistent haematuria, diffuse membranous glomerulonephritis
+∞
15.8
15
*
N02.1
ICD-10 Finland
Recurrent and persistent haematuria, focal and segmental glomerular lesions
+∞
15.8
15
*
N18.9
ICD-10 Finland
Chronic kidney disease, unspecified
6.9
15.7
40
66
KH1AE
NOMESCO Finland
Urinary tract ultrasound examination
7.7
15.3
36
53
Z94.0
ICD-10 Finland
Kidney transplant status
33.8
15.0
19
6
KAS10
NOMESCO Finland
Allogenic transplantation of kidney from cadaver donor
60.1
15.0
17
*
N02.3
ICD-10 Finland
Recurrent and persistent haematuria, diffuse mesangial proliferative glomerulonephritis
+∞
14.7
14
*
KA2AE
NOMESCO Finland
Ultrasound examination transplanted kidney
158.0
14.6
15
*
L04AA06
ATC
mycophenolic acid; systemic
20.5
14.5
21
11
137
Kela drug reimbursment
Uraemia requiring dialysis
79.2
13.7
15
*
Z49.1
ICD-10 Finland
Extracorporeal dialysis
22.5
12.2
17
8
R80
ICD-10 Finland
Isolated proteinuria
22.5
12.2
17
8
B03XA02
ATC
darbepoetin alfa; parenteral
21.1
11.3
16
8
L04AD01
ATC
ciclosporin; systemic
21.1
11.3
16
8
127
Kela drug reimbursment
Transplant complication
18.8
10.9
16
9
N18.0
ICD-10 Finland
End-stage renal disease
29.4
10.8
14
5
N02.4
ICD-10 Finland
Recurrent and persistent haematuria, diffuse endocapillary proliferative glomerulonephritis
+∞
10.5
10
*
N02BE
ICD-10 Finland
NA
+∞
10.5
10
*
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
3.5
10.4
52
174
PBL10
NOMESCO Finland
Construction of arteriovenous fistula from radial artery
41.7
10.0
12
*
B05DB
ATC
Hypertonic solutions
57.0
9.7
11
*
B05DA
ATC
Isotonic solutions
57.0
9.7
11
*
KA2AT
NOMESCO Finland
Biopsy of transplanted kidney with ultrasound guidance
103.4
9.5
10
*
TK800
NOMESCO Finland
Hemodialysis
11.2
9.4
17
16
J01MA02
ATC
ciprofloxacin; systemic
2.3
9.4
124
729
Z49.2
ICD-10 Finland
Other dialysis
38.0
9.1
11
*
C03CA01
ATC
furosemide; systemic
2.4
9.0
94
490
N39.0
ICD-10 Finland
Urinary tract infection, site not specified
3.2
8.8
49
176
N39.1
ICD-10 Finland
Persistent proteinuria, unspecified
51.7
8.7
10
*
J01EE01
ATC
sulfamethoxazole and trimethoprim; systemic
4.8
8.7
28
63
205
Kela drug reimbursment
Chronic hypertension
2.4
8.6
86
436
V03AE01
ATC
polystyrene sulfonate; oral
20.8
8.5
12
6
N03.3
ICD-10 Finland
Chronic nephritic syndrome, diffuse mesangial proliferative glomerulonephritis
+∞
8.4
8
*
190
Kela drug reimbursment
Lanthanum carbonate, sevelamer and sucroferric oxyhydroxide
34.4
8.1
10
*
L04AA01
ATC
[U] ciclosporin; systemic
13.6
8.0
13
10
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
2.2
7.4
88
482
C09AA02
ATC
enalapril; systemic
2.5
7.4
65
308
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
2.9
7.3
45
174
L04AD02
ATC
tacrolimus; systemic (calcineurin inhibitors)
30.9
7.2
9
*
KH1BT
NOMESCO Finland
Urinary tract cathetrisation with X-ray guidance
20.7
7.2
10
5
C08CA01
ATC
amlodipine; oral
2.1
7.1
102
604
N13.3
ICD-10 Finland
Other and unspecified hydronephrosis
8.6
6.9
14
17
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
4.2
6.9
25
64
UKB02
NOMESCO Finland
Retrograde ureteroscopy
17.2
6.8
10
6
R60.0
ICD-10 Finland
Localized oedema
3.1
6.7
35
122
J18.9
ICD-10 Finland
Pneumonia, unspecified
2.2
6.5
77
417
R33
ICD-10 Finland
Retention of urine
3.3
6.5
32
107
K65.0
ICD-10 Finland
Acute peritonitis
14.8
6.4
10
7
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.0
6.4
116
748
R50.9
ICD-10 Finland
Fever, unspecified
2.5
6.4
50
222
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
2.0
6.4
102
627
N30.0
ICD-10 Finland
Acute cystitis
2.7
6.3
44
183
J01DB01
ATC
cefalexin; oral
2.1
6.3
221
1811
M05BA04
ATC
alendronic acid; oral
3.4
6.3
29
92
N08.39*E10.2
ICD-10 Finland
Insulin-dependent diabetes mellitus - Diabetic nephropathy
+∞
6.3
6
*
N03.2
ICD-10 Finland
Chronic nephritic syndrome, diffuse membranous glomerulonephritis
+∞
6.3
6
*
N04.2
ICD-10 Finland
Nephrotic syndrome, diffuse membranous glomerulonephritis
+∞
6.3
6
*
A02BC02
ATC
pantoprazole; systemic
1.9
6.2
170
1265
C09CA01
ATC
losartan; oral
2.2
6.0
67
353
N02BE01
ATC
paracetamol; systemic, rectal
2.1
6.0
224
1859

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
46
93
5.66
22.41
3.2
2.6
—
—
—
0
0
176
913
3.26
22.21
11.4
4.4
34.4
35.7
g/l
2.08
168
861
65
189
4.12
20.30
12.4
3.1
1.5
2.0
mmol/l
0.46
54
139
66
196
4.04
20.00
12.5
3.3
—
—
—
0
0
82
286
3.57
19.63
5.4
2.0
23.0
23.4
%
0.08
72
248
41
84
5.50
19.62
12.9
3.0
23.5
24.1
mmol/l
0.63
35
76
112
475
3.17
19.48
8.1
2.4
4.2
6.2
e6/l
0.54
101
414
60
171
4.14
19.20
13.7
6.8
—
—
—
0
0
130
606
3.03
19.08
9.4
3.7
33.0
10.0
mg/mmol
2.69
108
385
124
567
3.03
18.78
7.8
3.1
616.3
169.8
mg/l
0.56
103
369
182
1057
2.84
17.17
17.1
6.3
1.2
1.2
mmol/l
0.15
161
894
135
687
2.76
16.25
9.9
3.1
104.9
156.4
e6/l
0.22
110
530
103
455
2.93
16.23
7.2
2.6
554.8
558.4
mosm/kgh2o
0.06
93
381
169
967
2.72
16.06
14.3
5.6
1.2
1.2
mmol/l
0.09
157
873
127
632
2.75
15.90
7.7
2.9
7.6
8.0
mmol/l
0.41
112
532
149
806
2.69
15.77
10.7
3.6
74.3
66.0
e6/l
0.09
118
573
118
579
2.71
15.03
3.9
2.6
3308.4
7723.9
umol/l
0.61
111
505
127
652
2.65
14.71
12.1
3.5
7.4
7.4
ph
0.26
25
119
183
1129
2.60
14.32
7.9
3.4
0.0
0.0
estimate
0.00
33
220
227
1562
2.88
14.13
10.1
4.0
—
—
—
0
0
185
1156
2.57
13.95
7.9
3.4
0.0
0.0
estimate
0.00
33
207
120
614
2.59
13.82
7.3
4.6
—
—
—
0
0
132
718
2.50
13.24
5.5
3.1
2.3
2.3
mmol/l
1.87
120
630
181
1137
2.50
13.23
10.6
4.7
0.0
0.0
estimate
0.50
33
221
26
50
5.60
13.21
2.0
1.3
—
—
—
0
0
118
618
2.50
12.74
8.8
3.0
0.3
0.4
e6/l
0.64
93
460
118
633
2.43
11.95
4.5
2.9
—
—
—
0
0
115
612
2.43
11.83
8.1
2.9
—
—
—
0
0
22
40
5.86
11.83
1.8
3.8
—
—
—
0
0
213
1484
2.51
11.80
10.4
4.2
183.3
275.5
e6/l
—
10
27
104
532
2.46
11.64
2.4
2.0
2.8
3.0
mg/l
0.57
93
450
133
762
2.34
11.50
9.8
5.4
—
—
—
0
0
73
321
2.69
11.14
2.9
2.2
—
—
—
0
0
60
238
2.90
11.13
7.3
8.8
0.8
1.2
mmol/l
0.21
44
189
27
63
4.61
11.01
3.6
4.0
0.7
0.1
g/l
0.90
12
25
32
88
3.95
10.57
1.4
1.2
—
—
—
0
0
26
61
4.57
10.53
1.9
3.3
47.2
149.1
mg/l
0.51
18
51
26
61
4.57
10.53
1.9
3.3
35.0
31.2
mg/l
0.22
18
51
160
1018
2.23
10.47
4.7
2.5
141.2
117.7
ug/l
0.78
148
939
54
211
2.90
10.25
7.3
9.4
94.7
95.7
%
0.56
48
202
18
31
6.11
10.19
2.1
2.6
—
—
—
0
0
17
28
6.38
10.04
1.1
1.3
—
—
—
0
0
41
138
3.28
10.03
4.2
3.1
7.4
7.4
ph
—
8
15
22
48
4.87
9.70
1.7
1.3
—
—
—
0
0
17
31
5.75
9.08
7.3
2.1
—
—
—
0
0
94
509
2.24
8.88
6.8
3.4
—
—
—
0
0
55
236
2.63
8.68
8.0
8.8
11.3
12.1
kpa
0.52
50
227
55
236
2.63
8.68
7.9
8.8
4.9
5.0
kpa
0.28
50
225
173
1190
2.08
8.66
11.0
5.7
2.3
1.9
e9/l
0.43
157
1064
19
41
4.88
8.47
2.7
2.0
—
—
—
0
0
135
857
2.05
8.33
10.1
8.4
1.1
1.2
inr
1.33
43
275
172
1194
2.04
8.24
11.7
6.1
0.2
0.2
e9/l
0.17
159
1064
117
710
2.06
8.12
3.1
2.3
—
—
—
0
0
60
277
2.46
8.11
10.1
6.6
103.8
104.3
mmol/l
0.38
55
272
167
1155
2.01
8.00
11.2
5.7
0.6
0.6
e9/l
0.98
151
1011
167
1158
2.00
7.91
11.2
5.7
0.0
0.0
e9/l
0.43
152
1019
185
1337
2.01
7.70
16.1
9.5
4.4
4.1
e9/l
0.98
173
1179
16
33
5.07
7.49
6.1
3.2
—
—
—
0
0
224
1747
2.13
7.38
13.4
7.1
76.4
76.8
u/l
0.04
217
1628
12
19
6.54
7.30
1.3
3.0
—
—
—
0
0
34
125
2.94
7.14
7.7
5.1
23.9
24.7
mmol/l
0.60
34
125
30
105
3.06
6.86
10.1
13.9
—
—
—
0
0
62
314
2.23
6.72
1.3
1.3
270.8
428.8
titre
1.70
13
64
19
50
3.99
6.64
5.2
1.8
—
—
—
0
0
55
266
2.31
6.64
2.2
1.7
—
—
—
0
0
40
172
2.53
6.23
2.9
2.3
69.7
68.3
e9/l
0.11
31
129
85
502
1.97
6.09
8.4
3.6
1.0
1.0
kg/l
0.51
16
72
177
1321
1.83
6.04
9.5
4.7
6.5
6.7
mmol/l
0.60
172
1224
69
385
2.03
5.77
2.0
1.6
1399.1
1201.7
nmol/l
0.71
54
288
102
656
1.84
5.57
7.5
3.0
—
—
—
0
0
55
286
2.13
5.53
2.9
1.5
—
—
—
0
0
125
857
1.79
5.52
2.3
1.9
90.9
94.1
pmol/l
0.40
70
446
8
5
16.37
5.44
1.0
1.0
—
—
—
0
0
97
620
1.84
5.38
9.0
3.7
0.0
0.0
estimate
0.40
29
213
33
139
2.54
5.36
1.8
2.4
—
—
—
0
0
12
26
4.77
5.30
1.0
1.2
—
—
—
0
0
266
2314
2.35
5.30
33.3
13.6
21.3
23.5
mg/l
0.64
244
1819
156
1151
1.74
5.26
7.7
6.2
12.9
11.3
umol/l
0.39
156
1090
146
1059
1.74
5.22
5.9
4.1
—
—
—
0
0
34
148
2.46
5.16
4.9
2.4
—
—
—
0
0
84
519
1.86
5.16
1.7
1.5
16.5
20.8
nmol/l
2.77
79
444
27
106
2.70
5.04
6.6
3.6
—
—
—
0
0
30
131
2.43
4.53
6.9
7.8
—
—
—
0
0
98
662
1.71
4.36
2.7
2.2
133.8
348.8
u/l
1.21
93
636
37
181
2.19
4.32
1.7
1.5
—
—
—
0
0
64
388
1.83
4.10
6.6
3.3
4167.4
206.2
ng/l
0.48
47
292
78
503
1.75
4.06
2.6
1.8
—
—
—
0
0
11
28
4.04
4.01
7.4
1.6
73.7
61.9
%
1.02
11
28
9
14
6.59
4.01
2.0
1.8
—
—
—
0
0
15
49
3.17
3.86
1.3
1.2
—
—
—
0
0
69
437
1.75
3.81
2.0
1.7
400.2
439.7
pmol/l
0.56
61
380
85
571
1.68
3.79
14.0
7.0
—
—
—
0
0
263
2350
1.99
3.74
39.0
15.2
4.0
4.0
mmol/l
3.01
258
2278
80
534
1.68
3.64
1.9
1.7
0.8
1.3
mg/l
1.75
62
413
64
402
1.75
3.63
2.7
1.6
—
—
—
0
0
262
2345
1.95
3.61
38.3
15.1
139.6
139.7
mmol/l
0.22
257
2274
16
57
2.91
3.58
5.0
3.1
—
—
—
0
0
8
13
6.29
3.52
4.4
2.0
11.9
10.9
%
—
8
13
21
88
2.49
3.48
2.0
1.7
—
—
—
0
0
63
402
1.72
3.37
4.8
3.0
2.5
2.4
mmol/l
0.63
52
357
116
867
1.55
3.27
4.9
3.8
48.7
45.1
ng/l
0.10
86
599
23
104
2.31
3.25
4.2
3.3
—
—
—
0
0
27
132
2.15
3.18
1.3
1.2
—
—
—
0
0
9
20
4.60
3.14
2.1
2.0
—
—
—
0
0
204
1737
1.55
3.07
5.6
3.7
15.6
11.2
mm/h
2.66
194
1597
32
170
1.99
3.04
8.5
3.4
—
—
—
0
0
11
35
3.22
2.96
1.0
1.5
0.6
0.6
g/l
—
5
30
8
17
4.80
2.94
1.3
1.1
—
—
—
0
0
9
22
4.18
2.90
6.0
3.5
—
—
—
0
0
201
1720
1.51
2.84
4.0
3.8
14.6
14.7
pmol/l
0.22
183
1568
131
1036
1.47
2.70
18.8
9.4
0.0
0.0
e9/l
0.48
109
856
7
15
4.75
2.61
7.3
3.5
—
—
—
0
0
21
101
2.16
2.60
2.6
2.3
—
—
—
0
0
9
25
3.68
2.59
2.2
2.1
32.1
33.2
pg
—
9
25
12
44
2.80
2.58
2.6
2.0
—
—
—
0
0
46
291
1.69
2.53
1.3
1.3
—
—
—
0
0
44
275
1.70
2.53
29.4
24.3
1.0
1.4
inr
—
7
34
5
8
6.33
2.38
5.4
3.8
49.0
58.1
%
—
5
8
7
18
3.95
2.26
2.3
1.6
—
—
—
0
0
5
9
5.63
2.22
4.0
1.3
—
—
—
0
0
7
20
3.56
2.06
1.0
1.3
—
—
—
0
0
32
194
1.73
2.06
11.8
3.2
—
—
—
0
0
8
26
3.13
2.03
1.4
2.6
—
—
—
0
0
112
902
1.39
1.95
2.2
2.0
—
—
—
0
0
11
46
2.44
1.87
1.3
1.3
—
—
—
0
0
10
40
2.55
1.85
1.2
1.3
—
—
—
0
0
28
169
1.72
1.85
4.6
5.2
0.0
0.2
%
—
9
51
12
53
2.32
1.83
6.0
2.1
2.4
2.4
mmol/l
—
5
35
12
53
2.32
1.83
6.0
2.1
4.9
5.0
kpa
0.29
12
53
12
53
2.32
1.83
6.0
2.1
8.8
8.6
kpa
0.13
12
53
9
35
2.62
1.81
2.0
2.8
—
—
—
0
0
7
23
3.09
1.81
1.1
1.0
—
—
—
0
0
83
643
1.40
1.80
4.1
3.7
—
—
—
0
0
54
387
1.48
1.77
1.1
1.3
18.0
9.1
u/ml
0.21
19
158
241
2218
1.45
1.75
4.5
3.8
1.4
1.3
mmol/l
0.96
226
2036
251
2328
1.49
1.74
5.4
4.5
2.6
2.8
mmol/l
1.82
239
2147
14
68
2.11
1.73
4.8
4.1
—
—
—
0
0
43
295
1.53
1.73
2.7
2.3
126.8
142.5
ug/g
0.13
33
231
6
19
3.20
1.67
1.0
1.5
—
—
—
0
0
67
513
1.39
1.55
1.2
1.3
0.5
1.6
u/ml
1.74
14
136
30
195
1.60
1.53
1.6
1.4
—
—
—
0
0
7
27
2.63
1.52
1.3
1.3
—
—
—
0
0
81
643
1.36
1.50
1.6
1.5
—
—
—
0
0
30
198
1.57
1.44
9.0
3.9
—
—
—
0
0
27
174
1.61
1.43
3.7
4.7
1.1
0.4
%
—
7
44
238
2212
1.37
1.40
5.0
4.2
5.8
5.9
mmol/l
0.24
224
2033
245
2288
1.39
1.40
5.1
4.2
4.4
4.6
mmol/l
2.20
234
2122
244
2279
1.38
1.37
5.0
4.1
1.4
1.4
mmol/l
2.88
232
2104
177
1581
1.29
1.37
4.1
3.6
—
—
—
0
0
225
2080
1.33
1.32
7.2
5.3
39.4
39.6
mmol/mol
0.10
215
1945
53
401
1.39
1.32
1.2
1.3
81.0
35.1
iu/ml
0.37
13
125
62
483
1.36
1.29
1.5
1.3
2.5
2.5
g/l
0.00
41
301
8
35
2.32
1.28
3.8
3.1
3.9
4.5
e9/l
—
8
35
69
548
1.34
1.27
7.1
4.8
—
—
—
0
0
8
36
2.26
1.25
3.9
3.2
59.9
59.2
%
—
8
36
8
37
2.19
1.22
1.1
1.4
—
—
—
0
0
6
26
2.33
1.19
2.3
1.3
92.5
89.2
%
—
6
26
28
193
1.50
1.14
5.0
4.8
1.5
0.8
%
0.27
11
64
35
253
1.43
1.13
1.7
1.3
—
—
—
0
0
39
288
1.41
1.12
3.0
2.7
11.8
8.3
umol/l
0.32
33
246
13
74
1.79
1.08
1.9
1.2
—
—
—
0
0
257
2448
1.35
1.03
29.7
12.4
—
—
—
0
0
15
91
1.68
1.02
1.1
1.2
—
—
—
0
0
223
2086
1.27
1.02
5.2
4.5
1.8
1.9
mu/l
0.71
208
1903
26
181
1.48
1.02
5.2
5.0
0.4
0.2
%
0.32
11
59
33
242
1.41
1.00
1.3
1.4
—
—
—
0
0
5
23
2.19
0.98
1.0
1.2
—
—
nmol/l
—
0
0
229
2155
1.27
0.96
33.3
14.1
38.4
40.2
%
2.04
174
1641
6
28
2.17
0.92
1.0
1.2
—
—
nmol/l
—
0
0
6
29
2.09
0.90
1.0
1.4
—
—
—
0
0
6
29
2.09
0.90
1.0
1.4
—
—
—
0
0
6
29
2.09
0.90
1.0
1.4
—
—
—
0
0
6
29
2.09
0.90
1.0
1.4
—
—
—
0
0
6
29
2.09
0.90
4.8
3.2
—
—
—
0
0
8
45
1.80
0.85
1.0
1.1
—
—
—
0
0
8
45
1.80
0.85
1.0
1.1
—
—
—
0
0
69
582
1.24
0.81
1.8
1.6
1.4
1.4
mmol/l
0.01
61
490
5
25
2.02
0.73
1.0
1.2
—
—
—
0
0
19
135
1.44
0.71
3.3
3.5
4.5
4.6
pmol/l
0.17
19
118
5
26
1.94
0.71
2.0
2.3
—
—
—
0
0
34
267
1.31
0.71
2.0
1.5
—
—
—
0
0
95
839
1.19
0.71
5.4
5.0
4.1
2.8
ug/l
0.58
84
759
5
27
1.87
0.68
1.0
1.5
28.4
16.5
ug/l
—
5
27
19
259
0.72
0.68
1.4
1.3
—
—
—
0
0
12
78
1.56
0.66
1.6
1.6
—
—
—
0
0
5
28
1.80
0.66
12.2
17.4
1838.0
1501.9
nmol/l
—
5
28
36
288
1.28
0.66
1.1
1.3
—
—
—
0
0
0
21
0.00
0.60
0.0
1.2
—
—
—
0
0
12
171
0.69
0.56
1.2
1.5
—
—
—
0
0
32
260
1.26
0.54
1.6
1.5
—
—
—
0
0
12
83
1.46
0.52
8.5
4.7
—
—
—
0
0
18
136
1.34
0.50
1.9
1.8
—
—
—
0
0
20
154
1.32
0.50
1.4
1.3
—
—
—
0
0
12
85
1.43
0.47
28.2
9.4
—
—
—
0
0
8
56
1.44
0.43
1.5
1.3
—
—
—
0
0
15
114
1.33
0.41
1.0
1.1
—
6.2
—
0
5
0
15
0.00
0.41
0.0
1.7
—
21.2
—
0
15
0
15
0.00
0.41
0.0
2.1
—
—
—
0
0
11
80
1.39
0.39
1.4
1.2
—
—
—
0
0
32
274
1.19
0.35
2.2
1.7
—
—
—
0
0
19
156
1.23
0.32
1.2
1.3
—
32.6
—
0
11
8
66
1.22
0.27
3.0
1.9
—
—
—
0
0
5
38
1.32
0.23
1.8
2.3
2.7
5.0
umol/l
—
5
27
20
172
1.17
0.22
2.0
2.4
—
12.5
—
0
9
0
10
0.00
0.21
0.0
1.4
—
—
—
0
0
85
897
0.93
0.21
3.7
2.6
—
—
—
0
0
25
221
1.14
0.21
2.8
4.1
3.4
9.9
ug/l
1.78
20
181
0
13
0.00
0.21
0.0
1.3
—
—
—
0
0
0
14
0.00
0.20
0.0
1.0
—
264.6
—
0
8
0
14
0.00
0.20
0.0
1.2
—
217.7
—
0
14
7
61
1.15
0.17
1.7
1.5
—
—
—
0
0
7
61
1.15
0.17
1.7
1.5
—
—
—
0
0
10
84
1.20
0.14
2.9
1.5
—
—
—
0
0
12
105
1.15
0.11
2.7
1.5
—
—
—
0
0
19
175
1.09
0.08
1.3
1.1
—
—
—
0
0
12
107
1.13
0.08
2.7
1.5
—
—
—
0
0
12
107
1.13
0.08
2.7
1.5
—
—
—
0
0
12
107
1.13
0.08
2.7
1.5
—
—
—
0
0
6
57
1.05
0.08
1.0
1.2
—
—
—
0
0
53
510
1.05
0.08
3.6
3.1
1.6
0.8
ug/l
0.47
39
338
7
65
1.08
0.08
1.7
1.6
—
—
—
0
0
14
128
1.10
0.07
1.2
1.2
—
—
—
0
0
18
170
1.06
0.04
1.2
1.2
177.2
148.8
iu/ml
—
10
66
11
102
1.08
0.03
2.7
1.5
—
—
—
0
0
12
113
1.06
0.02
1.0
1.1
—
—
—
0
0
11
113
0.97
0.00
1.1
1.1
—
—
—
0
0
26
263
0.99
0.00
2.1
1.7
—
—
—
0
0
0
9
0.00
0.00
0.0
1.3
—
—
—
0
0
0
9
0.00
0.00
0.0
3.0
—
—
—
0
0
0
9
0.00
0.00
0.0
2.4
—
—
—
0
0
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
2.9
—
—
—
0
0
0
8
0.00
0.00
0.0
1.5
—
—
—
0
0
0
5
0.00
0.00
0.0
3.2
—
—
—
0
0
0
8
0.00
0.00
0.0
1.4
—
—
—
0
0
6
62
0.97
0.00
1.0
1.1
—
—
—
0
0
0
6
0.00
0.00
0.0
5.8
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
0
7
0.00
0.00
0.0
2.4
—
10405.6
—
0
7
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
2.0
—
0
5
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
2.8
—
1.1
—
0
5

Mortality – FinRegistry

Association

Association between endpoint N14_RECURANDPERHEAMATUR and mortality.

Females

Parameter HR [95% CI] p-value
N14_RECURANDPERHEAMATUR 2.32 [1.83, 2.94] < 0.001
Birth year 0.992 [0.98, 1.0] 0.11

During the follow-up period (1.1.1998 — 31.12.2019), 187 out of 1005 females with N14_RECURANDPERHEAMATUR died.

Males

Parameter HR [95% CI] p-value
N14_RECURANDPERHEAMATUR 2.256 [1.73, 2.94] < 0.001
Birth year 0.985 [0.98, 0.99] 0.002

During the follow-up period (1.1.1998 — 31.12.2019), 422 out of 1118 males with N14_RECURANDPERHEAMATUR died.

Mortality risk

Mortality risk for people of age

years, who have N14_RECURANDPERHEAMATUR.

N-year risk Females Males
1 0.215% 0.347%
5 1.295% 2.358%
10 3.217% 5.811%
15 5.868% 11.113%
20 10.82% 18.533%

Relationships between endpoints

Index endpoint: N14_RECURANDPERHEAMATUR – Recurrent and persistent haematuria

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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