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Osteonecrosis due to drugs

EFO Endpoint Browser PheWeb

OSTEON_DRUGS

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

519972

1. Apply sex-specific rule

None

519972

2. Check conditions

None

519972

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — M87.1#

1 out of 7 registries used, show all original rules.

496

4. Check minimum number of events

None

496

5. Include endpoints

None

496

6. Filter based on genotype QC (FinnGen only)

469

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy
C
First used in FinnGen datafreeze
DF5

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 1822 909 908
Only index persons 1748 891 857
Unadjusted period prevalence (%)
Whole population 0.03 0.03 0.03
Only index persons 0.03 0.03 0.03
Median age at first event (years)
Whole population 67.96 67.79 68.14
Only index persons 68.30 68.00 68.61

-FinnGen-

Key figures

All Female Male
Number of individuals 469 237 232
Unadjusted period prevalence (%) 0.10 0.08 0.11
Median age at first event (years) 70.57 69.48 71.69

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
496
Matched controls
4960
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
M05BX04
ATC
denosumab; parenteral
47.5
307.7
307
164
M87.1
ICD-10 Finland
Osteonecrosis due to drugs
+∞
307.7
496
*
C79.5
ICD-10 Finland
Secondary malignant neoplasm of bone and bone marrow
50.8
256.6
155
44
ECB20
NOMESCO Finland
Oral alveoplasty
88.8
254.9
136
21
EB1BI
NOMESCO Finland
Cone beam imaging of teeth and jaws (1–2 quarters)
65.5
199.9
112
22
WF049
NOMESCO Finland
Radiotherapy of metastasis
23.8
187.5
148
87
WD105
NOMESCO Finland
Cystostatic therapy of methastized malignancy
21.2
187.0
158
107
H02AB02
ATC
dexamethasone; systemic
12.2
175.2
249
378
WD305
NOMESCO Finland
Simple therapy of methastized malignancy with biomodifiers
46.7
162.7
98
26
163
Kela drug reimbursment
Abiraterone and enzalutamide
63.6
158.7
89
17
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
14.3
149.7
415
1308
N02AA05
ATC
oxycodone; systemic
8.7
131.8
278
637
WD205
NOMESCO Finland
Therapy of methastized malignancy with hormones
57.8
129.9
74
15
L02BX03
ATC
abiraterone; oral
61.5
122.7
69
13
352
Kela drug reimbursment
Abiraterone and enzalutamide
65.5
122.4
68
12
L02BB04
ATC
enzalutamide; oral
54.2
121.3
70
15
C79.8
ICD-10 Finland
Secondary malignant neoplasm of other specified sites
14.8
117.9
116
100
SAA03
NOMESCO Finland
Extended examination of mouth
9.1
115.8
381
1321
WD225
NOMESCO Finland
Demanding therapy of methastized malignancy with hormones
48.3
113.2
67
16
L02BA03
ATC
fulvestrant; parenteral
61.9
106.9
60
11
A03FA01
ATC
metoclopramide; systemic, rectal
7.1
106.8
281
773
WZC00
NOMESCO Finland
Treatment plan or consultation
7.1
97.1
353
1279
Z51.5
ICD-10 Finland
Palliative care
8.3
94.1
151
248
ZX112
NOMESCO Finland
Subcutaneous
15.8
93.6
86
65
NK6AN
NOMESCO Finland
Total body bone isotope imaging
14.7
87.7
84
68
A04AA02
ATC
granisetron; systemic, transdermal
8.5
84.7
128
195
1501
Kela drug reimbursment
Palbociclib
53.0
83.0
48
10
116
Kela drug reimbursment
Prostate cancer
8.8
82.6
119
171
A04AA01
ATC
ondansetron; systemic, rectal
7.6
81.9
140
244
L02BX02
ATC
degarelix; parenteral
28.6
81.5
56
22
JN4AD
NOMESCO Finland
Body CT examination
6.7
80.3
161
330
153
Kela drug reimbursment
Lenalidomid
41.7
80.1
49
13
Y77
ICPC
Malignant neoplasm prostate
12.0
79.0
86
85
L04AX04
ATC
lenalidomide; oral
40.8
78.0
48
13
C90.0
ICD-10 Finland
Multiple myeloma
24.6
73.0
53
24
A79
ICPC
Malignancy NOS
20.6
72.7
57
31
L03AA02
ATC
filgrastim; parenteral
11.7
72.7
80
80
L02BB03
ATC
bicalutamide; oral
13.0
72.5
74
66
ZX120
NOMESCO Finland
Intravenous
6.6
71.8
140
277
EB1CI
NOMESCO Finland
Cone beam imaging of teeth and jaws (3-4 quarters)
32.3
71.5
47
16
EB1AI
NOMESCO Finland
Cone beam imaging of teeth and jaws (one quarter)
21.5
70.3
54
28
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
5.2
67.1
344
1509
JN4BD
NOMESCO Finland
Extensive body CT
5.7
66.1
156
367
A49.9
ICD-10 Finland
Bacterial infection, unspecified
5.7
65.6
155
365
WD505
NOMESCO Finland
Simple enzyme inhibitor or similar therapy of methastized malignancy
25.2
64.2
46
20
L02BG06
ATC
exemestane; oral
14.8
62.4
58
44
L02AE02
ATC
leuprorelin; implant, parenteral
8.2
61.4
90
130
N02AB03
ATC
fentanyl; nasal, sublingual, transdermal
8.6
59.9
84
115
R50.9
ICD-10 Finland
Fever, unspecified
5.0
57.4
164
449
X76
ICPC
Malignant neoplasm breast female
12.5
53.6
55
49
WW500
NOMESCO Finland
Blood transfusion
7.9
51.5
77
113
8140/3-C61.9
ICD-O-3
Adenocarcinoma, NOS, of prostate gland
5.3
51.4
126
301
XW000
NOMESCO Finland
Bone marrow biopsy
7.6
50.9
79
121
WF004
NOMESCO Finland
Palliative radiotherapy
12.5
49.9
51
45
L03AA13
ATC
pegfilgrastim; parenteral
7.3
49.9
80
127
C61
ICD-10 Finland
Malignant neoplasm of prostate
5.0
48.8
128
323
117
Kela drug reimbursment
Leukaemia and other malignant diseases of the blood and bone marrow, and malignant diseases of the lymphatic tissue
6.9
47.0
80
135
WZB00
NOMESCO Finland
Telephone prescription or other care instructions
3.8
45.9
229
919
115
Kela drug reimbursment
Breast cancer
5.3
45.3
107
246
M87.0
ICD-10 Finland
Idiopathic aseptic necrosis of bone
18.4
44.1
36
21
192
Kela drug reimbursment
Fulvestrant
67.7
43.1
49
8
H02AB06
ATC
prednisolone; systemic
3.8
42.8
342
1832
WZC10
NOMESCO Finland
Written specialist consultation based on a referral from a dentist or a physician
7.0
41.4
68
110
A06AH03
ATC
naloxegol; oral
14.6
41.2
38
28
K10.25
ICD-10 Finland
Sequences of jawbones
64.7
41.0
47
8
SXB00
NOMESCO Finland
Removal of sutures from oral mucosa
5.6
40.8
87
182
L02BA01
ATC
tamoxifen; oral
7.2
40.7
65
102
WD125
NOMESCO Finland
Demanding cystostatic therapy of methastized malignancy
6.2
39.9
75
139
EBA10
NOMESCO Finland
Operative extraction of tooth
4.9
39.8
102
250
394
Kela drug reimbursment
Palbociclib
56.2
39.3
46
9
XX3DW
NOMESCO Finland
Time consuming IT work
4.1
38.0
128
386
WD325
NOMESCO Finland
Demanding therapy of methastized malignancy with biomodifiers
16.0
37.7
33
22
K10.20
ICD-10 Finland
Osteomyelitis (neonatal) of jaw (acute)(chronic)(suppurative)
205.3
37.3
38
*
L02BG04
ATC
letrozole; oral
5.1
36.4
85
192
EDW99
NOMESCO Finland
Other operation on mandible
102.7
35.2
38
*
WZC30
NOMESCO Finland
Teaching
3.6
35.2
151
535
K10.21
ICD-10 Finland
Osteoradionecrosis of jaw (acute)(chronic)(suppurative)
133.0
35.2
37
*
ZX012
NOMESCO Finland
Radiotherapy with large shaped fields - isocentric therapy
5.1
33.6
79
179
NF1AA
NOMESCO Finland
Hip X-ray examination
4.3
33.2
99
271
L01XE33
ATC
[U] palbociclib
96.9
33.2
36
*
YL1BD
NOMESCO Finland
Extensive CT examination of pelvis for dose design of radiotherapy
8.5
32.9
44
56
L95
ICPC
Osteoporosis
6.4
32.7
58
101
GD1AA
NOMESCO Finland
Thorax X-ray examination
3.2
32.7
335
1956
M05BA04
ATC
alendronic acid; oral
4.4
32.2
94
253
C03CA01
ATC
furosemide; systemic
3.0
31.9
240
1176
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
3.1
31.8
329
1920
329
Kela drug reimbursment
Lenalidomide
45.6
31.4
38
9
TPH04
NOMESCO Finland
Cathetrisation of vein
3.2
31.3
182
770
L04AA06
ATC
mycophenolic acid; systemic
11.7
30.5
32
29
SXC05
NOMESCO Finland
Other oral or dental procedure
5.5
30.5
63
127
L01EF01
ATC
palbociclib; oral
72.7
30.3
34
5
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
3.6
29.9
121
409
B03XA02
ATC
darbepoetin alfa; parenteral
8.6
28.1
37
46
DM1QA
NOMESCO Finland
Paranasal sinuses X-ray examination in one projection
5.5
28.0
58
117
M87.9
ICD-10 Finland
Osteonecrosis, unspecified
27.3
27.9
38
15
PJD52
NOMESCO Finland
Block dissection of axillary lymph nodes
6.0
27.9
52
95
HAC20
NOMESCO Finland
Total mastectomy
5.9
27.8
53
99
J01EE01
ATC
sulfamethoxazole and trimethoprim; systemic
4.8
27.6
67
155
WZC05
NOMESCO Finland
Specialty-specific consultation based on referral by dentist or doctor
5.6
27.5
56
111
D70.82
ICD-10 Finland
Drug-induced neutropenia
10.0
27.3
32
34
SPAT1256
SPAT
Intramuscular and subcutaneous injection
2.8
27.2
288
1650
9732/3-C42.1
ICD-O-3
Plasma cell myeloma of bone marrow
24.9
26.5
37
16
H02AB09
ATC
hydrocortisone; systemic
8.5
26.3
35
44
EDA10
NOMESCO Finland
Biopsy of mandible
+∞
26.3
25
*
5BA08, ,
NOMESCO Finland
33.1
26.3
34
11
A02BC02
ATC
pantoprazole; systemic
3.5
26.2
411
2877
N03AX16
ATC
[U] pregabalin
2.9
26.0
177
804
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
3.6
25.9
99
320
NA2AA
NOMESCO Finland
Thoracal spine X-ray examination without contrast
6.8
25.7
42
67
YN7AD
NOMESCO Finland
CT examination of spine for dose design of radiotherapy
61.4
25.3
29
5
A28
ICPC
Limited function/disability NOS
3.0
25.2
148
620
M05BA06
ATC
ibandronic acid; systemic
7.7
24.9
36
50
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
4.4
24.7
67
169
L04AD01
ATC
ciclosporin; systemic
10.2
24.3
28
29
K08.1
ICD-10 Finland
Loss of teeth due to accident, extraction or local periodontal disease
3.3
24.3
110
395
WD115
NOMESCO Finland
Multiple cystostatic therapy of methastized malignancy
8.5
24.1
32
40
ZX090
NOMESCO Finland
Other technic of radiotherapy
5.8
23.5
45
84
J18.9
ICD-10 Finland
Pneumonia, unspecified
2.7
23.4
183
886
K04.5
ICD-10 Finland
Chronic apical periodontitis
2.7
23.3
187
916
SAA02
NOMESCO Finland
Basic examination of mouth
2.8
22.9
363
2454
NE1BG
NOMESCO Finland
Pelvic, hip and femur MRI examination with high intensity magnet
6.0
22.5
41
73
L01BC06
ATC
capecitabine; oral
5.0
22.3
51
112
AA3AI
NOMESCO Finland
Cone beam CT of facial bones
23.5
22.0
31
14
NK6QA
NOMESCO Finland
Measurement of bone density from two or more locations with X-ray
4.1
21.5
64
173
J01MA12
ATC
levofloxacin; systemic
2.8
21.5
142
627
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
3.2
21.3
100
365
L04AX01
ATC
azathioprine; systemic
5.5
20.9
42
82
C50.99
ICD-10 Finland
Breast, unspecified
6.2
20.9
37
64
K08.3
ICD-10 Finland
Retained dental root
3.8
20.9
69
201
EBA00
NOMESCO Finland
Extraction of tooth
2.5
20.7
219
1208
FB1BD
NOMESCO Finland
Extensive CT examination of arteria pulmonalis
3.7
20.7
73
222
J01FF01
ATC
clindamycin; systemic
2.5
20.7
185
945
NE1CG
NOMESCO Finland
Pelvic, hip and femur extensive MRI examination with high intensity magnet
7.3
20.6
31
45
318
Kela drug reimbursment
Teriparatide
50.3
20.3
24
5
ZYC01
NOMESCO Finland
Remote contact by phone
4.2
20.3
58
152
M05BB03
ATC
alendronic acid and colecalciferol; oral
6.4
20.1
34
56
5BX04, ,
NOMESCO Finland
+∞
19.9
19
*
SAA01
NOMESCO Finland
Simple examination of mouth
2.7
19.8
385
2773
L02BG03
ATC
anastrozole; oral
8.1
19.7
27
35
SPAT1254
SPAT
Administration of medicine
2.9
19.6
112
456
8500/3-C50.9
ICD-O-3
Infiltrating duct carcinoma, NOS, of breast, NOS
4.5
19.6
50
120
H05AA02
ATC
teriparatide; parenteral
48.1
19.4
23
5
D64.9
ICD-10 Finland
Anaemia, unspecified
3.2
19.3
90
326
EBA15
NOMESCO Finland
Extraction of multiple teeth
5.1
19.3
42
88
C50.41
ICD-10 Finland
Malignant tumor of the upper outer quadrant of the mammary gland, ductal tumor
4.1
19.3
57
153
B01AB05
ATC
enoxaparin; parenteral
2.4
19.2
219
1239
K05.31
ICD-10 Finland
Periodontitis pronounced
3.1
19.2
93
345
SPF00
NOMESCO Finland
Reparation of dental prosthesis without impressions
5.8
19.1
36
66
YN7BD
NOMESCO Finland
Extensive CT examination of spine for dose design of radiotherapy
57.4
19.1
22
*
N02AX02
ATC
tramadol; systemic, rectal
2.3
19.0
270
1678
NE1AA
NOMESCO Finland
Pelvis X-ray examination
3.4
18.9
75
246
EFA20
NOMESCO Finland
Decortication of jaws
+∞
18.9
18
*
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
2.6
18.7
140
652
A06AD11
ATC
lactulose; oral
2.8
18.5
111
462
3054, ,
Kela drug reimbursment
31.4
18.5
24
8
1523, ,
Kela drug reimbursment
31.4
18.5
24
8
EBA12
NOMESCO Finland
Demanding operative extraction of tooth
6.9
18.5
29
44
EDB00
NOMESCO Finland
Partial excision of mandible
45.9
18.4
22
5
TPX10
NOMESCO Finland
Implantation of vascular injection port
5.8
18.1
34
62
N02AJ06
ATC
codeine and paracetamol; systemic
2.3
18.1
258
1594
L04AX06
ATC
pomalidomide; oral
34.4
18.1
23
7
L01CA04
ATC
vinorelbine; systemic
17.4
18.1
28
17
1CD02, ,
NOMESCO Finland
19.0
18.0
27
15
WX199
NOMESCO Finland
Other local analgesia
5.3
17.9
37
74
TPH20
NOMESCO Finland
Insertion of central venous catheter through subclavian or brachiocephalic vein
5.5
17.8
35
67
M81.9
ICD-10 Finland
Osteoporosis, unspecified
4.4
17.7
47
116
Z94.8
ICD-10 Finland
Other transplanted organ and tissue status
25.1
17.5
24
10
A07AA02
ATC
nystatin; oral
3.8
17.5
57
164
M80.0
ICD-10 Finland
Postmenopausal osteoporosis with pathological fracture
6.7
17.3
28
44
M80.9
ICD-10 Finland
Unspecified osteoporosis with pathological fracture
6.5
16.9
28
45
L03AA14
ATC
lipegfilgrastim; parenteral
6.5
16.9
28
45
M05BA07
ATC
risedronic acid; oral
5.0
16.9
37
78
WW200
NOMESCO Finland
Immunization
6.1
16.8
30
52
WX110
NOMESCO Finland
Infiltration anesthesia
2.5
16.7
377
2786
SPAT1255
SPAT
Intravenous administration of medicine
3.7
16.6
57
170
YX9AD
NOMESCO Finland
Other CT eamination for dose design of radiotherapy
5.4
16.2
33
65
N02BE01
ATC
paracetamol; systemic, rectal
5.8
16.1
477
4026
SAA04
NOMESCO Finland
Special examination of mouth
4.0
15.9
47
126
NB1AA
NOMESCO Finland
Shoulder X-ray examination without contrast
3.3
15.8
63
207
C78.0
ICD-10 Finland
Secondary malignant neoplasm of lung
6.3
15.7
27
45
127
Kela drug reimbursment
Transplant complication
12.3
15.7
28
24
K10.28
ICD-10 Finland
Other inflammatory condition of the jaws
+∞
15.7
15
*
SPF20
NOMESCO Finland
Temporary relining of dentures
20.0
15.7
23
12
NF1DA
NOMESCO Finland
X-ray of hips
6.0
15.6
28
49
EB1AA
NOMESCO Finland
Intraoral radiographic dental examination
2.2
15.3
292
1980
TEW99
NOMESCO Finland
Other minor procedure in surgery of teeth, jaws, mouth and pharynx
4.1
15.3
43
111
WX290
NOMESCO Finland
Other blockage of nerve
2.1
15.3
237
1485
H02AB07
ATC
prednisone; oral
2.7
15.2
97
414
N03AX12
ATC
[U] gabapentin; oral
2.4
15.2
123
589
R2130
NOMESCO Finland
Counselling and guidance which enhance independent living
3.2
14.8
65
226
393
Kela drug reimbursment
Pomalidomide
26.0
14.8
20
8
ZXD05
NOMESCO Finland
Urgent procedure
2.2
14.8
174
976
C77.8
ICD-10 Finland
Secondary and unspecified malignant neoplasm: Lymph nodes of multiple regions
21.9
14.8
21
10
XX7FT
NOMESCO Finland
Radioyttrium therapy with connected antibody
82.6
14.6
16
*
ECA99
NOMESCO Finland
Other excision of gingiva or alveolar ridge
82.6
14.6
16
*
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
2.6
14.6
101
448
WD415
NOMESCO Finland
Demanding antibody therapy of methastized malignancy
6.8
14.6
23
35
WD135
NOMESCO Finland
Demanding cystostatic therapy of methastized malignancy
16.0
14.5
23
15
WD405
NOMESCO Finland
Simple antiboidy therapy of methastized malignancy
4.8
14.4
33
72
NF3AA
NOMESCO Finland
Femur X-ray examination
5.5
14.4
28
53
Z46.8
ICD-10 Finland
Fitting and adjustment of other specified devices
5.3
14.3
29
57
WVA30, ,
SPAT
3.7
14.1
47
137
J01DB01
ATC
cefalexin; oral
2.8
14.0
434
3528
L01BA01
ATC
methotrexate; systemic
4.8
14.0
32
70
1507
Kela drug reimbursment
Pomalidomide
24.6
13.9
19
8
C50.91
ICD-10 Finland
Malignant tumor in another specified localization in ductal mammary gland
6.7
13.8
22
34
YL1AD
NOMESCO Finland
CT examination of pelvis for dose design of radiotherapy
6.1
13.6
24
41
SPAT1230
SPAT
Aid fitting and borrowing and monitoring of use
2.4
13.6
112
538
NA3AD
NOMESCO Finland
Lumbar spine and sacrum CT examination
5.2
13.5
28
56
ECW99
NOMESCO Finland
Other operation on gingiva or alveolar ridge
143.8
13.5
14
*
T81.4
ICD-10 Finland
Infection following a procedure, not elsewhere classified
2.8
13.5
76
304
N05CF01
ATC
zopiclone; oral
2.1
13.4
192
1153
P01AB01
ATC
metronidazole; oral, rectal
2.0
13.4
223
1415
L04AA01
ATC
[U] ciclosporin
14.3
13.4
22
16
J01MA02
ATC
ciprofloxacin; systemic
2.0
13.2
225
1437
KH1AE
NOMESCO Finland
Urinary tract ultrasound examination
3.4
13.2
51
164
B01AB10
ATC
tinzaparin; parenteral
2.7
13.1
75
302
J05AB11
ATC
valaciclovir; oral
2.5
13.0
99
458
WW300
NOMESCO Finland
Transfer of autologic stem cells
23.3
13.0
18
8
R06AE07
ATC
cetirizine; oral
2.0
12.9
226
1455
DM1AA
NOMESCO Finland
Paranasal sinuses X-ray examination without contrast
4.5
12.8
32
75
HA1AE
NOMESCO Finland
Ultrasound examination of mammary glands
3.3
12.8
51
167
Z3231
NOMESCO Finland
Registered nurse
2.1
12.7
166
959
NFB30
NOMESCO Finland
Primary total prosthetic replacement of hip joint not using cement
3.1
12.7
58
206
ZXE30
NOMESCO Finland
More than five and less than seven hours
3.8
12.7
40
112
KE1AT
NOMESCO Finland
Biopsy of prostata with ultrasoudnguidance
3.1
12.5
57
202
K10.26
ICD-10 Finland
Periostitis of jaw (acute)(chronic)(suppurative)
133.2
12.5
13
*
XX7AT
NOMESCO Finland
Radiation therapy with Radium-223
133.2
12.5
13
*
M87.3
ICD-10 Finland
Other secondary osteonecrosis
38.6
12.3
15
*
JN4CD
NOMESCO Finland
Very extensive body CT
3.8
12.3
39
110
L02AE03
ATC
goserelin; implant
12.8
12.2
21
17
NE1AD
NOMESCO Finland
Pelvis and hip bones CT examination
5.0
12.0
26
54
SXC03
NOMESCO Finland
Other oral or dental procedure
12.1
11.9
21
18
GA5AA
NOMESCO Finland
Rib X-ray examination
30.9
11.7
15
5
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
2.3
11.6
105
522
N13.3
ICD-10 Finland
Other and unspecified hydronephrosis
5.9
11.6
21
37
SPA00
NOMESCO Finland
Changing form of teeth in prepation for prosthodontic work
3.8
11.6
36
100
XX1XQ
NOMESCO Finland
Other SPECT-CT
+∞
11.5
11
*
NA1AA
NOMESCO Finland
Cervical spine X-ray examination without contrast
3.9
11.5
34
91
EEW99
NOMESCO Finland
Other operation on maxilla
122.7
11.5
12
*
NA3BG
NOMESCO Finland
Lumbar spine MRI examination with high intensity magnet
2.6
11.5
71
297
WYA30
NOMESCO Finland
Treatment of a patient needing special arrangements
3.0
11.4
53
190
M05BA02
ATC
clodronic acid; systemic
17.6
11.3
17
10
X59
ICD-10 Finland
Exposure to unspecified factor
2.2
11.3
111
572
A04AA55
ATC
palonosetron, combinations; systemic
3.9
11.2
33
88
WW409
NOMESCO Finland
Other aferesis
25.7
11.2
15
6
WD515
NOMESCO Finland
Demanding therapy of malignancy with enzyme inhibitors and similar treatments
20.6
11.2
16
8
R52.2
ICD-10 Finland
Other chronic pain
4.0
11.1
32
84
GD1DD
NOMESCO Finland
High resolution CT examination of lungs
3.4
11.1
42
133
R4110
NOMESCO Finland
Physiotherapy
2.0
11.1
167
1009
N02BF02
ATC
pregabalin; oral
3.2
10.9
44
145
C78.7
ICD-10 Finland
Secondary malignant neoplasm of liver and intrahepatic bile duct
4.5
10.9
27
63
WX704
NOMESCO Finland
Intubation
2.9
10.9
53
195
K12.2
ICD-10 Finland
Cellulitis and abscess of mouth
15.9
10.9
17
11
ZXE20
NOMESCO Finland
More than three and less than five hours
2.3
10.8
93
452
AA1AD
NOMESCO Finland
CT of head and brain
2.0
10.8
170
1040
ZXA05
NOMESCO Finland
Left side
2.0
10.8
154
911
C77.5
ICD-10 Finland
Secondary and unspecified malignant neoplasm: Intrapelvic lymph nodes
28.7
10.8
14
5
NK6CT
NOMESCO Finland
Bone biopsy with CT guidance
28.7
10.8
14
5
C91.0
ICD-10 Finland
Acute lymphoblastic leukaemia [ALL]
61.3
10.7
12
*
EFB10
NOMESCO Finland
Osteoplasty on jaws
61.3
10.7
12
*
TPH07
NOMESCO Finland
Cathetrisation of artery
2.4
10.6
80
367
B03XA01
ATC
erythropoietin; parenteral
10.4
10.6
20
20
QX2XE
NOMESCO Finland
Ultrsound examination of soft tissue not elsewhere classified
4.1
10.4
29
74
JN3BD
NOMESCO Finland
Extensive abdominal CT
2.5
10.4
70
304
HA1AA
NOMESCO Finland
X-ray mammography
2.8
10.4
53
200
J01MA14
ATC
moxifloxacin; systemic
2.6
10.4
64
267
TPH90
NOMESCO Finland
Removal of fixed intravenous catheter
10.9
10.4
19
18
JN3AD
NOMESCO Finland
Abdominal CT examination
2.5
10.4
74
331
166
Kela drug reimbursment
Dalteparin and tinzaparin (treatment for more than 6 months)
9.9
10.3
20
21
SPE90
NOMESCO Finland
Other partial denture
4.9
10.3
23
49
EJ2S1
NOMESCO Finland
Photography of oral mucosa
19.3
10.3
15
8
C50.90
ICD-10 Finland
Malignant tumor in other or unspecified location in mammary gland without histology
7.7
10.3
23
31
WX2DD
NOMESCO Finland
Low-dose CT of skeleton in whole body
23.9
10.3
14
6
WX892
NOMESCO Finland
Monitored bed care
2.7
10.3
57
225
C50.4
ICD-10 Finland
Malignant neoplasm: Upper-outer quadrant of breast
13.5
10.2
17
13
N02AA01
ATC
morphine; systemic, rectal
5.4
10.2
20
38
SBB00
NOMESCO Finland
Clinical photography of mouth and teeth
4.5
10.2
25
58
NB6AA
NOMESCO Finland
Humerus X-ray examination
5.2
10.1
21
42
THW99
NOMESCO Finland
Other minor procedure in surgery of mammary gland
4.8
10.1
23
50
WZA90
NOMESCO Finland
Other medical or dental certificate
2.0
10.1
135
778
L04AX03
ATC
methotrexate; systemic
2.5
10.1
65
277
M80.4
ICD-10 Finland
Drug-induced osteoporosis with pathological fracture
15.0
10.1
16
11
TQW40
NOMESCO Finland
Remowal of suture of skin
2.9
10.0
48
175
Z01.2
ICD-10 Finland
Dental examination
1.8
10.0
226
1547
Z50.9
ICD-10 Finland
Care involving use of rehabilitation procedure, unspecified
3.6
9.9
33
96
J01CA04
ATC
amoxicillin; systemic
2.2
9.9
409
3395
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
2.5
9.9
68
299
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
2.3
9.8
80
379
NK4XE
NOMESCO Finland
Joint ultrasound examination not elsewhere classified
3.0
9.8
45
160
Z01.8
ICD-10 Finland
Other specified special examinations
2.0
9.8
132
761
NA7EA
NOMESCO Finland
Scoliosis X-ray examination
7.6
9.8
22
30
-50
ICPC
Medication/prescr/renewal
3.4
9.8
36
112
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
2.6
9.7
60
250
XX9AN
NOMESCO Finland
Complementary isotope examination or additional picture
56.1
9.7
11
*
L01EF03
ATC
abemaciclib; oral
56.1
9.7
11
*
AA1CD
NOMESCO Finland
Very extensive CT of head and brain
5.2
9.6
20
40
ZX013
NOMESCO Finland
Radiotherapy with large shaped fields - SSD therapy
11.7
9.6
17
15
GD1AD
NOMESCO Finland
Thorax CT examination
2.9
9.6
48
179
A46
ICD-10 Finland
Erysipelas
2.2
9.5
93
476
YNB10
NOMESCO Finland
Collection of stem cells for transplant
101.9
9.4
10
*
Y57
ICD-10 Finland
Adverse effects in the therapeutic use of other and unspecified drugs and medicaments
5.3
9.4
19
37
SXC02
NOMESCO Finland
Other oral or dental procedure, restricted
4.5
9.4
23
53
NA7DG
NOMESCO Finland
Spine and spinal cord very extensive MRI examination with high intensity magnet
7.1
9.4
22
32
ZXA00
NOMESCO Finland
Right side
1.9
9.4
163
1022
3030
Kela drug reimbursment
Abemaciclib
+∞
9.4
9
*
1515, ,
Kela drug reimbursment
+∞
9.4
9
*
KA1AE
NOMESCO Finland
Kidney ultrasound examination
4.3
9.3
24
58
NJ3DA
NOMESCO Finland
Long bones of extremities X-ray examination
14.0
9.2
15
11
ZX108
NOMESCO Finland
Inhalation
14.0
9.2
15
11
Z51.1
ICD-10 Finland
Chemotherapy session for neoplasm
8.0
9.2
20
26
WX404
NOMESCO Finland
Intravenous generell anesthesy
2.0
9.1
119
677
Z2446
NOMESCO Finland
Social worker
2.8
9.1
46
173
WPA10
NOMESCO Finland
Proactive palliative care treatment plan
16.0
9.1
14
9
EBA05
NOMESCO Finland
Complicated extraction of tooth
2.0
9.1
118
671
1XX32, ,
NOMESCO Finland
37.4
9.0
11
*
Z3226
NOMESCO Finland
Physiotherapist
2.0
9.0
111
618
K13.79
ICD-10 Finland
Change in the oral mucosa UNS
4.3
9.0
23
55
M81.0
ICD-10 Finland
Postmenopausal osteoporosis
3.9
9.0
27
73
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
2.6
9.0
54
222
EDA00
NOMESCO Finland
Incision of mandibular abscess
19.0
9.0
13
7
NK6AQ
NOMESCO Finland
Whole body bone SPET with low dose CT
24.5
8.9
12
5
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
1.8
8.9
239
1704
L97
ICD-10 Finland
Ulcer of lower limb, not elsewhere classified
3.6
8.9
30
88
J15.9
ICD-10 Finland
Bacterial pneumonia, unspecified
2.5
8.9
56
236
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
2.3
8.9
70
327
ZX080
NOMESCO Finland
Image guided radiotherapy
4.3
8.8
23
56
XX9AW
NOMESCO Finland
Production of copy from X-ray picture
3.6
8.8
29
84
K05.30
ICD-10 Finland
Periodontitis complex
2.1
8.8
90
468
B01AB04
ATC
dalteparin; parenteral
3.2
8.8
36
120
L28
ICPC
Limited function/disability (L)
2.0
8.7
110
617
E0000UV, ,
ATC
1.8
8.7
215
1493
C50.21
ICD-10 Finland
Malignant tumor of the upper inner quadrant of the mammary gland,ductal tumor
4.4
8.7
22
52
K04.1
ICD-10 Finland
Necrosis of pulp
2.4
8.7
62
276
C50.9
ICD-10 Finland
Malignant neoplasm: Breast, unspecified
14.4
8.7
14
10
8520/3-C50.9
ICD-O-3
Lobular carcinoma, NOS, of breast, NOS
7.9
8.7
19
25
M87
ICD-10 Finland
Osteonecrosis
50.9
8.7
10
*
EEA10
NOMESCO Finland
Biopsy of maxilla
50.9
8.7
10
*
EB1CA
NOMESCO Finland
Tooth X-ray additional picture
2.5
8.7
55
232
SPAT1148
SPAT
Treatment of chronic ulcer or burn
2.1
8.6
87
449
K02.1
ICD-10 Finland
Caries of dentine
1.8
8.6
280
2103
SPAT1088
SPAT
Blood transfusion
16.6
8.6
13
8
N17.9
ICD-10 Finland
Acute renal failure, unspecified
3.4
8.5
31
96
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
1.8
8.5
172
1126
H05BA01
ATC
calcitonin (salmon synthetic); nasal, parenteral
3.8
8.4
26
72
UGC12
NOMESCO Finland
Flexible bronchoscopy
2.5
8.4
57
249
EDB99
NOMESCO Finland
Other excision on mandible
+∞
8.4
8
*
C50.40
ICD-10 Finland
Malignant tumor of the upper outer quadrant of the mammary gland, no histological veryfication
4.2
8.3
22
54
ZXM00
NOMESCO Finland
Intraoperative use of ultrasonographic imaging
11.0
8.3
15
14
WX402
NOMESCO Finland
General anaesthesia
2.0
8.3
111
636
A04.7
ICD-10 Finland
Enterocolitis due to Clostridium difficile
4.0
8.2
23
59
S81.8
ICD-10 Finland
Open wound of other parts of lower leg
3.6
8.2
27
78
NF1AE
NOMESCO Finland
Hip joint ultrasound examination
4.7
8.2
19
42
M16.7
ICD-10 Finland
Other secondary coxarthrosis
12.0
8.1
14
12
WD215
NOMESCO Finland
Multiple therapy of methastized malignancy with hormones
33.9
8.1
10
*
M87.8
ICD-10 Finland
Other osteonecrosis
33.9
8.1
10
*
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
1.8
8.1
164
1071
A01
ICPC
Pain general/multiple sites
2.4
8.1
61
279
WX408
NOMESCO Finland
General anesthesy, balanced
1.8
8.1
143
896
K10.3
ICD-10 Finland
Alveolitis of jaws
3.3
8.1
30
94
Z2221
NOMESCO Finland
Medical doctor
1.8
8.1
145
913
ECB00
NOMESCO Finland
Suture of gingiva
3.5
8.1
28
84
WVA30
NOMESCO Finland
Intramuscular and subcutaneous injection
22.4
8.0
11
5
SBB10
NOMESCO Finland
Dental impressions
2.9
8.0
39
144
AA1BD
NOMESCO Finland
Extensive CT of head and brain
4.1
8.0
22
56
A41.9
ICD-10 Finland
Sepsis, unspecified
3.4
7.9
29
90
C50.81
ICD-10 Finland
Overall malignant tumor of the mammary gland, ductal tumor
6.3
7.9
20
33
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
2.2
7.9
67
322
M81.8
ICD-10 Finland
Other osteoporosis
8.7
7.9
16
19
D40.0
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Prostate
7.1
7.8
18
26
KC1EE
NOMESCO Finland
Ultrasound measurement of residual urine
2.0
7.8
90
488
A11CC03
ATC
alfacalcidol; systemic
4.5
7.7
19
44
J05AB01
ATC
aciclovir; systemic
1.9
7.7
122
736
S97
ICPC
Chronic ulcer skin
2.5
7.7
49
207
N06AX21
ATC
duloxetine; oral
2.3
7.7
64
306
TPH30
NOMESCO Finland
Insertion of central venous catheter through periferal vein
6.9
7.7
18
27
DM1AD
NOMESCO Finland
CT of paranasal sinuses and face area
3.6
7.6
25
72
M49.5*C79.5
ICD-10 Finland
Metastatic fracture of vertebra
25.4
7.6
10
*
M16.6
ICD-10 Finland
Other secondary coxarthrosis, bilateral
25.4
7.6
10
*
ECA20
NOMESCO Finland
Biopsy of gingiva
9.1
7.6
15
17
YX9BD
NOMESCO Finland
Other extensive CT eamination for dose design of radiotherapy
10.3
7.6
14
14
L88
ICPC
Rheumatoid/seropositive arthritis
3.2
7.5
29
93
TNX50
NOMESCO Finland
Removal of cutom molded cast and internal stretch
3.1
7.5
32
109
TNX10
NOMESCO Finland
Arthrocentesis, unspecified region, unspecified region
2.5
7.5
47
197
GD1BD
NOMESCO Finland
Thorax extensive CT-examination
2.7
7.5
42
167
E83.50
ICD-10 Finland
Hypercalcemia
7.8
7.4
16
21
L01XG03
ATC
ixazomib; oral
81.3
7.4
8
*
NC1AA
NOMESCO Finland
Elbow X-ray examination without contrast
3.5
7.3
25
74
L04AA13
ATC
[U] leflunomide
4.3
7.3
19
46
EN1AD
NOMESCO Finland
CT examination of mouth and soft tissues of neck
9.6
7.3
14
15
G03HA01
ATC
cyproterone; systemic
9.6
7.3
14
15
K10.29
ICD-10 Finland
Inflammatory condition of the jaws UNS
+∞
7.3
7
*
WW402
NOMESCO Finland
Leucoferesis
+∞
7.3
7
*
M90.7*C90.0
ICD-10 Finland
Pathological fracture in multiple myeloma
+∞
7.3
7
*
EFW99
NOMESCO Finland
Other operation on jaws
+∞
7.3
7
*
ECA40
NOMESCO Finland
Surgical treatment of periodontal abscess
+∞
7.3
7
*
RS221, ,
NOMESCO Finland
7.5
7.2
16
22
H02AB04
ATC
methylprednisolone; systemic
2.0
7.2
82
442
QBB10
NOMESCO Finland
Major dressing of wound of skin of trunk
3.6
7.2
24
70
EEB00
NOMESCO Finland
Partial excision of maxilla
30.5
7.2
9
*
NA3DG
NOMESCO Finland
Lumbar spine very extensive MRI examination with high intensity magnet
10.2
7.1
13
13
Z94.0
ICD-10 Finland
Kidney transplant status
10.2
7.1
13
13
C50.11
ICD-10 Finland
Malignant tumor of the central part of the mammary gland,ductal tumor
7.2
7.0
16
23
PH1AE
NOMESCO Finland
Ultrasound examination of upper extremity veins
5.6
7.0
19
35
WX725
NOMESCO Finland
Noninvasive ventilation
2.7
7.0
37
143
R60.0
ICD-10 Finland
Localized oedema
2.0
6.9
76
404
NA1BG
NOMESCO Finland
Cervical spine MRI examination with high intensity magnet
2.8
6.9
34
126
123
Kela drug reimbursment
Chronic disorders of vitamin D metabolism
4.2
6.9
18
44
HAE20
NOMESCO Finland
Reconstruction of areola and mamilla using graft or flap
8.4
6.9
14
17
ZXD30
NOMESCO Finland
Difficulties in perfomrming procedure
3.0
6.9
30
104
EB1WA, ,
NOMESCO Finland
11.1
6.8
12
11
ZXE10
NOMESCO Finland
More than one and less than three hours
1.7
6.8
189
1336
L04AX02
ATC
thalidomide; oral
40.6
6.8
8
*
1CX01, ,
NOMESCO Finland
40.6
6.8
8
*
YN1AD
NOMESCO Finland
CT examination of extremities for dose design of radiotherapy
40.6
6.8
8
*
ZXC20
NOMESCO Finland
Use of chemical agents
4.0
6.8
19
49
SPAT1263
SPAT
Sampling
1.6
6.7
214
1563
WX105
NOMESCO Finland
Surface analgesia on skin or mucosa
2.3
6.7
54
254
M05.9
ICD-10 Finland
Seropositive rheumatoid arthritis, unspecified
3.8
6.7
20
54
QDB10
NOMESCO Finland
Major dressing of wound of skin of lower limb
2.7
6.7
36
140
TKC20
NOMESCO Finland
Catheterisation of bladder
2.4
6.7
46
202
SHA02
NOMESCO Finland
Stomatognathic treatment, basic
2.7
6.6
36
141
138
Kela drug reimbursment
Severe anaemia associated with chronic renal failure
4.3
6.6
17
41
ZY010
NOMESCO Finland
Hospital outpatient
3.0
6.5
28
96
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
2.5
6.5
43
185
TNE25
NOMESCO Finland
Drill biopsy of bone marrow, pelvis
6.3
6.5
16
26
D70.89
ICD-10 Finland
Neutropenic splenomegaly
6.3
6.5
16
26
ZXE13
NOMESCO Finland
Procedure duration 90 to 119 minutes
3.4
6.5
23
70
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
1.9
6.5
86
489
XKD00
NOMESCO Finland
Uroflowmetry
1.9
6.5
96
566
NA1EA
NOMESCO Finland
Cervical spine X-ray examination with flexion
7.5
6.4
14
19
XX7JT
NOMESCO Finland
Somatostatin isotope ablative therapy
70.7
6.4
7
*
M05BA08
ATC
zoledronic acid; parenteral
70.7
6.4
7
*
SPAT1229
SPAT
Assessment of need for aid
2.3
6.4
49
225
Y83
ICD-10 Finland
Surgical operation and other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
2.4
6.4
45
199
N39.0
ICD-10 Finland
Urinary tract infection, site not specified
1.9
6.4
83
467
KA2AE
NOMESCO Finland
Ultrasound examination transplanted kidney
14.5
6.4
10
7
GA1AE
NOMESCO Finland
Ultrasound examination of thorax
3.7
6.4
20
56
S32.0
ICD-10 Finland
Fracture of lumbar vertebra
3.3
6.4
24
76
ZY020
NOMESCO Finland
Telephone, letter or other consultation without direct patient contact
2.4
6.4
42
181
SPAT1222
SPAT
Counselling/guidance promoting independent living
1.9
6.3
88
507
E78.0
ICD-10 Finland
Pure hypercholesterolaemia
0.4
6.3
34
761
EB1JA
NOMESCO Finland
Double panorama tomography of teeth and jaws or similar X-ray examination
11.2
6.3
11
10
M05BX03
ATC
strontium ranelate; oral
11.2
6.3
11
10
NA3CG
NOMESCO Finland
Lumbar spine extensive MRI examination with high intensity magnet
3.0
6.3
28
98
M81.4
ICD-10 Finland
Drug-induced osteoporosis
18.3
6.3
9
5
Z71.3
ICD-10 Finland
Dietary counselling and surveillance
2.9
6.3
29
104
WW302
NOMESCO Finland
Allogenic transfer of stem cells from relative
+∞
6.3
6
*
D63.0
ICD-10 Finland
Anaemia in neoplastic disease
+∞
6.3
6
*
T86.0
ICD-10 Finland
Bone-marrow transplant rejection
27.0
6.2
8
*
C50.1
ICD-10 Finland
Malignant neoplasm: Central portion of breast
27.0
6.2
8
*
1505
Kela drug reimbursment
Ixazomib
27.0
6.2
8
*
398
Kela drug reimbursment
Ixazomib
27.0
6.2
8
*
313
Kela drug reimbursment
Abatacept, adalimumab, anakinra, certolizumab pegol, etanercept, golimumab, infliximab, ixekizumab, sarilumab, secukinumab, tocilizumab and ustekinumab (rheumatoid diseases)
4.1
6.2
17
43
XF600
NOMESCO Finland
Bloodpressure measurement
2.4
6.2
41
177
N05BA04
ATC
oxazepam; oral
1.7
6.2
131
858
SHB00
NOMESCO Finland
Preparing and fitting the occlusal splint in the mouth
2.5
6.1
39
165
SPAT1203
SPAT
Injection therapy, other than intramuscular or subcutaneous
2.8
6.1
30
111
SPAT1137
SPAT
Taking care of patient’s/customer’s hygiene
2.4
6.1
41
178
RS220, ,
NOMESCO Finland
8.8
6.1
12
14
SFA10
NOMESCO Finland
One-surface restoration
1.6
6.1
256
1989
N02BF01
ATC
gabapentin; oral
2.2
6.1
49
231
WF099
NOMESCO Finland
Other radiotherapy
10.2
6.1
11
11
NK6BQ
NOMESCO Finland
Whole body extensive bone SPET with low dose CT
10.2
6.1
11
11
KAS10
NOMESCO Finland
Allogenic transplantation of kidney from cadaver donor
10.2
6.1
11
11
SPAT1217
SPAT
Assessment of need for services (elderly/care support)
2.2
6.0
50
238
AA1AA
NOMESCO Finland
Head X-ray examination
6.2
6.0
15
25
T88.7
ICD-10 Finland
Unspecified adverse effect of drug or medicament
5.7
6.0
16
29
K59.1
ICD-10 Finland
Functional diarrhoea
2.6
6.0
35
142

LabWAS

↥
OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
444
2234
10.42
78.49
26.9
6.9
1.22
1.21
mmol/l
0.63
396
1921
317
1281
5.09
69.52
7.6
4.2
—
—
—
0
0
348
1513
5.36
69.48
12.0
3.4
2.34
2.35
mmol/l
0.65
330
1318
394
1943
6.00
65.80
12.0
4.7
33.32
35.25
g/l
9.36
381
1804
445
2473
8.77
63.51
38.5
9.2
3.80
4.15
e9/l
2.80
430
2166
208
655
4.75
61.55
2.4
1.9
—
—
—
0
0
393
2057
5.38
57.41
19.3
6.0
1.22
1.21
mmol/l
1.70
387
1871
57
50
12.75
56.10
4.2
2.8
—
—
—
0
0
214
735
4.36
55.55
7.7
3.3
0.80
0.81
mmol/l
1.38
206
692
373
1996
4.50
49.68
15.1
6.0
—
—
—
0
0
376
2036
4.50
48.93
15.9
5.7
24.58
27.05
%
3.83
370
1904
75
114
7.57
48.58
15.2
4.9
—
—
—
0
0
292
1343
3.86
48.10
15.9
4.0
7.39
7.40
ph
0.81
63
246
370
2001
4.34
47.72
16.4
5.8
8.91
8.69
%
0.54
363
1869
368
1993
4.28
47.10
15.8
5.5
2.35
2.84
%
4.11
361
1858
71
105
7.72
47.08
4.4
1.9
—
—
—
0
0
361
1938
4.17
46.59
15.7
5.5
0.61
0.67
%
1.21
356
1805
368
2006
4.23
46.34
15.4
5.5
59.37
57.57
%
1.79
360
1883
382
2171
4.30
44.43
15.1
5.4
1.61
1.93
e9/l
3.38
356
1921
376
2121
4.19
44.03
14.9
5.4
0.59
0.60
e9/l
0.18
347
1827
374
2129
4.08
42.56
15.0
5.4
0.04
0.04
e9/l
2.87
345
1839
170
586
3.89
42.21
10.4
5.2
1.04
1.03
mmol/l
0.15
162
538
380
2196
4.12
42.04
15.9
5.7
0.17
0.19
e9/l
1.01
358
1926
79
151
6.03
40.79
17.7
4.4
119.78
2.11
ratio
—
5
15
79
153
5.95
40.21
19.0
4.5
86.83
88.66
mg/l
0.01
69
119
79
153
5.95
40.21
19.0
4.5
46.44
34.26
mg/l
0.41
69
121
127
395
3.98
35.98
9.2
6.5
9.85
9.76
mmol/l
0.05
122
374
367
2198
3.57
35.56
14.5
15.7
1.20
1.28
inr
1.02
122
629
40
41
10.52
35.20
16.2
2.7
181.64
57.49
u/ml
0.62
40
41
406
2605
4.08
35.01
10.3
4.9
6.73
6.76
mmol/l
0.10
395
2463
96
265
4.25
31.80
3.9
1.7
0.68
1.57
g/l
2.72
85
241
108
327
3.94
31.48
13.0
2.9
—
—
—
0
0
106
318
3.97
31.29
6.0
4.2
0.80
0.56
%
0.84
71
116
31
26
12.65
31.03
3.6
1.9
—
—
—
0
0
53
91
6.40
30.27
3.0
1.7
—
—
—
0
0
30
25
12.71
30.13
3.4
1.6
—
—
—
0
0
164
667
3.18
30.02
2.9
2.4
2.24
2.31
g/l
0.81
155
619
173
728
3.11
29.83
2.9
2.4
12.63
12.73
umol/l
0.06
167
677
203
938
2.97
29.57
3.7
2.6
4.36
4.63
e6/l
0.14
197
848
158
635
3.18
29.44
3.1
2.4
23.07
22.31
%
0.23
136
547
79
201
4.49
28.99
2.1
1.9
1.78
3.05
ug/l
0.38
73
176
39
50
8.38
28.91
4.1
2.5
0.72
1.64
g/24h
1.16
21
26
134
495
3.34
28.65
2.4
1.7
—
—
—
0
0
260
1389
2.83
28.58
4.6
3.3
—
—
—
0
0
257
1369
2.82
28.34
5.3
3.4
515.56
109.22
e6/l
0.46
227
1062
116
407
3.41
26.80
4.6
2.6
75.18
71.82
e9/l
0.38
96
315
326
2005
2.83
26.53
5.1
2.6
—
—
—
0
0
416
2925
3.62
26.48
7.2
4.5
—
—
—
0
0
107
363
3.48
26.01
6.6
4.1
1.30
0.93
%
0.70
75
146
44
73
6.52
25.92
1.7
1.4
—
—
—
0
0
189
895
2.80
25.60
4.7
3.0
533.16
548.87
mosm/kgh2o
0.42
177
768
111
390
3.38
25.49
3.8
3.1
204.23
202.18
ng/l
0.02
103
359
101
343
3.44
24.41
4.4
3.7
72.25
80.06
ng/l
0.41
88
307
183
872
2.74
24.27
6.4
3.1
2.49
2.45
mmol/l
1.34
167
764
290
1734
2.62
24.08
3.5
2.2
83.24
78.49
nmol/l
2.10
274
1525
36
53
7.25
23.66
1.2
1.2
—
—
—
0
0
96
325
3.42
23.25
2.8
2.3
4.46
13.38
nmol/l
15.55
75
293
107
392
3.21
22.76
3.2
1.9
351.13
374.80
nmol/l
0.47
99
366
268
1572
2.53
22.75
6.7
3.9
86.13
91.60
e6/l
0.07
231
1138
74
215
3.87
22.51
2.2
1.9
1.78
1.52
g/l
1.03
67
191
242
1360
2.52
22.44
9.1
3.4
39.66
32.57
u/l
0.65
229
1289
181
888
2.63
22.32
4.8
3.9
287.18
272.42
ng/l
0.04
148
722
242
1377
2.48
21.62
5.4
2.5
—
—
—
0
0
79
254
3.51
20.62
1.7
1.4
—
—
—
0
0
94
338
3.20
20.50
6.9
4.2
0.12
0.16
%
0.30
60
119
207
1119
2.46
20.42
2.7
2.1
2.85
3.20
mg/l
1.46
189
970
105
409
2.99
19.91
1.6
1.4
—
—
—
0
0
89
316
3.21
19.79
6.6
4.3
0.27
1.00
%
0.37
53
98
121
512
2.80
19.68
7.0
4.3
27.66
33.85
ug/l
0.11
109
434
222
1256
2.39
19.58
4.8
3.2
0.42
0.55
e6/l
0.47
198
952
199
1077
2.42
19.36
28.7
6.7
—
—
—
0
0
28
39
7.55
19.26
2.7
2.3
—
—
—
0
0
35
64
5.81
18.63
1.7
1.4
114.67
93.70
u/ml
—
8
10
192
1037
2.39
18.62
4.6
2.4
—
—
—
0
0
83
297
3.16
18.14
4.2
3.8
7.39
7.40
ph
—
9
33
26
13
21.03
17.92
2.7
1.8
55.20
60.64
ug/l
0.15
26
13
36
71
5.39
17.68
1.6
1.2
234.72
270.92
u/ml
0.24
25
39
99
398
2.86
17.58
1.9
1.5
—
—
—
0
0
152
756
2.46
17.55
5.1
1.4
1.99
2.63
g/l
2.66
120
438
26
37
7.36
17.54
1.4
1.2
—
—
—
0
0
271
1725
2.26
17.50
4.1
2.7
265.93
140.81
ug/l
6.75
255
1579
44
105
4.50
17.31
1.5
1.2
—
—
—
0
0
48
126
4.11
16.69
4.1
3.5
—
—
—
0
0
31
57
5.73
16.39
7.5
5.5
10.96
11.57
mg/l
0.25
31
52
28
23
12.83
16.04
3.1
1.6
34.28
33.15
%
0.10
28
23
162
860
2.31
15.91
1.7
1.7
1045.98
1222.72
nmol/l
1.71
142
652
205
1211
2.18
15.40
4.9
3.2
—
—
—
0
0
100
433
2.64
15.25
7.9
3.3
1.59
1.99
mmol/l
0.49
85
356
227
1405
2.14
15.03
3.6
2.4
53.05
62.03
u/l
1.22
215
1295
145
752
2.31
14.90
4.4
3.1
4.18
1.81
e6/l
1.35
89
421
100
438
2.61
14.87
1.9
1.5
—
—
—
0
0
482
4161
6.61
14.40
51.3
15.6
26.49
24.40
mg/l
0.77
459
3333
165
922
2.18
14.02
2.8
1.7
1.23
1.24
mg/l
0.03
135
727
85
353
2.70
14.02
14.9
3.8
1.23
1.23
mmol/l
0.44
85
311
274
1872
2.04
13.39
28.4
9.6
0.01
0.00
e9/l
0.46
239
1531
226
1442
2.04
13.36
4.1
3.1
2004.82
1325.62
ng/l
0.51
208
1243
98
456
2.43
12.70
16.2
4.3
—
—
—
0
0
106
511
2.37
12.69
2.0
1.7
—
—
—
0
0
17
8
21.94
12.08
3.1
2.0
—
—
—
0
0
64
247
2.83
12.08
9.4
9.8
—
—
—
0
0
102
495
2.34
11.98
8.0
2.8
7.96
9.34
umol/l
0.23
93
441
30
72
4.37
11.69
1.1
1.1
—
—
—
0
0
27
61
4.62
11.33
1.5
1.2
—
—
—
0
0
250
1727
1.90
11.09
2.4
2.1
—
—
—
0
0
83
388
2.37
10.54
11.9
8.2
—
—
—
0
0
27
65
4.34
10.48
1.1
1.1
—
—
—
0
0
16
10
16.47
10.41
1.5
1.6
—
—
—
0
0
89
439
2.25
9.95
2.0
2.0
0.21
0.21
g/l
0.04
89
411
14
7
20.53
9.85
3.6
2.0
—
—
—
0
0
20
40
5.17
9.65
1.3
1.1
—
—
—
0
0
56
227
2.65
9.59
4.9
3.8
—
—
—
0
0
16
13
12.67
9.42
2.2
2.7
—
—
—
0
0
102
543
2.11
9.39
1.5
1.3
745.00
487.10
titre
0.53
24
124
23
54
4.42
9.22
4.7
3.9
—
—
—
0
0
28
78
3.74
8.96
2.4
2.5
—
—
—
0
0
29
83
3.65
8.93
1.4
1.2
69.89
22.24
u/l
1.53
29
72
82
410
2.20
8.83
2.3
2.4
29.19
32.27
u/l
0.51
67
341
101
552
2.04
8.62
8.3
7.6
1.76
1.26
mmol/l
0.66
83
451
100
547
2.04
8.51
2.0
1.4
—
—
—
0
0
53
223
2.54
8.41
11.9
3.5
23.52
24.12
mmol/l
0.75
53
218
334
2654
1.79
8.32
4.3
3.2
93.35
52.73
u/l
2.28
321
2453
252
1853
1.73
8.22
2.4
2.0
87.89
95.39
pmol/l
2.00
168
954
35
120
3.06
8.14
2.1
1.6
19500.00
12824.63
e6/l
0.24
26
90
28
84
3.47
8.05
3.5
3.8
—
—
—
0
0
19
29
6.77
7.96
1.6
2.5
32.00
41.83
%
—
8
20
25
70
3.71
7.95
2.2
1.5
—
—
—
0
0
171
1141
1.76
7.78
1.8
1.6
19.07
20.82
nmol/l
0.96
156
969
22
58
3.92
7.60
1.3
1.7
0.65
0.88
g/l
0.30
17
47
23
63
3.78
7.55
1.7
1.4
—
—
—
0
0
23
64
3.72
7.38
1.3
1.1
—
—
—
0
0
193
1355
1.69
7.20
2.6
2.1
130.74
249.64
u/l
1.30
185
1272
12
10
12.26
7.11
1.3
1.5
—
—
—
0
0
13
14
9.50
6.82
2.2
1.1
—
—
—
0
0
377
3183
1.77
6.77
7.6
4.2
20.40
13.07
mm/h
8.24
365
2913
48
219
2.32
6.40
1.3
1.3
—
—
—
0
0
167
1163
1.66
6.24
7.6
2.8
332.97
8192.58
umol/l
5.47
157
1000
235
1782
1.61
6.22
4.9
3.8
33.82
55.33
ng/l
0.59
187
1333
13
17
7.82
6.16
4.2
1.4
—
—
—
0
0
14
21
6.83
6.07
1.2
1.5
—
—
—
0
0
20
58
3.55
6.07
2.5
1.7
33.80
32.72
pg
0.78
20
58
74
411
1.94
5.94
9.1
7.0
1.25
1.35
mmol/l
0.52
74
400
16
40
4.10
5.94
4.1
1.1
—
—
—
0
0
270
2133
1.58
5.89
5.5
3.8
0.00
0.01
estimate
0.50
68
368
267
2108
1.58
5.81
7.2
5.2
0.00
0.00
estimate
-0.00
70
378
17
46
3.79
5.69
1.8
1.4
—
—
—
0
0
12
16
7.66
5.66
1.0
1.1
—
—
—
0
0
16
32
5.13
5.61
1.1
1.1
—
—
—
0
0
11
13
8.62
5.58
1.0
1.1
—
—
—
0
0
41
186
2.31
5.55
1.5
1.6
—
—
—
0
0
21
67
3.23
5.53
2.7
2.0
—
—
—
0
0
19
57
3.43
5.49
1.3
1.3
3341.33
1706.08
e6/l
0.26
12
39
37
162
2.39
5.43
4.0
3.3
1.49
0.24
g/l
0.59
20
67
152
1068
1.61
5.35
1.8
1.3
—
—
—
0
0
264
2108
1.54
5.26
5.5
3.9
0.00
0.00
estimate
0.50
71
412
88
1351
0.58
5.21
3.2
3.1
—
—
—
0
0
183
1358
1.55
5.04
5.0
4.1
—
—
—
0
0
22
77
2.94
4.99
5.1
3.3
54.09
59.19
%
0.82
22
77
21
74
2.92
4.71
4.6
2.8
3.37
4.48
e9/l
1.71
21
74
17
53
3.29
4.65
1.2
1.3
5782.78
58431.17
e6/l
—
9
30
485
4596
3.49
4.58
72.5
23.0
242.92
243.91
e9/l
0.10
480
4484
485
4597
3.48
4.56
72.2
23.1
36.65
40.05
%
21.04
442
4287
23
87
2.72
4.55
3.6
2.5
17.04
16.00
%
0.58
15
43
485
4598
3.47
4.54
72.3
23.0
6.54
6.74
e9/l
1.11
480
4471
485
4598
3.47
4.54
72.2
23.0
4.03
4.47
e12/l
52.60
478
4469
10
15
6.78
4.48
3.6
3.8
62.30
51.00
%
—
10
15
12
23
5.32
4.48
2.1
2.0
572.17
951.70
u/ml
1.08
12
23
33
150
2.29
4.48
6.3
2.1
21.88
21.62
s
0.14
33
137
23
89
2.66
4.37
4.5
4.3
2.27
2.14
mmol/l
0.08
18
59
357
3105
1.53
4.36
5.2
4.2
—
—
—
0
0
7
252
0.27
4.28
1.6
1.4
—
—
—
0
0
57
325
1.85
4.23
6.0
4.8
—
—
—
0
0
21
79
2.73
4.21
2.9
2.6
—
—
—
0
0
25
103
2.50
4.20
1.6
1.2
—
—
—
0
0
9
13
7.03
4.18
3.4
1.2
—
—
—
0
0
13
30
4.42
4.15
1.2
1.1
—
—
—
0
0
21
80
2.70
4.11
3.9
1.1
—
—
—
0
0
51
285
1.88
4.03
4.6
2.9
3.37
5.29
e9/l
1.33
46
226
7
7
10.12
4.02
1.7
1.4
—
—
—
0
0
22
88
2.57
3.93
8.2
1.8
53.99
61.79
%
0.77
22
88
14
43
3.32
3.93
5.4
3.2
—
—
—
0
0
26
113
2.37
3.92
1.4
2.8
35.04
33.11
umol/l
0.16
26
102
8
11
7.37
3.87
1.1
1.2
—
—
—
0
0
8
11
7.37
3.87
1.0
1.0
—
—
—
0
0
21
83
2.60
3.85
1.9
2.9
—
—
—
0
0
15
49
3.13
3.83
1.3
1.4
—
—
—
0
0
13
33
4.02
3.82
3.6
1.1
—
—
—
0
0
14
44
3.25
3.80
1.1
1.3
—
—
—
0
0
7
8
8.85
3.78
1.1
1.3
—
—
—
0
0
49
277
1.85
3.75
1.2
1.2
—
—
—
0
0
24
103
2.40
3.72
8.3
2.7
—
—
—
0
0
67
419
1.69
3.65
2.2
2.6
7.54
6.02
ug/l
0.22
58
373
149
1122
1.47
3.62
5.1
3.5
—
—
—
0
0
70
444
1.67
3.62
3.0
2.2
143.80
147.62
ug/g
0.05
61
348
13
35
3.79
3.61
1.4
1.2
—
—
—
0
0
118
849
1.51
3.58
1.4
1.2
0.71
1.39
u/ml
1.36
27
223
34
173
2.04
3.53
2.6
1.9
—
—
—
0
0
12
31
3.94
3.51
9.9
1.9
9.58
10.62
%
0.40
12
31
22
94
2.40
3.46
2.6
2.3
135.06
130.65
g/l
0.25
17
69
10
22
4.62
3.44
3.2
3.7
89.30
98.00
nmol/l
—
10
22
7
10
7.08
3.37
1.0
1.0
—
—
—
0
0
21
89
2.42
3.36
2.1
1.5
—
—
—
0
0
10
24
4.23
3.21
1.2
1.1
—
—
—
0
0
56
346
1.70
3.20
6.3
4.1
—
—
—
0
0
23
105
2.25
3.14
3.5
1.2
842.17
503.67
mg/l
0.41
23
98
10
25
4.06
3.10
1.4
1.4
—
—
—
0
0
6
8
7.57
3.06
7.7
5.4
—
—
—
0
0
8
16
5.06
3.06
2.0
1.4
—
—
—
0
0
21
94
2.29
3.00
3.3
1.1
4.13
3.88
mmol/l
0.15
21
87
25
122
2.10
2.92
1.6
1.5
208.14
270.35
ug/g
0.86
20
72
80
554
1.53
2.88
1.3
1.3
—
—
—
0
0
23
110
2.14
2.83
4.5
4.0
7.43
7.42
ph
0.28
23
92
8
18
4.50
2.80
1.1
1.1
—
—
—
0
0
205
1695
1.36
2.77
4.6
3.6
5.50
5.80
ph
—
5
99
5
6
8.40
2.75
18.0
6.5
4.34
7.15
mmol/l
—
5
6
6
187
0.31
2.71
1.3
1.4
—
—
—
0
0
8
19
4.26
2.69
3.0
1.5
—
—
—
0
0
35
199
1.82
2.68
1.1
1.2
—
—
—
0
0
22
107
2.11
2.61
1.0
1.2
—
—
—
0
0
7
15
4.72
2.60
1.9
1.4
—
—
—
0
0
5
7
7.20
2.55
1.6
1.3
—
—
—
0
0
202
1683
1.34
2.55
16.7
5.2
19.05
2.46
ug/l
4.37
192
1498
10
31
3.27
2.53
5.6
3.3
—
—
—
0
0
7
16
4.42
2.48
2.1
2.7
—
—
—
0
0
376
3441
1.38
2.47
63.7
20.6
329.04
332.06
g/l
7.99
376
3423
12
45
2.71
2.46
1.6
1.3
363954.29
239389.93
e6/l
—
7
30
13
52
2.54
2.37
1.6
1.6
60.58
64.40
%
—
8
42
10
33
3.07
2.37
1.1
1.0
—
—
—
0
0
18
85
2.16
2.31
1.3
1.3
60.00
61.29
mmol/l
0.05
13
75
8
23
3.52
2.28
2.8
2.0
—
—
—
0
0
24
128
1.92
2.25
1.3
1.2
—
—
—
0
0
455
4334
1.60
2.23
41.5
14.7
—
—
—
0
0
5
9
5.60
2.22
1.4
1.4
—
—
—
0
0
13
55
2.40
2.14
1.2
1.7
—
—
—
0
0
19
96
2.02
2.08
1.6
1.6
5.76
5.76
iu/l
—
8
28
11
44
2.53
2.02
1.0
1.2
—
—
—
0
0
403
4249
0.73
2.00
4.9
5.3
2.62
2.69
mmol/l
0.71
370
3883
5
11
4.58
1.94
2.0
1.7
—
—
—
0
0
121
974
1.32
1.86
1.7
1.7
413.44
6266100.11
pmol/l
0.50
105
798
391
4131
0.75
1.84
4.5
4.7
1.46
1.46
mmol/l
0.05
359
3769
48
331
1.50
1.80
1.6
1.4
—
—
—
0
0
7
23
3.07
1.80
1.6
1.3
—
—
—
0
0
8
30
2.69
1.73
1.4
1.2
—
—
—
0
0
36
236
1.57
1.70
2.6
2.5
—
—
—
0
0
32
204
1.61
1.70
2.1
2.9
—
—
—
0
0
12
55
2.21
1.68
2.8
2.0
89.70
89.58
%
0.03
12
55
85
660
1.35
1.67
1.3
1.3
4.81
12.59
u/ml
1.21
22
244
6
148
0.40
1.66
1.0
1.1
—
—
—
0
0
6
19
3.18
1.66
1.7
1.8
0.99
0.81
nmol/l
—
6
14
10
41
2.47
1.65
1.0
1.2
—
—
—
0
0
12
56
2.17
1.62
1.1
1.1
—
—
—
0
0
138
1151
1.28
1.61
6.8
4.2
0.00
0.00
estimate
-0.00
65
365
21
122
1.75
1.57
4.5
4.9
—
—
—
0
0
396
4157
0.76
1.56
4.6
4.7
4.60
4.57
mmol/l
0.18
368
3822
12
58
2.10
1.50
1.2
1.3
0.53
0.59
nmol/l
0.35
12
52
7
28
2.52
1.45
2.4
4.2
—
—
—
0
0
11
52
2.14
1.45
1.3
1.3
—
—
nmol/l
—
0
0
13
66
2.00
1.44
1.4
2.9
—
—
—
0
0
5
16
3.15
1.44
1.2
1.1
—
—
—
0
0
5
16
3.15
1.44
1.0
1.2
—
—
—
0
0
78
613
1.32
1.42
1.2
1.2
—
—
—
0
0
11
53
2.10
1.39
1.5
6.9
5.69
6.65
mmol/l
1.43
11
42
115
955
1.27
1.39
5.9
4.2
1.01
1.02
kg/l
0.71
24
133
11
55
2.02
1.28
1.3
1.3
—
—
—
0
0
8
36
2.24
1.24
1.3
1.1
—
—
—
0
0
119
1009
1.24
1.20
5.3
3.8
—
—
—
0
0
13
73
1.80
1.12
1.5
1.1
—
—
—
0
0
7
31
2.28
1.10
1.3
1.1
—
—
—
0
0
8
41
1.97
1.09
3.5
2.5
—
—
—
0
0
7
32
2.20
1.08
2.6
3.8
—
—
—
0
0
382
3986
0.82
1.07
4.3
4.2
1.48
1.28
mmol/l
4.30
349
3618
337
3178
1.19
1.02
4.8
3.8
14.96
14.93
pmol/l
0.06
317
2844
102
1191
0.82
1.02
1.7
1.7
1.63
1.34
mmol/l
2.23
92
984
39
292
1.36
1.01
3.8
2.8
—
—
—
0
0
16
99
1.64
1.01
7.2
3.9
27.87
30.18
mg/l
0.11
11
59
5
23
2.19
0.98
1.2
1.2
112.60
177.33
mmol/24h
—
5
23
6
27
2.24
0.93
1.5
1.4
73.00
76.22
umol/l
—
6
27
17
255
0.65
0.93
1.4
1.2
—
—
—
0
0
113
979
1.20
0.92
4.5
3.1
1.71
0.74
ug/l
2.10
93
667
16
103
1.57
0.88
1.4
1.3
—
—
—
0
0
6
111
0.53
0.84
2.3
1.9
43.83
42.49
nmol/l
—
6
104
10
58
1.74
0.80
1.0
1.3
4.40
4.68
u/ml
—
5
22
9
54
1.68
0.75
1.6
1.4
56.12
46.39
mu/l
—
9
49
7
119
0.58
0.68
3.3
1.6
—
—
—
0
0
18
128
1.42
0.66
1.1
1.1
—
—
—
0
0
81
704
1.18
0.66
1.4
1.3
29.80
39.41
iu/ml
0.24
23
229
34
421
0.79
0.62
1.4
1.6
—
—
—
0
0
8
51
1.58
0.60
1.1
1.2
—
—
—
0
0
8
51
1.58
0.60
1.1
1.5
550.25
260.98
pmol/l
—
8
46
5
89
0.56
0.56
2.2
1.5
—
—
—
0
0
12
82
1.47
0.55
1.7
1.5
—
—
—
0
0
57
491
1.18
0.53
1.6
1.3
—
—
—
0
0
9
65
1.39
0.51
1.6
2.9
—
—
—
0
0
7
46
1.53
0.48
1.4
1.3
—
—
—
0
0
18
233
0.76
0.48
1.4
1.2
52.00
120.58
iu/ml
—
5
86
5
32
1.57
0.42
1.0
1.4
0.92
1.19
promille
—
5
26
27
223
1.22
0.40
5.3
3.8
—
—
—
0
0
6
44
1.37
0.34
1.3
1.1
—
—
—
0
0
138
1464
0.92
0.34
4.9
3.8
16.19
8.71
mg/mmol
0.76
95
915
32
275
1.17
0.33
2.5
2.6
—
16.07
—
0
15
393
3857
1.09
0.31
5.5
4.7
1.91
1.97
mu/l
0.36
369
3483
419
4137
1.08
0.23
5.4
4.9
6.07
6.04
mmol/l
0.22
388
3751
0
10
0.00
0.21
0.0
2.1
—
14.19
—
0
10
8
105
0.76
0.21
1.1
1.1
—
—
—
0
0
0
14
0.00
0.20
0.0
1.3
—
0.37
—
0
7
12
144
0.83
0.20
11.4
11.4
—
—
—
0
0
28
251
1.12
0.19
1.6
1.4
—
—
—
0
0
6
52
1.16
0.19
1.2
1.1
—
—
—
0
0
6
53
1.13
0.18
1.2
1.1
—
—
—
0
0
35
382
0.91
0.17
8.0
3.4
—
—
—
0
0
148
1434
1.05
0.15
4.2
3.1
6.26
7.36
mmol/l
3.26
133
1188
11
129
0.85
0.15
3.4
2.4
164.40
81.95
ug/min
—
6
73
394
3975
0.96
0.12
6.5
6.2
40.93
40.35
mmol/mol
0.58
378
3668
137
1387
0.98
0.04
6.2
3.2
4208.79
179.57
mg/l
2.98
99
897
39
383
1.02
0.01
2.0
1.5
—
—
—
0
0
16
155
1.03
0.00
1.6
1.6
—
—
—
0
0
20
196
1.02
0.00
4.0
4.5
—
—
—
0
0
11
109
1.01
0.00
5.5
2.3
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
17.97
—
0
7
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.0
—
—
—
0
0

Mortality – FinRegistry

↥

Association

Association between endpoint OSTEON_DRUGS and mortality.

Females

Parameter HR [95% CI] p-value
OSTEON_DRUGS 6.288 [4.04, 9.8] < 0.001
Birth year 0.993 [0.98, 1.0] 0.139

During the follow-up period (1.1.1998 — 31.12.2019), 259 out of 709 females with OSTEON_DRUGS died.

Males

Parameter HR [95% CI] p-value
OSTEON_DRUGS 7.082 [4.47, 11.23] < 0.001
Birth year 0.985 [0.97, 1.0] 0.005

During the follow-up period (1.1.1998 — 31.12.2019), 330 out of 697 males with OSTEON_DRUGS died.

Mortality risk

Mortality risk for people of age

years, who have OSTEON_DRUGS.

N-year risk Females Males
1 0.545% 1.567%
5 3.374% 8.081%
10 8.458% 18.232%
15 15.072% 31.532%
20 25.297% 48.531%

Relationships between endpoints

↥

Index endpoint: OSTEON_DRUGS – Osteonecrosis due to drugs

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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