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Osteonecrosis due to drugs

EFO Endpoint Browser PheWeb

OSTEON_DRUGS

Endpoint definition

↥

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — M87.1#

1 out of 7 registries used, show all original rules.

403

4. Check minimum number of events

None

403

5. Include endpoints

None

403

6. Filter based on genotype QC (FinnGen only)

403

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy
C
First used in FinnGen datafreeze
DF5

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 1822 909 908
Only index persons 1748 891 857
Unadjusted period prevalence (%)
Whole population 0.03 0.03 0.03
Only index persons 0.03 0.03 0.03
Median age at first event (years)
Whole population 67.96 67.79 68.14
Only index persons 68.30 68.00 68.61

-FinnGen-

Key figures

All Female Male
Number of individuals 403 198 205
Unadjusted period prevalence (%) 0.08 0.07 0.09
Median age at first event (years) 69.87 69.61 70.12

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
370
Matched controls
3701
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
M87.1
ICD-10 Finland
Osteonecrosis due to drugs
+∞
323.0
370
*
M05BX04
ATC
denosumab; parenteral
48.0
167.0
208
96
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
13.6
105.7
299
873
H02AB02
ATC
dexamethasone; systemic
17.1
105.6
188
210
C79.5
ICD-10 Finland
Secondary malignant neoplasm of bone and bone marrow
50.9
91.0
109
30
ECB20
NOMESCO Finland
Oral alveoplasty
76.0
82.5
92
16
SAA03
NOMESCO Finland
Extended examination of mouth
8.7
78.4
271
887
WF049
NOMESCO Finland
Radiotherapy of metastasis
27.2
76.9
108
55
WD105
NOMESCO Finland
Cystostatic therapy of methastized malignancy
22.7
76.9
115
72
A03FA01
ATC
metoclopramide; systemic, rectal
8.1
70.2
203
480
N02AA05
ATC
oxycodone; systemic
8.8
68.7
178
352
EB1BI
NOMESCO Finland
Cone beam imaging of teeth and jaws (1–2 quarters)
67.9
66.9
76
14
WZC00
NOMESCO Finland
Planning of intervention or health care consultation
7.0
65.4
250
849
163
Kela drug reimbursment
Abiraterone and enzalutamide
78.0
62.9
70
11
C79.8
ICD-10 Finland
Secondary malignant neoplasm of other specified sites
17.9
50.5
81
57
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
5.4
49.8
254
1070
WD305
NOMESCO Finland
Simple therapy of methastized malignancy with biomodifiers
37.6
49.6
63
20
A04AA02
ATC
granisetron; systemic, transdermal
10.6
47.6
99
123
JN4BD
NOMESCO Finland
Extensive body CT
7.2
47.5
133
268
L02BB04
ATC
enzalutamide; oral
62.9
47.0
54
10
ZX120
NOMESCO Finland
Intravenous
7.6
44.1
115
206
ZX112
NOMESCO Finland
Subcutaneous
20.5
43.0
65
38
WD205
NOMESCO Finland
Therapy of methastized malignancy with hormones
57.5
42.9
50
10
116
Kela drug reimbursment
Prostate cancer
9.7
42.3
92
122
352
Kela drug reimbursment
Abiraterone and enzalutamide
74.7
41.1
46
7
L02BX03
ATC
abiraterone; oral
65.3
40.3
46
8
L02BB03
ATC
bicalutamide; oral
16.6
39.1
64
46
L03AA02
ATC
filgrastim; parenteral
16.0
37.4
62
46
WD225
NOMESCO Finland
Demanding therapy of methastized malignancy with hormones
34.2
37.1
48
16
Z51.5
ICD-10 Finland
Palliative care
8.4
37.1
88
133
Y77
ICPC
Malignant neoplasm prostate
15.6
37.1
62
47
A04AA01
ATC
ondansetron; systemic, rectal
7.9
36.4
90
145
A49.9
ICD-10 Finland
Bacterial infection, unspecified
6.0
35.8
112
249
L02BA03
ATC
fulvestrant; parenteral
105.5
35.4
38
*
192
Kela drug reimbursment
Fulvestrant
136.5
35.4
37
*
JN4AD
NOMESCO Finland
Body CT examination
7.1
35.2
94
169
R50.9
ICD-10 Finland
Fever, unspecified
5.5
34.9
119
293
L02BX02
ATC
degarelix; parenteral
33.9
34.8
45
15
NK6AN
NOMESCO Finland
Total body bone isotope imaging
13.8
34.6
61
52
EB1AI
NOMESCO Finland
Cone beam imaging of teeth and jaws (one quarter)
24.8
34.1
48
22
153
Kela drug reimbursment
Lenalidomid
62.0
34.0
39
7
L04AX04
ATC
lenalidomide; oral
70.2
33.7
38
6
C90.0
ICD-10 Finland
Multiple myeloma
28.3
33.2
45
18
K10.20
ICD-10 Finland
Osteomyelitis (neonatal) of jaw (acute)(chronic)(suppurative)
+∞
32.8
31
*
K10.25
ICD-10 Finland
Sequences of jawbones
352.5
32.4
32
*
EDW99
NOMESCO Finland
Other operation on mandible
340.0
31.3
31
*
8140/3-C61.9
ICD-O-3
Adenocarcinoma, NOS, of prostate gland
5.8
30.4
96
212
H02AB06
ATC
prednisolone; systemic
3.7
30.3
248
1322
EB1CI
NOMESCO Finland
Cone beam imaging of teeth and jaws (3-4 quarters)
62.1
29.7
34
6
C61
ICD-10 Finland
Malignant neoplasm of prostate
5.5
29.6
97
223
117
Kela drug reimbursment
Leukaemia and other malignant diseases of the blood and bone marrow, and malignant diseases of the lymphatic tissue
8.5
29.2
67
94
A79
ICPC
Malignancy NOS
24.7
28.5
40
18
K10.21
ICD-10 Finland
Osteoradionecrosis of jaw (acute)(chronic)(suppurative)
+∞
28.5
27
*
WZB00
NOMESCO Finland
Telephone receipt or other advice
3.8
28.5
159
613
GD1AA
NOMESCO Finland
Thorax X-ray examination
3.5
28.1
244
1326
L02AE02
ATC
leuprorelin; implant, parenteral
8.9
28.0
62
82
1501
Kela drug reimbursment
Palbociclib
104.6
27.1
29
*
WW500
NOMESCO Finland
Blood transfusion
9.7
26.7
56
67
XW000
NOMESCO Finland
Bone marrow biopsy
7.5
26.6
66
104
329
Kela drug reimbursment
Lenalidomide
100.7
26.0
28
*
5BA08
NOMESCO Finland
NA
36.0
26.0
33
10
WD125
NOMESCO Finland
Demanding cystostatic therapy of methastized malignancy
8.8
25.7
57
75
TPH04
NOMESCO Finland
Cathetrisation of vein
3.7
25.4
142
536
XX3DW
NOMESCO Finland
Time consuming IT work
5.1
25.3
88
213
M87.0
ICD-10 Finland
Idiopathic aseptic necrosis of bone
75.3
25.2
28
*
SXB00
NOMESCO Finland
Removeal of sutres from oral mucosa
7.0
25.1
65
109
394
Kela drug reimbursment
Palbociclib
96.8
25.0
27
*
L01XE33
ATC
[U] palbociclib; oral
267.2
25.0
25
*
A02BC02
ATC
pantoprazole; systemic
3.6
24.9
295
1934
N02AB03
ATC
fentanyl; nasal, sublingual, transdermal
8.8
24.6
54
70
ZX012
NOMESCO Finland
Radiotherapy with large shaped fields - isocentric therapy
6.7
23.4
62
107
WD505
NOMESCO Finland
Simple enzyme inhibitor or similar therapy of methastized malignancy
43.1
23.0
28
7
EBA10
NOMESCO Finland
Surgical removal of tooth
5.0
22.6
79
191
L02BG06
ATC
exemestane; oral
16.5
22.5
36
24
X76
ICPC
Malignant neoplasm breast female
13.5
22.4
39
32
9732/3-C42.1
ICD-O-3
Plasma cell myeloma of bone marrow
31.3
22.2
29
10
L03AA13
ATC
pegfilgrastim; parenteral
8.7
21.8
48
62
WZC10
NOMESCO Finland
Extensive specialist consultion with written report
6.7
21.8
58
100
115
Kela drug reimbursment
Breast cancer
5.2
21.8
72
163
C03CA01
ATC
furosemide; systemic
3.1
21.6
163
751
J01EE01
ATC
sulfamethoxazole and trimethoprim; systemic
6.0
21.5
62
119
WF004
NOMESCO Finland
Palliative radiotherapy
13.6
21.4
37
30
L02BA01
ATC
tamoxifen; oral
8.3
20.7
47
64
M87.9
ICD-10 Finland
Osteonecrosis, unspecified
51.1
20.4
24
5
L02BG04
ATC
letrozole; oral
5.8
20.1
60
120
EDB00
NOMESCO Finland
Partial excision of mandible
+∞
20.0
19
*
Z94.8
ICD-10 Finland
Other transplanted organ and tissue status
77.5
19.9
22
*
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
4.4
19.6
76
203
EDA10
NOMESCO Finland
Biopsy of mandible
73.8
18.9
21
*
NE1AA
NOMESCO Finland
Pelvis X-ray examination
5.4
18.7
59
126
SPAT1256
SPAT
Intramuscular and subcutaneous injection
2.7
18.6
212
1230
NF1AA
NOMESCO Finland
Hip X-ray examination
4.4
18.3
71
189
AA3AI
NOMESCO Finland
Cone beam CT of facial bones
34.9
18.2
23
7
SAA02
NOMESCO Finland
Basic examination of mouth
2.7
18.0
262
1736
D70.82
ICD-10 Finland
Drug-induced neutropenia
13.4
18.0
31
25
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
3.6
17.8
92
315
K08.1
ICD-10 Finland
Loss of teeth due to accident, extraction or local periodontal disease
3.9
17.4
79
242
B01AB05
ATC
enoxaparin; parenteral
2.7
17.2
159
804
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
5.4
17.2
53
110
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
2.6
17.1
219
1327
A28
ICPC
Limited function/disability NOS
3.3
17.0
97
356
WZC30
NOMESCO Finland
Teaching
3.5
17.0
90
311
N02BE01
ATC
paracetamol; systemic, rectal
4.4
16.9
345
2797
YN7AD
NOMESCO Finland
CT examination of spine for dose design of radiotherapy
66.5
16.9
19
*
DM1QA
NOMESCO Finland
Paranasal sinuses X-ray examination in one projection
6.0
16.6
47
88
N03AX16
ATC
pregabalin; oral
2.9
16.5
124
549
M05BA06
ATC
ibandronic acid; systemic
16.3
16.4
26
17
L95
ICPC
Osteoporosis
7.4
16.2
39
58
SXC05
NOMESCO Finland
Other oral or dental procedure
6.6
16.2
42
70
WX110
NOMESCO Finland
Local anesthesy
2.7
16.0
275
1929
ZX090
NOMESCO Finland
Other technic of radiotherapy
7.4
15.9
38
56
SAA01
NOMESCO Finland
Simple examination of mouth
2.7
15.9
279
1980
L04AA06
ATC
mycophenolic acid; systemic
12.5
15.8
28
24
WZC05
NOMESCO Finland
Specialty-specific consultation based on referral by dentist or doctor
5.2
15.6
50
108
N02AJ06
ATC
codeine and paracetamol; systemic
2.5
15.5
169
923
127
Kela drug reimbursment
Transplant complication
13.9
15.4
26
20
K04.5
ICD-10 Finland
Chronic apical periodontitis
2.7
15.4
129
605
YL1BD
NOMESCO Finland
Extensive CT examination of pelvis for dose design of radiotherapy
9.1
15.3
32
38
WW300
NOMESCO Finland
Transfer of autologic stem cells
47.1
15.2
18
*
1CD02
NOMESCO Finland
NA
17.4
15.0
23
14
WD515
NOMESCO Finland
Demanding therapy of malignancy with enzyme inhibitors and similar treatments
83.5
14.7
16
*
5BX04
NOMESCO Finland
NA
83.5
14.7
16
*
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
3.5
14.6
73
240
M05BA04
ATC
alendronic acid; oral
3.9
14.6
63
183
NE1BG
NOMESCO Finland
Pelvic, hip and femur MRI examination with high intensity magnet
7.8
14.4
33
46
WX2DD
NOMESCO Finland
Low-dose CT of skeleton in whole body
55.5
13.9
16
*
NA2AA
NOMESCO Finland
Thoracal spine X-ray examination without contrast
7.3
13.8
33
49
HAC20
NOMESCO Finland
Total mastectomy
5.8
13.8
39
73
WD115
NOMESCO Finland
Multiple cystostatic therapy of methastized malignancy
11.6
13.7
25
23
1XX32
NOMESCO Finland
NA
78.1
13.7
15
*
EFA20
NOMESCO Finland
Decortication of jaws
+∞
13.6
13
*
K10.28
ICD-10 Finland
Other inflammatory condition of the jaws
145.0
13.5
14
*
J05AB11
ATC
valaciclovir; oral
3.4
13.5
71
243
L01CA04
ATC
vinorelbine; systemic
15.8
13.3
21
14
NJ3DA
NOMESCO Finland
Long bones of extremities X-ray examination
23.5
13.0
18
8
EBA00
NOMESCO Finland
Extraction of tooth
2.4
13.0
151
829
K08.3
ICD-10 Finland
Retained dental root
4.1
12.8
52
143
WX290
NOMESCO Finland
Other blockade of nerve
2.3
12.8
167
974
NE1CG
NOMESCO Finland
Pelvic, hip and femur extensive MRI examination with high intensity magnet
9.8
12.7
25
27
FB1BD
NOMESCO Finland
Extensive CT examination of arteria pulmonalis
3.8
12.6
55
161
393
Kela drug reimbursment
Pomalidomide
134.3
12.5
13
*
WW409
NOMESCO Finland
Other aferesis
134.3
12.5
13
*
M87.3
ICD-10 Finland
Other secondary osteonecrosis
134.3
12.5
13
*
NA3BG
NOMESCO Finland
Lumbar spine MRI examination with high intensity magnet
3.6
12.4
58
180
SXC03
NOMESCO Finland
Other oral or dental procedure
16.6
12.3
19
12
AA1AA
NOMESCO Finland
Head X-ray examination
16.6
12.3
19
12
J01DB01
ATC
cefalexin; oral
2.7
12.2
313
2491
M05BB03
ATC
alendronic acid and colecalciferol; oral
7.2
12.2
29
43
TPH20
NOMESCO Finland
Insertion of central venous catheter through subclavian or brachiocephalic vein
6.8
12.1
30
47
L04AD01
ATC
ciclosporin; systemic
8.9
12.0
25
30
PJD52
NOMESCO Finland
Block dissection of axillary lymph nodes
5.2
12.0
37
77
YN7BD
NOMESCO Finland
Extensive CT examination of spine for dose design of radiotherapy
48.3
12.0
14
*
8500/3-C50.9
ICD-O-3
Infiltrating duct carcinoma, NOS, of breast, NOS
5.0
11.9
38
82
JN4CD
NOMESCO Finland
Very extensive body CT
5.7
11.8
34
65
L01BC06
ATC
capecitabine; oral
5.8
11.8
33
61
SAA04
NOMESCO Finland
Special inverstigation of mouth
4.7
11.7
40
93
L01EF01
ATC
palbociclib; oral
67.1
11.7
13
*
H02AB07
ATC
prednisone; oral
2.9
11.5
79
321
1507
Kela drug reimbursment
Pomalidomide
123.6
11.5
12
*
NK6QA
NOMESCO Finland
Measurement of bone density from tow or more locations with X-ray
3.8
11.4
49
142
NA1AA
NOMESCO Finland
Cervical spine X-ray examination without contrast
7.2
11.4
27
40
L04AX01
ATC
azathioprine; systemic
5.3
11.3
34
69
A06AD11
ATC
lactulose; oral
2.8
11.2
80
332
TNE25
NOMESCO Finland
Drill biopsy of bone marrow, pelvis
11.7
11.2
20
18
SPF00
NOMESCO Finland
Repatation of teeth prosthesis
6.6
11.2
28
45
J18.9
ICD-10 Finland
Pneumonia, unspecified
2.4
11.1
118
613
N03AX12
ATC
gabapentin; oral
2.8
11.0
79
330
ZXA00
NOMESCO Finland
Right side
2.3
11.0
133
735
J05AB01
ATC
aciclovir; systemic
2.6
11.0
94
435
J01FF01
ATC
clindamycin; systemic
2.3
10.9
126
680
K05.31
ICD-10 Finland
Periodontitis pronounced
3.1
10.8
64
235
WD325
NOMESCO Finland
Demanding therapy of methastized malignancy with biomodifiers
13.4
10.8
18
14
WD135
NOMESCO Finland
Demanding cystostatic therapy of methastized malignancy
13.4
10.8
18
14
YX9AD
NOMESCO Finland
Other CT eamination for dose design of radiotherapy
7.4
10.8
25
36
EBA15
NOMESCO Finland
Extraction of large number of teeth
4.8
10.7
35
78
XX7FT
NOMESCO Finland
Radioyttrium therapy with connected antibody
61.8
10.7
12
*
L03AA14
ATC
lipegfilgrastim; parenteral
10.5
10.6
20
20
A06AH03
ATC
naloxegol; oral
10.5
10.6
20
20
TEW99
NOMESCO Finland
Other minor procedure in surgery of teeth, jaws, mouth and pharynx
4.9
10.5
34
75
L04AX06
ATC
pomalidomide; oral
113.0
10.5
11
*
N02AX02
ATC
tramadol; systemic, rectal
2.1
10.5
184
1191
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
2.1
10.3
187
1223
SPF20
NOMESCO Finland
Temporary soling for filling
13.6
10.3
17
13
NFB30
NOMESCO Finland
Primary total prosthetic replacement of hip joint not using cement
3.8
10.2
44
128
WW200
NOMESCO Finland
Immunization
6.4
10.2
26
43
EB1AA
NOMESCO Finland
Tooth X-ray examination
2.1
10.2
213
1471
L04AA01
ATC
[U] ciclosporin; systemic
10.5
10.1
19
19
SPAT1254
SPAT
Administration of medicine
2.6
10.1
78
340
SPAT1230
SPAT
Aid fitting and borrowing and monitoring of use
2.5
10.0
86
397
EBA12
NOMESCO Finland
Complicated surgical removal of tooth
8.5
10.0
21
26
C50.41
ICD-10 Finland
Malignant tumor of the upper outer quadrant of the mammary gland, ductal tumor
4.2
10.0
38
99
L02AE03
ATC
goserelin; implant
17.3
9.9
15
9
318
Kela drug reimbursment
Teriparatide
12.7
9.9
17
14
C50.99
ICD-10 Finland
Breast, unspecified
5.7
9.7
27
50
J01MA12
ATC
levofloxacin; systemic
2.4
9.7
96
477
B03XA02
ATC
darbepoetin alfa; parenteral
7.5
9.6
22
31
R4110
NOMESCO Finland
Physiotherapy
2.2
9.6
121
672
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
3.1
9.5
55
200
Z01.2
ICD-10 Finland
Dental examination
2.1
9.5
156
969
ECA99
NOMESCO Finland
Other incision or excision of gingiva and alveolus
102.5
9.5
10
*
XX7AT
NOMESCO Finland
Radiation therapy with Radium-223
102.5
9.5
10
*
M81.9
ICD-10 Finland
Osteoporosis, unspecified
4.5
9.5
33
79
3054
Kela drug reimbursment
NA
30.9
9.5
12
*
1523
Kela drug reimbursment
NA
30.9
9.5
12
*
GA5AA
NOMESCO Finland
Rib X-ray examination
30.9
9.5
12
*
WW402
NOMESCO Finland
Leucoferesis
+∞
9.4
9
*
A07AA02
ATC
nystatin; oral
3.5
9.4
44
137
M05BA02
ATC
clodronic acid; systemic
22.4
9.4
13
6
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
2.5
9.4
80
365
C78.7
ICD-10 Finland
Secondary malignant neoplasm of liver and intrahepatic bile duct
6.6
9.2
23
37
NA7EA
NOMESCO Finland
Scoliosis X-ray examination
11.9
9.1
16
14
NA7DG
NOMESCO Finland
Spine and spinal cord very extensive MRI examination with high intensity magnet
11.9
9.1
16
14
M80.0
ICD-10 Finland
Postmenopausal osteoporosis with pathological fracture
6.8
9.1
22
34
ECW99
NOMESCO Finland
Other operation on gingiva or alveoli
37.7
9.1
11
*
-50
ICPC
Medication/prescr/renewal
4.5
9.0
31
73
WYA30
NOMESCO Finland
Preparations for expected poor cooperation
3.6
9.0
41
125
M05BA07
ATC
risedronic acid; oral
5.2
9.0
27
55
SPAT1255
SPAT
Intravenous administration of medicine
3.4
8.9
43
137
B03XA01
ATC
erythropoietin; parenteral
13.0
8.9
15
12
B01AB10
ATC
tinzaparin; parenteral
3.2
8.9
46
155
TPX10
NOMESCO Finland
Implantation of vascular injection port
5.1
8.9
27
56
WX199
NOMESCO Finland
Other local analgesia
5.4
8.6
25
49
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
2.6
8.6
64
272
SBB00
NOMESCO Finland
Fotograf of mouth and teeth
5.6
8.6
24
45
C50.4
ICD-10 Finland
Malignant neoplasm: Upper-outer quadrant of breast
20.6
8.5
12
6
H02AB09
ATC
hydrocortisone; systemic
5.5
8.5
24
46
M87.8
ICD-10 Finland
Other osteonecrosis
92.0
8.4
9
*
N05CF01
ATC
zopiclone; oral
2.0
8.3
133
808
WX892
NOMESCO Finland
Monitored bed care
3.1
8.3
46
160
HA1AE
NOMESCO Finland
Ultrasound examination of mammary glands
3.4
8.2
39
124
H05AA02
ATC
teriparatide; parenteral
12.1
8.1
14
12
ZX013
NOMESCO Finland
Radiotherapy with large shaped fields - SSD therapy
12.1
8.1
14
12
R06AE07
ATC
cetirizine; oral
1.9
8.1
163
1077
EDA00
NOMESCO Finland
Incision of mandible
17.7
8.1
12
7
NK6AQ
NOMESCO Finland
Whole body bone SPET with low dose CT
34.1
8.1
10
*
C91.0
ICD-10 Finland
Acute lymphoblastic leukaemia [ALL]
22.6
8.1
11
5
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
2.9
8.0
50
191
KE1AT
NOMESCO Finland
Biopsy of prostata with ultrasoudnguidance
3.3
8.0
39
126
N05BA04
ATC
oxazepam; oral
2.1
7.9
98
535
NF3AA
NOMESCO Finland
Femur X-ray examination
7.2
7.9
18
26
166
Kela drug reimbursment
Dalteparin and tinzaparin (treatment for more than 6 months)
9.7
7.8
15
16
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
2.3
7.8
77
377
K12.2
ICD-10 Finland
Cellulitis and abscess of mouth
15.4
7.8
12
8
J01MA14
ATC
moxifloxacin; systemic
2.8
7.8
49
189
1CX01
NOMESCO Finland
NA
45.9
7.7
9
*
EEW99
NOMESCO Finland
Other operation on maxilla
45.9
7.7
9
*
L02BG03
ATC
anastrozole; oral
6.9
7.7
18
27
WX408
NOMESCO Finland
General anesthesy, balanced
2.0
7.7
116
687
ZX108
NOMESCO Finland
Inhalation
12.2
7.6
13
11
J01MA02
ATC
ciprofloxacin; systemic
1.9
7.6
158
1050
D64.9
ICD-10 Finland
Anaemia, unspecified
2.6
7.6
57
243
AA1BD
NOMESCO Finland
Extensive CT of head and brain
5.2
7.5
22
44
SPAT1217
SPAT
Assessment of need for services (elderly/care support)
3.2
7.5
39
132
P01AB01
ATC
metronidazole; oral, rectal
1.9
7.5
153
1009
TPH90
NOMESCO Finland
Removal of fixed intravenous catheter
7.9
7.5
16
21
T86.0
ICD-10 Finland
Bone-marrow transplant rejection
81.6
7.4
8
*
SPAT1222
SPAT
Counselling/guidance promoting independent living
2.3
7.4
69
329
G03HA01
ATC
cyproterone; systemic
13.7
7.4
12
9
M80.4
ICD-10 Finland
Drug-induced osteoporosis with pathological fracture
13.7
7.4
12
9
X59
ICD-10 Finland
Exposure to unspecified factor
2.3
7.4
77
386
Z51.1
ICD-10 Finland
Chemotherapy session for neoplasm
8.6
7.4
15
18
EN1BD
NOMESCO Finland
Very extensive CT examination of mouth and soft tissues of neck
8.6
7.4
15
18
C50.81
ICD-10 Finland
Overall malignant tumor of the mammary gland, ductal tumor
8.6
7.4
15
18
WD405
NOMESCO Finland
Simple antiboidy therapy of methastized malignancy
5.4
7.4
21
41
NB1AA
NOMESCO Finland
Shoulder X-ray examination without contrast
3.1
7.4
41
144
EDB99
NOMESCO Finland
Other excision on mandible
+∞
7.3
7
*
M87
ICD-10 Finland
Osteonecrosis
+∞
7.3
7
*
K10.26
ICD-10 Finland
Periostitis of jaw (acute)(chronic)(suppurative)
+∞
7.3
7
*
L01AA03
ATC
melphalan; systemic
+∞
7.3
7
*
C77.8
ICD-10 Finland
Secondary and unspecified malignant neoplasm: Lymph nodes of multiple regions
16.1
7.3
11
7
JN3KE
NOMESCO Finland
Abdominal ultrasound with added contrast
16.1
7.3
11
7
DM1AA
NOMESCO Finland
Paranasal sinuses X-ray examination without contrast
4.2
7.2
26
65
EEA10
NOMESCO Finland
Biopsy of maxilla
30.6
7.2
9
*
NEA10
NOMESCO Finland
Exploration of soft tissue of pelvis, percutaneous
30.6
7.2
9
*
C77.5
ICD-10 Finland
Secondary and unspecified malignant neoplasm: Intrapelvic lymph nodes
30.6
7.2
9
*
AA1AD
NOMESCO Finland
CT of head and brain
2.0
7.1
107
628
YX9BD
NOMESCO Finland
Other extensive CT eamination for dose design of radiotherapy
10.3
7.1
13
13
ZXM00
NOMESCO Finland
Intraoperative use of ultrasonographic imaging
10.3
7.1
13
13
YL1AD
NOMESCO Finland
CT examination of pelvis for dose design of radiotherapy
7.2
7.1
16
23
J01CA04
ATC
amoxicillin; systemic
2.0
7.0
294
2451
PH1AE
NOMESCO Finland
Ultrasound examination of upper extremity veins
8.5
6.9
14
17
J15.9
ICD-10 Finland
Bacterial pneumonia, unspecified
2.7
6.8
44
173
ZXC40
NOMESCO Finland
Use of ultrasound
40.8
6.8
8
*
J01CE02
ATC
phenoxymethylpenicillin; oral
1.8
6.7
246
1934
SPA00
NOMESCO Finland
Changing form of teeth in prepation for prothetic work
3.5
6.7
30
91
L28
ICPC
Limited function/disability (L)
2.2
6.7
71
360
R60.0
ICD-10 Finland
Localized oedema
2.5
6.6
54
240
TPH07
NOMESCO Finland
Cathetrisation of artery
2.5
6.6
52
228
A29
ICPC
General symptom/complaint other
2.5
6.6
52
228
Z08.7
ICD-10 Finland
Follow-up examination after combined treatment for malignant neoplasm
12.5
6.6
11
9
C50.91
ICD-10 Finland
Malignant tumor in another specified localization in ductal mammary gland
8.9
6.6
13
15
M19.2
ICD-10 Finland
Other secondary arthrosis
8.9
6.6
13
15
SPE90
NOMESCO Finland
Other fitting and preparation of partial tooth prosthesis
5.2
6.6
19
38
WX404
NOMESCO Finland
Intravenous generell anesthesy
2.0
6.5
90
508
K02.1
ICD-10 Finland
Caries of dentine
1.8
6.5
197
1453
C50.90
ICD-10 Finland
Malignant tumor in other or unspecified location in mammary gland without histology
6.4
6.5
16
26
XX9AW
NOMESCO Finland
Production of copy from X-ray picture
4.2
6.5
23
57
ZXA05
NOMESCO Finland
Left side
1.9
6.4
110
673
NA2CG
NOMESCO Finland
Thoracal spine extensive MRI examination with high intensity magnet
14.6
6.4
10
7
ECA20
NOMESCO Finland
Biopsy of gingiva
8.4
6.4
13
16
NA3DG
NOMESCO Finland
Lumbar spine very extensive MRI examination with high intensity magnet
9.5
6.3
12
13
NK6CT
NOMESCO Finland
Bone biopsy with CT guidance
18.4
6.3
9
5
SPAT1088
SPAT
Blood transfusion
18.4
6.3
9
5
8520/3-C50.9
ICD-O-3
Lobular carcinoma, NOS, of breast, NOS
7.2
6.3
14
20
WZA90
NOMESCO Finland
Other doctors statement
2.0
6.3
93
540
Z52.89
ICD-10 Finland
Donor of other organ or tissue
+∞
6.3
6
*
WD215
NOMESCO Finland
Multiple therapy of methastized malignancy with hormones
+∞
6.3
6
*
EDC99
NOMESCO Finland
Other reconstructive operations on mandible
+∞
6.3
6
*
K05.30
ICD-10 Finland
Periodontitis complex
2.3
6.3
57
269
WX002
NOMESCO Finland
Sedation and analgesia
2.0
6.3
88
501
YNB10
NOMESCO Finland
Collection of stem cells for transplant
27.2
6.2
8
*
HA1AA
NOMESCO Finland
X-ray mammography
2.8
6.2
40
156
A01
ICPC
Pain general/multiple sites
2.9
6.2
36
132
A05AA02
ATC
ursodeoxycholic acid; oral
7.9
6.2
13
17
TKC20
NOMESCO Finland
Catheterisation of bladder
2.8
6.2
39
150
SPAT1137
SPAT
Taking care of patient’s/customer’s hygiene
3.1
6.1
32
110
WX725
NOMESCO Finland
Noninvasive ventilation
3.7
6.1
25
71
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
2.6
6.1
45
188
B02.9
ICD-10 Finland
Zoster without complication
3.2
6.1
30
99
XF600
NOMESCO Finland
Bloodpressure measurement
2.9
6.1
35
128
ZX080
NOMESCO Finland
Image guided radiotherapy
6.2
6.1
15
25
WX402
NOMESCO Finland
General anaesthesia
2.2
6.0
64
322
A46
ICD-10 Finland
Erysipelas
2.2
6.0
64
323
GD1BD
NOMESCO Finland
Thorax extensive CT-examination
2.9
6.0
35
129

LabWAS

↥
OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
265
1005
5.78
65.75
8.2
4.3
—
—
—
0
0
358
1794
9.92
63.50
27.2
6.8
1.2
1.2
mmol/l
0.56
316
1523
283
1215
5.46
58.03
12.1
3.3
2.3
2.4
mmol/l
0.62
268
1045
174
532
5.00
54.19
2.5
1.9
—
—
—
0
0
318
1573
5.84
52.65
12.5
4.6
33.0
35.2
g/l
9.27
308
1465
360
1992
8.57
51.79
39.5
9.1
3.8
4.1
e9/l
1.82
347
1748
266
1158
4.82
51.59
13.7
5.5
—
—
—
0
0
181
600
4.66
50.24
7.6
3.4
0.8
0.8
mmol/l
1.13
173
564
318
1651
5.39
47.32
20.1
5.9
1.2
1.2
mmol/l
1.17
312
1486
46
39
13.19
46.22
4.5
2.4
—
—
—
0
0
308
1640
4.72
42.16
16.0
5.8
24.2
27.2
%
4.62
302
1523
302
1597
4.56
41.43
15.8
5.7
2.4
2.8
%
3.56
295
1484
302
1603
4.53
41.06
16.4
6.0
8.9
8.8
%
0.31
296
1498
301
1613
4.42
39.88
15.6
5.6
59.8
57.5
%
2.09
294
1509
143
466
4.21
39.20
10.8
4.8
1.0
1.0
mmol/l
0.12
136
432
313
1738
4.59
39.10
15.2
5.5
1.5
1.9
e9/l
5.46
288
1526
308
1694
4.47
38.91
15.0
5.5
0.6
0.6
e9/l
0.18
282
1456
59
89
7.59
38.49
4.5
1.7
—
—
—
0
0
313
1756
4.50
38.07
16.1
5.7
0.2
0.2
e9/l
0.79
294
1540
307
1701
4.38
37.97
15.1
5.5
0.0
0.0
e9/l
3.22
281
1471
235
1091
3.77
37.93
16.5
3.8
7.4
7.4
ph
0.69
51
204
59
94
7.18
36.57
14.7
4.6
—
—
—
0
0
47
60
8.74
35.22
15.7
2.9
124.5
26.3
u/ml
2.69
47
60
108
313
4.35
34.24
9.2
6.3
10.1
9.6
mmol/l
0.29
103
298
24
10
25.46
33.63
2.6
1.8
55.1
63.8
ug/l
—
24
10
27
18
16.01
30.79
3.7
1.4
—
—
—
0
0
62
124
5.73
30.48
19.3
4.0
54.0
32.1
mg/l
0.65
53
96
62
124
5.73
30.48
19.3
4.0
92.4
95.8
mg/l
0.02
53
95
83
220
4.49
29.27
3.7
1.7
0.7
1.7
g/l
2.29
74
198
331
2119
4.15
29.00
11.2
4.8
6.7
6.8
mmol/l
0.19
323
1999
172
751
3.25
28.74
3.8
2.5
4.3
4.6
e6/l
0.12
160
659
62
131
5.41
28.65
14.2
1.9
7.6
10.5
g/l
4.68
49
111
41
57
7.89
28.51
1.7
1.3
—
—
—
0
0
269
1530
3.28
28.23
10.7
9.2
1.2
1.3
inr
0.37
75
430
26
20
13.83
27.37
3.3
2.1
—
—
—
0
0
144
580
3.31
27.32
2.8
2.3
12.8
12.9
umol/l
0.04
138
532
216
1103
3.07
27.05
5.5
3.2
599.2
114.6
e6/l
0.46
191
852
132
507
3.38
27.03
3.0
2.3
23.4
22.3
%
0.31
114
436
273
1603
3.18
26.37
8.6
4.0
—
—
—
0
0
110
382
3.59
26.34
2.5
1.7
—
—
—
0
0
134
529
3.30
26.12
2.8
2.3
2.2
2.3
g/l
1.03
126
488
43
70
6.76
25.91
3.3
1.7
—
—
—
0
0
161
713
3.10
25.72
4.9
2.8
538.6
555.7
mosm/kgh2o
0.40
150
602
63
149
4.83
25.45
2.0
2.0
2.0
4.0
ug/l
0.45
57
130
87
265
3.91
25.21
13.9
2.4
—
—
—
0
0
39
60
7.09
24.74
4.0
3.9
2.1
1.0
%
0.97
28
52
95
313
3.66
24.49
3.9
3.1
195.9
214.6
ng/l
0.17
87
287
85
265
3.80
23.73
4.7
4.4
1.1
0.5
%
2.06
29
73
226
1262
2.80
22.74
6.9
3.8
75.2
88.9
e6/l
0.20
194
909
28
32
9.33
22.68
16.5
2.6
235.3
63.9
u/ml
0.60
28
32
66
177
4.26
22.66
2.1
2.0
1.8
1.5
g/l
1.09
61
156
84
270
3.67
22.34
4.2
3.6
70.6
76.6
ng/l
0.26
74
241
206
1106
2.76
22.25
5.7
2.4
—
—
—
0
0
155
720
2.87
22.11
4.9
3.9
329.2
304.4
ng/l
0.06
128
586
203
1095
2.72
21.53
4.5
3.2
—
—
—
0
0
88
301
3.46
21.21
5.5
4.3
1.2
0.9
%
0.36
48
103
32
48
7.16
20.71
1.7
1.2
118.6
98.1
u/ml
—
7
7
335
2369
3.45
20.67
7.2
4.5
—
—
—
0
0
30
42
7.64
20.63
1.9
1.5
—
—
—
0
0
30
42
7.64
20.63
1.9
1.5
—
—
—
0
0
30
42
7.64
20.63
1.9
1.5
—
—
—
0
0
30
42
7.64
20.63
1.9
1.5
—
—
—
0
0
33
53
6.69
20.05
1.6
1.2
238.1
278.2
u/ml
0.23
22
30
25
29
9.12
19.98
2.7
2.4
—
—
—
0
0
147
695
2.76
19.92
6.3
3.1
2.5
2.5
mmol/l
0.89
133
610
91
331
3.26
19.78
4.8
2.7
72.2
71.1
e9/l
0.08
75
257
188
1009
2.62
19.69
4.9
3.1
0.4
0.5
e6/l
0.41
164
752
40
83
5.24
18.68
1.5
1.2
—
—
—
0
0
163
833
2.61
18.67
4.8
2.4
—
—
—
0
0
76
257
3.41
18.51
2.7
2.3
4.5
13.3
nmol/l
11.81
58
227
23
27
8.97
18.19
1.4
1.3
—
—
—
0
0
166
865
2.56
18.16
31.6
6.5
—
—
—
0
0
231
1404
2.51
18.11
3.6
2.2
83.1
77.5
nmol/l
2.42
216
1225
68
218
3.55
17.96
1.7
1.4
—
—
—
0
0
28
43
6.92
17.70
1.3
1.2
—
—
—
0
0
168
893
2.51
17.48
2.7
2.1
2.9
3.3
mg/l
1.14
153
770
18
16
11.73
17.21
4.2
2.2
10.8
13.9
%
—
8
8
86
327
3.07
17.17
1.5
1.5
—
—
—
0
0
43
102
4.60
17.14
4.1
3.6
—
—
—
0
0
83
317
3.04
16.40
2.9
1.9
360.1
371.3
nmol/l
0.17
78
293
76
280
3.11
15.96
5.7
4.4
0.1
0.2
%
0.28
45
92
128
621
2.56
15.92
4.8
1.4
2.1
2.6
g/l
1.49
101
359
174
975
2.38
15.74
5.0
3.0
—
—
—
0
0
20
25
8.37
15.02
2.8
2.1
432.6
700.9
e6/l
—
5
11
123
603
2.50
14.82
4.7
2.9
3.9
2.0
e6/l
0.90
77
331
218
1384
2.25
14.26
4.3
2.6
279.7
144.4
ug/l
5.83
204
1254
91
392
2.71
14.25
8.6
2.9
7.5
9.9
umol/l
0.40
82
347
83
342
2.80
14.15
8.5
3.3
1.8
2.0
mmol/l
0.23
67
271
81
330
2.82
14.11
2.0
1.5
—
—
—
0
0
70
264
3.00
14.03
5.0
4.5
0.4
0.1
%
0.45
34
77
18
23
8.15
13.25
1.7
2.8
32.7
45.6
%
—
7
8
183
1114
2.18
12.92
3.3
2.4
51.8
56.5
u/l
0.92
175
1022
19
27
7.34
12.81
4.4
2.2
0.9
1.0
e9/l
0.11
12
13
229
1527
2.16
12.72
27.7
9.6
0.0
0.0
e9/l
0.46
198
1255
26
52
5.28
12.59
1.1
1.1
—
—
—
0
0
23
41
5.89
12.56
4.0
3.5
61.8
55.0
%
0.46
14
31
136
742
2.26
12.54
3.0
1.8
1.2
1.3
mg/l
0.25
113
581
130
702
2.26
12.24
1.8
1.7
1018.6
1213.0
nmol/l
1.63
113
529
82
362
2.59
12.09
2.0
1.5
—
—
—
0
0
13
12
11.16
12.02
2.5
2.6
—
—
—
0
0
62
241
2.86
11.68
4.8
3.9
7.4
7.4
ph
—
7
25
27
60
4.75
11.60
1.1
1.1
—
—
—
0
0
73
311
2.65
11.54
12.4
8.3
—
—
—
0
0
389
3358
5.56
11.33
53.9
15.4
26.3
23.8
mg/l
0.91
370
2693
86
400
2.46
11.31
7.7
4.6
36.4
40.6
ug/l
0.05
75
345
18
28
6.68
11.18
1.1
1.0
—
—
—
0
0
23
46
5.24
11.13
1.6
1.3
—
—
—
0
0
130
732
2.15
10.83
8.0
4.8
—
—
—
0
0
87
420
2.37
10.48
2.0
1.7
—
—
—
0
0
203
1366
1.98
10.21
2.5
2.1
—
—
—
0
0
15
9
17.24
9.94
1.5
1.7
—
—
—
0
0
12
13
9.48
9.92
1.0
1.2
—
—
—
0
0
12
13
9.48
9.92
4.5
1.5
—
—
—
0
0
67
295
2.52
9.83
14.6
3.6
1.2
1.2
mmol/l
0.16
67
258
179
1166
1.96
9.78
4.3
3.2
2212.5
1283.5
ng/l
0.57
163
998
51
196
2.83
9.77
11.1
10.1
—
—
—
0
0
11
11
10.25
9.58
1.0
1.1
—
—
—
0
0
77
367
2.36
9.49
16.9
4.2
—
—
—
0
0
21
46
4.76
9.17
1.3
1.8
0.6
1.0
g/l
0.47
16
38
86
438
2.22
9.05
2.0
1.4
—
—
—
0
0
74
362
2.28
8.55
2.0
2.1
0.2
0.2
g/l
0.21
74
340
11
13
8.67
8.50
2.2
1.0
—
—
—
0
0
85
443
2.16
8.41
1.5
1.3
842.0
525.4
titre
0.56
20
104
85
447
2.14
8.20
9.1
7.6
1.8
1.2
mmol/l
0.63
71
364
25
69
3.80
8.14
1.3
1.2
76.3
17.5
u/l
1.72
25
59
12
8
15.41
7.76
3.7
2.0
—
—
—
0
0
12
18
6.84
7.64
1.2
1.6
—
—
—
0
0
14
25
5.77
7.59
1.1
1.2
—
—
—
0
0
24
68
3.69
7.54
3.5
2.7
—
—
—
0
0
20
50
4.16
7.43
1.4
1.1
—
—
—
0
0
28
90
3.27
7.28
2.1
1.5
21489.9
14816.7
e6/l
0.18
20
67
20
51
4.07
7.25
2.2
1.4
—
—
—
0
0
44
185
2.55
7.07
5.5
3.9
—
—
—
0
0
17
39
4.51
7.02
1.3
1.3
3341.3
1542.8
e6/l
0.29
12
28
19
48
4.10
6.97
5.1
4.1
—
—
—
0
0
25
78
3.35
6.82
1.6
1.2
—
—
—
0
0
13
25
5.34
6.53
1.2
1.2
—
—
—
0
0
14
29
4.97
6.50
4.5
1.1
—
—
—
0
0
11
18
6.25
6.46
2.2
2.2
524.2
903.8
u/ml
0.97
11
18
10
7
14.60
6.43
4.5
2.0
—
—
—
0
0
10
7
14.60
6.43
1.4
1.6
—
—
—
0
0
33
128
2.72
6.22
4.2
3.4
1.6
0.2
g/l
0.60
19
54
18
48
3.88
6.15
1.6
1.5
—
—
—
0
0
135
904
1.74
6.10
1.7
1.5
18.5
20.9
nmol/l
1.38
122
754
86
502
1.91
6.10
18.5
22.9
1.2
1.2
inr
0.04
27
68
20
58
3.58
6.09
4.0
1.2
—
—
—
0
0
21
63
3.46
6.08
2.4
2.4
—
—
—
0
0
199
1485
1.67
5.99
2.5
2.0
85.6
95.7
pmol/l
2.47
128
754
40
174
2.44
5.99
1.4
1.3
—
—
—
0
0
27
96
2.94
5.96
3.0
2.4
24.9
25.0
mmol/l
0.04
22
82
15
36
4.29
5.87
1.3
1.3
5782.8
41071.5
e6/l
—
9
22
127
853
1.71
5.61
1.8
1.3
—
—
—
0
0
12
25
4.92
5.53
3.8
1.1
—
—
—
0
0
36
156
2.44
5.44
1.4
1.6
—
—
—
0
0
302
2550
1.74
5.39
7.6
4.2
21.4
12.9
mm/h
8.00
292
2333
190
1432
1.62
5.29
4.8
3.9
38.7
60.1
ng/l
0.44
149
1069
20
65
3.19
5.14
4.5
3.1
54.5
58.9
%
0.64
20
65
12
27
4.55
5.07
1.4
1.1
—
—
—
0
0
133
926
1.65
5.04
7.9
2.6
339.1
8777.7
umol/l
4.83
126
786
69
1103
0.55
4.94
3.2
3.1
—
—
—
0
0
152
1099
1.62
4.94
2.6
2.1
144.7
278.3
u/l
1.12
145
1025
22
78
2.93
4.90
9.2
2.7
—
—
—
0
0
19
62
3.17
4.85
4.1
2.6
3.4
4.5
e9/l
1.44
19
62
18
57
3.26
4.82
1.8
2.8
—
—
—
0
0
20
68
3.04
4.78
1.9
1.4
—
—
—
0
0
213
1681
1.57
4.69
6.8
5.2
0.0
0.0
estimate
0.00
58
303
20
69
3.00
4.67
8.9
1.7
56.1
62.7
%
0.57
20
69
9
11
8.34
4.58
3.8
4.8
59.9
46.5
%
—
9
11
292
2487
1.63
4.57
5.2
4.2
—
—
—
0
0
19
65
3.02
4.50
3.5
1.1
4.2
3.9
mmol/l
0.15
19
60
30
131
2.39
4.48
6.8
2.2
21.9
21.6
s
0.13
30
121
213
1701
1.53
4.31
5.2
3.8
0.0
0.0
estimate
0.50
55
289
12
31
3.96
4.28
1.2
1.3
—
—
—
0
0
19
68
2.88
4.18
3.7
2.3
17.1
15.7
%
0.92
11
34
7
7
10.15
4.02
1.0
1.0
—
—
—
0
0
7
7
10.15
4.02
1.1
1.1
—
—
—
0
0
11
28
4.01
4.00
10.7
1.7
9.9
10.6
%
0.23
11
28
208
1671
1.51
3.98
5.1
3.8
0.0
0.0
estimate
0.00
51
306
15
48
3.21
3.97
2.7
1.9
33.3
33.1
pg
0.09
15
48
6
5
12.15
3.77
1.2
1.4
—
—
—
0
0
57
340
1.79
3.73
2.1
2.6
8.4
6.3
ug/l
0.27
49
300
8
12
6.77
3.69
2.0
1.3
—
—
—
0
0
8
12
6.77
3.69
3.6
1.2
—
—
—
0
0
47
265
1.88
3.67
6.8
4.5
—
—
—
0
0
145
1101
1.50
3.55
5.0
4.2
—
—
—
0
0
10
26
3.92
3.54
5.7
3.4
—
—
—
0
0
392
3716
3.01
3.53
74.7
22.6
243.9
243.4
e9/l
0.04
387
3617
6
6
10.12
3.51
2.0
1.0
—
—
—
0
0
12
36
3.40
3.50
1.7
1.3
—
—
—
0
0
12
36
3.40
3.50
1.2
1.5
—
—
—
0
0
12
36
3.40
3.50
5.6
3.5
—
—
—
0
0
23
100
2.38
3.50
1.3
1.2
—
—
—
0
0
42
232
1.90
3.50
4.5
2.7
3.4
4.2
e9/l
1.89
37
175
392
3718
2.99
3.48
74.5
22.6
4.0
4.5
e12/l
43.83
386
3602
392
3718
2.99
3.48
74.5
22.7
6.5
6.7
e9/l
0.83
387
3605
17
66
2.65
3.25
2.5
2.3
—
—
—
0
0
8
15
5.42
3.20
3.0
1.7
—
—
—
0
0
48
285
1.78
3.19
6.1
3.8
—
—
—
0
0
6
200
0.29
3.16
1.7
1.4
—
—
—
0
0
39
220
1.86
3.06
1.2
1.2
—
—
—
0
0
8
16
5.08
3.06
3.7
2.4
96.1
71.0
nmol/l
—
8
16
5
5
10.10
2.98
1.8
1.4
—
—
—
0
0
5
5
10.10
2.98
8.2
2.0
—
—
—
0
0
56
355
1.67
2.96
2.8
2.2
150.4
147.5
ug/g
0.03
48
278
328
2979
1.54
2.90
56.6
16.7
35.0
39.7
%
10.59
219
2005
7
13
5.46
2.88
2.1
2.8
—
—
—
0
0
119
901
1.46
2.86
5.1
3.6
—
—
—
0
0
5
6
8.42
2.75
1.0
1.0
—
—
—
0
0
19
85
2.30
2.75
5.0
2.8
7.4
7.4
ph
0.39
19
69
27
140
2.00
2.72
1.7
1.9
—
—
—
0
0
94
687
1.48
2.69
1.4
1.2
0.7
1.4
u/ml
1.14
21
177
17
73
2.39
2.69
1.6
1.5
5.8
6.5
iu/l
—
8
21
305
2751
1.45
2.59
67.0
20.3
328.8
332.2
g/l
7.92
305
2738
9
26
3.52
2.49
1.1
1.0
—
—
—
0
0
29
160
1.88
2.47
1.1
1.3
—
—
—
0
0
321
3431
0.68
2.34
4.8
5.3
2.6
2.7
mmol/l
0.37
292
3113
11
41
2.73
2.29
2.9
2.1
90.4
90.4
%
0.01
11
41
311
3333
0.71
2.16
4.4
4.7
1.4
1.5
mmol/l
0.32
285
3019
63
445
1.49
2.13
1.3
1.3
—
—
—
0
0
11
43
2.60
2.11
1.1
1.8
—
—
—
0
0
7
20
3.54
2.06
1.4
1.2
—
—
—
0
0
5
148
0.33
2.04
1.4
1.4
—
—
—
0
0
28
163
1.77
2.04
2.0
2.8
—
—
—
0
0
7
21
3.37
1.97
1.6
1.3
—
—
—
0
0
11
45
2.48
1.94
1.1
1.2
—
—
—
0
0
369
3509
1.61
1.93
42.2
14.6
—
—
—
0
0
315
3351
0.73
1.85
4.5
4.7
4.6
4.6
mmol/l
0.26
292
3063
6
17
3.57
1.84
1.2
1.1
—
—
—
0
0
6
17
3.57
1.84
1.3
1.1
—
—
—
0
0
161
1360
1.31
1.84
17.2
5.1
22.3
2.4
ug/l
4.08
153
1203
5
12
4.20
1.83
1.2
1.2
—
—
—
0
0
12
53
2.30
1.82
1.3
3.1
—
—
—
0
0
9
36
2.53
1.75
1.0
1.1
—
—
—
0
0
6
19
3.19
1.66
1.7
1.5
—
—
—
0
0
5
14
3.60
1.62
1.0
1.2
—
—
—
0
0
6
20
3.03
1.58
3.0
2.0
—
—
—
0
0
302
3214
0.76
1.57
4.3
4.2
1.5
1.3
mmol/l
4.53
277
2899
10
44
2.31
1.54
1.3
1.4
—
—
nmol/l
—
0
0
16
88
1.85
1.43
1.0
1.1
—
—
—
0
0
76
949
0.75
1.41
1.8
1.6
1.6
1.4
mmol/l
1.63
70
774
14
74
1.92
1.40
6.8
4.1
21.4
32.5
mg/l
—
9
46
5
117
0.42
1.27
1.0
1.1
—
—
—
0
0
38
272
1.44
1.25
1.6
1.4
—
—
—
0
0
6
25
2.42
1.25
1.3
1.2
—
—
—
0
0
6
25
2.42
1.25
2.7
4.1
—
—
—
0
0
9
45
2.02
1.24
1.7
7.8
5.6
6.3
mmol/l
—
9
36
10
49
2.07
1.23
1.3
1.4
0.5
0.6
nmol/l
—
10
44
94
781
1.27
1.17
1.7
1.8
422.2
438.4
pmol/l
0.22
85
640
7
31
2.28
1.11
3.6
2.8
—
—
—
0
0
9
46
1.98
1.04
1.3
1.4
—
—
—
0
0
7
35
2.02
1.00
1.4
1.4
—
—
—
0
0
107
919
1.22
0.99
6.7
4.1
0.0
0.0
estimate
0.00
52
292
5
23
2.19
0.98
2.8
4.4
—
—
—
0
0
27
192
1.44
0.95
2.4
2.5
—
—
—
0
0
7
37
1.91
0.94
1.0
1.2
—
—
—
0
0
93
792
1.23
0.94
4.6
3.1
1.7
0.7
ug/l
1.61
73
519
93
793
1.22
0.93
4.6
3.7
—
—
—
0
0
11
64
1.74
0.87
1.7
1.4
—
—
—
0
0
6
31
1.95
0.84
1.3
1.1
—
—
—
0
0
59
486
1.25
0.81
1.2
1.2
—
—
—
0
0
6
33
1.83
0.79
1.3
1.2
—
—
—
0
0
86
748
1.19
0.71
5.8
4.2
1.0
1.0
kg/l
0.65
16
107
30
231
1.32
0.70
3.2
2.7
—
—
—
0
0
310
3214
0.85
0.70
6.2
6.3
40.6
40.5
mmol/mol
0.08
297
2952
15
102
1.49
0.68
4.9
5.2
—
—
—
0
0
15
104
1.46
0.63
1.1
1.1
—
—
—
0
0
10
63
1.60
0.62
1.5
1.1
—
—
—
0
0
14
195
0.71
0.57
1.4
1.2
—
—
—
0
0
108
1191
0.87
0.57
5.1
4.0
19.1
8.7
mg/mmol
0.85
73
734
5
89
0.56
0.56
1.2
1.1
—
—
—
0
0
8
55
1.46
0.56
1.6
3.1
—
—
—
0
0
61
527
1.19
0.56
1.3
1.3
5.1
13.3
u/ml
0.99
17
198
28
222
1.28
0.55
2.6
2.6
—
10.9
—
0
8
47
397
1.21
0.54
1.6
1.3
—
—
—
0
0
6
39
1.55
0.53
1.2
1.3
—
—
—
0
0
266
2549
1.13
0.53
4.8
3.7
14.9
14.9
pmol/l
0.02
248
2262
6
40
1.51
0.52
1.2
1.1
—
—
—
0
0
6
40
1.51
0.52
1.2
1.1
—
—
—
0
0
7
48
1.47
0.47
1.7
1.3
70.5
50.2
mu/l
—
7
43
6
91
0.65
0.43
2.3
1.8
43.8
42.4
nmol/l
—
6
84
11
79
1.40
0.41
1.3
1.3
—
—
—
0
0
0
18
0.00
0.40
0.0
1.0
—
—
—
0
0
28
332
0.83
0.38
1.4
1.6
—
—
—
0
0
16
125
1.29
0.37
1.6
1.6
—
—
—
0
0
6
42
1.43
0.35
1.2
1.4
—
—
—
0
0
9
116
0.77
0.28
12.6
10.9
—
—
—
0
0
106
1124
0.92
0.27
6.1
3.2
3955.6
156.1
mg/l
2.29
76
714
15
180
0.83
0.24
1.2
1.2
52.0
136.1
iu/ml
—
5
65
23
202
1.15
0.20
1.6
1.4
—
—
—
0
0
0
14
0.00
0.20
0.0
1.4
—
—
—
0
0
27
302
0.89
0.20
2.1
1.5
—
—
—
0
0
306
3093
0.96
0.12
5.6
4.6
1.9
2.0
mu/l
0.34
286
2771
20
181
1.11
0.12
4.0
4.1
—
—
—
0
0
58
553
1.06
0.12
1.5
1.3
36.8
37.8
iu/ml
0.02
17
178
17
154
1.11
0.10
4.2
4.5
—
—
—
0
0
119
1164
1.03
0.08
4.3
3.1
6.4
7.3
mmol/l
2.21
107
948
28
292
0.96
0.04
7.5
3.4
—
—
—
0
0
332
3334
0.98
0.04
5.1
4.9
6.0
6.1
mmol/l
0.21
304
3016
0
6
0.00
0.00
0.0
1.8
—
14.4
—
0
6
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
19.2
—
0
6
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.6
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.6
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
7
78
0.90
0.00
2.0
2.2
—
—
—
0
0

Mortality – FinRegistry

↥

Association

Association between endpoint OSTEON_DRUGS and mortality.

Females

Parameter HR [95% CI] p-value
OSTEON_DRUGS 6.288 [4.04, 9.8] < 0.001
Birth year 0.993 [0.98, 1.0] 0.139

During the follow-up period (1.1.1998 — 31.12.2019), 259 out of 709 females with OSTEON_DRUGS died.

Males

Parameter HR [95% CI] p-value
OSTEON_DRUGS 7.082 [4.47, 11.23] < 0.001
Birth year 0.985 [0.97, 1.0] 0.005

During the follow-up period (1.1.1998 — 31.12.2019), 330 out of 697 males with OSTEON_DRUGS died.

Mortality risk

Mortality risk for people of age

years, who have OSTEON_DRUGS.

N-year risk Females Males
1 0.545% 1.567%
5 3.374% 8.081%
10 8.458% 18.232%
15 15.072% 31.532%
20 25.297% 48.531%

Relationships between endpoints

↥

Index endpoint: OSTEON_DRUGS – Osteonecrosis due to drugs

GWS hits: 1

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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