Congenital malformations of eyelid, lacrimal apparatus and orbit

Q17_CONGEN_MALFO_EYELID_LACRIMAL_APPARA_ORBIT

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 Q10
  • Cause of death: ICD-10 Q10

2 out of 7 registries used, show all original rules.

336

4. Check minimum number of events

None

336

5. Include endpoints

None

336

6. Filter based on genotype QC (FinnGen only)

336

Control definitions (FinnGen only)

Control exclude
Q17_CONGEN_MALFO_EYE_EAR_FACE_NECK

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF4
Parent code in ICD-10
Q1
Name in latin
Malformationes congenitae palpebrarum, apparatus lacrimalis et orbitae

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 12033 5863 6168
Only index persons 7548 3712 3836
Unadjusted period prevalence (%)
Whole population 0.17 0.17 0.17
Only index persons 0.14 0.14 0.15
Median age at first event (years)
Whole population 1.30 1.32 1.26
Only index persons 1.36 1.40 1.32

-FinnGen-

Key figures

All Female Male
Number of individuals 336 199 137
Unadjusted period prevalence (%) 0.06 0.07 0.06
Median age at first event (years) 2.98 1.85 4.62

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
304
Matched controls
3048
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
Q10.5
ICD-10 Finland
Congenital stenosis and stricture of lacrimal duct
+∞
183.4
157
*
Q10.0
ICD-10 Finland
Congenital ptosis
+∞
132.1
117
*
TCC10
NOMESCO Finland
Probing of lacrimal canaliculus/duct
550.4
86.7
82
*
H02.4
ICD-10 Finland
Ptosis of eyelid
62.3
45.3
52
10
CBJ40
NOMESCO Finland
Resection of levator muscle of eyelid
178.0
31.3
32
*
H04.5
ICD-10 Finland
Stenosis and insufficiency of lacrimal passages
35.7
27.5
35
11
CCA20
NOMESCO Finland
Incision of lacrimal punctum or canaliculus
76.6
25.3
28
*
CBJ10
NOMESCO Finland
Fascia plate sling or synthetic material for ptosis correction
+∞
20.0
19
*
74482
ICD-8 Finland
Congenital anomalies of eye, Ptosis
+∞
17.9
17
*
Q10.30
ICD-10 Finland
Other congenital malformations of eyelid
+∞
16.8
16
*
ZXA10
NOMESCO Finland
Bilateral
3.6
14.4
73
248
CBJ30
NOMESCO Finland
Plastic repair of levator aponeurosis of eyelid
146.2
13.6
14
*
Q10.2
ICD-10 Finland
Congenital entropion
+∞
10.5
10
*
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
2.6
9.6
79
362
XCK10
NOMESCO Finland
Photography of fundus of eye
4.4
8.6
30
73
CBJ99
NOMESCO Finland
Other operation for ptosis
+∞
8.4
8
*
TCC30
NOMESCO Finland
Intubation of lacrimal canaliculus/duct
82.0
7.4
8
*
7436B
ICD-9 Finland
Congenital anomalies of eyelids, lachrymal system and orbit[PTOSIS CONGENITA]
+∞
7.3
7
*
3242
FHL
Levator resection
+∞
7.3
7
*
XCC00
NOMESCO Finland
Investigative irrigation of lacrimal passages
30.8
7.2
9
*
WX400
NOMESCO Finland
Inhalation anesthesy
3.7
6.9
29
84
ZXA00
NOMESCO Finland
Right side
2.5
6.8
57
260
H02.3
ICD-10 Finland
Blepharochalasis
7.4
6.8
15
21
Q10.1
ICD-10 Finland
Congenital ectropion
+∞
6.3
6
*
CCD50
NOMESCO Finland
Dacryocystorhinostomy with insertion of tube
+∞
6.3
6
*
S01AA01
ATC
chloramphenicol; ophthalmic (antibiotics)
4.2
6.2
22
55
H53.0
ICD-10 Finland
Amblyopia ex anopsia
5.8
6.1
16
29
ZXA05
NOMESCO Finland
Left side
2.4
6.0
53
249

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
31
152
2.14
3.59
1.7
2.1
11.9
12.8
iu/l
0.10
26
120
294
2664
1.83
3.35
11.7
11.3
24.9
21.5
mg/l
0.73
219
1934
29
156
1.94
2.66
1.9
2.2
6.6
6.9
u/l
0.08
23
122
30
166
1.89
2.54
1.4
2.1
10.1
12.6
nmol/l
0.61
25
147
39
241
1.70
2.32
1.6
1.6
932.9
1135.6
nmol/l
1.04
31
178
37
229
1.69
2.19
1.4
1.4
262.1
361.3
u/ml
0.22
31
214
296
2767
1.58
2.00
11.5
9.0
—
—
—
0
0
113
918
1.35
1.78
4.0
4.5
69.3
92.2
e6/l
0.16
85
619
221
1981
1.34
1.74
3.4
3.4
14.7
14.5
pmol/l
0.53
201
1789
69
519
1.41
1.73
2.7
2.9
7.5
8.2
e6/l
0.14
60
456
90
710
1.36
1.70
1.8
1.9
—
—
—
0
0
80
620
1.38
1.68
2.5
2.6
48.9
57.6
u/l
1.62
74
563
86
676
1.37
1.66
1.9
1.6
96.9
96.5
pmol/l
0.02
48
353
8
32
2.53
1.60
1.0
1.0
—
—
—
0
0
264
2443
1.37
1.60
13.3
12.6
3.9
3.9
mmol/l
0.47
258
2364
43
300
1.50
1.59
2.2
2.3
2904.1
3186.6
u/l
0.03
13
93
6
20
3.03
1.58
2.2
1.8
—
—
—
0
0
35
234
1.55
1.57
1.4
1.6
—
—
—
0
0
89
712
1.34
1.53
3.2
3.7
—
—
—
0
0
23
139
1.70
1.52
1.3
1.2
—
—
—
0
0
41
286
1.49
1.52
2.7
2.8
18.8
23.9
%
1.71
34
262
22
132
1.71
1.50
2.6
2.0
—
—
—
0
0
32
212
1.56
1.50
1.1
1.2
—
—
—
0
0
88
709
1.33
1.44
3.4
3.8
0.4
0.3
e6/l
0.13
69
529
124
1048
1.29
1.43
5.4
7.0
17.6
18.5
umol/l
0.08
114
978
94
767
1.31
1.40
3.6
3.9
8.1
129.4
e6/l
0.82
76
587
285
2687
1.40
1.40
13.3
13.0
39.4
40.1
%
0.73
228
2271
262
2441
1.33
1.37
13.5
12.6
139.5
139.5
mmol/l
0.17
256
2367
64
495
1.36
1.37
6.0
4.3
—
—
—
0
0
21
128
1.68
1.36
4.0
7.7
21.8
22.8
s
0.55
21
121
81
653
1.32
1.31
6.8
5.5
1.1
1.1
inr
0.03
34
225
71
564
1.33
1.28
2.5
2.9
23.9
30.2
ng/l
0.23
35
281
119
1018
1.26
1.21
9.0
10.9
1.2
1.2
mmol/l
0.88
109
949
15
90
1.70
1.05
3.1
2.5
—
—
—
0
0
9
46
1.98
1.04
2.6
15.3
1.4
1.5
%
—
9
41
180
1632
1.22
1.04
6.2
6.2
91.8
93.3
u/l
0.11
175
1534
40
301
1.37
1.03
11.1
10.3
—
—
—
0
0
9
50
1.82
0.97
6.8
3.9
5.3
4.8
kpa
—
9
50
9
50
1.82
0.97
6.8
3.9
9.4
9.0
kpa
—
9
50
259
2447
1.25
0.97
15.8
14.6
13.3
13.3
%
0.06
253
2402
9
51
1.78
0.95
6.3
4.2
—
—
—
0
0
6
27
2.24
0.94
4.0
3.6
5.6
6.4
mmol/l
—
6
27
315
3059
1.47
0.93
18.0
16.1
264.4
262.1
e9/l
0.27
305
2962
14
87
1.64
0.89
1.9
1.5
—
—
—
0
0
6
30
2.02
0.87
1.2
1.2
—
—
—
0
0
6
30
2.02
0.87
4.0
3.3
1.2
1.3
mmol/l
—
6
30
55
669
0.79
0.87
2.0
1.7
—
—
—
0
0
315
3064
1.44
0.86
17.9
15.9
87.8
88.1
fl
0.51
309
3022
31
232
1.37
0.85
1.3
1.2
—
—
—
0
0
315
3065
1.44
0.84
18.0
16.0
4.6
4.6
e12/l
0.26
302
2964
315
3065
1.44
0.84
17.9
15.9
29.4
29.5
pg
0.77
310
3024
243
2294
1.21
0.84
4.2
4.0
1.9
1.9
mu/l
0.15
227
2138
148
1338
1.19
0.83
5.8
6.6
6.2
6.1
mmol/l
0.04
140
1219
15
97
1.57
0.82
10.3
16.5
0.7
0.7
%
0.01
15
97
8
47
1.72
0.81
1.0
1.1
—
—
—
0
0
315
3068
1.42
0.80
18.0
16.0
6.9
6.9
e9/l
0.12
302
2966
6
33
1.83
0.79
1.0
1.1
—
—
—
0
0
315
3069
1.42
0.79
18.3
16.2
134.8
135.3
g/l
0.26
310
3025
0
26
0.00
0.78
0.0
1.0
—
—
—
0
0
10
59
1.72
0.76
1.5
1.3
—
—
—
0
0
9
53
1.72
0.76
2.3
1.7
—
—
—
0
0
113
1005
1.19
0.75
6.3
8.2
—
—
—
0
0
46
373
1.27
0.74
11.7
14.9
24.9
24.5
mmol/l
0.48
46
373
7
38
1.86
0.74
2.9
4.0
—
—
—
0
0
44
355
1.28
0.74
11.2
9.9
5.2
5.1
kpa
0.43
44
340
175
1617
1.17
0.73
9.3
10.1
3.9
3.8
e9/l
0.10
155
1374
37
293
1.29
0.71
2.4
2.1
—
—
—
0
0
140
1273
1.17
0.71
3.0
2.8
—
—
—
0
0
39
313
1.28
0.69
2.1
1.7
—
—
—
0
0
5
27
1.86
0.68
2.4
2.3
11.5
12.2
umol/l
—
5
27
15
102
1.49
0.68
3.4
3.7
0.1
0.1
e6/l
0.26
15
96
121
1092
1.17
0.67
9.0
10.4
1.2
1.2
mmol/l
0.94
108
966
7
43
1.64
0.67
3.1
3.3
—
—
—
0
0
56
471
1.23
0.67
2.8
3.6
1.2
1.3
mg/l
0.02
32
336
144
1318
1.16
0.66
3.6
3.1
79.6
64.0
ug/l
0.62
134
1233
5
28
1.80
0.66
1.0
2.0
—
—
—
0
0
37
298
1.27
0.64
11.8
10.4
9.1
9.5
kpa
0.57
37
285
68
588
1.20
0.62
4.5
3.0
1.0
1.0
kg/l
0.38
14
87
23
174
1.35
0.61
6.1
7.5
74.3
62.4
ng/l
0.26
18
163
58
674
0.83
0.61
3.8
3.8
8.9
8.3
mmol/l
0.28
52
599
21
157
1.36
0.60
8.2
14.7
14.7
13.9
kpa
0.21
21
152
21
157
1.36
0.60
8.2
14.7
5.4
5.2
kpa
0.28
21
151
100
896
1.16
0.60
1.6
1.6
—
—
—
0
0
0
20
0.00
0.60
0.0
1.2
—
—
—
0
0
0
21
0.00
0.60
0.0
1.2
—
184.4
—
0
21
0
22
0.00
0.59
0.0
1.3
—
—
—
0
0
12
171
0.69
0.56
2.1
2.2
—
11.5
—
0
9
66
575
1.18
0.56
4.3
3.3
—
—
—
0
0
10
65
1.55
0.56
2.8
4.0
36.2
38.7
umol/l
—
10
59
85
758
1.16
0.55
6.8
8.0
—
—
—
0
0
157
1464
1.14
0.53
7.4
8.3
0.2
0.2
e9/l
0.82
142
1274
59
512
1.18
0.53
2.6
2.5
158.4
100.8
ug/g
0.41
45
392
6
98
0.61
0.53
1.5
1.5
—
—
—
0
0
9
63
1.44
0.52
4.6
3.3
128.0
285.5
ug/l
—
9
55
39
325
1.23
0.52
3.7
4.8
6.2
8.3
umol/l
0.52
32
267
159
1487
1.13
0.51
7.0
7.6
2.3
2.2
e9/l
0.14
142
1303
114
1044
1.14
0.51
4.2
4.4
—
—
—
0
0
152
1418
1.13
0.51
7.2
7.7
0.6
0.6
e9/l
0.58
136
1207
13
178
0.72
0.50
1.5
1.4
—
—
—
0
0
206
1960
1.13
0.49
3.5
3.1
5.5
5.6
mmol/l
0.39
185
1804
21
163
1.31
0.49
1.2
1.2
0.1
1.9
u/ml
1.62
12
91
73
649
1.16
0.49
3.2
2.3
2.7
2.7
mg/l
0.06
66
561
44
375
1.20
0.48
1.3
1.2
—
—
—
0
0
7
47
1.50
0.48
2.3
1.9
—
—
—
0
0
7
47
1.50
0.48
2.3
1.9
—
—
—
0
0
7
47
1.50
0.48
4.4
7.6
—
—
—
0
0
7
47
1.50
0.48
2.3
1.9
—
—
—
0
0
7
47
1.50
0.48
2.3
1.9
—
—
—
0
0
79
876
0.87
0.47
1.6
1.6
1.7
1.8
g/l
0.33
41
476
152
1423
1.12
0.47
7.2
7.6
0.0
0.0
e9/l
1.57
136
1210
63
556
1.16
0.47
3.6
3.8
7.4
7.4
ph
0.32
14
104
53
605
0.85
0.46
5.7
5.1
—
—
—
0
0
19
148
1.30
0.44
1.1
1.2
0.2
1.1
u/ml
0.99
11
92
6
94
0.63
0.42
1.5
1.4
—
—
—
0
0
6
94
0.63
0.42
1.5
1.4
—
—
—
0
0
22
271
0.80
0.42
2.1
2.4
—
—
—
0
0
5
33
1.52
0.41
1.0
1.1
—
—
—
0
0
0
15
0.00
0.41
0.0
1.5
—
—
—
0
0
0
15
0.00
0.41
0.0
1.3
—
—
—
0
0
0
17
0.00
0.40
0.0
1.3
—
—
—
0
0
0
17
0.00
0.40
0.0
1.3
—
—
—
0
0
5
34
1.48
0.40
1.4
2.7
—
782.0
—
0
7
8
61
1.32
0.40
16.1
5.5
—
—
—
0
0
50
440
1.16
0.39
2.7
3.1
—
—
—
0
0
0
19
0.00
0.39
0.0
1.2
—
—
—
0
0
0
19
0.00
0.39
0.0
1.1
—
—
—
0
0
32
375
0.84
0.39
1.6
1.9
—
—
—
0
0
5
37
1.36
0.37
1.0
2.3
—
—
—
0
0
11
81
1.37
0.36
10.6
21.3
—
—
—
0
0
6
43
1.40
0.35
1.0
1.0
—
—
—
0
0
6
43
1.40
0.35
1.5
2.8
1.7
1.6
mmol/l
—
6
43
140
1323
1.10
0.35
7.0
7.8
0.6
0.6
%
0.11
134
1249
46
407
1.15
0.34
1.6
1.4
16.6
20.6
nmol/l
1.36
40
348
33
380
0.85
0.34
1.6
1.9
—
—
—
0
0
6
86
0.69
0.33
1.3
1.3
—
—
—
0
0
6
46
1.31
0.33
1.7
1.4
—
—
—
0
0
33
379
0.86
0.33
1.6
1.9
—
—
—
0
0
24
202
1.20
0.32
1.5
1.4
—
—
—
0
0
143
1358
1.09
0.32
9.1
9.9
0.0
0.0
e9/l
0.50
120
1059
33
377
0.86
0.31
1.6
1.9
—
—
—
0
0
17
138
1.24
0.31
5.2
3.3
—
—
—
0
0
11
84
1.32
0.30
4.5
8.5
—
—
—
0
0
54
489
1.12
0.30
2.7
3.0
582.5
566.7
mosm/kgh2o
0.17
47
422
20
236
0.84
0.27
3.6
3.4
—
—
—
0
0
8
66
1.22
0.27
1.5
2.6
—
—
—
0
0
201
1947
1.08
0.26
3.6
3.4
2.8
2.7
mmol/l
0.85
187
1825
5
71
0.70
0.26
1.0
1.8
—
—
—
0
0
19
160
1.20
0.26
3.5
4.3
0.5
0.3
%
—
6
33
11
137
0.80
0.25
1.1
1.1
—
—
—
0
0
11
87
1.27
0.24
1.1
1.1
0.1
0.6
u/ml
—
5
31
9
77
1.17
0.24
1.0
1.1
—
—
—
0
0
148
1421
1.07
0.24
6.9
7.3
54.0
52.4
%
0.73
142
1349
40
362
1.12
0.23
1.1
1.2
15.3
26.4
iu/ml
0.98
11
96
25
219
1.15
0.23
1.3
1.3
—
—
—
0
0
31
346
0.89
0.22
10.2
8.8
0.8
0.8
mmol/l
0.58
31
326
25
283
0.87
0.22
1.2
1.5
—
—
—
0
0
0
11
0.00
0.21
0.0
1.4
—
—
—
0
0
0
11
0.00
0.21
0.0
1.4
—
—
—
0
0
0
11
0.00
0.21
0.0
18.5
—
0.6
—
0
11
0
11
0.00
0.21
0.0
2.9
—
0.2
—
0
11
0
10
0.00
0.21
0.0
1.0
—
159.3
—
0
10
0
10
0.00
0.21
0.0
1.6
—
—
—
0
0
0
10
0.00
0.21
0.0
1.4
—
—
—
0
0
0
12
0.00
0.21
0.0
1.5
—
0.7
—
0
12
0
12
0.00
0.21
0.0
1.4
—
—
—
0
0
0
14
0.00
0.20
0.0
3.5
—
—
—
0
0
32
353
0.90
0.19
1.6
1.9
—
—
—
0
0
17
146
1.17
0.19
1.2
1.2
1.3
4.5
u/ml
—
7
43
41
376
1.10
0.19
6.1
9.3
0.8
1.1
mmol/l
0.24
31
280
19
166
1.15
0.18
5.1
5.2
0.1
0.1
%
—
7
44
74
701
1.07
0.17
2.9
3.0
—
—
—
0
0
35
381
0.91
0.17
4.5
4.3
7.7
57.1
mg/mmol
0.58
25
256
19
167
1.15
0.17
13.3
17.8
1.1
1.1
mg/l
0.40
19
162
5
68
0.73
0.17
1.0
1.6
—
53.3
—
0
12
5
69
0.72
0.17
1.0
1.1
—
—
—
0
0
8
70
1.15
0.16
1.0
1.0
—
—
—
0
0
8
71
1.13
0.16
2.0
1.9
0.3
0.6
nmol/l
—
8
60
58
613
0.93
0.15
1.9
1.8
—
—
—
0
0
13
150
0.86
0.15
4.7
4.1
—
—
—
0
0
189
1850
1.05
0.14
3.1
3.0
1.2
1.2
mmol/l
0.07
175
1744
32
346
0.92
0.14
1.3
1.4
651.4
546.0
titre
—
7
60
10
84
1.20
0.14
1.1
1.2
—
—
—
0
0
20
180
1.12
0.13
1.8
1.8
—
—
—
0
0
76
728
1.06
0.13
2.1
2.0
—
—
—
0
0
12
138
0.86
0.13
2.3
2.6
0.7
0.6
ug/l
—
7
86
15
168
0.89
0.12
1.9
2.4
—
—
—
0
0
34
363
0.93
0.11
3.7
3.6
43.5
123.6
mg/l
1.49
23
246
71
682
1.05
0.11
3.3
2.4
—
—
—
0
0
28
260
1.08
0.11
1.3
1.2
—
33.1
—
0
8
123
1199
1.04
0.11
4.2
3.3
0.0
0.0
estimate
0.00
22
257
16
177
0.90
0.10
1.3
1.4
218.6
270.4
miu/ml
—
10
91
148
1449
1.04
0.10
7.1
7.5
31.5
32.9
%
0.72
143
1377
199
1959
1.04
0.10
3.4
3.2
4.5
4.4
mmol/l
0.30
185
1856
18
164
1.10
0.10
5.2
5.2
0.0
0.0
%
—
7
40
5
45
1.11
0.10
2.6
13.9
1.3
1.2
mmol/l
—
5
38
196
1932
1.03
0.09
3.4
3.1
1.4
1.4
mmol/l
0.58
184
1815
123
1203
1.03
0.09
5.9
4.6
0.0
0.0
estimate
0.00
24
266
6
54
1.11
0.09
1.7
1.2
—
—
—
0
0
30
283
1.07
0.08
1.8
1.5
—
—
—
0
0
179
1764
1.03
0.08
3.9
3.8
8.2
8.7
mm/h
0.32
163
1633
7
67
1.05
0.08
1.9
2.4
140.9
131.5
g/l
—
7
48
19
176
1.08
0.07
5.3
5.1
1.3
0.7
%
—
7
49
8
74
1.08
0.07
1.5
3.2
3.7
3.4
mmol/l
—
8
69
65
670
0.96
0.07
3.5
2.9
—
—
—
0
0
12
108
1.11
0.07
1.2
1.5
—
—
—
0
0
14
153
0.91
0.07
1.0
1.0
—
—
—
0
0
7
80
0.87
0.07
2.0
1.2
—
—
—
0
0
9
84
1.07
0.07
1.4
1.1
—
—
—
0
0
9
87
1.04
0.07
1.6
1.7
—
—
—
0
0
29
275
1.06
0.07
1.2
1.2
—
—
—
0
0
164
1661
0.97
0.06
4.8
4.1
—
—
—
0
0
9
105
0.85
0.06
1.0
1.2
—
—
—
0
0
33
345
0.95
0.06
1.3
1.2
15.4
4.9
u/ml
0.32
12
128
68
662
1.03
0.06
4.1
3.0
2.4
2.4
mmol/l
0.04
61
596
28
294
0.95
0.06
1.6
2.0
—
—
—
0
0
14
129
1.09
0.05
1.4
1.4
—
—
—
0
0
123
1211
1.02
0.05
4.2
3.3
0.0
0.0
estimate
0.00
20
258
50
485
1.04
0.05
1.3
1.6
—
—
—
0
0
13
120
1.09
0.05
1.0
1.0
7.0
8.3
mu/l
0.48
13
113
70
712
0.98
0.03
1.6
1.7
—
—
—
0
0
96
969
0.99
0.02
1.6
1.6
1.3
2.7
u/ml
0.76
20
199
167
1679
0.99
0.01
4.4
4.0
36.9
37.2
mmol/mol
0.17
154
1581
16
167
0.96
0.01
1.3
1.2
—
—
—
0
0
24
234
1.03
0.00
1.4
1.3
54.8
141.1
iu/ml
—
5
80
10
95
1.05
0.00
1.0
1.0
—
—
—
0
0
34
345
0.98
0.00
3.2
3.8
437.3
511.7
ng/l
0.08
13
199
65
653
0.99
0.00
4.7
3.4
0.0
0.0
estimate
0.00
23
252
13
131
0.99
0.00
1.6
1.7
—
—
—
0
0
26
258
1.01
0.00
5.2
4.3
1.8
1.7
ug/l
0.02
20
227
34
335
1.02
0.00
9.9
11.4
—
—
—
0
0
96
956
1.01
0.00
2.2
2.2
—
—
—
0
0
0
5
0.00
0.00
0.0
5.0
—
12.0
—
0
5
0
5
0.00
0.00
0.0
1.2
—
86.8
—
0
5
0
5
0.00
0.00
0.0
7.2
—
137.2
—
0
5
0
5
0.00
0.00
0.0
3.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
4.8
—
—
—
0
0
0
9
0.00
0.00
0.0
1.2
—
—
—
0
0
6
67
0.89
0.00
1.0
1.2
—
—
—
0
0
0
9
0.00
0.00
0.0
1.7
—
—
—
0
0
0
8
0.00
0.00
0.0
1.5
—
79.5
—
0
8
0
6
0.00
0.00
0.0
2.5
—
—
—
0
0
9
95
0.95
0.00
2.1
2.1
—
—
—
0
0
0
9
0.00
0.00
0.0
1.8
—
152.7
—
0
9
0
7
0.00
0.00
0.0
1.7
—
—
—
0
0
0
8
0.00
0.00
0.0
1.8
—
—
—
0
0
9
97
0.93
0.00
1.3
1.3
0.2
0.2
g/l
—
9
92
8
80
1.00
0.00
1.0
1.2
—
1.6
—
0
6
0
6
0.00
0.00
0.0
13.5
—
—
—
0
0
0
8
0.00
0.00
0.0
1.7
—
8.2
—
0
8
0
9
0.00
0.00
0.0
4.4
—
—
—
0
0
0
6
0.00
0.00
0.0
2.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
0
9
0.00
0.00
0.0
1.7
—
—
—
0
0
0
9
0.00
0.00
0.0
1.3
—
—
—
0
0
8
81
0.99
0.00
1.3
1.2
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
0.00
0.0
1.2
—
—
—
0
0
8
81
0.99
0.00
1.3
1.2
—
—
—
0
0
0
6
0.00
0.00
0.0
5.2
—
0.5
—
0
6
7
71
0.99
0.00
10.0
10.7
25.1
23.6
mmol/l
—
7
63
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
6
65
0.92
0.00
1.3
3.9
—
—
—
0
0

Mortality – FinRegistry

Association

Association between endpoint Q17_CONGEN_MALFO_EYELID_LACRIMAL_APPARA_ORBIT and mortality.

Females

Parameter HR [95% CI] p-value
Q17_CONGEN_MALFO_EYELID_LACRIMAL_APPARA_ORBIT 1.242 [0.85, 1.81] 0.263
Birth year 1.0 [0.99, 1.01] 0.939

During the follow-up period (1.1.1998 — 31.12.2019), 61 out of 5131 females with Q17_CONGEN_MALFO_EYELID_LACRIMAL_APPARA_ORBIT died.

Males

Parameter HR [95% CI] p-value
Q17_CONGEN_MALFO_EYELID_LACRIMAL_APPARA_ORBIT 1.42 [1.06, 1.9] 0.018
Birth year 0.986 [0.98, 1.0] 0.004

During the follow-up period (1.1.1998 — 31.12.2019), 66 out of 5456 males with Q17_CONGEN_MALFO_EYELID_LACRIMAL_APPARA_ORBIT died.

Mortality risk

Mortality risk for people of age

years, who have Q17_CONGEN_MALFO_EYELID_LACRIMAL_APPARA_ORBIT.

N-year risk Females Males
1 0.099% 0.215%
5 0.743% 1.521%
10 2.266% 4.077%
15 4.051% 7.793%
20 7.108% 12.713%

Relationships between endpoints

Index endpoint: Q17_CONGEN_MALFO_EYELID_LACRIMAL_APPARA_ORBIT – Congenital malformations of eyelid, lacrimal apparatus and orbit

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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