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Abnormality of red blood cells

R18_ABNORMALITY_RED_BLOOD_CELLS

Endpoint definition

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

519972

1. Apply sex-specific rule

None

519972

2. Check conditions

None

519972

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 R71
  • Cause of death: ICD-10 R71

2 out of 7 registries used, show all original rules.

188

4. Check minimum number of events

None

188

5. Include endpoints

None

188

6. Filter based on genotype QC (FinnGen only)

182

Control definitions (FinnGen only)

Control exclude
R18_ABNORMAL_FINDI_EXAMI_BLOOD_WO_DIAGNOSIS

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF4
Parent code in ICD-10
R7
Name in latin
Abnormitas erythrocytorum

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

-FinnGen-

Key figures

All Female Male
Number of individuals 182 91 91
Unadjusted period prevalence (%) 0.04 0.03 0.04
Median age at first event (years) 57.57 53.57 61.57

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
188
Matched controls
1880
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
R71
ICD-10 Finland
Abnormality of red blood cells
+∞
269.8
188
*
D75.1
ICD-10 Finland
Secondary polycythaemia
+∞
27.8
26
*
XW000
NOMESCO Finland
Bone marrow biopsy
11.0
26.0
30
32
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
5.0
13.2
31
71
D45
ICD-10 Finland
Polycythaemia vera
17.3
8.7
13
8
207
Kela drug reimbursment
Chronic arrhythmias
3.1
8.2
39
146
Z01.8
ICD-10 Finland
Other specified special examinations
2.7
7.5
51
231
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
3.0
6.9
33
123
M10.9
ICD-10 Finland
Gout, unspecified
3.9
6.8
21
59
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.2
6.5
94
588
ZXE00
NOMESCO Finland
One hour or less
2.2
6.5
85
511
D75.9
ICD-10 Finland
Disease of blood and blood-forming organs, unspecified
18.8
6.3
9
5
290
Kela drug reimbursment
Apixaban, dabigatran, edoxaban and rivaroxaban for the treatment of atrial fibrillation
2.7
6.1
36
151
M04AA01
ATC
allopurinol; systemic
2.7
6.1
35
145

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
67
179
5.26
24.74
1.9
2.0
29.17
22.50
%
2.28
58
154
68
188
5.10
24.03
2.0
2.0
2.33
2.34
g/l
0.02
60
171
71
209
4.85
23.13
2.0
2.0
15.84
13.33
umol/l
1.78
65
193
62
168
5.01
22.27
2.6
2.8
1.89
1.69
%
0.45
55
156
49
120
5.17
19.66
2.9
2.9
81.92
67.26
e9/l
1.99
34
98
133
685
4.22
19.02
7.4
6.6
—
—
—
0
0
126
680
3.59
15.59
6.3
5.9
0.78
0.64
%
1.84
118
635
133
744
3.69
15.50
5.8
5.9
0.64
0.58
e9/l
2.15
116
648
133
747
3.67
15.34
5.8
5.9
0.05
0.04
e9/l
1.59
118
652
134
762
3.64
15.03
5.9
5.9
2.16
1.95
e9/l
0.44
121
681
134
766
3.61
14.81
6.4
6.2
0.21
0.18
e9/l
1.10
121
674
126
699
3.43
14.51
6.2
5.9
2.86
2.72
%
0.24
119
656
126
703
3.40
14.30
6.4
6.2
9.02
8.63
%
0.86
118
665
113
596
3.25
14.01
3.3
2.4
171.12
120.24
ug/l
1.67
103
544
127
719
3.36
13.92
6.4
6.0
28.42
27.60
%
0.32
118
678
126
711
3.34
13.87
5.9
5.8
55.65
57.31
%
0.72
118
670
30
66
5.22
13.37
1.6
2.4
1.48
1.49
g/l
0.01
25
57
32
86
4.28
11.13
1.9
2.2
—
—
—
0
0
137
874
3.09
11.05
9.2
9.6
4.34
4.13
e9/l
0.43
124
763
20
38
5.77
10.36
1.6
4.3
244.35
39.02
mg/l
0.44
15
32
20
38
5.77
10.36
1.7
4.3
20.06
23.51
mg/l
0.38
15
32
70
325
2.84
10.20
2.6
2.0
3.02
3.12
mg/l
0.10
57
284
34
105
3.73
9.73
1.9
2.5
65.66
66.04
g/l
0.11
29
96
60
266
2.84
9.44
2.3
1.7
1183.52
1249.04
nmol/l
0.18
46
199
95
566
2.37
7.78
2.3
1.9
91.91
93.19
pmol/l
0.08
55
285
117
766
2.40
7.67
6.4
6.2
14.52
11.44
umol/l
1.56
112
727
111
719
2.33
7.34
5.7
6.7
1.21
1.21
mmol/l
0.20
83
623
64
327
2.45
7.32
1.9
1.6
21.76
21.36
nmol/l
0.06
54
275
105
672
2.27
7.05
6.4
5.7
1.21
1.21
mmol/l
0.29
93
610
16
27
6.37
6.46
1.1
1.6
—
—
—
0
0
152
1163
2.60
6.42
8.6
7.1
82.70
77.25
u/l
0.95
143
1080
16
28
6.14
6.30
1.6
5.2
—
—
—
0
0
103
675
2.16
6.28
17.1
12.0
1.20
1.25
inr
0.30
40
208
96
620
2.12
5.99
5.3
4.1
35.02
35.45
g/l
0.31
89
579
16
32
5.36
5.71
3.4
2.9
2.36
2.62
mmol/l
0.16
11
20
16
32
5.36
5.71
3.4
2.9
8.11
8.68
kpa
0.55
16
32
16
32
5.36
5.71
3.4
2.9
4.91
4.95
kpa
0.08
16
32
15
28
5.72
5.67
1.8
2.8
19.98
16.64
%
—
6
14
30
120
2.78
5.54
5.9
4.1
1.20
1.22
mmol/l
0.70
23
102
57
310
2.20
5.44
1.9
1.8
428.97
465.98
pmol/l
0.31
38
261
11
14
8.27
5.42
1.0
1.1
—
—
—
0
0
12
18
7.04
5.34
3.0
1.9
35.33
33.61
pg
0.83
12
18
146
1136
2.28
5.30
4.4
4.0
13.16
12.10
mm/h
0.29
134
1035
99
672
2.00
5.16
12.7
9.5
0.01
0.00
e9/l
0.60
81
545
24
90
2.91
4.97
5.2
8.2
24.70
25.21
mmol/l
0.35
24
90
75
467
2.01
4.94
5.1
3.7
7.41
7.40
ph
0.29
19
81
29
122
2.63
4.85
4.8
5.2
0.50
0.66
%
0.21
12
49
28
116
2.66
4.83
4.9
5.3
0.00
0.12
%
1.24
11
43
72
446
2.00
4.79
3.3
3.0
7.43
7.66
mmol/l
0.13
51
378
14
32
4.64
4.54
1.2
1.3
—
—
—
0
0
72
454
1.95
4.50
4.2
3.0
17.22
188.44
e6/l
0.64
56
346
52
292
2.08
4.49
2.6
3.0
543.81
543.34
mosm/kgh2o
0.01
43
248
117
869
1.92
4.41
4.3
4.5
6.87
6.65
mmol/l
0.51
110
822
63
387
1.94
4.20
4.8
4.0
—
—
—
0
0
26
112
2.53
4.14
4.5
5.1
0.09
0.55
%
1.33
11
42
55
328
1.96
3.97
1.7
1.9
1.92
1.22
mg/l
0.39
46
255
64
405
1.88
3.86
3.0
2.7
373.07
7724.87
umol/l
1.96
55
351
64
406
1.87
3.82
3.2
3.1
57.39
358.24
mg/l
0.75
39
261
52
309
1.94
3.78
2.3
2.4
4.14
4.85
e6/l
0.28
44
274
42
232
2.04
3.74
4.4
2.9
4.90
3.30
e6/l
0.25
26
129
63
403
1.85
3.64
4.5
2.8
—
—
—
0
0
67
437
1.83
3.64
3.8
3.7
9.84
7.84
mg/mmol
0.14
38
272
77
524
1.80
3.64
5.1
3.5
60.24
82.72
e6/l
0.21
59
371
27
126
2.33
3.63
3.4
3.8
—
—
—
0
0
64
412
1.84
3.62
4.4
2.9
0.31
0.39
e6/l
0.30
50
303
38
206
2.06
3.55
1.3
1.2
—
—
—
0
0
25
115
2.35
3.47
5.4
5.2
0.00
0.21
%
—
8
42
12
32
3.93
3.46
2.1
2.3
—
—
—
0
0
11
27
4.26
3.45
4.0
3.6
62.00
63.33
%
0.15
11
27
11
27
4.26
3.45
4.0
3.0
4.74
5.45
e9/l
0.42
11
27
170
1491
2.46
3.43
17.7
13.5
26.06
23.68
mg/l
0.40
141
1175
64
420
1.79
3.37
3.4
3.8
—
—
—
0
0
12
33
3.81
3.36
1.4
1.2
—
—
—
0
0
123
977
1.75
3.25
3.9
4.1
—
—
—
0
0
51
316
1.84
3.22
1.7
1.3
2.68
2.38
g/l
0.68
38
172
8
16
5.17
3.08
1.0
1.3
—
—
—
0
0
135
1110
1.77
3.06
4.3
3.9
14.72
14.82
pmol/l
0.17
122
995
67
466
1.68
2.80
2.8
2.3
54.18
63.91
u/l
0.46
60
433
24
121
2.13
2.70
8.0
8.5
—
—
—
0
0
76
555
1.62
2.59
3.7
3.8
23.86
33.20
ng/l
0.91
56
398
57
387
1.68
2.58
1.3
1.4
—
—
—
0
0
5
7
7.30
2.56
1.0
2.0
29.86
31.00
umol/l
—
5
7
160
1413
1.89
2.51
4.6
3.9
1.52
1.28
mmol/l
2.64
150
1281
52
347
1.69
2.50
1.3
1.2
0.61
1.74
u/ml
0.90
14
81
31
177
1.90
2.49
1.4
1.4
506.67
411.43
titre
—
6
42
155
1358
1.81
2.47
5.2
4.6
1.92
1.89
mu/l
0.15
144
1230
60
418
1.64
2.44
2.9
3.4
—
—
—
0
0
157
1386
1.81
2.36
6.6
5.6
39.42
40.06
mmol/mol
0.33
144
1280
125
1044
1.59
2.31
4.4
3.7
—
—
—
0
0
163
1461
1.87
2.25
5.1
4.4
1.32
1.48
mmol/l
5.02
152
1329
7
19
3.78
2.17
3.1
1.9
—
—
—
0
0
163
1467
1.84
2.13
5.3
4.4
4.48
4.66
mmol/l
1.42
153
1347
6
15
4.09
2.05
1.0
1.1
—
—
—
0
0
59
426
1.56
2.03
3.1
3.2
—
—
—
0
0
90
713
1.50
2.02
3.3
3.5
0.00
0.01
estimate
0.50
28
155
18
92
2.06
1.98
2.3
3.5
7.43
7.41
ph
—
5
11
160
1442
1.74
1.95
5.4
4.4
6.14
5.96
mmol/l
1.03
139
1304
172
1584
2.01
1.95
23.0
15.7
84.72
76.87
umol/l
1.23
172
1584
6
16
3.84
1.95
2.7
1.7
11.15
2.22
u/ml
—
6
16
173
1599
2.03
1.90
13.3
10.2
28.53
26.46
u/l
0.83
165
1539
8
28
2.94
1.88
1.1
2.4
—
—
—
0
0
89
712
1.47
1.86
4.5
4.8
0.00
0.00
estimate
-0.00
26
144
60
443
1.52
1.85
2.5
2.3
—
—
—
0
0
11
48
2.37
1.74
1.7
1.6
23.35
25.31
iu/l
0.07
11
38
5
13
3.92
1.72
1.2
1.1
—
—
—
0
0
14
69
2.11
1.69
1.2
1.1
—
—
—
0
0
10
40
2.58
1.69
1.3
1.2
—
—
—
0
0
20
113
1.86
1.68
1.3
1.5
—
—
—
0
0
27
168
1.71
1.66
1.4
1.3
—
—
—
0
0
73
572
1.45
1.66
1.8
2.1
—
—
—
0
0
63
480
1.47
1.65
3.0
3.2
2.36
2.35
mmol/l
0.33
57
422
89
725
1.43
1.63
3.3
3.5
0.00
0.00
estimate
-0.00
28
138
163
1496
1.67
1.60
5.7
4.9
2.65
2.76
mmol/l
0.81
153
1364
27
170
1.69
1.60
1.4
1.3
—
—
—
0
0
26
163
1.69
1.56
1.3
1.6
—
—
—
0
0
26
164
1.68
1.53
2.0
1.5
—
—
—
0
0
5
15
3.39
1.53
1.8
1.6
—
—
—
0
0
5
15
3.39
1.53
2.2
1.1
—
—
—
0
0
5
15
3.39
1.53
1.4
2.2
—
—
—
0
0
7
29
2.47
1.40
3.1
2.0
—
—
—
0
0
176
1662
1.92
1.39
29.6
19.8
42.62
40.45
%
3.09
169
1562
176
1663
1.91
1.37
30.2
19.7
4.70
4.51
e12/l
1.96
171
1610
33
229
1.53
1.34
1.4
1.2
0.68
9.42
u/ml
—
8
93
34
240
1.51
1.28
1.4
1.2
49.86
36.60
iu/ml
—
10
83
5
19
2.67
1.22
1.8
1.6
28.46
32.98
g/l
—
5
19
51
394
1.40
1.21
3.4
3.7
0.00
0.00
estimate
-0.00
26
139
28
192
1.54
1.20
1.6
1.6
—
—
—
0
0
19
119
1.66
1.17
1.3
1.3
—
—
—
0
0
27
185
1.54
1.17
7.1
7.3
103.81
104.14
mmol/l
0.13
27
185
17
104
1.70
1.14
1.3
1.6
—
—
—
0
0
7
30
2.38
1.13
1.3
1.7
—
—
—
0
0
20
129
1.62
1.11
6.7
3.5
1.75
2.24
mmol/l
0.14
13
104
166
1564
1.52
1.05
17.2
12.5
—
—
—
0
0
16
100
1.66
1.00
3.7
4.3
—
—
—
0
0
66
547
1.32
0.99
3.5
2.9
—
—
—
0
0
37
280
1.40
0.99
3.1
3.6
11.84
175.75
ng/l
1.78
25
219
50
403
1.33
0.91
1.7
1.7
1.50
1.37
mmol/l
0.48
36
335
28
206
1.42
0.88
2.5
1.8
—
—
—
0
0
8
45
1.81
0.85
1.8
1.6
—
—
—
0
0
18
122
1.53
0.84
2.3
4.5
—
—
—
0
0
8
46
1.77
0.83
4.8
3.2
—
—
—
0
0
0
24
0.00
0.80
0.0
1.1
—
—
—
0
0
47
384
1.30
0.77
8.6
7.1
—
—
—
0
0
9
55
1.67
0.74
2.9
1.6
—
—
—
0
0
9
55
1.67
0.74
2.9
1.7
—
—
—
0
0
7
38
1.87
0.74
3.3
2.2
—
—
—
0
0
9
56
1.64
0.73
2.9
1.6
—
—
—
0
0
9
56
1.64
0.73
2.9
1.6
—
—
—
0
0
5
25
2.03
0.73
2.8
2.6
—
—
—
0
0
5
25
2.03
0.73
2.0
2.3
—
—
—
0
0
9
57
1.61
0.72
8.4
4.3
—
—
—
0
0
8
52
1.56
0.60
3.1
1.7
—
—
—
0
0
10
64
1.59
0.60
3.2
3.6
—
—
—
0
0
21
159
1.36
0.58
2.5
4.2
3.23
37.97
ug/l
0.71
16
131
6
36
1.69
0.57
1.2
1.0
—
—
—
0
0
37
306
1.26
0.56
3.1
3.5
1.02
1.02
kg/l
—
5
46
6
40
1.52
0.52
1.2
1.2
—
—
—
0
0
18
137
1.35
0.49
2.1
1.6
—
—
—
0
0
12
85
1.44
0.48
3.0
3.4
4.21
4.50
pmol/l
0.41
12
75
7
49
1.44
0.46
3.0
4.0
—
—
—
0
0
16
122
1.34
0.44
1.3
1.1
—
—
—
0
0
5
33
1.53
0.41
1.2
1.9
—
—
—
0
0
21
169
1.27
0.41
5.7
8.0
2.01
1.15
mmol/l
0.30
15
143
8
60
1.35
0.41
1.5
1.8
—
—
—
0
0
5
36
1.40
0.38
1.2
1.9
119.80
220.10
e6/l
—
5
30
5
36
1.40
0.38
1.2
1.8
1.00
2.54
e6/l
—
5
28
5
36
1.40
0.38
2.4
6.2
—
—
—
0
0
6
41
1.48
0.36
1.0
1.1
—
—
—
0
0
6
42
1.44
0.36
1.0
1.3
—
—
—
0
0
8
107
0.74
0.30
1.1
2.4
—
—
—
0
0
5
71
0.70
0.26
2.0
4.2
—
—
—
0
0
10
78
1.30
0.24
3.5
2.4
—
—
—
0
0
11
135
0.80
0.22
1.5
1.4
—
—
—
0
0
0
11
0.00
0.21
0.0
1.0
—
—
—
0
0
0
10
0.00
0.21
0.0
8.0
—
—
—
0
0
0
10
0.00
0.21
0.0
5.4
—
—
—
0
0
0
10
0.00
0.21
0.0
1.4
—
7.34
—
0
10
0
10
0.00
0.21
0.0
1.2
—
1.73
—
0
10
21
183
1.17
0.21
1.2
1.3
—
—
—
0
0
0
12
0.00
0.21
0.0
3.5
—
46.40
—
0
5
0
12
0.00
0.21
0.0
1.3
—
—
—
0
0
0
13
0.00
0.21
0.0
1.5
—
—
—
0
0
0
13
0.00
0.21
0.0
2.6
—
—
—
0
0
0
14
0.00
0.20
0.0
1.0
—
—
—
0
0
53
502
1.08
0.14
5.0
4.1
1.39
2.16
ug/l
1.54
46
444
9
109
0.82
0.13
2.8
3.3
—
—
—
0
0
34
317
1.09
0.13
3.2
3.2
—
—
—
0
0
32
299
1.08
0.11
2.8
2.8
0.66
0.81
ug/l
0.49
23
181
10
114
0.87
0.10
2.6
1.8
—
—
—
0
0
16
145
1.11
0.09
2.3
1.5
—
—
—
0
0
6
57
1.05
0.08
1.2
1.8
—
—
—
0
0
5
65
0.76
0.08
1.2
1.3
—
—
—
0
0
15
142
1.06
0.02
1.3
1.4
—
—
—
0
0
26
262
0.99
0.00
2.3
1.9
—
—
—
0
0
5
51
0.98
0.00
1.8
1.6
—
—
—
0
0
6
59
1.02
0.00
15.3
8.4
—
—
—
0
0
0
8
0.00
0.00
0.0
1.4
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
7
0.00
-0.00
0.0
4.0
—
43.43
—
0
7
0
7
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.9
—
8.27
—
0
7
0
7
0.00
-0.00
0.0
1.3
—
283.44
—
0
7
0
9
0.00
-0.00
0.0
7.7
—
—
—
0
0
9
93
0.97
-0.00
1.2
1.2
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.3
—
27.63
—
0
9
9
90
1.00
-0.00
1.2
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.8
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.8
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.2
—
0.36
—
0
5
0
5
0.00
-0.00
0.0
1.0
—
907.80
—
0
5

Mortality – FinRegistry

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

Relationships between endpoints

Index endpoint: R18_ABNORMALITY_RED_BLOOD_CELLS – Abnormality of red blood cells

GWS hits: -

This endpoint is excluded from FinRegistry analyses (omitted endpoint).