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Abnormality of red blood cells

R18_ABNORMALITY_RED_BLOOD_CELLS

Endpoint definition

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 R71
  • Cause of death: ICD-10 R71

2 out of 7 registries used, show all original rules.

180

4. Check minimum number of events

None

180

5. Include endpoints

None

180

6. Filter based on genotype QC (FinnGen only)

180

Control definitions (FinnGen only)

Control exclude
R18_ABNORMAL_FINDI_EXAMI_BLOOD_WO_DIAGNOSIS

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF4
Parent code in ICD-10
R7
Name in latin
Abnormitas erythrocytorum

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

-FinnGen-

Key figures

All Female Male
Number of individuals 180 90 90
Unadjusted period prevalence (%) 0.04 0.03 0.04
Median age at first event (years) 58.01 54.67 61.34

-FinnGen-

Age distribution of first events

020405060708090051015202530354045AgeIndividuals

-FinnGen-

Year distribution of first events

1970197519801985199019952000200520102015202020230510152025303540YearIndividuals

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
164
Matched controls
1639
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
R71
ICD-10 Finland
Abnormality of red blood cells
+∞
237.2
164
*
D75.1
ICD-10 Finland
Secondary polycythaemia
59.7
18.4
21
*
XW000
NOMESCO Finland
Bone marrow biopsy
11.3
14.4
27
28
D75.9
ICD-10 Finland
Disease of blood and blood-forming organs, unspecified
83.7
7.5
8
*
D45
ICD-10 Finland
Polycythaemia vera
31.5
7.2
9
*
207
Kela drug reimbursment
Chronic arrhythmias
3.3
6.7
36
130

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
65
176
5.22
23.63
2.0
2.1
29.07
22.35
%
2.23
56
153
65
185
4.93
22.08
2.0
2.0
2.33
2.32
g/l
0.05
58
168
68
206
4.70
21.28
2.0
2.0
15.97
13.18
umol/l
2.01
62
188
57
164
4.62
18.80
2.4
2.7
1.75
1.69
%
0.15
50
154
45
119
4.71
16.32
3.1
2.9
81.34
67.14
e9/l
1.84
33
98
98
460
3.48
15.36
6.2
5.9
—
—
—
0
0
127
709
3.69
14.88
5.8
6.0
0.64
0.58
e9/l
1.75
111
613
120
647
3.56
14.86
6.3
6.1
0.78
0.64
%
1.74
112
603
127
712
3.66
14.71
5.8
6.1
0.05
0.04
e9/l
1.33
112
619
128
729
3.62
14.29
6.3
6.4
0.21
0.18
e9/l
0.90
115
641
127
725
3.55
14.02
5.9
6.1
2.16
1.96
e9/l
0.37
114
644
120
665
3.41
13.84
6.2
6.1
2.90
2.74
%
0.28
113
620
120
669
3.38
13.62
6.3
6.3
9.05
8.66
%
0.83
112
631
107
569
3.17
12.95
3.4
2.4
178.14
124.41
ug/l
1.68
97
520
120
684
3.26
12.82
6.4
6.2
28.57
27.46
%
0.45
111
640
119
677
3.24
12.72
5.9
5.9
55.32
57.37
%
0.91
111
634
72
315
3.14
12.09
4.7
5.4
—
—
—
0
0
28
64
5.00
11.93
1.6
2.4
1.53
1.49
g/l
0.06
23
56
131
833
3.10
10.69
9.3
10.0
4.29
4.12
e9/l
0.34
118
726
68
314
2.87
10.07
2.6
2.0
3.03
3.15
mg/l
0.11
55
275
58
255
2.88
9.31
2.3
1.7
1197.84
1258.49
nmol/l
0.16
44
194
30
89
3.84
9.10
2.0
2.1
—
—
—
0
0
15
27
5.97
8.17
1.6
5.3
—
—
—
0
0
16
31
5.57
8.09
3.4
3.0
2.36
2.61
mmol/l
0.15
11
19
16
31
5.57
8.09
3.4
3.0
8.11
8.61
kpa
0.46
16
31
16
31
5.57
8.09
3.4
3.0
4.91
4.96
kpa
0.10
16
31
93
549
2.44
7.92
2.3
1.9
92.17
92.69
pmol/l
0.03
53
274
15
28
5.75
7.87
1.8
2.8
19.98
16.64
%
—
6
14
12
18
7.07
7.70
3.0
1.8
35.33
34.06
pg
0.55
12
18
14
26
5.75
7.37
1.1
1.6
—
—
—
0
0
107
693
2.34
7.13
5.9
6.9
1.21
1.21
mmol/l
0.26
79
594
112
740
2.36
7.12
6.5
6.3
14.20
11.46
umol/l
1.26
107
705
90
548
2.28
6.86
12.4
7.3
1.21
1.23
inr
0.10
36
171
10
14
7.50
6.77
1.0
1.1
—
—
—
0
0
61
320
2.37
6.54
2.0
1.6
22.39
21.34
nmol/l
0.17
52
267
100
649
2.22
6.38
6.6
5.9
1.21
1.21
mmol/l
0.35
88
588
146
1121
2.60
6.10
8.7
7.2
82.07
77.46
u/l
0.73
137
1041
93
600
2.14
5.88
5.3
4.1
34.95
35.39
g/l
0.31
86
561
14
33
4.52
5.67
1.2
1.2
—
—
—
0
0
30
119
2.83
5.64
5.9
4.1
1.20
1.22
mmol/l
0.69
23
103
96
638
2.08
5.49
12.9
9.7
0.01
0.00
e9/l
0.60
79
516
55
298
2.22
5.33
1.9
1.8
432.72
472.17
pmol/l
0.32
36
253
139
1083
2.24
4.98
4.5
4.1
13.38
12.23
mm/h
0.30
128
986
28
115
2.70
4.92
4.9
5.3
0.00
0.13
%
—
10
40
29
122
2.64
4.87
4.8
5.2
0.55
0.51
%
0.04
11
42
70
432
2.02
4.74
3.2
3.0
6.95
7.61
mmol/l
0.60
49
363
11
25
4.62
4.63
4.0
3.4
62.00
63.76
%
0.20
11
25
11
25
4.62
4.63
4.0
2.8
4.74
5.56
e9/l
0.48
11
25
51
282
2.13
4.63
2.6
2.8
539.26
559.10
mosm/kgh2o
0.30
42
240
72
453
1.98
4.59
5.3
3.8
7.41
7.40
ph
0.28
19
82
23
89
2.82
4.51
5.4
8.2
24.52
25.23
mmol/l
0.56
23
89
12
31
4.08
4.33
2.1
2.4
—
—
—
0
0
70
446
1.93
4.24
4.2
3.0
17.59
186.71
e6/l
0.61
54
338
26
112
2.54
4.16
4.5
5.1
0.14
0.38
%
—
7
32
112
838
1.89
4.08
4.4
4.6
6.89
6.70
mmol/l
0.41
105
790
27
121
2.45
3.98
3.4
3.8
—
—
—
0
0
42
228
2.10
3.95
4.4
2.9
4.90
3.10
e6/l
0.29
26
122
61
382
1.90
3.83
3.1
2.7
378.88
8243.52
umol/l
1.96
52
328
63
402
1.87
3.72
3.2
3.1
58.88
362.08
mg/l
0.75
38
259
66
429
1.85
3.67
4.4
3.9
10.10
8.14
mg/mmol
0.14
37
269
63
407
1.84
3.55
4.4
2.9
0.32
0.40
e6/l
0.29
49
297
75
512
1.80
3.53
5.1
3.6
62.10
83.15
e6/l
0.19
57
362
25
115
2.36
3.48
5.4
5.2
0.00
0.22
%
—
8
37
62
401
1.83
3.47
4.5
2.8
—
—
—
0
0
50
306
1.88
3.31
2.4
2.4
4.38
4.97
e6/l
0.20
40
268
11
33
3.49
3.25
1.5
1.2
—
—
—
0
0
36
198
2.02
3.24
1.3
1.2
—
—
—
0
0
58
376
1.80
3.19
5.2
4.1
—
—
—
0
0
162
1425
2.37
3.13
18.0
13.8
24.43
23.71
mg/l
0.11
133
1122
61
405
1.77
3.08
3.5
3.9
—
—
—
0
0
50
314
1.82
3.03
1.7
1.9
1.91
1.26
mg/l
0.32
42
245
129
1059
1.77
2.97
4.3
3.9
14.79
14.84
pmol/l
0.08
116
950
117
935
1.72
2.97
4.0
4.2
—
—
—
0
0
48
300
1.82
2.95
1.7
1.3
2.67
2.37
g/l
0.66
36
164
30
165
1.98
2.70
1.4
1.4
506.67
371.00
titre
—
6
40
64
446
1.67
2.66
2.8
2.3
54.02
54.01
u/l
0.00
57
417
74
539
1.63
2.58
3.8
3.9
23.86
31.66
ng/l
0.72
56
388
7
16
4.51
2.50
1.0
1.3
—
—
—
0
0
148
1294
1.81
2.41
5.2
4.7
1.95
1.89
mu/l
0.26
137
1170
23
120
2.05
2.39
8.3
8.8
—
—
—
0
0
150
1328
1.78
2.19
6.8
5.7
39.37
40.13
mmol/mol
0.40
138
1230
10
37
2.80
2.14
1.3
1.2
—
—
—
0
0
152
1355
1.78
2.10
4.6
4.0
1.52
1.28
mmol/l
2.38
142
1228
56
398
1.59
2.09
3.0
3.5
—
—
—
0
0
18
90
2.11
2.09
2.3
3.6
7.43
7.41
ph
—
5
11
6
15
4.10
2.05
2.7
1.5
11.15
2.24
u/ml
—
6
15
11
45
2.54
1.97
1.7
1.5
23.35
25.94
iu/l
0.10
11
36
5
11
4.64
1.95
1.4
1.3
—
—
—
0
0
52
369
1.58
1.94
1.3
1.4
—
—
—
0
0
56
405
1.56
1.92
3.2
3.3
—
—
—
0
0
118
1000
1.52
1.91
4.6
3.7
—
—
—
0
0
8
28
2.94
1.88
1.1
2.4
—
—
—
0
0
47
328
1.59
1.88
1.3
1.2
0.52
1.74
u/ml
0.99
12
79
155
1403
1.75
1.85
5.1
4.4
1.33
1.48
mmol/l
4.65
144
1275
71
549
1.48
1.77
1.8
2.1
—
—
—
0
0
164
1514
1.94
1.76
23.5
16.1
85.76
77.29
umol/l
1.30
164
1514
155
1409
1.72
1.74
5.3
4.4
4.47
4.66
mmol/l
1.33
145
1291
5
13
3.92
1.72
1.2
1.1
—
—
—
0
0
5
13
3.92
1.72
1.4
2.2
—
—
—
0
0
165
1530
1.94
1.69
13.4
10.4
28.41
26.32
u/l
0.80
157
1472
152
1378
1.66
1.69
5.5
4.5
6.17
5.97
mmol/l
1.17
131
1248
61
463
1.48
1.65
3.0
3.2
2.36
2.35
mmol/l
0.50
54
405
57
428
1.49
1.62
2.6
2.3
—
—
—
0
0
84
683
1.43
1.57
3.4
3.5
0.00
0.00
estimate
0.00
25
141
84
685
1.42
1.53
4.6
4.8
0.00
0.00
estimate
0.00
26
139
5
15
3.40
1.53
1.0
1.1
—
—
—
0
0
5
15
3.40
1.53
1.8
1.6
—
—
—
0
0
5
15
3.40
1.53
2.2
1.1
—
—
—
0
0
26
165
1.67
1.51
1.3
1.4
—
—
—
0
0
26
166
1.66
1.47
1.5
1.3
—
—
—
0
0
25
158
1.68
1.47
2.1
1.6
—
—
—
0
0
32
216
1.59
1.46
1.4
1.3
0.68
9.59
u/ml
—
8
91
19
111
1.80
1.46
1.3
1.5
—
—
—
0
0
19
112
1.78
1.42
1.3
1.3
—
—
—
0
0
33
227
1.56
1.40
1.4
1.3
49.86
37.32
iu/ml
—
10
78
84
698
1.38
1.33
3.4
3.6
0.00
0.00
estimate
0.00
28
133
168
1586
1.89
1.32
30.7
20.1
4.69
4.51
e12/l
1.68
163
1533
5
18
2.83
1.29
1.8
1.6
28.46
32.54
g/l
—
5
18
155
1437
1.57
1.27
5.7
5.0
2.66
2.75
mmol/l
0.64
145
1310
63
511
1.36
1.12
3.3
2.9
—
—
—
0
0
7
31
2.31
1.11
1.3
1.7
—
—
—
0
0
20
129
1.62
1.11
6.7
3.4
1.75
2.26
mmol/l
0.15
13
102
23
154
1.57
1.10
1.3
1.7
—
—
—
0
0
26
182
1.50
1.03
7.3
7.5
103.77
104.02
mmol/l
0.10
26
175
142
1311
1.39
1.02
22.2
14.8
41.30
40.31
%
0.46
96
960
48
379
1.36
1.00
3.5
3.8
0.00
0.00
estimate
0.00
26
134
5
23
2.21
0.98
2.8
2.7
—
—
—
0
0
5
23
2.21
0.98
2.0
1.7
—
—
—
0
0
11
62
1.82
0.96
1.3
1.0
—
—
—
0
0
158
1493
1.48
0.92
17.7
12.6
—
—
—
0
0
18
119
1.57
0.92
2.3
4.6
—
—
—
0
0
27
199
1.42
0.84
2.6
1.8
—
—
—
0
0
15
97
1.60
0.84
3.9
4.3
—
—
—
0
0
8
47
1.73
0.82
4.8
3.1
—
—
—
0
0
25
183
1.43
0.81
1.6
1.6
—
—
—
0
0
15
98
1.58
0.81
1.3
1.6
—
—
—
0
0
48
392
1.31
0.80
1.7
1.7
1.43
1.39
mmol/l
0.13
34
325
0
24
0.00
0.80
0.0
1.1
—
—
—
0
0
45
367
1.30
0.76
8.9
7.3
—
—
—
0
0
5
24
2.11
0.75
2.0
2.5
—
—
—
0
0
9
57
1.61
0.72
8.6
4.3
—
—
—
0
0
21
155
1.40
0.66
2.5
4.3
3.22
38.84
ug/l
0.71
16
128
18
129
1.44
0.66
2.2
1.7
—
—
—
0
0
10
63
1.62
0.63
3.2
3.6
—
—
—
0
0
33
268
1.28
0.58
3.3
3.6
12.23
175.95
ng/l
1.69
22
212
6
39
1.56
0.53
1.0
1.3
—
—
—
0
0
5
31
1.63
0.43
1.2
2.0
—
—
—
0
0
5
33
1.53
0.41
1.2
1.0
—
—
—
0
0
7
104
0.66
0.40
1.1
2.5
—
—
—
0
0
5
34
1.48
0.40
1.2
1.9
119.80
235.82
e6/l
—
5
28
5
34
1.48
0.40
1.2
1.8
1.00
2.69
e6/l
—
5
26
5
34
1.48
0.40
1.0
1.2
—
—
—
0
0
5
34
1.48
0.40
2.4
6.3
—
—
—
0
0
5
36
1.40
0.38
2.2
1.3
—
—
—
0
0
15
117
1.31
0.36
1.3
1.1
—
—
—
0
0
9
125
0.71
0.36
1.4
1.4
—
—
—
0
0
6
41
1.48
0.36
1.0
1.1
—
—
—
0
0
6
45
1.34
0.34
2.2
1.5
—
—
—
0
0
6
46
1.31
0.33
2.2
1.4
—
—
—
0
0
6
46
1.31
0.33
2.2
1.5
—
—
—
0
0
6
46
1.31
0.33
2.2
1.5
—
—
—
0
0
6
46
1.31
0.33
6.3
4.1
4.28
4.01
mmol/l
—
6
40
11
83
1.35
0.33
3.1
3.6
4.10
4.59
pmol/l
0.74
11
76
6
47
1.29
0.32
3.3
4.3
—
—
—
0
0
8
106
0.74
0.30
3.0
3.3
—
—
—
0
0
0
11
0.00
0.21
0.0
1.4
—
—
—
0
0
0
10
0.00
0.21
0.0
1.2
—
1.73
—
0
10
0
10
0.00
0.21
0.0
5.4
—
—
—
0
0
0
10
0.00
0.21
0.0
8.0
—
—
—
0
0
0
12
0.00
0.21
0.0
1.5
—
—
—
0
0
0
12
0.00
0.21
0.0
2.7
—
—
—
0
0
5
43
1.17
0.21
2.4
1.5
—
—
—
0
0
0
14
0.00
0.20
0.0
1.0
—
—
—
0
0
20
176
1.15
0.18
1.3
1.3
—
—
—
0
0
19
167
1.15
0.17
6.2
8.2
0.88
1.15
mmol/l
0.09
13
137
5
70
0.71
0.17
2.0
4.1
—
—
—
0
0
8
69
1.17
0.16
3.6
2.5
—
—
—
0
0
33
309
1.08
0.11
3.2
3.3
—
—
—
0
0
51
489
1.06
0.09
5.0
4.2
1.42
2.20
ug/l
1.50
44
433
5
48
1.04
0.09
1.8
1.6
—
—
—
0
0
15
136
1.11
0.09
2.3
1.5
—
—
—
0
0
6
57
1.05
0.08
1.2
1.8
—
—
—
0
0
6
58
1.04
0.08
15.3
8.6
—
—
—
0
0
5
62
0.80
0.08
1.2
1.3
—
—
—
0
0
9
88
1.02
0.07
1.2
1.2
—
—
—
0
0
9
104
0.86
0.06
2.6
1.8
—
—
—
0
0
23
240
0.95
0.03
2.0
1.9
—
—
—
0
0
13
127
1.03
0.00
1.4
1.4
—
—
—
0
0
30
295
1.02
0.00
2.6
2.8
0.69
0.81
ug/l
0.41
22
180
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.3
—
130.68
—
0
6
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.8
—
—
—
0
0
0
9
0.00
0.00
0.0
1.3
—
27.63
—
0
9
0
5
0.00
0.00
0.0
2.2
—
0.36
—
0
5
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
0
9
0.00
0.00
0.0
7.7
—
—
—
0
0
0
6
0.00
0.00
0.0
1.5
—
—
—
0
0
0
5
0.00
0.00
0.0
1.8
—
—
—
0
0
0
9
0.00
0.00
0.0
8.7
—
0.61
—
0
9
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
0
8
0.00
0.00
0.0
1.3
—
7.13
—
0
8
0
7
0.00
0.00
0.0
1.9
—
8.27
—
0
7
9
90
1.00
0.00
1.2
1.2
—
—
—
0
0
0
8
0.00
0.00
0.0
1.4
—
—
—
0
0
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
0
7
0.00
0.00
0.0
4.0
—
43.43
—
0
7
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
0
7
0.00
0.00
0.0
2.1
—
1.70
—
0
7

Mortality – FinRegistry

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

Relationships between endpoints

Index endpoint: R18_ABNORMALITY_RED_BLOOD_CELLS – Abnormality of red blood cells

GWS hits: -

This endpoint is excluded from FinRegistry analyses (omitted endpoint).