hematologic disease: A disease involving the hematopoietic system.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
2440 |
4. Check minimum number of eventsNone |
2440 |
5. Include endpoints |
2584 |
6. Filter based on genotype QC (FinnGen only) |
2584 |
Control definitions (FinnGen only)
- Control exclude
- D3_BLOODOTHER
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- D70-D77
- Name in latin
- Alii morbi sanguinis et organorum haematopoeticorum
Similar endpoints
↥List of similar endpoints to
Other diseases of blood and blood-forming organs
based on the number of shared cases.
Similar with more cases:
- Other diseases of blood and blood-forming organs, wide
- Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
- Any event in hilmo or specialist outpatient
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 17063 | 8307 | 8588 |
| Only index persons | 14250 | 7111 | 7139 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.24 | 0.24 | 0.24 |
| Only index persons | 0.27 | 0.26 | 0.27 |
| Median age at first event (years) | |||
| Whole population | 60.51 | 61.34 | 59.66 |
| Only index persons | 59.31 | 60.14 | 58.49 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 2584 | 1280 | 1304 |
| Unadjusted period prevalence (%) | 0.51 | 0.44 | 0.57 |
| Median age at first event (years) | 59.18 | 57.57 | 60.75 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 2343
- Matched controls
- 23428
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
XW000
NOMESCO Finland
Bone marrow biopsy
29.4
323.0
648
301
D75.2
ICD-10 Finland
Essential thrombocytosis
3456.6
323.0
826
*
L01XX05
ATC
hydroxycarbamide; oral
170.7
323.0
608
48
D75.1
ICD-10 Finland
Secondary polycythaemia
3092.0
323.0
706
*
117
Kela drug reimbursment
Leukaemia and other malignant diseases of the blood and bone marrow, and malignant diseases of the lymphatic tissue
34.3
323.0
750
317
D47.3
ICD-10 Finland
Essential (haemorrhagic) thrombocythaemia
150.9
323.0
509
43
D75.9
ICD-10 Finland
Disease of blood and blood-forming organs, unspecified
2301.9
323.0
652
*
D45
ICD-10 Finland
Polycythaemia vera
67.2
268.9
310
53
TNE25
NOMESCO Finland
Drill biopsy of bone marrow, pelvis
48.4
212.0
259
60
9962/3-C42.1
ICD-O-3
Essential thrombocythemia of bone marrow
237.4
192.6
196
9
D75.0
ICD-10 Finland
Familial erythrocytosis
604.3
172.6
169
*
D47.1
ICD-10 Finland
Chronic myeloproliferative disease
76.1
108.5
123
17
TPH00
NOMESCO Finland
Phlebotomy
62.8
107.2
125
21
L01XX35
ATC
anagrelide; oral
228.4
106.5
109
5
D75.8
ICD-10 Finland
Other specified diseases of blood and blood-forming organs
514.1
100.3
99
*
SPAT1074
SPAT
Venesection
56.4
95.3
113
21
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
3.5
91.0
494
1663
L03AB05
ATC
interferon alfa-2b; parenteral
48.1
79.6
97
21
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
3.3
56.9
311
1024
9960/3-C42.1
ICD-O-3
Myeloproliferative neoplasm, NOS, of bone marrow
123.1
56.1
60
5
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.0
54.3
1115
7327
9950/3-C42.1
ICD-O-3
Polycythemia vera of bone marrow
43.0
54.1
67
16
28900
ICD-8 Finland
Other disease of blood and blood-forming organs, Polycythaemia, secondary
+∞
43.9
42
*
L03AB04
ATC
interferon alfa-2a; parenteral
52.1
42.8
51
10
9961/3-C42.1
ICD-O-3
Primary myelofibrosis of bone marrow
47.3
42.1
51
11
M04AA01
ATC
allopurinol; systemic
2.4
42.0
394
1797
D72.8
ICD-10 Finland
Other specified disorders of white blood cells
66.9
40.2
46
7
R79.9
ICD-10 Finland
Abnormal finding of blood chemistry, unspecified
18.9
38.4
59
32
28998
ICD-8 Finland
Other disease of blood and blood-forming organs, Alii definiti
+∞
34.5
33
*
R79.8
ICD-10 Finland
Other specified abnormal findings of blood chemistry
15.3
34.4
57
38
B99
ICPC
Blood/lymph/spleen disease other
20.0
34.0
51
26
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
1.8
32.9
692
4364
174
Kela drug reimbursment
Ruxolitinib
86.3
30.8
34
*
28999
ICD-8 Finland
Other disease of blood and blood-forming organs, Other and unspecified
+∞
28.2
27
*
R71
ICD-10 Finland
Abnormality of red blood cells
33.2
27.8
36
11
D47.2
ICD-10 Finland
Monoclonal gammopathy of undetermined significance (MGUS)
7.9
27.3
63
82
C03CA01
ATC
furosemide; systemic
1.7
27.0
670
4398
374
Kela drug reimbursment
Ruxolitinib
97.9
26.7
29
*
Z2221
NOMESCO Finland
Medical doctor
1.7
25.8
638
4175
B01AB05
ATC
enoxaparin; parenteral
1.7
25.3
696
4693
ZXE00
NOMESCO Finland
One hour or less
1.6
25.2
882
6349
C07AB07
ATC
bisoprolol; oral
1.6
24.5
1073
8160
WW500
NOMESCO Finland
Blood transfusion
3.4
24.5
121
365
C92.0
ICD-10 Finland
Acute myeloblastic leukaemia [AML]
22.3
23.0
33
15
XX7BT
NOMESCO Finland
Radioactive phosphorus therapy
116.1
21.6
23
*
L01EJ01
ATC
ruxolitinib; oral
116.1
21.6
23
*
H02AB06
ATC
prednisolone; systemic
1.5
21.5
1019
7815
L01XE18
ATC
[U] ruxolitinib; oral
60.6
20.9
24
*
C92.1
ICD-10 Finland
Chronic myeloid leukaemia [CML], BCR/ABL-positive
37.5
20.8
26
7
A02BC02
ATC
pantoprazole; systemic
1.5
20.8
1424
11830
D70.89
ICD-10 Finland
Neutropenic splenomegaly
42.0
20.5
25
6
D46.7
ICD-10 Finland
Other myelodysplastic syndromes
32.8
20.2
26
8
212
Kela drug reimbursment
Gout
4.3
20.2
76
182
G03BA03
ATC
testosterone; systemic, rectal, sublingual, transdermal
2.4
19.8
170
730
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
1.8
19.8
405
2475
R50.9
ICD-10 Finland
Fever, unspecified
1.9
19.4
302
1681
Z3231
NOMESCO Finland
Registered nurse
1.6
19.2
606
4180
T90
ICPC
Diabetes non-insulin dependent
1.7
19.2
520
3445
D69.6
ICD-10 Finland
Thrombocytopenia, unspecified
5.1
19.1
60
119
N02AX02
ATC
tramadol; systemic, rectal
1.5
19.0
938
7188
L03AA04
ATC
NA
34.6
18.9
24
7
C03DA01
ATC
spironolactone; oral
2.0
18.7
261
1393
FB1BD
NOMESCO Finland
Extensive CT examination of arteria pulmonalis
2.2
18.4
189
886
I10
ICD-10 Finland
Essential (primary) hypertension
1.5
18.3
1289
10626
D47.9
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour of lymphoid, haematopoietic and related tissue, unspecified
17.7
18.2
28
16
B01AA03
ATC
warfarin; systemic
1.7
17.9
457
2968
Z3226
NOMESCO Finland
Physiotherapist
1.7
17.9
410
2583
ZY020
NOMESCO Finland
Telephone, letter or other consultation without direct patient contact
2.3
17.9
168
753
XF400
NOMESCO Finland
ECG with 12 standard connections
1.7
17.8
372
2282
B01AC14
ATC
[U] anagrelide; oral
+∞
17.7
17
*
Z01.8
ICD-10 Finland
Other specified special examinations
1.6
17.2
466
3077
E11.9
ICD-10 Finland
Type 2 diabetes mellitus, without complications
1.6
17.0
508
3440
I50.9
ICD-10 Finland
Heart failure, unspecified
1.8
17.0
307
1797
103
Kela drug reimbursment
Diabetes, insulin-treated
1.6
16.9
588
4137
SPAT1262
SPAT
Handing over of treatment supplies
1.7
16.9
417
2681
215
Kela drug reimbursment
Diabetes, non-insulin-treated
1.6
16.6
534
3682
R06.0
ICD-10 Finland
Dyspnoea
1.6
16.3
538
3729
D64.9
ICD-10 Finland
Anaemia, unspecified
1.9
16.2
235
1271
ZXE10
NOMESCO Finland
More than one and less than three hours
1.5
16.0
780
5903
G47.3
ICD-10 Finland
Sleep apnoea
1.6
15.9
470
3168
A10BA02
ATC
metformin; oral
1.5
15.5
599
4303
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
1.6
15.3
469
3188
TNE20
NOMESCO Finland
Bone marrow aspiration, pelvis
20.2
15.1
22
11
NEA10
NOMESCO Finland
Exploration of soft tissue of pelvis, percutaneous
14.0
15.0
25
18
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
1.7
14.9
337
2106
TPH04
NOMESCO Finland
Cathetrisation of vein
1.6
14.8
442
2981
R03AC02
ATC
salbutamol; inhalant
1.4
14.8
1071
8723
ZX120
NOMESCO Finland
Intravenous
2.0
14.6
205
1095
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
1.9
14.5
216
1179
D75
ICD-10 Finland
Other diseases of blood and blood-forming organs
150.9
14.5
15
*
ZXD05
NOMESCO Finland
Urgent procedure
1.5
14.2
642
4761
XW4XT
NOMESCO Finland
Biopsy of other inner organ with radiological guidance guidance
42.7
14.1
17
*
R03BB04
ATC
tiotropium bromide; inhalant
1.9
14.1
226
1267
I70.2
ICD-10 Finland
Atherosclerosis of arteries of extremities
1.9
14.0
210
1148
J96.1
ICD-10 Finland
Chronic respiratory failure
3.5
13.9
64
185
D70.82
ICD-10 Finland
Drug-induced neutropenia
30.2
13.9
18
6
T81.0
ICD-10 Finland
Haemorrhage and haematoma complicating a procedure, not elsewhere classified
2.2
13.8
148
708
C90.0
ICD-10 Finland
Multiple myeloma
5.6
13.6
39
71
D73.5
ICD-10 Finland
Infarction of spleen
+∞
13.5
13
*
D50.9
ICD-10 Finland
Iron deficiency anaemia, unspecified
2.1
13.5
157
777
D72.9
ICD-10 Finland
Disorder of white blood cells, unspecified
25.9
13.4
18
7
B28
ICPC
Limited function/disability (B)
9.1
13.2
27
30
J01DB01
ATC
cefalexin; oral
1.4
13.2
1774
16007
J18.9
ICD-10 Finland
Pneumonia, unspecified
1.5
12.9
480
3400
TPH07
NOMESCO Finland
Cathetrisation of artery
1.8
12.9
232
1352
D58.2
ICD-10 Finland
Other haemoglobinopathies
50.3
12.8
15
*
M79.6
ICD-10 Finland
Pain in limb
1.4
12.7
714
5500
WW200
NOMESCO Finland
Immunization
3.0
12.7
73
249
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.4
12.7
701
5386
189
Kela drug reimbursment
Imatinib
15.5
12.6
20
13
SPAT1250
SPAT
Comprehensive monitoring of chronic illness
1.5
12.4
581
4318
R4110
NOMESCO Finland
Physiotherapy
1.5
12.3
549
4037
A49.9
ICD-10 Finland
Bacterial infection, unspecified
1.8
12.3
218
1261
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
1.6
12.1
327
2142
J01MA12
ATC
levofloxacin; systemic
1.6
12.1
386
2634
UJF30
NOMESCO Finland
Ileoscopy through colon
1.8
12.1
209
1200
Z2446
NOMESCO Finland
Social worker
2.1
11.9
135
664
N06AX11
ATC
mirtazapine; oral
1.4
11.7
642
4909
E29.1
ICD-10 Finland
Testicular hypofunction
4.4
11.7
41
94
2890X
ICD-9 Finland
Other diseases of blood and blood-forming organs, Polycythaemia, secondary[ERYTHROCYTOSIS SECUNDARIA, NUD]
+∞
11.5
11
*
2898X
ICD-9 Finland
Other diseases of blood and blood-forming organs, Other specified diseases of blood and blood-forming organs
+∞
11.5
11
*
C09AA05
ATC
ramipril; oral
1.5
11.4
518
3816
N02BE01
ATC
paracetamol; systemic, rectal
1.4
11.4
1866
17137
C08CA01
ATC
amlodipine; oral
1.4
11.4
753
5951
E11.8
ICD-10 Finland
Type 2 diabetes mellitus, with unspecified complications
1.8
11.2
202
1177
WX408
NOMESCO Finland
General anesthesy, balanced
1.4
11.2
546
4075
R5140
NOMESCO Finland
Monitoring the use of the aid
1.7
11.2
222
1332
J01EE01
ATC
sulfamethoxazole and trimethoprim; systemic
2.1
11.2
125
611
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
1.9
11.1
174
967
D69.1
ICD-10 Finland
Qualitative platelet defects
20.1
11.1
16
8
GD1DD
NOMESCO Finland
High resolution CT examination of lungs
2.2
11.1
108
497
UJF32
NOMESCO Finland
Coloscopy
1.4
11.0
528
3930
DM1QA
NOMESCO Finland
Paranasal sinuses X-ray examination in one projection
2.4
10.9
93
401
I63.9
ICD-10 Finland
Cerebral infarction, unspecified
1.7
10.8
212
1270
G45.9
ICD-10 Finland
Transient cerebral ischaemic attack, unspecified
1.9
10.8
169
939
285
Kela drug reimbursment
Dulaglutide, exenatide, liraglutide, lixisenatide and semaglutide (adults)
2.2
10.8
108
503
J44.8
ICD-10 Finland
Other specified chronic obstructive pulmonary disease
1.7
10.7
216
1304
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
1.4
10.7
660
5139
R53
ICD-10 Finland
Malaise and fatigue
1.5
10.6
392
2765
R11
ICD-10 Finland
Nausea and vomiting
1.9
10.6
158
866
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
1.7
10.4
223
1367
2387X
ICD-9 Finland
Neoplasm of uncertain behaviour of other and unspecified sites and tissues, Other lymphatic and haematopoietic tissues[STATUS LYMPHO- ET MYELOPROLIFERATIVUS NUD]
+∞
10.4
10
*
9863/3-C42.1
ICD-O-3
Chronic myeloid leukemia, NOS, of bone marrow
+∞
10.4
10
*
9861/3-C42.1
ICD-O-3
Acute myeloid leukemia, NOS, of bone marrow
16.1
10.3
16
10
N02AJ06
ATC
codeine and paracetamol; systemic
1.4
10.3
741
5916
N05BA04
ATC
oxazepam; oral
1.4
10.3
482
3566
346
Kela drug reimbursment
Dulaglutide, exenatide, liraglutide, lixisenatide and semaglutide (adults)
2.2
10.2
97
442
C07AB02
ATC
metoprolol; systemic
1.5
10.1
436
3172
Z03.9
ICD-10 Finland
Observation for suspected disease or condition, unspecified
1.5
10.0
334
2297
L01XE01
ATC
[U] imatinib; oral
14.6
10.0
16
11
L04AD01
ATC
ciclosporin; systemic
3.5
9.9
44
126
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
1.3
9.8
1005
8467
N07BA03
ATC
varenicline; oral
2.1
9.7
106
514
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
1.3
9.7
925
7702
I26.9
ICD-10 Finland
Pulmonary embolism without mention of acute cor pulmonale
2.1
9.7
112
555
XPX99
NOMESCO Finland
Other diagnostic examination of periferal vessel
1.9
9.7
145
794
J01FF01
ATC
clindamycin; systemic
1.4
9.6
541
4132
ZXE06
NOMESCO Finland
Procedure duration 50 to 59 minutes
2.1
9.6
102
488
A10BH01
ATC
sitagliptin; oral
1.7
9.5
192
1159
E66.2
ICD-10 Finland
Extreme obesity with alveolar hypoventilation
4.1
9.4
35
86
B04
ICPC
Blood symptom/complaint
6.6
9.4
23
35
122
Kela drug reimbursment
Aplastic anaemia
100.4
9.4
10
*
D47.0
ICD-10 Finland
Histiocytic and mast cell tumours of uncertain and unknown behaviour
30.1
9.4
12
*
2899X
ICD-9 Finland
Other diseases of blood and blood-forming organs, Unspecified diseases of blood and blood-forming organs
+∞
9.4
9
*
S97
ICPC
Chronic ulcer skin
2.0
9.3
120
620
TFP20
NOMESCO Finland
Cardiodefibrillation
1.8
9.3
155
880
E11
ICD-10 Finland
Type 2 diabetes mellitus
1.5
9.3
319
2210
A10AE04
ATC
insulin glargine; parenteral
1.7
9.3
189
1143
WX002
NOMESCO Finland
Sedation and analgesia
1.5
9.2
398
2892
9732/3-C42.1
ICD-O-3
Plasma cell myeloma of bone marrow
5.5
9.2
26
48
AA1AD
NOMESCO Finland
CT of head and brain
1.4
9.1
474
3566
Z2445
NOMESCO Finland
Psychologist
2.5
9.1
70
289
R07.4
ICD-10 Finland
Chest pain, unspecified
1.4
9.0
529
4066
H02AB09
ATC
hydrocortisone; systemic
2.8
9.0
54
193
B01AB10
ATC
tinzaparin; parenteral
1.9
9.0
135
741
ZY010
NOMESCO Finland
Hospital outpatient
2.2
8.9
86
396
205
Kela drug reimbursment
Chronic hypertension
1.4
8.9
583
4562
N05CF01
ATC
zopiclone; oral
1.4
8.9
644
5124
SPAT1249
SPAT
Treatment-related counselling outside office
1.3
8.9
785
6443
315
Kela drug reimbursment
Clopidogrel
4.1
8.8
33
82
I69.3
ICD-10 Finland
Sequelae of cerebral infarction
1.8
8.8
149
854
C08CA05
ATC
nifedipine; systemic
1.9
8.7
135
749
Z76.9
ICD-10 Finland
Person encountering health services in unspecified circumstances
1.8
8.7
146
833
SPAT1306
SPAT
Counselling and guidance related to nutrition and weight management
1.5
8.6
270
1829
WX892
NOMESCO Finland
Monitored bed care
1.8
8.6
156
913
B01AC04
ATC
clopidogrel; oral
1.5
8.6
319
2242
L01EA01
ATC
imatinib; oral (bcr-abl tyrosine kinase inhibitors)
16.3
8.5
13
8
Y83
ICD-10 Finland
Surgical operation and other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
1.8
8.5
148
853
C91.1
ICD-10 Finland
Chronic lymphocytic leukaemia of B-cell type
4.9
8.5
26
53
TPH20
NOMESCO Finland
Insertion of central venous catheter through subclavian or brachiocephalic vein
2.6
8.5
58
223
WX402
NOMESCO Finland
General anaesthesia
1.5
8.4
314
2212
XF600
NOMESCO Finland
Bloodpressure measurement
1.9
8.3
126
692
Q21.81
ICD-10 Finland
Eisenmenger's syndrome
+∞
8.3
8
*
127
Kela drug reimbursment
Transplant complication
3.7
8.3
34
92
R72
ICD-10 Finland
Abnormality of white blood cells, not elsewhere classified
8.6
8.3
17
20
J01DA01
ATC
[U] cefalexin; systemic
1.3
8.3
1291
11423
E66.01
ICD-10 Finland
Obesity due to excess calories
1.8
8.3
137
780
N18.9
ICD-10 Finland
Chronic kidney disease, unspecified
1.9
8.2
116
625
XG466
NOMESCO Finland
Sleep oxymetry
2.3
8.2
72
316
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
1.4
8.2
578
4572
J01MA02
ATC
ciprofloxacin; systemic
1.3
8.2
778
6436
Z03.89
ICD-10 Finland
Observation for other suspected diseases and conditions
1.6
8.1
231
1530
X59
ICD-10 Finland
Exposure to unspecified factor
1.4
8.1
347
2513
WX110
NOMESCO Finland
Local anesthesy
1.3
8.1
1381
12350
Z71.3
ICD-10 Finland
Dietary counselling and surveillance
2.0
8.0
96
486
I50.0
ICD-10 Finland
Congestive heart failure
1.8
8.0
142
823
N05CF02
ATC
zolpidem; oral
1.5
8.0
334
2407
A10BK03
ATC
empagliflozin; oral
1.8
8.0
140
810
ZXE20
NOMESCO Finland
More than three and less than five hours
1.5
8.0
266
1828
SPAT1148
SPAT
Treatment of chronic ulcer or burn
1.5
8.0
280
1945
M10.9
ICD-10 Finland
Gout, unspecified
1.8
8.0
138
796
A46
ICD-10 Finland
Erysipelas
1.5
8.0
284
1978
E23.04
ICD-10 Finland
Hypogonadotropic hypogonadism
4.4
7.9
27
62
C01AA05
ATC
digoxin; systemic
1.7
7.9
161
978
J01CA04
ATC
amoxicillin; systemic
1.3
7.8
1651
15145
A12BA01
ATC
potassium chloride; oral
2.0
7.8
92
463
R04.0
ICD-10 Finland
Epistaxis
1.7
7.8
150
894
JN3BD
NOMESCO Finland
Extensive abdominal CT
1.6
7.8
212
1390
N03AX16
ATC
pregabalin; oral
1.4
7.7
456
3500
K92.1
ICD-10 Finland
Melaena
2.0
7.7
100
523
I48
ICD-10 Finland
Atrial fibrillation and flutter
1.4
7.7
453
3473
D72.1
ICD-10 Finland
Eosinophilia
45.1
7.7
9
*
J01CE02
ATC
phenoxymethylpenicillin; oral
1.3
7.7
1384
12417
A04AA01
ATC
ondansetron; systemic, rectal
1.9
7.7
117
647
KH1AE
NOMESCO Finland
Urinary tract ultrasound examination
1.9
7.6
111
606
J44.0
ICD-10 Finland
Chronic obstructive pulmonary disease with acute lower respiratory infection
2.0
7.6
94
480
A10BJ02
ATC
liraglutide; parenteral
2.5
7.6
56
226
C03EA01
ATC
hydrochlorothiazide and potassium-sparing agents; oral
1.5
7.6
305
2181
N06AA09
ATC
amitriptyline; systemic
1.6
7.5
193
1244
TDW99
NOMESCO Finland
Other minor procedure in surgery of ear, nose and larynx
2.3
7.5
63
274
121
Kela drug reimbursment
Severe hypofunction of sexual glands
2.8
7.5
45
163
B86
ICPC
OTHER HAEMATOLOGICAL ABNORMALITY
80.3
7.4
8
*
B03XA02
ATC
darbepoetin alfa; parenteral
2.9
7.4
43
151
201
Kela drug reimbursment
Chronic cardiac insufficiency
1.9
7.3
100
532
D73.0
ICD-10 Finland
Hyposplenism
+∞
7.3
7
*
A10BJ06
ATC
semaglutide; parenteral
2.3
7.3
66
296
PG1DE
NOMESCO Finland
Other extensive ultrasound examination of artery
2.0
7.1
89
460
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
1.5
7.1
224
1521
WX723
NOMESCO Finland
CPAP therapy
2.2
7.1
72
340
R03AL09
ATC
formoterol, glycopyrronium bromide and beclometasone; inhalant
2.9
7.1
41
144
Y28
ICPC
Limited function/disability (Y)
5.3
7.1
20
38
A10AB05
ATC
insulin aspart; parenteral (insulins and analog. for injection, fast-acting)
1.7
7.0
140
845
C02AC05
ATC
moxonidine; oral
1.9
7.0
94
497
J44.9
ICD-10 Finland
Chronic obstructive pulmonary disease, unspecified
1.9
7.0
92
483
A10BK01
ATC
dapagliflozin; oral
1.9
7.0
92
485
C10AA01
ATC
simvastatin; oral
1.3
7.0
885
7565
D69.3
ICD-10 Finland
Idiopathic thrombocytopenic purpura
4.9
7.0
21
43
R03AL06
ATC
olodaterol and tiotropium bromide; inhalant
2.9
7.0
40
139
R51.80
ICD-10 Finland
Headache
1.5
7.0
248
1730
E66.8
ICD-10 Finland
Other obesity
1.9
6.9
93
491
JN4BD
NOMESCO Finland
Extensive body CT
1.5
6.9
209
1405
ZXE11
NOMESCO Finland
Procedure duration 60 to 89 minutes
1.9
6.9
99
537
B01AB04
ATC
dalteparin; parenteral
1.9
6.9
97
524
J44
ICD-10 Finland
Other chronic obstructive pulmonary disease
2.5
6.9
49
196
L28
ICPC
Limited function/disability (L)
1.4
6.8
296
2147
K92.2
ICD-10 Finland
Gastrointestinal haemorrhage, unspecified
2.3
6.8
58
254
ZXD10
NOMESCO Finland
Scheduled procedure
1.3
6.8
751
6302
RS220
NOMESCO Finland
NA
3.4
6.8
30
88
207
Kela drug reimbursment
Chronic arrhythmias
1.4
6.8
287
2071
D04.3
ICD-10 Finland
Carcinoma in situ: Skin of other and unspecified parts of face
2.8
6.8
41
150
C95.0
ICD-10 Finland
Acute leukaemia of unspecified cell type
40.2
6.8
8
*
K80.2
ICD-10 Finland
Calculus of gallbladder without cholecystitis
1.5
6.7
211
1431
J20.9
ICD-10 Finland
Acute bronchitis, unspecified
1.4
6.6
326
2417
N17.9
ICD-10 Finland
Acute renal failure, unspecified
2.0
6.6
76
380
D50.0
ICD-10 Finland
Iron deficiency anaemia secondary to blood loss (chronic)
2.2
6.6
64
299
R03AK07
ATC
formoterol and budesonide; inhalant
1.4
6.5
339
2539
E66.00
ICD-10 Finland
Metabolic syndrome
1.8
6.5
104
587
8070/3-C44.9
ICD-O-3
Squamous cell carcinoma, NOS, of skin, NOS
3.2
6.5
32
102
SPAT1222
SPAT
Counselling/guidance promoting independent living
1.4
6.5
277
2001
TPH00
SPAT
NA
70.0
6.4
7
*
J44.1
ICD-10 Finland
Chronic obstructive pulmonary disease with acute exacerbation, unspecified
2.1
6.4
66
317
A06AD11
ATC
lactulose; oral
1.4
6.4
266
1912
316
Kela drug reimbursment
Imatinib
14.3
6.4
10
7
3AC01
NOMESCO Finland
NA
3.5
6.4
27
77
WX780
NOMESCO Finland
Remote monitoring CPAP
2.0
6.4
74
371
PJ2AE
NOMESCO Finland
Lymphnode ultrasound examination
3.8
6.4
25
67
XF402
NOMESCO Finland
ECG with work load test
1.5
6.4
221
1531
XF603
NOMESCO Finland
Direct intraarterial blood pressure measurement
2.0
6.3
74
373
K57.3
ICD-10 Finland
Diverticular disease of large intestine without perforation or abscess
1.4
6.3
334
2514
O99.1
ICD-10 Finland
Other diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism complicating pregnancy, childbirth and the puerperium
9.3
6.3
12
13
D68.8
ICD-10 Finland
Other specified coagulation defects
4.0
6.3
23
58
I80.3
ICD-10 Finland
Phlebitis and thrombophlebitis of lower extremities, unspecified
2.0
6.3
71
352
I26.0
ICD-10 Finland
Pulmonary embolism with mention of acute cor pulmonale
2.6
6.3
43
170
ZXE05
NOMESCO Finland
Procedure duration 40 to 49 minutes
1.8
6.3
101
571
N05BA01
ATC
diazepam; systemic, rectal
1.4
6.2
253
1812
A02BC05
ATC
esomeprazole; systemic
1.3
6.2
786
6690
XW000
SPAT
NA
26.7
6.2
8
*
A02BC01
ATC
omeprazole; systemic
1.3
6.2
522
4218
J06.9
ICD-10 Finland
Acute upper respiratory infection, unspecified
1.3
6.2
737
6228
F32.9
ICD-10 Finland
Depressive episode, unspecified
1.5
6.2
202
1382
I48.9
ICD-10 Finland
Atrial fibrillation and atrial flutter, unspecified
1.8
6.2
101
576
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
1.4
6.2
287
2108
TKC20
NOMESCO Finland
Catheterisation of bladder
1.6
6.2
135
838
ICB01
NOMESCO Finland
Psychiatric treatment plan, standard
2.8
6.2
36
128
C08CA02
ATC
felodipine; oral
1.5
6.2
180
1202
ZX108
NOMESCO Finland
Inhalation
5.0
6.2
18
36
A91
ICPC
Abnormal result investigation NOS
1.9
6.2
81
427
M03BC01
ATC
orphenadrine (citrate); systemic
1.3
6.1
413
3230
E78.5
ICD-10 Finland
Hyperlipidaemia, unspecified
1.5
6.1
191
1294
L30.9
ICD-10 Finland
Dermatitis, unspecified
1.4
6.1
311
2322
M54.5
ICD-10 Finland
Low back pain
1.3
6.1
605
4993
160
Kela drug reimbursment
exenatide
2.5
6.1
45
185
KA3AT
NOMESCO Finland
Biopsy of kidney with ultrasound guidance
3.2
6.1
29
91
WX2DD
NOMESCO Finland
Low-dose CT of skeleton in whole body
12.5
6.1
10
8
J01MA14
ATC
moxifloxacin; systemic
1.6
6.1
159
1032
E11.7
ICD-10 Finland
Type 2 diabetes mellitus, with multiple complications
1.8
6.1
98
557
E66.9
ICD-10 Finland
Obesity, unspecified
2.1
6.1
63
304
P01AB01
ATC
metronidazole; oral, rectal
1.3
6.1
732
6193
FM1BE
NOMESCO Finland
Cardiac ultrasound examination through oesophagus
1.7
6.0
120
726
Mortality – FinRegistry
↥Association
Association between endpoint D3_OTHERBLOOD and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| D3_OTHERBLOOD | 1.985 [1.78, 2.22] | < 0.001 |
| Birth year | 0.996 [0.99, 1.0] | 0.293 |
During the follow-up period (1.1.1998 — 31.12.2019), 1658 out of 6103 females with D3_OTHERBLOOD died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| D3_OTHERBLOOD | 1.825 [1.62, 2.05] | < 0.001 |
| Birth year | 0.986 [0.98, 1.0] | 0.004 |
During the follow-up period (1.1.1998 — 31.12.2019), 1754 out of 6045 males with D3_OTHERBLOOD died.
Mortality risk
Mortality risk for people of age
years, who have D3_OTHERBLOOD.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.216% | 0.396% |
| 5 | 1.289% | 2.196% |
| 10 | 3.139% | 5.364% |
| 15 | 5.656% | 9.533% |
| 20 | 10.057% | 16.307% |
Relationships between endpoints
↥Index endpoint: D3_OTHERBLOOD – Other diseases of blood and blood-forming organs
GWS hits: 6
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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