hematologic disease: A disease involving the hematopoietic system.
Other and unspecified diseases of blood and blood-forming organs
DOID EFO Endpoint Browser PheWeb
D3_BLOODNAS
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
890 |
4. Check minimum number of eventsNone |
890 |
5. Include endpointsNone |
890 |
6. Filter based on genotype QC (FinnGen only) |
890 |
Control definitions (FinnGen only)
- Control exclude
- D3_BLOODOTHER
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
Similar endpoints
↥List of similar endpoints to
Other and unspecified diseases of blood and blood-forming organs
based on the number of shared cases.
Similar with more cases:
- Other diseases of blood and blood-forming organs
- Other diseases of blood and blood-forming organs, wide
- Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 6321 | 3318 | 2939 |
| Only index persons | 5103 | 2725 | 2378 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.09 | 0.10 | 0.08 |
| Only index persons | 0.10 | 0.10 | 0.09 |
| Median age at first event (years) | |||
| Whole population | 59.07 | 58.15 | 60.11 |
| Only index persons | 57.37 | 55.93 | 59.01 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 890 | 480 | 410 |
| Unadjusted period prevalence (%) | 0.17 | 0.16 | 0.18 |
| Median age at first event (years) | 58.87 | 56.64 | 61.48 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 806
- Matched controls
- 8060
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
D75.9
ICD-10 Finland
Disease of blood and blood-forming organs, unspecified
10423.5
323.0
644
*
XW000
NOMESCO Finland
Bone marrow biopsy
49.2
258.1
314
103
117
Kela drug reimbursment
Leukaemia and other malignant diseases of the blood and bone marrow, and malignant diseases of the lymphatic tissue
29.2
171.3
237
113
TNE25
NOMESCO Finland
Drill biopsy of bone marrow, pelvis
93.2
150.3
164
22
L01XX05
ATC
hydroxycarbamide; oral
87.2
125.2
138
19
D47.3
ICD-10 Finland
Essential (haemorrhagic) thrombocythaemia
130.1
124.3
131
12
D75.8
ICD-10 Finland
Other specified diseases of blood and blood-forming organs
+∞
104.5
98
*
D75.2
ICD-10 Finland
Essential thrombocytosis
284.8
100.2
100
*
D45
ICD-10 Finland
Polycythaemia vera
51.8
73.5
88
19
9962/3-C42.1
ICD-O-3
Essential thrombocythemia of bone marrow
144.4
51.5
54
*
D75.1
ICD-10 Finland
Secondary polycythaemia
+∞
46.3
44
*
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
4.2
45.8
197
570
TPH00
NOMESCO Finland
Phlebotomy
59.4
38.7
45
8
28998
ICD-8 Finland
Other disease of blood and blood-forming organs, Alii definiti
+∞
34.6
33
*
D47.1
ICD-10 Finland
Chronic myeloproliferative disease
75.1
32.1
36
5
SPAT1074
SPAT
Venesection
62.7
31.3
36
6
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.4
29.5
416
2511
WW500
NOMESCO Finland
Blood transfusion
7.4
28.7
70
102
28999
ICD-8 Finland
Other disease of blood and blood-forming organs, Other and unspecified
+∞
28.3
27
*
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
3.7
25.1
120
367
D64.9
ICD-10 Finland
Anaemia, unspecified
3.3
22.1
121
409
D75.0
ICD-10 Finland
Familial erythrocytosis
+∞
22.0
21
*
9950/3-C42.1
ICD-O-3
Polycythemia vera of bone marrow
64.4
22.0
25
*
9960/3-C42.1
ICD-O-3
Myeloproliferative neoplasm, NOS, of bone marrow
225.8
21.7
22
*
D72.8
ICD-10 Finland
Other specified disorders of white blood cells
49.4
20.2
24
5
C92.0
ICD-10 Finland
Acute myeloblastic leukaemia [AML]
59.1
20.0
23
*
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.2
19.8
266
1492
D70.89
ICD-10 Finland
Neutropenic splenomegaly
64.7
16.8
19
*
D69.6
ICD-10 Finland
Thrombocytopenia, unspecified
8.3
15.9
35
44
TPH04
NOMESCO Finland
Cathetrisation of vein
2.2
15.8
196
1046
XF400
NOMESCO Finland
ECG with 12 standard connections
2.3
15.2
165
825
D46.7
ICD-10 Finland
Other myelodysplastic syndromes
32.4
14.9
19
6
C92.1
ICD-10 Finland
Chronic myeloid leukaemia [CML], BCR/ABL-positive
32.4
14.9
19
6
L03AB05
ATC
interferon alfa-2b; parenteral
22.7
14.3
20
9
ZX120
NOMESCO Finland
Intravenous
2.7
14.2
102
410
C90.0
ICD-10 Finland
Multiple myeloma
9.3
13.3
27
30
189
Kela drug reimbursment
Imatinib
50.8
12.9
15
*
R4110
NOMESCO Finland
Physiotherapy
1.9
12.5
229
1404
WW200
NOMESCO Finland
Immunization
5.1
12.5
39
80
M04AA01
ATC
allopurinol; systemic
2.3
12.3
122
582
9732/3-C42.1
ICD-O-3
Plasma cell myeloma of bone marrow
11.3
12.1
22
20
L03AA02
ATC
filgrastim; parenteral
5.4
11.6
34
65
2898X
ICD-9 Finland
Other diseases of blood and blood-forming organs, Other specified diseases of blood and blood-forming organs
+∞
11.5
11
*
A49.9
ICD-10 Finland
Bacterial infection, unspecified
2.4
11.5
105
481
WX002
NOMESCO Finland
Sedation and analgesia
2.0
11.5
174
991
H02AB06
ATC
prednisolone; systemic
1.7
11.4
378
2772
C03CA01
ATC
furosemide; systemic
1.8
11.4
240
1534
R79.9
ICD-10 Finland
Abnormal finding of blood chemistry, unspecified
15.3
11.3
18
12
WX892
NOMESCO Finland
Monitored bed care
2.7
11.0
76
298
L01XX35
ATC
anagrelide; oral
43.9
10.9
13
*
D47.2
ICD-10 Finland
Monoclonal gammopathy of undetermined significance (MGUS)
6.9
10.4
25
37
374
Kela drug reimbursment
Ruxolitinib
+∞
10.4
10
*
174
Kela drug reimbursment
Ruxolitinib
+∞
10.4
10
*
122
Kela drug reimbursment
Aplastic anaemia
+∞
10.4
10
*
L01EJ01
ATC
ruxolitinib; oral
+∞
10.4
10
*
R11
ICD-10 Finland
Nausea and vomiting
2.7
10.4
73
290
Z01.8
ICD-10 Finland
Other specified special examinations
1.9
10.1
180
1083
R50.9
ICD-10 Finland
Fever, unspecified
2.1
10.0
122
636
WX402
NOMESCO Finland
General anaesthesia
2.0
9.9
134
729
D50.9
ICD-10 Finland
Iron deficiency anaemia, unspecified
2.6
9.7
71
286
L01EA01
ATC
imatinib; oral (bcr-abl tyrosine kinase inhibitors)
55.7
9.7
11
*
L01XE01
ATC
[U] imatinib; oral
55.7
9.7
11
*
D72.9
ICD-10 Finland
Disorder of white blood cells, unspecified
101.2
9.4
10
*
NEA10
NOMESCO Finland
Exploration of soft tissue of pelvis, percutaneous
17.8
9.4
14
8
L04AD01
ATC
ciclosporin; systemic
5.7
9.4
26
47
L01XE18
ATC
[U] ruxolitinib; oral
+∞
9.4
9
*
2899X
ICD-9 Finland
Other diseases of blood and blood-forming organs, Unspecified diseases of blood and blood-forming organs
+∞
9.4
9
*
J01EE01
ATC
sulfamethoxazole and trimethoprim; systemic
2.8
9.3
59
222
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
2.4
9.2
80
355
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
1.9
9.2
150
870
WX408
NOMESCO Finland
General anesthesy, balanced
1.7
9.2
210
1366
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
1.7
9.1
260
1797
PG1DE
NOMESCO Finland
Other extensive ultrasound examination of artery
3.1
9.1
49
166
L03AB04
ATC
interferon alfa-2a; parenteral
37.1
9.0
11
*
9961/3-C42.1
ICD-O-3
Primary myelofibrosis of bone marrow
37.1
9.0
11
*
D47.9
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour of lymphoid, haematopoietic and related tissue, unspecified
24.3
8.9
12
5
C91.1
ICD-10 Finland
Chronic lymphocytic leukaemia of B-cell type
8.7
8.8
18
21
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
2.8
8.8
56
211
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
2.2
8.6
84
399
UJF92
NOMESCO Finland
Capsular endoscopy
4.8
8.5
27
58
I63.9
ICD-10 Finland
Cerebral infarction, unspecified
2.2
8.5
90
443
TPH07
NOMESCO Finland
Cathetrisation of artery
2.1
8.3
91
454
UJF32
NOMESCO Finland
Coloscopy
1.7
8.3
199
1304
J01MA12
ATC
levofloxacin; systemic
1.8
8.2
147
878
XF600
NOMESCO Finland
Bloodpressure measurement
2.6
8.2
60
246
C07AB07
ATC
bisoprolol; oral
1.5
8.2
366
2816
UJF30
NOMESCO Finland
Ileoscopy through colon
2.2
8.1
78
368
R72
ICD-10 Finland
Abnormality of white blood cells, not elsewhere classified
22.3
8.0
11
5
B01AB05
ATC
enoxaparin; parenteral
1.6
8.0
240
1672
FB1BD
NOMESCO Finland
Extensive CT examination of arteria pulmonalis
2.3
7.9
70
316
B99
ICPC
Blood/lymph/spleen disease other
10.9
7.8
14
13
316
Kela drug reimbursment
Imatinib
45.4
7.7
9
*
JN4BD
NOMESCO Finland
Extensive body CT
2.0
7.5
91
472
A02BC02
ATC
pantoprazole; systemic
1.5
7.5
492
4099
C03DA01
ATC
spironolactone; oral
2.1
7.5
89
459
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
1.8
7.4
129
762
D73.0
ICD-10 Finland
Hyposplenism
+∞
7.3
7
*
ZXA10
NOMESCO Finland
Bilateral
1.7
7.2
145
899
WX404
NOMESCO Finland
Intravenous generell anesthesy
1.7
7.2
157
998
N02AX02
ATC
tramadol; systemic, rectal
1.5
7.2
320
2439
9861/3-C42.1
ICD-O-3
Acute myeloid leukemia, NOS, of bone marrow
30.3
7.2
9
*
D59.1
ICD-10 Finland
Other autoimmune haemolytic anaemias
30.3
7.2
9
*
R53
ICD-10 Finland
Malaise and fatigue
1.7
7.1
147
917
9823/3-C42.1
ICD-O-3
B-cell chronic lymphocytic leukemia/small lymphocytic lymphoma of bone marrow
12.2
7.1
12
10
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
1.6
7.1
227
1600
Z76.9
ICD-10 Finland
Person encountering health services in unspecified circumstances
2.3
7.1
62
280
KH1AE
NOMESCO Finland
Urinary tract ultrasound examination
2.5
7.1
53
221
TPH20
NOMESCO Finland
Insertion of central venous catheter through subclavian or brachiocephalic vein
3.6
6.8
29
83
ZX108
NOMESCO Finland
Inhalation
11.0
6.8
12
11
XPX99
NOMESCO Finland
Other diagnostic examination of periferal vessel
2.3
6.8
60
273
I70.2
ICD-10 Finland
Atherosclerosis of arteries of extremities
2.0
6.8
80
412
R06.0
ICD-10 Finland
Dyspnoea
1.6
6.8
193
1321
WD515
NOMESCO Finland
Demanding therapy of malignancy with enzyme inhibitors and similar treatments
12.4
6.6
11
9
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
1.8
6.5
124
755
TK800
NOMESCO Finland
Hemodialysis
4.3
6.5
22
52
9863/3-C42.1
ICD-O-3
Chronic myeloid leukemia, NOS, of bone marrow
70.4
6.4
7
*
6BA02
NOMESCO Finland
NA
70.4
6.4
7
*
127
Kela drug reimbursment
Transplant complication
5.0
6.4
19
39
D64.8
ICD-10 Finland
Other specified anaemias
5.2
6.3
18
35
D46.9
ICD-10 Finland
Myelodysplastic syndrome, unspecified
9.3
6.3
12
13
D70.82
ICD-10 Finland
Drug-induced neutropenia
+∞
6.3
6
*
TNE20
NOMESCO Finland
Bone marrow aspiration, pelvis
26.9
6.2
8
*
B03XA02
ATC
darbepoetin alfa; parenteral
4.5
6.2
20
45
M79.6
ICD-10 Finland
Pain in limb
1.5
6.2
254
1889
E86
ICD-10 Finland
Volume depletion
3.9
6.1
23
60
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
1.5
6.1
336
2653
G45.9
ICD-10 Finland
Transient cerebral ischaemic attack, unspecified
2.1
6.1
64
314
B01AB10
ATC
tinzaparin; parenteral
2.2
6.0
55
255
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
272
94
41.23
307.65
1.8
1.7
—
—
—
0
0
462
775
11.32
297.87
8.2
3.7
257.0
247.5
u/l
0.34
454
737
202
112
23.04
260.24
1.5
1.2
47.0
33.0
u/l
0.40
178
102
421
796
9.14
238.34
4.1
2.4
1.9
1.8
%
0.28
389
719
173
83
25.63
236.31
1.0
1.0
—
—
—
0
0
344
984
5.07
115.06
3.5
2.4
24.6
22.4
%
1.57
310
841
694
3459
5.57
111.14
14.9
5.7
28.4
27.6
%
0.92
667
3224
683
3417
5.29
107.25
14.2
5.5
56.4
57.4
%
1.33
653
3198
345
1046
4.75
106.12
3.4
2.4
2.3
2.3
g/l
0.16
330
972
352
1141
4.45
98.10
3.5
2.4
13.7
12.7
umol/l
1.31
338
1053
166
314
6.27
86.88
3.0
1.8
1.2
1.5
g/l
3.23
149
275
138
216
7.38
86.81
5.5
2.7
0.1
0.0
g/l
0.24
130
204
143
238
6.97
84.88
5.4
3.0
1.8
1.1
g/l
0.83
132
218
722
4184
4.84
82.87
21.7
8.5
4.6
4.1
e9/l
2.77
651
3658
87
81
11.80
82.12
2.9
2.1
32.7
33.2
pg
0.34
87
81
130
204
7.29
81.43
5.3
2.7
0.0
0.0
g/l
0.00
122
192
127
202
7.17
78.48
5.4
2.7
0.0
0.0
g/l
0.00
122
191
145
265
6.34
78.28
5.4
2.6
3.1
3.2
g/l
0.01
124
216
132
228
6.62
75.29
5.2
2.6
37.9
37.5
g/l
0.29
123
202
146
285
5.93
73.44
5.4
2.6
3.8
3.8
g/l
0.02
124
213
146
285
5.93
73.44
5.4
2.6
7.0
7.4
g/l
1.45
124
223
146
285
5.93
73.44
5.4
2.6
—
—
—
0
0
138
263
6.03
71.11
5.2
2.6
10.9
10.5
g/l
0.32
124
234
125
225
6.30
68.22
5.9
3.9
54.5
82.8
mg/l
0.46
111
184
425
1907
3.35
68.13
4.6
2.6
2415.4
7774.4
umol/l
2.17
392
1649
125
226
6.27
67.90
5.9
3.9
41.4
42.7
mg/l
0.03
111
186
119
205
6.55
67.84
3.2
2.2
90.4
89.9
%
0.07
111
194
123
221
6.30
67.22
5.9
3.8
11.8
1.9
ratio
—
7
24
208
601
4.21
64.86
4.4
3.0
66.8
66.7
g/l
0.04
194
553
191
546
4.18
60.12
3.3
2.8
10.8
10.9
g/l
0.02
176
497
629
3824
3.20
55.45
11.1
6.0
11.2
11.3
umol/l
0.16
614
3639
49
37
13.96
52.30
1.7
1.4
—
—
—
0
0
49
37
13.96
52.30
1.7
1.4
—
—
—
0
0
381
1819
2.91
51.47
3.0
2.1
3.5
3.0
mg/l
1.22
326
1543
94
168
6.14
51.31
1.6
1.6
—
—
—
0
0
554
3311
2.78
47.16
9.7
6.0
1.2
1.2
mmol/l
0.69
522
2998
523
3055
2.73
46.28
5.1
2.7
176.7
133.9
ug/l
0.95
492
2810
218
815
3.22
44.69
6.0
2.7
6.2
8.2
umol/l
1.94
194
715
529
3151
2.67
44.28
8.4
4.7
35.3
35.5
g/l
0.35
501
2942
243
977
3.05
43.85
7.7
5.5
1.1
1.0
mmol/l
0.69
233
897
31
14
22.91
42.15
1.1
1.5
—
—
—
0
0
576
3644
2.65
41.52
10.8
6.8
1.2
1.2
mmol/l
0.07
475
3096
88
194
4.92
37.93
1.3
1.3
—
—
—
0
0
71
138
5.50
35.27
4.9
3.5
58.2
58.7
%
0.10
71
138
368
2004
2.43
34.91
4.2
3.2
0.7
0.5
e6/l
0.63
292
1526
62
107
6.15
34.87
1.4
1.4
83.4
108.1
u/ml
—
8
19
748
5644
3.04
33.99
16.3
7.3
81.4
78.3
u/l
1.26
724
5290
248
1136
2.64
33.93
3.7
2.0
30.3
29.7
s
0.84
239
1099
67
134
5.33
32.22
3.7
3.2
5.0
4.5
e9/l
0.58
67
134
425
2621
2.19
28.43
4.1
3.3
—
—
—
0
0
241
1178
2.43
28.07
3.6
3.0
1.9
2.4
e6/l
0.54
143
669
36
43
8.68
28.04
1.2
1.3
—
—
—
0
0
162
656
2.80
27.76
2.8
2.3
35.3
33.9
u/l
0.12
143
550
469
3026
2.16
27.72
2.6
2.0
88.2
94.9
pmol/l
2.75
293
1541
241
1186
2.42
27.59
4.7
3.3
0.8
0.8
mmol/l
0.01
232
1111
391
2357
2.18
27.45
5.6
3.2
34.1
33.0
u/l
0.19
379
2249
268
1388
2.33
27.26
4.8
4.0
104.4
351.6
ng/l
2.71
221
1090
60
136
4.66
24.89
6.1
6.1
1046.2
132.4
iu/ml
—
9
14
30
7
44.23
24.70
1.1
1.1
—
—
—
0
0
23
0
+∞
24.07
8.2
0.0
—
—
—
0
0
258
1377
2.23
23.98
2.0
1.7
1103.8
1173.1
nmol/l
0.50
199
1039
306
1755
2.13
23.65
2.0
1.5
20.8
20.8
nmol/l
0.00
286
1482
101
342
3.20
23.64
5.9
4.0
23.7
24.3
mmol/l
0.96
96
307
284
1583
2.17
23.62
2.5
1.6
1.5
1.1
mg/l
1.09
238
1220
694
5412
2.28
23.01
5.6
4.1
16.2
12.4
mm/h
5.47
653
4976
271
1501
2.16
22.77
3.3
2.6
3.9
5.2
e6/l
1.95
235
1322
55
128
4.51
22.07
1.3
1.2
—
—
—
0
0
(40770918) von Willebrand factor (vWf).activity actual/normal in Platelet poor plasma by Immunoassay
23
21
11.22
21.62
1.5
3.0
146.1
124.2
%
0.49
23
21
32
47
7.03
20.91
1.8
1.8
1051.7
759.0
e6/l
—
6
16
576
4275
1.98
20.50
8.8
4.8
6.7
6.7
mmol/l
0.07
554
4020
49
112
4.57
20.10
6.3
3.1
1.2
1.2
%
0.02
36
96
28
37
7.78
20.04
2.1
2.1
—
—
—
0
0
144
641
2.49
20.01
10.7
7.3
10.0
9.7
mmol/l
0.19
138
607
245
1371
2.09
19.62
3.6
3.0
2.5
2.4
mmol/l
0.34
218
1198
23
5
47.12
19.27
1.1
1.0
—
—
—
0
0
227
1248
2.10
18.97
3.4
2.8
0.8
1.2
e6/l
1.50
131
738
35
63
5.74
18.80
2.1
2.2
—
—
—
0
0
374
2480
1.88
17.95
4.1
3.3
2.3
2.4
mmol/l
1.15
337
2150
49
124
4.12
17.65
1.4
1.2
237.4
270.9
u/ml
0.31
34
71
27
40
6.93
17.49
2.0
2.2
680.0
540.7
e6/l
0.43
22
32
26
37
7.21
17.45
2.1
2.0
13.5
12.6
%
0.11
20
20
35
68
5.32
17.33
1.1
1.1
—
—
—
0
0
67
215
3.29
17.06
2.3
1.6
0.2
0.2
g/l
0.23
61
206
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
70
238
3.11
16.20
4.3
2.8
0.3
0.4
u/ml
0.30
41
130
719
5971
2.06
16.12
42.6
17.4
14.8
13.7
%
29.31
711
5852
50
138
3.78
15.99
1.6
1.3
—
—
—
0
0
50
138
3.78
15.99
1.6
1.3
—
—
—
0
0
67
224
3.15
15.95
2.3
1.6
1.2
1.2
g/l
0.78
62
213
117
526
2.41
15.76
2.2
1.5
—
—
—
0
0
158
817
2.14
15.21
2.2
1.8
—
—
—
0
0
332
2207
1.80
15.17
2.5
2.1
165.4
231.3
u/l
0.94
312
2088
481
3564
1.76
15.09
3.8
3.7
0.0
0.0
estimate
0.50
127
628
158
822
2.12
14.95
2.2
1.8
—
—
—
0
0
142
709
2.19
14.92
3.1
2.2
0.2
0.2
g/l
0.20
129
664
203
1165
1.96
14.63
2.3
1.8
—
—
—
0
0
474
3523
1.74
14.48
5.3
5.1
0.0
0.0
estimate
0.50
133
649
28
53
5.42
14.26
1.2
1.2
270.0
85.5
titre
—
6
11
471
3509
1.73
14.14
3.7
3.7
0.0
0.0
estimate
0.00
128
645
68
257
2.78
13.02
1.6
1.7
—
197.5
—
0
8
811
7226
2.38
12.62
30.1
14.2
21.6
24.0
mg/l
1.50
714
5733
143
773
2.01
12.06
4.3
3.2
—
—
—
0
0
17
8
21.63
12.04
1.1
1.3
—
—
—
0
0
22
39
5.76
11.99
1.6
1.1
—
—
—
0
0
36
98
3.79
11.76
1.4
1.2
1.4
2.5
u/ml
0.69
15
28
14
15
9.47
11.68
1.0
1.0
—
—
—
0
0
289
1969
1.69
11.42
1.8
1.7
1.5
1.4
mmol/l
1.88
226
1658
263
1757
1.71
11.14
5.5
2.3
—
—
—
0
0
402
2997
1.62
11.07
3.0
2.3
78.1
77.0
nmol/l
0.32
365
2665
36
103
3.60
10.96
1.4
1.2
4.9
6.0
u/ml
0.14
19
39
84
383
2.32
10.89
11.5
12.1
—
—
—
0
0
114
599
2.04
10.35
3.2
2.9
232.3
207.1
ng/l
0.26
104
551
124
677
1.97
10.10
5.9
3.7
1.0
2.0
mmol/l
1.56
101
545
124
687
1.94
9.66
5.9
3.6
5.9
5.8
kpa
0.31
117
668
111
594
1.99
9.56
5.3
3.7
1.2
1.2
mmol/l
0.05
90
516
119
661
1.92
9.19
2.4
2.0
330.1
378.4
nmol/l
2.11
113
605
25
63
4.05
9.10
1.2
1.2
—
—
—
0
0
36
925
0.36
8.73
7.9
7.3
—
—
—
0
0
31
94
3.38
8.68
1.2
1.1
—
—
—
0
0
19
40
4.83
8.62
2.6
1.2
11.4
5.9
ug/l
1.14
19
34
736
6540
1.72
8.59
38.8
15.3
39.2
39.8
%
0.87
536
4585
566
4726
1.54
8.58
4.7
3.1
59.9
49.1
u/l
1.53
543
4405
142
853
1.79
8.54
8.9
8.3
0.4
1.3
mmol/l
1.59
124
668
51
207
2.55
8.53
1.9
1.6
—
—
—
0
0
427
3390
1.50
8.00
7.8
4.0
—
—
—
0
0
84
443
1.99
7.53
2.1
1.7
—
—
—
0
0
736
6609
1.66
7.43
5.5
4.7
1.9
2.1
mu/l
0.47
679
6008
19
46
4.20
7.30
1.2
1.1
—
—
—
0
0
19
46
4.20
7.30
1.2
1.1
—
—
—
0
0
11
7
15.88
7.24
1.2
1.1
—
—
—
0
0
102
582
1.85
7.23
5.3
3.9
103.2
86.6
ng/l
0.88
91
512
310
2343
1.50
7.19
4.4
3.1
7.5
7.6
mmol/l
0.14
247
1962
309
2338
1.49
7.11
5.0
3.9
20.8
9.0
mg/mmol
1.82
195
1470
19
47
4.11
7.10
1.2
1.1
—
—
—
0
0
19
47
4.11
7.10
1.2
1.1
—
—
—
0
0
19
47
4.11
7.10
1.2
1.1
—
—
—
0
0
33
118
2.87
7.07
1.3
1.2
—
—
—
0
0
41
165
2.56
7.02
1.6
1.4
—
—
—
0
0
24
71
3.45
7.01
7.5
2.9
56.7
55.2
%
0.07
12
53
810
7498
1.89
6.98
31.4
16.5
139.3
139.7
mmol/l
4.06
796
7307
754
6842
1.67
6.95
30.0
13.1
79.5
79.8
ml/min/173m2
0.10
671
5615
811
7518
1.89
6.84
33.5
16.6
4.0
4.0
mmol/l
0.02
795
7311
18
44
4.15
6.84
1.9
1.6
3.1
11.4
u/l
1.15
13
25
63
313
2.09
6.65
2.1
2.1
37.1
38.2
u/l
0.17
54
278
741
6720
1.61
6.56
6.9
5.9
39.9
40.0
mmol/mol
0.08
689
6219
145
943
1.64
6.47
11.9
6.8
104.3
104.1
mmol/l
0.12
145
915
49
224
2.26
6.37
1.5
1.6
0.0
0.1
iu/ml
0.44
17
41
12
22
5.52
6.30
1.1
2.7
—
88552.6
—
0
5
287
2182
1.47
6.29
3.8
3.0
2311.1
1308.8
ng/l
1.85
235
1860
626
5509
1.46
6.08
4.5
3.9
14.8
14.8
pmol/l
0.20
557
4989
40
171
2.40
6.06
1.8
1.6
—
—
—
0
0
25
84
3.03
5.99
1.7
1.6
—
—
—
0
0
42
185
2.33
5.96
1.2
1.2
—
15.0
—
0
11
9
6
15.13
5.91
1.0
1.0
—
—
—
0
0
821
7694
1.87
5.90
21.6
10.4
27.0
26.3
u/l
0.66
797
7416
36
149
2.48
5.85
4.8
2.4
16.1
16.4
%
0.09
21
80
39
168
2.38
5.82
7.4
2.5
40.1
35.5
umol/l
0.46
34
140
39
169
2.37
5.75
1.8
1.6
—
—
—
0
0
25
90
2.83
5.34
1.4
1.2
0.7
0.6
nmol/l
0.31
25
85
9
9
10.09
5.03
1.1
1.0
103.2
112.4
%
—
9
9
291
2295
1.40
5.00
3.1
2.5
53.8
56.6
u/l
0.79
268
2135
49
249
2.02
4.93
1.6
1.4
21.2
27.5
iu/l
0.90
39
214
14
37
3.83
4.82
1.2
1.1
—
—
—
0
0
8
7
11.52
4.79
1.0
2.1
—
—
—
0
0
38
177
2.20
4.78
1.7
1.3
8.0
9.6
u/l
0.34
24
146
39
184
2.17
4.76
1.2
1.1
—
—
—
0
0
39
185
2.16
4.70
1.4
1.3
—
—
—
0
0
69
403
1.77
4.57
3.0
3.2
4.3
4.5
pmol/l
0.72
61
351
136
956
1.50
4.28
31.2
24.9
1.6
1.3
inr
—
9
124
13
36
3.65
4.21
1.1
1.1
—
—
—
0
0
21
79
2.70
4.18
2.5
4.1
—
—
—
0
0
43
224
1.97
4.08
2.4
1.7
—
—
—
0
0
23
92
2.54
4.07
1.3
1.3
—
—
—
0
0
46
247
1.91
4.00
2.3
3.0
—
—
—
0
0
18
65
2.81
3.87
1.2
1.0
—
—
—
0
0
202
1561
1.38
3.79
1.4
1.2
2.3
1.7
u/ml
0.18
41
423
200
1549
1.38
3.70
1.7
1.7
37908983.5
37470972.4
pmol/l
0.00
153
1273
38
197
1.97
3.68
4.1
2.6
24.6
24.7
mmol/l
0.02
38
173
87
580
1.55
3.51
4.2
2.9
4.6
4.5
kpa
0.13
80
561
12
36
3.37
3.48
1.2
1.3
—
—
—
0
0
11
32
3.47
3.34
1.2
1.0
—
—
—
0
0
61
944
0.62
3.27
4.8
4.5
29.1
32.1
%
1.65
47
627
14
49
2.89
3.20
1.7
1.4
11.1
14.2
u/l
0.90
14
44
23
104
2.24
3.18
1.6
1.5
—
—
—
0
0
39
216
1.84
3.14
1.5
1.2
—
—
—
0
0
32
166
1.96
3.13
3.2
2.2
136.1
131.9
g/l
0.30
23
124
21
92
2.31
3.12
1.3
1.3
985.1
1615.3
e6/l
0.84
16
62
6
8
7.54
3.06
1.2
1.0
—
—
—
0
0
321
2727
1.28
3.01
4.1
3.9
—
—
—
0
0
772
7325
1.41
3.00
6.0
5.0
2.6
2.7
mmol/l
5.83
731
6717
755
7140
1.38
2.97
5.4
4.4
1.3
1.5
mmol/l
24.60
717
6540
232
1894
1.30
2.95
4.3
4.0
0.0
0.0
estimate
0.69
123
631
731
6885
1.35
2.90
4.8
4.0
1.4
1.3
mmol/l
5.18
692
6269
66
433
1.57
2.89
1.5
1.2
204.6
237.4
u/ml
0.14
57
393
160
1243
1.35
2.87
1.3
1.3
40.3
33.3
iu/ml
0.15
49
392
19
84
2.29
2.78
1.4
1.3
228949.0
40853.3
e6/l
0.63
13
45
65
429
1.56
2.78
1.7
1.4
—
—
—
0
0
476
4267
1.25
2.74
3.2
2.8
—
—
—
0
0
28
146
1.95
2.73
1.4
1.2
—
—
—
0
0
16
66
2.45
2.72
1.3
1.8
—
—
—
0
0
747
7079
1.34
2.68
5.1
4.6
6.0
6.0
mmol/l
0.30
679
6437
75
518
1.49
2.62
3.4
2.2
12.7
13.1
nmol/l
0.15
70
458
38
222
1.74
2.61
1.6
2.2
—
—
—
0
0
17
74
2.32
2.59
1.0
1.1
—
—
—
0
0
25
128
1.98
2.57
1.9
1.7
—
—
—
0
0
6
11
5.48
2.54
4.2
6.0
—
—
—
0
0
38
224
1.73
2.54
1.4
1.5
264.9
289.6
ug/g
0.28
21
133
110
821
1.39
2.54
1.9
1.8
1.7
1.5
%
1.30
90
718
755
7184
1.34
2.49
5.6
4.5
4.3
4.6
mmol/l
13.81
723
6623
16
70
2.31
2.42
1.0
1.1
—
—
—
0
0
25
132
1.92
2.38
1.5
1.5
—
—
—
0
0
13
52
2.52
2.36
2.6
1.6
0.9
1.0
g/l
0.42
13
52
12
46
2.63
2.36
1.6
2.4
—
—
—
0
0
7
18
3.91
2.25
1.1
1.1
—
—
—
0
0
69
486
1.46
2.22
2.3
2.5
—
16.8
—
0
21
11
42
2.64
2.19
1.6
1.3
—
—
—
0
0
23
123
1.89
2.13
1.2
1.1
—
—
—
0
0
142
1133
1.30
2.12
1.6
1.5
—
—
—
0
0
9
31
2.92
2.07
1.0
1.1
—
—
—
0
0
5
10
5.02
2.07
1.0
1.1
—
—
—
0
0
82
605
1.39
2.06
3.3
2.7
59.3
65.7
ml/min/173m2
0.83
52
252
8
27
2.98
1.94
3.3
4.2
—
—
—
0
0
6
16
3.77
1.93
1.3
1.3
—
—
—
0
0
14
65
2.17
1.88
1.0
1.1
—
—
—
0
0
16
79
2.04
1.86
2.1
1.8
—
—
—
0
0
6
17
3.55
1.84
2.0
1.8
—
—
—
0
0
101
788
1.32
1.79
3.1
4.1
3.7
24.5
ug/l
1.28
83
649
8
29
2.77
1.79
1.1
1.2
—
—
—
0
0
825
8023
1.39
1.79
47.1
20.8
315.2
248.1
e9/l
27.82
808
7819
318
2824
1.20
1.78
4.5
3.6
35.9
50.4
ng/l
0.55
231
2006
143
1169
1.27
1.78
1.3
1.3
23.3
12.3
u/ml
0.52
39
443
825
8027
1.38
1.74
47.4
21.0
132.5
135.3
g/l
3.66
816
7902
64
470
1.39
1.69
4.1
3.5
2.1
1.9
mmol/l
0.22
47
347
19
104
1.84
1.68
1.4
1.5
—
—
—
0
0
8
31
2.59
1.66
1.1
1.6
1.2
8.3
nmol/l
—
8
22
28
173
1.64
1.65
4.6
2.8
8.1
8.1
kpa
0.01
28
157
35
230
1.54
1.62
1.2
1.2
—
—
—
0
0
5
14
3.59
1.61
1.2
1.2
—
—
—
0
0
5
14
3.59
1.61
2.0
1.4
—
—
—
0
0
10
43
2.34
1.60
1.1
1.0
—
—
—
0
0
19
106
1.81
1.59
1.0
1.1
—
—
—
0
0
6
21
2.87
1.50
1.0
1.0
1398.7
1531.3
miu/ml
—
6
21
8
167
0.47
1.48
2.0
3.8
33.0
25.6
mg/l
—
8
107
27
173
1.58
1.41
2.0
1.3
—
—
—
0
0
(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection
9
40
2.26
1.40
1.6
1.2
—
—
—
0
0
7
29
2.42
1.39
1.0
1.5
—
—
—
0
0
9
41
2.21
1.37
9.7
19.4
1045.9
1561.9
nmol/l
—
9
41
5
17
2.95
1.36
1.0
1.2
—
—
—
0
0
61
465
1.33
1.32
1.4
1.2
194.9
146.2
iu/ml
0.34
26
182
17
99
1.73
1.28
1.2
1.1
0.9
1.6
u/ml
—
10
36
6
25
2.41
1.24
1.8
1.1
—
—
—
0
0
33
229
1.46
1.23
1.2
1.2
—
—
—
0
0
41
297
1.40
1.22
3.5
3.3
832.8
4654.1
u/ml
0.57
36
256
13
71
1.84
1.20
2.3
1.8
—
—
—
0
0
8
38
2.12
1.18
1.0
1.1
—
—
—
0
0
5
20
2.51
1.15
1.2
1.3
—
—
—
0
0
11
58
1.91
1.12
2.2
2.2
712.0
614.3
ml
—
5
37
47
355
1.34
1.11
1.3
1.3
—
—
—
0
0
7
32
2.20
1.08
1.0
1.3
—
—
—
0
0
158
1379
1.18
1.07
2.8
3.0
0.6
0.8
ug/l
1.60
116
923
29
203
1.44
1.06
2.1
1.4
—
—
—
0
0
12
67
1.80
1.05
1.3
1.1
—
—
—
0
0
9
46
1.97
1.03
1.1
1.4
—
—
—
0
0
18
275
0.65
1.03
2.4
3.9
1.3
1.3
mmol/l
0.03
18
267
21
140
1.51
0.98
1.7
2.1
8863.0
3440.6
u/l
—
7
50
16
100
1.61
0.97
1.2
1.1
—
—
—
0
0
9
51
1.77
0.94
2.0
1.3
—
—
—
0
0
9
51
1.77
0.94
2.0
1.3
—
—
—
0
0
12
70
1.72
0.93
1.4
2.2
—
—
—
0
0
15
232
0.64
0.92
2.7
3.9
3.8
3.9
mmol/l
0.33
15
211
6
30
2.01
0.87
1.2
1.1
6.2
6.8
mmol/l
—
6
30
11
64
1.73
0.86
1.4
1.2
—
—
—
0
0
47
590
0.79
0.86
1.7
1.7
—
—
—
0
0
14
88
1.60
0.84
2.1
1.6
62.4
59.8
%
—
7
62
16
238
0.67
0.84
2.6
1.7
—
—
—
0
0
13
201
0.64
0.82
1.2
1.4
—
—
—
0
0
6
32
1.88
0.82
2.0
1.7
50.2
54.4
ug/l
—
6
32
5
25
2.01
0.72
1.0
1.1
108.2
180.6
iu/ml
—
5
25
144
1599
0.88
0.70
3.5
4.1
1.0
1.0
kg/l
0.01
31
214
26
195
1.34
0.70
3.4
2.4
282.9
104.5
ug/min
0.42
14
117
5
27
1.86
0.68
2.8
1.9
—
—
—
0
0
5
27
1.86
0.68
2.8
1.9
—
—
—
0
0
5
28
1.79
0.66
2.8
1.9
—
—
—
0
0
7
44
1.60
0.65
1.0
1.1
353.4
553.2
u/l
—
7
38
17
120
1.42
0.65
1.9
1.5
—
—
—
0
0
22
166
1.33
0.59
1.8
1.8
3.7
5.4
iu/l
—
8
51
8
53
1.51
0.58
1.5
1.2
—
70.4
—
0
7
9
62
1.46
0.53
1.9
1.5
—
—
—
0
0
7
49
1.43
0.46
1.4
1.4
—
33.3
—
0
6
15
112
1.35
0.45
1.7
1.6
—
—
—
0
0
10
69
1.45
0.44
1.5
1.2
—
—
—
0
0
5
31
1.62
0.43
1.0
1.0
—
—
—
0
0
0
16
0.00
0.41
0.0
1.0
—
25.4
—
0
16
0
16
0.00
0.41
0.0
1.1
—
1.1
—
0
6
0
18
0.00
0.40
0.0
6.2
—
73.2
—
0
13
7
101
0.69
0.39
1.3
1.4
—
—
—
0
0
7
101
0.69
0.39
1.3
1.4
—
—
—
0
0
7
101
0.69
0.39
1.1
1.4
—
—
—
0
0
7
101
0.69
0.39
1.1
1.4
—
—
—
0
0
61
542
1.13
0.39
2.4
1.9
—
—
—
0
0
7
105
0.66
0.39
1.3
1.6
—
—
—
0
0
5
35
1.43
0.39
2.8
1.7
—
—
—
0
0
5
35
1.43
0.39
2.8
1.7
—
—
—
0
0
5
35
1.43
0.39
2.8
1.7
—
—
—
0
0
5
35
1.43
0.39
2.8
1.7
—
—
—
0
0
9
67
1.35
0.38
1.3
1.1
1.2
1.5
nmol/l
—
9
62
15
117
1.29
0.35
1.6
1.5
—
—
—
0
0
22
182
1.21
0.33
1.3
1.2
—
—
—
0
0
6
88
0.68
0.33
1.5
1.6
—
—
—
0
0
109
1013
1.09
0.33
1.5
1.4
—
—
—
0
0
66
601
1.11
0.30
2.4
2.0
—
—
—
0
0
13
104
1.25
0.26
1.7
1.5
—
—
—
0
0
5
39
1.28
0.23
1.4
1.2
—
—
—
0
0
5
39
1.28
0.23
1.4
1.2
—
—
—
0
0
0
11
0.00
0.21
0.0
1.5
—
—
—
0
0
0
11
0.00
0.21
0.0
1.0
—
—
—
0
0
0
10
0.00
0.21
0.0
1.4
—
—
—
0
0
0
10
0.00
0.21
0.0
6.6
—
—
—
0
0
0
12
0.00
0.21
0.0
1.0
—
—
—
0
0
5
43
1.16
0.21
7.2
3.1
—
—
—
0
0
0
13
0.00
0.21
0.0
1.2
—
—
—
0
0
7
62
1.13
0.17
2.3
1.6
—
—
—
0
0
7
62
1.13
0.17
2.3
1.6
—
—
—
0
0
7
62
1.13
0.17
2.3
1.6
—
—
—
0
0
7
62
1.13
0.17
1.4
1.5
—
—
—
0
0
17
149
1.14
0.15
1.5
1.6
—
—
—
0
0
6
78
0.77
0.15
2.0
1.5
—
—
—
0
0
39
361
1.08
0.15
6.3
2.4
0.7
0.7
%
0.06
39
349
31
287
1.08
0.12
1.5
1.8
—
—
—
0
0
16
143
1.12
0.11
1.7
3.6
484.8
314.4
u/ml
0.13
16
138
5
44
1.14
0.10
1.0
1.8
15.8
20.3
nmol/l
—
5
38
37
351
1.06
0.08
1.0
1.0
—
—
—
0
0
5
60
0.83
0.08
1.4
1.4
—
—
—
0
0
6
71
0.84
0.07
1.3
1.6
—
—
—
0
0
19
176
1.08
0.07
1.4
1.5
—
—
—
0
0
242
2391
1.02
0.06
4.2
5.0
2.1
2.5
ug/l
0.53
215
2134
28
292
0.96
0.04
2.8
1.8
—
—
—
0
0
26
271
0.96
0.04
2.5
1.7
—
—
—
0
0
10
109
0.92
0.04
2.1
1.3
—
—
—
0
0
10
109
0.92
0.04
2.1
1.3
—
—
—
0
0
10
108
0.93
0.03
2.1
1.3
—
—
—
0
0
63
641
0.98
0.02
2.2
2.4
7.5
6.8
ug/l
0.15
56
561
21
202
1.04
0.02
1.2
1.3
—
—
—
0
0
10
107
0.93
0.02
2.1
1.3
—
—
—
0
0
10
107
0.93
0.02
2.1
1.3
—
—
—
0
0
10
107
0.93
0.02
2.1
1.3
—
—
—
0
0
40
408
0.98
0.01
3.2
2.7
0.1
0.2
e6/l
0.39
40
394
18
178
1.01
0.00
1.2
1.3
233.2
241.4
miu/ml
0.04
11
87
192
1922
1.00
0.00
3.5
4.3
24.5
21.3
%
1.57
82
923
22
221
1.00
0.00
1.5
1.7
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
65.2
—
0
5
0
7
0.00
0.00
0.0
1.4
—
—
—
0
0
9
90
1.00
0.00
1.2
1.2
7.5
7.3
mmol/l
—
9
59
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
2.5
—
—
—
0
0
0
9
0.00
0.00
0.0
1.1
—
—
—
0
0
0
7
0.00
0.00
0.0
2.6
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
5
54
0.93
0.00
1.8
1.4
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint D3_BLOODNAS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| D3_BLOODNAS | 2.238 [1.91, 2.63] | < 0.001 |
| Birth year | 0.995 [0.99, 1.0] | 0.245 |
During the follow-up period (1.1.1998 — 31.12.2019), 570 out of 2131 females with D3_BLOODNAS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| D3_BLOODNAS | 2.256 [1.9, 2.67] | < 0.001 |
| Birth year | 0.981 [0.97, 0.99] | < 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 665 out of 1883 males with D3_BLOODNAS died.
Mortality risk
Mortality risk for people of age
years, who have D3_BLOODNAS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.227% | 0.362% |
| 5 | 1.374% | 2.281% |
| 10 | 3.61% | 5.483% |
| 15 | 6.907% | 9.997% |
| 20 | 11.592% | 16.14% |
Relationships between endpoints
↥Index endpoint: D3_BLOODNAS – Other and unspecified diseases of blood and blood-forming organs
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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