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Injury of nerves at lower leg level

ST19_INJURY_NERVES_LOWER_LEG_LEVEL

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 S84
  • Cause of death: ICD-10 S84

2 out of 7 registries used, show all original rules.

360

4. Check minimum number of events

None

360

5. Include endpoints

None

360

6. Filter based on genotype QC (FinnGen only)

360

Control definitions (FinnGen only)

Control exclude
ST19_INJURI_KNEE_LOWER_LEG

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF4
Parent code in ICD-10
S8
Name in latin
Laesio nervorum in regione genus/cruris

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

-FinnGen-

Key figures

All Female Male
Number of individuals 360 187 173
Unadjusted period prevalence (%) 0.07 0.06 0.08
Median age at first event (years) 50.70 49.02 52.52

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
322
Matched controls
3218
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
S84.1
ICD-10 Finland
Injury of peroneal nerve at lower leg level
2298.4
224.0
191
*
X59
ICD-10 Finland
Exposure to unspecified factor
10.6
65.0
146
233
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
8.1
59.4
168
381
G57.3
ICD-10 Finland
Lesion of lateral popliteal nerve
70.8
55.9
63
11
S84.2
ICD-10 Finland
Injury of cutaneous sensory nerve at lower leg level
+∞
51.5
48
*
S84.0
ICD-10 Finland
Injury of tibial nerve at lower leg level
+∞
47.0
44
*
X58
ICD-10 Finland
Exposure to other specified factors
7.3
36.1
96
176
S83.2
ICD-10 Finland
Tear of meniscus, current
85.6
28.3
31
*
S84.9
ICD-10 Finland
Injury of unspecified nerve at lower leg level
+∞
27.5
26
*
NG4AA
NOMESCO Finland
Lower leg X-ray examination
44.1
26.4
32
8
NHJ10
NOMESCO Finland
Internal fixation of fracture of ankle using wire, rod, cerclage or pin
282.0
26.1
26
*
R4110
NOMESCO Finland
Physiotherapy
4.0
25.8
131
472
ZXD05
NOMESCO Finland
Urgent procedure
3.6
24.0
144
588
N03AX16
ATC
pregabalin; oral
3.9
23.5
121
434
NG1AA
NOMESCO Finland
Knee X-ray examination without contrast
6.1
23.2
68
136
N02AX02
ATC
tramadol; systemic, rectal
3.3
23.1
175
847
NH1AA
NOMESCO Finland
Ankle X-ray examination without contrast
10.2
21.4
43
48
N03AX12
ATC
gabapentin; oral
4.5
21.0
84
236
S82.8
ICD-10 Finland
Fractures of other parts of lower leg
223.9
20.8
21
*
B01AB05
ATC
enoxaparin; parenteral
3.3
20.1
129
537
Z3226
NOMESCO Finland
Physiotherapist
3.9
20.1
95
310
ZXE10
NOMESCO Finland
More than one and less than three hours
3.0
18.8
146
689
NGU20
NOMESCO Finland
Removal of internal fixation device from knee or lower leg
47.0
18.5
22
5
ZXA05
NOMESCO Finland
Left side
3.4
18.4
108
414
S82.3
ICD-10 Finland
Fracture of lower end of tibia
+∞
17.9
17
*
W19
ICD-10 Finland
Unspecified fall
6.2
17.9
50
93
TNG34
NOMESCO Finland
Major custom moulded orthopaedic cast, knee or lower leg
53.1
17.2
20
*
QDB10
NOMESCO Finland
Major dressing of wound of skin of lower limb
9.4
17.0
35
41
TNX33
NOMESCO Finland
Custom moulded cast, unspecified region
10.4
16.9
33
35
S83.5
ICD-10 Finland
Sprain and strain involving (anterior)(posterior) cruciate ligament of knee
178.9
16.7
17
*
N03AX09
ATC
lamotrigine; oral
7.6
16.5
39
57
Y83
ICD-10 Finland
Surgical operation and other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
5.9
16.4
47
90
N05AH04
ATC
quetiapine; oral
3.5
16.0
85
298
S83.6
ICD-10 Finland
Sprain and strain of other and unspecified parts of knee
16.8
16.0
25
16
QDB05
NOMESCO Finland
Revision of wound of skin of lower limb
16.8
16.0
25
16
S84.8
ICD-10 Finland
Injury of other nerves at lower leg level
+∞
15.8
15
*
Z3231
NOMESCO Finland
Registered nurse
3.0
15.7
115
507
N02BE01
ATC
paracetamol; systemic, rectal
3.8
15.3
290
2268
TNX99
NOMESCO Finland
Other orthopaedic minor procedure
12.2
15.1
27
24
S82.2
ICD-10 Finland
Fracture of shaft of tibia
+∞
14.7
14
*
T93.4
ICD-10 Finland
Sequelae of injury of nerve of lower limb
+∞
14.7
14
*
ZXM10
NOMESCO Finland
Intraoperative use of conventional X-ray imaging
6.6
14.3
37
62
ZXD10
NOMESCO Finland
Scheduled procedure
2.6
13.9
148
804
ZXA00
NOMESCO Finland
Right side
2.9
13.8
103
452
S80.0
ICD-10 Finland
Contusion of knee
6.9
13.6
34
54
NGJ62
NOMESCO Finland
Internal fixation of fracture of knee or lower leg using plate and screws, other or unspecified
+∞
13.6
13
*
WX320
NOMESCO Finland
Spinalanesthesy
3.0
13.5
88
354
W00
ICD-10 Finland
Fall on same level involving ice and snow
4.5
13.4
49
123
T93.2
ICD-10 Finland
Sequelae of other fractures of lower limb
52.2
13.0
15
*
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
2.4
12.7
168
1006
NGJ70
NOMESCO Finland
External fixation of fracture of knee or lower leg, other or unspecified
+∞
12.6
12
*
S82.1
ICD-10 Finland
Fracture of upper end of tibia
135.1
12.5
13
*
M79.6
ICD-10 Finland
Pain in limb
2.5
12.5
132
704
NGF25
NOMESCO Finland
Operation for osteochondritis of knee, arthroscopic
5.9
12.2
34
63
NH1AD
NOMESCO Finland
Ankle and foot CT
14.1
12.1
20
15
S93.4
ICD-10 Finland
Sprain and strain of ankle
3.9
12.0
52
153
M89.0
ICD-10 Finland
Algoneurodystrophy
48.6
12.0
14
*
N06AX21
ATC
duloxetine; oral
3.6
12.0
56
176
S82.6
ICD-10 Finland
Fracture of lateral malleolus
15.8
11.4
18
12
ZXE00
NOMESCO Finland
One hour or less
2.3
11.4
142
814
NG1BG
NOMESCO Finland
Knee and lower leg MRI examination with high intensity magnet
8.1
11.4
25
33
R4120
NOMESCO Finland
Occupational therapy
4.8
11.4
38
87
XF400
NOMESCO Finland
ECG with 12 standard connections
3.2
11.4
63
225
S82.4
ICD-10 Finland
Fracture of fibula alone
36.5
11.4
14
*
TNX50
NOMESCO Finland
Removal of cutom molded cast and internal stretch
7.9
11.2
25
34
W10
ICD-10 Finland
Fall on and from stairs and steps
6.1
10.9
29
51
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
3.1
10.8
65
245
NGA30
NOMESCO Finland
Exploration of knee joint, arthroscopic
7.0
10.7
26
40
Y88.3
ICD-10 Finland
Sequelae of surgical and medical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
8.7
10.5
22
27
S83.4
ICD-10 Finland
Sprain and strain involving (fibular)(tibial) collateral ligament of knee
12.6
10.5
18
15
NGU10
NOMESCO Finland
Removal of external fixation device from knee or lower leg
+∞
10.5
10
*
TPH04
NOMESCO Finland
Cathetrisation of vein
2.6
10.4
85
386
NGD05
NOMESCO Finland
Partial excision of meniscus of knee, arthroscopic
4.1
10.3
40
107
N06AX11
ATC
mirtazapine; oral
2.3
10.2
117
636
L28
ICPC
Limited function/disability (L)
3.1
10.1
60
222
N02AJ06
ATC
codeine and paracetamol; systemic
2.2
10.0
132
764
L15
ICPC
Knee symptom/complaint
2.7
9.9
75
326
A02BC02
ATC
pantoprazole; systemic
2.2
9.9
211
1504
NG1AD
NOMESCO Finland
Knee CT examination
20.8
9.9
14
7
ZXE20
NOMESCO Finland
More than three and less than five hours
3.1
9.8
58
214
S81.8
ICD-10 Finland
Open wound of other parts of lower leg
14.0
9.8
16
12
S86.0
ICD-10 Finland
Injury of Achilles tendon
56.7
9.7
11
*
T81.4
ICD-10 Finland
Infection following a procedure, not elsewhere classified
3.3
9.6
49
164
N06AX16
ATC
venlafaxine; oral
2.8
9.6
65
263
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
3.5
9.5
46
148
NGE35
NOMESCO Finland
Plastic repair of ligament of knee not using prosthetic material, anterior cruciate, arthroscopic
102.9
9.5
10
*
TNH32
NOMESCO Finland
Custom moulded split, ankle or foot
102.9
9.5
10
*
S89.9
ICD-10 Finland
Unspecified injury of lower leg
9.1
9.4
19
22
A28
ICPC
Limited function/disability NOS
3.3
9.4
49
167
S82.7
ICD-10 Finland
Multiple fractures of lower leg
+∞
9.4
9
*
S83.1
ICD-10 Finland
Dislocation of knee
+∞
9.4
9
*
TQW40
NOMESCO Finland
Remowal of suture of skin
4.6
9.3
32
76
F32.9
ICD-10 Finland
Depressive episode, unspecified
3.1
9.3
54
199
W17
ICD-10 Finland
Other fall from one level to another
5.9
9.3
25
45
NHU20
NOMESCO Finland
Removal of internal fixation device from ankle or foot
7.8
9.1
20
27
S83.0
ICD-10 Finland
Dislocation of patella
37.8
9.1
11
*
L16
ICPC
Ankle symptom/complaint
3.3
9.1
46
154
R52.1
ICD-10 Finland
Chronic intractable pain
19.3
9.0
13
7
X69
ICD-10 Finland
Intentional self-poisoning by and exposure to other and unspecified chemicals and noxious substances
5.5
9.0
26
51
Z01.8
ICD-10 Finland
Other specified special examinations
2.4
8.9
86
426
ZZA00
NOMESCO Finland
Split skin graft
11.2
8.9
16
15
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.1
8.9
137
840
N05BA04
ATC
oxazepam; oral
2.3
8.8
91
463
V49.9
ICD-10 Finland
Car occupant [any] injured in unspecified traffic accident
6.1
8.8
23
40
S06.0
ICD-10 Finland
Concussion
3.4
8.7
43
141
F10.1
ICD-10 Finland
Mental and behavioural disorders due to use of alcohol, Harmful use
4.0
8.7
34
92
NF3AA
NOMESCO Finland
Femur X-ray examination
10.5
8.6
16
16
WX408
NOMESCO Finland
General anesthesy, balanced
2.3
8.6
97
517
N05CF01
ATC
zopiclone; oral
2.2
8.5
104
575
S18
ICPC
Laceration/cut
2.1
8.5
137
852
NHL10
NOMESCO Finland
Suture or reinsertion of achilles tendon
92.4
8.5
9
*
S83.7
ICD-10 Finland
Injury to multiple structures of knee
92.4
8.5
9
*
A01
ICPC
Pain general/multiple sites
3.7
8.4
36
105
AA1AD
NOMESCO Finland
CT of head and brain
2.4
8.4
78
374
X57
ICD-10 Finland
Unspecified privation
8.9
8.4
17
20
G56.4
ICD-10 Finland
Causalgia
+∞
8.4
8
*
TNX34
NOMESCO Finland
Major custom molded cast, unspecified region
15.0
8.3
13
9
M01AE01
ATC
ibuprofen; systemic, rectal
2.9
8.3
296
2558
NA1AD
NOMESCO Finland
Cervical spine CT examination
5.8
8.1
22
40
T36
ICD-10 Finland
Poisoning by systemic antibiotics
4.4
8.0
28
68
Y94.8
ICD-10 Finland
Other leisure activity accident
7.3
7.9
18
26
M17.1
ICD-10 Finland
Other primary gonarthrosis
2.5
7.9
66
301
R52.2
ICD-10 Finland
Other chronic pain
5.5
7.8
22
42
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
3.2
7.8
40
135
M23.9
ICD-10 Finland
Internal derangement of knee, unspecified
3.5
7.8
35
107
ABD30
NOMESCO Finland
Implantation of spinal stimulation device
15.5
7.8
12
8
M25.5
ICD-10 Finland
Pain in joint
2.1
7.8
102
575
QCB10
NOMESCO Finland
Major dressing of wound of skin of upper limb
9.2
7.6
15
17
TNX92
NOMESCO Finland
Supporting bandage or orthosis of lower limb
13.8
7.4
12
9
F10.21
ICD-10 Finland
Alcohol dependence currently abstinent, but staying in restrictive environment
13.8
7.4
12
9
N02AA05
ATC
oxycodone; systemic
2.7
7.4
51
209
WX002
NOMESCO Finland
Sedation and analgesia
2.4
7.4
68
325
NH1BA
NOMESCO Finland
Ankle extensive X-ray examination
8.7
7.4
15
18
Z2446
NOMESCO Finland
Social worker
3.5
7.3
33
101
S84.7
ICD-10 Finland
Injury of multiple nerves at lower leg level
+∞
7.3
7
*
TNH33
NOMESCO Finland
Custom moulded brace, ankle or foot
16.2
7.3
11
7
XPX99
NOMESCO Finland
Other diagnostic examination of periferal vessel
3.9
7.2
28
76
Z50.1
ICD-10 Finland
Other physical therapy
4.2
7.2
26
66
J01FF01
ATC
clindamycin; systemic
2.1
7.1
96
546
M54.9
ICD-10 Finland
Dorsalgia, unspecified
2.8
7.0
44
170
M01AH05
ATC
etoricoxib; oral
1.9
6.9
186
1361
P15
ICPC
Chronic alcohol abuse
6.3
6.9
17
28
ZXE05
NOMESCO Finland
Procedure duration 40 to 49 minutes
3.6
6.8
29
85
NA3BG
NOMESCO Finland
Lumbar spine MRI examination with high intensity magnet
3.0
6.8
39
142
WX213
NOMESCO Finland
Lower leg blockade
17.1
6.8
10
6
T79.6
ICD-10 Finland
Traumatic ischaemia of muscle
40.9
6.8
8
*
WX872
NOMESCO Finland
Intensive care
4.2
6.8
24
60
Z09.4
ICD-10 Finland
Follow-up examination after treatment of fracture
5.0
6.7
20
42
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
2.5
6.6
52
230
L17
ICPC
Foot/toe symptom/complaint
2.1
6.5
82
451
M17.3
ICD-10 Finland
Other post-traumatic gonarthrosis
7.6
6.5
14
19
S82.0
ICD-10 Finland
Fracture of patella
71.2
6.4
7
*
Z2221
NOMESCO Finland
Medical doctor
2.0
6.4
93
539
M17.0
ICD-10 Finland
Primary gonarthrosis, bilateral
2.7
6.4
42
168
NG1CG
NOMESCO Finland
Knee and lower leg extensive MRI examination with high intensity magnet
8.4
6.4
13
16
M01AB05
ATC
diclofenac; systemic, rectal
1.8
6.4
216
1689
J01MA02
ATC
ciprofloxacin; systemic
1.9
6.4
118
754
TQW11
NOMESCO Finland
Vacuum treatment of wound
9.5
6.3
12
13
M84.1
ICD-10 Finland
Nonunion of fracture [pseudarthrosis]
18.5
6.3
9
5
ABD32
NOMESCO Finland
Implantation of temporary spinal stimulation device
18.5
6.3
9
5
NGE55
NOMESCO Finland
Plastic repair or reinsertion of cruciate and collateral ligaments of the knee, arthroscopic
+∞
6.3
6
*
NGJ60
NOMESCO Finland
Internal fixation of fracture of knee or lower leg using intramedullary nail, other or unspecified
+∞
6.3
6
*
N06AA10
ATC
nortriptyline; systemic
6.5
6.2
15
24
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.9
6.2
114
722
ACC59
NOMESCO Finland
Decompression and freeing of adhesions of peripheral nerve: other or unspecified
4.0
6.1
23
61
NGM10
NOMESCO Finland
Fasciotomy of of knee or lower leg
12.8
6.1
10
8
TNX32
NOMESCO Finland
Custom moulded splint, unspecified region
4.7
6.1
19
42
R51.80
ICD-10 Finland
Headache
2.4
6.1
55
259
ZXD35
NOMESCO Finland
Usual procedure
5.7
6.1
16
29
NA2AA
NOMESCO Finland
Thoracal spine X-ray examination without contrast
6.2
6.1
15
25
F33.2
ICD-10 Finland
Recurrent depressive disorder, current episode severe without psychotic symptoms
3.7
6.1
25
72
ZXE06
NOMESCO Finland
Procedure duration 50 to 59 minutes
3.5
6.1
27
83
N05AH03
ATC
olanzapine; systemic
3.1
6.0
31
106

Mortality – FinRegistry

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

Relationships between endpoints

Index endpoint: ST19_INJURY_NERVES_LOWER_LEG_LEVEL – Injury of nerves at lower leg level

GWS hits: -

This endpoint is excluded from FinRegistry analyses (omitted endpoint).