Benign neoplasm: Prostate

CD2_BENIGN_PROSTATE

No definition available.

Endpoint definition

↥

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule only males	226837
2. Check conditions None	226837
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — D29.1& Hospital discharge: ICD-9 — 2222 Cause of death: ICD-10 — D29.1& Cause of death: ICD-9 — 2222 2 out of 7 registries used, show all original rules.	225
4. Check minimum number of events None	225
5. Include endpoints None	225
6. Filter based on genotype QC (FinnGen only)	225

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy: 3
First used in FinnGen datafreeze: DF2
Parent code in ICD-10: D29
Name in latin: Neoplasma benignum prostatae

NAME	CD2_BENIGN_PROSTATE
CONTROL_EXCLUDE
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX	1
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	D291
HD_ICD_9	2222
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	D291
COD_ICD_9	2222
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Benign neoplasm: Prostate based on the number of shared cases.

Similar with more cases:

Similar with less cases:

Benign neoplasm: Prostate

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	1360	-	1360
Only index persons	1120	-	1120
Unadjusted period prevalence (%)
Whole population	0.04	-	0.04
Only index persons	0.04	-	0.04
Median age at first event (years)
Whole population	-	-	71.01
Only index persons	-	-	69.61

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	225	-	225
Unadjusted period prevalence (%)	0.10	-	0.10
Median age at first event (years)	67.88	-	67.88

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
206: Matched controls
2060

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

D29.1

ICD-10 Finland

Benign neoplasm: Prostate

16384.0

281.1

203

C61

ICD-10 Finland

Malignant neoplasm of prostate

5.9

28.5

103

299

8140/3-C61.9

ICD-O-3

Adenocarcinoma, NOS, of prostate gland

5.5

26.2

290

JN3CD

NOMESCO Finland

Abdominal CT examination both without and with contrast

11.2

21.6

NK6AN

NOMESCO Finland

Total body bone isotope imaging

10.9

18.6

KEC01

NOMESCO Finland

Percutaneous endoscopic radical prostatectomy

10.9

18.0

ZXC96

NOMESCO Finland

Robot assisted procedure

10.9

16.6

116

Kela drug reimbursment

Prostate cancer

4.1

12.9

167

Z03.89

ICD-10 Finland

Observation for other suspected diseases and conditions

4.1

10.5

124

KE1BE

NOMESCO Finland

Rectal ultrasound examinaiton of prostata

3.2

10.2

244

KE1AT

NOMESCO Finland

Biopsy of prostata with ultrasoudnguidance

3.8

9.8

132

UKC02

NOMESCO Finland

Cystoscopy

2.7

9.5

396

N40

ICD-10 Finland

Hyperplasia of prostate

2.5

9.4

125

781

Y77

ICPC

Malignant neoplasm prostate

4.9

8.9

XJH00

NOMESCO Finland

Transanal ultrasonography

2.9

7.1

185

XKD00

NOMESCO Finland

Uroflowmetry

2.3

6.9

484

PJD64

NOMESCO Finland

Laparoscopic dissection of iliac lymph nodes

8.2

6.7

Z03.8

ICD-10 Finland

Observation for other suspected diseases and conditions

4.9

6.5

R31

ICD-10 Finland

Unspecified haematuria

2.6

6.4

219

GD1AA

NOMESCO Finland

Thorax X-ray examination

2.1

6.3

117

794

LabWAS

↥

(ID) Name

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(42868674) Cholesterol in HDL/Cholesterol.total [Molar ratio] in Serum or Plasma

256

4.30

22.79

5.7

4.8

32.8

31.4

0.41

168

(3019225) pH of Specimen

199

3.58

14.29

6.9

4.0

—

(3044254) Respiratory syncytial virus RNA [Presence] in Specimen by NAA with probe detection

3.97

9.76

1.7

1.8

—

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

240

2.71

8.63

9.8

9.0

—

(46235759) Influenza virus B RNA [Presence] in Nasopharynx by NAA with probe detection

3.57

8.42

1.8

2.0

—

(3004490) Bicarbonate [Moles/volume] standard in Capillary blood

103

3.33

7.82

5.7

5.0

23.6

25.3

mmol/l

2.05

(3013512) EKG study

101

616

2.16

7.28

5.7

4.7

—

(3013603) Prostate specific Ag [Mass/volume] in Serum or Plasma

181

1445

2.29

5.83

8.4

5.5

2.9

ug/l

0.00

151

1266

(3007220) Creatine kinase [Enzymatic activity/volume] in Serum or Plasma

577

1.93

5.27

3.0

2.1

460.3

397.1

u/l

0.10

538

(3037467) Urinalysis macro (dipstick) panel - Urine

155

1190

1.97

5.22

5.9

4.2

—

(3023601) Vancomycin resistant enterococcus [Presence] in Specimen by Organism specific culture

4.98

5.07

2.9

2.7

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

371

2.01

4.97

1.7

1.8

—

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

146

2.48

4.93

1.4

1.6

—

(3022313) Gas panel - Capillary blood

127

2.57

4.90

5.2

4.2

—

(40761535) Cells panel - Urine sediment

163

2.36

4.68

4.1

3.6

—

(3023024) Carbon dioxide [Partial pressure] in Capillary blood

170

2.33

4.66

5.3

4.0

4.8

5.1

kpa

1.45

160

(3017732) Neutrophils [#/volume] in Blood

119

2.55

4.54

2.3

3.2

3.8

4.1

e9/l

0.27

(3045414) Leukocytes [Presence] in Urine

3.17

4.51

1.8

1.6

—

(43055554) Base excess.100% oxygenated [Moles/volume] standard in Capillary blood by calculation

159

2.34

4.50

5.5

4.2

0.3

2.0

mmol/l

1.49

122

(3046279) Procalcitonin [Mass/volume] in Serum or Plasma

107

2.62

4.49

1.8

2.2

1.2

2.4

ug/l

0.50

(3044889) 12 lead EKG panel

1215

0.56

4.32

3.9

4.6

—

(4146454)

4.23

4.21

2.5

2.9

—

(3026910) Gamma glutamyl transferase [Enzymatic activity/volume] in Serum or Plasma

128

972

1.74

3.96

3.6

3.2

58.9

62.9

u/l

0.22

114

891

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

466

1.80

3.89

2.6

2.5

—

(3032080) INR in Blood by Coagulation assay

120

907

1.69

3.68

7.2

11.3

1.2

1.4

inr

0.91

242

(3007778) Kappa light chains/Lambda light chains [Mass Ratio] in Serum

2.67

3.57

2.4

3.1

—

1.5

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

722

1.66

3.40

2.2

2.1

—

(1761868) Lipid panel - Serum or Plasma

468

0.48

3.14

2.5

3.3

—

(3021589) Normoblasts [#/volume] in Blood

754

0.57

3.13

9.1

10.5

0.0

e9/l

0.59

618

(3049717) Cytology report of Urine Cyto stain

128

2.17

3.06

2.6

3.4

—

(3023465) Gamma globulin [Mass/volume] in Serum or Plasma by Electrophoresis

2.52

3.05

2.6

3.1

10.6

10.8

g/l

0.03

(3044640) Blood type and Crossmatch panel - Blood

620

1.63

3.02

2.7

2.6

—

(3014051) Protein [Presence] in Urine by Test strip

3.44

2.94

2.3

2.0

—

(3004588) Protein electrophoresis panel - Serum or Plasma

152

2.04

2.91

4.0

2.7

—

(40771025) 25-Hydroxyvitamin D3+25-Hydroxyvitamin D2 [Moles/volume] in Serum or Plasma

592

1.61

2.83

2.2

2.0

76.4

75.9

nmol/l

0.05

506

(3003338) MCHC [Mass/volume]

1241

0.64

2.76

26.3

25.2

332.7

332.8

g/l

0.04

1230

(3043747) Beta 2 globulin [Mass/volume] in Serum or Plasma by Electrophoresis

2.29

2.66

2.5

2.9

3.8

3.7

g/l

—

(3043723) Beta 1 globulin [Mass/volume] in Serum or Plasma by Electrophoresis

2.29

2.66

2.5

2.9

—

(3005229) Alpha 2 globulin [Mass/volume] in Serum or Plasma by Electrophoresis

2.29

2.66

2.5

2.9

7.0

7.1

g/l

0.10

(3017704) Immunofixation for Urine

5.57

2.56

2.3

1.4

—

(3004383) Neutrophil cytoplasmic Ab.classic [Titer] in Serum by Immunofluorescence

2.91

2.51

1.5

1.2

—

(3025468) Yersinia sp identified in Specimen by Organism specific culture

3.56

2.51

1.7

—

(3024522) Salmonella sp identified in Specimen by Organism specific culture

3.56

2.51

1.7

—

(3012568) Campylobacter sp identified in Specimen by Organism specific culture

3.56

2.51

1.7

—

(40768804) Tissue Pathology biopsy report

655

1.54

2.44

2.4

2.3

—

(21493466) Plesiomonas shigelloides DNA [Presence] in Stool by NAA with non-probe detection

3.43

2.42

1.7

—

(3005988) Vibrio sp identified in Specimen by Organism specific culture

3.43

2.42

1.7

—

(4010399)

127

2.00

2.37

1.9

1.5

—

(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma

115

925

1.50

2.33

9.5

7.4

1.2

mmol/l

0.37

784

(3021347) Calcium.ionized [Moles/volume] in Serum or Plasma

108

858

1.50

2.32

7.5

6.5

1.2

mmol/l

0.07

763

(37021247) Adenovirus 40+41 DNA [Presence] in Stool by NAA with probe detection

4.71

2.28

1.3

1.4

—

(37020445) Astrovirus RNA [Presence] in Stool by NAA with probe detection

4.71

2.28

1.3

1.4

—

(40761536) Microorganisms panel - Urine sediment

151

0.32

2.24

9.4

3.6

—

(40760888) Immunoglobulin light chains.free panel - Serum

2.58

2.22

3.2

—

(3029187) Natriuretic peptide.B prohormone N-Terminal [Mass/volume] in Serum or Plasma

732

1.49

2.20

3.3

1747.0

1683.0

ng/l

0.07

643

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

104

828

1.48

2.17

4.6

4.5

35.2

47.9

ng/l

0.79

667

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

103

820

1.47

2.14

2.2

2.1

101.6

89.2

pmol/l

1.10

487

(3029713) Protein.monoclonal band 1 [Mass/volume] in Serum or Plasma by Electrophoresis

2.22

2.14

1.3

3.2

1.3

0.5

g/l

0.45

(3015322) Alpha 1 globulin [Mass/volume] in Serum or Plasma by Electrophoresis

2.16

2.13

1.2

3.0

2.8

3.1

g/l

—

(3023368) Bacteria identified in Blood by Culture

681

1.48

2.10

4.0

4.5

—

(42869457) Rotavirus RNA [Identifier] in Stool by NAA with probe detection

4.08

2.05

1.3

—

(37020957) Sapovirus genogroups I+II+IV+V RNA [Presence] in Stool by NAA with probe detection

4.08

2.05

1.3

—

(3025941) Bacteria identified in Stool by Culture

2.22

2.03

1.1

1.3

—

(42870588) Differential panel, method unspecified - Blood

604

1.47

1.99

5.3

5.5

—

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

182

1639

1.58

1.94

21.1

18.8

27.3

29.6

mg/l

0.42

155

1394

(3023520) Reticulocytes [#/volume] in Blood

215

1.68

1.94

2.2

69.1

65.7

e9/l

0.31

172

(3035995) Alkaline phosphatase [Enzymatic activity/volume] in Serum or Plasma

157

1373

1.47

1.91

8.2

77.7

82.8

u/l

0.78

147

1286

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

104

843

1.43

1.91

4.0

4.4

—

(3013707) Erythrocyte sedimentation rate by Westergren method

144

1245

1.44

1.82

5.2

4.1

15.6

14.0

mm/h

0.43

126

1131

(3019069) Monocytes/100 leukocytes in Blood

792

1.42

1.81

5.4

5.9

8.8

9.2

0.46

734

(3037756) Immunofixation for Serum or Plasma

2.41

1.80

2.5

1.3

—

(3002030) Lymphocytes/100 leukocytes in Blood

804

1.41

1.77

5.3

5.9

23.8

24.6

0.25

741

(3009201) Thyrotropin [Units/volume] in Serum or Plasma

161

1425

1.46

1.76

4.4

3.8

2.0

2.1

mu/l

0.33

125

1224

(3001122) Ferritin [Mass/volume] in Serum or Plasma

673

1.42

1.74

2.8

2.7

210.2

192.1

ug/l

0.21

610

(3008757) Leukocyte morphology finding [Identifier] in Blood

2.73

1.74

3.0

5.4

—

(42868716) Shigella species+EIEC invasion plasmid antigen H ipaH gene [Presence] in Stool by NAA with probe detection

2.98

1.73

1.9

1.8

—

(3006504) Eosinophils/100 leukocytes in Blood

789

1.40

1.70

5.1

5.6

2.7

2.9

0.56

730

(3019832) Treponema pallidum Ab [Presence] in Serum

2.45

1.70

1.5

1.3

—

(3019550) Sodium [Moles/volume] in Serum or Plasma

190

1744

1.58

1.69

25.6

22.5

139.5

139.6

mmol/l

0.26

178

1696

(3028286) Albumin [Mass/volume] in Serum or Plasma by Electrophoresis

2.10

1.68

1.2

3.2

35.9

37.1

g/l

—

(3020630) Protein [Mass/volume] in Serum or Plasma

183

1.67

3.9

3.0

64.3

66.0

g/l

0.56

159

(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)

172

1550

1.47

1.64

19.2

17.6

68.7

72.4

ml/min/173m2

1.35

143

1317

(3023103) Potassium [Moles/volume] in Serum or Plasma

190

1748

1.56

1.62

25.8

22.7

4.0

4.1

mmol/l

0.17

178

1704

(3010380) Borrelia burgdorferi IgG Ab [Units/volume] in Cerebral spinal fluid

3.63

1.62

1.2

1.1

—

(3019309) Folate [Moles/volume] in Red Blood Cells

433

1.46

1.62

1.8

1079.0

1140.8

nmol/l

0.15

332

(3005785) Creatine kinase.MB [Mass/volume] in Serum or Plasma

211

1.60

1.57

1.8

2.5

5.0

7.8

ug/l

0.84

182

(3014973) Borrelia burgdorferi IgM Ab [Units/volume] in Cerebral spinal fluid

3.38

1.53

1.2

1.1

—

(21494890) Protein electrophoresis panel - 24 hour Urine

2.64

1.52

1.3

2.3

—

(3017446) Testosterone [Moles/volume] in Serum or Plasma

221

1.58

1.52

2.1

2.2

9.7

12.1

nmol/l

0.82

189

(3018010) Neutrophils/100 leukocytes in Blood

791

1.37

1.52

4.8

5.6

60.6

59.6

0.38

736

(3019900) Cholesterol [Moles/volume] in Serum or Plasma

174

1580

1.45

1.51

5.1

4.9

4.2

mmol/l

0.08

136

1420

(3014271) Vancomycin [Susceptibility]

2.91

1.51

3.2

2.3

—

(3016914) Bacteria identified in Cerebral spinal fluid by Culture

3.17

1.44

1.2

1.3

—

(3026493) Urate [Moles/volume] in Serum or Plasma

506

1.40

1.44

3.5

3.0

7611.4

10315.0

umol/l

0.14

430

(3007461) Platelets [#/volume] in Blood

191

1772

1.52

1.42

30.5

27.4

230.1

223.1

e9/l

0.82

180

1721

(3024731) MCV [Entitic volume]

191

1772

1.52

1.42

30.4

27.3

91.8

92.1

0.42

183

1739

(3041096) Erythrocytes [Presence] in Urine by Automated

433

0.65

1.42

4.9

3.6

—

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

2.30

1.42

1.4

1.3

—

(3026361) Erythrocytes [#/volume] in Blood

191

1773

1.51

1.41

30.5

27.3

4.4

4.5

e12/l

0.30

177

1717

(3035941) MCH [Entitic mass]

191

1773

1.51

1.41

30.4

27.2

30.5

30.7

0.78

183

1739

(3000963) Hemoglobin [Mass/volume] in Blood

191

1773

1.51

1.41

30.6

27.5

134.0

135.7

g/l

0.69

183

1737

(3010813) Leukocytes [#/volume] in Blood

191

1773

1.51

1.41

30.6

27.4

7.3

7.1

e9/l

0.64

179

1717

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

630

0.70

1.40

4.8

4.2

—

(3013115) Eosinophils [#/volume] in Blood

103

867

1.35

1.39

5.0

5.6

0.2

e9/l

0.81

756

(3027545) Mycoplasma pneumoniae Ab [Presence] in Serum by Immunoassay

2.65

1.37

1.3

1.4

—

(3044927) Protein electrophoresis panel - Urine

2.65

1.37

1.3

1.2

—

(40760892) CBC W Ordered Manual Differential panel - Blood

326

0.61

1.37

4.7

5.0

—

(3022096) Basophils/100 leukocytes in Blood

773

1.35

1.36

5.4

5.6

0.6

0.49

722

(3037522) Nuclear Ab [Titer] in Serum

162

1.61

1.33

1.2

226.7

352.9

titre

—

(3001308) Cholesterol in LDL [Moles/volume] in Serum or Plasma

177

1626

1.42

1.32

5.6

5.5

2.4

mmol/l

0.12

142

1447

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

138

1.66

1.32

1.9

1.5

—

(3024928) Oxygen saturation in Venous blood

2.14

1.32

2.1

2.8

—

(37019628) Gastrointestinal bacterial pathogens panel - Stool by NAA with probe detection

2.14

1.32

1.9

1.7

—

(3045424) Erythrocytes [Presence] in Urine

2.54

1.31

1.2

1.3

—

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

2.40

1.30

1.1

1.2

—

(3017895) Helicobacter pylori Ab [Units/volume] in Serum

2.13

1.29

1.1

1.5

—

(3044290) Cell count panel - Cerebral spinal fluid

2.34

1.19

1.2

1.3

—

(3010521) Mycoplasma pneumoniae IgM Ab [Presence] in Serum by Immunoassay

2.34

1.19

1.2

1.1

—

(3022621) pH of Urine by Test strip

118

1.67

1.19

2.5

2.4

—

(3048773) Triglyceride [Moles/volume] in Serum or Plasma --fasting

167

1530

1.35

1.18

4.8

4.3

1.3

mmol/l

0.13

130

1352

(40768800) Prostate Pathology biopsy report

1.74

1.17

1.0

1.1

—

(3026782) Osmolality of Urine

448

0.69

1.15

3.1

3.2

546.5

602.2

mosm/kgh2o

0.87

375

(3001604) Monocytes [#/volume] in Blood

837

1.30

1.15

4.8

5.5

0.6

e9/l

0.17

711

(3002256) Pathology report gross observation

237

1.46

1.13

1.2

1.4

—

(3005013) Prostate Specific Ag Free [Mass/volume] in Serum or Plasma

841

1.29

1.10

4.6

3.2

0.7

0.8

ug/l

0.61

597

(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay

1.75

1.08

1.9

2.4

0.3

0.4

u/ml

—

(3006315) Basophils [#/volume] in Blood

843

1.29

1.07

4.8

5.5

0.0

e9/l

0.08

725

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

114

1.63

1.06

1.2

—

(3016888) Borrelia burgdorferi IgG Ab [Units/volume] in Serum

1.78

1.05

1.3

—

49.5

—

(3008909) Norovirus RNA [Presence] in Stool by NAA with probe detection

1.88

1.04

1.3

1.2

—

(3021960) Folate [Moles/volume] in Serum or Plasma

513

1.32

1.03

1.8

1.6

17.7

18.7

nmol/l

0.16

431

(3000093) Morphology [Interpretation] in Blood Narrative

2.20

0.98

1.0

1.3

—

(3013139) Helicobacter pylori Ag [Presence] in Stool

1.78

0.98

1.1

1.3

—

(3018251) Fasting glucose [Moles/volume] in Serum or Plasma

173

1610

1.32

0.98

6.1

5.2

6.1

6.2

mmol/l

1.22

134

1425

(3013650) Neutrophils [#/volume] in Blood by Automated count

111

978

1.27

0.98

6.3

9.6

5.0

4.4

e9/l

1.26

856

(3014765) Yersinia sp identified in Stool by Organism specific culture

1.97

0.98

1.1

1.3

—

(3006418) Campylobacter sp identified in Tissue by Organism specific culture

1.97

0.98

1.1

1.3

—

(3023602) Cholesterol in HDL [Moles/volume] in Serum or Plasma

169

1569

1.31

0.97

5.8

4.8

1.3

mmol/l

0.25

135

1392

(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection

134

1.54

0.95

1.5

1.4

—

(42529406) Shigella sp [Presence] in Stool by Culture

1.92

0.95

1.1

1.2

—

(3008486) Thyroxine (T4) free [Moles/volume] in Serum or Plasma

122

1090

1.26

0.95

3.1

3.0

15.3

15.0

pmol/l

0.81

931

(36033641) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Rapid immunoassay

2.25

0.94

2.3

1.6

—

(3041942) Cyclic citrullinated peptide Ab [Units/volume] in Serum

169

1.47

0.92

1.3

1.2

19.4

u/ml

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

136

1.52

0.90

1.9

1.6

—

(3016881) Enterovirus RNA [Presence] in Specimen by NAA with probe detection

2.10

0.90

1.0

2.1

—

(3004410) Hemoglobin A1c/Hemoglobin.total in Blood

166

1545

1.28

0.88

7.7

7.0

41.3

41.8

mmol/mol

0.27

126

1408

(40761511) CBC panel - Blood by Automated count

178

1672

1.31

0.87

22.5

18.0

—

(3021614) Rheumatoid factor [Units/volume] in Serum or Plasma

190

1.42

0.83

1.3

1.2

12.0

46.4

iu/ml

—

(3019198) Lymphocytes [#/volume] in Blood

854

1.24

0.83

4.9

5.7

1.7

1.8

e9/l

0.89

747

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

139

1.48

0.82

2.0

1.6

—

(3004775) Volume in Urine collected for unspecified duration

0.00

0.79

0.0

2.1

—

476.0

—

(3027456) Digoxin [Moles/volume] in Serum or Plasma

1.69

0.79

3.4

3.1

0.7

1.0

nmol/l

—

(3027945) Reticulocytes/100 erythrocytes in Blood

290

1.33

0.79

2.2

2.0

1.9

1.7

0.36

257

(46235355) HIV 1 and 2 tests - Meaningful Use set

167

1.42

0.77

2.2

1.6

—

(3002173) Hemoglobin [Mass/volume] in Arterial blood

230

0.67

0.77

6.6

8.4

126.1

121.9

g/l

0.32

224

(3024403) Complement+Immunoglobulin [Units/volume] in Red Blood Cells

1.73

0.76

1.3

1.4

—

(1002224) Polysomnography panel

1.87

0.74

1.1

—

(3007853) Bacteria identified in Skin by Aerobe culture

250

1.33

0.71

2.1

1.7

—

(3015399) Transferrin receptor.soluble [Mass/volume] in Serum or Plasma

547

1.24

0.71

1.9

2.0

3.1

mg/l

0.02

466

(3016251) Hemoglobin.gastrointestinal [Presence] in Stool

110

1.49

0.70

2.2

2.6

—

(3012447) Hantavirus puumala IgG Ab [Titer] in Serum

1.87

0.69

1.0

—

(3025023) Rhinovirus RNA [Presence] in Specimen by NAA with probe detection

1.87

0.69

1.0

2.2

—

(3018095) Leukocytes [#/volume] in Urine

704

0.82

0.65

5.6

4.0

84.2

180.0

e6/l

0.46

543

(3006923) Alanine aminotransferase [Enzymatic activity/volume] in Serum or Plasma

181

1724

1.26

0.65

12.4

11.6

25.4

26.0

u/l

0.17

165

1655

(44816559) Phosphatidylethanol [Mass/volume] in Blood

1.74

0.64

1.0

1.1

—

(3022806) Fractional oxyhemoglobin in Capillary blood

1.74

0.64

4.6

1.4

90.5

88.3

—

(3048816) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Blood

140

0.63

0.62

3.9

3.8

1.2

mmol/l

—

125

(36032419) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Immunoassay

1.68

0.62

1.8

1.6

—

(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count

348

1.25

0.61

3.1

0.9

1.2

e6/l

0.43

216

(3017569) Oxygen content in Arterial blood

0.00

0.60

0.0

5.1

—

(4035726)

159

1.35

0.58

1.2

1.5

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

259

1.27

0.56

1.5

1.7

—

(40762366) Oxygen capacity [Volume Fraction] in Arterial blood

122

0.64

0.56

7.6

10.4

—

(40765161) Human bocavirus DNA [Presence] in Specimen by NAA with probe detection

1.64

0.56

1.3

2.0

—

(3029379) Protein.monoclonal band 4 [Mass/volume] in Serum or Plasma by Electrophoresis

1.52

0.55

1.3

3.5

0.0

g/l

—

(46236952) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (MDRD)

144

1.35

0.52

5.9

2.6

42.1

56.4

ml/min/173m2

—

(3000991) Gas panel - Venous blood

189

1.30

0.52

5.2

9.9

—

(3024172) Erythropoietin (EPO) [Units/volume] in Serum or Plasma

1.51

0.52

1.2

1.1

12.3

27.7

u/l

—

(3026008) Bacteria identified in Urine by Culture

508

1.19

0.50

3.4

3.2

—

(3004716) Salmonella sp identified in Stool by Organism specific culture

1.57

0.49

1.1

1.3

—

(3042111) Morphology [Interpretation] in Bone marrow Narrative

1.54

0.49

1.1

1.8

—

(40763571) Iron/Transferrin [Ratio] in Serum or Plasma

311

1.23

0.48

2.8

2.5

21.1

22.1

0.17

266

(3004789) Transferrin [Mass/volume] in Serum or Plasma

331

1.22

0.47

2.6

2.4

2.1

2.2

g/l

1.22

305

(3029937) Albumin [Presence] in Urine by Test strip

475

0.83

0.45

4.6

4.0

0.0

estimate

0.00

150

(3042194) Human metapneumovirus RNA [Presence] in Specimen by NAA with probe detection

1.38

0.44

1.3

1.9

—

(3040853) Adenovirus DNA [Identifier] in Specimen by NAA with probe detection

1.38

0.44

1.3

1.8

—

(3018418) pH of Serum or Plasma

524

0.85

0.42

5.8

4.5

7.4

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

759

1.15

0.42

4.3

3.6

—

(3000494) Fungus identified in Specimen by Culture

214

1.24

0.42

1.2

1.5

—

(4034850)

1.37

0.41

23.6

14.5

—

(3012202) Varicella zoster virus DNA [Presence] in Specimen by NAA with probe detection

0.00

0.41

0.0

1.5

—

(3016750) Collection duration of Urine

0.00

0.41

0.0

2.4

—

497.5

—

(40766800) Mycobacterium tuberculosis stimulated gamma interferon release by CD4+ T-cells [Units/volume] corrected for background in Blood

0.00

0.41

0.0

1.0

—

(46237023) Hepatitis B virus core and surface Ab and surface Ag panel - Serum

1.48

0.40

1.0

1.2

—

(3005570) Glucose [Moles/volume] in Urine

0.00

0.40

0.0

1.4

—

(3044242) Glucose [Moles/volume] in Arterial blood

0.00

0.40

0.0

5.4

—

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

224

0.79

0.39

5.5

3.5

—

(3009542) Hematocrit [Volume Fraction] of Blood

144

1372

1.14

0.38

19.2

20.5

40.1

38.6

0.75

806

(3001784) Prostate Specific Ag Free/Prostate specific Ag.total in Serum or Plasma

123

1161

1.13

0.38

5.4

4.8

18.9

21.6

1.30

622

(3002434) Lupus erythematosus deoxynucleoproteins IgG Ab [Units/volume] in Serum by Immunoassay

1.36

0.37

2.2

1.8

—

(3022948) Iron [Moles/volume] in Serum or Plasma

359

1.17

0.36

2.8

2.4

10.5

12.5

umol/l

1.01

330

(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count

340

1.18

0.36

3.2

3.3

2.4

0.6

e6/l

0.68

209

(3019150) Specific gravity of Urine by Refractometry

359

0.84

0.35

5.9

4.2

1.0

kg/l

—

(36660697) Celiac disease serology panel - Serum

1.36

0.34

1.5

1.3

—

(1616796) Gas panel - Central venous blood

1.34

0.34

7.2

4.4

—

(3014576) Chloride [Moles/volume] in Serum or Plasma

305

0.83

0.34

5.5

7.2

104.8

104.3

mmol/l

0.22

299

(3012544) pH of Venous blood

211

1.21

0.33

2.3

4.3

—

(3000330) Specific gravity of Urine by Test strip

1.32

0.32

2.3

4.8

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

259

1.18

0.32

1.6

1.8

—

(3002582) Erythrocytes [#/volume] in Urine

645

0.88

0.31

4.9

3.6

76.7

174.7

e6/l

0.41

517

(3051714) Fibrin D-dimer FEU [Mass/volume] in Platelet poor plasma

364

0.86

0.30

1.7

1.4

1.7

mg/l

0.32

294

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

151

0.78

0.29

1.7

1.5

—

(3002032) Base excess in Venous blood by calculation

205

1.19

0.29

2.3

4.4

1.9

1.4

mmol/l

0.29

155

(3021879) Hepatitis B virus core Ab [Presence] in Serum

1.31

0.28

1.1

1.4

—

(3039443) Prostate specific Ag panel - Serum or Plasma

1.30

0.28

1.5

1.7

—

(3004248) Sex hormone binding globulin [Moles/volume] in Serum or Plasma

1.28

0.28

1.8

1.6

38.0

48.1

nmol/l

—

(3014162) Mycobacterium tuberculosis DNA [Presence] in Specimen by NAA with probe detection

1.28

0.27

1.8

3.5

—

(3002109) Cholesterol in LDL/Cholesterol in HDL [Mass Ratio] in Serum or Plasma

0.70

0.26

3.4

1.9

—

(3009261) Glucose [Presence] in Urine by Test strip

820

0.91

0.25

4.5

3.8

0.0

estimate

0.00

157

(3011397) Hemoglobin [Presence] in Urine by Test strip

380

1.13

0.25

4.0

3.7

—

(40769539) Bacteria identified based on 16S rRNA gene [Identifier] in Specimen by Sequencing

1.29

0.23

1.0

1.5

—

(3003396) Base excess in Arterial blood by calculation

283

0.87

0.22

4.9

7.5

0.4

1.1

mmol/l

0.31

215

(42868544) Hantavirus puumala IgM Ab [Presence] in Serum or Plasma by Immunofluorescence

1.26

0.22

1.0

—

(3046524) Influenza virus A Ag [Presence] in Nasopharynx by Immunoassay

1.22

0.22

1.4

—

(3043362) Influenza virus B Ag [Presence] in Nasopharynx by Immunoassay

1.22

0.22

1.4

—

(3035350) Ketones [Presence] in Urine by Test strip

804

0.92

0.22

4.4

3.8

0.0

estimate

0.00

165

(3006442) Creatine [Moles/volume] in Serum or Plasma

0.00

0.21

0.0

1.3

—

(3035320) C reactive protein [Mass/volume] in Body fluid

0.00

0.21

0.0

1.9

—

(3041067) Sjogrens syndrome-A extractable nuclear 52kD Ab [Units/volume] in Serum

0.00

0.21

0.0

1.2

—

(3041423) Sjogrens syndrome-A extractable nuclear 60kD Ab [Units/volume] in Serum

0.00

0.21

0.0

1.1

—

(4024509)

0.00

0.21

0.0

1.2

—

(1001509) Gas and Carbon monoxide and Electrolytes panel - Arterial blood

0.00

0.21

0.0

4.4

—

(43055361) Metamyelocytes/Leukocytes [Pure number fraction] in Blood by Manual count

0.00

0.21

0.0

2.8

—

(3038026) Centromere Ab [Units/volume] in Serum

0.00

0.21

0.0

1.1

—

(3021601) Nitrite [Presence] in Urine by Test strip

803

0.92

0.21

5.3

5.0

0.0

estimate

0.00

166

(43534045) MCM6 gene c.-13910C>T and -13915T>G [Identifier] in Blood or Tissue by Molecular genetics method Nominal

1.17

0.21

1.0

—

(3015816) F5 gene p.Arg506Gln [Presence] in Blood or Tissue by Molecular genetics method

0.00

0.21

0.0

1.2

—

(4268621)

0.00

0.21

0.0

1.9

—

(3003031) Transferrin.carbohydrate deficient.disialo/Transferrin.total in Serum or Plasma

136

1.19

0.20

1.4

2.1

1.9

1.8

0.15

102

(3012110) Lysozyme [Mass/volume] in Serum or Plasma

1.23

0.20

1.2

1.6

13.3

16.0

mg/l

—

(3002179) Metamyelocytes/100 leukocytes in Blood

127

1.19

0.20

3.9

4.3

2.3

0.3

—

(3030467) Casts [#/volume] in Urine by Automated count

576

0.92

0.18

4.9

3.5

0.2

0.4

e6/l

1.63

448

(3009508) Creatinine [Moles/volume] in Urine

614

1.08

0.18

4.2

3.3

7.8

7.7

mmol/l

0.05

495

(3021447) Carbon dioxide [Partial pressure] in Venous blood

205

1.14

0.18

2.4

4.4

5.7

5.8

kpa

0.13

194

(3015235) Bicarbonate [Moles/volume] in Capillary blood

1.17

0.16

1.9

2.6

22.8

24.8

mmol/l

—

(3042936) Bacteria identified in Isolate by Culture

313

1.10

0.16

2.2

1.9

—

(3015377) Calcium [Moles/volume] in Serum or Plasma

598

1.07

0.15

2.7

3.8

2.3

mmol/l

0.35

514

(3013721) Aspartate aminotransferase [Enzymatic activity/volume] in Serum or Plasma

520

1.08

0.15

2.9

3.3

39.0

35.7

u/l

0.17

495

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

1.11

0.10

1.0

1.1

—

(3021440) Promyelocytes/100 leukocytes in Blood

136

1.11

0.09

3.9

4.4

0.1

—

(36305247) Microscopic observation [Identifier] in Isolate by Gram stain

1.04

0.08

2.0

1.4

—

(36304419) Bacteria [Presence] in Urine

540

1.05

0.08

4.2

3.5

—

(40758558) Short blood count panel - Blood

413

1.05

0.07

5.2

6.4

—

(40768443) Skin Pathology biopsy report

0.84

0.07

1.1

1.3

—

(40768797) Stomach Pathology biopsy report

214

0.93

0.07

1.4

1.3

—

(3020891) Body temperature

0.86

0.07

4.6

4.0

—

(3009035) Cobalamin (Vitamin B12) [Moles/volume] in Serum or Plasma

435

1.04

0.06

1.6

1.8

176471050.9

15746252.0

pmol/l

0.43

362

(3022145) Colonoscopy Study observation

188

1.07

0.05

1.3

—

(3000492) Spirometry study

128

0.93

0.02

1.2

1.5

—

(3007164) IgA [Mass/volume] in Serum or Plasma

248

0.96

0.02

1.6

1.4

2.4

2.8

g/l

0.62

150

(3003694) ABO and Rh group [Type] in Blood

418

0.98

0.01

1.2

1.3

—

(3012516) Albumin [Mass/volume] in Urine

612

1.02

0.01

4.4

3.4

110.5

242.4

mg/l

0.48

425

(3004119) Hemoglobin [Mass/volume] in Venous blood

134

1.05

0.00

1.6

3.4

131.2

126.0

g/l

0.39

129

(3017181) Myelocytes/100 leukocytes in Blood

144

1.04

0.00

4.0

4.3

1.0

0.9

—

(3027273) Bicarbonate [Moles/volume] in Venous blood

108

1.02

0.00

1.9

3.6

24.1

25.0

mmol/l

0.39

103

(3020682) Albumin/Creatinine [Ratio] in Urine

648

1.00

0.00

5.1

4.2

25.5

11.3

mg/mmol

0.43

431

(3024889) Methemoglobin/Hemoglobin.total in Venous blood

103

0.97

0.00

1.5

3.1

0.6

0.7

—

(3019060) Gas panel - Arterial blood

165

0.97

0.00

2.9

4.0

—

(3024354) Oxygen [Partial pressure] in Venous blood

175

1.03

0.00

2.3

3.2

5.5

4.3

kpa

0.44

164

(3025159) Blasts/100 leukocytes in Blood

125

0.96

0.00

4.6

0.0

0.2

—

(40757349) CD3+CD4+ (T4 helper) cells/CD3+CD8+ (T8 suppressor cells) cells [# Ratio] in Blood

0.00

0.0

2.4

—

(3022907) Direct antiglobulin test.polyspecific reagent [Presence] on Red Blood Cells

0.00

0.0

1.2

—

(3043410) Blood group antigens tested for on Red Blood Cells

0.00

0.0

1.2

—

(40766048) U1 small nuclear ribonucleoprotein 70kD Ab [Units/volume] in Serum by Immunoassay

0.00

0.0

1.1

—

(3051101) Glucose [Moles/volume] in Cord blood

0.00

0.0

4.3

—

(36305771) Cryptosporidium sp DNA [Presence] in Stool by NAA with probe detection

0.00

0.0

1.7

—

(3034988) Calcium [Moles/volume] in Capillary blood

0.00

0.0

1.0

—

1.2

—

(4027681)

0.00

0.0

1.3

—

(3025443) Phadiatop IgE Ab [Units/volume] in Serum

0.00

0.0

1.0

—

(3024263) Appearance of Synovial fluid

0.00

0.0

1.6

—

(3028371) Actinomyces sp identified in Specimen by Organism specific culture

0.00

0.0

1.3

—

(3032773) Endomysium IgG Ab [Titer] in Serum

0.00

0.0

1.0

—

(3011544) Albumin [Mass/volume] in Pleural fluid

0.00

0.0

1.0

—

16.9

—

(3039602) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Capillary blood

0.00

0.0

1.2

—

1.3

—

(3013727) Leukocytes other/100 leukocytes in Blood

0.00

0.0

5.0

—

54.2

—

(3021197) Magnesium Ionized [Moles/volume] in Serum or Plasma

0.00

0.0

1.3

—

(3000081) cloZAPine [Moles/volume] in Serum or Plasma

0.00

0.0

26.8

—

1232.4

—

(21494814) CD8 cells/100 lymphocytes in Specimen

0.00

0.0

1.6

—

(3000924) Streptococcus pyogenes [Presence] in Throat by Organism specific culture

0.00

0.0

1.0

—

(3036535) Thyroglobulin [Mass/volume] in Serum or Plasma

0.00

0.0

3.0

—

(3020073) CD3+CD4+ (T4 helper) cells/CD3+CD8+ (T8 suppressor cells) cells [# Ratio] in Specimen

0.00

0.0

1.7

—

(3024561) Albumin [Mass/volume] in Serum or Plasma

850

1.00

0.00

5.3

5.0

33.6

34.4

g/l

0.51

795

(3015479) Mycobacterium sp identified in Blood by Organism specific culture

0.00

0.0

1.5

—

(3008832) Norclozapine [Moles/volume] in Serum or Plasma

0.00

0.0

19.4

—

841.8

—

(3000208) Alpha tocopherol [Moles/volume] in Serum or Plasma

0.00

0.0

1.7

—

27.0

—

(37020937) Giardia lamblia DNA [Presence] in Stool by NAA with probe detection

0.00

0.0

1.7

—

(3022689) Creatine [Moles/volume] in Urine

0.00

0.0

1.8

—

(42869593) Oxyhemoglobin/Hemoglobin.total [Pure mass fraction] in Capillary blood

0.00

0.0

1.4

—

(3036071) Salmonella sp Ab [Titer] in Serum

0.00

0.0

1.0

—

(3001186) Copper [Moles/volume] in Serum or Plasma

0.00

0.0

1.0

—

17.8

—

(3007821) Glucose [Moles/volume] in Serum or Plasma --baseline

0.00

0.0

1.3

—

9.4

—

(3050238) Crystals [Presence] in Synovial fluid by Light microscopy

0.92

0.00

1.2

—

(3037692) Legionella sp identified in Specimen by Organism specific culture

0.00

0.0

1.8

—

(3025315) Body weight

0.00

0.0

3.8

—

(44806420)

0.00

0.0

2.2

—

(3014891) Appearance of Pleural fluid

0.00

0.0

1.1

—

(3025018) Bordetella pertussis Ab [Titer] in Serum

0.00

0.0

1.4

—

Mortality – FinRegistry

↥

Association

Association between endpoint CD2_BENIGN_PROSTATE and mortality.

Females

No data

Males

Parameter	HR [95% CI]	p-value
CD2_BENIGN_PROSTATE	1.364 [1.17, 1.6]	< 0.001
Birth year	0.986 [0.98, 1.0]	0.004

During the follow-up period (1.1.1998 — 31.12.2019), 550 out of 1196 males with CD2_BENIGN_PROSTATE died.

Mortality risk

Mortality risk for people of age

years, who have CD2_BENIGN_PROSTATE.

N-year risk	Females	Males
1	No data	0.208%
5	No data	1.545%
10	No data	3.859%
15	No data	7.262%
20	No data	12.475%

Relationships between endpoints

↥

Index endpoint: CD2_BENIGN_PROSTATE – Benign neoplasm: Prostate

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Benign neoplasm: Prostate

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

Matched cohort

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints