No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
|
1. Apply sex-specific ruleonly females |
- |
2. Check conditions
|
- |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
3 out of 7 registries used, show all original rules. |
- |
4. Check minimum number of eventsNone |
- |
5. Include endpointsNone |
- |
6. Filter based on genotype QC (FinnGen only)None |
- |
Control definitions (FinnGen only)
- Control exclude
- C3_CANCER, C3_CANCER_WIDE
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF9
- Parent code in ICD-10
- D07
- Name in latin
- Carcinoma in situ penis
Similar endpoints
↥List of similar endpoints to
Carcinoma in situ of vulva
based on the number of shared cases.
Similar with more cases:
- Carcinoma in situ of vulva
- Carcinoma in situ of other and unspecified genital organs
- Carcinoma in situ of other and unspecified genital organs
- In situ neoplasms
- In situ neoplasms
Similar with less cases:
Case counts by codes
↥FinnGen case counts by registry codes:
No upset plot: script not run.
No upset table: script not run.
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 525 | 525 | - |
| Only index persons | 473 | 473 | - |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.02 | 0.02 | - |
| Only index persons | 0.02 | 0.02 | - |
| Median age at first event (years) | |||
| Whole population | - | 56.55 | - |
| Only index persons | - | 55.59 | - |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 266 | 266 | - |
| Unadjusted period prevalence (%) | 0.09 | 0.09 | - |
| Median age at first event (years) | 58.75 | 58.75 | - |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 239
- Matched controls
- 2390
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
LFB00
NOMESCO Finland
Biopsy of vulva or perineum
377.0
202.9
182
20
ULA02
NOMESCO Finland
Kolposcopy
110.0
176.5
209
142
N90.2
ICD-10 Finland
Severe vulvar dysplasia, not elsewhere classified
835.8
159.7
140
*
8077/2-C51.9
ICD-O-3
Squamous intraepithelial neoplasia, high grade of vulva, NOS
+∞
155.8
132
*
XLD00
NOMESCO Finland
Sytologyspecimen from mouth of uterus
23.5
95.8
162
196
LFB10
NOMESCO Finland
Excision of lesion of vulva or perineum
191.9
95.3
94
8
D07.1
ICD-10 Finland
Carcinoma in situ: Vulva
+∞
84.5
76
*
N90.1
ICD-10 Finland
Moderate vulvar dysplasia
1123.0
83.8
77
*
LFC00
NOMESCO Finland
Partial excision of vulva
217.1
64.6
64
*
D06BB10
ATC
imiquimod; topical
29.8
55.1
75
36
LEB00
NOMESCO Finland
Biopsy of vagina
54.1
49.4
58
14
LFB20
NOMESCO Finland
Destruction of lesion of vulva or perineum
119.5
45.7
48
5
LDA20
NOMESCO Finland
Biopsy of vaginal cervix
13.5
42.6
79
84
L90.0
ICD-10 Finland
Lichen sclerosus et atrophicus
23.4
36.0
52
28
R87.6
ICD-10 Finland
Abnormal findings in specimens from female genital organs, abnormal cytological findings
7.4
29.7
79
149
LC2BE
NOMESCO Finland
Transvaginal ultrasound examination of uterus, parametria and lower abdomen
4.8
28.4
146
593
8070/2-C51.9
ICD-O-3
Squamous cell carcinoma in situ, NOS, of vulva, NOS
+∞
26.5
25
*
N90.0
ICD-10 Finland
Mild vulvar dysplasia
101.1
25.2
27
*
A63.0
ICD-10 Finland
Anogenital (venereal) warts
16.5
23.6
38
27
LDA10
NOMESCO Finland
Curettage of cervix uteri
9.7
22.9
48
60
D07AD01
ATC
clobetasol; topical
4.8
22.1
88
260
8071/2-C51.9
ICD-O-3
Differentiated intraepithelial neoplasia of vulva, NOS
+∞
20.1
19
*
115
Kela drug reimbursment
Breast cancer
+∞
20.1
19
*
C50.41
ICD-10 Finland
Malignant tumor of the upper outer quadrant of the mammary gland, ductal tumor
+∞
17.9
17
*
PJA12
NOMESCO Finland
Sentinel node biopsy
+∞
17.9
17
*
N90.4
ICD-10 Finland
Leukoplakia of vulva
36.2
16.0
20
6
WX105
NOMESCO Finland
Surface analgesia on skin or mucosa
5.4
15.8
50
111
LDC03
NOMESCO Finland
Conisation of cervix uteri using diathermy or laser
7.2
15.7
39
63
LEB30
NOMESCO Finland
Destruction of lesion of vaginal mucosa
85.5
14.8
16
*
WF003
NOMESCO Finland
Adjuvant radiotherapy
+∞
14.7
14
*
8500/3-C50.9
ICD-O-3
Infiltrating duct carcinoma, NOS, of breast, NOS
+∞
14.7
14
*
N90.3
ICD-10 Finland
Dysplasia of vulva, unspecified
+∞
13.7
13
*
8077/2-C52.9
ICD-O-3
Squamous intraepithelial neoplasia, high grade of vagina, NOS
148.1
13.6
14
*
N76.6
ICD-10 Finland
Ulceration of vulva
27.6
13.6
18
7
N87.0
ICD-10 Finland
Mild cervical dysplasia
9.4
13.2
27
32
B01AB10
ATC
tinzaparin; parenteral
6.9
12.8
32
52
HAC20
NOMESCO Finland
Total mastectomy
+∞
12.6
12
*
XX3DW
NOMESCO Finland
Time consuming IT work
6.6
11.7
30
51
Z08.0
ICD-10 Finland
Follow-up examination after surgery for malignant neoplasm
+∞
11.5
11
*
D06BB04
ATC
podophyllotoxin; topical
7.5
11.5
27
40
WZC00
NOMESCO Finland
Planning of intervention or health care consultation
2.8
11.4
96
464
H02AB02
ATC
dexamethasone; systemic
18.2
11.4
17
10
HA1AA
NOMESCO Finland
X-ray mammography
6.9
11.3
28
45
WX404
NOMESCO Finland
Intravenous generell anesthesy
3.1
11.1
70
279
T81.4
ICD-10 Finland
Infection following a procedure, not elsewhere classified
4.2
10.9
43
119
HAB40
NOMESCO Finland
Wedge excision of mammary gland
22.7
10.8
15
7
WF002
NOMESCO Finland
Radical radiotherapy
+∞
10.5
10
*
2333B
ICD-9 Finland
Carcinoma in situ of breast and genito-urinary system, Other and unspecified female genital organs[CARCINOMA IN SITU VULVAE]
+∞
10.5
10
*
WX320
NOMESCO Finland
Spinalanesthesy
2.9
10.4
75
325
N90.9
ICD-10 Finland
Noninflammatory disorder of vulva and perineum, unspecified
24.7
10.4
14
6
HA1AE
NOMESCO Finland
Ultrasound examination of mammary glands
6.5
10.2
26
44
N90.8
ICD-10 Finland
Other specified noninflammatory disorders of vulva and perineum
17.7
10.0
15
9
LX1AE
NOMESCO Finland
Gynecological ultrasound examination as part of clinical examination
3.3
9.7
53
191
R87.5
ICD-10 Finland
Abnormal findings in specimens from female genital organs, abnormal microbiological findings
15.9
9.6
15
10
ZX012
NOMESCO Finland
Radiotherapy with large shaped fields - isocentric therapy
104.0
9.5
10
*
8474
FHL
Coagulation, excision, or biopsy of local change (eg, condyloma, tumor) in operating room or anesthesia
22.8
9.5
13
6
L02BA01
ATC
tamoxifen; oral
+∞
9.4
9
*
WB103
NOMESCO Finland
Simple adjuvant cytostatic therapy
+∞
9.4
9
*
130
Kela drug reimbursment
Malignant tumour
+∞
9.4
9
*
NK6QA
NOMESCO Finland
Measurement of bone density from tow or more locations with X-ray
5.5
9.3
27
54
JN4AD
NOMESCO Finland
Body CT examination
8.2
8.8
19
25
WZC20
NOMESCO Finland
Multidisciplinary treatment meeting
8.8
8.7
18
22
N89.0
ICD-10 Finland
Mild vaginal dysplasia
51.9
8.7
10
*
WX002
NOMESCO Finland
Sedation and analgesia
2.8
8.7
64
279
N87.1
ICD-10 Finland
Moderate cervical dysplasia
7.2
8.6
20
30
N89.1
ICD-10 Finland
Moderate vaginal dysplasia
28.7
8.6
11
*
P01AB01
ATC
metronidazole; oral, rectal
2.3
8.6
128
807
8090/3-C44.9
ICD-O-3
Basal cell carcinoma, NOS, of skin, NOS
+∞
8.4
8
*
C54.11
ICD-10 Finland
Adenocarcinoma of the endometrium
+∞
8.4
8
*
L03AA13
ATC
pegfilgrastim; parenteral
+∞
8.4
8
*
128
Kela drug reimbursment
Cancers of female genital organs
+∞
8.4
8
*
C51.01
ICD-10 Finland
Squamous cell carcinoma of the labium majus
+∞
8.4
8
*
A04AA02
ATC
granisetron; systemic, transdermal
+∞
8.4
8
*
TLW99
NOMESCO Finland
Other minor surgical procedure in gynaecology
7.3
8.3
19
28
L02BG04
ATC
letrozole; oral
12.3
8.2
14
12
N87.2
ICD-10 Finland
Severe cervical dysplasia, not elsewhere classified
7.7
8.1
18
25
Y83.8
ICD-10 Finland
Other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
7.0
8.1
19
29
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.2
7.8
105
623
N89.2
ICD-10 Finland
Severe vaginal dysplasia, not elsewhere classified
46.5
7.8
9
*
ZZR00
NOMESCO Finland
Flap of skin
26.0
7.6
10
*
ZXE10
NOMESCO Finland
More than one and less than three hours
2.2
7.5
100
586
J02AC01
ATC
fluconazole; systemic
2.1
7.5
144
992
LWA00
NOMESCO Finland
Repair of wound dehiscence in gynaecological surgery
82.5
7.5
8
*
Y83.9
ICD-10 Finland
Surgical procedure, unspecified as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
8.8
7.4
15
18
YG1BD
NOMESCO Finland
Extensive CT examination of thorax for dose design of radiotherapy
+∞
7.3
7
*
YL1BD
NOMESCO Finland
Extensive CT examination of pelvis for dose design of radiotherapy
+∞
7.3
7
*
PJD52
NOMESCO Finland
Block dissection of axillary lymph nodes
+∞
7.3
7
*
C50.49
ICD-10 Finland
Malignant tumor of the upper outer quadrant of the mammary gland, other or undeterminated histology
+∞
7.3
7
*
WD125
NOMESCO Finland
Demanding cystostatic therapy of methastized malignancy
+∞
7.3
7
*
C50.99
ICD-10 Finland
Breast, unspecified
+∞
7.3
7
*
D05.1
ICD-10 Finland
Intraductal carcinoma in situ
+∞
7.3
7
*
HA003
NOMESCO Finland
Radiotherapy after partial ablation of mammary gland
+∞
7.3
7
*
C51.11
ICD-10 Finland
Squamous cell carcinoma of the labium minus
+∞
7.3
7
*
8077/2-C53.9
ICD-O-3
Squamous intraepithelial neoplasia, high grade of cervix uteri
12.6
7.2
12
10
A03FA01
ATC
metoclopramide; systemic, rectal
2.7
7.1
50
210
TQW40
NOMESCO Finland
Remowal of suture of skin
3.9
7.0
28
79
LX1XE
NOMESCO Finland
Other gynecological ultrasound examination
6.5
6.6
16
26
WX110
NOMESCO Finland
Local anesthesy
2.1
6.5
173
1324
E0000UV
ATC
NA
2.0
6.5
110
705
C50.21
ICD-10 Finland
Malignant tumor of the upper inner quadrant of the mammary gland,ductal tumor
+∞
6.3
6
*
L03AA02
ATC
filgrastim; parenteral
+∞
6.3
6
*
ZX070
NOMESCO Finland
Intensity modified radiotherapy
+∞
6.3
6
*
WD105
NOMESCO Finland
Cystostatic therapy of methastized malignancy
+∞
6.3
6
*
B01AB05
ATC
enoxaparin; parenteral
2.2
6.2
74
407
KH1AE
NOMESCO Finland
Urinary tract ultrasound examination
5.8
6.1
16
29
X16
ICPC
Vulval symptom/complaint
10.4
6.1
11
11
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
2.0
6.1
106
682
D07AB02
ATC
hydrocortisone butyrate; topical
2.1
6.0
83
486
Mortality – FinRegistry
↥Association
Association between endpoint CD2_INSITU_VULVA_EXALLC and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| CD2_INSITU_VULVA_EXALLC | 1.318 [1.01, 1.73] | 0.045 |
| Birth year | 0.995 [0.99, 1.0] | 0.251 |
During the follow-up period (1.1.1998 — 31.12.2019), 88 out of 377 females with CD2_INSITU_VULVA_EXALLC died.
Males
No dataMortality risk
Mortality risk for people of age
years, who have CD2_INSITU_VULVA_EXALLC.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.11% | No data |
| 5 | 0.698% | No data |
| 10 | 1.909% | No data |
| 15 | 3.734% | No data |
| 20 | 6.473% | No data |
Relationships between endpoints
↥Index endpoint: CD2_INSITU_VULVA_EXALLC – Carcinoma in situ of vulva
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data