No definition available.
Drug-induced headache, not elsewhere classified
DRUGADVERS_HEADA_NOT_ELSEW_CLASSIFIED
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519972 |
1. Apply sex-specific ruleNone |
519972 |
2. Check conditionsNone |
519972 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
1 out of 7 registries used, show all original rules. |
208 |
4. Check minimum number of eventsNone |
208 |
5. Include endpointsNone |
208 |
6. Filter based on genotype QC (FinnGen only) |
197 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
- Level in the ICD hierarchy
- C
- First used in FinnGen datafreeze
- DF5
Similar endpoints
↥List of similar endpoints to
Drug-induced headache, not elsewhere classified
based on the number of shared cases.
Similar with more cases:
- Other headache syndromes
- Episodal and paroxysmal disorders
- Neurological diseases
- Neurological diseases, wide definition
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1129 | 777 | 342 |
| Only index persons | 1067 | 749 | 318 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.02 | 0.02 | 0.01 |
| Only index persons | 0.02 | 0.03 | 0.01 |
| Median age at first event (years) | |||
| Whole population | 46.97 | 46.58 | 48.11 |
| Only index persons | 46.83 | 46.39 | 47.85 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 197 | 158 | 39 |
| Unadjusted period prevalence (%) | 0.05 | 0.06 | 0.02 |
| Median age at first event (years) | 48.46 | 47.24 | 53.37 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 208
- Matched controls
- 2080
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
G44.4
ICD-10 Finland
Drug-induced headache, not elsewhere classified
+∞
301.2
208
*
G43.0
ICD-10 Finland
Migraine without aura [common migraine]
22.2
111.9
106
93
G43.3
ICD-10 Finland
Complicated migraine
34.1
89.5
61
25
N03AX11
ATC
topiramate; oral
25.0
84.5
66
38
3007
Kela drug reimbursment
Erenumab and fremanezumab
38.4
77.5
50
17
G43.9
ICD-10 Finland
Migraine, unspecified
13.6
69.7
81
93
N02CC01
ATC
sumatriptan; nasal, systemic, rectal
9.6
60.8
111
222
R51.80
ICD-10 Finland
Headache
8.7
55.9
116
263
N06CA01
ATC
amitriptyline and psycholeptics; systemic
10.3
54.7
78
115
N02CC06
ATC
eletriptan; oral
14.2
52.6
54
50
N02CC07
ATC
frovatriptan; oral
12.4
52.2
60
66
G43
ICD-10 Finland
Migraine
11.2
49.8
62
76
G44.2
ICD-10 Finland
Tension-type headache
7.8
48.6
100
220
N02CC04
ATC
rizatriptan; oral
10.1
46.5
63
86
N02CC05
ATC
almotriptan; oral
10.7
40.4
50
60
N03AG01
ATC
valproic acid; systemic, rectal
10.2
39.8
51
64
G43.1
ICD-10 Finland
Migraine with aura [classical migraine]
8.0
39.7
67
117
N02CC02
ATC
naratriptan; oral
17.6
38.2
33
22
N02CC03
ATC
zolmitriptan; nasal, oral
8.8
36.8
54
80
C09CA06
ATC
candesartan; oral
5.9
36.5
107
316
N02CD01
ATC
erenumab; parenteral
43.4
34.4
42
12
N02CD03
ATC
fremanezumab; systemic
44.6
30.5
37
10
N06AA09
ATC
amitriptyline; systemic
6.6
28.5
55
108
N89
ICPC
Migraine
7.6
24.9
39
61
C08DA01
ATC
verapamil; systemic
9.7
24.7
31
37
N01
ICPC
Headache
5.0
23.4
64
170
C07AA05
ATC
propranolol; systemic
4.2
22.8
92
329
N03AX12
ATC
[U] gabapentin; oral
4.5
22.6
74
226
M01AG02
ATC
tolfenamic acid; oral, rectal
4.4
21.8
75
237
A02BC03
ATC
lansoprazole; oral
4.0
21.5
98
379
N03AX16
ATC
[U] pregabalin
4.0
20.7
88
323
N06AX21
ATC
duloxetine; oral
4.6
20.5
61
172
M03AX01
ATC
botulinum toxin; parenteral
32.7
20.2
26
9
R51
ICD-10 Finland
Headache
6.8
19.9
34
58
G43.8
ICD-10 Finland
Other migraine
19.2
19.9
30
18
N02AX02
ATC
tramadol; systemic, rectal
3.7
19.0
126
612
A03FA01
ATC
metoclopramide; systemic, rectal
3.8
18.8
86
328
Z01.8
ICD-10 Finland
Other specified special examinations
3.9
18.3
74
259
G44.0
ICD-10 Finland
Cluster headache syndrome
25.6
18.2
25
11
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
3.5
17.8
121
590
N05BA01
ATC
diazepam; systemic, rectal
4.3
17.7
56
164
N06AX16
ATC
venlafaxine; oral
4.1
17.5
62
197
H02AB07
ATC
prednisone; oral
4.4
17.5
53
150
H02AB06
ATC
prednisolone; systemic
3.5
16.7
133
706
C07AB02
ATC
metoprolol; systemic
3.9
15.9
59
193
N02CD02
ATC
galcanezumab; parenteral
41.5
15.7
19
5
M03BX02
ATC
tizanidine; oral
4.0
15.1
169
1078
A02BC05
ATC
esomeprazole; systemic
3.2
14.9
117
602
F32.9
ICD-10 Finland
Depressive episode, unspecified
3.9
14.1
49
152
M79.1
ICD-10 Finland
Myalgia
3.5
13.6
60
218
AA1AD
NOMESCO Finland
CT of head and brain
3.2
13.4
75
315
A02BA02
ATC
ranitidine; systemic
3.4
13.2
61
228
N03AE01
ATC
clonazepam; systemic
5.8
12.8
25
48
C07AB07
ATC
bisoprolol; oral
2.9
12.7
113
608
M03BC51
ATC
orphenadrine, combinations; systemic
2.9
12.6
90
430
N02CD06
ATC
rimegepant; oral
138.0
12.6
13
*
R53
ICD-10 Finland
Malaise and fatigue
3.0
12.4
82
375
M01AE03
ATC
ketoprofen; systemic, rectal
2.9
12.4
100
510
A02BC02
ATC
pantoprazole; systemic
3.4
12.2
164
1092
D01
ICPC
Abdominal pain/cramps general
3.7
12.0
45
146
N06AB03
ATC
fluoxetine; oral
3.6
11.9
45
147
N06AX11
ATC
mirtazapine; oral
2.8
11.6
98
507
F32.10
ICD-10 Finland
Moderate depressive episode without somatic syndrome
3.8
11.4
39
119
N05CF02
ATC
zolpidem; oral
3.1
11.1
57
225
N05AH04
ATC
quetiapine; oral
3.0
10.7
61
255
N03AX09
ATC
lamotrigine; oral
4.7
10.6
26
61
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.8
10.6
73
338
N06AB04
ATC
citalopram; systemic
2.9
10.3
64
279
M01AE02
ATC
naproxen; oral, rectal
2.8
10.3
152
1017
R42
ICD-10 Finland
Dizziness and giddiness
2.9
10.3
64
280
N02CA52
ATC
ergotamine, combinations excl. psycholeptics; oral
15.6
10.2
16
11
L01
ICPC
Neck symptom/complaint
3.0
10.1
55
223
SHB00
NOMESCO Finland
Preparing and fitting the occlusal splint in the mouth
3.2
10.1
47
174
D06
ICPC
Abdominal pain localized other
3.8
9.9
33
98
F33.10
ICD-10 Finland
Recurrent depression, moderate episode without somatic syndrome
4.3
9.8
27
70
N02CA01
ATC
dihydroergotamine; nasal, systemic
57.8
9.7
11
*
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
3.7
9.7
34
105
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
2.5
9.5
115
689
A06AC01
ATC
ispaghula (psylla seeds); oral
2.6
9.5
72
347
G44.8
ICD-10 Finland
Other specified headache syndromes
14.6
9.3
15
11
N06AX12
ATC
bupropion; oral
3.8
9.3
31
92
R10.3
ICD-10 Finland
Pain localized to other parts of lower abdomen
2.6
9.3
79
402
N02CX04, ,
ATC
10.8
9.2
17
17
N05BA04
ATC
oxazepam; oral
2.5
8.9
76
386
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
3.2
8.8
39
140
G43.2
ICD-10 Finland
Status migrainosus
28.9
8.6
11
*
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
3.2
8.5
38
137
LC2AE
NOMESCO Finland
Ultrasound examination of uterus and parametria
3.0
8.3
41
156
M03BC01
ATC
orphenadrine (citrate); systemic
2.4
8.2
74
383
R07.4
ICD-10 Finland
Chest pain, unspecified
2.5
8.2
68
339
N06AA10
ATC
nortriptyline; systemic
7.8
8.2
18
25
N05CD07
ATC
temazepam; oral
3.6
8.2
29
90
Z71.8
ICD-10 Finland
Other specified counselling
2.4
8.1
87
487
N06AB06
ATC
sertraline; oral
3.0
8.0
39
147
WZC00
NOMESCO Finland
Treatment plan or consultation
2.3
8.0
92
530
R10.1
ICD-10 Finland
Pain localized to upper abdomen
2.6
7.9
57
265
NA3BG
NOMESCO Finland
Lumbar spine MRI examination with high intensity magnet
3.3
7.7
31
104
N02AJ06
ATC
codeine and paracetamol; systemic
2.2
7.6
109
684
M53.0
ICD-10 Finland
Cervicocranial syndrome
3.0
7.6
37
140
KC1EE
NOMESCO Finland
Ultrasound measurement of residual urine
3.5
7.6
27
84
N02BE01
ATC
paracetamol; systemic, rectal
5.3
7.5
198
1642
P03
ICPC
Feeling depressed
3.0
7.4
37
142
AA1BG
NOMESCO Finland
Standard MRI examination of brain with high intensity magnet
3.1
7.3
33
119
F32.2
ICD-10 Finland
Severe depressive episode without psychotic symptoms
3.5
7.1
26
82
P01AB01
ATC
metronidazole; oral, rectal
2.2
7.1
104
652
R03DC03
ATC
montelukast; oral
2.6
7.1
49
222
H02AB04
ATC
methylprednisolone; systemic
2.7
7.1
42
176
R51.81
ICD-10 Finland
Facial pain NOS
8.0
7.0
15
20
A06AD11
ATC
lactulose; oral
3.0
7.0
34
128
N05CF01
ATC
zopiclone; oral
2.2
6.9
76
424
M01AB05
ATC
diclofenac; systemic, rectal
2.4
6.9
154
1138
Z76.0
ICD-10 Finland
Issue of repeat prescription
2.3
6.8
67
356
L03
ICPC
Low back symptom/complaint
2.2
6.7
73
404
T78.4
ICD-10 Finland
Allergy, unspecified
4.1
6.7
19
50
R4110
NOMESCO Finland
Physiotherapy
2.3
6.6
66
353
J01MA02
ATC
ciprofloxacin; systemic
2.1
6.5
88
531
N06AB10
ATC
escitalopram; oral
2.3
6.4
63
334
R01AD58
ATC
fluticasone, combinations; nasal
2.2
6.4
67
365
SAA04
NOMESCO Finland
Special examination of mouth
3.9
6.4
19
52
K07.60
ICD-10 Finland
Snapping jaw
3.3
6.3
25
83
K52.9
ICD-10 Finland
Noninfective gastroenteritis and colitis, unspecified
4.4
6.2
16
39
N06AX03
ATC
mianserin; oral
4.4
6.2
16
39
R20.2
ICD-10 Finland
Paraesthesia of skin
3.2
6.2
25
84
J45.9
ICD-10 Finland
Asthma, unspecified
2.4
6.2
50
243
R11
ICD-10 Finland
Nausea and vomiting
3.0
6.2
29
107
A03FA02
ATC
cisapride; oral, rectal
3.3
6.1
24
79
N05AA02
ATC
levomepromazine; systemic
5.9
6.1
16
29
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
2.1
6.1
96
609
UJF45
NOMESCO Finland
Flexible sigmoidoscopy with biopsy
3.4
6.1
23
74
XF400
NOMESCO Finland
ECG with 12 standard connections
2.7
6.1
37
157
K59.0
ICD-10 Finland
Constipation
3.8
6.0
19
54
Z03.3
ICD-10 Finland
Observation for suspected nervous system disorder
3.6
6.0
20
59
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
126
724
2.88
12.41
8.3
5.7
1.21
1.22
mmol/l
0.31
111
609
82
379
2.92
12.15
2.5
2.0
2.86
2.87
mg/l
0.01
68
325
135
839
2.74
10.86
4.4
2.9
70.22
82.42
ug/l
0.90
129
784
178
1289
3.64
10.66
4.7
3.9
9.77
10.17
mm/h
0.16
172
1194
107
599
2.62
10.57
2.2
1.8
95.17
98.95
pmol/l
0.38
53
310
111
649
2.52
9.79
4.4
4.3
37.20
36.36
g/l
0.93
104
613
42
154
3.16
9.12
3.1
2.2
27.22
27.44
u/l
0.04
37
128
111
669
2.41
8.90
6.2
4.9
1.21
1.22
mmol/l
0.29
104
609
77
394
2.52
8.86
1.9
1.7
0.85
0.75
mg/l
0.17
55
305
146
1001
2.54
8.69
11.0
9.2
3.75
4.02
e9/l
1.15
133
888
180
1384
3.23
8.27
5.8
4.1
14.29
14.53
pmol/l
0.67
172
1286
81
444
2.35
7.84
1.5
1.2
0.51
1.76
u/ml
1.76
16
138
52
232
2.66
7.83
3.7
2.4
6.31
2.99
e6/l
0.90
28
123
84
469
2.33
7.78
3.4
2.1
131.35
341.23
u/l
0.83
79
450
52
254
2.40
6.38
3.3
2.3
1.51
0.96
e6/l
0.64
29
144
17
43
4.22
6.30
1.2
1.1
3.00
2.97
e6/l
0.01
11
35
194
1631
3.81
6.23
7.0
4.8
1.66
2.52
mu/l
0.63
186
1514
21
63
3.60
6.18
1.7
1.6
—
—
—
0
0
93
588
2.05
5.94
3.0
3.4
14.37
38.42
ng/l
1.64
39
346
90
563
2.06
5.91
4.0
2.8
—
—
—
0
0
166
1303
2.36
5.90
9.2
6.8
73.11
76.34
u/l
0.68
158
1217
24
82
3.18
5.79
1.3
2.7
36.17
40.67
u/l
0.58
24
74
54
279
2.26
5.78
2.6
2.7
2.41
2.43
mmol/l
0.95
47
244
35
148
2.64
5.78
8.5
4.9
104.14
103.68
mmol/l
0.21
35
148
50
251
2.31
5.72
1.6
1.6
1120.58
1230.85
nmol/l
0.33
39
188
63
363
2.06
5.05
2.4
2.9
841.58
700.23
ng/l
0.15
50
306
73
449
1.96
4.85
3.5
2.5
0.05
0.37
e6/l
3.56
51
335
61
354
2.02
4.76
1.6
1.5
21.18
21.56
nmol/l
0.08
55
302
60
351
2.00
4.56
1.3
1.3
12.62
35.28
iu/ml
2.73
16
118
(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection
8
9
9.19
4.32
1.4
1.2
—
—
—
0
0
24
97
2.67
4.31
4.5
2.5
4.72
4.63
kpa
0.06
24
97
7
6
12.01
4.30
1.4
1.2
—
—
—
0
0
188
1628
2.61
4.25
15.8
10.4
87.08
87.37
ml/min/173m2
0.07
168
1320
49
275
2.02
4.15
5.7
3.2
56.46
106.14
ng/l
0.47
28
176
7
7
10.29
4.04
1.1
1.1
—
—
%
—
0
0
24
102
2.53
3.91
2.7
1.6
—
—
—
0
0
198
1775
3.40
3.89
21.2
11.7
16.71
19.51
mg/l
0.86
167
1344
27
122
2.39
3.87
1.3
1.3
105.73
310.90
u/ml
0.50
27
107
18
67
2.85
3.77
1.9
1.4
—
—
—
0
0
159
1313
1.90
3.75
4.3
3.5
—
—
—
0
0
122
932
1.75
3.75
6.5
3.8
6.15
6.46
mmol/l
0.96
116
852
51
303
1.91
3.64
1.5
1.7
463.39
434.20
pmol/l
0.39
44
266
15
53
2.97
3.43
3.7
3.1
24.12
24.47
mmol/l
0.15
15
53
40
224
1.97
3.38
2.1
1.7
—
—
—
0
0
77
538
1.68
3.14
2.2
3.0
2.32
2.35
mmol/l
1.25
66
488
185
1642
2.15
3.07
4.3
4.0
5.53
5.75
mmol/l
3.06
175
1531
16
63
2.67
3.03
1.3
1.2
—
—
—
0
0
200
1857
3.00
3.01
13.6
9.2
25.33
24.95
u/l
0.10
200
1802
5
5
10.20
2.99
1.0
1.2
—
—
—
0
0
53
339
1.76
2.94
1.3
1.3
1.22
7.24
u/ml
2.32
24
151
15
58
2.71
2.94
1.9
1.7
—
—
—
0
0
108
836
1.61
2.87
4.9
3.4
0.00
0.00
estimate
-0.00
27
180
108
842
1.59
2.74
5.0
3.4
0.00
0.00
estimate
-0.00
23
165
107
833
1.59
2.73
7.2
4.6
0.00
0.01
estimate
0.50
24
171
12
41
3.04
2.67
1.4
1.3
338.29
304.36
ug/g
—
7
20
9
25
3.71
2.60
1.2
1.2
—
—
—
0
0
147
1241
1.63
2.60
3.5
2.8
35.46
39.98
u/l
0.57
142
1177
23
116
2.10
2.57
1.9
2.1
0.22
0.22
g/l
0.21
17
111
5
7
7.28
2.56
2.0
1.9
103.80
115.14
%
—
5
7
28
153
1.96
2.53
1.3
1.2
36.66
151.08
iu/ml
—
8
62
190
1729
2.14
2.53
4.8
4.3
2.89
2.85
mmol/l
0.27
182
1613
11
37
3.08
2.53
1.3
1.5
—
—
—
0
0
15
63
2.49
2.52
1.3
1.2
—
—
—
0
0
181
1622
1.89
2.50
3.7
3.5
1.31
1.25
mmol/l
0.64
171
1502
5
8
6.37
2.38
1.4
1.0
2397.80
2080.38
miu/ml
—
5
8
7
17
4.22
2.38
1.1
1.1
—
—
—
0
0
14
59
2.47
2.35
1.6
1.8
—
—
—
0
0
87
664
1.53
2.32
9.1
9.7
1.24
1.13
inr
0.39
25
224
15
66
2.37
2.30
1.5
2.0
—
—
—
0
0
7
18
3.99
2.27
1.1
1.1
—
—
—
0
0
7
18
3.99
2.27
1.3
1.2
—
—
—
0
0
186
1694
1.93
2.25
4.2
3.9
1.48
1.52
mmol/l
0.57
176
1582
24
130
1.96
2.23
1.4
1.3
24.82
26.08
iu/l
0.07
19
115
171
1524
1.69
2.19
4.7
4.8
36.96
38.80
mmol/mol
2.54
163
1438
7
19
3.77
2.17
1.3
1.1
—
—
—
0
0
7
20
3.58
2.07
1.3
1.1
—
—
—
0
0
14
65
2.24
1.93
7.1
2.9
53.90
50.01
%
0.24
14
65
55
394
1.54
1.91
2.1
2.5
5803.08
6443.47
umol/l
0.04
49
351
40
266
1.62
1.90
2.4
1.9
—
—
—
0
0
7
22
3.26
1.89
1.1
1.3
—
—
—
0
0
58
422
1.52
1.88
1.8
1.5
—
—
—
0
0
185
1704
1.77
1.84
4.4
3.9
4.82
4.79
mmol/l
0.16
177
1599
31
196
1.68
1.78
2.5
2.3
3.91
6.44
umol/l
1.67
23
170
9
36
2.57
1.76
1.1
1.3
—
—
—
0
0
5
13
3.91
1.72
1.2
1.2
—
—
—
0
0
16
83
2.01
1.70
2.0
1.3
—
—
—
0
0
6
19
3.22
1.67
1.7
1.2
—
—
—
0
0
6
19
3.22
1.67
1.7
1.2
—
—
—
0
0
6
19
3.22
1.67
1.7
1.2
—
—
—
0
0
10
41
2.51
1.67
1.1
1.3
—
—
—
0
0
11
49
2.31
1.66
5.4
3.4
24.56
25.05
mmol/l
0.34
11
49
12
56
2.21
1.64
1.8
1.1
—
—
—
0
0
5
14
3.63
1.62
1.2
1.3
—
72.20
—
0
5
11
50
2.27
1.60
2.1
1.4
—
—
—
0
0
5
16
3.17
1.44
1.0
1.1
—
—
—
0
0
5
16
3.17
1.44
1.6
1.3
—
—
—
0
0
82
669
1.37
1.39
5.0
3.5
—
—
—
0
0
24
152
1.65
1.39
2.6
1.7
—
—
—
0
0
6
23
2.65
1.37
1.0
1.2
—
1.20
—
0
5
5
17
2.99
1.36
1.2
1.2
—
—
—
0
0
12
61
2.03
1.35
3.4
2.6
0.71
0.70
%
0.05
12
61
41
297
1.47
1.34
2.4
2.0
—
—
—
0
0
8
34
2.41
1.30
1.5
1.4
—
—
—
0
0
5
18
2.82
1.29
1.6
1.2
—
—
—
0
0
5
18
2.82
1.29
1.6
1.2
—
—
—
0
0
5
18
2.82
1.29
1.0
1.1
—
—
—
0
0
58
452
1.39
1.29
4.9
3.8
0.00
0.01
estimate
0.50
23
168
8
36
2.27
1.25
1.1
1.1
—
—
—
0
0
5
19
2.67
1.22
1.6
1.6
—
—
—
0
0
5
19
2.67
1.22
1.6
1.6
—
—
—
0
0
5
19
2.67
1.22
1.6
1.6
—
—
—
0
0
5
19
2.67
1.22
1.6
1.6
—
—
—
0
0
17
102
1.73
1.20
3.8
2.1
53.00
3424.08
u/l
—
6
32
19
119
1.66
1.16
1.3
1.3
—
—
—
0
0
203
1966
2.35
1.16
29.9
17.6
133.44
134.53
g/l
0.64
203
1937
12
65
1.90
1.16
3.4
2.6
1.68
1.20
%
0.48
12
65
5
20
2.54
1.16
1.6
1.5
—
—
—
0
0
5
20
2.54
1.16
1.6
1.5
—
—
—
0
0
5
20
2.54
1.16
1.0
1.2
—
—
—
0
0
10
52
1.97
1.08
2.7
2.7
—
—
—
0
0
10
52
1.97
1.08
1.1
1.3
—
—
—
0
0
5
22
2.30
1.04
1.6
1.2
—
—
—
0
0
17
109
1.61
0.97
1.2
1.0
—
—
—
0
0
32
422
0.71
0.96
1.5
1.4
—
—
—
0
0
6
27
2.26
0.94
1.5
2.0
—
—
—
0
0
22
152
1.50
0.92
2.7
1.7
—
—
—
0
0
167
1565
1.34
0.90
25.8
13.8
13.98
14.57
%
1.24
167
1548
8
42
1.94
0.89
1.5
1.3
—
—
—
0
0
11
65
1.73
0.84
1.6
1.6
—
—
—
0
0
26
192
1.40
0.80
4.5
3.9
21.81
21.29
%
0.08
14
77
25
184
1.41
0.78
7.4
6.3
—
—
—
0
0
0
27
0.00
0.78
0.0
3.3
—
53.95
—
0
27
20
143
1.44
0.73
13.3
5.2
11.33
12.73
kpa
1.07
20
136
20
143
1.44
0.73
13.5
5.2
5.05
5.17
kpa
0.36
20
136
45
368
1.28
0.72
4.8
2.1
—
—
—
0
0
5
26
1.95
0.71
2.6
1.4
—
—
—
0
0
5
26
1.95
0.71
2.6
1.4
—
—
—
0
0
5
27
1.87
0.69
1.0
1.1
—
—
—
0
0
18
128
1.44
0.68
4.6
2.8
72.92
75.94
ml/min/173m2
0.19
12
52
48
401
1.26
0.66
2.7
3.5
9.75
7.79
mg/mmol
0.09
29
249
9
61
1.50
0.54
1.2
1.7
—
—
—
0
0
23
180
1.31
0.52
1.9
1.7
—
—
—
0
0
7
46
1.54
0.49
1.4
1.3
—
—
—
0
0
23
184
1.28
0.46
3.5
4.1
34.47
32.52
%
0.28
17
126
7
51
1.39
0.44
1.7
1.4
—
—
—
0
0
5
32
1.58
0.42
1.6
1.3
—
—
—
0
0
5
32
1.58
0.42
3.8
4.3
62.60
60.63
%
—
5
32
11
149
0.72
0.41
2.1
3.2
—
—
—
0
0
0
15
0.00
0.41
0.0
1.2
—
—
—
0
0
11
84
1.33
0.30
1.0
1.5
—
—
—
0
0
17
139
1.24
0.30
1.9
1.6
—
—
—
0
0
11
86
1.29
0.26
1.6
1.5
537.64
280.99
mu/l
0.38
11
79
11
87
1.28
0.25
3.6
7.4
23.46
24.91
mmol/l
0.75
11
81
84
794
1.10
0.24
4.2
2.4
—
—
—
0
0
0
11
0.00
0.21
0.0
2.4
—
—
—
0
0
0
12
0.00
0.21
0.0
1.5
—
15.64
—
0
12
0
14
0.00
0.20
0.0
1.3
—
—
—
0
0
6
53
1.14
0.19
1.3
1.5
—
—
—
0
0
9
81
1.12
0.15
1.2
1.5
—
—
—
0
0
9
81
1.12
0.15
1.3
1.5
—
—
—
0
0
9
81
1.12
0.15
1.2
1.5
—
—
—
0
0
9
85
1.06
0.07
3.8
1.7
—
—
—
0
0
9
87
1.04
0.07
1.4
1.6
—
—
—
0
0
11
100
1.11
0.05
1.9
1.4
—
—
—
0
0
21
199
1.06
0.04
1.6
1.7
—
—
—
0
0
15
145
1.04
0.00
1.6
1.6
—
—
—
0
0
0
8
0.00
0.00
0.0
1.6
—
—
—
0
0
0
8
0.00
0.00
0.0
1.4
—
—
—
0
0
0
8
0.00
0.00
0.0
2.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
7.6
—
—
—
0
0
6
68
0.88
-0.00
1.7
1.9
—
—
—
0
0
8
79
1.01
-0.00
23.4
3.4
24.49
24.62
mmol/l
—
8
79
0
9
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.5
—
205.00
—
0
6
0
6
0.00
-0.00
0.0
1.0
—
15.52
—
0
6
0
7
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
4.2
—
—
—
0
0
0
9
0.00
-0.00
0.0
4.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint DRUGADVERS_HEADA_NOT_ELSEW_CLASSIFIED and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| DRUGADVERS_HEADA_NOT_ELSEW_CLASSIFIED | 1.32 [1.0, 1.74] | 0.046 |
| Birth year | 0.995 [0.99, 1.0] | 0.258 |
During the follow-up period (1.1.1998 — 31.12.2019), 76 out of 665 females with DRUGADVERS_HEADA_NOT_ELSEW_CLASSIFIED died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| DRUGADVERS_HEADA_NOT_ELSEW_CLASSIFIED | 1.614 [1.08, 2.4] | 0.019 |
| Birth year | 0.989 [0.98, 1.0] | 0.076 |
During the follow-up period (1.1.1998 — 31.12.2019), 56 out of 305 males with DRUGADVERS_HEADA_NOT_ELSEW_CLASSIFIED died.
Mortality risk
Mortality risk for people of age
years, who have DRUGADVERS_HEADA_NOT_ELSEW_CLASSIFIED.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.147% | 0.348% |
| 5 | 0.718% | 1.909% |
| 10 | 1.867% | 4.967% |
| 15 | 3.603% | 9.259% |
| 20 | 6.513% | 15.684% |
Relationships between endpoints
↥Index endpoint: DRUGADVERS_HEADA_NOT_ELSEW_CLASSIFIED – Drug-induced headache, not elsewhere classified
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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