parathyroid disease: A disease involving the parathyroid gland.
Disorders of parathyroid gland, other and/or unspecified
DOID EFO Endpoint Browser PheWeb
E4_PARANAS
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519972 |
1. Apply sex-specific ruleNone |
519972 |
2. Check conditionsNone |
519972 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
247 |
4. Check minimum number of eventsNone |
247 |
5. Include endpointsNone |
247 |
6. Filter based on genotype QC (FinnGen only) |
242 |
Control definitions (FinnGen only)
- Control exclude
- E4_ENDOGLAND
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
Similar endpoints
↥List of similar endpoints to
Disorders of parathyroid gland, other and/or unspecified
based on the number of shared cases.
Similar with more cases:
- Disorders of parathyroid gland
- Disorders of other endocrine glands
- Endocrine, nutritional and metabolic diseases
- Any operation in hilmo
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1856 | 1425 | 415 |
| Only index persons | 1503 | 1173 | 330 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.03 | 0.04 | 0.01 |
| Only index persons | 0.04 | 0.04 | 0.01 |
| Median age at first event (years) | |||
| Whole population | 64.79 | 65.50 | 62.14 |
| Only index persons | 63.64 | 64.58 | 60.30 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 242 | 189 | 53 |
| Unadjusted period prevalence (%) | 0.06 | 0.07 | 0.02 |
| Median age at first event (years) | 59.94 | 60.12 | 59.33 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 246
- Matched controls
- 2460
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
E21.5
ICD-10 Finland
Disorder of parathyroid gland, unspecified
+∞
200.5
164
*
E21.09
ICD-10 Finland
Other primary hyperparathyroidism
+∞
159.2
135
*
BBA30
NOMESCO Finland
Excision of lesion of parathyroid gland
+∞
69.1
63
*
E21.3
ICD-10 Finland
Hyperparathyroidism, unspecified
404.5
63.5
61
*
E21.4
ICD-10 Finland
Other specified disorders of parathyroid gland
+∞
59.9
55
*
BBA40
NOMESCO Finland
Subtotal parathyroidectomy
716.5
59.3
56
*
A11CC03
ATC
alfacalcidol; systemic
24.6
57.9
43
21
E21.0
ICD-10 Finland
Primary hyperparathyroidism
344.0
55.6
54
*
NK6QA
NOMESCO Finland
Measurement of bone density from two or more locations with X-ray
7.4
34.9
59
101
E83.50
ICD-10 Finland
Hypercalcemia
54.1
31.6
37
8
E21.2
ICD-10 Finland
Other hyperparathyroidism
+∞
29.8
28
*
106
Kela drug reimbursment
Hypoparathyroidism
+∞
28.7
27
*
H05BX01
ATC
cinacalcet; oral
+∞
28.7
27
*
E21
ICD-10 Finland
Hyperparathyroidism and other disorders of parathyroid gland
+∞
28.7
27
*
A12AA04
ATC
calcium carbonate; oral
37.8
26.3
33
10
N18.9
ICD-10 Finland
Chronic kidney disease, unspecified
6.3
23.6
44
82
321
Kela drug reimbursment
Paricalcitol and cinacalcet
252.5
23.0
23
*
A12AA06
ATC
calcium lactate gluconate; oral
+∞
19.0
18
*
BBA20
NOMESCO Finland
Exploration of parathyroid gland
+∞
15.8
15
*
EP1AE
NOMESCO Finland
Neck ultrasound examination
5.2
15.5
34
73
A11CC02
ATC
dihydrotachysterol; oral
159.1
14.6
15
*
M14.1*E21.5
ICD-10 Finland
Crystal arthropathy in hyperparathyroidism
+∞
13.7
13
*
D35.1
ICD-10 Finland
Benign neoplasm: Parathyroid gland
147.8
13.6
14
*
N18.8
ICD-10 Finland
Other chronic renal failure
11.0
12.8
24
24
205
Kela drug reimbursment
Chronic hypertension
2.7
12.6
105
534
Z71.3
ICD-10 Finland
Dietary counselling and surveillance
6.3
12.5
22
38
123
Kela drug reimbursment
Chronic disorders of vitamin D metabolism
14.4
12.2
20
15
E20.9
ICD-10 Finland
Hypoparathyroidism, unspecified
125.6
11.5
12
*
Z49.1
ICD-10 Finland
Extracorporeal dialysis
26.5
11.3
15
6
196
Kela drug reimbursment
Paricalcitol and cinacalcet
+∞
10.5
10
*
25298
ICD-8 Finland
Diseases of parathyroid gland, Alii definiti
+∞
10.5
10
*
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
2.4
10.3
132
801
138
Kela drug reimbursment
Severe anaemia associated with chronic renal failure
12.0
10.2
18
16
E83.51
ICD-10 Finland
Hypocalcemia
21.1
9.9
14
7
WZC30
NOMESCO Finland
Teaching
2.8
9.8
57
237
M04AA01
ATC
allopurinol; systemic
2.9
9.8
52
206
E89.2
ICD-10 Finland
Postprocedural hypoparathyroidism
57.3
9.7
11
*
AA4CG
NOMESCO Finland
Extensive MRI examination of sella turcica with high intensity magnet
103.9
9.5
10
*
E34.9
ICD-10 Finland
Endocrine disorder, unspecified
+∞
9.4
9
*
127
Kela drug reimbursment
Transplant complication
16.4
9.1
14
9
190
Kela drug reimbursment
Lanthanum carbonate, sevelamer and sucroferric oxyhydroxide
38.2
9.1
11
*
Z94.0
ICD-10 Finland
Kidney transplant status
19.5
9.0
13
7
N18.5
ICD-10 Finland
Chronic kidney disease, stage 5
51.9
8.7
10
*
V03AE02
ATC
sevelamer; oral
51.9
8.7
10
*
C03CA01
ATC
furosemide; systemic
2.2
8.7
112
668
M81.9
ICD-10 Finland
Osteoporosis, unspecified
3.7
8.7
29
86
M05BX04
ATC
denosumab; parenteral
3.5
8.6
32
102
TK800
NOMESCO Finland
Hemodialysis
13.4
8.5
14
11
E21.1
ICD-10 Finland
Secondary hyperparathyroidism, not elsewhere classified
93.1
8.5
9
*
L04AA06
ATC
mycophenolic acid; systemic
11.3
8.4
15
14
E20.8
ICD-10 Finland
Other hypoparathyroidism
+∞
8.4
8
*
KAS10
NOMESCO Finland
Allogenic transplantation of kidney from cadaver donor
22.9
8.1
11
5
UJF32
NOMESCO Finland
Coloscopy
2.2
7.9
88
491
D50.9
ICD-10 Finland
Iron deficiency anaemia, unspecified
3.3
7.8
32
108
D44.8
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Pluriglandular involvement
46.5
7.8
9
*
WX408
NOMESCO Finland
General anesthesy, balanced
2.3
7.7
81
440
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.2
7.7
96
560
N18.0
ICD-10 Finland
End-stage renal disease
25.9
7.6
10
*
M81.0
ICD-10 Finland
Postmenopausal osteoporosis
4.3
7.5
20
50
Q61.2
ICD-10 Finland
Polycystic kidney, autosomal dominant
82.5
7.5
8
*
C02AC05
ATC
moxonidine; oral
4.1
7.4
21
55
BBA70
NOMESCO Finland
Implantation or transplantation of parathyroid gland
+∞
7.3
7
*
25299
ICD-8 Finland
Diseases of parathyroid gland, Other and unspecified
+∞
7.3
7
*
E20.0
ICD-10 Finland
Idiopathic hypoparathyroidism
+∞
7.3
7
*
C08CA01
ATC
amlodipine; oral
2.1
7.2
126
829
A41.9
ICD-10 Finland
Sepsis, unspecified
4.6
7.1
17
39
M10.9
ICD-10 Finland
Gout, unspecified
3.5
6.9
25
78
M05BA04
ATC
alendronic acid; oral
2.6
6.8
44
191
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.0
6.8
134
914
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
2.6
6.7
42
180
H03AA01
ATC
levothyroxine sodium; systemic
2.1
6.6
79
449
B03XA02
ATC
darbepoetin alfa; parenteral
7.7
6.5
14
19
E89.01
ICD-10 Finland
Postsurgical hypothyroidism
8.5
6.4
13
16
PBL10
NOMESCO Finland
Construction of arteriovenous fistula from radial artery
18.6
6.3
9
5
Z49.0
ICD-10 Finland
Preparatory care for dialysis
18.6
6.3
9
5
E26.0
ICD-10 Finland
Primary hyperaldosteronism
+∞
6.3
6
*
N19
ICD-10 Finland
Unspecified kidney failure
3.8
6.2
19
53
I10
ICD-10 Finland
Essential (primary) hypertension
2.1
6.1
180
1392
UKC02
NOMESCO Finland
Cystoscopy
2.4
6.0
46
216
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
105
167
10.22
69.69
5.9
2.8
121.68
73.89
ng/l
2.76
90
143
99
248
6.01
40.16
10.3
4.5
1.08
1.05
mmol/l
0.48
92
223
193
1093
4.55
23.35
17.8
6.0
1.26
1.22
mmol/l
5.44
154
929
167
902
3.65
20.60
4.5
2.2
80.46
80.71
nmol/l
0.04
159
786
176
1006
3.63
19.34
13.6
5.2
1.26
1.22
mmol/l
5.51
169
914
154
1041
2.28
8.82
18.0
13.9
1.28
1.26
inr
0.11
70
310
27
76
3.87
8.67
1.7
3.9
32.04
25.53
mg/l
0.68
16
59
27
76
3.87
8.67
1.7
3.9
37.91
149.68
mg/l
0.71
16
60
141
941
2.17
8.05
7.1
3.8
34.81
35.34
g/l
0.54
132
869
89
506
2.19
7.56
2.9
2.1
3.82
3.42
mg/l
0.40
79
431
60
289
2.42
7.52
5.8
2.1
19.39
21.15
%
0.58
54
238
123
794
2.10
7.49
3.9
3.1
2.43
2.36
mmol/l
2.56
116
687
53
247
2.46
7.11
4.7
3.6
—
—
—
0
0
17
39
4.61
7.08
2.2
2.5
4.41
4.79
e9/l
0.20
17
39
162
1177
2.10
6.98
7.7
9.4
4.42
4.04
e9/l
1.26
147
1029
17
41
4.38
6.66
2.7
3.0
58.53
61.44
%
0.37
17
41
25
82
3.28
6.40
1.8
1.7
11.20
4.96
ug/l
0.26
20
74
122
831
1.93
5.98
4.9
2.5
193.63
118.87
ug/l
1.68
112
750
17
45
3.98
5.92
6.8
2.1
15.04
15.44
%
—
10
19
35
147
2.61
5.79
1.7
1.7
—
—
—
0
0
87
534
1.97
5.75
4.1
2.6
6127.93
11115.54
umol/l
0.36
76
446
98
634
1.91
5.50
4.6
3.7
29.73
7.52
mg/mmol
1.30
70
378
29
116
2.70
5.27
8.5
3.9
5.13
5.23
kpa
0.27
29
111
73
444
1.92
4.84
2.0
1.7
1311.40
1247.73
nmol/l
0.20
54
317
58
332
1.98
4.57
1.8
1.8
—
—
—
0
0
195
1637
1.92
4.19
10.6
7.2
83.02
79.32
u/l
0.54
190
1513
74
473
1.81
4.12
1.7
1.8
713.23
477.82
pmol/l
0.50
62
373
110
789
1.71
4.09
5.2
3.1
—
—
—
0
0
119
876
1.69
4.00
5.2
3.9
28.46
30.88
ng/l
0.17
100
647
7
8
8.96
3.79
3.6
6.3
—
—
—
0
0
98
694
1.68
3.75
2.4
2.0
106.77
197.31
u/l
2.30
93
645
138
1071
1.66
3.69
6.0
4.2
0.00
0.00
estimate
-0.00
44
226
89
618
1.69
3.65
4.6
3.0
0.16
0.49
e6/l
2.57
74
452
12
32
3.89
3.44
2.6
1.8
89.39
90.01
%
0.12
12
32
38
207
1.99
3.41
6.0
2.9
1.56
2.59
mmol/l
0.83
33
166
20
83
2.53
3.40
1.4
1.8
3.07
3.04
g/l
0.04
20
76
137
1081
1.60
3.27
7.2
5.6
0.00
0.00
estimate
-0.00
41
205
21
91
2.43
3.27
1.4
1.8
3.58
3.61
g/l
0.05
21
84
21
91
2.43
3.27
1.4
1.8
7.45
7.64
g/l
0.17
21
84
21
91
2.43
3.27
1.4
1.8
—
—
—
0
0
111
835
1.60
3.23
6.5
4.4
—
—
—
0
0
170
1418
1.64
3.19
6.3
4.9
—
4516.07
—
0
29
20
86
2.44
3.17
1.4
1.8
9.32
9.62
g/l
0.14
20
78
137
1087
1.59
3.15
6.0
4.2
0.00
0.01
estimate
0.50
40
202
186
1592
1.69
3.11
6.3
4.1
15.71
15.04
pmol/l
2.76
171
1418
58
375
1.72
3.03
1.4
1.3
19.82
43.10
iu/ml
2.33
24
130
91
663
1.59
2.98
2.7
2.2
58.52
63.88
u/l
0.26
85
603
37
211
1.89
2.91
6.2
2.9
5.54
5.79
kpa
0.65
37
206
9
23
4.02
2.80
1.2
1.3
—
—
—
0
0
9
23
4.02
2.80
1.2
1.3
—
—
—
0
0
84
608
1.58
2.80
7.2
4.5
0.00
0.00
estimate
-0.00
41
203
68
468
1.63
2.79
3.0
2.7
2.57
2.46
mmol/l
2.13
63
413
182
1569
1.61
2.75
6.1
4.3
15.96
13.62
mm/h
1.15
174
1412
211
1892
1.81
2.72
7.2
5.0
1.94
1.99
mu/l
0.21
197
1700
93
693
1.55
2.71
3.4
3.0
1824.58
1464.45
ng/l
0.36
81
588
68
472
1.61
2.68
1.8
1.6
2.24
1.13
mg/l
0.43
47
380
8
20
4.10
2.59
1.3
1.4
—
—
—
0
0
12
45
2.75
2.49
1.5
1.2
—
—
—
0
0
127
1031
1.48
2.39
2.5
2.6
—
—
—
0
0
10
33
3.11
2.38
1.7
1.3
—
—
—
0
0
113
897
1.48
2.37
2.2
2.0
105.01
100.17
pmol/l
0.32
53
411
7
18
3.97
2.27
1.1
1.1
—
—
—
0
0
9
29
3.18
2.25
1.2
1.4
—
—
—
0
0
6
14
4.36
2.16
1.7
1.3
—
—
—
0
0
38
242
1.67
2.09
1.7
1.7
—
—
—
0
0
5
10
5.08
2.08
1.0
1.4
4.76
9.27
u/l
—
5
10
38
243
1.67
2.06
1.7
1.8
—
—
—
0
0
6
15
4.07
2.05
1.0
1.1
—
—
—
0
0
72
539
1.47
1.97
1.6
1.5
20.51
22.58
nmol/l
0.50
66
441
8
27
3.03
1.95
2.6
1.4
—
—
—
0
0
5
11
4.61
1.95
1.6
2.4
3797.20
1020.45
u/ml
—
5
11
15
72
2.15
1.90
1.3
1.8
35.69
36.85
g/l
0.27
15
65
13
59
2.27
1.87
1.2
1.5
—
—
—
0
0
30
185
1.71
1.86
4.5
2.4
5.21
4.44
kpa
0.85
30
178
21
116
1.89
1.85
5.1
3.2
55.33
49.91
%
0.34
21
116
23
131
1.83
1.85
1.9
1.2
—
—
—
0
0
9
35
2.63
1.82
1.2
1.5
—
—
—
0
0
5
13
3.90
1.72
5.2
4.9
—
50.98
u/ml
—
0
5
57
418
1.47
1.72
4.4
3.7
53.34
139.70
ng/l
1.07
50
348
7
25
2.85
1.66
2.0
1.2
—
—
nmol/l
—
0
0
7
25
2.85
1.66
1.9
1.4
21.36
16.81
ug/l
—
7
25
20
113
1.84
1.66
4.3
3.0
22.89
25.06
mmol/l
1.07
20
113
28
176
1.67
1.63
5.4
3.1
42.41
58.33
ml/min/173m2
1.33
17
67
5
14
3.62
1.62
2.2
1.6
0.84
0.90
g/l
—
5
14
132
1132
1.36
1.58
6.1
5.7
9.50
10.53
umol/l
1.26
127
1062
14
71
2.03
1.57
1.1
1.2
—
—
—
0
0
208
1928
1.51
1.54
7.6
5.9
41.45
40.15
mmol/mol
1.06
192
1773
49
357
1.47
1.52
1.4
1.3
1.31
14.73
u/ml
2.94
17
129
217
2032
1.58
1.50
25.2
14.8
20.74
22.50
mg/l
0.48
191
1612
10
45
2.27
1.48
1.2
1.6
—
—
—
0
0
9
38
2.42
1.47
1.6
1.5
—
—
—
0
0
13
67
1.99
1.41
1.8
1.7
—
—
—
0
0
6
23
2.65
1.37
1.0
1.1
—
—
—
0
0
6
23
2.65
1.37
1.3
1.0
—
—
—
0
0
12
61
2.02
1.35
1.8
2.4
—
—
—
0
0
19
114
1.72
1.32
1.2
1.2
98.03
195.26
u/ml
0.91
19
101
6
24
2.54
1.31
1.0
1.5
—
—
—
0
0
5
18
2.81
1.29
3.6
2.4
—
—
—
0
0
6
25
2.43
1.25
1.0
1.1
—
—
—
0
0
11
56
2.01
1.24
1.6
1.4
—
1.75
—
0
11
11
57
1.97
1.19
1.6
1.4
—
8.55
—
0
14
16
95
1.73
1.17
1.0
1.0
—
—
—
0
0
58
459
1.34
1.13
2.9
2.2
—
—
—
0
0
8
41
1.98
1.10
1.3
1.3
—
—
—
0
0
48
372
1.36
1.07
3.0
2.6
1.56
1.01
e6/l
0.35
29
200
19
122
1.60
1.06
3.7
2.2
0.86
1.17
%
1.32
19
122
11
60
1.87
1.04
1.6
1.4
—
1.22
—
0
5
222
2121
1.48
1.02
29.4
18.0
107.53
74.95
umol/l
4.68
222
2121
9
48
1.91
1.01
1.2
1.5
—
—
—
0
0
106
924
1.26
0.99
3.0
2.5
—
—
—
0
0
203
1914
1.35
0.98
24.5
14.4
64.62
75.70
ml/min/173m2
7.64
192
1566
6
27
2.25
0.94
1.0
1.6
—
—
—
0
0
10
55
1.85
0.93
2.0
1.5
—
—
—
0
0
8
42
1.93
0.89
1.3
1.3
—
—
—
0
0
44
347
1.33
0.89
3.5
2.8
5.50
3.04
e6/l
0.54
26
178
28
205
1.41
0.88
3.8
2.1
5.82
7.98
umol/l
0.50
23
173
6
30
2.02
0.87
1.0
1.5
—
—
—
0
0
12
74
1.65
0.79
2.1
1.9
—
—
—
0
0
5
24
2.11
0.75
1.0
1.6
—
—
—
0
0
11
69
1.62
0.69
2.1
1.8
—
—
—
0
0
11
69
1.62
0.69
2.1
1.6
—
—
—
0
0
20
267
0.73
0.65
7.4
7.8
—
—
—
0
0
25
194
1.32
0.58
5.8
5.8
1.32
1.38
mmol/l
0.13
25
188
50
425
1.22
0.57
1.3
1.2
2.47
1.35
u/ml
0.27
15
111
6
36
1.68
0.57
1.8
1.1
32.67
14.99
u/l
—
6
31
16
117
1.39
0.54
1.1
1.4
—
42.73
—
0
8
6
40
1.51
0.52
2.5
1.1
—
—
—
0
0
7
46
1.54
0.48
1.1
1.1
33.57
5.20
e6/l
—
7
35
7
46
1.54
0.48
1.1
1.2
332.86
204.69
e6/l
—
7
36
7
48
1.47
0.47
1.0
1.3
—
—
—
0
0
8
118
0.67
0.47
2.4
1.8
—
—
—
0
0
220
2145
1.24
0.44
14.5
10.9
24.20
23.55
u/l
0.25
213
2052
5
31
1.63
0.43
2.2
1.6
—
—
—
0
0
0
16
0.00
0.41
0.0
1.9
—
—
—
0
0
0
17
0.00
0.41
0.0
1.0
—
—
—
0
0
0
17
0.00
0.41
0.0
1.1
—
1.07
—
0
12
0
17
0.00
0.41
0.0
1.8
—
—
—
0
0
16
124
1.31
0.40
1.9
1.6
—
—
—
0
0
9
67
1.36
0.38
1.3
1.7
—
—
—
0
0
6
42
1.44
0.36
2.2
1.6
—
—
—
0
0
6
42
1.44
0.36
2.7
2.5
107.67
105.81
mmol/l
—
6
42
224
2196
1.22
0.35
35.9
22.3
4.30
4.40
e12/l
2.10
219
2124
224
2196
1.22
0.35
35.9
22.3
38.91
39.43
%
0.61
211
2046
11
82
1.36
0.34
2.5
1.5
—
—
—
0
0
6
45
1.34
0.34
1.2
1.1
3.80
3.91
mmol/l
—
6
39
6
86
0.69
0.33
1.5
1.1
—
—
—
0
0
6
86
0.69
0.33
1.5
1.1
—
—
—
0
0
192
1969
0.89
0.29
5.3
4.7
1.49
1.56
mmol/l
1.14
172
1787
28
243
1.17
0.28
7.1
6.7
5.01
5.12
kpa
0.21
28
231
28
243
1.17
0.28
7.1
6.7
10.17
11.85
kpa
1.95
28
231
16
133
1.22
0.25
2.1
2.6
—
13.81
—
0
7
11
87
1.28
0.24
2.5
1.7
—
—
—
0
0
194
1981
0.90
0.23
5.3
4.7
4.59
4.71
mmol/l
0.82
175
1807
0
10
0.00
0.21
0.0
4.0
—
—
—
0
0
0
10
0.00
0.21
0.0
1.6
—
—
—
0
0
0
10
0.00
0.21
0.0
4.0
—
—
—
0
0
0
12
0.00
0.21
0.0
1.1
—
—
—
0
0
0
12
0.00
0.21
0.0
2.8
—
13.56
—
0
12
0
12
0.00
0.21
0.0
1.6
—
—
—
0
0
0
12
0.00
0.21
0.0
1.6
—
—
—
0
0
0
13
0.00
0.21
0.0
1.0
—
—
—
0
0
37
337
1.12
0.20
6.1
5.1
2.51
3.14
ug/l
0.24
29
296
204
2005
1.10
0.19
5.6
4.9
6.11
5.97
mmol/l
0.67
180
1806
127
1233
1.06
0.15
4.1
2.9
69.25
46.98
u/l
1.27
117
1135
25
274
0.90
0.14
5.4
4.4
24.07
21.49
%
0.34
15
139
24
262
0.91
0.13
4.9
4.7
36.18
33.65
%
0.43
17
168
29
313
0.92
0.13
1.3
1.4
—
—
—
0
0
206
2035
1.08
0.12
5.8
5.4
2.62
2.73
mmol/l
0.89
185
1839
5
47
1.07
0.09
1.0
1.4
—
—
—
0
0
5
47
1.07
0.09
1.0
1.4
—
—
—
0
0
60
582
1.04
0.07
1.6
1.6
1.49
1.29
mmol/l
0.94
43
468
189
1905
0.97
0.05
4.8
4.2
1.40
1.25
mmol/l
2.20
169
1722
26
269
0.96
0.02
1.5
1.4
—
—
—
0
0
48
488
0.98
0.01
7.6
4.5
1.01
1.02
kg/l
2.10
11
67
13
136
0.95
0.00
12.4
6.9
25.07
24.96
mmol/l
0.03
13
128
19
196
0.97
0.00
3.1
2.5
2.63
4.72
ug/l
2.79
19
172
12
119
1.01
0.00
1.3
1.2
130.96
137.07
iu/ml
—
7
52
10
104
0.96
0.00
1.3
1.3
—
—
—
0
0
20
195
1.03
0.00
9.0
7.3
116.60
119.67
g/l
0.23
20
189
6
62
0.97
0.00
1.7
1.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
2.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.7
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.7
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint E4_PARANAS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_PARANAS | 1.495 [1.3, 1.72] | < 0.001 |
| Birth year | 0.993 [0.98, 1.0] | 0.123 |
During the follow-up period (1.1.1998 — 31.12.2019), 411 out of 1112 females with E4_PARANAS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_PARANAS | 1.696 [1.3, 2.22] | < 0.001 |
| Birth year | 0.985 [0.98, 1.0] | 0.003 |
During the follow-up period (1.1.1998 — 31.12.2019), 129 out of 310 males with E4_PARANAS died.
Mortality risk
Mortality risk for people of age
years, who have E4_PARANAS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.142% | 0.283% |
| 5 | 0.791% | 1.52% |
| 10 | 2.046% | 4.214% |
| 15 | 4.067% | 8.631% |
| 20 | 7.273% | 14.569% |
Relationships between endpoints
↥Index endpoint: E4_PARANAS – Disorders of parathyroid gland, other and/or unspecified
GWS hits: 2
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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