No definition available.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519972 |
1. Apply sex-specific ruleNone |
519972 |
2. Check conditionsNone |
519972 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
3 out of 7 registries used, show all original rules. |
177 |
4. Check minimum number of eventsNone |
177 |
5. Include endpointsNone |
177 |
6. Filter based on genotype QC (FinnGen only) |
172 |
Control definitions (FinnGen only)
- Control exclude
- E4_METABOLIA
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- E83
- Name in latin
- Perturbationes metabolismi phosphori
Similar endpoints
↥List of similar endpoints to
Disorders of phosphorus metabolism and phosphatases
based on the number of shared cases.
Similar with more cases:
- Disorders of mineral metabolism
- Metabolic disorders
- Endocrine, nutritional and metabolic diseases
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 908 | 443 | 459 |
| Only index persons | 819 | 399 | 420 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.01 | 0.01 | 0.01 |
| Only index persons | 0.02 | 0.01 | 0.02 |
| Median age at first event (years) | |||
| Whole population | 54.06 | 52.80 | 55.17 |
| Only index persons | 54.59 | 53.52 | 55.61 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 172 | 91 | 81 |
| Unadjusted period prevalence (%) | 0.03 | 0.03 | 0.04 |
| Median age at first event (years) | 51.29 | 47.62 | 55.41 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 177
- Matched controls
- 1770
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
E83.39
ICD-10 Finland
Other disorder of phosphorus metabolism
+∞
187.4
145
*
123
Kela drug reimbursment
Chronic disorders of vitamin D metabolism
90.0
52.0
56
9
V03AG01
ATC
sodium cellulose phosphate; systemic
523.5
43.1
41
*
A11CC03
ATC
alfacalcidol; systemic
68.4
40.9
46
9
NK6QA
NOMESCO Finland
Measurement of bone density from two or more locations with X-ray
11.2
35.2
42
48
E87.6
ICD-10 Finland
Hypokalaemia
108.4
33.1
35
*
E83.3
ICD-10 Finland
Disorders of phosphorus metabolism and phosphatases
+∞
27.8
26
*
E83.30
ICD-10 Finland
Acid phosphatase deficiency
+∞
26.7
25
*
E83.4
ICD-10 Finland
Disorders of magnesium metabolism
+∞
25.6
24
*
A12AA04
ATC
calcium carbonate; oral
105.6
25.4
27
*
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
4.5
21.7
91
340
KH1AE
NOMESCO Finland
Urinary tract ultrasound examination
8.5
20.6
29
40
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
4.3
20.4
81
288
E83.51
ICD-10 Finland
Hypocalcemia
118.4
20.0
21
*
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
6.0
18.3
37
75
D64.9
ICD-10 Finland
Anaemia, unspecified
5.6
16.2
35
75
E83.50
ICD-10 Finland
Hypercalcemia
174.8
15.7
16
*
A49.9
ICD-10 Finland
Bacterial infection, unspecified
5.3
15.6
36
82
E87.1
ICD-10 Finland
Hypo-osmolality and hyponatraemia
39.8
14.7
18
5
AA1AD
NOMESCO Finland
CT of head and brain
3.7
14.2
62
227
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
4.1
13.9
46
139
N18.9
ICD-10 Finland
Chronic kidney disease, unspecified
14.5
13.9
23
18
JN3AD
NOMESCO Finland
Abdominal CT examination
4.6
13.0
35
90
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
4.1
12.7
42
126
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
5.0
12.5
30
70
TPH07
NOMESCO Finland
Cathetrisation of artery
4.7
12.5
32
79
H02AB09
ATC
hydrocortisone; systemic
15.3
11.2
18
13
ZX120
NOMESCO Finland
Intravenous
4.6
11.2
29
72
C03CA01
ATC
furosemide; systemic
3.2
11.1
56
221
F10.1
ICD-10 Finland
Mental and behavioural disorders due to use of alcohol, Harmful use
4.6
10.6
27
66
X59
ICD-10 Finland
Exposure to unspecified factor
3.2
10.5
52
202
2753A
ICD-9 Finland
Disorders of mineral metabolism, Disorders of phosphorus metabolism[HYPOPHOSPHATHAEMIA FAMILIARIS]
+∞
10.5
10
*
B05XA09
ATC
sodium phosphate; parenteral
+∞
10.5
10
*
SBB10
NOMESCO Finland
Dental impressions
3.9
10.3
34
101
M05BA04
ATC
alendronic acid; oral
5.3
10.3
22
46
N39.0
ICD-10 Finland
Urinary tract infection, site not specified
3.7
10.2
38
123
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
5.2
10.1
22
47
N17.9
ICD-10 Finland
Acute renal failure, unspecified
11.6
10.0
18
17
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
3.5
9.7
38
127
J18.9
ICD-10 Finland
Pneumonia, unspecified
3.1
9.6
52
212
L04AX01
ATC
azathioprine; systemic
8.5
9.4
20
26
K04.5
ICD-10 Finland
Chronic apical periodontitis
2.9
9.4
61
275
E86
ICD-10 Finland
Volume depletion
38.9
9.1
11
*
WX002
NOMESCO Finland
Sedation and analgesia
3.1
9.1
46
180
R56.8
ICD-10 Finland
Other and unspecified convulsions
5.1
9.1
20
43
WX408
NOMESCO Finland
General anesthesy, balanced
2.8
9.0
61
281
WZC00
NOMESCO Finland
Treatment plan or consultation
2.6
8.9
82
439
R4190
NOMESCO Finland
Nutritional therapy
4.8
8.9
21
48
H02AB06
ATC
prednisolone; systemic
2.5
8.5
93
537
NA2AA
NOMESCO Finland
Thoracal spine X-ray examination without contrast
13.7
8.5
14
11
WX892
NOMESCO Finland
Monitored bed care
4.6
8.5
21
50
E83.9
ICD-10 Finland
Disorder of mineral metabolism, unspecified
+∞
8.4
8
*
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.5
8.4
90
515
R50.9
ICD-10 Finland
Fever, unspecified
3.1
8.4
42
163
601
Kela drug reimbursment
Severe malabsorption of nutrients, mainly fats
15.5
8.3
13
9
SBB00
NOMESCO Finland
Clinical photography of mouth and teeth
6.9
8.3
20
32
SPA00
NOMESCO Finland
Changing form of teeth in prepation for prosthodontic work
7.9
8.2
18
25
SBB20
NOMESCO Finland
Tooth X-ray examination in conjunction with visit to dentist
23.3
8.1
11
5
ZXE10
NOMESCO Finland
More than one and less than three hours
2.5
8.1
77
415
R4110
NOMESCO Finland
Physiotherapy
2.6
8.1
64
316
WZC10
NOMESCO Finland
Written specialist consultation based on a referral from a dentist or a physician
7.6
8.0
18
26
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
3.6
7.9
28
87
E21.2
ICD-10 Finland
Other hyperparathyroidism
47.1
7.8
9
*
321
Kela drug reimbursment
Paricalcitol and cinacalcet
47.1
7.8
9
*
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
3.7
7.8
27
83
N02AA05
ATC
oxycodone; systemic
3.0
7.7
38
146
KA1AE
NOMESCO Finland
Kidney ultrasound examination
9.0
7.5
15
18
N06AX11
ATC
mirtazapine; oral
2.4
7.4
72
388
A12AA06
ATC
calcium lactate gluconate; oral
+∞
7.3
7
*
E83.8
ICD-10 Finland
Other disorders of mineral metabolism
+∞
7.3
7
*
K70.0
ICD-10 Finland
Alcoholic fatty liver
+∞
7.3
7
*
E55.9
ICD-10 Finland
Vitamin D deficiency, unspecified
31.4
7.2
9
*
J01EE01
ATC
sulfamethoxazole and trimethoprim; systemic
4.5
7.2
18
43
TPH04
NOMESCO Finland
Cathetrisation of vein
2.7
7.1
47
210
M05BX04
ATC
denosumab; parenteral
6.8
7.1
17
27
JN3AA
NOMESCO Finland
Abdominal X-ray examination without contrast
7.2
7.0
16
24
138
Kela drug reimbursment
Severe anaemia associated with chronic renal failure
14.5
7.0
11
8
Z71.3
ICD-10 Finland
Dietary counselling and surveillance
4.6
6.9
17
40
TPH90
NOMESCO Finland
Removal of fixed intravenous catheter
11.6
6.9
12
11
Z03.89
ICD-10 Finland
Observation for other suspected diseases and conditions
3.0
6.9
34
130
EB1JA
NOMESCO Finland
Double panorama tomography of teeth and jaws or similar X-ray examination
41.7
6.8
8
*
A03FA01
ATC
metoclopramide; systemic, rectal
2.6
6.8
47
215
I15.1
ICD-10 Finland
Hypertension secondary to other renal disorders
23.6
6.7
9
*
Z3226
NOMESCO Finland
Physiotherapist
2.7
6.7
44
196
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
2.3
6.7
87
528
UJF32
NOMESCO Finland
Coloscopy
2.5
6.7
53
259
R11
ICD-10 Finland
Nausea and vomiting
3.5
6.6
24
76
EBA15
NOMESCO Finland
Extraction of multiple teeth
6.4
6.5
16
27
EBB15
NOMESCO Finland
Insertion of dental implant abutment
72.3
6.5
7
*
A02BC02
ATC
pantoprazole; systemic
2.4
6.5
124
879
504
Kela drug reimbursment
Conditions requiring daily forced enteral nutrition
11.6
6.4
11
10
JN3BD
NOMESCO Finland
Extensive abdominal CT
3.2
6.4
27
94
N02AX02
ATC
tramadol; systemic, rectal
2.2
6.4
82
493
ZXE00
NOMESCO Finland
One hour or less
2.2
6.3
79
468
WW500
NOMESCO Finland
Blood transfusion
5.8
6.3
17
32
L04AD02
ATC
tacrolimus; systemic
18.9
6.3
9
5
UJF30
NOMESCO Finland
Ileoscopy through colon
3.4
6.3
24
78
26510
ICD-8 Finland
Vitamin D deficiency, Rickets, late effect
+∞
6.3
6
*
A11CC02
ATC
dihydrotachysterol; oral
+∞
6.3
6
*
E55.0
ICD-10 Finland
Rickets, active
+∞
6.3
6
*
E21.1
ICD-10 Finland
Secondary hyperparathyroidism, not elsewhere classified
+∞
6.3
6
*
B05DA
ATC
Isotonic solutions
27.8
6.3
8
*
R53
ICD-10 Finland
Malaise and fatigue
2.4
6.2
51
252
A28
ICPC
Limited function/disability NOS
2.9
6.2
32
125
127
Kela drug reimbursment
Transplant complication
13.1
6.2
10
8
WX882
NOMESCO Finland
High dependency care
6.5
6.1
15
25
Z03.3
ICD-10 Finland
Observation for suspected nervous system disorder
3.8
6.1
19
54
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
140
147
41.78
139.61
15.4
6.4
0.88
1.09
mmol/l
8.90
135
138
89
76
22.54
95.41
9.3
4.3
107.99
73.72
ng/l
1.55
82
68
157
644
13.73
40.25
23.0
6.6
1.21
1.22
mmol/l
0.10
135
554
109
424
5.09
25.60
4.6
3.0
2.33
2.36
mmol/l
0.82
103
386
64
166
5.47
24.62
5.5
2.3
21.68
24.10
%
0.62
56
146
56
131
5.79
24.15
11.0
6.7
1.78
1.77
mmol/l
0.00
49
108
64
174
5.19
23.15
5.8
2.2
2.18
2.40
g/l
1.57
58
163
68
196
5.01
22.89
5.8
2.2
12.58
14.29
umol/l
0.95
62
184
54
155
4.57
17.81
8.5
7.2
105.13
104.23
mmol/l
0.74
54
155
26
40
7.45
16.70
2.4
1.4
—
—
—
0
0
76
311
3.53
14.78
3.8
2.4
3.36
3.16
mg/l
0.18
68
272
78
330
3.44
14.30
4.5
2.9
3197.94
3686.24
umol/l
0.05
69
292
35
87
4.77
13.58
2.9
1.7
—
—
—
0
0
109
585
3.25
13.11
20.1
10.9
1.27
1.22
inr
0.26
35
176
137
844
3.76
13.07
18.2
10.2
4.05
3.86
e9/l
0.44
122
742
60
226
3.50
13.06
3.4
2.8
2.47
2.45
mmol/l
0.46
53
197
39
109
4.31
13.03
8.4
10.1
23.94
25.15
mmol/l
1.14
39
109
97
492
3.15
12.77
5.7
2.9
—
—
—
0
0
54
196
3.53
12.39
2.3
1.9
—
—
—
0
0
121
715
3.19
11.86
12.6
6.7
25.64
29.04
%
2.63
112
680
119
702
3.12
11.60
11.8
6.5
58.01
55.78
%
1.29
111
668
36
105
4.05
11.28
12.6
3.3
1.23
1.23
mmol/l
0.05
36
93
83
424
2.80
10.21
4.0
2.1
56.98
60.56
u/l
0.29
78
391
102
581
2.78
10.12
5.9
2.7
287.98
109.37
ug/l
1.50
94
534
119
735
2.89
10.07
14.4
6.1
11.61
11.38
umol/l
0.10
114
692
44
160
3.33
9.88
10.3
3.2
8.49
10.33
umol/l
0.22
37
137
18
18
10.99
9.78
4.6
1.4
4.72
4.76
kpa
0.06
18
18
34
108
3.66
9.37
8.4
4.2
2.66
1.85
mmol/l
0.74
26
87
48
190
3.09
9.32
3.3
3.1
29.82
29.80
s
0.01
48
185
61
277
2.83
9.24
2.4
2.1
1.50
0.88
mg/l
1.01
40
204
12
5
25.57
9.03
6.9
2.4
21.58
29.20
umol/l
—
12
5
21
32
7.30
8.98
1.6
1.3
242.99
304.07
ug/g
0.54
16
18
27
78
3.90
8.49
1.8
1.4
—
—
—
0
0
73
389
2.49
7.80
5.7
2.9
0.46
0.40
e6/l
0.09
65
303
87
505
2.42
7.67
3.3
1.9
97.96
96.29
pmol/l
0.13
58
267
36
134
3.12
7.66
7.5
6.5
0.20
0.90
mmol/l
0.58
31
111
36
134
3.12
7.66
7.4
6.5
4.96
5.15
kpa
0.50
36
129
36
134
3.12
7.66
7.4
6.4
12.81
12.42
kpa
0.15
36
129
25
75
3.72
7.43
2.4
1.7
—
—
—
0
0
42
175
2.84
7.31
4.0
2.1
2.05
1.46
%
1.94
31
156
18
43
4.55
7.20
2.2
1.8
—
—
—
0
0
18
31
6.34
7.14
3.6
3.4
55.57
42.44
mg/l
0.37
12
26
18
31
6.34
7.14
3.6
3.4
62.89
245.47
mg/l
0.43
12
25
20
53
4.13
7.03
1.7
1.8
—
256.00
—
0
5
36
141
2.95
6.99
2.3
1.8
—
—
—
0
0
102
653
2.33
6.98
3.5
2.5
—
—
—
0
0
36
142
2.93
6.90
2.2
1.8
—
—
—
0
0
14
18
8.34
6.76
4.1
2.2
18.02
16.88
%
—
9
10
64
342
2.36
6.61
3.1
2.3
—
—
—
0
0
47
220
2.55
6.46
3.7
2.9
2.79
1.67
e6/l
0.32
29
129
50
242
2.49
6.40
3.7
2.7
0.77
0.89
e6/l
0.11
32
151
17
43
4.27
6.33
1.9
1.6
—
—
—
0
0
142
1076
2.62
6.27
5.4
3.6
14.90
14.69
pmol/l
0.47
137
984
21
63
3.65
6.22
8.3
5.4
1.95
1.51
%
0.36
21
63
45
214
2.48
5.94
1.9
1.6
1631.71
1196.70
nmol/l
0.59
35
167
16
41
4.19
5.85
1.9
1.3
—
—
—
0
0
64
362
2.20
5.64
1.4
1.4
0.54
1.58
u/ml
0.96
13
87
10
10
10.51
5.60
3.6
2.6
80.30
140.50
ug/l
—
10
10
129
960
2.27
5.55
7.6
3.2
71.83
43.22
u/l
1.42
123
901
17
49
3.73
5.32
2.3
2.1
—
—
—
0
0
12
19
6.69
5.17
1.5
1.1
—
—
—
0
0
76
473
2.06
5.13
5.8
3.0
25.85
35.69
ng/l
0.70
66
301
19
61
3.37
5.08
8.9
5.5
0.67
0.67
%
0.02
19
61
27
107
2.80
5.08
3.2
2.6
51.63
72.34
ml/min/173m2
1.81
16
35
15
41
3.90
5.04
2.0
1.4
226.80
219.08
u/ml
—
10
24
30
127
2.64
4.98
6.2
2.7
—
—
—
0
0
14
29
5.15
4.93
4.1
2.2
23.86
25.74
mmol/l
0.66
14
29
14
30
4.97
4.80
1.4
1.1
—
—
—
0
0
14
30
4.97
4.80
1.4
1.1
—
—
—
0
0
15
43
3.72
4.73
1.6
1.5
—
—
—
0
0
(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection
7
5
14.49
4.61
1.0
1.0
—
—
—
0
0
13
27
5.11
4.60
3.1
1.7
—
—
—
0
0
156
1304
2.65
4.47
6.7
4.3
1.78
1.90
mu/l
0.66
150
1207
98
691
1.94
4.46
5.2
3.0
0.00
0.00
estimate
-0.00
28
139
12
24
5.28
4.40
5.5
2.7
5.90
4.28
e9/l
1.00
12
24
12
24
5.28
4.40
5.9
3.6
66.25
57.63
%
1.11
12
24
97
685
1.92
4.36
5.2
3.0
0.00
0.00
estimate
-0.00
28
147
8
9
9.24
4.32
1.3
1.0
2.01
1.78
mmol/l
—
8
9
10
17
6.16
4.19
3.6
1.5
2.21
1.55
mmol/l
—
10
17
96
686
1.87
4.06
6.5
4.0
0.00
0.00
estimate
-0.00
28
139
13
32
4.30
3.99
1.6
1.3
0.00
0.00
g/l
-0.00
13
32
13
32
4.30
3.99
1.6
1.3
0.00
0.00
g/l
-0.00
13
32
11
23
5.03
3.94
1.3
1.7
—
—
—
0
0
43
238
2.07
3.85
5.3
3.1
32.60
368.54
ng/l
1.85
32
171
15
50
3.19
3.79
4.5
4.4
85.67
94.12
%
0.58
15
50
20
79
2.73
3.78
7.0
7.2
95.11
93.16
%
0.90
20
79
13
34
4.04
3.78
1.6
1.4
0.00
0.00
g/l
-0.00
13
34
9
16
5.86
3.71
1.1
2.3
—
—
—
0
0
8
13
6.39
3.54
1.0
2.6
—
—
—
0
0
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
13
37
3.71
3.48
6.4
5.6
0.34
0.29
u/ml
—
8
23
54
337
1.87
3.39
3.8
2.8
3879.58
1081.83
ng/l
0.82
47
280
8
14
5.93
3.38
8.1
1.6
90.25
108.07
%
—
8
14
13
40
3.42
3.22
1.3
2.3
—
—
—
0
0
13
40
3.42
3.22
1.8
3.2
—
—
—
0
0
167
1499
3.02
3.13
45.5
13.1
139.02
139.95
mmol/l
4.30
167
1465
122
983
1.78
3.09
3.4
3.1
—
—
—
0
0
167
1501
2.99
3.08
46.4
13.2
3.95
3.95
mmol/l
0.01
167
1467
6
8
7.71
3.08
1.0
1.1
—
—
—
0
0
6
8
7.71
3.08
1.0
1.1
—
—
—
0
0
153
1326
2.13
3.06
31.5
10.9
81.89
84.51
ml/min/173m2
0.52
147
1078
13
47
2.91
2.88
3.2
1.4
—
—
—
0
0
5
6
8.53
2.76
1.0
1.3
—
—
—
0
0
9
24
3.89
2.71
3.0
2.2
3.72
6.02
u/ml
—
9
24
8
20
4.14
2.60
2.5
1.8
—
—
—
0
0
18
82
2.33
2.57
7.6
6.9
0.81
0.64
%
1.05
18
82
5
7
7.31
2.56
8.2
3.0
—
—
—
0
0
5
7
7.31
2.56
3.6
1.0
2253.20
1051.71
u/ml
—
5
7
10
31
3.36
2.56
1.3
1.2
—
—
—
0
0
7
16
4.51
2.50
1.1
1.2
—
—
—
0
0
55
376
1.67
2.44
6.4
3.2
0.00
0.00
estimate
-0.00
25
137
5
8
6.39
2.38
1.0
1.1
271.00
303.25
mg/l
—
5
8
7
17
4.24
2.38
1.0
1.0
—
—
—
0
0
169
1573
2.64
2.35
43.6
13.5
98.21
74.06
umol/l
2.58
169
1573
9
28
3.33
2.34
1.7
1.7
—
—
—
0
0
6
13
4.74
2.29
1.2
1.0
—
—
—
0
0
6
13
4.74
2.29
1.2
1.0
—
—
—
0
0
9
30
3.10
2.18
2.2
1.5
—
—
—
0
0
6
14
4.40
2.17
1.0
2.1
—
—
—
0
0
12
49
2.55
2.15
2.4
1.2
—
—
—
0
0
12
49
2.55
2.15
2.4
1.2
—
—
—
0
0
17
82
2.19
2.15
7.4
6.8
1.19
1.67
%
1.13
17
82
27
156
1.86
2.11
23.0
6.4
—
—
—
0
0
6
15
4.10
2.05
1.3
1.3
—
—
—
0
0
11
44
2.60
2.05
3.7
5.1
1.49
1.18
mmol/l
0.42
11
44
13
57
2.38
2.03
1.8
1.6
—
—
—
0
0
161
1471
2.05
2.03
38.6
12.0
26.61
22.66
mg/l
0.75
140
1103
7
21
3.43
1.98
1.1
2.1
—
—
—
0
0
7
22
3.27
1.90
1.3
2.2
—
—
—
0
0
7
22
3.27
1.90
1.3
2.2
—
—
—
0
0
8
28
2.94
1.88
1.3
2.0
—
—
—
0
0
8
28
2.94
1.88
4.4
1.2
—
—
—
0
0
8
28
2.94
1.88
1.3
2.0
—
—
—
0
0
6
17
3.61
1.85
1.2
1.2
—
—
—
0
0
5
12
4.25
1.83
3.0
1.3
3.14
3.83
mg/l
—
5
12
5
12
4.25
1.83
1.0
1.0
—
—
—
0
0
6
18
3.41
1.76
1.3
1.3
—
—
—
0
0
10
40
2.59
1.69
1.4
1.6
—
—
—
0
0
8
31
2.65
1.68
1.8
1.4
—
—
—
0
0
6
19
3.23
1.67
1.3
1.3
—
—
—
0
0
6
19
3.23
1.67
1.3
1.3
—
—
—
0
0
5
15
3.40
1.53
1.0
1.5
—
—
—
0
0
5
15
3.40
1.53
3.0
2.4
317.20
569.60
e6/l
—
5
15
6
21
2.92
1.52
2.0
1.1
—
—
—
0
0
6
21
2.92
1.52
1.0
1.0
—
—
—
0
0
145
1314
1.57
1.51
40.4
14.8
15.14
14.80
%
0.32
145
1291
5
16
3.18
1.45
1.4
1.9
—
—
—
0
0
5
16
3.18
1.45
1.4
1.9
—
—
—
0
0
5
16
3.18
1.45
1.2
2.1
2.16
4.11
nmol/l
—
5
16
5
17
2.99
1.37
1.0
1.1
—
—
—
0
0
34
239
1.52
1.31
1.3
1.3
0.91
11.76
u/ml
1.95
15
96
5
18
2.83
1.29
1.4
1.3
—
—
—
0
0
5
18
2.83
1.29
1.4
1.3
—
—
—
0
0
7
143
0.47
1.27
1.4
1.7
—
—
—
0
0
5
19
2.68
1.22
1.4
1.3
—
—
—
0
0
35
253
1.48
1.19
1.5
1.3
29.67
41.56
iu/ml
—
9
72
49
379
1.40
1.17
5.2
3.2
10.24
8.70
mg/mmol
0.15
29
226
65
536
1.34
1.03
5.9
3.0
—
—
—
0
0
7
35
2.04
1.01
1.9
1.2
—
—
—
0
0
5
23
2.21
0.98
1.0
1.3
—
—
—
0
0
7
36
1.98
0.98
1.9
1.2
—
—
—
0
0
25
177
1.48
0.95
2.6
2.5
—
—
—
0
0
6
31
1.97
0.85
1.3
1.2
—
—
—
0
0
22
158
1.45
0.79
2.5
2.4
—
—
—
0
0
6
34
1.79
0.77
1.3
1.6
—
—
—
0
0
5
25
2.03
0.73
1.4
1.6
—
—
—
0
0
37
297
1.31
0.70
2.0
1.6
—
—
—
0
0
13
86
1.55
0.68
2.5
1.4
—
—
—
0
0
137
1288
1.28
0.67
7.0
4.8
38.80
38.55
mmol/mol
0.09
132
1203
5
33
1.53
0.41
1.0
1.5
—
—
—
0
0
0
16
0.00
0.41
0.0
3.8
—
19.94
—
0
16
170
1669
1.47
0.41
54.9
17.9
38.85
40.62
%
3.29
165
1567
170
1667
1.50
0.41
54.6
17.8
256.76
250.23
e9/l
0.55
170
1628
0
18
0.00
0.40
0.0
1.6
—
—
—
0
0
141
1358
1.19
0.37
4.8
3.7
1.30
1.27
mmol/l
0.18
135
1255
146
1415
1.18
0.32
5.3
4.0
1.46
1.48
mmol/l
0.27
139
1309
170
1670
1.45
0.31
55.1
17.8
129.78
137.33
g/l
5.92
170
1648
170
1670
1.45
0.31
54.6
17.7
4.28
4.57
e12/l
6.53
170
1624
50
455
1.14
0.29
4.6
4.6
2.36
2.70
ug/l
0.15
43
407
146
1419
1.16
0.28
5.2
4.0
4.43
4.72
mmol/l
3.06
140
1321
11
87
1.28
0.25
1.6
2.2
—
—
—
0
0
34
377
0.88
0.24
4.8
4.2
22.90
21.19
%
0.20
13
181
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
0
13
0.00
0.21
0.0
1.2
—
214.75
—
0
13
6
48
1.26
0.20
1.5
1.5
—
269.87
—
0
24
142
1387
1.12
0.20
5.8
4.1
5.90
5.84
mmol/l
0.16
135
1284
25
278
0.88
0.18
3.0
2.9
0.80
0.72
ug/l
0.18
14
189
147
1444
1.11
0.15
5.6
4.5
2.54
2.82
mmol/l
3.00
141
1329
11
97
1.14
0.09
1.1
1.1
—
—
—
0
0
6
55
1.09
0.09
1.3
1.5
—
—
—
0
0
8
73
1.10
0.07
1.4
2.1
—
—
—
0
0
20
210
0.95
0.04
1.5
1.4
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
(3011547) Coagulation factor VII activity actual/normal in Platelet poor plasma by Coagulation assay
0
6
0.00
-0.00
0.0
1.0
—
127.33
—
0
6
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
(40770918) von Willebrand factor (vWf).activity actual/normal in Platelet poor plasma by Immunoassay
0
8
0.00
-0.00
0.0
2.4
—
145.88
—
0
8
0
7
0.00
-0.00
0.0
1.4
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint E4_PHOS_MET and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_PHOS_MET | 4.82 [3.0, 7.74] | < 0.001 |
| Birth year | 0.995 [0.99, 1.0] | 0.274 |
During the follow-up period (1.1.1998 — 31.12.2019), 78 out of 333 females with E4_PHOS_MET died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_PHOS_MET | 3.918 [2.62, 5.86] | < 0.001 |
| Birth year | 0.991 [0.98, 1.0] | 0.048 |
During the follow-up period (1.1.1998 — 31.12.2019), 99 out of 326 males with E4_PHOS_MET died.
Mortality risk
Mortality risk for people of age
years, who have E4_PHOS_MET.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.415% | 0.867% |
| 5 | 2.335% | 4.788% |
| 10 | 6.908% | 11.571% |
| 15 | 13.29% | 21.978% |
| 20 | 22.891% | 36.068% |
Relationships between endpoints
↥Index endpoint: E4_PHOS_MET – Disorders of phosphorus metabolism and phosphatases
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data