No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
3 out of 7 registries used, show all original rules. |
166 |
4. Check minimum number of eventsNone |
166 |
5. Include endpointsNone |
166 |
6. Filter based on genotype QC (FinnGen only) |
166 |
Control definitions (FinnGen only)
- Control exclude
- E4_METABOLIA
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- E83
- Name in latin
- Perturbationes metabolismi phosphori
Similar endpoints
↥List of similar endpoints to Disorders of phosphorus metabolism and phosphatases based on the number of shared cases.
Similar with more cases:
- Disorders of mineral metabolism
- Metabolic disorders
- Endocrine, nutritional and metabolic diseases
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥Summary Statistics
↥-FinRegistry-
Key figures
All | Female | Male | |
---|---|---|---|
Number of individuals | |||
Whole population | 908 | 443 | 459 |
Only index persons | 819 | 399 | 420 |
Unadjusted period prevalence (%) | |||
Whole population | 0.01 | 0.01 | 0.01 |
Only index persons | 0.02 | 0.01 | 0.02 |
Median age at first event (years) | |||
Whole population | 54.06 | 52.80 | 55.17 |
Only index persons | 54.59 | 53.52 | 55.61 |
-FinnGen-
Key figures
All | Female | Male | |
---|---|---|---|
Number of individuals | 166 | 90 | 76 |
Unadjusted period prevalence (%) | 0.03 | 0.03 | 0.03 |
Median age at first event (years) | 51.12 | 48.39 | 54.35 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 149
- Matched controls
- 1489
LabWAS
↥Mortality – FinRegistry
↥Association
Association between endpoint E4_PHOS_MET and mortality.
Females
Parameter | HR [95% CI] | p-value |
---|---|---|
E4_PHOS_MET | 4.82 [3.0, 7.74] | < 0.001 |
Birth year | 0.995 [0.99, 1.0] | 0.274 |
During the follow-up period (1.1.1998 — 31.12.2019), 78 out of 333 females with E4_PHOS_MET died.
Males
Parameter | HR [95% CI] | p-value |
---|---|---|
E4_PHOS_MET | 3.918 [2.62, 5.86] | < 0.001 |
Birth year | 0.991 [0.98, 1.0] | 0.048 |
During the follow-up period (1.1.1998 — 31.12.2019), 99 out of 326 males with E4_PHOS_MET died.
Mortality risk
Mortality risk for people of age
years, who have E4_PHOS_MET.N-year risk | Females | Males |
---|---|---|
1 | 0.415% | 0.867% |
5 | 2.335% | 4.788% |
10 | 6.908% | 11.571% |
15 | 13.29% | 21.978% |
20 | 22.891% | 36.068% |
Relationships between endpoints
↥Index endpoint: E4_PHOS_MET – Disorders of phosphorus metabolism and phosphatases
GWS hits: 1