Constitutional tall stature

E4_TALL

endocrine system disease: A disease involving the endocrine system.

Endpoint definition

↥

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — E34.40, E34.45 Cause of death: ICD-10 — E34.40, E34.45 2 out of 7 registries used, show all original rules.	200
4. Check minimum number of events None	200
5. Include endpoints None	200
6. Filter based on genotype QC (FinnGen only)	200

Control definitions (FinnGen only)

Control exclude: E4_ENDOGLAND

Extra metadata

Level in the ICD hierarchy: 4
First used in FinnGen datafreeze: DF2

NAME	E4_TALL
CONTROL_EXCLUDE	E4_ENDOGLAND
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	E344
HD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	E344
COD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Constitutional tall stature based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	200	133	67
Unadjusted period prevalence (%)	0.04	0.05	0.03
Median age at first event (years)	8.09	8.14	7.97

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
177: Matched controls
1770

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

E34.40

ICD-10 Finland

Constitutional tall stature

+∞

126.8

106

E34.45

ICD-10 Finland

Abnormal growth increase

+∞

98.3

NK6MA

NOMESCO Finland

Measurement of bone age from hand and elbow using X-ray

29.4

35.5

E34.35

ICD-10 Finland

Abnormal growth retardation

162.8

14.7

E30.1

ICD-10 Finland

Precocious puberty

+∞

9.5

E34.30

ICD-10 Finland

Short stature NOS

94.3

8.5

E27.0

ICD-10 Finland

Other adrenocortical overactivity

+∞

7.3

E34.4

ICD-10 Finland

Constitutional tall stature

+∞

7.3

R62.8

ICD-10 Finland

Other lack of expected normal physiological development

11.6

6.9

E22.80

ICD-10 Finland

Central precocious puberty

+∞

6.3

LabWAS

↥

(ID) Name

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3009214) Lutropin [Units/volume] in Serum or Plasma

103

5.04

17.51

2.7

1.6

4.7

6.2

u/l

0.91

(3023323) Follitropin [Units/volume] in Serum or Plasma

5.39

17.45

2.7

1.6

6.2

8.1

iu/l

0.34

(3017446) Testosterone [Moles/volume] in Serum or Plasma

5.34

16.15

2.2

1.7

6.5

12.0

nmol/l

2.36

(43534046) Estradiol (E2) [Moles/volume] in Serum or Plasma by High sensitivity method

8.35

12.48

2.1

1.3

0.0

0.2

nmol/l

1.55

(3008486) Thyroxine (T4) free [Moles/volume] in Serum or Plasma

154

1174

2.36

6.17

3.5

14.5

14.4

pmol/l

0.22

143

1058

(3009201) Thyrotropin [Units/volume] in Serum or Plasma

167

1339

2.50

5.63

3.9

4.0

1.9

mu/l

0.11

162

1258

(40758558) Short blood count panel - Blood

443

1.85

3.93

4.3

8.0

—

(3035637) Corticotropin [Mass/volume] in Plasma

3.37

3.10

1.6

1.7

—

(3015377) Calcium [Moles/volume] in Serum or Plasma

305

1.80

3.00

1.6

2.2

2.4

mmol/l

0.22

275

(3020059) Calcium [Moles/volume] corrected for albumin in Serum or Plasma

116

2.11

2.58

1.7

2.4

mmol/l

0.34

(3003031) Transferrin.carbohydrate deficient.disialo/Transferrin.total in Serum or Plasma

231

1.74

2.23

1.5

1.6

1.4

0.12

213

(3019225) pH of Specimen

2.30

2.17

3.3

5.1

—

(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma

590

1.50

1.98

3.6

9.9

1.2

mmol/l

0.05

535

(42868674) Cholesterol in HDL/Cholesterol.total [Molar ratio] in Serum or Plasma

2.07

1.91

2.1

1.9

29.3

31.9

0.59

(3006418) Campylobacter sp identified in Tissue by Organism specific culture

2.64

1.82

1.0

1.1

—

(36660697) Celiac disease serology panel - Serum

254

1.61

1.78

1.3

1.2

—

(42529406) Shigella sp [Presence] in Stool by Culture

2.57

1.76

1.0

1.2

—

(3014765) Yersinia sp identified in Stool by Organism specific culture

2.57

1.76

1.0

1.2

—

(3021584) Pregnancy associated plasma protein A [Units/volume] in Serum or Plasma

312

0.57

1.55

1.6

1.4

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

505

0.65

1.54

1.9

3.0

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

587

0.68

1.46

1.6

1.7

—

(3029937) Albumin [Presence] in Urine by Test strip

364

0.61

1.44

2.0

3.2

0.0

estimate

—

148

(3025941) Bacteria identified in Stool by Culture

2.01

1.42

1.1

—

(3020321) Streptococcus agalactiae [Presence] in Vaginal fluid by Organism specific culture

146

0.46

1.38

1.4

1.6

—

(4198724)

2.66

1.38

1.3

2.5

—

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

314

1.47

1.36

1.6

1.4

93.3

95.2

pmol/l

0.07

158

(36032269) Testosterone Free [Moles/volume] in Serum or Plasma by calculation

2.82

1.29

1.0

1.4

99.4

217.3

pmol/l

—

(3028772) Osteocalcin [Mass/volume] in Serum or Plasma

2.82

1.29

3.2

2.4

—

(3003191) Choriogonadotropin (pregnancy test) [Presence] in Serum or Plasma

189

1.56

1.27

1.6

1.8

—

(21492888) Glucose tolerance 2 hours gestational panel - Serum or Plasma

144

0.47

1.26

1.4

1.7

—

(40760892) CBC W Ordered Manual Differential panel - Blood

352

0.64

1.25

2.4

4.5

—

(3018171) Choriogonadotropin [Units/volume] in Serum or Plasma

243

0.59

1.18

3.3

2.4

5911.5

4759.5

u/l

—

100

(43534045) MCM6 gene c.-13910C>T and -13915T>G [Identifier] in Blood or Tissue by Molecular genetics method Nominal

193

1.52

1.17

1.0

1.1

—

(3000570) Elastase.pancreatic [Mass/mass] in Stool

2.54

1.16

1.0

1.4

452.4

422.5

ug/g

—

(3021601) Nitrite [Presence] in Urine by Test strip

711

0.74

1.12

3.3

4.5

0.0

estimate

—

150

(3009261) Glucose [Presence] in Urine by Test strip

719

0.75

1.09

2.2

3.2

0.0

estimate

—

146

(3023602) Cholesterol in HDL [Moles/volume] in Serum or Plasma

114

1011

1.30

1.02

2.4

1.4

mmol/l

1.05

109

956

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

784

1.29

1.01

2.0

1.9

—

(3019832) Treponema pallidum Ab [Presence] in Serum

544

0.73

1.01

1.8

—

(3002523) Influenza virus A Ag [Presence] in Specimen

1.85

1.00

1.0

1.1

—

(3003740) Influenza virus B Ag [Presence] in Specimen

1.85

1.00

1.0

1.1

—

(3041096) Erythrocytes [Presence] in Urine by Automated

390

0.70

0.98

2.0

2.7

—

(3024928) Oxygen saturation in Venous blood

0.00

0.98

0.0

26.3

—

(3007449) CD3+CD8+ (T8 suppressor) cells/100 cells in Blood

0.00

0.98

0.0

2.6

—

25.3

—

(3048689) Calprotectin [Mass/mass] in Stool

316

1.37

0.98

2.0

3.1

105.3

76.0

ug/g

0.34

243

(3014111) Lactate [Moles/volume] in Serum or Plasma

116

0.50

0.97

2.3

15.1

2.6

1.3

mmol/l

—

108

(3000060) B lymphocytes [#/volume] in Blood

0.00

0.97

0.0

2.5

—

421.9

—

(3005757) Coagulation factor V activity actual/normal in Platelet poor plasma by Coagulation assay

0.00

0.97

0.0

5.4

—

94.7

—

(21493690) Lymphocyte T-cell and B-cell and Natural killer subsets panel - Blood

0.00

0.97

0.0

2.9

—

(3006245) CD3-CD19+ cells/100 cells in Blood

0.00

0.96

0.0

2.7

—

19.9

—

(3050129) First trimester maternal screen panel - Serum or Plasma

193

0.60

0.93

1.5

1.4

—

(1002102) Choriogonadotropin.intact+Beta subunit [Mass/volume] in Serum or Plasma

126

0.54

0.92

1.1

1.5

—

(3044491) Cholesterol non HDL [Mass/volume] in Serum or Plasma

113

0.52

0.86

1.0

1.2

—

(3035350) Ketones [Presence] in Urine by Test strip

710

0.78

0.85

2.1

3.1

0.0

estimate

—

144

(3044254) Respiratory syncytial virus RNA [Presence] in Specimen by NAA with probe detection

1.77

0.83

1.6

2.1

—

(3025130) Human papilloma virus identified in Specimen

1.90

0.82

1.8

—

(3043238) Trisomy 21 risk [Likelihood] in Fetus

122

0.56

0.81

1.7

1.4

—

(3021879) Hepatitis B virus core Ab [Presence] in Serum

197

0.64

0.80

1.2

1.5

—

(3016293) Bicarbonate [Moles/volume] in Serum or Plasma

255

1.35

0.78

2.6

12.5

23.8

24.6

mmol/l

0.88

255

(3026008) Bacteria identified in Urine by Culture

397

0.74

0.78

1.7

2.4

—

(3016018) Differential panel - Cerebral spinal fluid

0.00

0.76

0.0

5.2

—

(40768443) Skin Pathology biopsy report

1.87

0.74

1.1

—

(3032080) INR in Blood by Coagulation assay

305

0.72

0.73

2.9

4.2

1.1

inr

—

107

(3019900) Cholesterol [Moles/volume] in Serum or Plasma

113

1028

1.23

0.71

2.5

4.4

mmol/l

0.01

108

979

(36032419) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Immunoassay

116

0.59

0.70

1.7

2.2

—

(3022145) Colonoscopy Study observation

1.59

0.70

1.7

1.5

—

(3047352) Trisomy 18 risk [Likelihood] in Fetus

119

0.57

0.70

1.4

1.3

—

(3005033) Fetal Nuchal fold Thickness US

119

0.57

0.70

1.4

1.3

—

(3018418) pH of Serum or Plasma

251

1.33

0.70

1.8

3.4

7.4

—

(3024891) Influenza virus A+B Ag [Presence] in Specimen

1.63

0.70

1.2

—

(3000494) Fungus identified in Specimen by Culture

119

1.47

0.69

1.4

1.6

—

(3018251) Fasting glucose [Moles/volume] in Serum or Plasma

113

1031

1.22

0.68

2.7

2.1

5.2

5.3

mmol/l

1.36

105

930

(3007461) Platelets [#/volume] in Blood

189

1834

1.56

0.68

10.6

13.7

272.7

267.3

e9/l

0.67

183

1759

(3019050) Tissue transglutaminase IgA Ab [Units/volume] in Serum

638

1.23

0.67

1.8

1.6

2.0

3.6

u/ml

0.54

135

(3002148) Methylenedioxymethamphetamine [Presence] in Urine by Screen method

1.65

0.67

1.1

1.7

—

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

222

0.70

0.66

1.9

2.1

12.3

13.5

ng/l

—

(3015736) pH of Urine

565

0.80

0.63

2.0

3.0

—

(3000924) Streptococcus pyogenes [Presence] in Throat by Organism specific culture

113

1.45

0.63

1.5

1.3

—

(3024731) MCV [Entitic volume]

189

1837

1.52

0.63

10.5

13.6

86.8

87.3

0.75

189

1813

(3021589) Normoblasts [#/volume] in Blood

828

1.21

0.63

5.3

9.4

0.0

e9/l

0.48

639

(3013826) Glucose [Moles/volume] in Serum or Plasma

779

1.21

0.62

2.7

6.6

6.0

5.9

mmol/l

0.09

697

(3026361) Erythrocytes [#/volume] in Blood

189

1838

1.51

0.61

10.5

13.6

4.7

4.6

e12/l

2.49

183

1762

(3035941) MCH [Entitic mass]

189

1838

1.51

0.61

10.5

13.6

29.0

29.3

1.48

189

1813

(40770918) von Willebrand factor (vWf).activity actual/normal in Platelet poor plasma by Immunoassay

0.00

0.60

0.0

1.2

—

127.4

—

(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)

112

1029

1.20

0.60

5.4

5.7

109.1

110.6

ml/min/173m2

0.34

721

(3005136) Cladosporium herbarum IgE Ab [Units/volume] in Serum

1.56

0.60

1.1

4.2

0.8

u/ml

—

(3046896) Herpes virus 6 DNA [Presence] in Cerebral spinal fluid by NAA with probe detection

0.00

0.60

0.0

1.0

—

(3028026) IgM [Mass/volume] in Serum or Plasma

111

0.62

0.60

1.3

1.8

1.0

g/l

—

102

(40768797) Stomach Pathology biopsy report

111

0.62

0.60

1.0

1.2

—

(3001122) Ferritin [Mass/volume] in Serum or Plasma

849

0.83

0.59

2.6

2.8

50.9

49.2

ug/l

0.08

794

(3011288) Drugs identified in Urine by Screen method

176

1.35

0.59

2.0

2.6

—

(3011648) Oxygen content in Venous blood

0.00

0.59

0.0

31.2

—

11.2

—

(3003265) Liver kidney microsomal Ab [Titer] in Serum by Immunofluorescence

0.00

0.59

0.0

2.1

—

(3003694) ABO and Rh group [Type] in Blood

644

0.82

0.59

1.7

1.8

—

(3049207) Fetal Trisomy 21 risk [Likelihood] Based on maternal age

149

0.65

0.59

1.5

1.3

—

(3013139) Helicobacter pylori Ag [Presence] in Stool

1.51

0.58

1.5

1.1

—

(46237023) Hepatitis B virus core and surface Ab and surface Ag panel - Serum

0.57

1.2

1.4

—

(40763531) Fetal Nuchal fold [Multiple of the median] Thickness adjusted for maternal weight

148

0.66

0.57

1.5

1.3

—

(3008714) Choriogonadotropin [Multiple of the median] adjusted in Serum or Plasma

148

0.66

0.57

1.5

1.3

—

(46235831) Pregnancy associated plasma protein A [Multiple of the median] adjusted in Serum or Plasma

148

0.66

0.57

1.5

1.3

—

(3000963) Hemoglobin [Mass/volume] in Blood

189

1841

1.48

0.57

10.6

13.9

135.3

133.9

g/l

0.78

189

1815

(3010813) Leukocytes [#/volume] in Blood

189

1841

1.48

0.57

10.5

13.6

6.7

7.0

e9/l

0.97

183

1761

(1175715) Chlamydophila pneumoniae IgM Ab [Presence] in Serum by Immunoassay

1.47

0.57

1.0

1.2

—

(3048773) Triglyceride [Moles/volume] in Serum or Plasma --fasting

104

954

1.19

0.56

2.2

2.3

1.2

1.1

mmol/l

0.39

908

(40771025) 25-Hydroxyvitamin D3+25-Hydroxyvitamin D2 [Moles/volume] in Serum or Plasma

543

1.21

0.55

2.0

2.8

61.6

67.4

nmol/l

1.16

502

(3000855) Microscopic observation [Identifier] in Vaginal fluid by Gram stain

1.52

0.55

1.7

1.4

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

332

0.78

0.52

1.6

—

(3046524) Influenza virus A Ag [Presence] in Nasopharynx by Immunoassay

1.52

0.52

1.2

1.3

—

(3043362) Influenza virus B Ag [Presence] in Nasopharynx by Immunoassay

1.52

0.52

1.2

1.3

—

(3024561) Albumin [Mass/volume] in Serum or Plasma

403

1.22

0.52

2.4

6.8

39.2

37.9

g/l

0.99

383

(3001019) Free T4 and TSH panel - Serum or Plasma

1.49

0.52

1.2

1.5

—

(3003338) MCHC [Mass/volume]

163

1564

1.23

0.49

9.3

12.3

333.4

334.7

g/l

1.09

163

1547

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

644

0.84

0.49

3.6

4.4

—

(3041806) Other cells [#/volume] in Blood by Manual count

1.54

0.49

1.3

1.7

—

(42870588) Differential panel, method unspecified - Blood

608

1.18

0.48

5.3

8.7

—

(46235759) Influenza virus B RNA [Presence] in Nasopharynx by NAA with probe detection

1.47

0.47

1.7

2.0

—

(3004716) Salmonella sp identified in Stool by Organism specific culture

165

1.30

0.47

1.1

1.2

—

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

151

0.71

0.44

1.2

2.2

—

(3005719) IgG [Mass/volume] in Serum or Plasma

139

0.70

0.43

1.9

2.7

9.3

9.0

g/l

—

129

(3007164) IgA [Mass/volume] in Serum or Plasma

576

1.16

0.41

1.5

1.9

1.7

g/l

0.68

310

(3010375) cycloSPORINE [Mass/volume] in Blood

0.00

0.41

0.0

42.7

—

189.7

—

(3036035) von Willebrand factor (vWf) Ag actual/normal in Platelet poor plasma by Immunoassay

0.00

0.41

0.0

1.1

—

128.9

—

(3005353) Prothrombin activity actual/normal in Platelet poor plasma by Coagulation assay

0.00

0.41

0.0

1.0

—

93.1

—

(3042733) HLA Ab [Presence] in Serum

0.00

0.41

0.0

3.2

—

(3012477) Bordetella pertussis DNA [Presence] in Specimen by NAA with probe detection

0.00

0.41

0.0

1.6

—

(3029396) Erythrocyte agglutination [Presence] in Blood

0.00

0.41

0.0

3.3

—

(3022229) Phosphate [Moles/volume] in Urine

0.00

0.41

0.0

3.4

—

18.0

—

(3000208) Alpha tocopherol [Moles/volume] in Serum or Plasma

0.00

0.41

0.0

4.3

—

23.4

—

(4027681)

0.00

0.41

0.0

1.4

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

737

0.86

0.41

2.2

—

(3045142) Bone marrow Pathology biopsy report

0.00

0.41

0.0

1.9

—

(3018738) Hemoglobin F/Hemoglobin.total in Blood

0.00

0.41

0.0

3.5

—

0.3

—

(3053028) Streptococcus sp identified in Specimen by Organism specific culture

0.00

0.41

0.0

1.4

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

343

0.82

0.41

1.7

2.6

—

(3023368) Bacteria identified in Blood by Culture

236

0.78

0.40

2.2

3.6

—

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

634

0.86

0.40

2.6

2.4

—

(40758990) Choriogonadotropin.beta subunit [Mass/volume] in Serum or Plasma

0.00

0.40

0.0

1.2

—

(3016038) Potassium [Moles/volume] in Urine

0.00

0.40

0.0

2.3

—

34.9

—

(3024932) HLA-DR beta [Type]

0.00

0.40

0.0

1.2

—

(3024471) HLA-A [Type]

0.00

0.40

0.0

1.0

—

(3001684) Respiratory syncytial virus Ag [Presence] in Specimen

1.44

0.39

1.2

1.1

—

(3025018) Bordetella pertussis Ab [Titer] in Serum

1.40

0.38

1.0

1.3

—

(3013115) Eosinophils [#/volume] in Blood

886

1.14

0.37

5.6

8.4

0.2

e9/l

0.24

762

(3009542) Hematocrit [Volume Fraction] of Blood

169

1640

1.20

0.36

8.9

11.7

40.4

39.7

1.56

158

1445

(3002030) Lymphocytes/100 leukocytes in Blood

909

1.13

0.34

5.2

7.7

35.2

34.2

0.35

875

(3019145) Choriogonadotropin.beta subunit free [Mass/volume] in Serum or Plasma

176

0.78

0.33

1.7

1.4

—

(3013512) EKG study

183

1.23

0.33

2.0

2.2

—

(3018010) Neutrophils/100 leukocytes in Blood

892

1.12

0.32

5.3

7.5

50.5

51.6

0.32

860

(3024354) Oxygen [Partial pressure] in Venous blood

228

0.82

0.31

1.5

10.0

5.2

kpa

0.03

222

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

332

0.85

0.30

1.4

1.5

—

(3002256) Pathology report gross observation

108

0.73

0.30

1.0

1.1

—

(3021447) Carbon dioxide [Partial pressure] in Venous blood

237

0.83

0.29

1.7

9.9

5.6

5.8

kpa

0.22

229

(3022313) Gas panel - Capillary blood

215

1.19

0.28

2.6

7.7

—

(3006093) Chlamydia trachomatis DNA [Presence] in Specimen by NAA with probe detection

444

0.88

0.27

1.8

2.1

—

(3002032) Base excess in Venous blood by calculation

235

0.83

0.27

1.7

10.0

0.7

1.1

mmol/l

0.13

173

(3013650) Neutrophils [#/volume] in Blood by Automated count

102

969

1.11

0.27

7.0

9.2

3.8

3.7

e9/l

0.11

815

(3037467) Urinalysis macro (dipstick) panel - Urine

1021

0.90

0.27

3.4

3.9

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

188

1.19

0.27

1.3

1.9

—

(3015635) Cytomegalovirus IgM Ab [Units/volume] in Serum or Plasma

0.70

0.26

1.0

1.8

—

(3017918) Cytomegalovirus IgG Ab [Titer] in Serum or Plasma

0.69

0.26

1.0

1.8

—

(3044889) 12 lead EKG panel

623

1.11

0.26

2.1

2.0

—

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

0.68

0.26

1.2

2.1

—

(1002224) Polysomnography panel

1.36

0.23

1.0

1.2

—

(3000991) Gas panel - Venous blood

209

0.85

0.22

2.0

10.9

—

(3026493) Urate [Moles/volume] in Serum or Plasma

173

1.17

0.22

2.0

4.9

359.6

4874.0

umol/l

0.78

161

(3044640) Blood type and Crossmatch panel - Blood

416

0.89

0.21

1.8

2.8

—

(3028286) Albumin [Mass/volume] in Serum or Plasma by Electrophoresis

0.00

0.21

0.0

1.0

—

41.7

—

(3020565) Legionella pneumophila DNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

1.7

—

(3015183) Erythrocyte sedimentation rate

0.00

0.21

0.0

1.1

—

(3023465) Gamma globulin [Mass/volume] in Serum or Plasma by Electrophoresis

0.00

0.21

0.0

1.0

—

10.0

—

(3029379) Protein.monoclonal band 4 [Mass/volume] in Serum or Plasma by Electrophoresis

0.00

0.21

0.0

1.0

—

0.0

—

(3041642) Human coronavirus 229E RNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

1.5

—

(3008037) Lactate [Moles/volume] in Venous blood

0.00

0.21

0.0

1.5

—

1.1

—

(3029338) Protein.monoclonal band 3 [Mass/volume] in Serum or Plasma by Electrophoresis

0.00

0.21

0.0

1.0

—

0.0

—

(3001964) Herpes simplex virus Ag [Presence] in Specimen

0.00

0.21

0.0

2.6

—

(3014162) Mycobacterium tuberculosis DNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

1.6

—

(3038546) Human coronavirus OC43 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

1.5

—

(3040359) Human coronavirus NL63 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

1.5

—

(21494755) Public health laboratory ask at order entry panel

166

0.83

0.21

1.3

1.2

—

(3043723) Beta 1 globulin [Mass/volume] in Serum or Plasma by Electrophoresis

0.00

0.21

0.0

1.0

—

(3029713) Protein.monoclonal band 1 [Mass/volume] in Serum or Plasma by Electrophoresis

0.00

0.21

0.0

1.0

—

0.0

—

(3021952) Alkaline phosphatase isoenzymes [Enzymatic activity/volume] in Serum or Plasma by Heat stability

0.00

0.21

0.0

1.1

—

(3035797) Protein.monoclonal band 2 [Mass/volume] in Serum or Plasma by Electrophoresis

0.00

0.21

0.0

1.0

—

0.0

—

(3031478) Chlamydophila pneumoniae DNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

1.1

—

(40769539) Bacteria identified based on 16S rRNA gene [Identifier] in Specimen by Sequencing

0.00

0.21

0.0

1.2

—

(3000504) BK virus DNA [Units/volume] (viral load) in Serum or Plasma by NAA with probe detection

0.00

0.21

0.0

5.9

—

(3006504) Eosinophils/100 leukocytes in Blood

838

1.09

0.21

5.6

8.0

3.1

0.02

797

(3000330) Specific gravity of Urine by Test strip

1.17

0.21

1.8

1.9

—

(3003327) Ova and parasites identified in Stool by Light microscopy

1.26

0.21

1.2

1.5

—

(3028334) Neisseria gonorrhoeae [Presence] in Specimen by Organism specific culture

0.00

0.21

0.0

1.2

—

(40758897) Direct antiglobulin test.IgG specific reagent [Presence] on Red Blood Cells

0.00

0.21

0.0

3.8

—

(3040363) Hepatitis A virus IgG Ab [Presence] in Serum by Immunoassay

0.00

0.21

0.0

1.1

—

(21494434) Karyotype in Bone marrow

0.00

0.21

0.0

1.6

—

(40758895) Direct antiglobulin test.complement C3d specific reagent [Presence] on Red Blood Cells

0.00

0.21

0.0

3.8

—

(3036071) Salmonella sp Ab [Titer] in Serum

0.00

0.21

0.0

1.2

—

(3007853) Bacteria identified in Skin by Aerobe culture

197

0.85

0.20

1.8

1.4

—

(40757494) Bilirubin.total [Moles/volume] in Blood

0.00

0.20

0.0

9.5

—

168.4

—

(3004409) Coagulation factor X activity actual/normal in Platelet poor plasma by Coagulation assay

0.00

0.20

0.0

1.0

—

89.1

—

(3011547) Coagulation factor VII activity actual/normal in Platelet poor plasma by Coagulation assay

0.00

0.20

0.0

1.0

—

119.5

—

(3048518) aPTT.lupus sensitive actual/normal (normalized LA screen)

0.00

0.20

0.0

1.0

—

1.0

—

(3012447) Hantavirus puumala IgG Ab [Titer] in Serum

0.00

0.20

0.0

1.0

—

(3047007) Chlamydophila sp Ab [Presence] in Serum

1.23

0.20

1.0

1.2

—

(3042975) Streptococcus sp identified in Isolate by Organism specific culture

1.21

0.20

1.3

1.2

—

(3011397) Hemoglobin [Presence] in Urine by Test strip

362

0.89

0.19

1.9

3.1

—

(40761536) Microorganisms panel - Urine sediment

132

0.82

0.19

2.5

3.6

—

(3022096) Basophils/100 leukocytes in Blood

812

1.08

0.18

5.7

8.2

0.6

0.31

778

(1001926) Buprenorphine [Presence] in Urine by Screen method

195

1.14

0.18

1.5

2.2

—

(3004789) Transferrin [Mass/volume] in Serum or Plasma

142

0.84

0.18

2.3

2.9

2.6

2.5

g/l

0.18

132

(3001604) Monocytes [#/volume] in Blood

863

1.08

0.18

5.5

7.8

0.6

0.5

e9/l

1.49

728

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

1.15

0.17

1.3

1.8

—

(3009035) Cobalamin (Vitamin B12) [Moles/volume] in Serum or Plasma

129

1.18

0.17

1.3

1.4

365.8

59292470.9

pmol/l

—

113

(3019069) Monocytes/100 leukocytes in Blood

844

1.08

0.17

5.6

8.1

0.04

811

(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection

0.73

0.17

1.6

1.5

—

(3006315) Basophils [#/volume] in Blood

864

1.08

0.17

5.5

7.8

0.0

e9/l

0.29

727

(3035995) Alkaline phosphatase [Enzymatic activity/volume] in Serum or Plasma

836

1.07

0.16

4.0

4.9

95.0

99.0

u/l

0.17

773

(3022621) pH of Urine by Test strip

0.78

0.16

2.2

2.0

—

(3042206) Streptococcus agalactiae Ag [Presence] in Vaginal fluid

0.74

0.15

1.2

—

(3008401) Mugwort IgE Ab [Units/volume] in Serum

121

1.17

0.15

1.1

1.2

0.4

1.1

u/ml

—

(3019250) Coagulation factor VIII activity actual/normal in Platelet poor plasma by Coagulation assay

0.80

0.15

1.3

7.4

129.6

161.9

—

(3010726) Horse dander IgE Ab [Units/volume] in Serum

122

1.16

0.14

1.1

1.2

5.6

5.1

u/ml

—

(3008898) HLA-B27 [Presence]

0.80

0.14

1.0

—

(3018095) Leukocytes [#/volume] in Urine

568

0.93

0.13

2.9

4.1

37.5

73.4

e6/l

0.64

351

(3048929) Epstein Barr virus Ab [Presence] in Serum

190

0.88

0.13

1.2

1.6

—

(3019198) Lymphocytes [#/volume] in Blood

920

1.06

0.13

5.3

7.6

2.4

2.3

e9/l

0.53

802

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

133

1.14

0.12

1.3

1.9

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

167

1692

0.92

0.12

4.1

—

(40763571) Iron/Transferrin [Ratio] in Serum or Plasma

126

0.87

0.11

2.5

3.1

22.4

24.7

0.29

117

(3000492) Spirometry study

126

0.87

0.11

1.4

1.3

—

(3042936) Bacteria identified in Isolate by Culture

134

1.13

0.11

1.5

—

(43055554) Base excess.100% oxygenated [Moles/volume] standard in Capillary blood by calculation

241

1.09

0.11

3.0

7.9

-0.6

1.0

mmol/l

1.07

179

(3023024) Carbon dioxide [Partial pressure] in Capillary blood

242

1.09

0.10

3.0

7.9

4.8

5.0

kpa

1.47

231

(36304419) Bacteria [Presence] in Urine

421

0.94

0.10

2.6

3.5

—

(44816844) Macroprolactin [Units/volume] in Serum or Plasma

1.11

0.10

1.4

1.2

—

(3028707) Methadone [Presence] in Urine by Screen method

116

1.13

0.09

1.9

2.6

—

(3002582) Erythrocytes [#/volume] in Urine

450

0.94

0.09

2.4

3.5

14.0

57.2

e6/l

1.78

333

(3041008) Bicarbonate [Moles/volume] standard in Arterial cord blood

1.04

0.08

1.0

20.5

19.1

mmol/l

—

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

1.04

0.08

1.5

1.8

—

(3006598) pH of Arterial cord blood

1.04

0.08

1.0

—

(40768804) Tissue Pathology biopsy report

382

1.06

0.08

1.9

1.6

—

(36033641) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Rapid immunoassay

1.10

0.08

1.1

2.1

—

(4035726)

1.08

0.08

1.1

1.6

—

(3023421) Hepatitis B virus surface Ab [Units/volume] in Serum

133

0.90

0.08

1.2

1.4

145.8

294.6

miu/ml

—

(3007844) Epstein Barr virus capsid IgM Ab [Units/volume] in Serum by Immunoassay

1.13

0.08

1.0

1.7

—

(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count

255

0.93

0.07

1.7

3.4

e6/l

0.02

135

(3022948) Iron [Moles/volume] in Serum or Plasma

157

1.09

0.07

1.9

2.9

14.4

14.5

umol/l

0.01

145

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

0.83

0.07

3.4

2.7

—

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

467

0.95

0.07

1.5

1.8

—

(40761511) CBC panel - Blood by Automated count

163

1614

1.05

0.07

6.5

7.3

—

(3013742) Prealbumin [Mass/volume] in Serum or Plasma

128

1.10

0.07

1.8

4.5

0.2

g/l

0.14

122

(3010521) Mycoplasma pneumoniae IgM Ab [Presence] in Serum by Immunoassay

1.12

0.06

1.1

1.2

—

(3016879) Cocaine [Presence] in Urine

227

1.07

0.06

1.5

2.2

—

(3011371) Neisseria gonorrhoeae DNA [Presence] in Specimen by NAA with probe detection

364

0.95

0.05

1.5

2.0

—

(3002109) Cholesterol in LDL/Cholesterol in HDL [Mass Ratio] in Serum or Plasma

140

0.92

0.04

1.2

—

(3028626) Oxygen [Partial pressure] in Capillary blood

220

1.05

0.03

3.2

7.4

10.2

9.6

kpa

0.87

210

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

131

1.07

0.03

1.3

1.8

—

(3023511) Choriogonadotropin [Units/volume] in Urine

139

0.93

0.03

1.1

1.3

—

(3027545) Mycoplasma pneumoniae Ab [Presence] in Serum by Immunoassay

1.09

0.03

1.1

1.3

—

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

158

1589

0.97

0.02

6.3

9.3

19.0

21.7

mg/l

0.46

102

1122

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

469

0.98

0.02

2.6

3.9

—

(3028300) Cannabinoids [Presence] in Urine

248

0.96

0.02

1.5

2.1

—

(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count

258

0.96

0.02

1.7

3.3

0.6

0.7

e6/l

0.12

136

(3008230) Borrelia burgdorferi IgM Ab [Units/volume] in Serum

1.08

0.02

2.7

2.2

—

6.7

—

(3030467) Casts [#/volume] in Urine by Automated count

413

1.02

0.01

2.5

3.6

0.2

0.3

e6/l

0.07

296

(3020961) Endomysium IgA Ab [Titer] in Serum

184

1.04

0.00

1.1

1.3

—

110.6

—

(3027008) Opiates [Presence] in Urine

246

0.97

0.00

1.5

2.1

—

(3007080) Epstein Barr virus nuclear IgG Ab [Units/volume] in Serum

1.04

0.00

1.0

1.8

308.6

184.8

u/ml

—

(3000764) Benzodiazepines [Presence] in Urine

244

0.98

0.00

1.5

2.1

—

(3021337) Troponin I.cardiac [Mass/volume] in Serum or Plasma

167

1.02

0.00

3.5

3.0

2102.5

1917.0

ng/l

—

(3027944) Amphetamines [Presence] in Urine

243

0.99

0.00

1.5

2.1

—

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

675

1.01

0.00

2.5

2.6

—

(1761868) Lipid panel - Serum or Plasma

378

1.01

0.00

1.7

—

(40764126) Parainfluenza virus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.3

—

(3014064) Pregnancy associated plasma protein A [Multiple of the median] in Serum or Plasma

0.00

0.0

1.0

—

(3043257) Herpes virus 6 IgG Ab [Presence] in Cerebral spinal fluid

0.00

0.0

1.0

—

(42869858) Acute and chronic leukemia fusion transcript panel - Blood or Tissue by Molecular genetics method

0.00

0.0

1.6

—

(3014373) Corynebacterium diphtheriae Ab [Units/volume] in Serum

0.00

0.0

1.4

—

(3010015) Selenium [Moles/volume] in Serum or Plasma

0.00

0.0

3.1

—

0.9

—

(3043405) Microscopic observation [Identifier] in Specimen by Non-gynecological cytology method

0.00

0.0

2.6

—

(3000722) Carnitine free (C0) [Moles/volume] in Serum or Plasma

0.00

0.0

2.4

—

23.7

—

(4024509)

0.00

0.0

1.4

—

(3043410) Blood group antigens tested for on Red Blood Cells

0.00

0.0

1.1

—

(3034368) Herpes virus 6 IgM Ab [Presence] in Cerebral spinal fluid

0.00

0.0

1.0

—

(3029080) Hemoglobin [Entitic mass] in Reticulocytes

0.00

0.0

6.2

—

32.8

—

(3031072) Herpes simplex virus 1 IgG Ab [Presence] in Cerebral spinal fluid

0.00

0.0

1.0

—

(3025378) Microscopic observation [Identifier] in Cervix by Cyto stain

0.00

0.0

1.0

—

(3006665) Streptococcus pneumoniae Danish serotype 18C IgG Ab [Mass/volume] in Serum

0.00

0.0

1.3

—

1.8

—

(3048816) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Blood

1.02

0.00

2.2

3.2

1.2

mmol/l

—

(3037121) Protein [Mass/volume] in Urine

0.99

0.00

2.6

6.0

0.3

0.5

g/l

—

(3040370) OLANZapine [Moles/volume] in Serum or Plasma

0.00

0.0

1.6

—

185.6

—

(3032567) Hepatitis B virus DNA [Units/volume] (viral load) in Serum or Plasma by NAA with probe detection

0.00

0.0

1.0

—

(43055361) Metamyelocytes/Leukocytes [Pure number fraction] in Blood by Manual count

0.00

0.0

14.2

—

(3027953) Aldolase [Enzymatic activity/volume] in Serum or Plasma

0.00

0.0

1.6

—

15.9

—

(40771527) Human papilloma virus E6+E7 mRNA [Presence] in Cervix by NAA with probe detection

0.00

0.0

1.8

—

(3041354) Potassium [Moles/volume] in Venous blood

0.00

0.0

1.6

—

3.9

—

(3000899) Streptococcus pneumoniae Danish serotype 7F IgG Ab [Mass/volume] in Serum

0.00

0.0

1.3

—

1.1

—

(3032352) Blasts [#/volume] in Cerebral spinal fluid

0.00

0.0

8.3

—

(37020957) Sapovirus genogroups I+II+IV+V RNA [Presence] in Stool by NAA with probe detection

0.00

0.0

1.2

—

(4146454)

0.00

0.0

3.2

—

(3026820) Hemoglobin [Mass/volume] in Venous cord blood

0.00

0.0

1.0

—

171.5

—

(3030429) Borrelia sp DNA [Identifier] in Specimen by NAA with probe detection

0.00

0.0

1.0

—

(3005593) Pancreatic islet cell Ab [Titer] in Serum

0.00

0.0

1.0

—

(3049539) Genetic diseases [Identifier] in Blood or Tissue by FISH Nominal

0.00

0.0

1.0

—

(723473) SARS-CoV-2 (COVID-19) IgA Ab [Presence] in Serum or Plasma by Immunoassay

0.00

0.0

1.0

—

(3003458) Phosphate [Moles/volume] in Serum or Plasma

240

1.00

0.00

2.5

9.8

1.3

mmol/l

0.34

230

(3005665) Streptococcus pneumoniae Danish serotype 6B IgG Ab [Mass/volume] in Serum

0.00

0.0

1.3

—

4.6

—

(723474) SARS-CoV-2 (COVID-19) IgG Ab [Presence] in Serum or Plasma by Immunoassay

0.00

0.0

1.0

—

(42870298) TPMT gene c.238G>C+460G>A+719A>G [Identifier] in Blood or Tissue by Molecular genetics method Narrative

0.00

0.0

1.3

—

(3045414) Leukocytes [Presence] in Urine

0.98

0.00

1.4

1.5

—

(3014300) Beta 2 glycoprotein 1 IgM Ab [Units/volume] in Serum

0.00

0.0

1.0

—

(3044941) Cell count panel - Synovial fluid

0.00

0.0

1.4

—

(36204094) Streptococcus pneumoniae Danish serotype 23F IgG Ab [Mass/volume] in Serum

0.00

0.0

1.3

—

2.1

—

(3048402) Erythrocytes [#/area] in Urine sediment by Automated count

0.00

0.0

1.0

—

27.2

—

(40761535) Cells panel - Urine sediment

1.00

0.00

2.2

3.9

—

(3012320) Pathologist interpretation of Cerebral spinal fluid tests

0.00

0.0

2.0

—

(36204187) Streptococcus pneumoniae Danish serotype 4 IgG Ab [Mass/volume] in Serum

0.00

0.0

1.3

—

1.4

—

(3041082) Glomerular basement membrane Ab [Titer] in Serum by Immunofluorescence

0.00

0.0

1.0

—

(3000620) Complement C3 [Mass/volume] in Serum or Plasma

0.98

0.00

3.2

1.7

1.0

1.2

g/l

—

(4094501)

0.00

0.0

1.0

—

(3017895) Helicobacter pylori Ab [Units/volume] in Serum

0.89

0.00

1.6

1.7

—

(1001833) Epstein Barr virus DNA [Units/volume] (viral load) in Blood by NAA with probe detection

0.00

0.0

6.3

—

(3013924) Clostridium tetani IgG Ab [Units/volume] in Serum

0.00

0.0

1.3

—

(3005702) Mycobacterium sp identified in Specimen by Organism specific culture

0.00

0.0

1.0

—

(3032868) Hemoglobin electrophoresis panel in Blood

0.00

0.0

1.5

—

(42529201) Cancer Ag 19-9 [Units/volume] in Serum or Plasma by Immunoassay

0.00

0.0

3.0

—

10.6

—

(3007695) Herpes simplex virus 2 IgG Ab [Presence] in Cerebral spinal fluid

0.00

0.0

1.0

—

(3029715) Chromosome analysis.interphase [Interpretation] in Bone marrow by FISH Narrative

0.00

0.0

1.4

—

(3006441) Cardiolipin IgM Ab [Presence] in Serum by Immunoassay

0.00

0.0

1.0

—

(3049714) Procollagen type I.N-terminal propeptide [Mass/volume] in Serum

0.00

0.0

4.0

—

281.7

—

(3038071) Oxygen [Partial pressure] in Mixed venous blood

0.00

0.0

11.4

—

(3005260) Streptococcus pneumoniae Danish serotype 9V IgG Ab [Mass/volume] in Serum

0.00

0.0

1.3

—

1.7

—

(3030862) Granulocytes [#/volume] in Cerebral spinal fluid

0.00

0.0

2.8

—

(3021513) Carbon dioxide [Partial pressure] in Mixed venous blood

0.00

0.0

11.4

—

(3041672) Baker's yeast Ab [Presence] in Serum

0.00

0.0

1.2

—

(3038515) Glucose [Moles/volume] in Venous blood

0.00

0.0

1.6

—

5.8

—

(3028433) Virus identified in Specimen by Culture

0.00

0.0

1.3

—

(3032185) JC virus DNA [#/volume] (viral load) in Serum or Plasma by NAA with probe detection

0.00

0.0

5.7

—

(3003752) BK virus DNA [Units/volume] (viral load) in Urine by NAA with probe detection

0.00

0.0

4.6

—

(3035544) Cardiolipin IgG Ab [Units/volume] in Serum or Plasma

0.00

0.0

1.0

—

(3032773) Endomysium IgG Ab [Titer] in Serum

0.91

0.00

1.0

1.1

—

(3035285) Chloride [Moles/volume] in Venous blood

0.00

0.0

1.6

—

106.8

—

(3011985) Renin [Units/volume] in Plasma

0.00

0.0

1.8

—

60.4

—

(4010399)

0.99

0.00

1.0

1.5

—

(42869457) Rotavirus RNA [Identifier] in Stool by NAA with probe detection

0.00

0.0

1.2

—

(3007798) IgG/Albumin [Mass Ratio] in Cerebral spinal fluid

0.00

0.0

1.0

—

(3007302) Hemoglobin [Mass/volume] in Mixed venous blood

0.00

0.0

2.2

—

(3032390) JC virus DNA [#/volume] (viral load) in Urine by NAA with probe detection

0.00

0.0

4.4

—

(3033705) Calcium.ionized [Moles/volume] in Venous blood

0.00

0.0

1.6

—

(43055222) Platelet function.collagen + Adenosine diphosphate induced and EPINEPHrine induced panel - Blood

0.00

0.0

1.4

—

(3009410) PHENobarbital [Moles/volume] in Serum or Plasma

0.00

0.0

7.2

—

98.8

—

Mortality – FinRegistry

↥

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

Relationships between endpoints

↥

Index endpoint: E4_TALL – Constitutional tall stature

GWS hits: -

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

≡ Risteys

FG R12 + FR

FinnGen R11 + FinRegistry

FinnGen R10 + FinRegistry

FinnGen R10

FinnGen R9

FinnGen R8

FinnGen R7

FinnGen R6

FinnGen R5

FinnGen R4

FinnGen R3

Constitutional tall stature

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

All original rules

Similar endpoints

Case counts by codes

Upset plot

Case counts by code for Constitutional tall stature (E4_TALL)

Summary Statistics

-FinRegistry-

-FinnGen-

Key figures

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

Matched cohort

LabWAS

Mortality – FinRegistry

Relationships between endpoints