mental retardation: ['Subnormal intellectual functioning which originates during the developmental period. This has multiple potential etiologies, including genetic defects and perinatal insults. Intelligence quotient (IQ) scores are commonly used to determine whether an individual is mentally retarded. IQ scores between 70 and 79 are in the borderline mentally retarded range. Scores below 67 are in the retarded range. (Joynt, Clinical Neurology, 1992, Ch55, p28)']
Kela-code for behavioural disturbances in mental retardation
DOID EFO Endpoint Browser PheWeb
F5_KELARET
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
1 out of 7 registries used, show all original rules. |
305 |
4. Check minimum number of eventsNone |
305 |
5. Include endpointsNone |
305 |
6. Filter based on genotype QC (FinnGen only) |
305 |
Control definitions (FinnGen only)
- Control exclude
- F5_MENTRET
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
Kela-code for behavioural disturbances in mental retardation
based on the number of shared cases.
Similar with more cases:
Similar with less cases:
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 12361 | 5572 | 6725 |
| Only index persons | 9845 | 4324 | 5521 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.17 | 0.16 | 0.19 |
| Only index persons | 0.19 | 0.16 | 0.21 |
| Median age at first event (years) | |||
| Whole population | 25.49 | 28.68 | 22.73 |
| Only index persons | 24.12 | 26.82 | 22.01 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 305 | 145 | 160 |
| Unadjusted period prevalence (%) | 0.06 | 0.05 | 0.07 |
| Median age at first event (years) | 24.35 | 26.11 | 22.75 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 287
- Matched controls
- 2870
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
113
Kela drug reimbursment
Anxiety disorders associated with mental retardation
+∞
323.0
287
*
N05AX08
ATC
risperidone; systemic
24.3
89.4
135
101
N05AC02
ATC
thioridazine; oral
65.8
71.2
81
17
F70.0
ICD-10 Finland
Mild mental retardation, With the statement of no, or minimal, impairment of behaviour
832.0
69.0
65
*
112
Kela drug reimbursment
Severe psychotic and other severe mental disorders
18.4
67.4
111
95
N03AG01
ATC
valproic acid; systemic, rectal
20.0
58.2
91
65
F70.1
ICD-10 Finland
Mild mental retardation, Significant impairment of behaviour requiring attention or treatment
658.0
56.6
54
*
N05AH03
ATC
olanzapine; systemic
17.9
54.6
89
70
N05AA02
ATC
levomepromazine; systemic
22.5
48.7
72
42
111
Kela drug reimbursment
Epilepsy and comparable convulsive disorders
14.8
40.9
71
62
F70.9
ICD-10 Finland
Mild mental retardation, Without mention of impairment of behaviour
+∞
37.3
35
*
N04AA02
ATC
biperiden; systemic
27.8
35.9
49
21
F20.9
ICD-10 Finland
Schizophrenia, unspecified
28.5
35.4
48
20
31199
ICD-8 Finland
Mild mental retardation, Other and unspecified
+∞
30.8
29
*
N05AD01
ATC
haloperidol; systemic
16.9
28.6
46
32
N03AF01
ATC
carbamazepine; oral, rectal
9.9
28.1
59
73
N05AF03
ATC
chlorprothixene; systemic
19.5
27.6
42
25
A06AD11
ATC
lactulose; oral
5.7
27.5
89
208
31099
ICD-8 Finland
Borderline mental retardation, Other and unspecified
+∞
26.5
25
*
N05AB03
ATC
perphenazine; systemic, rectal
13.8
26.4
46
39
N05BA01
ATC
diazepam; systemic, rectal
5.5
26.3
89
218
P85
ICPC
Mental retardation
95.0
24.1
26
*
3170A
ICD-9 Finland
Mild mental retardation[LIEVÄ ÄLYLL.KEHITYSVAMMAISUUS,EI KÄYTÄYTYM.HÄIRIÖTÄ]
+∞
23.2
22
*
N05AH04
ATC
quetiapine; oral
4.6
22.6
91
263
WYA30
NOMESCO Finland
Preparations for expected poor cooperation
7.0
22.6
59
102
3170B
ICD-9 Finland
Mild mental retardation[LIEVÄ ÄLYLL.KEHITYSVAMMAISUUS,JOSSA KÄYTÄYTYM.HÄIRI]
+∞
22.2
21
*
F71.1
ICD-10 Finland
Moderate mental retardation, significant impairment of behaviour requiring attention or treatment
237.3
21.9
22
*
G40.9
ICD-10 Finland
Epilepsy, unspecified
11.5
21.7
41
41
J18.9
ICD-10 Finland
Pneumonia, unspecified
3.6
19.1
106
397
F79.9
ICD-10 Finland
Unspecified mental retardation, without mention of impairment of behaviour
+∞
17.9
17
*
F79.0
ICD-10 Finland
Unspecified mental retardation, with the statement of no, or minimal, impairment of behaviour
+∞
17.9
17
*
F29
ICD-10 Finland
Unspecified nonorganic psychosis
9.7
16.7
34
39
N05AC01
ATC
periciazine; systemic
180.0
16.7
17
*
N05AD03
ATC
melperone; systemic
17.0
16.0
25
16
F20.00
ICD-10 Finland
Paranoid schizophrenia continuous
14.9
15.8
26
19
N03AX09
ATC
lamotrigine; oral
7.7
15.8
37
54
F71.0
ICD-10 Finland
Moderate mental retardation, with the statement of no, or minimal, impairment of behaviour
+∞
15.8
15
*
N05BA06
ATC
lorazepam; systemic, sublingual
6.8
15.5
40
67
P72
ICPC
Schizophrenia
15.1
15.3
25
18
34599
ICD-8 Finland
Epilepsy, Other and unspecified
60.0
14.9
17
*
N05AF05
ATC
zuclopenthixol; systemic
26.7
14.9
20
8
183
Kela drug reimbursment
Lamotrigin and topiramate
22.5
14.9
21
10
N05AH02
ATC
clozapine; systemic
16.5
14.7
23
15
N05AX12
ATC
aripiprazole; systemic
7.7
14.6
34
49
N06AB04
ATC
citalopram; systemic
3.2
14.0
89
356
31109
ICD-8 Finland
Mild mental retardation, Following infections and intoxications, Unspecified
+∞
13.6
13
*
N05BE01
ATC
buspirone; oral
11.8
13.3
24
22
N05BA04
ATC
oxazepam; oral
2.9
13.3
95
413
P99
ICPC
Psychological disorders other
10.4
13.0
25
26
M01AH05
ATC
etoricoxib; oral
0.4
12.9
60
1227
G03DC03
ATC
lynestrenol; oral
11.8
12.8
23
21
30041
ICD-8 Finland
Neuroses, Depressiva
25.7
12.6
17
7
N05CD07
ATC
temazepam; oral
3.6
12.5
60
195
M01AB05
ATC
diclofenac; systemic, rectal
0.4
12.5
79
1425
30180
ICD-8 Finland
Personality disorders, Immatura
39.4
12.3
15
*
F83
ICD-10 Finland
Mixed specific developmental disorders
31.5
11.8
15
5
31000
ICD-8 Finland
Borderline mental retardation, Following infections and intoxications, Post infectionem praenatalem
+∞
11.5
11
*
3199A
ICD-9 Finland
Unspecified mental retardation[MUU ÄLYLLINEN KEHITYSVAMMAISUUS,EI KÄYTTÄYTYMIHÄIRI]
+∞
11.5
11
*
31299
ICD-8 Finland
Moderate mental retardation, Other and unspecified
+∞
11.5
11
*
F79.1
ICD-10 Finland
Unspecified mental retardation, significant impairment of behaviour requiring attention or treatment
+∞
11.5
11
*
31009
ICD-8 Finland
Borderline mental retardation, Following infections and intoxications, Unspecified
+∞
11.5
11
*
F70
ICD-10 Finland
Mild mental retardation
+∞
11.5
11
*
N05AA01
ATC
chlorpromazine; systemic, rectal
21.1
11.3
16
8
29599
ICD-8 Finland
Schizophrenia, Unspecified type
45.1
11.0
13
*
A28
ICPC
Limited function/disability NOS
3.2
10.6
60
219
Z02.4
ICD-10 Finland
Examination for driving licence
0.1
10.5
6
398
K59.0
ICD-10 Finland
Constipation
5.7
10.5
30
58
G40.29
ICD-10 Finland
Localization-related (focal)(partial) symptomatic epilepsy and epileptic syndromes with complex partial seizures
10.6
10.2
19
19
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
3.2
9.8
55
199
K59.09
ICD-10 Finland
Constipation, unspecified
5.0
9.7
31
68
3018X
ICD-9 Finland
Personality disorders, Other personality disorders[MUU TAI SEKAMUOTOINEN PERSOONALLISUUSHÄIRIÖ]
56.9
9.7
11
*
N03AF02
ATC
oxcarbazepine; oral
6.3
9.6
25
43
N05BA05
ATC
potassium clorazepate; oral
31.2
9.5
12
*
C03CA01
ATC
furosemide; systemic
2.4
9.3
95
490
G40.20
ICD-10 Finland
Complex partial seizures with only alteration of consciousness
14.3
9.3
15
11
G40.2
ICD-10 Finland
Localization-related (focal)(partial) symptomatic epilepsy and epileptic syndromes with complex partial seizures
14.3
9.3
15
11
M03BX02
ATC
tizanidine; oral
0.4
9.2
73
1264
J01FA10
ATC
azithromycin; systemic
0.4
9.2
73
1263
SPAT1229
SPAT
Assessment of need for aid
3.7
9.1
40
120
E11.9
ICD-10 Finland
Type 2 diabetes mellitus, without complications
2.5
8.8
80
388
29999
ICD-8 Finland
Unspecified psychosis
51.6
8.7
10
*
F20.5
ICD-10 Finland
Residual schizophrenia
51.6
8.7
10
*
188
Kela drug reimbursment
Psychosis requiring demanding treatment
16.9
8.6
13
8
N06AA12
ATC
doxepin; systemic
4.6
8.6
29
68
J15.9
ICD-10 Finland
Bacterial pneumonia, unspecified
3.5
8.5
40
127
F84.9
ICD-10 Finland
Pervasive developmental disorder, unspecified
92.6
8.5
9
*
P29
ICPC
Psychological sympt/compl other
4.7
8.4
28
65
F71.9
ICD-10 Finland
Moderate mental retardation, without mention of impairment of behaviour
+∞
8.4
8
*
A98
ICPC
Health maint/preventive medicine
0.4
8.2
220
2564
F25.9
ICD-10 Finland
Schizoaffective disorder, unspecified
22.8
8.1
11
5
SPAT1253
SPAT
Initiation, adjustment, discontinuation or repetition of medication
2.2
8.0
102
577
SPAT1301
SPAT
No procedures
2.2
7.9
108
628
G21.1
ICD-10 Finland
Other drug-induced secondary parkinsonism
46.2
7.8
9
*
R01AD09
ATC
mometasone; nasal
0.4
7.7
40
823
A10BA02
ATC
metformin; oral
2.2
7.6
88
477
OAB43
SPAT
NA
0.0
7.4
*
210
V700A
ICD-9 Finland
General medical examination, Routine general medical examination at a health care facility
8.7
7.4
15
18
3180A
ICD-9 Finland
Other specified mental retardation, Moderate mental retardation[KESKIVAIKEA ÄLYLL KEHITYSVAMMAISUUS,EI KÄYTÄYT.HÄIR]
+∞
7.3
7
*
F84.0
ICD-10 Finland
Childhood autism
+∞
7.3
7
*
F72.0
ICD-10 Finland
Severe mental retardation, with the statement of no, or minimal, impairment of behaviour
+∞
7.3
7
*
SPAT1234
SPAT
Support of social functional capacity
4.5
7.3
25
60
R62.0
ICD-10 Finland
Delayed milestone
30.8
7.2
9
*
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
2.1
7.2
92
518
F20.30
ICD-10 Finland
Undifferentiated schizophrenia continuous
12.5
7.1
12
10
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
0.5
7.0
54
971
N05AN01
ATC
lithium; oral
7.8
7.0
15
20
N05BA09
ATC
clobazam; oral
14.2
6.9
11
8
G40.22
ICD-10 Finland
Complex partial epileptic seizure with secondary generalization
7.0
6.9
16
24
SPAT1230
SPAT
Aid fitting and borrowing and monitoring of use
2.5
6.7
56
254
65000
ICD-8 Finland
Delivery without mention of complication, Occipital presentation
0.3
6.7
12
402
P28
ICPC
Limited function/disability (P)
12.6
6.6
11
9
J69.0
ICD-10 Finland
Pneumonitis due to food and vomit
7.7
6.5
14
19
N03AX11
ATC
topiramate; oral
5.8
6.4
17
31
N05AL01
ATC
sulpiride; systemic
7.3
6.3
14
20
R45.5
ICD-10 Finland
Hostility
+∞
6.3
6
*
29510
ICD-8 Finland
Schizophrenia, Hebephrenic type
+∞
6.3
6
*
31100
ICD-8 Finland
Mild mental retardation, Following infections and intoxications, Post infectionem praenatalem
+∞
6.3
6
*
3451A
ICD-9 Finland
Epilepsy, Generalised convulsive epilepsy
+∞
6.3
6
*
A46
ICD-10 Finland
Erysipelas
2.5
6.3
51
229
F31.9
ICD-10 Finland
Bipolar affective disorder, unspecified
6.5
6.2
15
24
R32
ICD-10 Finland
Unspecified urinary incontinence
6.0
6.2
16
28
SPAT1033
SPAT
Irrigation or wax removal of outer auditory canal
2.2
6.2
70
372
N06AB03
ATC
fluoxetine; oral
2.6
6.1
43
180
F32.3
ICD-10 Finland
Severe depressive episode with psychotic symptoms
10.3
6.1
11
11
Mortality – FinRegistry
↥Association
Association between endpoint F5_KELARET and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| F5_KELARET | 7.437 [6.07, 9.11] | < 0.001 |
| Birth year | 0.993 [0.98, 1.0] | 0.092 |
During the follow-up period (1.1.1998 — 31.12.2019), 226 out of 1281 females with F5_KELARET died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| F5_KELARET | 4.05 [3.42, 4.8] | < 0.001 |
| Birth year | 0.987 [0.98, 1.0] | 0.01 |
During the follow-up period (1.1.1998 — 31.12.2019), 339 out of 2311 males with F5_KELARET died.
Mortality risk
Mortality risk for people of age
years, who have F5_KELARET.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.86% | 0.752% |
| 5 | 4.271% | 4.842% |
| 10 | 9.845% | 11.323% |
| 15 | 17.928% | 20.999% |
| 20 | 28.931% | 33.385% |
Relationships between endpoints
↥Index endpoint: F5_KELARET – Kela-code for behavioural disturbances in mental retardation
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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