mental retardation: ['Subnormal intellectual functioning which originates during the developmental period. This has multiple potential etiologies, including genetic defects and perinatal insults. Intelligence quotient (IQ) scores are commonly used to determine whether an individual is mentally retarded. IQ scores between 70 and 79 are in the borderline mentally retarded range. Scores below 67 are in the retarded range. (Joynt, Clinical Neurology, 1992, Ch55, p28)']
Kela-code for behavioural disturbances in mental retardation
DOID EFO Endpoint Browser PheWeb
F5_KELARET
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519972 |
1. Apply sex-specific ruleNone |
519972 |
2. Check conditionsNone |
519972 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
1 out of 7 registries used, show all original rules. |
306 |
4. Check minimum number of eventsNone |
306 |
5. Include endpointsNone |
306 |
6. Filter based on genotype QC (FinnGen only) |
282 |
Control definitions (FinnGen only)
- Control exclude
- F5_MENTRET
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
Kela-code for behavioural disturbances in mental retardation
based on the number of shared cases.
Similar with more cases:
Similar with less cases:
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 12361 | 5572 | 6725 |
| Only index persons | 9845 | 4324 | 5521 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.17 | 0.16 | 0.19 |
| Only index persons | 0.19 | 0.16 | 0.21 |
| Median age at first event (years) | |||
| Whole population | 25.49 | 28.68 | 22.73 |
| Only index persons | 24.12 | 26.82 | 22.01 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 282 | 134 | 148 |
| Unadjusted period prevalence (%) | 0.06 | 0.05 | 0.07 |
| Median age at first event (years) | 24.47 | 26.12 | 22.98 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 306
- Matched controls
- 3060
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
113
Kela drug reimbursment
Anxiety disorders associated with mental retardation
+∞
307.7
306
*
N05AC02
ATC
thioridazine; oral
54.7
137.9
81
20
N05AX08
ATC
risperidone; systemic
17.4
134.8
142
145
112
Kela drug reimbursment
Severe psychotic and other severe mental disorders
16.4
114.8
117
111
N03AG01
ATC
valproic acid; systemic, rectal
16.0
97.3
96
85
N05AH03
ATC
olanzapine; systemic
13.9
88.2
95
96
N05AA02
ATC
levomepromazine; systemic
18.4
85.7
75
53
F70.0
ICD-10 Finland
Mild mental retardation, With the statement of no, or minimal, impairment of behaviour
+∞
82.0
75
*
N04AA02
ATC
biperiden; systemic
33.8
77.4
51
18
F20.9
ICD-10 Finland
Schizophrenia, unspecified
24.9
70.5
52
25
F70.1
ICD-10 Finland
Mild mental retardation, Significant impairment of behaviour requiring attention or treatment
+∞
68.3
63
*
111
Kela drug reimbursment
Epilepsy and comparable convulsive disorders
12.7
67.7
74
75
N05AD01
ATC
haloperidol; systemic
16.1
53.1
48
35
N05AF03
ATC
chlorprothixene; systemic
16.5
48.6
43
30
N03AF01
ATC
carbamazepine; oral, rectal
10.1
48.0
60
72
N05AB03
ATC
perphenazine; systemic, rectal
11.4
43.0
48
49
F70.9
ICD-10 Finland
Mild mental retardation, Without mention of impairment of behaviour
454.4
41.1
40
*
G40.9
ICD-10 Finland
Epilepsy, unspecified
11.8
40.5
44
43
P85
ICPC
Mental retardation
+∞
39.4
37
*
A06AD11
ATC
lactulose; oral
5.3
38.4
101
261
N05BA01
ATC
diazepam; systemic, rectal
5.3
36.9
95
240
WYA30
NOMESCO Finland
Treatment of a patient needing special arrangements
6.6
36.4
67
124
31199
ICD-8 Finland
Mild mental retardation, Other and unspecified
+∞
34.0
32
*
N05AX12
ATC
aripiprazole; systemic
9.2
30.2
39
48
N05AH04
ATC
quetiapine; oral
4.3
29.3
102
322
31099
ICD-8 Finland
Borderline mental retardation, Other and unspecified
+∞
28.6
27
*
F71.1
ICD-10 Finland
Moderate mental retardation, significant impairment of behaviour requiring attention or treatment
+∞
26.4
25
*
F29
ICD-10 Finland
Unspecified nonorganic psychosis
8.1
26.0
37
51
P72
ICPC
Schizophrenia
11.3
25.7
28
27
N05BA06
ATC
lorazepam; systemic, sublingual
6.3
25.0
46
84
N03AX09
ATC
lamotrigine; oral
6.8
23.9
40
66
3170A
ICD-9 Finland
Mild mental retardation[LIEVÄ ÄLYLL.KEHITYSVAMMAISUUS,EI KÄYTÄYTYM.HÄIRIÖTÄ]
+∞
23.2
22
*
3170B
ICD-9 Finland
Mild mental retardation[LIEVÄ ÄLYLL.KEHITYSVAMMAISUUS,JOSSA KÄYTÄYTYM.HÄIRI]
+∞
22.1
21
*
P99
ICPC
Psychological disorders other
8.8
22.1
29
36
J18.9
ICD-10 Finland
Pneumonia, unspecified
3.2
20.6
119
507
N06AB04
ATC
citalopram; systemic
3.4
20.5
97
367
F79.0
ICD-10 Finland
Unspecified mental retardation, with the statement of no, or minimal, impairment of behaviour
+∞
20.0
19
*
N05CD07
ATC
temazepam; oral
4.2
20.0
61
171
OAB43, ,
SPAT
0.0
18.5
*
457
N05AD03
ATC
melperone; systemic
24.6
18.1
25
11
F79.9
ICD-10 Finland
Unspecified mental retardation, without mention of impairment of behaviour
+∞
17.9
17
*
F71.0
ICD-10 Finland
Moderate mental retardation, with the statement of no, or minimal, impairment of behaviour
+∞
16.8
16
*
J15.9
ICD-10 Finland
Bacterial pneumonia, unspecified
4.2
16.6
49
133
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
3.6
16.5
64
211
N05AH02
ATC
clozapine; systemic
14.7
16.3
27
20
N05AC01
ATC
periciazine; systemic
50.4
16.2
19
*
N05BE01
ATC
buspirone; oral
6.8
16.1
26
41
Z02.4
ICD-10 Finland
Examination for driving licence
0.1
16.0
6
529
F20.00
ICD-10 Finland
Paranoid schizophrenia continuous
12.7
15.9
28
24
31109
ICD-8 Finland
Mild mental retardation, Following infections and intoxications, Unspecified
+∞
15.8
15
*
N05AF05
ATC
zuclopenthixol; systemic
24.9
15.3
21
9
N03AF02
ATC
oxcarbazepine; oral
6.4
15.0
26
44
N05BA04
ATC
oxazepam; oral
2.7
14.6
106
498
183
Kela drug reimbursment
Lamotrigin and topiramate
18.1
14.5
22
13
SPAT1229
SPAT
Assessment of need for aid
4.1
14.3
42
113
F83
ICD-10 Finland
Mixed specific developmental disorders
44.8
14.3
17
*
K59.09
ICD-10 Finland
Constipation, unspecified
4.1
13.7
41
112
G03DC03
ATC
lynestrenol; oral
13.7
13.6
23
18
F70
ICD-10 Finland
Mild mental retardation
+∞
13.6
13
*
34599
ICD-8 Finland
Epilepsy, Other and unspecified
27.2
13.5
18
7
30041
ICD-8 Finland
Neuroses, Depressiva
18.3
12.7
19
11
F79.1
ICD-10 Finland
Unspecified mental retardation, significant impairment of behaviour requiring attention or treatment
+∞
12.6
12
*
31009
ICD-8 Finland
Borderline mental retardation, Following infections and intoxications, Unspecified
135.3
12.5
13
*
M01AB05
ATC
diclofenac; systemic, rectal
0.4
12.2
92
1586
30180
ICD-8 Finland
Personality disorders, Immatura
31.4
11.8
15
5
31299
ICD-8 Finland
Moderate mental retardation, Other and unspecified
+∞
11.5
11
*
3199A
ICD-9 Finland
Unspecified mental retardation[MUU ÄLYLLINEN KEHITYSVAMMAISUUS,EI KÄYTTÄYTYMIHÄIRI]
+∞
11.5
11
*
31000
ICD-8 Finland
Borderline mental retardation, Following infections and intoxications, Post infectionem praenatalem
+∞
11.5
11
*
M01AH05
ATC
etoricoxib; oral
0.4
11.1
80
1430
188
Kela drug reimbursment
Psychosis requiring demanding treatment
45.0
11.0
13
*
N05BA09
ATC
clobazam; oral
45.0
11.0
13
*
M03BX02
ATC
tizanidine; oral
0.4
10.9
79
1414
N06AA12
ATC
doxepin; systemic
4.1
10.8
31
82
A28
ICPC
Limited function/disability NOS
2.7
10.7
69
300
F71.9
ICD-10 Finland
Moderate mental retardation, without mention of impairment of behaviour
+∞
10.5
10
*
29599
ICD-8 Finland
Schizophrenia, Unspecified type
33.8
10.4
13
*
K03.66
ICD-10 Finland
Tooth plaque
3.5
10.1
37
116
G40.2
ICD-10 Finland
Localization-related (focal)(partial) symptomatic epilepsy and epileptic syndromes with complex partial seizures
17.4
10.0
15
9
J69.0
ICD-10 Finland
Pneumonitis due to food and vomit
10.0
9.9
19
20
A98
ICPC
Health maint/preventive medicine
0.4
9.7
240
2766
SPAT1230
SPAT
Aid fitting and borrowing and monitoring of use
2.6
9.5
62
270
F20.5
ICD-10 Finland
Residual schizophrenia
31.1
9.5
12
*
-1, ,
ICPC
4.8
9.5
22
49
F84.0
ICD-10 Finland
Childhood autism
+∞
9.4
9
*
C03CA01
ATC
furosemide; systemic
2.2
9.4
109
613
SPAT1033
SPAT
Irrigation or wax removal of outer auditory canal
2.4
9.3
75
361
G40.29
ICD-10 Finland
Localization-related (focal)(partial) symptomatic epilepsy and epileptic syndromes with complex partial seizures
8.7
9.2
19
23
N05AA01
ATC
chlorpromazine; systemic, rectal
12.0
9.2
16
14
G40.22
ICD-10 Finland
Complex partial epileptic seizure with secondary generalization
9.5
9.2
18
20
K59.0
ICD-10 Finland
Constipation
3.5
9.0
32
98
SPAT1301
SPAT
No procedures
2.1
9.0
114
663
EBA15
NOMESCO Finland
Extraction of multiple teeth
4.9
9.0
20
43
J44.0
ICD-10 Finland
Chronic obstructive pulmonary disease with acute lower respiratory infection
4.1
8.9
25
65
OAA65, ,
SPAT
0.0
8.7
*
240
29999
ICD-8 Finland
Unspecified psychosis
20.7
8.5
12
6
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
2.4
8.5
68
325
G21.1
ICD-10 Finland
Other drug-induced secondary parkinsonism
92.5
8.5
9
*
F84.9
ICD-10 Finland
Pervasive developmental disorder, unspecified
92.5
8.5
9
*
F72.1
ICD-10 Finland
Severe mental retardation, significant impairment of behaviour requiring attention or treatment
+∞
8.4
8
*
F72.0
ICD-10 Finland
Severe mental retardation, with the statement of no, or minimal, impairment of behaviour
+∞
8.4
8
*
SPAT1253
SPAT
Initiation, adjustment, discontinuation or repetition of medication
2.1
8.3
107
623
R56.8
ICD-10 Finland
Other and unspecified convulsions
3.9
8.2
25
69
U04
ICPC
Incontinence urine
3.7
8.2
26
74
G40.20
ICD-10 Finland
Complex partial seizures with only alteration of consciousness
10.4
8.1
15
15
M01AE01
ATC
ibuprofen; systemic, rectal
0.5
8.1
200
2441
P28
ICPC
Limited function/disability (P)
22.7
8.1
11
5
JN3AA
NOMESCO Finland
Abdominal X-ray examination without contrast
4.2
8.0
22
56
J01FA10
ATC
azithromycin; systemic
0.5
8.0
82
1345
SCA02
NOMESCO Finland
Preventive oral health care
2.8
7.8
43
171
N39.0
ICD-10 Finland
Urinary tract infection, site not specified
2.5
7.8
57
261
J44.8
ICD-10 Finland
Other specified chronic obstructive pulmonary disease
2.9
7.7
39
148
R01AD09
ATC
mometasone; nasal
0.4
7.6
50
977
SPAT1254
SPAT
Administration of medicine
2.4
7.5
58
273
A46
ICD-10 Finland
Erysipelas
2.4
7.4
57
267
R11
ICD-10 Finland
Nausea and vomiting
2.8
7.4
40
158
N05BA05
ATC
potassium clorazepate; oral
11.3
7.4
13
12
N05AL01
ATC
sulpiride; systemic
9.7
7.4
14
15
3180A
ICD-9 Finland
Other specified mental retardation, Moderate mental retardation[KESKIVAIKEA ÄLYLL KEHITYSVAMMAISUUS,EI KÄYTÄYT.HÄIR]
+∞
7.3
7
*
31100
ICD-8 Finland
Mild mental retardation, Following infections and intoxications, Post infectionem praenatalem
+∞
7.3
7
*
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
2.0
7.2
106
641
N39.4
ICD-10 Finland
Other specified urinary incontinence
3.0
7.1
33
120
3820A
ICD-9 Finland
Suppurative and unspecified otitis media, Acute suppurative otitis media
14.2
6.9
11
8
N03AX11
ATC
topiramate; oral
5.9
6.9
18
32
OAA67, ,
SPAT
0.0
6.8
*
199
E11.9
ICD-10 Finland
Type 2 diabetes mellitus, without complications
2.0
6.8
85
484
N06AX03
ATC
mianserin; oral
3.6
6.7
22
64
N03AE01
ATC
clonazepam; systemic
3.3
6.6
26
85
SPAT1234
SPAT
Support of social functional capacity
3.3
6.6
26
85
3018X
ICD-9 Finland
Personality disorders, Other personality disorders[MUU TAI SEKAMUOTOINEN PERSOONALLISUUSHÄIRIÖ]
12.6
6.6
11
9
P29
ICPC
Psychological sympt/compl other
3.0
6.6
29
102
2959A
ICD-9 Finland
Schizophrenic psychoses, Unspecified schizophrenia[ERILAISTUMATON SKITSOFRENIA,TARKEMMIN MÄÄRITTELEMÄT]
71.3
6.4
7
*
78159
ICD-8 Finland
Other symptoms referable to nervous system and special senses, Laesio loquendi alia sive NUD
71.3
6.4
7
*
N05AN01
ATC
lithium; oral
5.4
6.4
18
35
R32
ICD-10 Finland
Unspecified urinary incontinence
5.4
6.4
18
35
N02AJ06
ATC
codeine and paracetamol; systemic
0.5
6.3
51
935
U07
ICPC
Urine symptom/complaint other
3.0
6.3
28
99
Q90.9
ICD-10 Finland
Down syndrome, unspecified
+∞
6.3
6
*
A10BA02
ATC
metformin; oral
1.9
6.2
96
588
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
2.3
6.1
50
241
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
241
2808
0.33
12.62
31.7
20.6
38.23
40.47
%
3.20
195
2639
242
2810
0.34
12.24
31.5
20.5
4.41
4.53
e12/l
3.21
234
2739
242
2810
0.34
12.24
31.7
20.6
131.92
136.60
g/l
4.91
234
2776
242
2807
0.34
11.96
32.0
20.5
238.11
246.10
e9/l
1.08
234
2748
190
2444
0.41
11.95
4.3
4.3
1.29
1.44
mmol/l
7.13
176
2252
199
2504
0.41
11.50
5.0
4.9
2.47
2.73
mmol/l
4.37
184
2308
194
2458
0.42
11.08
4.5
4.4
4.33
4.60
mmol/l
4.01
181
2282
185
2364
0.45
9.99
3.9
3.9
1.51
1.28
mmol/l
2.59
170
2175
230
2678
0.43
8.50
11.4
10.3
24.36
27.03
u/l
0.96
222
2592
190
2352
0.49
7.82
17.7
13.0
89.34
81.92
ml/min/173m2
3.29
135
1911
96
549
2.09
7.71
7.0
4.1
1.02
1.02
kg/l
0.01
30
78
13
15
8.99
6.62
9.8
15.4
1674.62
1355.00
nmol/l
0.59
13
15
12
15
8.27
5.89
6.6
12.2
904.00
804.53
nmol/l
0.17
12
15
113
785
1.70
4.54
2.8
2.6
71.43
61.64
u/l
0.19
105
727
186
2212
0.59
4.52
26.5
16.7
15.06
14.82
%
0.23
181
2182
208
2397
0.59
4.31
5.8
4.5
6.28
5.99
mmol/l
2.28
195
2192
39
198
2.11
4.15
2.0
3.4
85.85
188.86
ng/l
2.17
33
180
28
535
0.48
3.57
2.2
2.9
0.62
0.73
ug/l
0.25
18
345
227
2531
0.60
3.53
22.0
14.2
29.35
23.54
mg/l
1.53
193
1992
202
2314
0.63
3.53
8.3
5.8
42.38
39.91
mmol/mol
2.29
193
2162
135
1686
0.64
3.52
3.7
3.3
67.44
48.43
u/l
0.38
124
1586
0
85
0.00
3.37
0.0
1.7
—
3.83
—
0
58
71
474
1.65
3.19
4.1
3.9
256.87
354.00
ng/l
0.16
54
376
34
586
0.53
3.14
2.3
2.2
—
—
—
0
0
48
295
1.74
2.91
2.2
1.9
—
—
—
0
0
62
410
1.64
2.88
2.2
1.9
—
—
—
0
0
67
454
1.61
2.82
1.5
1.7
1134.85
1214.44
nmol/l
0.32
56
354
47
290
1.73
2.82
5.2
9.1
2.99
1.06
mmol/l
3.05
39
238
122
945
1.48
2.80
6.2
4.0
—
—
—
0
0
0
63
0.00
2.45
0.0
1.7
—
251.79
—
0
57
28
156
1.87
2.35
1.7
1.4
—
—
—
0
0
24
421
0.53
2.32
1.3
1.3
39.22
38.20
iu/ml
—
10
131
45
667
0.62
2.32
2.2
2.7
8117.54
8276.73
umol/l
0.01
39
578
12
47
2.62
2.30
2.3
1.6
—
—
—
0
0
45
291
1.64
2.28
2.2
1.8
—
—
—
0
0
87
654
1.46
2.25
6.1
4.2
0.00
0.00
estimate
-0.00
20
218
240
2588
0.66
2.18
23.5
16.5
4.02
3.98
mmol/l
1.66
230
2521
0
57
0.00
2.07
0.0
1.1
—
—
—
0
0
240
2581
0.67
2.03
23.5
16.5
139.08
139.67
mmol/l
1.93
231
2516
145
1215
1.37
1.97
5.9
3.8
0.00
0.00
estimate
0.50
21
243
5
11
4.60
1.95
7.2
3.7
—
—
—
0
0
5
11
4.60
1.95
7.2
3.7
—
—
—
0
0
94
1165
0.72
1.87
2.7
2.6
—
—
—
0
0
184
1612
1.35
1.82
8.0
4.4
260.67
2925.67
e6/l
—
6
27
145
1228
1.34
1.79
5.9
3.8
0.00
0.00
estimate
-0.00
20
216
71
916
0.71
1.79
4.0
4.7
1.81
2.36
ug/l
0.35
64
823
26
404
0.61
1.62
1.4
1.3
14.65
10.67
u/ml
—
8
160
81
1005
0.74
1.57
2.5
2.6
106.19
128.52
ug/l
0.57
74
917
142
1216
1.31
1.56
8.0
5.1
0.00
0.00
estimate
-0.00
19
223
18
302
0.57
1.52
4.5
4.4
27.36
31.17
%
1.97
11
199
125
1057
1.31
1.49
4.5
4.9
34.38
35.76
g/l
1.53
119
994
16
270
0.57
1.39
2.0
2.2
—
—
—
0
0
41
293
1.46
1.38
7.8
7.9
—
—
—
0
0
27
177
1.58
1.34
1.8
1.6
—
—
—
0
0
10
190
0.51
1.29
1.6
2.4
60.76
66.19
g/l
—
10
174
64
501
1.35
1.29
1.8
1.8
430.86
450.98
pmol/l
0.26
56
423
140
1584
0.79
1.29
3.0
3.0
—
—
—
0
0
6
25
2.43
1.25
1.3
1.2
—
—
—
0
0
59
743
0.74
1.23
3.9
4.0
19.31
21.18
%
0.53
18
337
168
1855
0.79
1.23
4.0
4.1
13.41
11.52
mm/h
1.19
158
1697
7
31
2.29
1.11
1.1
1.8
—
—
—
0
0
7
31
2.29
1.11
1.1
1.8
—
—
—
0
0
16
253
0.61
1.10
1.6
2.0
—
—
—
0
0
7
33
2.15
1.06
1.1
1.3
—
—
—
0
0
141
1253
1.23
1.03
5.3
6.9
1.21
1.21
mmol/l
0.18
126
1074
23
156
1.51
1.02
4.0
3.0
3.04
1.81
mmol/l
0.55
16
118
24
166
1.48
0.98
3.9
3.0
5.26
5.14
kpa
0.27
24
159
5
102
0.48
0.91
1.6
1.9
—
132.00
—
0
5
0
25
0.00
0.79
0.0
1.2
—
172.87
—
0
25
0
26
0.00
0.79
0.0
1.2
—
—
—
0
0
0
26
0.00
0.79
0.0
1.2
—
—
—
0
0
0
27
0.00
0.78
0.0
1.2
—
—
—
0
0
0
27
0.00
0.78
0.0
1.2
—
—
—
0
0
0
27
0.00
0.78
0.0
1.2
—
—
—
0
0
27
355
0.74
0.76
2.0
2.3
17.49
22.94
%
1.25
17
302
19
265
0.70
0.76
4.9
3.3
—
—
—
0
0
109
969
1.19
0.75
2.0
2.0
95.42
96.09
pmol/l
0.05
62
487
144
1312
1.18
0.75
4.9
6.4
12.50
11.51
umol/l
0.09
137
1244
88
767
1.21
0.75
3.9
3.7
5.68
7.92
mg/mmol
0.44
64
481
5
91
0.54
0.68
1.8
1.9
2.48
3.64
g/l
—
5
85
5
91
0.54
0.68
1.8
1.9
—
—
—
0
0
5
91
0.54
0.68
1.8
1.9
6.08
7.27
g/l
—
5
85
7
43
1.64
0.67
1.1
1.7
—
—
—
0
0
7
43
1.64
0.67
1.1
1.7
—
—
—
0
0
19
137
1.41
0.66
2.2
1.5
—
—
—
0
0
217
2274
0.84
0.66
6.1
4.6
2.04
1.92
mu/l
0.67
200
2058
92
818
1.18
0.63
2.3
3.3
2.37
2.35
mmol/l
0.19
79
729
0
21
0.00
0.60
0.0
1.1
—
94.40
—
0
5
11
72
1.55
0.60
1.0
1.3
—
—
—
0
0
0
23
0.00
0.58
0.0
1.1
—
—
—
0
0
11
73
1.53
0.57
1.0
1.1
—
3.31
—
0
8
5
89
0.55
0.57
1.8
1.9
9.48
10.37
g/l
—
5
82
8
125
0.63
0.55
1.0
1.3
—
—
—
0
0
36
433
0.81
0.54
1.5
1.5
—
—
—
0
0
11
157
0.69
0.52
4.5
6.0
24.20
24.82
mmol/l
0.21
11
157
33
397
0.81
0.50
6.2
2.8
5.13
2.06
e6/l
1.26
20
219
83
748
1.15
0.48
2.7
3.2
531.08
1292.53
ng/l
3.99
73
629
13
94
1.40
0.46
1.9
1.8
—
—
—
0
0
5
84
0.59
0.46
1.8
2.0
2.14
3.02
g/l
—
5
78
122
1134
1.13
0.44
4.7
6.1
1.20
1.21
mmol/l
0.94
115
1039
8
56
1.44
0.43
1.3
1.5
—
—
—
0
0
0
15
0.00
0.41
0.0
1.3
—
1.00
—
0
10
8
59
1.37
0.41
1.0
1.3
—
—
—
0
0
0
16
0.00
0.41
0.0
1.6
—
—
—
0
0
0
16
0.00
0.41
0.0
1.0
—
—
—
0
0
0
17
0.00
0.41
0.0
1.2
—
160.56
—
0
17
0
17
0.00
0.41
0.0
1.1
—
—
—
0
0
194
1859
1.12
0.40
4.9
3.8
14.62
14.81
pmol/l
0.47
177
1661
5
35
1.44
0.39
1.4
1.1
—
—
—
0
0
0
19
0.00
0.39
0.0
1.2
—
—
—
0
0
0
19
0.00
0.39
0.0
1.1
—
1.02
—
0
13
5
36
1.40
0.38
1.2
1.8
—
—
—
0
0
15
190
0.78
0.36
2.5
2.8
80.00
64.28
ml/min/173m2
—
6
79
37
425
0.85
0.36
5.6
2.7
0.95
0.98
e6/l
0.03
24
244
5
77
0.64
0.36
1.2
1.4
—
—
—
0
0
6
43
1.40
0.35
1.2
1.7
—
—
—
0
0
124
1168
1.10
0.34
15.8
14.6
1.25
1.27
inr
0.12
39
347
12
91
1.33
0.34
1.8
1.7
—
—
—
0
0
6
86
0.69
0.33
1.2
2.1
—
—
—
0
0
58
524
1.13
0.33
1.7
1.7
1.30
1.28
mg/l
0.02
45
394
11
83
1.34
0.32
3.5
3.1
—
—
—
0
0
130
1231
1.10
0.32
8.7
5.9
27.87
28.03
%
0.05
125
1165
7
54
1.30
0.30
1.4
1.4
—
—
—
0
0
10
130
0.76
0.30
1.6
2.4
0.90
0.65
%
—
10
130
7
57
1.23
0.29
10.3
4.8
20.43
24.83
mg/l
—
7
39
145
1515
0.92
0.29
5.5
5.0
7.17
6.68
mmol/l
1.21
139
1414
64
695
0.90
0.29
5.0
3.1
0.34
0.52
e6/l
0.48
51
528
8
67
1.20
0.26
1.1
1.6
—
—
—
0
0
8
67
1.20
0.26
1.3
1.6
—
—
—
0
0
199
1934
1.08
0.25
7.2
7.6
93.58
79.81
u/l
0.50
190
1813
6
82
0.73
0.24
1.0
1.1
—
—
—
0
0
6
84
0.71
0.24
1.0
1.1
—
—
—
0
0
152
1465
1.07
0.23
12.6
8.8
4.49
4.07
e9/l
1.40
142
1285
126
1208
1.07
0.22
8.8
5.7
57.32
57.06
%
0.07
120
1144
5
42
1.19
0.21
1.0
1.5
—
—
—
0
0
0
11
0.00
0.21
0.0
2.5
—
58.82
—
0
11
0
11
0.00
0.21
0.0
1.5
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
0
10
0.00
0.21
0.0
1.2
—
—
—
0
0
0
10
0.00
0.21
0.0
1.2
—
—
—
0
0
0
12
0.00
0.21
0.0
1.3
—
—
—
0
0
0
12
0.00
0.21
0.0
1.3
—
—
—
0
0
0
12
0.00
0.21
0.0
1.5
—
22.96
—
0
12
0
13
0.00
0.21
0.0
1.3
—
—
—
0
0
0
13
0.00
0.21
0.0
1.4
—
8.04
—
0
13
6
48
1.25
0.20
1.2
1.7
—
—
—
0
0
5
69
0.72
0.17
2.4
1.8
—
—
—
0
0
87
906
0.94
0.15
4.8
3.1
—
—
—
0
0
25
227
1.11
0.14
3.9
6.6
1.22
1.34
mmol/l
0.48
25
222
96
993
0.95
0.13
4.0
3.8
26.72
37.57
ng/l
1.24
62
707
11
96
1.15
0.10
2.2
2.0
—
—
—
0
0
29
309
0.93
0.09
1.5
1.4
—
—
—
0
0
5
47
1.06
0.09
3.4
3.2
60.40
55.53
%
—
5
47
6
70
0.85
0.07
1.0
3.3
—
2.68
—
0
10
12
131
0.91
0.05
1.8
2.1
—
—
—
0
0
14
129
1.09
0.05
1.1
1.0
—
—
—
0
0
12
110
1.09
0.05
4.8
3.2
24.74
25.10
mmol/l
0.16
12
104
102
1005
1.02
0.04
2.1
2.3
77.03
75.70
nmol/l
0.19
95
886
60
588
1.03
0.03
2.2
2.1
2.64
3.09
mg/l
0.97
52
505
31
319
0.97
0.02
4.0
6.8
102.90
103.91
mmol/l
0.60
31
319
54
539
1.00
0.00
1.4
1.3
0.77
1.69
u/ml
1.36
15
151
11
106
1.04
0.00
1.5
2.1
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
6
63
0.95
0.00
1.2
1.3
1.04
0.83
nmol/l
—
6
52
0
6
0.00
-0.00
0.0
1.7
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.5
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.7
—
—
—
0
0
7
76
0.92
-0.00
1.0
1.5
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
8.6
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.5
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
1419.50
—
0
8
5
57
0.88
-0.00
1.6
1.3
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.7
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.5
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.5
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.0
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint F5_KELARET and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| F5_KELARET | 7.437 [6.07, 9.11] | < 0.001 |
| Birth year | 0.993 [0.98, 1.0] | 0.092 |
During the follow-up period (1.1.1998 — 31.12.2019), 226 out of 1281 females with F5_KELARET died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| F5_KELARET | 4.05 [3.42, 4.8] | < 0.001 |
| Birth year | 0.987 [0.98, 1.0] | 0.01 |
During the follow-up period (1.1.1998 — 31.12.2019), 339 out of 2311 males with F5_KELARET died.
Mortality risk
Mortality risk for people of age
years, who have F5_KELARET.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.86% | 0.752% |
| 5 | 4.271% | 4.842% |
| 10 | 9.845% | 11.323% |
| 15 | 17.928% | 20.999% |
| 20 | 28.931% | 33.385% |
Relationships between endpoints
↥Index endpoint: F5_KELARET – Kela-code for behavioural disturbances in mental retardation
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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