No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
143 |
4. Check minimum number of eventsNone |
143 |
5. Include endpointsNone |
143 |
6. Filter based on genotype QC (FinnGen only) |
143 |
Control definitions (FinnGen only)
- Control exclude
- H7_VISUALDISTBLIND
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- H54
- Name in latin
- Amblyopia non specificata unius oculi
Similar endpoints
↥List of similar endpoints to
Moderate visual impairment, monocular
based on the number of shared cases.
Similar with more cases:
- Visual impairment including blindness (binocular or monocular)
- Visual disturbances and blindness
- Diseases of the eye and adnexa
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 987 | 543 | 435 |
| Only index persons | 925 | 517 | 408 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.01 | 0.02 | 0.01 |
| Only index persons | 0.02 | 0.02 | 0.02 |
| Median age at first event (years) | |||
| Whole population | 56.95 | 56.64 | 57.61 |
| Only index persons | 57.76 | 57.48 | 58.11 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 143 | 83 | 60 |
| Unadjusted period prevalence (%) | 0.03 | 0.03 | 0.03 |
| Median age at first event (years) | 60.83 | 56.37 | 67.01 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 129
- Matched controls
- 1290
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H54.6
ICD-10 Finland
Moderate visual impairment, monocular
+∞
186.2
129
*
H53.1
ICD-10 Finland
Subjective visual disturbances
37.3
21.6
27
9
CK2X4
NOMESCO Finland
Optical coherence tomography (OCT) of ocular fundus
7.2
12.7
32
56
XCW99
NOMESCO Finland
Other investigative procedure of eye
5.9
10.9
32
68
CS424
NOMESCO Finland
Visual field testing with Goldmann perimetry
28.6
10.0
13
5
H53.4
ICD-10 Finland
Visual field defects
107.4
9.5
10
*
Z01.0
ICD-10 Finland
Examination of eyes and vision
4.1
9.2
39
122
XCK00
NOMESCO Finland
Perimetry
6.4
9.2
24
44
AA1AD
NOMESCO Finland
CT of head and brain
3.6
8.4
44
163
CS444
NOMESCO Finland
Visual field testing with Octopus automated perimetry
10.4
8.0
15
16
WX140
NOMESCO Finland
Parabulbar anesthesy
8.3
8.0
17
23
S01CA01
ATC
dexamethasone and antiinfectives; ophthalmic (ophth., corticosteroids and antiinfectives in comb.)
3.0
7.7
57
269
H34.1
ICD-10 Finland
Central retinal artery occlusion
+∞
7.4
7
*
CJE20
NOMESCO Finland
Phakoemulsification with implantation of artificial lens in posterior chamber
3.1
7.3
49
215
CK2S4
NOMESCO Finland
Plain photography of ocular fundus
6.8
7.0
17
28
Z96.1
ICD-10 Finland
Presence of intraocular lens
4.3
6.9
26
72
H46
ICD-10 Finland
Optic neuritis
42.3
6.8
8
*
H26.4
ICD-10 Finland
After-cataract
5.0
6.7
21
48
H33.0
ICD-10 Finland
Retinal detachment with retinal break
11.9
6.4
11
10
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
85
559
2.28
5.44
7.8
6.1
1.2
1.2
mmol/l
0.22
73
478
13
31
4.51
5.21
1.7
1.3
502.2
444.7
mg/l
0.27
13
31
26
101
2.92
5.15
2.8
1.7
365.2
354.1
nmol/l
0.11
21
90
12
27
4.76
5.14
1.6
1.1
3.6
3.5
mmol/l
0.45
12
27
43
224
2.32
4.69
6.6
3.0
87.8
369.1
ng/l
1.57
33
170
112
858
2.41
4.59
4.8
3.9
14.5
12.2
mm/h
0.68
99
791
112
867
2.35
4.33
4.1
4.0
14.5
14.6
pmol/l
0.18
98
784
71
475
1.98
3.92
2.3
2.3
80.8
75.5
nmol/l
0.67
60
421
72
487
1.96
3.82
4.9
4.6
35.7
35.8
g/l
0.04
64
462
92
678
2.00
3.79
9.2
9.0
4.3
4.1
e9/l
0.39
83
602
38
212
2.08
3.40
1.6
1.7
1049.7
1192.7
nmol/l
0.51
29
163
127
1077
2.60
3.38
5.6
4.6
1.8
1.9
mu/l
0.64
118
984
65
447
1.83
3.11
2.0
1.9
88.6
97.1
pmol/l
1.15
33
241
111
907
2.00
3.01
9.8
6.9
83.1
78.6
u/l
0.46
103
843
124
1061
2.27
2.88
7.2
5.5
39.9
39.6
mmol/mol
0.11
115
991
7
14
5.20
2.76
1.4
1.1
—
—
—
0
0
7
14
5.20
2.76
1.4
1.1
—
—
—
0
0
62
436
1.75
2.65
4.6
3.8
35.7
55.1
ng/l
0.59
44
300
132
1171
2.65
2.62
21.7
13.1
19.6
22.6
mg/l
0.41
108
932
9
26
3.62
2.53
1.6
1.3
—
—
—
0
0
6
12
5.17
2.42
1.5
1.2
—
—
—
0
0
41
271
1.72
2.12
1.3
1.3
3.4
2.2
u/ml
0.21
13
67
5
10
5.14
2.09
1.8
1.3
2.0
1.7
mmol/l
—
5
10
52
368
1.65
2.08
3.6
3.4
2.3
2.3
mmol/l
0.21
40
325
67
510
1.59
1.98
7.0
5.5
1.2
1.2
mmol/l
0.45
60
465
87
705
1.60
1.96
5.9
3.9
6.5
6.6
mmol/l
0.07
82
648
71
549
1.58
1.95
4.5
4.0
—
—
—
0
0
9
35
2.67
1.83
1.1
1.0
—
5.2
—
0
5
6
18
3.43
1.76
1.3
1.1
—
—
—
0
0
6
18
3.43
1.76
1.3
1.1
—
—
—
0
0
5
13
3.94
1.73
1.6
2.7
18.9
14.5
ug/l
—
5
13
5
13
3.94
1.73
10.6
2.8
—
—
—
0
0
37
252
1.63
1.69
1.7
1.8
0.8
1.0
mg/l
0.34
27
199
21
123
1.83
1.62
7.6
5.6
-0.2
1.2
mmol/l
0.59
14
100
64
501
1.50
1.58
2.5
2.7
122.7
118.5
ug/l
0.06
58
461
13
65
2.10
1.54
1.5
1.3
—
—
—
0
0
92
781
1.50
1.49
4.1
3.0
61.3
44.5
u/l
1.09
82
734
125
1149
1.70
1.28
4.9
4.4
4.6
4.6
mmol/l
0.03
117
1066
112
1004
1.53
1.28
26.5
16.5
13.8
13.7
%
0.59
112
998
117
1061
1.57
1.24
26.2
14.1
38.9
39.6
%
0.28
80
797
8
37
2.23
1.23
1.3
3.1
203.3
174.0
%
—
8
37
133
1248
1.94
1.20
14.5
9.9
25.2
25.8
u/l
0.17
126
1199
46
353
1.45
1.20
4.0
3.4
0.4
0.3
e6/l
0.10
38
265
6
26
2.36
1.20
1.2
1.1
—
—
—
0
0
126
1166
1.68
1.18
5.4
4.9
2.7
2.7
mmol/l
0.06
117
1079
14
80
1.83
1.18
3.4
4.1
2.9
1.6
mmol/l
—
8
64
8
39
2.11
1.17
2.3
1.6
—
—
—
0
0
124
1144
1.63
1.17
4.9
4.3
1.4
1.5
mmol/l
0.72
116
1054
29
204
1.53
1.15
3.3
3.2
2.3
2.2
e6/l
0.02
20
118
13
73
1.86
1.15
2.2
1.5
—
—
—
0
0
120
1100
1.57
1.15
20.3
12.5
84.6
81.6
ml/min/173m2
0.87
109
885
54
431
1.41
1.13
4.8
3.4
—
—
—
0
0
8
41
2.01
1.10
2.0
1.9
—
—
—
0
0
5
21
2.43
1.10
1.0
1.5
—
—
—
0
0
121
1116
1.55
1.07
5.5
4.4
6.0
5.9
mmol/l
0.35
110
1031
18
115
1.65
1.05
3.9
3.3
—
—
—
0
0
5
22
2.32
1.04
1.0
1.5
—
—
—
0
0
7
35
2.05
1.01
1.4
3.2
—
—
—
0
0
69
586
1.34
0.95
4.3
3.7
0.0
0.0
estimate
0.00
15
114
29
214
1.45
0.92
3.3
3.1
0.6
0.8
e6/l
0.63
20
125
10
56
1.84
0.90
1.6
1.5
—
—
—
0
0
84
742
1.32
0.85
2.7
3.1
—
—
—
0
0
23
166
1.46
0.82
2.1
1.7
—
—
—
0
0
41
331
1.33
0.78
3.5
3.2
786.8
1249.1
ng/l
0.90
34
287
6
34
1.80
0.77
1.3
1.4
—
—
—
0
0
118
1105
1.39
0.74
4.5
3.8
1.4
1.3
mmol/l
1.18
111
1011
7
39
1.83
0.73
2.0
2.0
—
—
—
0
0
5
25
2.04
0.73
1.4
1.2
—
—
—
0
0
5
26
1.96
0.71
2.6
1.5
—
—
—
0
0
34
271
1.33
0.70
2.6
2.1
—
—
—
0
0
36
291
1.32
0.67
2.8
2.8
351.2
8361.7
umol/l
1.74
30
249
28
220
1.34
0.63
3.8
3.0
0.6
0.7
ug/l
1.06
20
152
5
30
1.69
0.62
1.4
1.4
—
0.1
—
0
6
8
51
1.60
0.61
1.6
1.7
—
—
—
0
0
17
123
1.43
0.61
7.4
7.6
—
—
—
0
0
12
81
1.53
0.59
8.6
6.5
23.3
25.0
mmol/l
0.49
12
81
66
589
1.22
0.54
6.3
5.0
0.0
0.0
estimate
0.00
15
113
9
63
1.46
0.53
1.2
1.3
—
—
—
0
0
9
63
1.46
0.53
2.0
3.5
1.5
1.2
%
—
9
63
25
200
1.30
0.51
2.8
2.8
2.5
2.4
mmol/l
0.06
20
176
52
457
1.22
0.49
4.9
3.7
—
—
—
0
0
66
596
1.20
0.46
4.6
3.7
0.0
0.0
estimate
0.00
15
110
28
231
1.26
0.46
1.3
1.5
—
—
—
0
0
15
113
1.37
0.45
3.0
4.3
5.7
5.6
kpa
0.14
15
108
7
101
0.68
0.41
1.1
1.6
—
—
—
0
0
0
17
0.00
0.41
0.0
1.1
—
—
—
0
0
5
35
1.44
0.39
1.2
4.6
17.9
26.3
mg/l
—
5
29
5
35
1.44
0.39
1.2
4.6
21.5
220.7
mg/l
—
5
29
9
66
1.39
0.39
1.8
1.7
—
—
—
0
0
23
189
1.26
0.39
1.3
1.3
1.2
12.3
u/ml
—
8
84
0
19
0.00
0.39
0.0
1.7
—
—
—
0
0
5
36
1.40
0.38
2.0
2.5
23.9
25.0
mmol/l
—
5
30
34
294
1.21
0.37
5.4
4.5
22.0
20.8
%
0.19
17
143
15
118
1.30
0.35
2.2
1.7
—
—
—
0
0
14
113
1.26
0.28
2.2
1.6
—
—
—
0
0
9
74
1.23
0.26
3.9
3.7
4.2
4.5
pmol/l
—
9
66
0
10
0.00
0.21
0.0
1.3
—
—
—
0
0
0
10
0.00
0.21
0.0
1.2
—
—
—
0
0
0
10
0.00
0.21
0.0
3.0
—
56.6
—
0
10
0
12
0.00
0.21
0.0
1.7
—
—
—
0
0
0
12
0.00
0.21
0.0
1.5
—
—
—
0
0
0
13
0.00
0.21
0.0
4.2
—
—
—
0
0
16
139
1.17
0.17
2.1
1.9
—
—
—
0
0
14
122
1.16
0.14
1.9
1.7
—
—
—
0
0
30
321
0.92
0.12
5.7
3.9
0.0
0.0
estimate
0.00
16
110
5
63
0.79
0.08
2.8
4.1
24.2
24.3
mmol/l
—
5
58
19
178
1.08
0.06
1.2
1.5
—
—
—
0
0
34
352
0.96
0.04
1.8
1.6
1.6
1.4
mmol/l
0.58
29
303
19
198
0.95
0.02
1.4
1.3
9.2
41.6
iu/ml
—
5
61
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
0.00
0.0
1.4
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
7
77
0.90
0.00
1.3
1.5
—
—
—
0
0
0
8
0.00
0.00
0.0
1.3
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.3
—
—
—
0
0
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint H7_MODVISIMPMONOC and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_MODVISIMPMONOC | 1.208 [0.75, 1.94] | 0.434 |
| Birth year | 0.997 [0.99, 1.01] | 0.49 |
During the follow-up period (1.1.1998 — 31.12.2019), 59 out of 447 females with H7_MODVISIMPMONOC died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_MODVISIMPMONOC | 1.728 [1.06, 2.82] | 0.029 |
| Birth year | 0.99 [0.98, 1.0] | 0.028 |
During the follow-up period (1.1.1998 — 31.12.2019), 70 out of 356 males with H7_MODVISIMPMONOC died.
Mortality risk
Mortality risk for people of age
years, who have H7_MODVISIMPMONOC.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.114% | 0.353% |
| 5 | 0.775% | 2.414% |
| 10 | 1.96% | 5.792% |
| 15 | 3.568% | 10.211% |
| 20 | 6.214% | 16.751% |
Relationships between endpoints
↥Index endpoint: H7_MODVISIMPMONOC – Moderate visual impairment, monocular
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data