No definition available.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519972 |
1. Apply sex-specific ruleNone |
519972 |
2. Check conditionsNone |
519972 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
160 |
4. Check minimum number of eventsNone |
160 |
5. Include endpointsNone |
160 |
6. Filter based on genotype QC (FinnGen only) |
150 |
Control definitions (FinnGen only)
- Control exclude
- H7_VISUALDISTBLIND
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- H54
- Name in latin
- Amblyopia non specificata unius oculi
Similar endpoints
↥List of similar endpoints to
Moderate visual impairment, monocular
based on the number of shared cases.
Similar with more cases:
- Visual impairment including blindness (binocular or monocular)
- Visual disturbances and blindness
- Diseases of the eye and adnexa
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 987 | 543 | 435 |
| Only index persons | 925 | 517 | 408 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.01 | 0.02 | 0.01 |
| Only index persons | 0.02 | 0.02 | 0.02 |
| Median age at first event (years) | |||
| Whole population | 56.95 | 56.64 | 57.61 |
| Only index persons | 57.76 | 57.48 | 58.11 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 150 | 83 | 67 |
| Unadjusted period prevalence (%) | 0.03 | 0.03 | 0.03 |
| Median age at first event (years) | 61.75 | 57.48 | 67.03 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 160
- Matched controls
- 1600
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H54.6
ICD-10 Finland
Moderate visual impairment, monocular
+∞
231.4
160
*
H53.1
ICD-10 Finland
Subjective visual disturbances
45.9
29.9
36
10
CK2X4
NOMESCO Finland
Optical coherence tomography (OCT) of ocular fundus
6.2
19.2
38
76
XCW99
NOMESCO Finland
Other investigative procedure of eye
6.1
18.4
37
75
XCK00
NOMESCO Finland
Perimetry
7.6
16.8
26
40
Z01.0
ICD-10 Finland
Examination of eyes and vision
4.3
16.2
56
178
CK2S4
NOMESCO Finland
Plain photography of ocular fundus
8.2
16.1
23
32
WX140
NOMESCO Finland
Parabulbar anesthesy
7.0
15.2
25
41
CS424
NOMESCO Finland
Visual field testing with Goldmann perimetry
76.1
12.8
14
*
H53.4
ICD-10 Finland
Visual field defects
58.6
9.8
11
*
CS444
NOMESCO Finland
Visual field testing with Octopus automated perimetry
9.6
9.6
19
22
AA1AD
NOMESCO Finland
CT of head and brain
3.0
9.4
58
256
H34.1
ICD-10 Finland
Central retinal artery occlusion
94.8
8.5
9
*
S01ED51
ATC
timolol, combinations; ophthalmic
4.6
8.3
21
51
H26.4
ICD-10 Finland
After-cataract
3.9
8.1
26
76
CJE20
NOMESCO Finland
Phakoemulsification with implantation of artificial lens in posterior chamber
2.6
7.4
64
331
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
2.5
7.4
79
451
Z96.1
ICD-10 Finland
Presence of intraocular lens
3.2
7.4
33
120
S01CA01
ATC
dexamethasone and antiinfectives; ophthalmic
2.4
6.9
69
380
H04.10
ICD-10 Finland
Dry eye syndrome
3.3
6.8
28
96
H33.0
ICD-10 Finland
Retinal detachment with retinal break
7.4
6.7
15
22
R42
ICD-10 Finland
Dizziness and giddiness
2.6
6.0
44
207
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
94
595
2.41
6.80
19.7
12.4
1.37
1.28
inr
0.32
26
180
92
615
2.17
5.38
8.1
6.3
1.22
1.22
mmol/l
0.15
79
534
125
948
2.46
5.34
5.0
4.0
13.77
12.30
mm/h
0.43
112
874
48
252
2.29
5.09
6.5
3.0
2859.89
326.01
ng/l
0.43
37
196
125
964
2.36
4.87
3.9
3.9
14.39
14.61
pmol/l
0.45
109
872
79
521
2.02
4.55
2.3
2.3
81.17
75.97
nmol/l
0.72
67
462
79
536
1.94
4.07
5.0
4.8
35.79
35.74
g/l
0.03
71
510
126
1009
2.17
3.96
9.4
7.1
82.42
78.60
u/l
0.43
117
940
26
116
2.48
3.90
2.8
1.9
365.19
359.16
nmol/l
0.06
21
104
101
755
1.92
3.77
9.2
9.4
4.20
4.13
e9/l
0.12
92
669
42
234
2.08
3.74
1.6
1.7
1038.47
1184.45
nmol/l
0.57
32
179
142
1204
2.59
3.74
5.4
4.6
1.77
1.86
mu/l
0.53
131
1098
139
1187
2.30
3.26
7.0
5.5
39.91
39.64
mmol/mol
0.11
130
1114
149
1315
2.94
3.20
21.8
13.1
18.02
23.04
mg/l
0.97
125
1037
8
17
4.89
2.96
1.4
1.1
—
—
—
0
0
8
17
4.89
2.96
1.4
1.1
—
—
—
0
0
69
484
1.75
2.95
4.5
3.8
33.94
50.83
ng/l
0.56
47
340
7
13
5.58
2.90
8.9
2.8
—
—
—
0
0
71
507
1.72
2.82
2.0
1.8
90.17
94.91
pmol/l
0.56
39
276
10
30
3.48
2.65
1.5
1.3
—
—
—
0
0
44
278
1.80
2.64
1.7
1.7
0.87
0.98
mg/l
0.28
33
216
28
152
2.02
2.64
7.3
6.2
103.82
104.05
mmol/l
0.09
28
152
47
305
1.77
2.58
1.3
1.3
3.05
2.09
u/ml
0.19
15
77
6
11
5.62
2.56
1.7
1.3
1.95
1.70
mmol/l
—
6
11
75
570
1.59
2.20
2.5
2.6
128.23
124.28
ug/l
0.06
69
526
74
561
1.59
2.19
7.6
5.7
1.22
1.21
mmol/l
0.50
66
517
97
785
1.60
2.17
6.3
4.1
6.56
6.60
mmol/l
0.08
91
720
39
254
1.71
2.08
1.7
1.8
417.76
464.85
pmol/l
0.62
33
220
6
15
4.11
2.06
1.5
1.1
—
—
—
0
0
78
614
1.53
1.88
2.9
2.5
—
—
—
0
0
14
67
2.19
1.82
1.7
1.5
—
—
—
0
0
44
307
1.60
1.79
2.5
2.0
3.72
3.01
mg/l
0.60
39
270
16
82
2.06
1.77
2.0
1.5
—
—
—
0
0
5
13
3.93
1.73
1.0
1.2
—
—
—
0
0
155
1468
2.79
1.72
32.0
19.7
39.86
40.06
%
0.13
144
1383
63
481
1.51
1.72
4.4
3.4
—
—
—
0
0
53
391
1.53
1.69
3.8
3.4
0.38
0.34
e6/l
0.07
45
292
10
41
2.53
1.67
1.1
1.1
—
15.11
—
0
7
7
25
2.88
1.67
1.4
1.2
—
—
—
0
0
7
25
2.88
1.67
1.4
1.2
—
—
—
0
0
55
412
1.51
1.63
3.6
3.4
2.34
2.35
mmol/l
0.10
43
366
5
14
3.65
1.63
1.6
2.6
18.90
14.02
ug/l
—
5
14
23
138
1.78
1.62
9.3
6.3
-0.07
1.30
mmol/l
0.67
16
113
10
43
2.41
1.62
2.1
1.7
—
—
—
0
0
150
1399
2.16
1.57
14.1
9.9
25.82
26.02
u/l
0.05
143
1343
141
1290
1.78
1.57
4.8
4.4
4.57
4.62
mmol/l
0.22
132
1198
14
72
2.04
1.54
1.6
1.3
—
—
—
0
0
9
37
2.52
1.50
1.4
3.0
195.11
171.16
%
—
9
37
136
1237
1.66
1.49
20.5
12.5
83.96
81.90
ml/min/173m2
0.56
125
1005
34
233
1.58
1.48
3.2
3.1
1.99
2.00
e6/l
0.00
23
133
102
874
1.46
1.48
4.0
3.1
61.09
45.53
u/l
1.09
91
825
140
1285
1.72
1.45
4.8
4.3
1.40
1.46
mmol/l
0.83
131
1186
142
1309
1.75
1.44
5.2
4.9
2.70
2.74
mmol/l
0.19
132
1212
10
46
2.25
1.43
1.9
1.9
—
—
—
0
0
6
23
2.67
1.38
2.7
6.4
—
157.20
—
0
5
137
1255
1.64
1.37
5.4
4.4
6.01
5.94
mmol/l
0.27
126
1160
5
17
3.00
1.37
1.2
1.1
—
—
—
0
0
15
84
1.87
1.32
3.3
4.1
2.89
1.53
mmol/l
—
8
68
6
25
2.45
1.25
1.0
1.5
—
—
—
0
0
6
25
2.45
1.25
1.2
1.4
—
—
—
0
0
8
37
2.22
1.23
1.1
1.6
0.21
0.22
g/l
—
8
37
129
1176
1.50
1.21
26.1
16.1
14.86
15.04
%
0.15
129
1170
48
370
1.42
1.19
3.6
3.5
4.79
9.94
mg/mmol
1.15
28
235
77
644
1.38
1.19
4.1
3.6
0.00
0.00
estimate
-0.00
17
136
44
334
1.44
1.19
2.6
2.8
351.59
8310.25
umol/l
1.98
37
291
8
39
2.11
1.17
1.1
1.6
1.08
1.16
g/l
—
8
39
8
40
2.05
1.14
1.6
3.1
—
—
—
0
0
40
301
1.44
1.13
2.6
2.2
—
—
—
0
0
47
365
1.41
1.12
3.6
3.3
742.69
1270.74
ng/l
1.21
38
319
5
21
2.42
1.10
2.4
2.9
104.80
105.67
mmol/l
—
5
21
134
1241
1.49
1.05
4.4
3.8
1.36
1.27
mmol/l
0.72
125
1138
33
243
1.45
1.04
3.3
3.0
0.60
0.87
e6/l
0.60
22
140
95
834
1.34
1.02
2.8
3.1
—
—
—
0
0
27
193
1.48
0.99
2.2
1.7
—
—
—
0
0
21
142
1.55
0.98
2.0
4.6
20.71
8.43
ug/l
0.29
16
120
6
28
2.19
0.92
1.2
1.1
—
—
—
0
0
8
42
1.95
0.90
2.1
2.0
—
—
—
0
0
6
30
2.04
0.88
1.0
1.2
—
—
—
0
0
33
254
1.38
0.82
3.9
2.9
0.59
0.73
ug/l
1.05
24
172
9
54
1.71
0.76
1.7
1.7
—
—
—
0
0
7
38
1.88
0.74
1.3
1.5
—
—
—
0
0
74
648
1.26
0.73
6.1
4.9
0.00
0.00
estimate
-0.00
15
127
5
25
2.03
0.73
1.4
1.2
—
—
—
0
0
18
127
1.47
0.71
3.9
3.2
—
—
—
0
0
28
216
1.36
0.69
1.3
1.3
1.14
14.60
u/ml
—
9
100
5
27
1.88
0.69
1.2
1.6
—
—
—
0
0
13
87
1.54
0.65
10.5
6.6
23.63
25.29
mmol/l
0.49
13
87
5
29
1.75
0.64
1.0
1.4
—
19.50
—
0
5
74
656
1.24
0.64
4.3
3.6
0.00
0.00
estimate
-0.00
15
124
5
30
1.69
0.62
2.6
1.4
—
—
—
0
0
19
140
1.41
0.62
7.1
7.9
—
—
—
0
0
0
22
0.00
0.60
0.0
1.1
—
—
—
0
0
5
88
0.55
0.58
1.0
1.0
—
—
—
0
0
6
36
1.69
0.57
1.2
1.3
—
13.90
—
0
7
10
65
1.57
0.57
2.2
3.5
0.72
0.67
%
—
10
65
28
225
1.30
0.54
2.7
3.0
2.46
2.45
mmol/l
0.18
23
194
57
500
1.22
0.53
4.6
3.7
—
—
—
0
0
32
263
1.27
0.52
1.3
1.5
—
—
—
0
0
10
69
1.48
0.45
2.2
3.4
1.47
1.20
%
—
10
69
10
70
1.46
0.43
1.8
1.7
—
—
—
0
0
39
337
1.21
0.42
5.4
4.5
21.20
21.76
%
0.09
21
162
0
16
0.00
0.41
0.0
3.4
—
—
—
0
0
50
444
1.18
0.40
6.2
4.8
3.20
2.71
ug/l
0.16
45
392
0
19
0.00
0.39
0.0
1.7
—
—
—
0
0
9
66
1.39
0.39
1.2
1.3
—
—
—
0
0
5
36
1.40
0.38
3.0
1.6
—
—
—
0
0
17
139
1.25
0.30
2.4
1.7
—
—
—
0
0
31
349
0.86
0.27
5.5
3.8
0.00
0.00
estimate
-0.00
16
124
16
134
1.22
0.24
2.4
1.6
—
—
—
0
0
5
38
1.33
0.23
1.2
4.3
21.50
211.12
mg/l
—
5
31
5
38
1.33
0.23
1.2
4.3
17.88
28.35
mg/l
—
5
31
0
10
0.00
0.21
0.0
1.2
—
—
—
0
0
0
10
0.00
0.21
0.0
4.2
—
77.70
—
0
10
10
80
1.27
0.21
3.6
3.6
4.33
4.55
pmol/l
—
10
72
0
13
0.00
0.21
0.0
1.6
—
—
—
0
0
0
13
0.00
0.21
0.0
1.5
—
—
—
0
0
17
147
1.18
0.19
2.1
1.9
—
—
—
0
0
15
129
1.18
0.17
1.9
1.7
—
—
—
0
0
25
231
1.10
0.11
1.4
1.3
10.03
37.71
iu/ml
—
6
77
5
43
1.17
0.10
1.6
1.9
—
—
—
0
0
10
114
0.87
0.10
1.8
1.7
—
—
—
0
0
36
379
0.94
0.09
1.8
1.6
1.58
1.41
mmol/l
0.41
31
327
18
166
1.10
0.08
5.3
4.6
32.08
31.58
%
0.08
13
113
7
81
0.86
0.07
1.3
1.6
—
—
—
0
0
10
99
1.01
0.00
2.6
2.5
56.20
66.60
ml/min/173m2
—
5
42
20
195
1.03
0.00
1.2
1.5
—
—
—
0
0
0
7
0.00
0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.4
—
—
—
0
0
10
100
1.00
-0.00
1.8
2.6
71.05
67.36
g/l
—
10
92
0
5
0.00
-0.00
0.0
1.4
—
8.05
—
0
5
0
9
0.00
-0.00
0.0
2.4
—
6.97
—
0
9
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
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Mortality – FinRegistry
↥Association
Association between endpoint H7_MODVISIMPMONOC and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_MODVISIMPMONOC | 1.208 [0.75, 1.94] | 0.434 |
| Birth year | 0.997 [0.99, 1.01] | 0.49 |
During the follow-up period (1.1.1998 — 31.12.2019), 59 out of 447 females with H7_MODVISIMPMONOC died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_MODVISIMPMONOC | 1.728 [1.06, 2.82] | 0.029 |
| Birth year | 0.99 [0.98, 1.0] | 0.028 |
During the follow-up period (1.1.1998 — 31.12.2019), 70 out of 356 males with H7_MODVISIMPMONOC died.
Mortality risk
Mortality risk for people of age
years, who have H7_MODVISIMPMONOC.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.114% | 0.353% |
| 5 | 0.775% | 2.414% |
| 10 | 1.96% | 5.792% |
| 15 | 3.568% | 10.211% |
| 20 | 6.214% | 16.751% |
Relationships between endpoints
↥Index endpoint: H7_MODVISIMPMONOC – Moderate visual impairment, monocular
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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