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ILD medications: pirfenidone

ILD_PIRFENIDONE

Endpoint definition

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

519972

1. Apply sex-specific rule

None

519972

2. Check conditions

None

519972

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Medicine purchases: ATC L04AX05

1 out of 7 registries used, show all original rules.

353

4. Check minimum number of events

Min. number of events 3
353

5. Include endpoints

None

353

6. Filter based on genotype QC (FinnGen only)

340

Control definitions (FinnGen only)

Control exclude
ILD_MEDICATIONS

Extra metadata

First used in FinnGen datafreeze
DF2

Case counts by codes

FinnGen case counts by registry codes:

Not enough data for upset plot.

Full data table

Summary Statistics

-FinRegistry-

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

-FinnGen-

Key figures

All Female Male
Number of individuals 340 93 247
Unadjusted period prevalence (%) 0.09 0.03 0.11
Median age at first event (years) 72.00 71.41 72.23

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
353
Matched controls
3530
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
J84.1
ICD-10 Finland
Other interstitial pulmonary diseases with fibrosis
12350.0
307.7
350
22
J84.9
ICD-10 Finland
Interstitial pulmonary disease, unspecified
242.5
307.7
209
21
284
Kela drug reimbursment
Nintedanib and pirfenidone
4503599627370496.0
307.7
344
*
356
Kela drug reimbursment
Nintedanib and pirfenidone
12266.4
307.7
313
*
L04AX05
ATC
pirfenidone; oral
+∞
307.7
353
*
GD1DD
NOMESCO Finland
High resolution CT examination of lungs
46.4
258.3
171
70
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
32.7
169.4
119
54
UGC12
NOMESCO Finland
Flexible bronchoscopy
16.5
134.9
138
132
TGC00
NOMESCO Finland
Bronchial lavation
33.7
132.0
89
35
GD1ED
NOMESCO Finland
Extensive high resolution CT examination of lungs
28.3
122.4
88
41
XG410
NOMESCO Finland
Flow-volume spirometry
20.6
100.0
82
51
H02AB06
ATC
prednisolone; systemic
9.1
90.1
253
770
L01XE31
ATC
[U] nintedanib
+∞
86.0
79
*
J84.8
ICD-10 Finland
Other specified interstitial pulmonary diseases
50.3
81.7
48
11
XG412
NOMESCO Finland
Flow-volume spirometry with bronchospasmolysis
13.3
79.4
84
81
XG470
NOMESCO Finland
Measurement of diffusion capastity of the lungs
20.9
76.6
61
35
GD1AD
NOMESCO Finland
Thorax CT examination
10.8
75.1
94
115
R91
ICD-10 Finland
Abnormal findings on diagnostic imaging of lung
8.0
70.3
121
216
L01EX09
ATC
nintedanib; oral
377.1
63.6
62
*
J96.1
ICD-10 Finland
Chronic respiratory failure
19.3
61.1
50
30
GD1AA
NOMESCO Finland
Thorax X-ray examination
8.1
57.4
297
1394
R03AC02
ATC
salbutamol; inhalant
6.1
53.6
264
1161
Z51.5
ICD-10 Finland
Palliative care
6.4
49.2
100
206
N02AA01
ATC
morphine; systemic, rectal
16.9
48.5
42
28
FB1BD
NOMESCO Finland
Extensive CT examination of arteria pulmonalis
7.2
46.0
78
133
TGD04
NOMESCO Finland
Needle biopsy of the lungs in bronchoscopy
243.9
42.9
43
*
R06.0
ICD-10 Finland
Dyspnoea
4.3
41.1
173
639
R03BA08
ATC
ciclesonide; inhalant
7.2
38.4
63
103
R05
ICD-10 Finland
Cough
4.5
38.1
129
402
L04AA06
ATC
mycophenolic acid; systemic
395.7
36.7
36
*
GDA11
NOMESCO Finland
Thoracoscopic biopsy of lung
109.3
36.5
39
*
J18.9
ICD-10 Finland
Pneumonia, unspecified
4.1
36.3
154
563
R03BB04
ATC
tiotropium bromide; inhalant
5.9
35.0
72
147
GDG10
NOMESCO Finland
Bilateral transplantation of lung
+∞
35.0
33
*
127
Kela drug reimbursment
Transplant complication
+∞
35.0
33
*
Z94.2
ICD-10 Finland
Lung transplant status
+∞
35.0
33
*
DM1QA
NOMESCO Finland
Paranasal sinuses X-ray examination in one projection
12.0
33.4
35
32
R99
ICPC
Respiratory disease other
11.7
32.7
35
33
NK6QA
NOMESCO Finland
Measurement of bone density from two or more locations with X-ray
8.2
32.6
46
63
GD1BT
NOMESCO Finland
Biopsy of lung with X-ray guidance
+∞
29.6
28
*
R4110
NOMESCO Finland
Physiotherapy
3.4
27.3
157
677
J20.9
ICD-10 Finland
Acute bronchitis, unspecified
3.8
25.0
95
312
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
3.9
24.5
86
267
L04AD01
ATC
ciclosporin; systemic
+∞
24.2
23
*
J45.9
ICD-10 Finland
Asthma, unspecified
4.1
24.1
77
223
R03AL01
ATC
fenoterol and ipratropium bromide; inhalant
8.0
23.3
33
45
R05
ICPC
Cough
3.3
23.0
118
467
WX721
NOMESCO Finland
Oxygen concentrator therapy
245.3
22.9
23
*
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
3.3
22.8
118
469
XQ858
NOMESCO Finland
Oxygen partial pressure measurement
26.0
22.6
31
13
XG466
NOMESCO Finland
Sleep oxymetry
7.5
22.0
33
48
L04AX01
ATC
azathioprine; systemic
85.7
22.0
24
*
GCA98
NOMESCO Finland
Other bronchoscopic procedure on bronchus
46.6
21.7
26
6
A02BC02
ATC
pantoprazole; systemic
3.7
21.5
288
1929
R03AK08
ATC
formoterol and beclometasone; inhalant
8.6
21.2
28
35
R28
ICPC
Limited function/disability (R)
22.4
20.3
29
14
FN1AC
NOMESCO Finland
Angiography of heart and/or coronary arteries
2.8
19.4
160
811
TFB00
NOMESCO Finland
Cathetrisation of pulmonal artery
8.2
18.9
26
34
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
2.8
18.8
140
670
XX4BW, ,
NOMESCO Finland
200.2
18.7
19
*
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
3.6
18.1
70
229
GD1CD
NOMESCO Finland
Thorax extensive CT-examination
25.6
17.6
24
10
J01EE01
ATC
sulfamethoxazole and trimethoprim; systemic
5.5
17.5
36
72
J15.9
ICD-10 Finland
Bacterial pneumonia, unspecified
4.1
17.5
53
146
R02
ICPC
Shortness of breath/dyspnoea
3.4
17.2
72
247
WX892
NOMESCO Finland
Monitored bed care
3.9
17.1
57
168
R4190
NOMESCO Finland
Nutritional therapy
6.5
16.7
28
46
ZXE11
NOMESCO Finland
Procedure duration 60 to 89 minutes
5.4
16.6
34
68
GD1BD
NOMESCO Finland
Thorax extensive CT-examination
4.4
16.3
44
111
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
2.5
16.3
192
1132
DM1AA
NOMESCO Finland
Paranasal sinuses X-ray examination without contrast
7.6
15.9
23
32
ZXE06
NOMESCO Finland
Procedure duration 50 to 59 minutes
5.1
15.5
34
72
R03DC03
ATC
montelukast; oral
3.8
14.9
49
143
L04AD02
ATC
tacrolimus; systemic
+∞
14.7
14
*
UGC18
NOMESCO Finland
Flexible bronchoscopy with biopsy of lung
28.6
14.4
19
7
J01AA02
ATC
doxycycline; systemic
3.0
14.2
294
2197
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
2.7
14.2
93
409
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
2.5
13.8
111
539
M05BA04
ATC
alendronic acid; oral
4.1
13.6
39
103
N02AA05
ATC
oxycodone; systemic
2.6
13.5
99
459
PA6DE
NOMESCO Finland
Neck artery ultrasound examination with Doppler method
3.9
13.3
41
114
R03AL02
ATC
salbutamol and ipratropium bromide; inhalant
52.0
12.9
15
*
J45.0
ICD-10 Finland
Predominantly allergic asthma
4.8
12.6
29
64
J01MA14
ATC
moxifloxacin; systemic
3.6
12.4
44
135
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.3
11.9
132
732
XJC10
NOMESCO Finland
Oesophageal pH monitoring
67.2
11.7
13
*
J01FA10
ATC
azithromycin; systemic
2.2
11.6
181
1149
G47.3
ICD-10 Finland
Sleep apnoea
2.3
11.6
113
593
R03AK07
ATC
formoterol and budesonide; inhalant
2.7
11.1
67
280
R03BA01
ATC
beclometasone; inhalant
3.2
11.1
48
167
A03FA01
ATC
metoclopramide; systemic, rectal
2.4
11.0
93
457
R03BA02
ATC
budesonide; inhalant
2.8
10.8
59
234
R01AD58
ATC
fluticasone, combinations; nasal
2.6
10.7
73
324
I25.1
ICD-10 Finland
Atherosclerotic heart disease
2.2
10.7
133
768
203
Kela drug reimbursment
Chronic asthma and similar chronic obstructive pulmonary diseases
2.8
10.6
57
224
ZXE05
NOMESCO Finland
Procedure duration 40 to 49 minutes
4.1
10.4
30
79
D07AB02
ATC
hydrocortisone butyrate; topical
2.2
10.4
115
631
R03AC03
ATC
terbutaline; inhalant
3.1
10.4
46
162
J06.9
ICD-10 Finland
Acute upper respiratory infection, unspecified
2.2
10.2
125
715
R06AE07
ATC
cetirizine; oral
2.1
10.1
135
798
J45
ICD-10 Finland
Asthma
3.9
10.1
31
86
J17.3*B59
ICD-10 Finland
Pneumonia due to Pneumocystis carinii
41.3
10.0
12
*
I26.9
ICD-10 Finland
Pulmonary embolism without mention of acute cor pulmonale
3.6
10.0
34
101
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
2.1
10.0
127
735
M05BA07
ATC
risedronic acid; oral
9.1
9.9
20
23
WW200
NOMESCO Finland
Immunization
9.1
9.9
20
23
TFC00
NOMESCO Finland
Catheterisation of right atrium or ventricle
10.0
9.9
19
20
ZX109
NOMESCO Finland
Instruction on medicine inhalation technique
26.9
9.9
13
5
J45.1
ICD-10 Finland
Nonallergic asthma
4.0
9.7
28
74
J01CA04
ATC
amoxicillin; systemic
2.3
9.6
280
2194
ZX108
NOMESCO Finland
Inhalation
102.7
9.5
10
*
H02AB07
ATC
prednisone; oral
3.6
9.4
32
95
GD1RA
NOMESCO Finland
Dynamic X-ray examination of respiratory organs with convetional X-ray picture
+∞
9.4
9
*
H02AB04
ATC
methylprednisolone; systemic
3.2
9.4
39
132
J01FA06
ATC
roxithromycin; oral
2.0
9.2
141
870
J47
ICD-10 Finland
Bronchiectasis
9.4
9.1
18
20
J22
ICD-10 Finland
Unspecified acute lower respiratory infection
3.9
8.9
27
74
N02AX02
ATC
tramadol; systemic, rectal
2.0
8.8
173
1159
A02BC05
ATC
esomeprazole; systemic
2.0
8.8
155
1000
C03CA01
ATC
furosemide; systemic
2.0
8.7
134
826
XW5WT
NOMESCO Finland
Other blood specimen with radiologicl guidance
92.2
8.4
9
*
GDB11
NOMESCO Finland
Thoracoscopic wedge resection of lung
13.2
8.4
14
11
R5140
NOMESCO Finland
Monitoring the use of the aid
2.5
8.3
59
266
SPAT1245
SPAT
Provision of support and information to patient’s family members
3.7
8.3
27
78
R2110
NOMESCO Finland
Giving the first information
3.8
8.2
25
69
R01AD08
ATC
fluticasone; nasal
2.1
8.1
91
496
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
2.8
8.1
43
167
GX2C5
NOMESCO Finland
Short-lasting oximetry
34.2
8.1
10
*
GX1K5
NOMESCO Finland
Diffusion capacity
34.2
8.1
10
*
ZXE00
NOMESCO Finland
One hour or less
1.9
8.0
145
937
R03AK06
ATC
salmeterol and fluticasone; inhalant
2.7
7.9
44
176
FM1BE
NOMESCO Finland
Cardiac ultrasound examination through oesophagus
2.8
7.9
41
158
WX726
NOMESCO Finland
High-flow oxygen therapy
46.0
7.7
9
*
WX302
NOMESCO Finland
Thoracal epidural anesthesy
3.1
7.7
33
114
IAZ97
NOMESCO Finland
Psychiatric consultation in another specialty
18.9
7.6
11
6
Z3226
NOMESCO Finland
Physiotherapist
2.2
7.6
78
410
E0000UV, ,
ATC
1.9
7.5
142
926
TPH04
NOMESCO Finland
Cathetrisation of vein
2.0
7.5
96
548
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
2.9
7.5
35
127
KA1MN
NOMESCO Finland
Glomerular filtration rate (GFR) Isotope mesurement
81.7
7.4
8
*
WX727
NOMESCO Finland
Estimation of exercise oxygen therapy
+∞
7.3
7
*
5AB14, ,
NOMESCO Finland
+∞
7.3
7
*
XF400
NOMESCO Finland
ECG with 12 standard connections
2.1
7.2
75
396
GX1D5
NOMESCO Finland
Flow volume spirometry
30.7
7.2
9
*
A98
ICPC
Health maint/preventive medicine
4.5
7.1
344
3161
Z01.8
ICD-10 Finland
Other specified special examinations
2.0
7.0
87
491
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
1.8
7.0
163
1130
SAA03
NOMESCO Finland
Extended examination of mouth
1.9
6.8
127
820
WPA11
NOMESCO Finland
Developing a plan for palliative care
40.9
6.8
8
*
J20
ICD-10 Finland
Acute bronchitis
2.7
6.8
38
152
WYA05
NOMESCO Finland
Emergency visit or other similar visit involving procedures
1.8
6.7
153
1050
I27.2
ICD-10 Finland
Other secondary pulmonary hypertension
23.0
6.7
9
*
FM1DE
NOMESCO Finland
Doppler ultrasound examination of heart
2.3
6.6
53
251
FXA00
NOMESCO Finland
Total cardiopulmonary bypass in normothermia or moderate hypothermia at concurrent surgical procedure
3.0
6.6
30
107
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
1.8
6.6
146
992
SPAT1325
SPAT
Vaccination
1.8
6.6
147
1001
WX404
NOMESCO Finland
Intravenous generell anesthesy
2.0
6.6
79
440
SPAT1058
SPAT
PEF monitoring instruction
2.6
6.5
38
155
ZXE03
NOMESCO Finland
Procedure duration 20 to 29 minutes
3.0
6.5
28
97
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
3.1
6.4
26
87
EB1AA
NOMESCO Finland
Intraoral radiographic dental examination
1.8
6.4
181
1320
WPA10
NOMESCO Finland
Proactive palliative care treatment plan
9.5
6.3
12
13
N02BE01
ATC
paracetamol; systemic, rectal
2.5
6.3
320
2802
SAA01
NOMESCO Finland
Simple examination of mouth
1.8
6.3
230
1801
2AX04, ,
NOMESCO Finland
+∞
6.3
6
*
XF622
NOMESCO Finland
Measurement of minute volume of heart
+∞
6.3
6
*
XF614
NOMESCO Finland
Measurement of pulmonary artery pressure
+∞
6.3
6
*
SPAT1217
SPAT
Assessment of need for services (elderly/care support)
2.5
6.2
39
165
I50.9
ICD-10 Finland
Heart failure, unspecified
2.1
6.2
63
329
D07AC01
ATC
betamethasone; topical
1.8
6.1
127
842

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
203
233
19.15
181.62
1.4
1.2
341.64
360.00
titre
0.05
61
53
197
314
12.93
134.80
1.3
1.2
50.63
21.03
iu/ml
1.63
49
79
159
223
12.15
118.33
3.8
1.4
—
—
—
0
0
152
224
11.16
107.94
4.6
5.0
—
—
—
0
0
161
280
9.73
98.87
1.2
1.2
20.59
2.09
u/ml
0.99
29
96
323
1221
20.36
95.13
16.3
3.9
—
—
—
0
0
75
44
21.37
93.79
2.7
1.8
—
—
—
0
0
138
214
9.95
92.77
2.3
1.3
—
—
—
0
0
329
1319
22.98
89.84
13.3
3.5
0.68
0.61
e9/l
6.70
300
1103
329
1325
22.81
89.22
13.3
3.5
0.05
0.04
e9/l
4.35
300
1115
333
1360
26.57
89.17
14.4
3.5
0.25
0.20
e9/l
5.32
307
1164
328
1341
21.42
86.70
13.5
3.5
1.99
2.04
e9/l
0.17
299
1163
277
952
9.87
86.32
10.7
3.1
29.26
33.68
u/l
2.07
277
894
80
67
15.15
82.64
2.0
2.5
143.80
126.83
g/l
1.91
15
53
58
34
20.22
71.98
1.4
1.1
—
—
—
0
0
168
413
6.85
71.30
11.6
7.4
1.44
1.10
mmol/l
0.64
144
328
333
1577
20.62
69.68
16.5
7.0
4.73
4.13
e9/l
5.38
310
1358
334
1623
20.65
66.87
20.3
6.0
9.45
13.05
umol/l
10.31
334
1543
48
31
17.76
56.49
1.1
1.1
3.13
4.73
u/ml
0.29
30
11
67
114
7.02
39.36
1.3
1.4
—
—
—
0
0
38
31
13.62
39.03
1.1
1.0
441.46
251.38
u/ml
1.73
28
13
44
8
62.54
38.34
1.0
1.0
—
—
—
0
0
228
1066
4.22
37.97
3.9
2.8
1087.21
1390.08
ng/l
0.69
209
929
59
104
6.61
33.29
1.2
1.1
191.29
123.91
u/ml
0.77
53
91
40
46
9.68
32.54
1.1
1.1
—
—
—
0
0
196
894
3.68
32.33
5.9
3.3
7.41
7.40
ph
1.18
32
158
34
32
11.65
31.80
5.3
1.9
5.04
4.80
e9/l
0.14
34
32
37
40
10.22
31.47
1.2
1.1
—
—
—
0
0
34
33
11.29
31.15
5.5
2.1
57.79
59.70
%
0.26
34
33
256
1421
3.92
30.45
12.1
5.4
1.19
1.20
mmol/l
2.31
250
1275
143
549
3.70
30.43
2.5
1.6
1.64
1.28
mg/l
0.31
118
435
195
914
3.53
30.27
5.2
4.0
—
—
—
0
0
36
40
9.91
29.99
4.1
2.0
—
—
—
0
0
36
9
44.26
29.60
1.1
1.0
—
—
—
0
0
37
12
34.24
28.78
2.2
2.0
—
—
—
0
0
37
12
34.24
28.78
1.1
1.0
—
—
—
0
0
77
197
4.72
28.61
1.4
1.3
—
—
—
0
0
160
686
3.44
28.24
12.0
5.4
—
—
—
0
0
81
220
4.48
27.86
1.4
1.5
—
—
—
0
0
72
179
4.80
27.67
6.5
2.8
0.77
0.60
%
0.19
39
58
34
39
9.54
27.62
1.2
1.2
1.64
4.72
u/ml
—
5
6
98
313
3.95
27.00
4.6
2.8
139.20
188.91
ng/l
0.97
92
289
76
202
4.52
26.82
6.4
3.0
0.49
0.88
%
1.14
42
69
233
1281
3.41
26.74
18.6
8.2
0.00
0.00
e9/l
1.28
202
1034
75
204
4.40
25.63
1.3
1.5
—
—
—
0
0
257
1536
3.48
24.92
12.5
6.0
1.20
1.21
mmol/l
0.52
237
1304
69
180
4.52
24.84
5.7
3.0
0.11
0.04
%
0.56
35
50
26
5
55.89
22.40
4.2
1.8
25.23
63.48
ug/l
—
26
5
348
2898
15.17
21.26
32.8
13.7
22.47
28.46
mg/l
4.10
330
2252
57
149
4.37
20.29
4.6
4.3
—
—
—
0
0
229
1375
2.89
20.15
7.4
4.6
34.06
34.96
g/l
1.88
218
1278
29
15
20.95
19.86
1.4
1.2
—
—
—
0
0
35
62
6.16
19.39
1.2
1.2
—
—
—
0
0
66
199
3.85
19.31
21.5
9.6
—
—
—
0
0
65
194
3.88
19.30
6.1
3.0
0.10
0.13
%
0.16
30
61
174
953
2.63
17.62
5.2
2.0
128.65
279.29
u/l
1.15
168
888
162
860
2.63
17.46
5.6
3.0
—
—
—
0
0
89
345
3.11
17.44
5.0
1.3
—
—
—
0
0
22
7
33.38
17.24
4.7
1.0
—
—
—
0
0
132
637
2.71
17.20
5.0
3.7
682.76
364.76
ng/l
0.83
124
547
34
66
5.59
17.11
6.7
2.5
—
—
—
0
0
64
206
3.57
16.91
5.5
3.2
7.42
7.40
ph
—
8
27
117
537
2.76
16.76
2.9
1.7
29.41
30.01
s
0.50
117
523
164
913
2.49
15.54
5.5
3.1
0.51
0.52
e6/l
0.02
134
686
116
553
2.63
15.20
4.8
3.0
1.09
1.23
e6/l
0.10
72
323
118
580
2.55
14.40
4.5
2.8
0.65
1.02
e6/l
1.15
77
343
268
1909
2.68
14.30
12.6
4.7
6.85
6.89
mmol/l
0.14
259
1798
127
652
2.48
14.08
4.2
3.5
—
—
—
0
0
96
438
2.64
13.56
2.4
1.2
3.03
2.79
g/l
0.63
80
231
137
742
2.38
13.36
9.4
2.4
349.71
11434.00
umol/l
4.42
125
609
167
989
2.31
13.19
6.0
3.2
32.47
137.84
e6/l
0.91
137
760
276
2031
2.65
13.12
7.0
3.8
—
—
—
0
0
17
6
29.65
13.08
1.1
1.0
—
—
—
0
0
17
6
29.65
13.08
1.1
1.0
—
—
—
0
0
17
6
29.65
13.08
1.1
1.0
—
—
—
0
0
179
1101
2.27
12.80
7.3
3.6
69.60
74.83
e6/l
0.05
144
799
239
1668
2.34
12.45
19.8
17.4
1.33
1.37
inr
0.32
67
460
47
151
3.44
12.32
5.9
3.0
—
—
—
0
0
18
10
18.89
12.17
1.2
1.0
0.61
0.37
g/l
—
10
5
170
1042
2.22
12.05
6.2
3.3
2.34
2.35
mmol/l
0.58
160
900
29
68
4.56
11.72
3.5
2.4
17.10
15.90
%
0.60
14
36
211
1422
2.20
11.64
4.8
3.5
0.00
0.00
estimate
0.50
42
282
39
115
3.69
11.62
5.5
2.3
567.96
988.41
ug/l
0.41
39
109
209
1405
2.20
11.58
6.6
4.6
0.00
0.00
estimate
-0.00
43
265
18
12
15.73
11.43
1.2
1.0
—
—
—
0
0
211
1433
2.17
11.27
4.8
3.5
0.00
0.00
estimate
-0.00
42
249
119
664
2.20
10.34
4.5
2.8
586.65
570.51
mosm/kgh2o
0.39
108
558
68
297
2.60
10.28
19.1
8.3
—
—
—
0
0
73
334
2.49
10.01
2.9
2.5
12.00
10.71
umol/l
0.12
65
301
19
36
5.52
9.74
2.5
1.4
87.67
89.63
%
0.54
19
36
118
670
2.14
9.71
4.4
2.4
2.56
3.93
e6/l
2.59
109
592
20
24
8.76
9.69
1.3
1.0
0.55
0.79
g/l
0.60
11
17
282
2279
2.18
8.01
7.4
4.3
—
—
—
0
0
36
128
3.02
7.96
5.3
3.4
25.18
25.25
mmol/l
0.05
36
118
85
457
2.13
7.86
4.7
1.9
—
—
—
0
0
158
1068
1.87
7.49
3.1
2.0
67.85
77.39
nmol/l
6.14
150
903
340
3045
4.17
6.95
26.2
14.1
—
—
—
0
0
22
63
3.66
6.83
4.7
2.7
—
—
—
0
0
15
21
7.41
6.77
3.0
2.0
—
—
—
0
0
63
319
2.19
6.71
2.5
3.4
2.72
1.98
mmol/l
0.70
53
259
28
96
3.08
6.59
3.8
2.6
—
—
—
0
0
15
23
6.76
6.40
1.0
1.1
—
—
—
0
0
74
409
2.02
6.25
1.2
1.3
—
—
—
0
0
123
814
1.78
5.95
4.7
3.7
0.00
0.00
estimate
-0.00
41
245
12
17
7.27
5.48
1.0
1.1
—
—
—
0
0
8
5
16.31
5.43
1.5
3.8
15.51
13.06
ml/dl
—
8
5
114
765
1.72
5.13
1.6
1.3
—
—
—
0
0
173
1298
1.65
5.09
4.7
3.8
50.17
45.72
ng/l
0.13
145
1023
9
9
10.22
5.05
1.0
1.8
72.22
69.33
%
—
9
9
9
9
10.22
5.05
1.0
1.8
18.22
16.89
%
—
9
9
43
217
2.12
4.60
1.5
1.6
121.70
132.94
ug/g
0.13
33
170
15
44
3.52
4.51
1.5
1.2
—
—
—
0
0
97
645
1.69
4.43
4.9
3.9
1.02
1.02
kg/l
1.48
22
92
7
6
11.87
4.29
1.3
1.0
—
—
—
0
0
7
6
11.87
4.29
1.0
1.0
—
—
—
0
0
150
1121
1.59
4.27
3.2
3.2
42.95
108.63
mg/l
0.58
106
733
53
298
1.92
4.21
2.1
1.5
—
—
—
0
0
9
14
6.56
4.00
5.9
3.3
—
—
—
0
0
124
903
1.58
3.86
3.3
3.0
—
—
—
0
0
32
154
2.19
3.86
2.4
2.6
4.31
6.38
e9/l
0.56
27
117
11
25
4.51
3.65
5.2
3.0
—
—
—
0
0
7
9
7.91
3.57
1.0
1.8
42.46
34.73
%
—
7
9
147
1129
1.52
3.54
3.3
3.1
7.69
7.88
mmol/l
0.23
128
915
60
913
0.59
3.50
3.3
3.5
—
—
—
0
0
211
1752
1.51
3.46
7.5
3.0
55.94
62.21
u/l
0.58
201
1586
65
417
1.68
3.33
1.9
2.5
22.15
23.22
%
0.23
51
346
11
28
4.02
3.31
3.0
4.2
—
—
—
0
0
151
1185
1.48
3.19
3.9
3.8
6.36
8.03
mg/mmol
0.31
104
757
128
980
1.48
3.03
3.2
2.5
61.81
62.63
u/l
0.05
121
902
149
1177
1.46
3.00
2.6
2.2
—
—
—
0
0
5
5
10.12
2.98
1.0
2.2
11.60
7.00
%
—
5
5
5
5
10.12
2.98
1.0
1.0
—
—
—
0
0
5
5
10.12
2.98
1.0
2.2
27.00
29.40
%
—
5
5
46
277
1.76
2.96
3.6
3.1
—
—
—
0
0
296
2684
1.64
2.94
4.4
4.3
2.11
2.05
mu/l
0.32
271
2362
16
64
2.57
2.91
2.6
2.0
—
—
—
0
0
22
103
2.21
2.87
2.6
2.0
35.82
40.11
mg/l
0.17
17
87
22
103
2.21
2.87
2.6
2.0
75.45
109.91
mg/l
0.24
17
87
48
296
1.72
2.84
2.8
2.2
65.00
64.89
e9/l
0.01
30
232
12
39
3.15
2.80
1.5
1.3
—
—
—
0
0
35
200
1.83
2.68
1.8
1.9
—
—
—
0
0
18
81
2.29
2.58
1.2
1.2
—
—
—
0
0
44
273
1.70
2.56
2.1
2.8
4.70
4.35
kpa
0.59
44
266
5
7
7.22
2.55
1.0
1.0
—
—
—
0
0
10
31
3.29
2.53
1.4
1.2
—
—
—
0
0
125
989
1.41
2.38
2.7
2.4
—
—
—
0
0
8
22
3.70
2.37
1.6
1.3
—
—
—
0
0
6
13
4.67
2.28
1.0
1.2
—
—
—
0
0
238
2110
1.39
2.22
3.5
3.5
14.23
14.97
pmol/l
4.79
215
1835
9
31
2.95
2.08
1.2
1.1
—
—
—
0
0
137
1122
1.36
2.07
2.4
2.5
198.33
170.29
ug/l
0.53
130
1008
50
339
1.55
2.07
2.0
1.7
—
—
—
0
0
309
2889
1.56
2.03
7.2
6.8
41.96
40.91
mmol/mol
1.31
291
2630
83
630
1.42
1.97
2.1
3.3
2.46
2.45
mmol/l
0.81
76
553
11
45
2.49
1.95
1.6
1.3
—
—
—
0
0
6
16
3.80
1.94
1.2
1.3
—
—
—
0
0
170
1457
1.32
1.84
3.8
2.5
—
—
—
0
0
13
60
2.21
1.80
1.5
1.2
—
—
—
0
0
321
3044
1.60
1.78
6.0
5.7
2.48
2.56
mmol/l
0.90
298
2752
12
55
2.22
1.69
1.4
1.3
70.25
58.96
mmol/l
0.46
12
47
12
55
2.22
1.69
1.3
1.5
—
—
—
0
0
23
135
1.75
1.67
1.3
1.3
—
—
—
0
0
95
758
1.35
1.65
4.7
3.2
—
—
—
0
0
5
14
3.61
1.62
1.4
1.9
10.00
10.50
mmol/l
—
5
14
6
20
3.03
1.58
1.7
1.3
—
—
—
0
0
109
895
1.32
1.55
1.8
1.7
1.57
1.28
mmol/l
2.69
94
712
90
721
1.33
1.52
2.0
1.8
109210949.32
16581614.72
pmol/l
0.40
76
585
16
90
1.81
1.35
3.6
2.8
30.31
36.07
umol/l
0.80
16
81
310
2953
1.41
1.30
5.2
5.0
1.35
1.40
mmol/l
1.13
282
2660
301
2854
1.37
1.30
4.7
4.5
1.37
1.27
mmol/l
2.18
271
2555
311
2972
1.39
1.20
5.2
5.1
4.33
4.39
mmol/l
0.46
284
2705
10
50
2.03
1.17
1.8
1.6
—
—
—
0
0
312
2987
1.38
1.15
5.6
5.2
6.19
6.16
mmol/l
0.24
290
2669
5
20
2.52
1.15
1.4
1.1
—
—
—
0
0
7
31
2.28
1.11
1.0
1.0
—
—
—
0
0
7
32
2.21
1.08
3.6
2.5
—
—
—
0
0
93
782
1.26
1.08
2.2
2.0
2.87
2.97
mg/l
0.16
82
660
36
265
1.40
1.05
4.4
3.3
—
—
—
0
0
7
34
2.08
1.03
1.1
1.5
—
—
—
0
0
7
35
2.02
1.00
1.6
1.3
—
—
—
0
0
5
23
2.19
0.98
1.0
1.0
—
—
—
0
0
16
101
1.61
0.95
8.9
11.2
—
—
—
0
0
8
45
1.80
0.85
1.9
1.5
—
—
—
0
0
6
111
0.53
0.84
1.0
1.2
—
120.17
—
0
41
153
1390
1.18
0.79
1.8
2.0
86.46
93.34
pmol/l
0.99
82
698
0
26
0.00
0.78
0.0
1.2
—
—
—
0
0
25
183
1.39
0.78
2.5
2.4
—
—
—
0
0
35
271
1.32
0.78
1.4
1.4
—
—
—
0
0
77
662
1.21
0.73
1.7
1.8
1072.12
1223.85
nmol/l
0.94
62
507
7
40
1.76
0.71
1.0
1.1
—
—
—
0
0
5
26
1.94
0.71
1.6
1.2
—
—
—
0
0
5
27
1.86
0.68
1.0
1.1
—
—
—
0
0
26
201
1.32
0.61
5.3
2.3
—
—
—
0
0
0
20
0.00
0.60
0.0
1.1
—
—
—
0
0
0
20
0.00
0.60
0.0
1.1
—
—
—
0
0
0
21
0.00
0.60
0.0
1.1
—
—
—
0
0
0
23
0.00
0.58
0.0
1.0
—
—
—
0
0
41
340
1.23
0.57
1.2
1.3
—
—
—
0
0
11
73
1.52
0.57
2.7
2.0
70.38
59.99
%
1.26
11
73
5
89
0.56
0.56
1.8
1.8
36.20
46.84
nmol/l
—
5
81
6
39
1.55
0.53
4.3
5.6
8.18
6.96
mmol/l
—
6
31
12
85
1.43
0.47
1.0
1.0
—
—
—
0
0
10
141
0.70
0.45
1.2
1.2
—
—
—
0
0
5
33
1.52
0.41
1.2
1.1
—
—
—
0
0
0
15
0.00
0.41
0.0
1.1
—
—
—
0
0
0
15
0.00
0.41
0.0
1.0
—
272.93
—
0
15
0
16
0.00
0.41
0.0
1.6
—
43.91
—
0
11
0
16
0.00
0.41
0.0
1.4
—
121.55
—
0
11
5
34
1.48
0.40
2.4
1.8
—
—
—
0
0
0
18
0.00
0.40
0.0
1.6
—
3537.25
—
0
12
13
170
0.76
0.39
6.6
3.8
—
—
—
0
0
0
19
0.00
0.39
0.0
1.1
—
—
—
0
0
0
19
0.00
0.39
0.0
1.1
—
—
—
0
0
0
19
0.00
0.39
0.0
1.1
—
—
—
0
0
11
80
1.39
0.39
1.1
1.1
—
—
—
0
0
36
417
0.85
0.38
1.2
1.3
—
—
—
0
0
6
44
1.37
0.34
2.3
1.4
—
—
—
0
0
26
306
0.84
0.34
4.9
3.4
—
—
—
0
0
57
523
1.11
0.26
1.2
1.2
1.39
1.46
u/ml
0.03
16
138
12
96
1.26
0.25
1.8
1.6
—
—
—
0
0
16
189
0.84
0.23
3.6
3.0
—
—
—
0
0
5
40
1.25
0.22
1.0
1.7
—
—
—
0
0
88
831
1.08
0.22
1.6
1.5
18.56
20.30
nmol/l
0.59
82
687
5
42
1.19
0.21
1.0
1.1
—
—
—
0
0
0
11
0.00
0.21
0.0
3.9
—
—
—
0
0
0
11
0.00
0.21
0.0
1.0
—
—
—
0
0
0
11
0.00
0.21
0.0
1.8
—
—
—
0
0
0
10
0.00
0.21
0.0
1.6
—
—
—
0
0
0
10
0.00
0.21
0.0
1.5
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
0
12
0.00
0.21
0.0
2.7
—
—
—
0
0
0
13
0.00
0.21
0.0
1.5
—
—
—
0
0
10
80
1.26
0.20
1.7
2.9
—
—
—
0
0
0
14
0.00
0.20
0.0
1.1
—
—
—
0
0
0
14
0.00
0.20
0.0
1.1
—
210.71
—
0
14
0
14
0.00
0.20
0.0
1.8
—
—
—
0
0
105
1099
0.94
0.20
2.8
3.4
0.60
0.75
ug/l
1.22
84
788
14
165
0.84
0.20
3.5
3.7
408.56
2427.60
u/ml
—
9
147
14
118
1.19
0.19
2.1
2.2
172.56
103.87
ug/min
—
9
67
5
68
0.73
0.17
1.0
1.2
0.96
0.78
nmol/l
—
5
56
6
79
0.76
0.15
5.2
2.3
—
—
—
0
0
13
150
0.86
0.15
1.1
1.3
—
46.91
—
0
14
7
90
0.77
0.14
1.1
1.2
—
—
—
0
0
8
99
0.80
0.14
6.3
4.7
—
—
—
0
0
194
1902
1.04
0.13
4.3
5.6
1.89
3.03
ug/l
1.33
175
1686
15
169
0.88
0.13
1.9
2.4
—
13.28
—
0
9
19
172
1.11
0.11
1.1
1.2
—
—
—
0
0
5
44
1.14
0.10
1.4
1.1
—
—
—
0
0
5
46
1.09
0.09
3.4
2.4
—
—
—
0
0
20
185
1.09
0.08
1.2
1.3
—
—
—
0
0
13
122
1.07
0.02
2.9
1.9
—
—
—
0
0
12
128
0.94
0.02
1.2
2.7
4.08
4.32
pmol/l
—
6
108
104
1029
1.02
0.02
4.6
4.1
—
—
—
0
0
12
118
1.02
0.00
2.5
3.4
0.45
0.19
g/l
—
5
50
12
117
1.03
0.00
1.2
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
5
50
1.00
-0.00
2.0
2.8
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
9
92
0.98
-0.00
1.1
1.5
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
2.0
—
15.01
—
0
7
0
6
0.00
-0.00
0.0
4.7
—
—
—
0
0
0
8
0.00
-0.00
0.0
5.5
—
0.75
—
0
8
5
51
0.98
-0.00
2.0
2.8
4.46
4.06
mmol/l
—
5
51
5
50
1.00
-0.00
1.4
1.2
3.38
3.92
mmol/l
—
5
50
5
51
0.98
-0.00
2.0
2.8
105.40
105.45
mmol/l
—
5
51
0
5
0.00
-0.00
0.0
1.6
—
108.40
—
0
5
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0

Mortality – FinRegistry

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

Relationships between endpoints

Index endpoint: ILD_PIRFENIDONE – ILD medications: pirfenidone

GWS hits: -

This endpoint is excluded from FinRegistry analyses (omitted endpoint).