Idiopathic pulmonary fibrosis

IPF

idiopathic pulmonary fibrosis: Idiopathic pulmonary fibrosis (IPF) is a nonneoplastic pulmonary disease that is characterized by the formation of scar tissue within the lungs in the absence of any known cause.

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Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

519972

1. Apply sex-specific rule

None

519972

2. Check conditions

None

519972

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 J84.1
  • Cause of death: ICD-10 J84.1

2 out of 7 registries used, show all original rules.

3085

4. Check minimum number of events

None

3085

5. Include endpoints

None

3085

6. Filter based on genotype QC (FinnGen only)

2992

Control definitions (FinnGen only)

Control exclude
ILD_ENDPOINTS

Extra metadata

First used in FinnGen datafreeze
DF5
Parent code in ICD-10
J84
Name in latin
Morbus pulmonum interstitialis cum fibrosi

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 18549 7438 10834
Only index persons 13181 5367 7814
Unadjusted period prevalence (%)
Whole population 0.27 0.21 0.30
Only index persons 0.26 0.20 0.30
Median age at first event (years)
Whole population 74.28 75.14 73.71
Only index persons 74.01 74.46 73.69

-FinnGen-

Key figures

All Female Male
Number of individuals 2992 1013 1979
Unadjusted period prevalence (%) 0.72 0.36 0.91
Median age at first event (years) 72.70 70.84 73.66

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
3085
Matched controls
30850
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
L04AA06
ATC
mycophenolic acid; systemic
18.8
322.0
260
150
GDA11
NOMESCO Finland
Thoracoscopic biopsy of lung
88.2
317.5
167
20
XG412
NOMESCO Finland
Flow-volume spirometry with bronchospasmolysis
7.3
307.7
537
865
L04AX01
ATC
azathioprine; systemic
10.3
307.7
406
449
R91
ICD-10 Finland
Abnormal findings on diagnostic imaging of lung
6.9
307.7
1105
2296
XG410
NOMESCO Finland
Flow-volume spirometry
10.6
307.7
528
589
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
5.8
307.7
795
1751
TGC00
NOMESCO Finland
Bronchial lavation
31.2
307.7
661
267
J84.8
ICD-10 Finland
Other specified interstitial pulmonary diseases
+∞
307.7
486
*
L04AX05
ATC
pirfenidone; oral
+∞
307.7
385
*
XG470
NOMESCO Finland
Measurement of diffusion capastity of the lungs
12.4
307.7
410
377
J84.9
ICD-10 Finland
Interstitial pulmonary disease, unspecified
3574.0
307.7
1346
7
284
Kela drug reimbursment
Nintedanib and pirfenidone
+∞
307.7
599
*
GD1DD
NOMESCO Finland
High resolution CT examination of lungs
27.1
307.7
1157
669
H02AB06
ATC
prednisolone; systemic
5.0
307.7
2283
11160
GD1ED
NOMESCO Finland
Extensive high resolution CT examination of lungs
21.1
307.7
605
353
J96.1
ICD-10 Finland
Chronic respiratory failure
12.8
307.7
423
379
J84.1
ICD-10 Finland
Other interstitial pulmonary diseases with fibrosis
4503599627370496.0
307.7
3082
*
356
Kela drug reimbursment
Nintedanib and pirfenidone
+∞
307.7
566
*
UGC12
NOMESCO Finland
Flexible bronchoscopy
10.2
307.7
1112
1619
GD1AD
NOMESCO Finland
Thorax CT examination
7.3
307.7
589
969
TGD04
NOMESCO Finland
Needle biopsy of the lungs in bronchoscopy
43.3
294.0
176
43
J18.9
ICD-10 Finland
Pneumonia, unspecified
3.7
282.9
1659
7332
L01EX09
ATC
nintedanib; oral
+∞
281.7
266
*
GCA98
NOMESCO Finland
Other bronchoscopic procedure on bronchus
34.1
277.1
177
55
R06.0
ICD-10 Finland
Dyspnoea
3.5
251.8
1468
6349
L01XE31
ATC
[U] nintedanib
+∞
218.4
207
*
GD1AA
NOMESCO Finland
Thorax X-ray examination
3.4
213.5
2121
12216
FB1BD
NOMESCO Finland
Extensive CT examination of arteria pulmonalis
4.4
179.5
517
1356
NK6QA
NOMESCO Finland
Measurement of bone density from two or more locations with X-ray
5.3
179.0
391
818
R03AC02
ATC
salbutamol; inhalant
2.9
177.1
1944
11350
J92.0
ICD-10 Finland
Pleural plaque with presence of asbestos
7.0
165.4
265
410
GD1CD
NOMESCO Finland
Thorax extensive CT-examination
14.3
162.0
149
109
GD1BD
NOMESCO Finland
Thorax extensive CT-examination
4.4
136.0
373
934
J61
ICD-10 Finland
Pneumoconiosis due to asbestos and other mineral fibres
13.2
133.0
128
101
XQ858
NOMESCO Finland
Oxygen partial pressure measurement
9.6
127.4
152
165
J15.9
ICD-10 Finland
Bacterial pneumonia, unspecified
3.2
126.9
604
2188
127
Kela drug reimbursment
Transplant complication
11.7
125.0
130
116
Z94.2
ICD-10 Finland
Lung transplant status
164.1
120.2
126
8
GDG10
NOMESCO Finland
Bilateral transplantation of lung
406.1
118.4
118
*
R03BB04
ATC
tiotropium bromide; inhalant
2.9
115.4
644
2542
J01MA14
ATC
moxifloxacin; systemic
3.3
113.2
494
1691
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
2.3
112.2
1381
7933
DM1QA
NOMESCO Finland
Paranasal sinuses X-ray examination in one projection
5.2
111.8
244
505
GD1BT
NOMESCO Finland
Biopsy of lung with X-ray guidance
568.1
111.6
110
*
WX721
NOMESCO Finland
Oxygen concentrator therapy
34.7
107.4
68
20
GX1D5
NOMESCO Finland
Flow volume spirometry
47.8
104.3
61
13
M05.8
ICD-10 Finland
Other seropositive rheumatoid arthritis
4.1
103.1
309
822
L04AD01
ATC
ciclosporin; systemic
8.9
101.6
128
149
GX1K5
NOMESCO Finland
Diffusion capacity
20.0
101.1
78
40
P01BA02
ATC
hydroxychloroquine; oral
3.5
98.2
367
1135
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
2.4
94.4
845
4168
UGC18
NOMESCO Finland
Flexible bronchoscopy with biopsy of lung
15.6
94.1
82
54
J84.0
ICD-10 Finland
Alveolar and parietoalveolar conditions
+∞
92.1
88
*
NK4XE
NOMESCO Finland
Joint ultrasound examination not elsewhere classified
3.8
83.4
270
756
R05
ICD-10 Finland
Cough
2.3
82.8
776
3875
J20.9
ICD-10 Finland
Acute bronchitis, unspecified
2.4
82.0
734
3591
J43.9
ICD-10 Finland
Emphysema, unspecified
5.9
81.6
151
268
R03AL01
ATC
fenoterol and ipratropium bromide; inhalant
4.4
81.5
215
518
J17.3*B59
ICD-10 Finland
Pneumonia due to Pneumocystis carinii
20.4
81.1
62
31
M05BA04
ATC
alendronic acid; oral
2.8
80.3
452
1768
XG466
NOMESCO Finland
Sleep oxymetry
4.7
80.0
194
437
R99
ICPC
Respiratory disease other
6.1
80.0
142
242
C03CA01
ATC
furosemide; systemic
2.0
76.8
1545
10271
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
2.5
74.3
546
2433
DM1AA
NOMESCO Finland
Paranasal sinuses X-ray examination without contrast
4.7
71.1
169
374
L04AD02
ATC
tacrolimus; systemic
12.3
70.3
70
58
N02AA01
ATC
morphine; systemic, rectal
4.9
70.0
160
343
ZX108
NOMESCO Finland
Inhalation
11.1
68.7
73
67
R03AK08
ATC
formoterol and beclometasone; inhalant
4.1
67.5
195
502
J47
ICD-10 Finland
Bronchiectasis
5.2
67.4
141
280
R28
ICPC
Limited function/disability (R)
6.2
66.9
116
193
R02
ICPC
Shortness of breath/dyspnoea
2.4
64.7
547
2585
WX892
NOMESCO Finland
Monitored bed care
2.7
64.6
376
1489
F1246, ,
NOMESCO Finland
29.1
64.2
43
15
A02BC02
ATC
pantoprazole; systemic
1.9
59.7
2177
17032
R03BA08
ATC
ciclesonide; inhalant
2.9
59.5
300
1099
XX4BW, ,
NOMESCO Finland
108.9
59.0
64
6
M35.9
ICD-10 Finland
Systemic involvement of connective tissue, unspecified
8.5
58.8
76
91
L04AA13
ATC
[U] leflunomide
5.3
58.2
120
235
I27.8
ICD-10 Finland
Other specified pulmonary heart diseases
16.4
55.6
47
29
L01BA01
ATC
methotrexate; systemic
3.9
55.2
170
458
I50.9
ICD-10 Finland
Heart failure, unspecified
2.0
54.1
802
4673
M34.9
ICD-10 Finland
Systemic sclerosis, unspecified
23.2
53.7
39
17
J22
ICD-10 Finland
Unspecified acute lower respiratory infection
3.1
53.6
242
832
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
1.8
53.1
1081
6977
Z51.5
ICD-10 Finland
Palliative care
2.4
52.9
431
1992
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
1.9
52.5
931
5749
TFB00
NOMESCO Finland
Cathetrisation of pulmonal artery
4.5
51.6
127
289
XW5WT
NOMESCO Finland
Other blood specimen with radiologicl guidance
21.4
50.6
38
18
R4110
NOMESCO Finland
Physiotherapy
1.9
50.5
945
5922
J01FA06
ATC
roxithromycin; oral
1.8
50.4
1233
8377
GX2C5
NOMESCO Finland
Short-lasting oximetry
12.8
50.4
49
39
L04AA01
ATC
[U] ciclosporin
6.9
49.7
77
114
FN1AC
NOMESCO Finland
Angiography of heart and/or coronary arteries
1.8
49.3
1012
6514
J01AA02
ATC
doxycycline; systemic
1.9
48.9
2361
19471
Z01.8
ICD-10 Finland
Other specified special examinations
1.9
48.0
744
4376
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
1.9
47.3
787
4733
GX1E5
NOMESCO Finland
Flow volume spirometry and bronchodilation test
10.0
47.2
54
55
M05.9
ICD-10 Finland
Seropositive rheumatoid arthritis, unspecified
4.2
47.1
127
310
ZX109
NOMESCO Finland
Instruction on medicine inhalation technique
7.1
47.1
71
102
GDA10
NOMESCO Finland
Biopsy of lung
15.4
46.9
41
27
WW200
NOMESCO Finland
Immunization
4.4
46.3
119
280
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
1.7
45.9
1437
10385
TNX10
NOMESCO Finland
Arthrocentesis, unspecified region, unspecified region
2.8
45.5
243
915
J01MA12
ATC
levofloxacin; systemic
1.9
45.0
737
4401
J45.1
ICD-10 Finland
Nonallergic asthma
2.6
44.9
279
1134
D86.0
ICD-10 Finland
Sarcoidosis of lung
6.7
43.8
70
107
TPH04
NOMESCO Finland
Cathetrisation of vein
1.8
43.7
787
4837
J80
ICD-10 Finland
Adult respiratory distress syndrome
11.1
43.3
46
42
J44.8
ICD-10 Finland
Other specified chronic obstructive pulmonary disease
2.0
43.2
531
2873
L04AX03
ATC
methotrexate; systemic
2.4
43.1
308
1338
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
1.9
43.0
609
3461
I26.9
ICD-10 Finland
Pulmonary embolism without mention of acute cor pulmonale
2.6
42.9
264
1068
M35.0
ICD-10 Finland
Sicca syndrome [Sjögren]
5.1
42.8
91
183
I27.9
ICD-10 Finland
Pulmonary heart disease, unspecified
8.7
42.6
54
63
FB1AD
NOMESCO Finland
CT examination of arteria pulmonalis
4.4
42.5
108
252
R03AK06
ATC
salmeterol and fluticasone; inhalant
2.0
42.1
539
2956
A07EC01
ATC
sulfasalazine; oral, rectal
2.5
41.5
275
1152
TFC00
NOMESCO Finland
Catheterisation of right atrium or ventricle
4.7
41.4
98
216
J01EE01
ATC
sulfamethoxazole and trimethoprim; systemic
2.7
41.4
240
942
R03AL06
ATC
olodaterol and tiotropium bromide; inhalant
3.9
40.1
119
312
R04.2
ICD-10 Finland
Haemoptysis
2.9
39.4
196
710
M05BA07
ATC
risedronic acid; oral
3.3
39.2
152
476
XJC10
NOMESCO Finland
Oesophageal pH monitoring
9.2
38.7
47
52
M06.9
ICD-10 Finland
Rheumatoid arthritis, unspecified
3.4
38.4
139
417
Z57.2
ICD-10 Finland
Occupational exposure to dust
9.7
37.7
44
46
5150X
ICD-9 Finland
Postinflammatory pulmonary fibrosis[FIBROSIS PULMONUM E CAUSA IGNOTA]
+∞
37.6
36
*
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
2.0
37.2
443
2361
J45.9
ICD-10 Finland
Asthma, unspecified
1.9
36.7
607
3607
313
Kela drug reimbursment
Abatacept, adalimumab, anakinra, certolizumab pegol, etanercept, golimumab, infliximab, ixekizumab, sarilumab, secukinumab, tocilizumab and ustekinumab (rheumatoid diseases)
4.7
36.7
85
184
I25.1
ICD-10 Finland
Atherosclerotic heart disease
1.6
35.7
1086
7643
NA2AA
NOMESCO Finland
Thoracal spine X-ray examination without contrast
3.6
34.9
119
343
I27.2
ICD-10 Finland
Other secondary pulmonary hypertension
7.5
34.8
50
68
R03AL02
ATC
salbutamol and ipratropium bromide; inhalant
5.2
34.7
72
142
J96.0
ICD-10 Finland
Acute respiratory failure
4.3
34.2
90
216
L01AA01
ATC
cyclophosphamide; systemic
8.0
34.1
46
58
XG460
NOMESCO Finland
Short time oxymetry
3.9
34.1
102
269
XG499
NOMESCO Finland
Other fysiological examination of respiatory function
13.5
34.0
32
24
R81
ICPC
Pneumonia
2.9
33.8
160
563
J43.8
ICD-10 Finland
Other emphysema
9.0
33.3
41
46
Z3226
NOMESCO Finland
Physiotherapist
1.8
33.3
606
3697
J94.1
ICD-10 Finland
Fibrothorax
75.0
32.9
37
5
M05.1
ICD-10 Finland
Rheumatoid lung disease
171.8
32.8
34
*
WX725
NOMESCO Finland
Noninvasive ventilation
2.6
32.6
197
788
J92.9
ICD-10 Finland
Pleural plaque without asbestos
4.1
31.8
87
215
ZXE06
NOMESCO Finland
Procedure duration 50 to 59 minutes
2.8
31.5
160
585
R03BA02
ATC
budesonide; inhalant
1.8
31.5
514
3029
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
2.1
31.2
340
1749
J84
ICD-10 Finland
Other interstitial pulmonary diseases
316.0
30.9
31
*
GD1RA
NOMESCO Finland
Dynamic X-ray examination of respiratory organs with convetional X-ray picture
86.0
30.8
34
*
R5140
NOMESCO Finland
Monitoring the use of the aid
2.0
30.5
363
1926
M34.1
ICD-10 Finland
CR(E)ST syndrome
10.7
30.4
33
31
A02BC05
ATC
esomeprazole; systemic
1.6
30.2
1180
8730
GDB11
NOMESCO Finland
Thoracoscopic wedge resection of lung
6.8
29.3
46
69
A02BC01
ATC
omeprazole; systemic
1.6
29.1
902
6313
281
Kela drug reimbursment
Abatacept, adalimumab, anakinra, certolizumab pegol, etanercept, golimumab, infliximab, ixekizumab, sarilumab, secukinumab and tocilizumab
4.4
29.0
73
169
J99.0*M05.1
ICD-10 Finland
Rheumatoid lung disease
66.6
28.9
33
5
ZXE11
NOMESCO Finland
Procedure duration 60 to 89 minutes
2.7
28.4
152
572
N02AX02
ATC
tramadol; systemic, rectal
1.5
28.3
1338
10283
ND2AA
NOMESCO Finland
Hand and fingers X-ray examination
2.2
28.3
257
1231
FM1BE
NOMESCO Finland
Cardiac ultrasound examination through oesophagus
2.2
28.1
260
1255
M80.4
ICD-10 Finland
Drug-induced osteoporosis with pathological fracture
7.3
28.0
41
57
NH3EA
NOMESCO Finland
Feet X-ray examination with load
4.4
27.9
70
162
J01CA04
ATC
amoxicillin; systemic
1.6
27.8
2221
19082
J67.9
ICD-10 Finland
Hypersensitivity pneumonitis due to unspecified organic dust
42.9
27.7
34
8
XX9XE
NOMESCO Finland
Other ultrasound examination
6.5
27.7
45
70
J43.2
ICD-10 Finland
Centrilobular emphysema
8.6
27.5
35
41
A07AA02
ATC
nystatin; oral
2.3
27.3
228
1055
I50.0
ICD-10 Finland
Congestive heart failure
1.9
27.3
396
2243
KA1MN
NOMESCO Finland
Glomerular filtration rate (GFR) Isotope mesurement
26.7
27.1
37
14
GX2D5
NOMESCO Finland
Sleep oximetry
8.4
27.0
35
42
H02AB07
ATC
prednisone; oral
1.8
26.9
466
2786
5AB14, ,
NOMESCO Finland
75.8
26.8
30
*
WX726
NOMESCO Finland
High-flow oxygen therapy
24.9
26.6
37
15
FXA00
NOMESCO Finland
Total cardiopulmonary bypass in normothermia or moderate hypothermia at concurrent surgical procedure
2.4
26.2
188
814
R03AK03
ATC
[U] fenoterol and ipratropium bromide
2.1
25.9
272
1376
XJC02
NOMESCO Finland
Mesurement of oesophageal pressure and pressure profile of lower oesophageal sphincter
8.5
25.8
33
39
F2680, ,
NOMESCO Finland
22.0
25.6
37
17
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
1.5
25.5
1243
9551
R05
ICPC
Cough
1.6
25.4
656
4367
A02BC03
ATC
lansoprazole; oral
1.6
25.3
909
6540
R03AL09
ATC
formoterol, glycopyrronium bromide and beclometasone; inhalant
2.8
24.7
129
479
J01FA10
ATC
azithromycin; systemic
1.5
24.6
1294
10075
WX872
NOMESCO Finland
Intensive care
2.2
24.5
208
969
XX2RW, ,
NOMESCO Finland
5.3
24.2
48
91
XG474
NOMESCO Finland
Exhalation nntrogen oxide
3.5
23.9
82
238
2AX04, ,
NOMESCO Finland
87.5
23.7
26
*
ZXE40
NOMESCO Finland
More than seven and less than nine hours
3.1
23.3
100
333
R03AK07
ATC
formoterol and budesonide; inhalant
1.7
23.1
504
3204
TPH07
NOMESCO Finland
Cathetrisation of artery
1.8
23.1
411
2470
J12.8
ICD-10 Finland
Other viral pneumonia
5.1
23.1
48
95
J93.1
ICD-10 Finland
Other spontaneous pneumothorax
4.7
22.9
53
115
PA6DE
NOMESCO Finland
Neck artery ultrasound examination with Doppler method
2.1
22.9
224
1104
J45.0
ICD-10 Finland
Predominantly allergic asthma
2.1
22.8
222
1092
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
1.6
22.7
737
5162
J99.0
ICD-10 Finland
Rheumatoid lung disease
231.7
22.6
23
*
ZXE05
NOMESCO Finland
Procedure duration 40 to 49 minutes
2.4
22.5
161
697
IAZ97
NOMESCO Finland
Psychiatric consultation in another specialty
5.5
22.4
43
79
ZXE00
NOMESCO Finland
One hour or less
1.5
22.2
1109
8497
R03BA01
ATC
beclometasone; inhalant
1.7
22.2
416
2537
Z2221
NOMESCO Finland
Medical doctor
1.5
22.1
778
5544
J82
ICD-10 Finland
Pulmonary eosinophilia, not elsewhere classified
9.1
22.1
27
30
L88
ICPC
Rheumatoid/seropositive arthritis
2.7
22.1
122
467
J44.0
ICD-10 Finland
Chronic obstructive pulmonary disease with acute lower respiratory infection
2.1
21.7
229
1160
M01CB01
ATC
sodium aurothiomalate; parenteral
4.0
21.5
60
151
203
Kela drug reimbursment
Chronic asthma and similar chronic obstructive pulmonary diseases
1.6
21.2
602
4079
WZA10
NOMESCO Finland
Extensive medical or dental certificate
4.6
21.0
49
107
R50.9
ICD-10 Finland
Fever, unspecified
1.7
21.0
461
2931
RK110, ,
NOMESCO Finland
5.1
20.9
44
88
3A006, ,
NOMESCO Finland
+∞
20.9
20
*
FM1DE
NOMESCO Finland
Doppler ultrasound examination of heart
1.8
20.6
344
2028
C07AB07
ATC
bisoprolol; oral
1.4
20.1
1718
14448
ZX120
NOMESCO Finland
Intravenous
1.8
20.1
316
1828
Z3231
NOMESCO Finland
Registered nurse
1.5
19.8
833
6138
WX722
NOMESCO Finland
PEEP
2.2
19.7
171
803
RS123, ,
NOMESCO Finland
29.1
19.6
26
9
GD5BD
NOMESCO Finland
Thorax and upper abdomen combined extensive CT examination of
2.9
19.1
92
328
PD4DE
NOMESCO Finland
Lower extremity artery ultrasound examination with Doppler method
2.7
18.9
100
375
M34.8
ICD-10 Finland
Other forms of systemic sclerosis
70.3
18.7
21
*
WZC20
NOMESCO Finland
Multidisciplinary treatment meeting
2.1
18.7
178
868
G47.3
ICD-10 Finland
Sleep apnoea
1.5
18.5
591
4103
Z2446
NOMESCO Finland
Social worker
2.1
18.4
189
947
RK320, ,
NOMESCO Finland
4.4
18.2
45
103
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
2.0
18.2
210
1098
AN1
HP
Coronary angiography
1.6
18.1
486
3241
R03BA05
ATC
fluticasone; inhalant
1.6
18.0
472
3128
M81.4
ICD-10 Finland
Drug-induced osteoporosis
6.5
17.9
29
45
J01FA15
ATC
telithromycin; oral
1.9
17.8
234
1278
GAA31
NOMESCO Finland
Thoracoscopy
7.0
17.8
27
39
A01AB09
ATC
miconazole; local oral
1.8
17.5
271
1559
M34.0
ICD-10 Finland
Progressive systemic sclerosis
24.2
17.3
24
10
XGX32
NOMESCO Finland
Bronchoscopic ultrasonography
4.5
17.0
41
92
R29
ICPC
Respiratory symptom/complaint other
2.0
17.0
183
933
5BA08, ,
NOMESCO Finland
5.2
16.7
34
66
I25.9
ICD-10 Finland
Chronic ischaemic heart disease, unspecified
1.6
16.7
467
3139
XG405
NOMESCO Finland
Education on PEF monitoring
3.5
16.6
56
161
ZXE30
NOMESCO Finland
More than five and less than seven hours
2.1
16.6
165
817
C10AA03
ATC
pravastatin; oral
1.8
16.6
283
1674
R03BB07
ATC
umeclidinium bromide; inhalant
4.4
16.6
41
94
L04AB01
ATC
etanercept; parenteral
4.7
16.6
38
82
R06AE07
ATC
cetirizine; oral
1.4
16.6
992
7760
M05BB03
ATC
alendronic acid and colecalciferol; oral
2.6
16.5
92
354
J99.1
ICD-10 Finland
Respiratory disorders in other diffuse connective tissue disorders
170.9
16.5
17
*
R03DC03
ATC
montelukast; oral
1.6
16.3
363
2308
NH3AA
NOMESCO Finland
Foot and toes X-ray examination
1.9
16.1
225
1253
K44.9
ICD-10 Finland
Diaphragmatic hernia without obstruction or gangrene
1.8
16.0
253
1465
J93.8
ICD-10 Finland
Other pneumothorax
5.2
15.8
32
62
7140A
ICD-9 Finland
Rheumatoid arthritis and other inflammatory polyarthropathies, Rheumatoid arthritis[ARTHRITIS RHEUMATOIDES SEROPOSITIVA]
3.4
15.8
55
162
D86.2
ICD-10 Finland
Sarcoidosis of lung with sarcoidosis of lymph nodes
4.9
15.7
34
70
J99.1*M34.8
ICD-10 Finland
Respiratory disorders in systemic: sclerosis
+∞
15.6
15
*
B01AA03
ATC
warfarin; systemic
1.4
15.6
838
6416
J06.9
ICD-10 Finland
Acute upper respiratory infection, unspecified
1.4
15.6
867
6680
206
Kela drug reimbursment
Chronic coronary artery disease and dyslipidaemia associated with chronic coronary artery disease
1.4
15.5
817
6235
C01DA14
ATC
isosorbide mononitrate; oral
1.4
15.2
728
5454
H05AA02
ATC
teriparatide; parenteral
5.9
15.2
27
46
M05
ICD-10 Finland
Seropositive rheumatoid arthritis
4.5
15.2
36
80
WX882
NOMESCO Finland
High dependency care
2.4
15.1
100
419
M35.1
ICD-10 Finland
Other overlap syndromes
5.8
14.9
27
47
SPAT1262
SPAT
Handing over of treatment supplies
1.5
14.8
583
4206
GDA97
NOMESCO Finland
Other thoracoscopic incision, excision of lesion or repair of lung
57.0
14.8
17
*
J13
ICD-10 Finland
Pneumonia due to Streptococcus pneumoniae
4.0
14.8
41
103
318
Kela drug reimbursment
Teriparatide
5.5
14.8
28
51
J01FF01
ATC
clindamycin; systemic
1.4
14.7
728
5485
XPX04
NOMESCO Finland
Angioscopy
13.3
14.7
25
19
J44.1
ICD-10 Finland
Chronic obstructive pulmonary disease with acute exacerbation, unspecified
2.1
14.6
144
711
D86.9
ICD-10 Finland
Sarcoidosis, unspecified
5.1
14.6
30
59
XX1XW
NOMESCO Finland
Extensive written report from radiologist
2.7
14.6
77
289
GD5AD
NOMESCO Finland
Thorax and upper abdomen combined CT examination of
3.1
14.6
59
191
J99.1*M35.0
ICD-10 Finland
Respiratory disorders in sicca syndrome [Sjögren]
150.7
14.5
15
*
XX1AW
NOMESCO Finland
Written report from X-ray examination without contrast peformed elsewhere
6.0
14.3
25
42
FXD00
NOMESCO Finland
Use of ECHLA without concurrent surgical procedure
27.3
14.3
19
7
D38.1
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Trachea, bronchus and lung
2.2
14.2
126
598
A03
ICPC
Fever
1.6
14.2
328
2104
I26.0
ICD-10 Finland
Pulmonary embolism with mention of acute cor pulmonale
2.5
14.1
85
341
J67.0
ICD-10 Finland
Farmer lung
14.5
14.0
23
16
M32.9
ICD-10 Finland
Systemic lupus erythematosus, unspecified
5.4
14.0
27
50
C01DA02
ATC
glyceryl trinitrate; oral, oral aerosol, sublingual, transdermal
1.4
14.0
864
6754
ND2BA
NOMESCO Finland
Hand and fingers extensive X-ray examination
2.9
13.9
64
223
1CX01, ,
NOMESCO Finland
15.8
13.9
22
14
XF400
NOMESCO Finland
ECG with 12 standard connections
1.5
13.9
548
3952
XX4AW, ,
NOMESCO Finland
53.6
13.8
16
*
M33.1
ICD-10 Finland
Other dermatomyositis
23.9
13.8
19
8
D07AC01
ATC
betamethasone; topical
1.4
13.7
975
7792
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
2.0
13.7
144
729
GD1CT
NOMESCO Finland
Biopsy of the lung with CT guidance
3.0
13.7
61
209
XX1VW
NOMESCO Finland
Written report from radiologist
4.3
13.6
35
83
N02AA05
ATC
oxycodone; systemic
1.4
13.6
630
4683
5163A
ICD-9 Finland
Other alveolar and parietoalveolar pneumopathy, Idiopathic fibrosing alveolitis
+∞
13.5
13
*
R4190
NOMESCO Finland
Nutritional therapy
2.4
13.5
90
378
C34.3
ICD-10 Finland
Malignant neoplasm: Lower lobe, bronchus or lung
2.9
13.5
62
216
H02AB04
ATC
methylprednisolone; systemic
1.5
13.3
390
2641
L04AA24
ATC
abatacept; parenteral
11.5
13.3
24
21
I84.1
ICD-10 Finland
Internal hemorrhoids with other complications
2.6
13.2
77
304
ZX197, ,
NOMESCO Finland
40.2
13.1
16
*
WZC30
NOMESCO Finland
Teaching
1.5
13.1
433
3012
J20
ICD-10 Finland
Acute bronchitis
1.7
13.0
253
1551
I73.0
ICD-10 Finland
Raynaud syndrome
3.4
13.0
45
132
K21.0
ICD-10 Finland
Gastro-oesophageal reflux disease with oesophagitis
1.6
13.0
290
1843
R06.2
ICD-10 Finland
Wheezing
2.1
13.0
122
593
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
1.4
12.9
986
7951
M81.9
ICD-10 Finland
Osteoporosis, unspecified
2.0
12.9
137
696
SPAT1325
SPAT
Vaccination
1.3
12.9
1072
8758
WX408
NOMESCO Finland
General anesthesy, balanced
1.4
12.9
701
5354
J01FA09
ATC
clarithromycin; systemic
1.4
12.8
680
5168
XX2XT
NOMESCO Finland
Other injection with other radiological guidance
10.5
12.7
24
23
TNB11
NOMESCO Finland
Injection of diagnostic or therapeutic substance in shoulder joint
4.9
12.6
27
55
ZXE03
NOMESCO Finland
Procedure duration 20 to 29 minutes
1.9
12.5
160
868
C01DA08
ATC
isosorbide dinitrate; oral, oral aerosol, sublingual, transdermal
1.3
12.5
961
7753
AK3
HP
BLTX (both lung transplants)
130.5
12.4
13
*
ND2DA
NOMESCO Finland
Bilateral hand X-ray examination
3.0
12.4
55
188
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
1.7
12.4
245
1509
TDM10
NOMESCO Finland
Puncture of maxillary antrum
2.3
12.4
91
400
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
1.5
12.2
380
2605
NH3BA
NOMESCO Finland
Foot and toes extensive X-ray examination
2.3
12.2
89
390
D07AB02
ATC
hydrocortisone butyrate; topical
1.4
12.2
739
5738
TND11
NOMESCO Finland
Injection of diagnostic or therapeutic substance in joint, wrist or hand
3.4
12.2
43
128
XJC00
NOMESCO Finland
Oesophageal manometry
5.5
12.1
23
42
R03AC03
ATC
terbutaline; inhalant
1.6
12.1
338
2264
J45.8
ICD-10 Finland
Mixed asthma
2.3
12.1
94
424
UDH02
NOMESCO Finland
Rhinopharyngoscopy
1.8
12.0
168
936
M33.9
ICD-10 Finland
Dermatopolymyositis, unspecified
18.1
12.0
18
10
WX740
NOMESCO Finland
Nitrogen oxide therapy
18.1
12.0
18
10
TGD00
NOMESCO Finland
Needle biopsy of lung
5.0
11.9
25
50
R70.0
ICD-10 Finland
Elevated erythrocyte sedimentation rate
2.3
11.9
89
394
R03BB01
ATC
ipratropium bromide; inhalant
1.8
11.9
167
933
81
HP
Angiography of the heart and coronary arteries
1.6
11.8
289
1877
WPB10
NOMESCO Finland
Making a convalescent care decision
5.9
11.8
21
36
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
1.6
11.8
313
2074
J10.0
ICD-10 Finland
Influenza with pneumonia, seasonal influenza virus identified
3.1
11.7
48
157
R03AC19
ATC
olodaterol
4.9
11.7
25
51
GDA98
NOMESCO Finland
Other bronchoscopic incision, excision of lesion or repair of lung
3.9
11.6
34
89
I20.81
ICD-10 Finland
Other angina pectoris stenosed coronary artery
1.5
11.6
352
2400
NG1DA
NOMESCO Finland
X-ray of knees
2.7
11.6
59
218
ZXX02
NOMESCO Finland
Extent of procedure, 2 units
3.4
11.5
41
123
U07.1
ICD-10 Finland
Emergency use of U07.1 | COVID-19, virus identified
1.5
11.4
348
2375
ZXA10
NOMESCO Finland
Bilateral
1.4
11.4
564
4226
C10AA01
ATC
simvastatin; oral
1.3
11.3
1524
13240
Z3229
NOMESCO Finland
Other healthcare associate professional
1.6
11.2
263
1691
XG404
NOMESCO Finland
Peak expiratory flow (PEF) measurement
4.5
11.2
27
61
NH3DA
NOMESCO Finland
Bilateral foot X-ray examination
2.7
11.0
58
218
C02KX04
ATC
macitentan; oral
43.5
10.9
13
*
A02BA02
ATC
ranitidine; systemic
1.4
10.9
601
4585
SPAT1263
SPAT
Sampling
1.3
10.9
1126
9432
J32.0
ICD-10 Finland
Chronic maxillary sinusitis
1.8
10.7
153
859
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
1.5
10.7
412
2948
XQ841
NOMESCO Finland
Examination of dermatosis with microscope
60.2
10.6
12
*
Z94.3
ICD-10 Finland
Heart and lungs transplant status
60.2
10.6
12
*
A49.9
ICD-10 Finland
Bacterial infection, unspecified
1.5
10.6
390
2765
R2130
NOMESCO Finland
Counselling and guidance which enhance independent living
1.6
10.6
234
1484
M33.2
ICD-10 Finland
Polymyositis
8.5
10.5
22
26
E84.9
ICD-10 Finland
Cystic fibrosis, unspecified
+∞
10.4
10
*
ZYC05
NOMESCO Finland
Non-real-time text-based remote communication
3.2
10.4
40
126
M13.9
ICD-10 Finland
Arthritis, unspecified
1.7
10.4
186
1116
J44.9
ICD-10 Finland
Chronic obstructive pulmonary disease, unspecified
1.7
10.4
192
1162
R01AD09
ATC
mometasone; nasal
1.3
10.4
951
7823
N05CF01
ATC
zopiclone; oral
1.3
10.3
941
7731
T86.8
ICD-10 Finland
Failure and rejection of other transplanted organs and tissues
32.6
10.3
13
*
C08CA02
ATC
felodipine; oral
1.5
10.3
347
2418
J10.1
ICD-10 Finland
Influenza with other respiratory manifestations, seasonal influenza virus identified
2.8
10.3
51
186
E0000UV, ,
ATC
1.3
10.2
1035
8623
I25.0
ICD-10 Finland
Atherosclerotic cardiovascular disease, so described
1.6
10.2
256
1674
WX302
NOMESCO Finland
Thoracal epidural anesthesy
1.8
10.2
152
866
Z50.9
ICD-10 Finland
Care involving use of rehabilitation procedure, unspecified
2.0
10.1
103
517
B01AC04
ATC
clopidogrel; oral
1.4
10.1
624
4842
R94.2
ICD-10 Finland
Abnormal results of pulmonary function studies
4.3
10.0
25
58
C08CA05
ATC
nifedipine; systemic
1.6
10.0
219
1384
K21.9
ICD-10 Finland
Gastro-oesophageal reflux disease without oesophagitis
1.6
10.0
247
1607
TFC10
NOMESCO Finland
Catheterisation of left atrium or ventricle
2.3
10.0
70
302
I27.0
ICD-10 Finland
Primary pulmonary hypertension
9.1
10.0
20
22
RS230, ,
NOMESCO Finland
4.6
10.0
23
50
213
Kela drug reimbursment
Fat metabolism disorder associated with chronic coronary artery disease
1.5
10.0
328
2273
JBC01
NOMESCO Finland
Laparoscopic gastro-oesophageal antireflux operation
2.7
9.9
53
201
ZXD10
NOMESCO Finland
Scheduled procedure
1.3
9.9
1052
8815
4040, ,
NOMESCO Finland
20.1
9.8
14
7
J70.2
ICD-10 Finland
Acute drug-induced interstitial lung disorders
8.7
9.8
20
23
J93.9
ICD-10 Finland
Pneumothorax, unspecified
4.0
9.8
27
68
R03AK04
ATC
salbutamol and sodium cromoglicate; inhalant
2.8
9.7
47
169
XF402
NOMESCO Finland
ECG with work load test
1.5
9.7
335
2343
UJF32
NOMESCO Finland
Coloscopy
1.3
9.7
768
6176
GD2SN
NOMESCO Finland
Lung ventilation SPECT
3.5
9.7
33
96
J01XB01
ATC
colistin; inhalant, parenteral
55.2
9.6
11
*
E84.0
ICD-10 Finland
Cystic fibrosis with pulmonary manifestations
55.2
9.6
11
*
A02BA03
ATC
famotidine; systemic
1.8
9.6
136
762
J01DB01
ATC
cefalexin; oral
1.3
9.6
2223
20489
I20.99
ICD-10 Finland
Angina pectoris, unspecified
1.5
9.6
261
1738
L01BB01, ,
ATC
11.4
9.5
17
15
RK250, ,
NOMESCO Finland
4.4
9.5
23
52
XQ800
NOMESCO Finland
Prick test
1.9
9.5
122
663
R05FB02
ATC
cough suppressants and expectorants; systemic
1.3
9.5
1038
8717
D20
ICPC
Mouth/tongue/lip symptom/complaint
1.9
9.5
112
593
J90
ICD-10 Finland
Pleural effusion, not elsewhere classified
1.8
9.4
133
745
WPA10
NOMESCO Finland
Proactive palliative care treatment plan
3.6
9.4
30
84
DM1AI
NOMESCO Finland
Cone beam CT of paranasal sinus
2.7
9.4
50
190
M01CB03
ATC
auranofin; oral
3.6
9.3
29
80
WX105
NOMESCO Finland
Surface analgesia on skin or mucosa
1.6
9.2
212
1357
XF600
NOMESCO Finland
Bloodpressure measurement
1.7
9.2
185
1146
R03AK10
ATC
vilanterol and fluticasone furoate; inhalant
2.0
9.2
103
536
S32.0
ICD-10 Finland
Fracture of lumbar vertebra
1.9
9.2
115
621
J20.5
ICD-10 Finland
Acute bronchitis due to respiratory syncytial virus
4.3
9.1
23
54
JC2AB
NOMESCO Finland
Oesophagus X-ray examination with contrast
3.0
9.1
38
126
TPH90
NOMESCO Finland
Removal of fixed intravenous catheter
3.0
9.1
38
126
J15.8
ICD-10 Finland
Other bacterial pneumonia
3.2
9.0
34
106
WX720
NOMESCO Finland
Own respiration
1.8
9.0
122
675
WX727
NOMESCO Finland
Estimation of exercise oxygen therapy
36.8
9.0
11
*
M35.8
ICD-10 Finland
Other specified systemic involvement of connective tissue
10.0
9.0
17
17
G30.1
ICD-10 Finland
Alzheimer disease with late onset
0.5
9.0
100
1829
J09
ICD-10 Finland
Influenza due to identified zoonotic or pandemic influenza virus
2.1
9.0
84
409
E000001, ,
ATC
1.4
8.9
475
3593
11
HP
Coronary artery bypass surgery
1.9
8.9
116
634
WX404
NOMESCO Finland
Intravenous generell anesthesy
1.4
8.9
462
3481
N03AX16
ATC
[U] pregabalin
1.3
8.9
603
4739
R03AC12
ATC
salmeterol; inhalant
1.7
8.9
148
872
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
1.4
8.8
460
3468
ZYY98
NOMESCO Finland
Missed treatment contact, no notification given by patient
8.6
8.8
18
21
J96.9
ICD-10 Finland
Respiratory failure, unspecified
3.4
8.8
30
88
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
1.3
8.7
1159
9948
M80.0
ICD-10 Finland
Postmenopausal osteoporosis with pathological fracture
2.2
8.7
68
309
R01AD08
ATC
fluticasone; nasal
1.3
8.6
586
4602
B37.0
ICD-10 Finland
Candidal stomatitis
3.2
8.6
33
104
TNH11
NOMESCO Finland
Injection of diagnostic or therapeutic substance in ankle joint or foot joint
3.3
8.6
32
99
M06
ICD-10 Finland
Other rheumatoid arthritis
4.0
8.6
24
61
AA3AI
NOMESCO Finland
Cone beam CT of facial bones
3.6
8.6
27
75
ZXE13
NOMESCO Finland
Procedure duration 90 to 119 minutes
2.3
8.5
64
286
R01AD12
ATC
fluticasone furoate; nasal
1.3
8.5
540
4200
FXF00
NOMESCO Finland
Decannulation after ECHLA or ECLA
27.6
8.5
11
*
Z03.5
ICD-10 Finland
Observation for other suspected cardiovascular diseases
1.6
8.5
199
1281
Z95.1
ICD-10 Finland
Presence of aortocoronary bypass graft
1.6
8.5
193
1234
ECB20
NOMESCO Finland
Oral alveoplasty
2.9
8.4
38
132
5169X
ICD-9 Finland
Other alveolar and parietoalveolar pneumopathy, Unspecified alveolar and parietoalveolar pneumopathy
+∞
8.3
8
*
304
Kela drug reimbursment
Dornase alfa
+∞
8.3
8
*
R05CB13
ATC
dornase alfa (desoxyribonuclease); inhalant
+∞
8.3
8
*
4038, ,
NOMESCO Finland
+∞
8.3
8
*
K23.8*B37.8
ICD-10 Finland
Esophagitis caused by candidiasis
4.0
8.3
23
58
J98.4
ICD-10 Finland
Other disorders of lung
8.5
8.3
17
20
R03AL03
ATC
vilanterol and umeclidinium bromide; inhalant
2.6
8.2
47
185
I71.4
ICD-10 Finland
Abdominal aortic aneurysm, without mention of rupture
1.8
8.2
110
607
JN4AD
NOMESCO Finland
Body CT examination
1.5
8.2
302
2139
ZXE04
NOMESCO Finland
Procedure duration 30 to 39 minutes
1.7
8.2
147
884
ZXX01
NOMESCO Finland
Extent of proceudre, 1 unit
4.4
8.1
20
46
K52.88
ICD-10 Finland
Other specified noninfective gastroenteritis and colitis
2.3
8.1
60
266
N05AX08
ATC
risperidone; systemic
0.5
8.1
100
1774
TGE00
NOMESCO Finland
Needle biopsy of mediastinum
4.5
8.1
19
42
C02KX01
ATC
bosentan; oral
33.4
8.1
10
*
J99.1*M33.2
ICD-10 Finland
Respiratory disorders in polymyositis
33.4
8.1
10
*
L04AB04
ATC
adalimumab; parenteral
3.0
8.1
35
119
M80.8
ICD-10 Finland
Other osteoporosis with pathological fracture
4.0
8.1
22
55
R2110
NOMESCO Finland
Giving the first information
1.7
8.0
134
790
J98.9
ICD-10 Finland
Respiratory disorder, unspecified
8.9
8.0
16
18
DM1AD
NOMESCO Finland
CT of paranasal sinuses and face area
2.0
8.0
81
407
J18
ICD-10 Finland
Pneumonia, organism unspecified
3.0
8.0
33
109
N02AJ06
ATC
codeine and paracetamol; systemic
1.3
8.0
972
8232
M05BA06
ATC
ibandronic acid; systemic
2.2
8.0
62
281
N03AX12
ATC
[U] gabapentin; oral
1.4
8.0
401
3003
L95
ICPC
Osteoporosis
1.9
7.9
100
542
R03AC13
ATC
formoterol; inhalant
1.7
7.9
137
817
R03AK11
ATC
formoterol and fluticasone; inhalant
2.2
7.8
64
296
J93.0
ICD-10 Finland
Spontaneous tension pneumothorax
8.5
7.8
16
19
3006
Kela drug reimbursment
Baricitinib
10.8
7.8
14
13
FN1CD
NOMESCO Finland
Very extensive CT of coronary arteries
4.2
7.7
20
48
H26.3
ICD-10 Finland
Drug-induced cataract
3.9
7.7
22
57
JN4BD
NOMESCO Finland
Extensive body CT
1.4
7.7
321
2328
ZX100
NOMESCO Finland
Oral
2.4
7.7
51
216
L01CB
ATC
Podophyllotoxin derivatives
7.4
7.7
17
23
WPA11
NOMESCO Finland
Developing a plan for palliative care
7.4
7.7
17
23
H05BA01
ATC
calcitonin (salmon synthetic); nasal, parenteral
1.8
7.6
120
697
R06.8
ICD-10 Finland
Other and unspecified abnormalities of breathing
2.6
7.6
43
169
XF614
NOMESCO Finland
Measurement of pulmonary artery pressure
8.0
7.6
16
20
L04AC07
ATC
tocilizumab; parenteral
11.9
7.6
13
11
I70.2
ICD-10 Finland
Atherosclerosis of arteries of extremities
1.4
7.6
361
2680
D07AC13
ATC
mometasone; topical
1.3
7.6
710
5819
FNA01
NOMESCO Finland
Anastomosis to coronary artery from internal mammary artery, one distal anastamosis
1.5
7.5
199
1317
E03.9
ICD-10 Finland
Hypothyroidism, unspecified
1.4
7.5
288
2056
C09AA05
ATC
ramipril; oral
1.3
7.5
864
7259
R04
ICPC
Breathing problem other
1.9
7.5
92
495
TGW99
NOMESCO Finland
Other minor procedure in thoracic surgery
7.1
7.5
17
24
XF655
NOMESCO Finland
Measurement of heart muscle perfusion with exercise
1.8
7.4
98
539
WZC00
NOMESCO Finland
Treatment plan or consultation
1.3
7.4
855
7181
F03
ICD-10 Finland
Unspecified dementia
0.5
7.4
56
1162
WZC10
NOMESCO Finland
Written specialist consultation based on a referral from a dentist or a physician
1.8
7.4
109
620
J02AC03
ATC
voriconazole; systemic
7.7
7.4
16
21
GD1UN
NOMESCO Finland
Lung circulation SPECT
3.3
7.4
27
83
N06DA03
ATC
rivastigmine; oral, transdermal
0.5
7.4
56
1158
J42
ICD-10 Finland
Unspecified chronic bronchitis
2.5
7.3
43
172
2770A
ICD-9 Finland
Other and unspecified disorders of metabolism, Cystic fibrosis
+∞
7.3
7
*
293
Kela drug reimbursment
Baricitinib
10.9
7.3
13
12
M05BX04
ATC
denosumab; parenteral
1.6
7.3
177
1150
B25.9
ICD-10 Finland
Cytomegaloviral disease, unspecified
9.4
7.3
14
15
N02BE01
ATC
paracetamol; systemic, rectal
1.3
7.2
2496
23625
J01GB01
ATC
tobramycin; inhalant, parenteral
15.8
7.2
11
7
GD5CD
NOMESCO Finland
Thorax and upper abdomen combined very extensive CT examination of
3.7
7.2
22
60
R04.0
ICD-10 Finland
Epistaxis
1.5
7.2
248
1737
E66.8
ICD-10 Finland
Other obesity
1.9
7.2
80
417
R06AX22
ATC
ebastine; oral
1.4
7.1
303
2205
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
1.5
7.1
190
1261
FN1YT
NOMESCO Finland
Percutaneous insertion of coronary artery stent
1.5
7.1
212
1441
A28
ICPC
Limited function/disability NOS
1.3
7.1
622
5051
XF622
NOMESCO Finland
Measurement of minute volume of heart
5.6
7.1
19
34
C61
ICD-10 Finland
Malignant neoplasm of prostate
0.7
7.0
230
3250
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
1.4
7.0
304
2218
L04AA37
ATC
[U] baricitinib
10.0
7.0
13
13
WZB00
NOMESCO Finland
Telephone prescription or other care instructions
1.3
7.0
585
4716
WPA13
NOMESCO Finland
Palliative consultation
4.2
7.0
18
43
ZXE50
NOMESCO Finland
More than nine and less than 12 hours
2.3
7.0
49
213
XA421
NOMESCO Finland
Nocturnal polygraphy
6.3
6.9
17
27
XG480
NOMESCO Finland
Histamine provocation of respiratroy tract
3.0
6.9
29
97
ZXE10
NOMESCO Finland
More than one and less than three hours
1.2
6.9
972
8340
R01AD58
ATC
fluticasone, combinations; nasal
1.4
6.9
368
2781
J05AB11
ATC
valaciclovir; oral
1.4
6.9
322
2381
WX723
NOMESCO Finland
CPAP therapy
1.9
6.9
77
402
R03DA04
ATC
theophylline; systemic, rectal
1.5
6.9
186
1239
I25.2
ICD-10 Finland
Old myocardial infarction
1.4
6.8
284
2058
B02.9
ICD-10 Finland
Zoster without complication
1.5
6.8
184
1225
ZX121
NOMESCO Finland
Central venous catheter
6.7
6.8
16
24
XX6XT
NOMESCO Finland
Other intravascular therapy with radiological guidance
6.7
6.8
16
24
NA1EA
NOMESCO Finland
Cervical spine X-ray examination with flexion
2.6
6.8
36
137
B44.1
ICD-10 Finland
Other pulmonary aspergillosis
10.9
6.8
12
11
R05FA02
ATC
opium derivatives and expectorants; systemic
1.2
6.8
981
8439
M80.9
ICD-10 Finland
Unspecified osteoporosis with pathological fracture
2.0
6.8
66
328
D07AB08
ATC
desonide; topical
1.4
6.8
253
1799
NH3FA
NOMESCO Finland
Weight-bearing X-ray of foot
2.4
6.8
42
173
FN1AT
NOMESCO Finland
Endovascular dilatation of coronary arteries (PTCA)
1.5
6.8
184
1227
FXE00
NOMESCO Finland
Use of ECLA
40.1
6.8
8
*
B07.9
ICD-10 Finland
Verruca simplex
2.0
6.8
69
349
WPA15
NOMESCO Finland
Palliative care consultation with the patient and loved ones
4.3
6.7
17
40
8140/3-C61.9
ICD-O-3
Adenocarcinoma, NOS, of prostate gland
0.7
6.7
213
3027
J98.6
ICD-10 Finland
Disorders of diaphragm
3.9
6.7
19
49
J12.1
ICD-10 Finland
Respiratory syncytial virus pneumonia
3.4
6.7
23
68
1240
FHL
Bronchoscopy
2.4
6.7
43
180
N07BA03
ATC
varenicline; oral
1.9
6.7
75
392
NDG30
NOMESCO Finland
Fusion of wrist, total
4.0
6.6
18
45
C34.32
ICD-10 Finland
Malignant tumor of the lower lobe, bronchus or lung adenocarcinoma
2.7
6.6
33
122
K57.3
ICD-10 Finland
Diverticular disease of large intestine without perforation or abscess
1.3
6.6
553
4460
K03.82
ICD-10 Finland
Split tooth for reasons other than trauma
0.7
6.6
274
3711
K31.8
ICD-10 Finland
Other specified diseases of stomach and duodenum
3.5
6.6
22
64
ZY000
NOMESCO Finland
Hospital inpatient
3.3
6.5
24
74
XG467
NOMESCO Finland
Nocturnal CO2 monitoring
10.0
6.5
12
12
NHG76
NOMESCO Finland
Arthroplasty of other tarsometatarsal joint
2.4
6.5
41
170
N06DX01
ATC
memantine; oral
0.6
6.5
156
2343
FN1BC
NOMESCO Finland
Extensive angiography of hear and/or coronary arteries
1.5
6.5
177
1182
R79
ICPC
Chronic bronchitis
6.2
6.5
16
26
X59
ICD-10 Finland
Exposure to unspecified factor
1.3
6.4
435
3405
D06BB04
ATC
podophyllotoxin; topical
2.2
6.4
53
247
M05BX03
ATC
strontium ranelate; oral
3.5
6.4
21
60
J99.1*M32.1
ICD-10 Finland
Respiratory disorders in systemic: lupus erythematosus
70.0
6.4
7
*
7102A
ICD-9 Finland
Diffuse diseases of connective tissue, Sicca syndrome[SYNDROMA SICCUM PRIMARIUM]
70.0
6.4
7
*
S22.2
ICD-10 Finland
Fracture of sternum
3.2
6.4
24
75
NCB20
NOMESCO Finland
Primary total prosthetic replacement of elbow joint
14.3
6.4
10
7
SAA03
NOMESCO Finland
Extended examination of mouth
1.2
6.3
785
6631
J99.1*M31.3
ICD-10 Finland
Respiratory disorders in Wegener's granulomatosis
11.0
6.3
11
10
D80.1
ICD-10 Finland
Nonfamilial hypogammaglobulinaemia
9.3
6.3
12
13
B90.9
ICD-10 Finland
Sequelae of respiratory and unspecified tuberculosis
3.3
6.3
23
71
E27.3
ICD-10 Finland
Drug-induced adrenocortical insufficiency
3.8
6.3
18
47
J67.8
ICD-10 Finland
Hypersensitivity pneumonitis due to other organic dusts
26.7
6.2
8
*
M05BB04
ATC
risedronic acid, calcium and colecalciferol, sequential; oral
7.0
6.2
14
20
SPAT1256
SPAT
Intramuscular and subcutaneous injection
1.2
6.2
1130
9933
Z71.3
ICD-10 Finland
Dietary counselling and surveillance
1.8
6.2
91
519
TPH40
NOMESCO Finland
Insertion of a long peripheral venous catheter
3.7
6.2
19
52
TNG11
NOMESCO Finland
Injection of diagnostic or therapeutic substance in knee
3.1
6.2
25
82
M06.8
ICD-10 Finland
Other specified rheumatoid arthritis
3.1
6.2
24
77
NB1AA
NOMESCO Finland
Shoulder X-ray examination without contrast
1.5
6.2
182
1236
RS220, ,
NOMESCO Finland
2.7
6.1
32
121
XG422
NOMESCO Finland
Time-volume spirometry with bronchodialtation
7.7
6.1
13
17
L04AA17
ATC
[U] adalimumab
7.7
6.1
13
17
J18.1
ICD-10 Finland
Lobar pneumonia, unspecified
2.4
6.1
39
163
WX000
NOMESCO Finland
Monitoring vital functions without anesthesy
1.7
6.1
100
590
307
Kela drug reimbursment
Tacrine, donepezil, rivastigmine, galantamine and other major and expensive drugs used to treat Alzheimer's disease
0.5
6.1
60
1133
RK310, ,
NOMESCO Finland
8.6
6.0
12
14
Z03.9
ICD-10 Finland
Observation for suspected disease or condition, unspecified
1.3
6.0
447
3543
R07.4
ICD-10 Finland
Chest pain, unspecified
1.2
6.0
771
6530
I20.09
ICD-10 Finland
Unstable angina
1.5
6.0
204
1424
B01AC06
ATC
acetylsalicylic acid; oral
1.6
6.0
150
982

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
1133
2431
6.79
307.65
1.5
1.3
621.25
529.66
titre
0.73
369
522
818
1985
5.25
307.65
4.2
4.6
—
—
—
0
0
256
71
39.23
307.65
1.1
1.1
—
—
—
0
0
608
983
7.46
307.65
1.4
1.6
13.27
17.37
u/ml
—
9
29
399
404
11.19
307.65
2.8
2.4
—
—
—
0
0
1035
3188
4.38
302.45
1.4
1.2
72.51
36.96
iu/ml
4.73
371
984
413
621
7.52
267.52
1.2
1.2
1.04
0.56
u/ml
0.42
45
54
460
780
6.76
266.11
1.7
1.6
276.06
196.50
titre
0.34
33
40
1013
3416
3.93
255.40
8.7
6.7
5.05
5.07
kpa
0.24
968
3229
1012
3416
3.92
254.69
8.7
6.7
9.78
11.84
kpa
48.56
969
3231
2075
11119
3.65
251.11
13.2
5.9
—
—
—
0
0
1004
3416
3.87
249.06
8.8
6.7
1.68
1.11
mmol/l
4.33
837
2649
2143
11833
3.66
244.65
11.5
5.3
0.69
0.63
e9/l
14.95
1983
9992
2146
11880
3.65
243.53
11.5
5.3
0.04
0.04
e9/l
5.25
1984
10040
925
3025
3.94
242.29
1.3
1.2
31.78
14.99
u/ml
1.39
247
1050
2181
12250
3.66
240.62
12.3
5.5
0.22
0.20
e9/l
7.37
2033
10484
402
657
6.89
240.21
2.5
2.2
130.91
126.75
g/l
1.32
157
495
2017
10885
3.46
235.44
12.1
5.6
0.61
0.65
%
1.86
1971
10000
2148
12115
3.55
231.67
11.8
5.4
1.89
1.86
e9/l
0.29
2003
10471
668
1790
4.49
228.84
3.2
1.5
—
—
—
0
0
647
1694
4.57
228.35
2.1
1.4
—
—
—
0
0
2032
11208
3.38
224.63
12.3
5.6
2.82
2.87
%
0.51
1988
10310
2035
11255
3.37
223.50
12.8
6.0
8.83
9.00
%
1.74
1987
10361
2038
11447
3.30
214.56
12.5
5.8
24.20
25.69
%
7.90
1990
10560
2013
11253
3.27
213.11
12.0
5.6
60.75
58.79
%
10.25
1965
10379
291
384
8.26
210.11
1.3
1.2
27.27
2.26
u/ml
1.54
32
26
315
459
7.53
208.64
1.3
1.2
2.68
3.72
u/ml
0.47
45
43
317
466
7.47
208.30
1.3
1.2
9.21
6.95
u/ml
0.23
69
71
366
628
6.48
207.73
1.7
1.4
13.24
16.23
iu/ml
0.14
21
13
322
491
7.21
204.56
1.3
1.2
26.25
43.56
u/ml
0.44
15
23
601
1615
4.38
203.58
4.0
2.7
10.59
10.72
g/l
0.24
573
1452
296
488
6.60
174.03
1.3
1.2
73.85
121.67
titre
0.39
13
12
828
3108
3.27
168.13
9.6
6.9
93.31
95.26
%
11.62
798
2976
2188
13873
2.99
165.88
14.4
8.4
4.98
4.35
e9/l
23.80
2045
11939
481
1283
4.26
162.56
2.3
1.9
1.07
1.50
g/l
3.60
449
1144
246
358
7.38
162.42
1.4
1.3
—
—
—
0
0
103
35
30.41
156.22
4.1
5.0
—
—
—
0
0
528
1571
3.85
152.77
10.9
8.4
24.93
24.25
mmol/l
4.40
503
1508
106
43
25.49
151.28
1.1
1.1
—
—
—
0
0
106
43
25.49
151.28
1.1
1.1
—
—
—
0
0
106
43
25.49
151.28
1.1
1.1
—
—
—
0
0
248
400
6.65
148.54
3.0
2.6
—
—
—
0
0
265
522
5.46
128.74
1.7
1.4
0.22
0.24
g/l
2.03
255
493
216
357
6.43
126.03
1.3
1.3
—
—
—
0
0
90
39
23.74
125.14
1.0
1.0
—
—
—
0
0
90
39
23.74
125.14
1.0
1.1
—
—
—
0
0
268
547
5.27
125.04
1.7
1.4
1.19
1.16
g/l
0.74
260
515
197
306
6.81
122.00
1.3
1.4
139.09
128.90
u/ml
0.11
37
59
211
355
6.31
120.89
1.3
1.3
43.00
15.26
u/ml
—
6
8
167
221
7.93
119.43
1.2
1.1
119.01
112.85
%
1.26
161
203
161
204
8.27
119.42
1.3
1.2
49.97
57.53
u/ml
—
15
10
1305
7182
2.42
118.73
6.1
3.0
31.80
36.68
u/l
2.27
1259
6789
113
91
12.85
115.84
3.9
1.8
32.76
62.22
ug/l
2.88
113
86
176
259
7.15
114.55
1.3
1.2
—
—
—
0
0
91
52
18.00
112.28
3.4
1.2
—
—
—
0
0
253
540
5.01
111.87
1.5
1.8
10.40
13.37
mg/l
2.43
233
490
662
2696
2.85
111.65
2.9
1.4
—
—
—
0
0
1999
13485
2.37
110.41
11.1
6.0
11.47
12.54
umol/l
3.48
1954
12765
1441
8490
2.31
109.58
5.4
4.3
—
—
—
0
0
359
1023
3.84
108.92
1.6
1.2
245.40
225.28
u/ml
0.15
331
928
1564
9553
2.29
108.88
4.4
3.2
1651.45
1923.49
ng/l
1.68
1430
8314
190
321
6.24
108.27
1.3
1.2
60.20
45.67
u/ml
0.41
28
28
142
174
8.51
108.18
1.1
1.1
97.65
93.25
%
0.95
137
165
556
2113
2.99
106.03
6.0
3.9
0.79
0.92
%
0.70
253
786
77
35
22.54
104.96
1.2
1.6
—
—
—
0
0
667
2809
2.75
104.90
11.2
7.4
126.40
120.08
g/l
11.07
651
2730
162
240
7.07
104.71
1.2
1.2
3.55
5.61
u/ml
0.76
97
109
516
1897
3.07
104.24
7.4
6.6
25.13
24.44
mmol/l
3.56
498
1800
516
1900
3.06
103.93
5.7
3.8
0.55
0.77
%
1.68
226
667
101
83
12.55
102.19
48.7
24.4
172.05
105.37
ug/l
9.38
84
69
128
156
8.52
97.89
1.4
1.2
3.19
2.93
g/l
0.63
92
112
128
156
8.52
97.89
1.4
1.2
7.85
6.85
g/l
1.24
88
110
128
156
8.52
97.89
1.4
1.2
0.55
0.40
g/l
2.60
92
111
128
159
8.36
96.37
1.4
1.2
—
—
—
0
0
118
140
8.72
92.17
1.1
1.1
—
—
—
0
0
489
1874
2.91
90.93
5.9
3.9
0.05
0.29
%
0.87
185
559
507
2006
2.83
88.70
6.0
3.9
0.08
0.11
%
0.42
204
683
527
2131
2.78
88.43
1.5
1.5
—
—
—
0
0
157
270
6.07
87.70
1.6
1.6
0.93
0.90
g/l
0.09
116
208
495
1949
2.83
87.31
6.8
3.6
5.23
5.15
kpa
1.11
483
1820
488
1921
2.83
86.03
6.8
3.6
7.43
7.41
ph
3.81
78
232
249
654
4.05
84.17
3.2
2.3
3.90
3.63
g/l
1.80
241
614
1796
12404
2.07
82.40
9.4
6.0
1.20
1.21
mmol/l
5.84
1692
11179
77
59
13.36
81.17
42.5
32.6
8.28
6.71
ug/l
5.48
68
54
931
5060
2.20
80.68
2.6
1.6
1.76
1.52
mg/l
0.69
767
3951
2311
17755
2.20
77.15
9.8
4.1
19.31
14.42
mm/h
32.22
2245
16135
111
152
7.54
76.86
2.2
2.3
—
—
—
0
0
187
424
4.63
76.47
4.2
3.0
4.89
4.49
e9/l
1.32
187
424
191
441
4.55
76.36
4.4
3.4
59.91
59.18
%
0.30
191
441
1294
8096
2.03
76.22
5.1
4.0
7.40
7.40
ph
0.73
285
1529
375
1362
3.00
76.16
2.3
1.9
1.23
2.43
ug/l
1.47
341
1173
108
146
7.63
75.63
1.1
1.2
—
—
—
0
0
327
1118
3.15
73.68
1.3
1.3
—
—
—
0
0
270
828
3.48
72.56
5.3
3.0
25.98
24.91
mmol/l
3.56
265
810
68
51
13.61
72.55
1.1
1.4
—
—
—
0
0
1892
13665
1.99
72.38
10.3
6.8
1.20
1.21
mmol/l
3.02
1614
11511
236
668
3.74
71.55
5.9
3.9
—
—
—
0
0
107
153
7.21
71.28
2.3
2.3
—
—
—
0
0
148
292
5.27
71.27
1.1
1.2
349.36
277.37
u/ml
1.34
107
167
610
2930
2.35
69.93
4.6
3.0
224.86
258.61
ng/l
1.04
577
2685
219
612
3.78
67.58
5.1
2.7
—
—
—
0
0
700
3611
2.21
67.40
2.0
1.5
2.97
2.76
g/l
1.47
515
2025
73
71
10.51
66.01
3.5
1.3
—
—
—
0
0
1508
10295
1.91
65.78
18.9
10.3
0.00
0.00
e9/l
0.54
1308
8318
91
119
7.85
65.53
1.3
1.2
—
—
—
0
0
254
828
3.25
61.69
3.5
1.9
21.78
21.74
s
0.02
235
755
430
1877
2.50
60.34
1.5
1.5
—
—
—
0
0
417
1796
2.53
60.20
1.5
1.5
—
—
—
0
0
383
1593
2.60
59.42
15.7
9.0
—
—
—
0
0
163
406
4.18
58.94
1.1
1.2
—
—
—
0
0
214
648
3.47
58.42
3.8
2.4
15.70
15.74
%
0.06
127
329
554
2754
2.23
57.54
12.6
6.5
10.03
11.52
mmol/l
5.34
524
2599
778
4414
2.02
57.07
8.3
2.9
0.80
0.82
mmol/l
3.16
723
4083
989
6106
1.91
56.55
10.6
6.4
—
—
—
0
0
696
3816
2.06
55.98
2.9
2.0
—
—
—
0
0
680
3709
2.07
55.40
12.3
6.4
103.92
104.32
mmol/l
1.33
680
3704
2366
19259
1.98
54.78
14.8
7.5
78.30
81.73
u/l
2.85
2314
17968
332
1381
2.57
51.19
7.1
3.8
—
—
—
0
0
97
182
5.47
49.32
2.7
2.5
7.43
7.42
ph
0.17
68
55
97
185
5.38
48.45
1.7
2.1
1.04
1.12
e9/l
0.29
88
169
94
176
5.48
47.91
1.3
1.1
—
—
—
0
0
248
934
2.80
46.43
7.1
6.1
1.45
1.34
mmol/l
0.89
230
829
47
40
11.92
46.35
1.1
1.1
—
—
—
0
0
102
213
4.92
45.96
1.3
1.5
—
1588.57
—
0
7
303
1277
2.52
45.27
5.1
5.1
1.84
1.59
%
4.44
287
1200
888
5631
1.81
44.63
5.2
4.1
566.04
592.29
ng/l
0.05
804
4934
195
657
3.10
44.59
8.5
4.8
3.13
2.70
mmol/l
1.20
154
438
1583
11860
1.69
43.29
6.0
4.7
33.10
34.47
g/l
17.60
1475
10912
1211
8529
1.69
41.21
5.3
3.5
41.50
108.07
e6/l
2.88
1010
6735
1083
7425
1.71
40.59
5.0
3.4
—
—
—
0
0
477
2540
2.04
40.32
2.0
2.1
0.21
0.20
g/l
2.69
449
2337
209
774
2.82
40.30
8.4
4.5
7.42
7.42
ph
0.92
192
691
69
116
6.06
39.37
1.6
1.3
0.79
2.33
u/ml
0.83
45
62
105
256
4.21
39.02
1.2
1.2
190.09
199.74
miu/ml
0.07
11
73
886
5803
1.74
38.87
4.3
3.1
546.39
550.35
mosm/kgh2o
0.25
798
4981
1112
7747
1.68
38.84
5.1
3.4
0.40
0.51
e6/l
1.13
917
6055
1775
13952
1.64
38.23
19.8
20.2
1.35
1.41
inr
2.05
558
3889
1940
15594
1.66
38.23
9.2
4.9
6.86
6.93
mmol/l
0.87
1859
14703
1174
8339
1.66
37.78
4.0
2.2
137.25
233.08
u/l
5.06
1101
7745
57
82
7.06
37.73
1.1
1.2
1.04
1.06
ratio
0.22
19
26
475
2598
1.98
37.01
12.2
6.3
1.41
1.41
mmol/l
0.03
452
2525
1305
9566
1.63
36.77
6.4
4.0
137.39
119.23
e6/l
0.16
1034
7139
910
6085
1.70
36.62
4.0
2.7
4.02
4.44
e6/l
0.63
838
5480
456
2472
1.99
36.41
13.4
7.4
—
—
—
0
0
267
1187
2.37
35.26
5.3
4.4
—
—
—
0
0
47
63
7.56
33.11
1.1
1.1
4.50
11.83
u/ml
—
8
6
175
659
2.76
32.63
6.4
7.0
11.73
11.23
mmol/l
1.20
161
589
175
659
2.76
32.63
6.4
7.0
103.87
105.25
mmol/l
3.70
161
589
378
1990
2.03
32.57
1.9
2.1
360.25
373.75
nmol/l
0.40
356
1781
269
1259
2.25
31.41
5.6
5.1
0.89
0.88
%
0.32
252
1183
491
2861
1.85
31.19
4.4
3.5
2.41
1.93
mmol/l
1.80
418
2363
664
4246
1.72
30.67
2.4
2.5
2.24
2.25
g/l
0.10
618
3899
2056
17199
1.59
30.52
7.0
4.6
—
—
—
0
0
490
2874
1.84
30.42
4.4
3.5
5.91
5.82
kpa
0.93
468
2776
352
1853
2.02
30.24
15.6
8.1
1.42
1.32
%
1.72
346
1839
62
123
5.12
29.67
1.7
2.0
0.20
0.22
e9/l
0.19
54
110
698
4560
1.69
29.65
2.5
2.5
11.60
12.21
umol/l
1.62
662
4214
348
1841
2.00
29.45
15.9
8.2
0.63
0.66
%
0.65
342
1827
63
128
5.00
29.34
1.7
2.1
442.19
536.04
e6/l
0.47
53
112
633
4040
1.71
29.28
2.5
2.6
20.97
22.01
%
1.12
524
3414
598
3775
1.72
28.73
7.4
5.6
1.04
1.04
mmol/l
0.02
551
3470
907
6417
1.59
27.65
6.5
4.0
83.75
82.81
%
0.49
891
6256
230
1065
2.25
27.50
4.4
3.7
1.36
1.43
mmol/l
0.56
225
1045
38
50
7.68
27.19
1.3
1.5
—
—
—
0
0
1262
9686
1.51
26.24
2.9
2.2
76.19
79.02
nmol/l
3.17
1158
8339
241
1165
2.16
25.88
8.2
4.0
25.20
24.75
mmol/l
1.66
230
1052
1390
10931
1.49
25.43
5.3
4.3
162.81
57.50
ng/l
0.42
1140
8582
1493
11920
1.49
25.29
5.1
4.0
0.00
0.00
estimate
1.34
395
2435
44
75
5.94
24.79
1.7
2.2
—
—
—
0
0
1481
11868
1.48
24.24
7.0
5.3
0.00
0.00
estimate
0.50
377
2237
955
6999
1.53
24.22
5.7
2.9
1013.73
6639.44
umol/l
9.13
840
5917
34
45
7.63
24.21
1.0
1.1
—
—
—
0
0
1496
12040
1.47
23.78
5.1
4.0
0.00
0.00
estimate
0.80
364
2167
663
4509
1.60
23.28
4.5
3.2
1.51
1.75
e6/l
0.61
409
2592
1984
16966
1.47
22.45
6.7
5.1
506.85
1687.64
e6/l
1.18
34
322
430
2646
1.73
22.19
2.0
2.5
66.42
65.97
g/l
0.53
389
2376
451
2828
1.70
21.70
2.5
2.7
9.86
10.04
umol/l
0.05
393
2498
33
48
6.94
21.64
1.0
1.1
—
—
—
0
0
260
1396
1.94
20.88
3.8
3.6
24.59
24.05
mmol/l
1.79
252
1350
368
2203
1.76
20.87
1.9
2.4
—
—
—
0
0
39
70
5.63
20.85
1.1
1.2
—
—
—
0
0
652
4521
1.56
20.76
2.9
1.9
29.86
30.23
s
0.89
635
4367
210
1059
2.05
20.14
4.3
2.2
316.54
532.16
ug/l
1.74
200
999
1042
8024
1.45
19.75
2.9
2.5
60.72
70.06
u/l
0.44
974
7346
36
65
5.59
19.14
1.6
1.8
19.11
148.96
ug/l
0.52
36
56
30
19
15.94
18.77
1.7
1.6
—
—
—
0
0
370
2283
1.71
18.75
4.0
3.9
1.21
1.22
mmol/l
1.88
338
1986
56
150
3.78
18.41
1.1
1.2
89.00
123.33
titre
—
10
27
1145
9083
1.41
18.00
4.2
3.3
2.34
2.35
mmol/l
1.71
1037
7761
145
663
2.25
17.86
1.3
1.4
—
—
—
0
0
554
3829
1.54
17.59
2.7
2.3
1.88
1.76
%
2.07
479
3326
663
4803
1.48
16.75
4.2
3.0
0.84
1.23
e6/l
3.06
415
2850
2161
19217
1.42
16.68
36.5
20.9
15.31
15.43
%
0.50
2145
18813
372
2375
1.64
16.46
3.9
2.9
4.49
4.45
kpa
0.13
352
2284
434
2881
1.59
16.37
2.6
2.4
69.03
67.44
e9/l
0.40
306
2218
332
2070
1.68
16.09
5.4
4.3
—
—
—
0
0
1170
9488
1.38
15.48
4.3
3.7
5.96
5.81
ph
0.42
26
357
117
522
2.29
15.31
1.3
1.2
—
—
—
0
0
804
6139
1.42
15.14
5.1
3.8
—
—
—
0
0
1191
9749
1.36
14.61
3.0
2.8
192.01
162.68
ug/l
2.60
1080
8779
258
1560
1.71
13.98
4.6
3.3
25.75
25.02
mmol/l
2.21
245
1515
159
828
1.97
13.96
3.8
3.4
—
—
—
0
0
28
54
5.22
13.90
1.0
1.0
—
—
—
0
0
476
3360
1.49
13.39
1.3
1.3
—
—
—
0
0
930
7427
1.36
13.00
2.4
2.3
3.19
3.08
mg/l
0.63
813
6246
293
1869
1.63
12.93
4.2
3.1
127.61
126.82
g/l
0.24
283
1822
44
129
3.45
12.75
2.1
2.6
40.65
37.16
%
0.52
26
78
186
1055
1.81
12.58
2.5
3.3
72.35
61.11
mg/l
0.44
141
876
185
1053
1.81
12.37
2.5
3.3
37.04
68.08
mg/l
1.56
139
880
107
508
2.15
12.10
4.2
3.8
1.31
1.66
%
0.52
99
433
148
795
1.91
11.89
2.3
3.5
—
—
—
0
0
108
528
2.08
11.34
1.1
1.1
127.27
91.56
titre
0.29
11
32
69
280
2.50
11.23
1.1
1.1
1.59
1.56
g/l
0.25
58
252
177
1029
1.76
11.04
2.5
3.3
6.38
2.54
ratio
0.68
13
77
738
5811
1.35
10.98
4.3
3.9
—
—
—
0
0
2491
23210
1.38
10.94
33.8
17.8
25.75
28.05
mg/l
3.44
2348
19149
426
3068
1.45
10.69
2.1
1.8
—
—
—
0
0
1912
17182
1.30
10.64
6.1
4.4
—
—
—
0
0
1556
13619
1.29
10.63
4.7
3.1
66.01
57.27
u/l
1.75
1449
12316
826
6657
1.33
10.43
5.4
4.4
0.00
0.00
estimate
0.88
347
2093
187
1132
1.69
10.11
2.1
2.4
3.09
2.99
g/l
0.83
170
996
131
723
1.85
9.73
1.5
1.5
—
—
—
0
0
1037
8688
1.29
9.71
3.9
3.5
—
—
—
0
0
48
177
2.74
9.51
1.6
2.1
—
—
—
0
0
49
183
2.70
9.47
2.4
2.9
7.37
7.10
mmol/l
0.31
43
119
51
195
2.64
9.42
1.3
1.2
—
—
—
0
0
96
483
2.02
9.39
1.6
1.5
—
—
—
0
0
197
1235
1.64
9.33
2.1
2.4
4.02
3.67
g/l
1.99
179
1099
197
1237
1.63
9.27
2.1
2.4
8.06
7.40
g/l
5.26
180
1099
16
15
10.72
8.78
1.0
1.1
—
—
—
0
0
231
1535
1.55
8.56
3.2
3.4
5.20
5.39
e9/l
0.10
195
1118
214
1404
1.56
8.40
3.4
2.5
0.68
0.64
%
0.56
214
1396
101
539
1.90
8.37
1.1
1.1
1192.00
1229.41
titre
—
5
17
42
156
2.72
8.25
1.5
1.2
—
—
—
0
0
42
156
2.72
8.25
6.3
3.5
—
—
—
0
0
20
31
6.49
8.17
1.6
2.1
2212.00
200.00
e6/l
—
10
8
183
1169
1.60
8.06
2.1
2.4
10.63
10.36
g/l
0.39
165
1023
80
400
2.03
8.01
7.8
6.2
12.10
12.54
mg/l
0.41
75
366
112
632
1.80
7.81
2.5
2.7
1.82
1.78
mg/l
0.19
98
555
106
590
1.82
7.73
2.1
2.3
30.39
33.26
umol/l
0.55
99
510
65
312
2.11
7.29
1.5
1.5
55.54
65.95
%
1.18
37
196
229
1576
1.49
7.22
1.8
1.7
1.66
1.52
g/l
1.25
186
1333
19
33
5.79
7.21
1.1
1.2
—
—
—
0
0
508
4025
1.31
6.93
1.2
1.2
1.33
1.82
u/ml
0.95
130
967
151
962
1.60
6.77
2.1
2.3
35.92
37.38
g/l
2.47
135
826
31
111
2.81
6.57
9.3
2.6
66.27
65.14
mg/l
0.04
26
73
23
70
3.30
6.41
1.2
1.5
—
—
—
0
0
375
2886
1.34
6.24
2.6
2.5
13.39
7.11
ug/l
5.00
329
2450
297
2206
1.38
6.20
1.3
1.3
—
—
—
0
0
109
661
1.67
5.98
1.7
1.6
13422.91
15912.58
e6/l
0.15
79
472
60
303
2.00
5.94
1.2
1.2
—
—
—
0
0
69
367
1.90
5.89
1.6
1.4
—
—
—
0
0
168
1135
1.51
5.84
1.4
1.3
—
—
—
0
0
65
342
1.92
5.74
4.8
4.4
—
—
—
0
0
89
520
1.73
5.61
1.3
1.3
69.01
61.95
mmol/l
0.84
79
413
49
236
2.09
5.53
1.7
1.3
45.62
23.41
%
3.02
25
145
77
435
1.79
5.46
1.7
1.4
—
—
—
0
0
29
112
2.60
5.38
1.5
1.3
5.29
3.52
%
—
7
25
55
282
1.97
5.26
5.3
3.3
—
—
—
0
0
66
360
1.85
5.25
1.5
1.4
6.08
6.50
mmol/l
0.51
58
341
298
2276
1.34
5.23
2.5
2.4
33.90
39.78
u/l
1.11
267
1917
68
376
1.83
5.19
11.4
8.8
7.58
7.63
mmol/l
0.03
59
309
61
326
1.89
5.17
4.8
3.8
55.55
56.88
%
0.22
55
267
24
86
2.80
5.14
1.0
1.1
1.26
2.69
u/ml
0.58
13
31
68
378
1.82
5.11
1.7
1.7
4.33
4.49
mmol/24h
0.17
62
322
72
410
1.77
5.00
1.6
1.5
—
—
—
0
0
88
535
1.66
4.85
1.6
1.5
33.63
30.92
g/l
1.33
77
478
10
13
7.71
4.84
1.1
1.0
—
—
—
0
0
956
8426
1.20
4.83
3.4
3.3
573.91
246.02
mg/l
1.23
645
5496
8
7
11.45
4.78
1.0
1.0
32.88
35.70
s
—
8
7
726
6242
1.21
4.77
1.8
1.8
1111.32
1160.85
nmol/l
0.75
553
4624
14
32
4.39
4.43
1.5
1.2
71.34
169.18
ng/l
—
7
20
1001
8917
1.18
4.39
4.0
3.9
12.73
9.43
mg/mmol
1.23
640
5714
78
473
1.67
4.37
1.6
1.4
6477.37
1587.84
e6/l
0.56
57
341
53
289
1.85
4.29
1.1
1.1
—
—
—
0
0
19
67
2.85
4.22
1.1
1.0
8.23
2.69
u/ml
—
6
8
958
8530
1.18
4.19
3.4
3.2
7.32
7.29
mmol/l
0.10
788
6990
69
411
1.69
4.15
1.6
1.6
—
—
—
0
0
81
504
1.62
4.13
2.2
2.1
—
—
—
0
0
52
290
1.81
3.94
1.2
1.1
—
—
—
0
0
204
1539
1.35
3.93
2.5
2.5
—
—
—
0
0
71
434
1.65
3.90
1.7
1.4
211785.22
63950.67
e6/l
0.94
45
260
262
3310
0.77
3.89
4.7
4.9
32.81
33.34
%
0.35
198
2138
42
220
1.92
3.87
1.2
1.1
—
—
—
0
0
36
680
0.52
3.76
1.2
1.4
—
—
—
0
0
74
464
1.61
3.70
1.1
1.1
22.80
13.58
u/ml
—
5
32
621
5383
1.19
3.66
5.3
4.5
1.02
1.02
kg/l
0.21
126
865
190
1435
1.35
3.66
1.1
1.2
—
—
—
0
0
620
5399
1.19
3.46
2.8
3.1
2.48
2.46
mmol/l
5.75
549
4694
700
6167
1.17
3.39
1.8
1.7
14561883.79
27840873.10
pmol/l
0.39
570
4964
104
719
1.46
3.37
1.3
1.5
250.75
271.18
ug/g
0.53
68
441
23
101
2.29
3.35
4.4
4.0
56.52
54.72
%
0.14
23
96
10
23
4.36
3.30
1.5
1.1
—
—
—
0
0
10
23
4.36
3.30
1.5
1.1
—
—
—
0
0
10
23
4.36
3.30
1.5
1.1
—
—
—
0
0
69
442
1.57
3.20
2.1
3.4
—
—
—
0
0
265
2135
1.26
3.19
1.9
2.0
152.73
166.10
ug/g
0.30
213
1655
21
92
2.29
3.10
1.0
1.0
4.85
1.38
u/ml
0.47
14
38
6
8
7.51
3.05
1.2
1.0
—
—
—
0
0
7
12
5.84
3.02
2.4
1.9
1.79
1.88
%
—
7
12
59
370
1.61
3.01
1.3
1.1
—
—
—
0
0
30
154
1.96
2.99
1.0
1.0
4.76
3.54
u/ml
0.11
14
67
550
6263
0.85
2.93
3.2
3.4
—
—
—
0
0
8
17
4.72
2.92
1.1
1.0
—
—
—
0
0
19
82
2.33
2.91
1.1
1.0
0.46
0.59
u/ml
—
10
29
2437
23574
1.16
2.87
27.1
17.2
—
—
—
0
0
90
626
1.45
2.87
2.7
2.7
—
—
—
0
0
32
172
1.87
2.81
1.1
1.1
0.58
2.06
u/ml
1.32
17
90
5
6
8.34
2.75
2.4
11.0
—
—
—
0
0
7
14
5.01
2.72
1.6
1.1
—
—
—
0
0
34
587
0.57
2.70
1.7
1.5
—
—
—
0
0
109
798
1.38
2.64
2.7
3.1
0.85
0.83
nmol/l
0.16
84
596
1776
16884
1.12
2.57
3.9
3.7
14.94
15.10
pmol/l
1.63
1606
14863
77
536
1.45
2.49
1.5
1.5
—
—
—
0
0
20
95
2.11
2.48
1.4
1.3
27.86
21.66
%
0.42
14
76
16
69
2.33
2.48
1.3
1.1
1.58
1.57
mmol/l
—
8
44
28
151
1.86
2.47
1.0
1.1
0.74
0.80
u/ml
0.06
14
61
16
70
2.29
2.41
1.2
1.1
—
—
—
0
0
927
10059
0.89
2.39
4.2
4.8
22.36
22.21
%
0.10
401
5436
41
251
1.64
2.36
1.3
1.3
—
—
—
0
0
22
111
1.99
2.35
1.4
1.7
10178.09
2987.11
u/l
—
8
34
28
154
1.83
2.34
1.2
1.1
—
—
—
0
0
141
1097
1.30
2.31
2.8
3.1
4.18
4.35
pmol/l
0.79
125
938
23
119
1.94
2.30
1.0
1.0
1.54
1.02
u/ml
0.16
14
63
49
316
1.56
2.30
1.4
1.2
—
—
—
0
0
8
23
3.48
2.27
2.4
4.8
54.63
64.61
ug/min
—
8
18
41
255
1.62
2.24
1.5
1.3
110006.04
120018.19
e6/l
0.04
28
177
14
60
2.34
2.21
1.1
1.1
1675.07
1612.15
miu/ml
0.06
14
60
10
35
2.86
2.20
1.9
1.4
45.00
47.34
umol/l
—
10
35
72
509
1.42
2.18
1.1
1.2
53.56
46.47
u/l
0.09
65
432
31
180
1.73
2.18
2.8
2.5
—
—
—
0
0
6
14
4.29
2.15
1.5
1.1
—
—
—
0
0
776
7103
1.12
2.09
1.7
1.6
18.07
19.74
nmol/l
2.68
699
5969
642
7064
0.88
2.05
3.0
3.3
0.69
0.84
ug/l
3.41
465
5157
34
207
1.65
2.04
1.7
1.7
10.73
10.76
%
0.01
34
207
27
154
1.76
2.04
1.2
1.1
—
—
—
0
0
88
653
1.36
2.03
1.3
1.2
—
—
—
0
0
241
2034
1.20
1.96
1.7
1.5
—
—
—
0
0
26
152
1.72
1.83
1.9
1.3
—
—
—
0
0
46
310
1.49
1.83
1.1
1.1
—
—
—
0
0
27
160
1.69
1.81
1.6
1.6
1.95
2.69
u/field
0.23
19
112
20
109
1.84
1.77
1.0
1.0
—
—
—
0
0
17
88
1.94
1.74
1.3
1.2
33.59
39.53
g/l
—
7
42
31
193
1.61
1.74
1.4
1.5
—
—
—
0
0
57
405
1.42
1.74
2.1
1.4
—
—
—
0
0
7
24
2.92
1.72
2.3
1.3
0.17
1.09
%
—
7
14
21
118
1.79
1.70
1.0
1.1
—
—
—
0
0
16
82
1.96
1.69
1.5
1.2
—
—
—
0
0
22
368
0.59
1.66
1.3
1.3
—
—
—
0
0
5
14
3.58
1.61
2.0
1.5
—
—
—
0
0
5
15
3.34
1.52
1.0
1.0
—
—
—
0
0
2504
24538
1.11
1.47
36.2
21.3
138.85
139.59
mmol/l
33.77
2466
23847
347
3094
1.14
1.45
3.1
4.0
18.20
23.39
ug/l
0.30
294
2589
7
28
2.50
1.45
2.4
1.3
—
—
—
0
0
1226
11662
1.09
1.44
3.4
2.8
—
—
—
0
0
58
430
1.36
1.43
3.9
2.5
—
—
—
0
0
35
237
1.48
1.41
1.0
1.1
—
—
—
0
0
251
2193
1.16
1.41
3.8
3.7
91.25
99.14
ng/l
0.84
223
1838
59
440
1.35
1.41
3.9
2.5
4.20
4.12
mmol/l
0.73
59
435
59
440
1.35
1.41
3.9
2.5
105.15
105.48
mmol/l
0.20
59
435
1008
9530
1.09
1.36
2.5
2.3
—
—
—
0
0
2505
24573
1.10
1.36
36.3
21.5
4.04
4.01
mmol/l
4.08
2465
23848
2152
22052
0.92
1.34
4.7
4.7
1.38
1.41
mmol/l
2.19
1889
19684
2175
22275
0.92
1.33
4.8
4.8
4.28
4.36
mmol/l
3.16
1932
20064
12
61
1.97
1.32
3.2
8.3
—
—
—
0
0
19
113
1.69
1.31
1.2
1.3
201.60
422.02
ug/l
—
8
59
24
154
1.56
1.25
1.7
1.3
1964.96
1792.95
ml
0.53
24
148
18
107
1.69
1.25
1.1
1.0
—
—
—
0
0
16
92
1.74
1.25
2.8
2.7
—
—
—
0
0
1229
11748
1.08
1.24
2.2
2.1
87.24
91.85
pmol/l
2.92
688
6176
5
19
2.63
1.21
1.0
1.1
—
—
—
0
0
5
19
2.63
1.21
1.0
1.0
—
—
—
0
0
8
39
2.05
1.15
1.3
1.1
—
—
—
0
0
27
183
1.48
1.13
1.3
1.2
—
—
—
0
0
43
318
1.36
1.13
1.7
2.1
—
—
—
0
0
2250
22952
0.93
1.10
5.3
5.4
2.44
2.52
mmol/l
3.69
1994
20555
31
218
1.43
1.09
1.4
1.3
—
—
—
0
0
2225
22703
0.93
1.09
5.2
5.1
6.07
6.13
mmol/l
1.27
1979
20057
21
136
1.55
1.08
1.2
1.3
1.02
1.07
nmol/l
0.12
15
100
42
312
1.35
1.08
1.2
1.3
—
—
—
0
0
30
421
0.71
1.08
1.6
1.7
—
—
—
0
0
2479
24375
1.09
1.08
20.6
11.2
23.92
25.06
u/l
2.74
2435
23211
627
5869
1.09
1.07
1.5
1.3
—
—
—
0
0
46
347
1.33
1.07
2.1
2.2
0.91
1.46
g/24h
1.16
26
174
66
826
0.79
1.07
1.1
1.2
—
—
—
0
0
288
2599
1.12
1.05
1.3
1.3
—
—
—
0
0
38
280
1.36
1.04
1.4
1.2
—
—
—
0
0
862
8181
1.07
1.03
5.5
4.5
—
—
—
0
0
117
992
1.19
1.02
3.4
2.9
0.42
0.31
g/l
0.70
55
397
7
35
2.00
1.00
1.3
2.5
0.14
0.46
u/field
—
7
35
210
1867
1.13
0.99
3.0
2.1
12.59
11.80
nmol/l
0.75
182
1595
2481
24421
1.08
0.98
36.3
21.2
88.56
86.48
umol/l
1.78
2481
24413
5
23
2.18
0.98
1.0
1.1
—
—
—
0
0
204
1812
1.13
0.97
4.4
3.3
—
—
—
0
0
9
52
1.73
0.92
1.2
1.0
—
—
—
0
0
6
28
2.15
0.91
2.7
2.6
1.63
3.11
mmol/l
—
6
23
308
3365
0.91
0.91
1.3
1.4
—
—
—
0
0
25
177
1.42
0.88
1.6
2.0
509.63
493.26
min
0.37
16
124
8
43
1.86
0.87
2.4
1.0
16.23
16.82
umol/l
—
8
36
21
144
1.46
0.87
1.1
1.5
14.63
15.09
umol/l
0.09
21
132
12
192
0.62
0.85
1.2
1.4
—
—
—
0
0
28
379
0.74
0.85
1.4
1.7
—
—
—
0
0
13
80
1.63
0.84
1.5
1.7
—
—
—
0
0
863
8248
1.06
0.84
3.0
2.7
—
—
—
0
0
127
1108
1.15
0.82
1.1
1.2
—
—
—
0
0
35
267
1.31
0.81
2.9
1.9
—
—
—
0
0
51
629
0.81
0.78
1.1
1.1
—
—
—
0
0
7
123
0.57
0.77
1.3
1.0
215.86
284.77
mg/l
—
7
103
10
162
0.62
0.76
1.6
1.6
95.00
91.37
umol/l
—
10
162
87
742
1.18
0.76
6.1
3.4
1.68
1.65
mmol/l
0.13
87
726
35
270
1.30
0.76
1.8
2.1
2.12
1.77
u/field
0.17
17
95
2139
21017
1.06
0.76
4.9
4.6
2.06
2.11
mu/l
0.30
1939
18648
14
91
1.54
0.75
3.1
2.0
—
—
—
0
0
7
38
1.84
0.73
1.4
1.1
—
—
—
0
0
9
58
1.55
0.69
1.9
1.4
—
—
—
0
0
7
42
1.67
0.68
1.1
1.3
—
—
—
0
0
2102
21363
0.95
0.68
4.3
4.2
1.31
1.26
mmol/l
3.32
1838
18852
5
28
1.79
0.66
1.6
1.7
—
—
—
0
0
37
458
0.81
0.62
1.2
1.3
9.00
30.48
e6/l
0.87
28
362
54
642
0.84
0.62
5.4
3.9
23.67
31.31
mg/l
1.50
42
408
43
522
0.82
0.61
1.0
1.1
—
—
—
0
0
9
138
0.65
0.60
1.6
1.8
—
—
—
0
0
0
20
0.00
0.60
0.0
1.4
—
—
—
0
0
8
51
1.57
0.60
1.1
1.1
—
—
—
0
0
15
209
0.72
0.59
1.0
1.1
—
—
—
0
0
10
64
1.56
0.58
1.3
1.3
—
—
—
0
0
0
23
0.00
0.58
0.0
1.3
—
—
—
0
0
0
23
0.00
0.58
0.0
3.4
—
7.75
—
0
16
36
442
0.81
0.58
1.1
1.1
—
—
—
0
0
6
35
1.72
0.57
1.7
1.2
—
—
—
0
0
12
81
1.48
0.57
1.7
2.1
—
—
—
0
0
6
36
1.67
0.56
6.8
13.2
5.95
5.62
mmol/l
—
6
36
5
89
0.56
0.56
1.6
1.5
—
—
—
0
0
80
700
1.15
0.55
6.5
3.5
7.43
7.79
mmol/l
0.67
80
685
18
134
1.35
0.53
1.0
1.1
—
—
—
0
0
1220
12500
0.96
0.52
4.6
5.6
3.54
4.43
ug/l
0.34
1041
11067
6
99
0.61
0.51
1.0
1.1
—
—
—
0
0
88
781
1.13
0.51
11.7
12.5
—
—
—
0
0
82
727
1.13
0.49
1.7
1.6
—
—
—
0
0
7
110
0.64
0.48
1.1
1.4
71.73
154.60
pmol/l
—
7
110
10
68
1.47
0.47
1.8
2.0
—
—
—
0
0
5
81
0.62
0.45
1.4
1.3
1.53
1.54
g/l
—
5
81
68
768
0.88
0.44
3.5
3.6
89.42
79.66
u/ml
0.09
68
741
7
51
1.37
0.44
3.9
8.1
—
—
—
0
0
123
1128
1.09
0.42
2.6
2.0
—
—
—
0
0
12
87
1.38
0.42
1.8
1.2
45.35
65.30
%
1.17
12
74
0
16
0.00
0.41
0.0
1.1
—
—
—
0
0
142
1531
0.92
0.39
5.2
3.8
—
—
—
0
0
31
260
1.19
0.39
1.1
1.2
278.54
333.10
nmol/l
0.77
24
202
14
106
1.32
0.39
1.8
1.4
0.97
0.94
g/l
0.10
14
106
19
152
1.25
0.37
1.3
1.5
58.00
68.83
%
0.59
14
120
18
143
1.26
0.37
1.4
1.3
—
—
—
0
0
8
116
0.69
0.37
1.9
2.6
—
—
—
0
0
250
2376
1.06
0.35
4.3
3.6
—
—
—
0
0
9
123
0.73
0.35
2.2
1.6
17.80
15.49
nmol/l
—
9
111
30
255
1.18
0.34
1.8
2.2
468.80
642.88
ml
2.26
20
154
137
1465
0.93
0.33
2.7
2.8
—
—
—
0
0
648
6306
1.03
0.32
2.9
2.6
—
—
—
0
0
1839
18183
1.03
0.32
40.5
23.7
329.37
331.57
g/l
20.53
1821
17966
10
75
1.33
0.30
1.6
1.7
—
—
—
0
0
13
163
0.80
0.29
1.4
1.8
—
—
—
0
0
281
2925
0.96
0.28
5.2
4.6
—
—
—
0
0
13
103
1.26
0.28
1.1
1.5
—
—
—
0
0
80
866
0.92
0.28
6.0
4.5
—
—
—
0
0
9
119
0.76
0.27
1.0
1.2
126.33
139.92
nmol/l
—
9
119
16
131
1.22
0.27
5.9
4.1
—
—
—
0
0
9
72
1.25
0.25
1.1
1.3
24.89
26.15
%
—
9
48
22
256
0.86
0.25
1.5
1.3
—
—
nmol/l
—
0
0
47
427
1.10
0.23
1.8
1.7
4.69
4.18
iu/l
0.20
15
124
2521
25085
1.03
0.22
45.4
26.2
39.47
39.32
%
0.51
2262
22995
23
200
1.15
0.22
2.7
3.1
—
—
—
0
0
0
11
0.00
0.21
0.0
1.7
—
—
—
0
0
0
12
0.00
0.21
0.0
1.0
—
—
—
0
0
2521
25092
1.03
0.21
44.2
26.1
242.18
236.25
e9/l
4.09
2476
24276
18
154
1.17
0.21
1.6
1.6
—
—
—
0
0
2521
25093
1.03
0.21
44.2
26.1
8.03
6.98
e9/l
64.78
2470
24163
2521
25094
1.03
0.20
44.0
26.0
92.84
91.82
fl
19.04
2489
24556
2521
25095
1.03
0.20
43.9
25.9
30.60
30.49
pg
2.01
2490
24556
2521
25096
1.02
0.20
44.2
26.1
4.35
4.39
e12/l
2.76
2470
24174
18
208
0.86
0.20
1.1
1.3
—
—
—
0
0
2202
21889
1.02
0.20
6.8
6.7
41.92
41.19
mmol/mol
2.46
2009
19776
6
51
1.18
0.19
6.5
5.9
—
—
—
0
0
2521
25100
1.02
0.19
44.5
26.2
131.86
132.91
g/l
2.65
2489
24573
24
268
0.89
0.17
1.4
1.2
—
—
—
0
0
614
6040
1.02
0.17
1.8
1.6
1.40
1.31
mmol/l
2.12
502
4985
15
173
0.87
0.16
1.3
1.7
—
—
—
0
0
134
1394
0.96
0.16
1.2
1.3
—
—
—
0
0
51
476
1.07
0.16
1.7
1.3
1.03
0.81
nmol/l
1.08
38
383
15
172
0.87
0.15
1.3
1.7
—
—
—
0
0
10
83
1.21
0.15
1.1
1.2
—
—
—
0
0
104
996
1.05
0.15
1.1
1.2
141.11
127.20
iu/ml
0.14
30
346
15
171
0.88
0.14
1.3
1.5
—
—
—
0
0
7
87
0.80
0.14
1.7
2.2
—
—
—
0
0
37
343
1.08
0.14
2.6
2.6
—
—
—
0
0
73
767
0.95
0.14
2.0
2.2
125.58
97.61
ug/min
0.28
42
456
15
170
0.88
0.13
1.3
1.7
—
—
—
0
0
39
417
0.93
0.13
1.1
1.3
—
—
—
0
0
17
153
1.11
0.11
2.5
5.0
114.17
23.85
u/ml
—
6
45
24
258
0.93
0.09
1.3
1.5
—
—
—
0
0
20
184
1.09
0.09
5.4
14.8
—
—
—
0
0
6
57
1.05
0.08
2.0
2.6
—
—
—
0
0
5
60
0.83
0.08
1.0
1.2
—
—
—
0
0
70
724
0.97
0.08
4.0
2.8
—
—
—
0
0
11
98
1.12
0.07
1.6
1.7
—
—
—
0
0
7
80
0.87
0.07
2.4
2.0
—
—
—
0
0
10
89
1.12
0.06
1.0
1.1
—
—
—
0
0
28
294
0.95
0.06
2.4
1.5
152.61
303.73
pmol/l
1.57
28
288
77
762
1.01
0.01
1.3
1.3
—
—
—
0
0
33
323
1.02
0.01
1.0
1.1
1.46
52.02
iu/ml
—
9
55
10
106
0.94
0.01
3.3
6.4
—
—
—
0
0
109
1091
1.00
0.00
2.3
3.1
306.76
2403.26
u/ml
1.16
86
930
5
57
0.88
0.00
2.6
1.4
—
—
—
0
0
5
55
0.91
0.00
1.0
1.1
—
—
—
0
0
8
82
0.98
-0.00
1.3
1.3
116.38
168.54
mmol/24h
—
8
82
0
6
0.00
-0.00
0.0
2.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
2.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
2.0
—
—
—
0
0
6
66
0.91
-0.00
1.7
1.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.3
—
234.25
—
0
8
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
5.0
—
385.33
—
0
6
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.8
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
1687.43
—
0
7
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
1978.00
—
0
5
5
58
0.86
-0.00
2.0
1.7
1.77
1.41
ug/l
—
5
52
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.3
—
—
—
0
0

Mortality – FinRegistry

Association

Association between endpoint IPF and mortality.

Females

Parameter HR [95% CI] p-value
IPF 3.691 [3.29, 4.14] < 0.001
Birth year 0.992 [0.98, 1.0] 0.045

During the follow-up period (1.1.1998 — 31.12.2019), 3391 out of 5474 females with IPF died.

Males

Parameter HR [95% CI] p-value
IPF 3.607 [3.15, 4.13] < 0.001
Birth year 0.985 [0.98, 0.99] 0.001

During the follow-up period (1.1.1998 — 31.12.2019), 5042 out of 7688 males with IPF died.

Mortality risk

Mortality risk for people of age

years, who have IPF.

N-year risk Females Males
1 0.269% 0.673%
5 1.736% 3.833%
10 4.577% 9.627%
15 8.667% 17.651%
20 15.51% 28.109%

Relationships between endpoints

Index endpoint: IPF – Idiopathic pulmonary fibrosis

GWS hits: 14

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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