respiratory failure: The significant impairment of gas exchange within the lungs resulting in hypoxia, hypercarbia, or both, to the extent that organ tissue perfusion is severely compromised. Causes include chronic obstructive pulmonary disease, asthma, emphysema, acute respiratory distress syndrome, pneumonia, pulmonary edema, pneumothorax, and congestive heart failure. Treatment requires intubation and mechanical ventilation until the time the lungs recover sufficient function. [NCIT:C26872]
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditions
|
5925 |
3. Check pre-conditions, main-only, mode, registry filtersNone 0 out of 7 registries used, show all original rules. |
0 |
4. Check minimum number of eventsNone |
0 |
5. Include endpoints |
1083 |
6. Filter based on genotype QC (FinnGen only) |
1083 |
Control definitions (FinnGen only)
- Control conditions
- not ILD_ENDPOINTS
Extra metadata
- First used in FinnGen datafreeze
- DF2
Similar endpoints
↥List of similar endpoints to
ILD-related respiratory insufficiency
based on the number of shared cases.
Similar with more cases:
- Interstitial lung disease
- Interstitial lung disease endpoints
- Other interstitial pulmonary diseases
- Respiratory diseases principally affecting the interstitium, IBD co-morbidites
- Other respiratory diseases principally affecting the interstitium
Similar with less cases:
None
Case counts by codes
↥FinnGen case counts by registry codes:
No data for upset plot.
No data for upset table.
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 5976 | 2346 | 3557 |
| Only index persons | 4503 | 1795 | 2708 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.09 | 0.07 | 0.10 |
| Only index persons | 0.09 | 0.07 | 0.10 |
| Median age at first event (years) | |||
| Whole population | 74.06 | 75.07 | 73.40 |
| Only index persons | 74.56 | 75.67 | 73.83 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 1083 | 378 | 705 |
| Unadjusted period prevalence (%) | 0.25 | 0.13 | 0.31 |
| Median age at first event (years) | 71.97 | 69.95 | 73.06 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 952
- Matched controls
- 9518
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
J84.9
ICD-10 Finland
Interstitial pulmonary disease, unspecified
10354.2
323.0
518
*
J84.1
ICD-10 Finland
Other interstitial pulmonary diseases with fibrosis
14300.2
323.0
598
*
J96.1
ICD-10 Finland
Chronic respiratory failure
80.6
323.0
449
104
J84.8
ICD-10 Finland
Other specified interstitial pulmonary diseases
+∞
292.2
265
*
GD1DD
NOMESCO Finland
High resolution CT examination of lungs
32.8
279.6
379
188
UGC12
NOMESCO Finland
Flexible bronchoscopy
16.2
235.2
422
446
GD1ED
NOMESCO Finland
Extensive high resolution CT examination of lungs
36.5
196.9
256
95
H02AB06
ATC
prednisolone; systemic
9.2
186.9
789
3292
TGC00
NOMESCO Finland
Bronchial lavation
37.3
176.0
227
79
J18.9
ICD-10 Finland
Pneumonia, unspecified
6.9
163.7
605
1921
WX725
NOMESCO Finland
Noninvasive ventilation
18.1
158.9
259
192
WX722
NOMESCO Finland
PEEP
15.5
157.8
276
244
XG410
NOMESCO Finland
Flow-volume spirometry
19.2
152.8
243
167
R06.0
ICD-10 Finland
Dyspnoea
6.4
147.1
537
1602
XG412
NOMESCO Finland
Flow-volume spirometry with bronchospasmolysis
13.4
142.2
266
268
R91
ICD-10 Finland
Abnormal findings on diagnostic imaging of lung
7.9
131.4
350
655
XG470
NOMESCO Finland
Measurement of diffusion capastity of the lungs
21.3
127.8
194
113
GD1AA
NOMESCO Finland
Thorax X-ray examination
5.6
126.3
718
3365
FB1BD
NOMESCO Finland
Extensive CT examination of arteria pulmonalis
9.7
122.6
274
380
284
Kela drug reimbursment
Nintedanib and pirfenidone
+∞
121.5
114
*
C03CA01
ATC
furosemide; systemic
5.1
120.1
633
2659
R03AC02
ATC
salbutamol; inhalant
4.7
107.0
667
3161
356
Kela drug reimbursment
Nintedanib and pirfenidone
+∞
104.1
98
*
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
5.2
101.4
395
1137
GD1AD
NOMESCO Finland
Thorax CT examination
11.4
97.9
195
211
XG466
NOMESCO Finland
Sleep oxymetry
14.4
94.9
167
138
R03BB04
ATC
tiotropium bromide; inhalant
5.5
86.7
298
722
I50.9
ICD-10 Finland
Heart failure, unspecified
4.4
80.4
368
1192
L04AX05
ATC
pirfenidone; oral
+∞
79.3
75
*
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
4.5
76.9
339
1050
L04AX01
ATC
azathioprine; systemic
11.8
76.3
147
145
NK6QA
NOMESCO Finland
Measurement of bone density from tow or more locations with X-ray
8.5
75.5
176
246
R5140
NOMESCO Finland
Monitoring the use of the aid
5.7
74.1
239
525
J15.9
ICD-10 Finland
Bacterial pneumonia, unspecified
5.3
71.5
249
596
TPH04
NOMESCO Finland
Cathetrisation of vein
3.9
71.2
376
1356
GCA98
NOMESCO Finland
Other bronchoscopic procedure on bronchus
46.6
69.6
85
20
XQ858
NOMESCO Finland
Oxygen partial pressure measurement
25.9
68.3
96
41
WX892
NOMESCO Finland
Monitored bed care
5.8
67.7
214
454
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
5.3
66.2
227
529
TGD04
NOMESCO Finland
Needle biopsy of the lungs in bronchoscopy
85.2
64.0
71
9
L04AA06
ATC
mycophenolic acid; systemic
21.6
63.2
94
48
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
3.2
62.0
478
2258
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
4.8
61.4
232
596
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
3.4
60.0
381
1549
J01MA14
ATC
moxifloxacin; systemic
5.1
58.5
206
488
J44.8
ICD-10 Finland
Other specified chronic obstructive pulmonary disease
4.1
58.1
266
820
Z94.2
ICD-10 Finland
Lung transplant status
+∞
57.9
55
*
I27.9
ICD-10 Finland
Pulmonary heart disease, unspecified
35.8
56.7
73
22
GDG10
NOMESCO Finland
Bilateral transplantation of lung
+∞
55.8
53
*
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
3.5
55.1
331
1271
I27.2
ICD-10 Finland
Other secondary pulmonary hypertension
40.5
54.3
68
18
TPH07
NOMESCO Finland
Cathetrisation of artery
4.2
53.1
233
684
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
4.2
52.6
227
655
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
2.9
52.6
545
3018
L01XE31
ATC
[U] nintedanib; oral
+∞
52.6
50
*
J20.9
ICD-10 Finland
Acute bronchitis, unspecified
3.7
51.8
272
931
GD1CD
NOMESCO Finland
Thorax extensive CT-examination
23.9
49.6
71
32
A02BC02
ATC
pantoprazole; systemic
3.0
49.2
723
4893
G47.3
ICD-10 Finland
Sleep apnoea
3.3
48.5
299
1149
R03AK06
ATC
salmeterol and fluticasone; inhalant
3.7
48.4
250
838
I50.0
ICD-10 Finland
Congestive heart failure
4.2
47.2
202
573
GD1BD
NOMESCO Finland
Thorax extensive CT-examination
5.7
47.2
145
289
TFC00
NOMESCO Finland
Catheterisation of right atrium or ventricle
13.3
46.5
83
68
J84.0
ICD-10 Finland
Alveolar and parietoalveolar conditions
+∞
45.2
43
*
DM1QA
NOMESCO Finland
Paranasal sinuses X-ray examination in one projection
7.3
44.1
111
169
R28
ICPC
Limited function/disability (R)
16.3
43.0
70
46
R02
ICPC
Shortness of breath/dyspnoea
3.6
40.1
207
682
I26.9
ICD-10 Finland
Pulmonary embolism without mention of acute cor pulmonale
5.1
40.1
137
306
GD1BT
NOMESCO Finland
Biopsy of lung with X-ray guidance
+∞
39.9
38
*
FN1AC
NOMESCO Finland
Angiography of heart and/or coronary arteries
2.7
38.6
365
1806
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
2.9
38.5
296
1292
J44.0
ICD-10 Finland
Chronic obstructive pulmonary disease with acute lower respiratory infection
4.7
37.7
137
326
WX872
NOMESCO Finland
Intensive care
5.0
37.4
128
286
R4110
NOMESCO Finland
Physiotherapy
2.6
36.0
348
1726
J96.0
ICD-10 Finland
Acute respiratory failure
11.7
35.2
66
60
J01MA12
ATC
levofloxacin; systemic
2.7
34.2
281
1263
WX721
NOMESCO Finland
Oxygen concentrator therapy
79.2
34.1
38
5
GDA11
NOMESCO Finland
Thoracoscopic biopsy of lung
79.2
34.1
38
5
J01EE01
ATC
sulfamethoxazole and trimethoprim; systemic
4.7
33.6
122
289
I27.8
ICD-10 Finland
Other specified pulmonary heart diseases
34.6
33.4
43
13
127
Kela drug reimbursment
Transplant complication
13.6
33.3
58
45
Z01.8
ICD-10 Finland
Other specified special examinations
2.7
33.0
272
1221
J43.9
ICD-10 Finland
Emphysema, unspecified
9.5
32.9
69
78
203
Kela drug reimbursment
Chronic asthma and similar chronic obstructive pulmonary diseases
2.7
32.8
264
1166
M05BA04
ATC
alendronic acid; oral
3.7
32.3
153
464
C07AB07
ATC
bisoprolol; oral
2.3
31.9
598
4060
C03DA01
ATC
spironolactone; oral
3.1
31.8
197
732
J17.3*B59
ICD-10 Finland
Pneumonia due to Pneumocystis carinii
60.4
30.3
35
6
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.3
30.3
377
2091
J45.9
ICD-10 Finland
Asthma, unspecified
2.8
29.9
227
960
J61
ICD-10 Finland
Pneumoconiosis due to asbestos and other mineral fibres
19.6
29.8
45
24
TFB00
NOMESCO Finland
Cathetrisation of pulmonal artery
7.8
29.7
70
96
L04AD01
ATC
ciclosporin; systemic
12.1
29.4
54
47
R99
ICPC
Respiratory disease other
9.9
29.0
59
63
XX4BW
NOMESCO Finland
NA
82.8
28.9
32
*
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
2.9
28.6
198
787
WX704
NOMESCO Finland
Intubation
4.0
28.3
120
329
N02AX02
ATC
tramadol; systemic, rectal
2.2
28.2
474
2989
J01AA02
ATC
doxycycline; systemic
2.4
28.2
758
5904
ZX120
NOMESCO Finland
Intravenous
3.3
27.2
155
537
L01EX09
ATC
nintedanib; oral
+∞
27.2
26
*
5150X
ICD-9 Finland
Postinflammatory pulmonary fibrosis[FIBROSIS PULMONUM E CAUSA IGNOTA]
+∞
27.2
26
*
R04.2
ICD-10 Finland
Haemoptysis
5.2
26.9
87
181
I25.1
ICD-10 Finland
Atherosclerotic heart disease
2.2
26.7
373
2152
R03AK07
ATC
formoterol and budesonide; inhalant
2.7
26.3
210
908
RK320
NOMESCO Finland
NA
13.8
26.2
45
34
B01AA03
ATC
warfarin; systemic
2.2
25.7
336
1871
J01FA06
ATC
roxithromycin; oral
2.1
25.6
410
2496
FXA00
NOMESCO Finland
Total cardiopulmonary bypass in normothermia or moderate hypothermia at concurrent surgical procedure
4.4
25.3
95
232
WX882
NOMESCO Finland
High dependency care
5.9
25.0
72
131
R03AK03
ATC
[D] fenoterol & other drugs for obstructive airway dis; inhalant
3.5
24.5
121
376
J22
ICD-10 Finland
Unspecified acute lower respiratory infection
4.6
24.4
88
206
J44.1
ICD-10 Finland
Chronic obstructive pulmonary disease with acute exacerbation, unspecified
4.8
24.4
85
192
J47
ICD-10 Finland
Bronchiectasis
8.4
24.2
54
68
A07AA02
ATC
nystatin; oral
3.7
24.1
112
331
XF400
NOMESCO Finland
ECG with 12 standard connections
2.4
24.1
243
1187
P01BA02
ATC
hydroxychloroquine; oral
3.7
24.0
112
333
SPAT1262
SPAT
Handing over of treatment supplies
2.3
23.9
257
1297
R03BA05
ATC
fluticasone; inhalant
2.6
23.9
195
848
WX726
NOMESCO Finland
High-flow oxygen therapy
128.2
23.7
25
*
FM1BE
NOMESCO Finland
Cardiac ultrasound examination through oesophagus
3.5
23.7
119
375
UGC18
NOMESCO Finland
Flexible bronchoscopy with biopsy of lung
27.5
23.7
32
12
ZX108
NOMESCO Finland
Inhalation
20.1
23.6
35
18
WX720
NOMESCO Finland
Own respiration
4.8
23.4
80
177
J44.9
ICD-10 Finland
Chronic obstructive pulmonary disease, unspecified
3.7
23.4
107
312
NK4XE
NOMESCO Finland
Joint ultrasound examination not elsewhere classified
4.4
23.2
88
217
J92.0
ICD-10 Finland
Pleural plaque with presence of asbestos
5.6
22.9
68
128
I27.0
ICD-10 Finland
Primary pulmonary hypertension
46.2
22.5
27
6
R03AL01
ATC
fenoterol and ipratropium bromide; inhalant
5.4
22.4
69
136
DM1AA
NOMESCO Finland
Paranasal sinuses X-ray examination without contrast
5.1
22.1
72
151
H02AB07
ATC
prednisone; oral
2.6
21.8
184
815
XG499
NOMESCO Finland
Other fysiological examination of respiatory function
32.0
21.6
28
9
R03AK04
ATC
salbutamol and sodium cromoglicate; inhalant
13.2
21.3
37
29
R03AL02
ATC
salbutamol and ipratropium bromide; inhalant
12.3
21.2
38
32
J45.1
ICD-10 Finland
Nonallergic asthma
3.6
21.1
102
311
XG460
NOMESCO Finland
Short time oxymetry
6.7
20.9
54
85
A28
ICPC
Limited function/disability NOS
2.3
20.9
236
1210
WX702
NOMESCO Finland
Supraglottic ventilation device
4.5
20.6
75
177
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
3.4
20.4
105
337
XW5WT
NOMESCO Finland
Other blood specimen with radiologicl guidance
33.3
20.3
26
8
M05.8
ICD-10 Finland
Other seropositive rheumatoid arthritis
3.8
20.2
88
246
R03AK08
ATC
formoterol and beclometasone; inhalant
5.4
20.2
62
122
WX408
NOMESCO Finland
General anesthesy, balanced
2.1
19.7
292
1680
A49.9
ICD-10 Finland
Bacterial infection, unspecified
2.5
19.5
170
760
PA6DE
NOMESCO Finland
Neck artery ultrasound examination with Doppler method
3.4
19.3
98
311
L04AD02
ATC
tacrolimus; systemic (calcineurin inhibitors)
18.7
19.2
29
16
J45.0
ICD-10 Finland
Predominantly allergic asthma
3.5
19.1
93
285
J01FA10
ATC
azithromycin; systemic
1.9
19.1
446
3038
J01CA04
ATC
amoxicillin; systemic
2.0
18.9
712
5727
C01DA14
ATC
isosorbide mononitrate; oral
2.1
18.9
263
1470
Z51.5
ICD-10 Finland
Palliative care
3.0
18.8
115
415
RK110
NOMESCO Finland
NA
10.6
18.8
36
35
FM1DE
NOMESCO Finland
Doppler ultrasound examination of heart
2.6
18.6
145
608
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
1.9
18.3
431
2931
J96.9
ICD-10 Finland
Respiratory failure, unspecified
15.7
18.0
29
19
I26.0
ICD-10 Finland
Pulmonary embolism with mention of acute cor pulmonale
6.0
17.7
49
85
J01FF01
ATC
clindamycin; systemic
2.0
17.7
279
1631
A02BC01
ATC
omeprazole; systemic
1.9
17.5
316
1944
M04AA01
ATC
allopurinol; systemic
2.2
17.1
200
1030
R05
ICD-10 Finland
Cough
2.2
17.1
205
1066
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
2.8
16.8
112
427
N02AA05
ATC
oxycodone; systemic
2.2
16.8
201
1046
R03BA08
ATC
ciclesonide; inhalant
3.1
16.6
96
334
XJC10
NOMESCO Finland
Oesophageal pH monitoring
23.5
16.5
23
10
C09AA05
ATC
ramipril; oral
1.9
16.3
321
2027
ZX109
NOMESCO Finland
Instruction on medicine inhalation technique
11.9
16.1
29
25
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
2.5
16.0
141
629
R50.9
ICD-10 Finland
Fever, unspecified
2.3
15.9
162
780
KA1MN
NOMESCO Finland
Glomerular filtration rate (GFR) Isotope mesurement
26.8
15.6
21
8
A02BC03
ATC
lansoprazole; oral
1.9
15.6
309
1948
WX302
NOMESCO Finland
Thoracal epidural anesthesy
3.4
15.6
77
239
R03BA01
ATC
beclometasone; inhalant
2.3
15.4
154
734
R03BA02
ATC
budesonide; inhalant
2.2
15.2
173
876
WZC30
NOMESCO Finland
Teaching
2.3
15.2
155
745
R03BB01
ATC
ipratropium bromide; inhalant
3.3
15.1
77
245
N03AX16
ATC
pregabalin; oral
2.0
15.1
239
1385
GD1UN
NOMESCO Finland
Lung circulation SPECT
14.2
15.1
25
18
WW200
NOMESCO Finland
Immunization
5.1
15.1
47
95
SPAT1263
SPAT
Sampling
1.8
15.0
417
2926
WX404
NOMESCO Finland
Intravenous generell anesthesy
2.0
14.7
202
1107
XF600
NOMESCO Finland
Bloodpressure measurement
2.9
14.3
91
338
I25.9
ICD-10 Finland
Chronic ischaemic heart disease, unspecified
2.1
14.2
172
892
J93.1
ICD-10 Finland
Other spontaneous pneumothorax
11.1
14.1
26
24
A02BC05
ATC
esomeprazole; systemic
1.7
13.9
378
2616
XF622
NOMESCO Finland
Measurement of minute volume of heart
17.9
13.9
21
12
NA2AA
NOMESCO Finland
Thoracal spine X-ray examination without contrast
4.5
13.8
49
114
N18.9
ICD-10 Finland
Chronic kidney disease, unspecified
2.6
13.8
102
413
TNX10
NOMESCO Finland
Arthrocentesis, unspecified region, unspecified region
3.0
13.8
80
280
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
2.4
13.7
119
526
J06.9
ICD-10 Finland
Acute upper respiratory infection, unspecified
1.8
13.6
290
1855
J94.1
ICD-10 Finland
Fibrothorax
76.2
13.6
15
*
48499
ICD-8 Finland
Acute interstitial pneumonia
+∞
13.6
13
*
3A006
NOMESCO Finland
NA
+∞
13.6
13
*
GD2SN
NOMESCO Finland
Lung ventilation SPECT
11.1
13.6
25
23
SPAT1255
SPAT
Intravenous administration of medicine
2.8
13.6
90
341
A01AB09
ATC
miconazole; local oral
2.6
13.5
104
431
RS123
NOMESCO Finland
NA
34.6
13.5
17
5
GDA10
NOMESCO Finland
Biopsy of lung
34.6
13.5
17
5
AN1
HP
Coronary angiography
2.0
13.5
184
1002
L01BA01
ATC
methotrexate; systemic (folic acid analog.)
3.7
13.4
58
162
R81
ICPC
Pneumonia
4.0
13.4
53
137
GD1RA
NOMESCO Finland
Dynamic X-ray examination of respiratory organs with convetional X-ray picture
26.2
13.4
18
7
XF614
NOMESCO Finland
Measurement of pulmonary artery pressure
21.5
13.4
19
9
C01DA02
ATC
glyceryl trinitrate; oral, oral aerosol, sublingual, transdermal
1.8
13.3
300
1955
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
2.1
13.2
159
823
I48
ICD-10 Finland
Atrial fibrillation and flutter
1.7
13.1
319
2128
XF603
NOMESCO Finland
Direct intraarterial blood pressure measurement
3.5
13.1
61
182
XF402
NOMESCO Finland
ECG with work load test
2.2
13.0
147
739
J43.2
ICD-10 Finland
Centrilobular emphysema
22.9
12.9
18
8
L04AA13
ATC
leflunomide; oral
5.1
12.9
40
81
WX402
NOMESCO Finland
General anaesthesia
2.1
12.7
146
740
D86.0
ICD-10 Finland
Sarcoidosis of lung
8.0
12.7
28
36
C02KX04
ATC
macitentan; oral
70.8
12.6
14
*
A10AB05
ATC
insulin aspart; parenteral (insulins and analog. for injection, fast-acting)
2.5
12.6
99
417
L04AA01
ATC
[U] ciclosporin; systemic
7.4
12.5
29
40
J43.8
ICD-10 Finland
Other emphysema
24.7
12.5
17
7
XX2XT
NOMESCO Finland
Other injection with other radiological guidance
13.4
12.5
21
16
XX6XT
NOMESCO Finland
Other intravascular therapy with radiological guidance
131.7
12.5
13
*
D50.9
ICD-10 Finland
Iron deficiency anaemia, unspecified
2.5
12.4
100
425
L04AX03
ATC
methotrexate; systemic (immunosuppressants)
2.6
12.3
94
388
I25.0
ICD-10 Finland
Atherosclerotic cardiovascular disease, so described
2.4
12.3
106
469
J09
ICD-10 Finland
Influenza due to identified zoonotic or pandemic influenza virus
4.2
12.1
45
110
M34.1
ICD-10 Finland
CR(E)ST syndrome
27.1
12.1
16
6
GX2C5
NOMESCO Finland
Short-lasting oximetry
47.3
11.9
14
*
GX1K5
NOMESCO Finland
Diffusion capacity
47.3
11.9
14
*
JN4BD
NOMESCO Finland
Extensive body CT
2.1
11.8
141
722
R06AE07
ATC
cetirizine; oral
1.7
11.8
340
2367
R03AL09
ATC
formoterol, glycopyrronium bromide and beclometasone; inhalant
4.8
11.7
38
81
M34.9
ICD-10 Finland
Systemic sclerosis, unspecified
16.7
11.7
18
11
R95
ICPC
Chron obstructive pulmonary disease
3.6
11.7
52
150
I21.49
ICD-10 Finland
Acute subendocardial infarction unspecified coronary artery status
2.5
11.6
92
386
J10.1
ICD-10 Finland
Influenza with other respiratory manifestations, seasonal influenza virus identified
6.8
11.5
28
42
JN4AD
NOMESCO Finland
Body CT examination
2.4
11.5
100
443
J99.0*M05.1
ICD-10 Finland
Rheumatoid lung disease
+∞
11.5
11
*
Z71.3
ICD-10 Finland
Dietary counselling and surveillance
3.4
11.4
54
164
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
2.2
11.3
119
579
F1246
NOMESCO Finland
NA
35.5
11.3
14
*
WX740
NOMESCO Finland
Nitrogen oxide therapy
35.5
11.3
14
*
5AB14
NOMESCO Finland
NA
35.5
11.3
14
*
M35.0
ICD-10 Finland
Sicca syndrome [Sjögren]
5.6
11.3
32
59
206
Kela drug reimbursment
Chronic coronary artery disease and dyslipidaemia associated with chronic coronary artery disease
1.7
11.3
267
1751
J45.8
ICD-10 Finland
Mixed asthma
3.8
11.2
47
129
R03DA04
ATC
theophylline; systemic, rectal
2.6
11.1
83
340
K21.9
ICD-10 Finland
Gastro-oesophageal reflux disease without oesophagitis
2.3
11.0
100
453
NH3AA
NOMESCO Finland
Foot and toes X-ray examination
2.6
11.0
80
322
R03AL06
ATC
olodaterol and tiotropium bromide; inhalant
4.5
11.0
38
87
TKC20
NOMESCO Finland
Catheterisation of bladder
2.3
11.0
107
501
RK310
NOMESCO Finland
NA
43.8
10.9
13
*
D07AB02
ATC
hydrocortisone butyrate; topical
1.7
10.9
253
1646
R04.0
ICD-10 Finland
Epistaxis
2.3
10.9
104
482
WX002
NOMESCO Finland
Sedation and analgesia
1.8
10.9
211
1297
C01DA08
ATC
isosorbide dinitrate; oral, oral aerosol, sublingual, transdermal
1.7
10.9
298
2036
RK250
NOMESCO Finland
NA
10.7
10.8
20
19
Z50.9
ICD-10 Finland
Care involving use of rehabilitation procedure, unspecified
3.6
10.8
48
139
WX730
NOMESCO Finland
Conventional respirator
4.6
10.8
36
80
M35.9
ICD-10 Finland
Systemic involvement of connective tissue, unspecified
7.7
10.7
24
32
M05BA07
ATC
risedronic acid; oral
3.4
10.6
50
151
R03DC03
ATC
montelukast; oral
2.1
10.6
127
654
N02BE01
ATC
paracetamol; systemic, rectal
1.8
10.6
785
6931
J84
ICD-10 Finland
Other interstitial pulmonary diseases
+∞
10.4
10
*
F2680
NOMESCO Finland
NA
32.9
10.3
13
*
J90
ICD-10 Finland
Pleural effusion, not elsewhere classified
3.1
10.3
55
183
GX2D5
NOMESCO Finland
Sleep oximetry
19.0
10.3
15
8
R03AC03
ATC
terbutaline; inhalant
2.0
10.2
130
684
N17.9
ICD-10 Finland
Acute renal failure, unspecified
2.7
10.2
68
261
XJC02
NOMESCO Finland
Mesurement of oesophageal pressure and pressure profile of lower oesophageal sphincter
13.3
10.2
17
13
R06.2
ICD-10 Finland
Wheezing
3.3
10.1
50
157
M06.9
ICD-10 Finland
Rheumatoid arthritis, unspecified
3.8
10.1
41
110
N02AA01
ATC
morphine; systemic, rectal
4.7
10.1
33
72
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
1.6
10.1
334
2392
J05AB01
ATC
aciclovir; systemic
1.8
10.0
177
1053
S97
ICPC
Chronic ulcer skin
2.5
10.0
77
321
M34.0
ICD-10 Finland
Progressive systemic sclerosis
40.5
10.0
12
*
WZC10
NOMESCO Finland
Extensive specialist consultion with written report
3.1
9.9
56
191
R03AC13
ATC
formoterol; inhalant
2.8
9.9
65
245
GA1AE
NOMESCO Finland
Ultrasound examination of thorax
4.2
9.8
36
88
SPAT1222
SPAT
Counselling/guidance promoting independent living
1.8
9.8
175
1044
E66.01
ICD-10 Finland
Obesity due to excess calories
2.7
9.8
66
255
GA4YT
NOMESCO Finland
Puncture of pleura with ultrasound guidance
3.1
9.7
52
174
L88
ICPC
Rheumatoid/seropositive arthritis
3.4
9.6
45
136
PD4DE
NOMESCO Finland
Lower extremity artery ultrasound examination with Doppler method
4.1
9.6
36
90
R4190
NOMESCO Finland
Nutritional therapy
3.8
9.6
40
110
SPAT1060
SPAT
Administration of oxygen
11.5
9.6
17
15
WZC00
NOMESCO Finland
Planning of intervention or health care consultation
1.6
9.5
290
2022
FXD00
NOMESCO Finland
Use of ECHLA without concurrent surgical procedure
101.0
9.4
10
*
WX105
NOMESCO Finland
Surface analgesia on skin or mucosa
2.3
9.4
85
386
XF404
NOMESCO Finland
Ambulatory ECG
2.1
9.4
112
576
I25.2
ICD-10 Finland
Old myocardial infarction
2.1
9.3
112
577
J01FA15
ATC
telithromycin; oral
2.3
9.3
89
413
H02AB04
ATC
methylprednisolone; systemic
1.9
9.3
136
754
D07AC01
ATC
betamethasone; topical
1.6
9.2
306
2179
TPH30
NOMESCO Finland
Insertion of central venous catheter through periferal vein
5.0
9.2
28
57
M10.9
ICD-10 Finland
Gout, unspecified
2.2
9.1
95
460
ZXA10
NOMESCO Finland
Bilateral
1.7
9.1
194
1219
B01AB05
ATC
enoxaparin; parenteral
1.6
9.1
301
2144
RS230
NOMESCO Finland
NA
10.2
9.0
17
17
R03AC12
ATC
salmeterol; inhalant
2.7
9.0
60
228
X69
ICD-10 Finland
Intentional self-poisoning by and exposure to other and unspecified chemicals and noxious substances
5.1
9.0
27
54
TPH90
NOMESCO Finland
Removal of fixed intravenous catheter
5.1
9.0
27
54
WYA30
NOMESCO Finland
Preparations for expected poor cooperation
2.4
8.9
76
334
N03AX12
ATC
gabapentin; oral
1.9
8.9
142
811
A07EC01
ATC
sulfasalazine; oral, rectal
2.3
8.8
79
357
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
2.7
8.8
59
225
M80.4
ICD-10 Finland
Drug-induced osteoporosis with pathological fracture
10.8
8.8
16
15
A46
ICD-10 Finland
Erysipelas
1.8
8.7
156
929
T36
ICD-10 Finland
Poisoning by systemic antibiotics
3.8
8.7
35
94
M34.8
ICD-10 Finland
Other forms of systemic sclerosis
50.4
8.7
10
*
J67.9
ICD-10 Finland
Hypersensitivity pneumonitis due to unspecified organic dust
50.4
8.7
10
*
XG467
NOMESCO Finland
Nocturnal CO2 monitoring
50.4
8.7
10
*
SPAT1253
SPAT
Initiation, adjustment, discontinuation or repetition of medication
1.6
8.7
297
2127
J01DB01
ATC
cefalexin; oral
1.6
8.6
709
6187
J01DA01
ATC
[U] cefalexin; systemic
1.5
8.6
548
4512
A10AC01
ATC
insulin (human); parenteral (insulins and analog. for injection, intermediate-acting)
2.2
8.6
93
455
R2110
NOMESCO Finland
Giving the first information
2.6
8.6
63
257
E0000UV
ATC
NA
1.5
8.6
326
2394
QDB10
NOMESCO Finland
Major dressing of wound of skin of lower limb
2.5
8.6
66
277
Y57
ICD-10 Finland
Adverse effects in the therapeutic use of other and unspecified drugs and medicaments
4.1
8.5
32
81
N19
ICD-10 Finland
Unspecified kidney failure
2.8
8.5
53
194
R2130
NOMESCO Finland
Counselling and guidance which enhance independent living
2.2
8.5
90
437
N05CF01
ATC
zopiclone; oral
1.6
8.5
309
2240
J99.1
ICD-10 Finland
Respiratory disorders in other diffuse connective tissue disorders
90.8
8.4
9
*
J82
ICD-10 Finland
Pulmonary eosinophilia, not elsewhere classified
90.8
8.4
9
*
313
Kela drug reimbursment
Abatacept, adalimumab, anakinra, certolizumab pegol, etanercept, golimumab, infliximab, ixekizumab, sarilumab, secukinumab, tocilizumab and ustekinumab (rheumatoid diseases)
4.9
8.4
26
54
NH3EA
NOMESCO Finland
Feet X-ray examination with load
4.9
8.4
26
54
C08CA02
ATC
felodipine; oral
1.9
8.4
120
661
T86.8
ICD-10 Finland
Failure and rejection of other transplanted organs and tissues
+∞
8.3
8
*
J99.1*M35.0
ICD-10 Finland
Respiratory disorders in sicca syndrome [Sjögren]
+∞
8.3
8
*
GD5BD
NOMESCO Finland
Thorax and upper abdomen combined extensive CT examination of
3.6
8.3
36
103
R05
ICPC
Cough
1.7
8.3
190
1220
UJF32
NOMESCO Finland
Coloscopy
1.6
8.3
270
1903
K23.8*B37.8
ICD-10 Finland
Esophagitis caused by candidiasis
9.5
8.3
16
17
C10AA03
ATC
pravastatin; oral
2.1
8.3
98
502
R03AK10
ATC
vilanterol and fluticasone furoate; inhalant
3.2
8.3
42
136
I20.81
ICD-10 Finland
Other angina pectoris stenosed coronary artery
1.9
8.2
124
699
WX110
NOMESCO Finland
Local anesthesy
1.5
8.2
548
4542
C08CA05
ATC
nifedipine; systemic
2.2
8.2
84
406
J80
ICD-10 Finland
Adult respiratory distress syndrome
11.8
8.1
14
12
2AX04
NOMESCO Finland
NA
17.3
8.1
12
7
R01AD08
ATC
fluticasone; nasal
1.6
8.1
208
1379
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
2.2
8.1
78
365
ND2DA
NOMESCO Finland
Bilateral hand X-ray examination
5.1
8.1
24
48
E66.00
ICD-10 Finland
Metabolic syndrome
2.7
8.0
55
215
1CX08
NOMESCO Finland
NA
10.1
8.0
15
15
WX000
NOMESCO Finland
Monitoring vital functions without anesthesy
2.9
8.0
48
174
Z94.1
ICD-10 Finland
Heart transplant status
22.2
8.0
11
5
M05.9
ICD-10 Finland
Seropositive rheumatoid arthritis, unspecified
3.9
8.0
31
81
H25.1
ICD-10 Finland
Senile nuclear cataract
1.5
8.0
312
2297
A06AD11
ATC
lactulose; oral
1.7
7.9
171
1076
QDB05
NOMESCO Finland
Revision of wound of skin of lower limb
3.2
7.9
39
124
G04BE03
ATC
sildenafil; oral
4.0
7.9
30
77
379
Kela drug reimbursment
Apixaban, dabigatran, edoxaban and rivaroxaban for the long-term prevention of recurrent deep veinthrombosis and pulmonary embolism
3.8
7.9
32
87
J98.6
ICD-10 Finland
Disorders of diaphragm
13.2
7.9
13
10
CJE20
NOMESCO Finland
Phakoemulsification with implantation of artificial lens in posterior chamber
1.5
7.9
365
2785
JN3AD
NOMESCO Finland
Abdominal CT examination
2.1
7.9
84
412
NA7EA
NOMESCO Finland
Scoliosis X-ray examination
5.5
7.9
22
41
M81.9
ICD-10 Finland
Osteoporosis, unspecified
2.8
7.8
50
188
I50
ICD-10 Finland
Heart failure
2.7
7.8
53
205
J01.0
ICD-10 Finland
Acute maxillary sinusitis
1.8
7.8
138
817
J01DA09
ATC
[U] cefadroxil; inhalant, oral
1.6
7.8
226
1548
B01AF02
ATC
apixaban; oral
1.9
7.8
122
693
ND2AA
NOMESCO Finland
Hand and fingers X-ray examination
2.2
7.7
74
346
A02BA03
ATC
famotidine; systemic
2.6
7.7
56
225
GX1D5
NOMESCO Finland
Flow volume spirometry
45.3
7.7
9
*
6BA02
NOMESCO Finland
NA
45.3
7.7
9
*
K21.0
ICD-10 Finland
Gastro-oesophageal reflux disease with oesophagitis
1.9
7.7
111
614
J01FA09
ATC
clarithromycin; systemic
1.6
7.6
231
1598
TDM10
NOMESCO Finland
Puncture of maxillary antrum
3.1
7.6
40
134
1CX01
NOMESCO Finland
NA
25.2
7.6
10
*
R78
ICPC
Acute bronchitis/bronchiolitis
4.4
7.6
26
61
UDH02
NOMESCO Finland
Rhinopharyngoscopy
2.4
7.6
62
269
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
1.8
7.5
144
872
A02BA02
ATC
ranitidine; systemic
1.6
7.5
207
1396
C08CA01
ATC
amlodipine; oral
1.5
7.5
376
2912
SPAT1083
SPAT
Initiation and monitoring of IV fluid therapy
2.5
7.5
55
224
TNH11
NOMESCO Finland
Injection of diagnostic or therapeutic substance in ankle joint or foot joint
7.2
7.5
17
24
R21
NOMESCO Finland
Counselling and guidance in rehabilitation
6.0
7.4
19
32
KH1AE
NOMESCO Finland
Urinary tract ultrasound examination
2.2
7.4
71
332
E000003
ATC
NA
2.8
7.4
44
160
A40.3
ICD-10 Finland
Sepsis due to Streptococcus pneumoniae
6.9
7.3
17
25
AK3
HP
BLTX (both lung transplants)
+∞
7.3
7
*
C02KX01
ATC
bosentan; oral
+∞
7.3
7
*
WZB00
NOMESCO Finland
Telephone receipt or other advice
1.6
7.3
210
1429
RS221
NOMESCO Finland
NA
4.7
7.2
23
50
SPAT1254
SPAT
Administration of medicine
1.7
7.2
154
968
XG474
NOMESCO Finland
Exhalation nntrogen oxide
4.0
7.2
27
69
QBA25
NOMESCO Finland
Destruction of lesion of skin of trunk
3.9
7.2
28
74
I50.1
ICD-10 Finland
Left ventricular failure
2.1
7.2
75
365
A41.9
ICD-10 Finland
Sepsis, unspecified
2.7
7.2
47
181
ZXA00
NOMESCO Finland
Right side
1.5
7.2
267
1935
B25.9
ICD-10 Finland
Cytomegaloviral disease, unspecified
30.2
7.2
9
*
213
Kela drug reimbursment
Fat metabolism disorder associated with chronic coronary artery disease
1.8
7.1
114
654
XX4AW
NOMESCO Finland
NA
20.2
7.1
10
5
SPAT1059
SPAT
Spirometry at the office
2.4
7.1
56
238
R60.0
ICD-10 Finland
Localized oedema
1.8
7.1
112
640
281
Kela drug reimbursment
Abatacept, adalimumab, anakinra, certolizumab pegol, etanercept, golimumab, infliximab, ixekizumab, sarilumab, secukinumab and tocilizumab
4.8
7.0
22
47
M06.8
ICD-10 Finland
Other specified rheumatoid arthritis
10.1
7.0
13
13
T90
ICPC
Diabetes non-insulin dependent
1.5
7.0
241
1710
WX100
NOMESCO Finland
Conjunctival surface anesthesia
1.8
7.0
133
805
E03.9
ICD-10 Finland
Hypothyroidism, unspecified
1.9
7.0
105
588
I11.0
ICD-10 Finland
Hypertensive heart disease with (congestive) heart failure
2.8
7.0
41
148
N06AA09
ATC
amitriptyline; systemic
1.9
6.9
94
509
3AC01
NOMESCO Finland
NA
5.5
6.9
19
35
Z95.1
ICD-10 Finland
Presence of aortocoronary bypass graft
2.2
6.9
70
335
M81.4
ICD-10 Finland
Drug-induced osteoporosis
13.9
6.9
11
8
WX400
NOMESCO Finland
Inhalation anesthesy
3.0
6.9
39
135
EP1AE
NOMESCO Finland
Neck ultrasound examination
2.3
6.9
58
257
132
Kela drug reimbursment
Sarcoidosis
8.3
6.8
14
17
IAZ97
NOMESCO Finland
Psychiatric consultation in another specialty
8.3
6.8
14
17
E66.2
ICD-10 Finland
Extreme obesity with alveolar hypoventilation
6.8
6.8
16
24
J46
ICD-10 Finland
Status asthmaticus
3.4
6.8
30
89
C01AA05
ATC
digoxin; systemic
1.8
6.8
114
664
E66.8
ICD-10 Finland
Other obesity
2.8
6.8
40
145
G30.1
ICD-10 Finland
Alzheimer disease with late onset
0.3
6.8
11
402
J92.9
ICD-10 Finland
Pleural plaque without asbestos
4.7
6.7
21
45
A01AB04
ATC
amphotericin B; local oral
2.4
6.7
54
233
RF210
NOMESCO Finland
NA
3.3
6.7
31
95
B01AC04
ATC
clopidogrel; oral
1.6
6.7
198
1355
SPAT1148
SPAT
Treatment of chronic ulcer or burn
1.7
6.6
150
954
RS220
NOMESCO Finland
NA
4.3
6.6
23
55
WYA20
NOMESCO Finland
Home visit
3.6
6.6
28
80
SPAT1028
SPAT
Ultrasound examination of paranasal sinuses
2.6
6.6
46
181
J12.8
ICD-10 Finland
Other viral pneumonia
7.9
6.6
14
18
S81.8
ICD-10 Finland
Open wound of other parts of lower leg
2.8
6.6
39
141
R06.5
ICD-10 Finland
Mouth breathing
2.0
6.6
77
392
J32.0
ICD-10 Finland
Chronic maxillary sinusitis
2.2
6.5
61
283
R03BB05
ATC
aclidinium bromide; inhalant
10.1
6.5
12
12
XX9XE
NOMESCO Finland
Other ultrasound examination
6.9
6.5
15
22
A04.7
ICD-10 Finland
Enterocolitis due to Clostridium difficile
3.0
6.5
34
115
A07AA09
ATC
vancomycin; oral
4.3
6.4
22
52
J01GB01
ATC
tobramycin; inhalant, parenteral
70.3
6.4
7
*
FXF00
NOMESCO Finland
Decannulation after ECHLA or ECLA
70.3
6.4
7
*
XQ841
NOMESCO Finland
Examination of dermatosis with microscope
70.3
6.4
7
*
GD1FN
NOMESCO Finland
Lung ventilation isotope imaging
70.3
6.4
7
*
F32.9
ICD-10 Finland
Depressive episode, unspecified
2.0
6.4
80
420
X59
ICD-10 Finland
Exposure to unspecified factor
1.7
6.4
148
951
E11.9
ICD-10 Finland
Type 2 diabetes mellitus, without complications
1.5
6.4
252
1844
N02AJ06
ATC
codeine and paracetamol; systemic
1.5
6.4
290
2184
J93.8
ICD-10 Finland
Other pneumothorax
8.2
6.3
13
16
Z03.5
ICD-10 Finland
Observation for other suspected cardiovascular diseases
2.1
6.3
71
357
JBC01
NOMESCO Finland
Laparoscopic gastro-oesophageal antireflux operation
3.7
6.3
25
68
R01AD58
ATC
fluticasone, combinations; inhalant, nasal
1.7
6.3
125
766
XV5WT
NOMESCO Finland
NA
+∞
6.3
6
*
J01DA06
ATC
[U] cefuroxime; systemic
1.7
6.3
118
712
SPAT1325
SPAT
Vaccination
1.4
6.2
343
2682
RS310
NOMESCO Finland
NA
26.9
6.2
8
*
7931A
ICD-9 Finland
Nonspecific abnormal findings on radiological and other examination of body structure, Lung field
7.1
6.2
14
20
R03BB07
ATC
umeclidinium bromide; inhalant
7.1
6.2
14
20
UJF92
NOMESCO Finland
Capsular endoscopy
3.6
6.2
26
74
N18.8
ICD-10 Finland
Other chronic renal failure
2.6
6.2
42
166
J13
ICD-10 Finland
Pneumonia due to Streptococcus pneumoniae
5.4
6.2
17
32
R05FB02
ATC
cough suppressants and expectorants
1.4
6.2
335
2612
R29
ICPC
Respiratory symptom/complaint other
2.2
6.1
58
271
I48.9
ICD-10 Finland
Atrial fibrillation and atrial flutter, unspecified
2.1
6.1
69
346
H03AA01
ATC
levothyroxine sodium; systemic
1.6
6.1
184
1263
J02AC03
ATC
voriconazole; systemic
12.6
6.1
10
8
81
HP
Angiography of the heart and coronary arteries
1.8
6.0
98
566
XQ848
NOMESCO Finland
Dermatological photography
2.9
6.0
33
115
RK290
NOMESCO Finland
NA
10.1
6.0
11
11
I20.00
ICD-10 Finland
Unstable angina
2.4
6.0
47
201
AA1AD
NOMESCO Finland
CT of head and brain
1.5
6.0
250
1844
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
215
60
44.46
307.65
2.9
1.5
—
—
—
0
0
317
373
11.60
261.95
4.2
2.8
—
—
—
0
0
215
148
17.88
247.56
2.7
1.4
—
—
—
0
0
247
218
14.38
246.87
3.1
1.5
—
—
—
0
0
533
1230
7.56
243.98
13.0
7.5
5.2
5.1
kpa
1.10
508
1179
532
1231
7.53
242.68
13.0
7.4
9.4
11.8
kpa
31.96
506
1180
249
231
13.70
241.00
3.2
1.5
—
—
—
0
0
526
1238
7.32
234.72
13.1
7.4
2.3
1.2
mmol/l
6.43
440
948
193
166
13.93
194.43
16.6
5.2
577.8
306.0
iu/ml
0.37
61
26
209
228
11.12
179.34
2.6
1.3
—
—
—
0
0
446
1121
6.06
178.87
14.0
7.8
92.9
95.3
%
10.09
424
1082
162
119
15.83
178.56
2.8
1.4
—
—
—
0
0
105
27
42.96
173.77
2.5
1.2
—
—
—
0
0
140
95
16.78
160.71
3.6
1.5
—
—
—
0
0
546
1772
5.20
159.25
3.6
1.8
—
—
—
0
0
157
136
13.33
156.57
2.1
1.4
—
—
—
0
0
152
125
13.98
156.48
3.3
1.4
—
—
—
0
0
171
170
11.76
155.89
3.3
1.6
—
—
—
0
0
292
556
6.82
154.88
14.0
10.1
25.3
24.4
mmol/l
2.98
271
526
146
122
13.68
148.69
2.1
1.4
—
—
—
0
0
431
1236
5.13
144.11
3.4
1.8
—
—
—
0
0
427
1241
5.03
139.89
3.3
1.8
—
—
—
0
0
136
128
12.01
128.02
6.9
2.7
1171.0
2632.0
u/ml
—
13
10
282
621
5.79
126.67
4.5
2.7
10.1
10.9
g/l
1.45
269
559
794
4060
4.58
114.79
16.0
5.8
21.9
26.0
%
21.21
777
3752
784
3974
4.52
114.70
15.1
5.6
63.8
58.5
%
27.06
767
3695
352
1018
4.64
113.08
16.7
8.1
122.6
120.5
g/l
0.99
338
985
338
986
4.53
106.71
5.9
3.1
279.1
249.9
ng/l
0.47
317
908
268
666
5.02
103.20
9.4
4.3
2.7
1.9
mmol/l
2.72
229
491
245
571
5.25
101.70
20.4
10.8
—
—
—
0
0
319
939
4.40
98.74
15.5
6.7
11.9
11.4
mmol/l
0.44
303
894
167
279
6.89
98.52
2.1
1.5
154.5
165.0
titre
0.05
11
12
270
702
4.79
97.99
9.8
4.2
5.3
5.1
kpa
2.88
260
650
67
30
23.74
92.27
3.6
1.3
34.2
59.4
ug/l
2.67
67
30
106
112
10.38
91.54
3.5
4.4
—
—
—
0
0
258
693
4.57
89.25
12.4
6.5
25.4
24.4
mmol/l
2.81
243
651
94
100
10.20
80.62
2.6
1.7
—
—
—
0
0
139
235
6.64
80.59
1.3
1.2
0.3
0.7
u/ml
—
5
21
139
236
6.61
80.24
11.2
7.9
104.4
105.2
mmol/l
0.90
127
214
95
107
9.64
78.07
2.6
1.7
—
—
—
0
0
83
78
11.44
77.56
1.6
1.2
—
—
u/ml
—
0
0
195
481
4.72
74.30
3.2
1.8
2.6
2.2
ug/l
0.11
173
420
175
400
5.03
73.09
1.6
1.2
262.8
206.6
u/ml
0.44
159
361
388
1560
3.32
72.75
10.0
3.2
0.8
0.8
mmol/l
0.12
366
1455
186
449
4.79
72.71
9.1
5.4
1.8
1.6
%
3.74
173
423
127
217
6.50
72.68
3.2
2.2
129.5
128.8
g/l
0.07
56
168
804
4918
3.46
72.28
19.3
8.7
5.4
4.3
e9/l
26.57
767
4264
325
1179
3.51
71.85
1.4
1.2
46.8
36.2
iu/ml
0.68
120
356
535
2639
3.03
69.61
7.5
3.1
34.0
35.1
u/l
0.11
524
2502
614
3299
2.99
67.78
6.0
3.2
2520.3
1852.3
ng/l
2.06
580
2875
342
1344
3.26
65.65
10.7
5.4
1.1
1.0
mmol/l
3.47
321
1233
91
121
8.12
65.35
1.4
1.4
107.9
107.8
u/ml
0.00
20
14
96
138
7.54
64.44
1.1
1.1
—
—
—
0
0
774
4820
3.12
63.49
14.1
6.1
12.3
12.5
umol/l
0.23
760
4559
147
327
5.04
63.06
1.6
2.0
39.3
37.4
u/l
0.42
132
284
55
37
15.61
62.59
2.4
2.0
2649.3
49642.2
u/ml
—
13
9
48
25
20.04
61.79
1.1
1.2
—
—
—
0
0
75
85
9.41
61.15
1.2
1.1
—
—
—
0
0
423
1949
2.92
60.50
7.2
4.2
456.9
308.5
ng/l
0.79
381
1693
43
18
24.84
60.44
1.4
1.2
—
—
—
0
0
95
145
7.09
60.34
1.3
1.2
19.0
2.7
u/ml
—
10
10
401
1820
2.91
58.66
3.3
1.7
1.8
1.5
mg/l
0.48
346
1426
74
88
8.95
58.11
1.4
1.2
2.7
5.0
u/ml
0.29
25
24
716
4397
2.85
57.88
15.6
6.3
1.2
1.2
mmol/l
8.65
678
3959
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
158
400
4.45
57.63
4.9
2.7
0.3
0.4
u/ml
0.54
101
229
111
209
5.80
57.22
2.3
1.4
0.2
0.2
g/l
0.35
104
200
55
44
13.12
56.71
2.8
1.5
—
—
—
0
0
102
180
6.15
56.23
1.4
1.2
17.5
2.2
u/ml
0.46
18
19
55
45
12.82
55.94
2.8
1.5
—
—
—
0
0
102
181
6.12
55.90
1.4
1.2
16.1
7.0
u/ml
0.47
23
26
342
1464
2.95
55.21
3.5
2.5
2.3
2.3
g/l
0.02
324
1350
330
1398
2.96
54.16
3.6
2.5
18.1
21.9
%
5.77
266
1186
65
72
9.54
53.85
2.9
1.5
—
—
—
0
0
103
192
5.82
53.60
1.4
1.2
10.3
20.6
u/ml
—
5
7
72
92
8.31
53.31
1.4
1.2
3.1
6.4
u/ml
0.74
44
44
58
57
10.69
52.35
2.7
1.5
—
—
—
0
0
48
35
14.30
52.17
1.8
1.2
—
—
—
0
0
54
48
11.79
52.11
2.0
2.2
415.5
670.5
e6/l
0.72
47
41
742
4792
2.74
51.68
17.7
7.1
1.2
1.2
mmol/l
5.55
647
4032
109
222
5.35
51.48
1.6
1.3
—
—
—
0
0
109
222
5.35
51.48
1.6
1.3
—
—
—
0
0
123
279
4.85
51.26
7.7
3.1
26.1
24.8
mmol/l
2.16
116
238
215
744
3.36
49.57
2.3
1.7
—
—
—
0
0
56
8
73.58
49.55
3.8
1.0
—
—
—
0
0
349
1593
2.76
49.07
3.6
2.5
10.3
12.1
umol/l
6.18
337
1470
105
217
5.25
48.73
2.4
1.5
—
—
—
0
0
51
46
11.59
48.72
2.1
2.0
16.6
17.8
%
0.15
33
22
51
47
11.34
48.03
2.1
2.3
0.2
0.2
e9/l
0.59
46
41
275
1122
2.94
47.62
1.3
1.3
53.7
12.2
u/ml
0.83
59
388
49
44
11.62
46.92
2.3
2.1
—
—
—
0
0
658
4188
2.46
44.27
10.2
4.9
32.5
34.6
g/l
16.77
628
3877
52
56
9.70
43.90
1.7
1.3
—
—
—
0
0
102
226
4.88
43.57
14.9
4.7
3.8
2.8
mmol/l
2.52
91
155
82
151
5.79
43.09
5.5
2.8
5.3
4.6
e9/l
1.49
82
151
46
43
11.13
42.87
4.3
4.1
—
—
—
0
0
231
904
2.98
42.72
2.3
2.2
0.2
0.2
g/l
0.31
217
841
83
156
5.68
42.67
6.1
3.2
61.4
59.6
%
0.51
83
156
97
211
4.95
42.33
1.8
2.1
11.4
12.2
mg/l
0.29
88
190
71
124
6.06
39.37
1.2
1.2
318.4
292.7
u/ml
0.22
44
69
151
482
3.48
39.10
4.3
4.1
25.0
23.9
mmol/l
2.87
140
439
93
209
4.77
38.99
4.8
2.5
15.9
15.9
%
0.03
47
108
268
1210
2.61
37.18
4.7
3.8
287.2
248.2
u/l
2.96
262
1148
71
131
5.73
37.18
1.2
1.2
—
—
—
0
0
236
1001
2.74
37.09
5.9
3.6
6.3
5.8
kpa
4.12
218
972
49
61
8.37
36.94
1.1
1.1
—
—
—
0
0
234
998
2.72
36.32
6.1
3.6
2.9
2.0
mmol/l
2.45
193
775
233
1011
2.66
34.82
3.0
2.7
8.8
8.9
umol/l
0.05
217
893
765
5545
2.29
33.44
14.7
5.1
7.0
6.9
mmol/l
1.03
738
5232
42
51
8.53
32.27
2.3
3.0
37.6
34.4
%
0.29
33
17
273
1342
2.38
30.90
18.8
6.8
103.6
104.2
mmol/l
1.13
263
1302
35
36
10.01
30.45
1.2
1.1
—
—
—
0
0
415
2449
2.13
29.86
7.8
2.9
399.8
8019.1
umol/l
9.60
374
2060
181
744
2.72
29.79
2.0
2.2
336.8
373.2
nmol/l
1.19
172
671
302
1578
2.27
29.46
4.3
2.0
30.5
30.0
s
0.62
293
1528
207
915
2.56
29.39
19.1
7.4
1.3
1.5
mmol/l
1.45
192
881
826
6327
2.29
29.39
12.5
4.1
20.7
14.3
mm/h
17.54
812
5767
457
2841
2.05
28.19
3.8
2.5
61.8
57.0
u/l
1.15
439
2617
368
2115
2.12
28.02
5.1
2.6
3.9
4.4
e6/l
0.73
347
1882
96
287
3.57
27.24
1.5
1.6
—
—
—
0
0
39
55
7.32
26.41
1.6
1.1
0.6
0.9
u/ml
0.13
28
31
466
2979
1.99
26.03
6.9
3.5
53.1
101.6
e6/l
0.85
405
2367
256
1321
2.23
25.27
4.1
2.4
2.1
1.8
%
3.11
234
1172
859
6845
2.23
25.26
19.2
7.5
82.2
80.6
u/l
0.37
848
6391
39
58
6.94
25.18
1.3
1.1
140.0
93.3
titre
—
8
9
26
23
11.56
24.97
1.2
1.1
1.0
1.1
ratio
—
8
7
775
5993
2.03
23.90
8.4
4.9
142.8
1882.9
e6/l
1.71
13
121
24
21
11.66
23.18
5.2
7.7
—
—
—
0
0
48
97
5.13
22.71
2.0
1.6
—
—
—
0
0
48
97
5.13
22.71
2.0
1.6
—
—
—
0
0
48
97
5.13
22.71
2.0
1.6
—
—
—
0
0
21
16
13.36
22.01
1.0
1.1
—
—
—
0
0
20
14
14.54
21.96
1.1
1.2
—
—
—
0
0
145
621
2.54
21.64
2.0
1.5
—
—
—
0
0
512
3528
1.86
21.56
6.8
3.4
—
—
—
0
0
36
59
6.28
21.21
2.2
1.7
—
—
—
0
0
36
59
6.28
21.21
2.2
1.7
—
—
—
0
0
36
59
6.28
21.21
2.2
1.7
—
—
—
0
0
36
59
6.28
21.21
2.2
1.7
—
—
—
0
0
48
103
4.83
21.19
1.0
1.1
1.6
1.6
g/l
0.23
41
93
416
2704
1.87
20.92
6.6
3.4
0.4
0.5
e6/l
0.40
357
2106
32
47
6.99
20.88
2.2
1.7
—
—
—
0
0
32
47
6.99
20.88
2.2
1.7
—
—
—
0
0
497
3418
1.84
20.84
3.4
2.2
74.5
78.6
nmol/l
2.89
464
2957
32
48
6.84
20.49
2.2
1.8
—
—
—
0
0
157
719
2.38
20.20
2.1
1.6
—
—
—
0
0
437
2909
1.84
20.19
5.0
2.1
124.9
242.4
u/l
3.40
416
2724
400
2595
1.86
20.04
3.1
2.2
3.7
3.1
mg/l
2.78
365
2195
127
529
2.59
20.02
2.2
1.9
1.6
1.6
g/l
0.47
113
459
42
86
5.04
19.57
1.4
1.2
71.7
78.7
u/ml
—
7
5
542
3882
1.79
19.40
7.2
4.2
48.9
63.0
ng/l
0.66
454
3008
24
28
8.74
18.95
1.1
1.2
—
—
—
0
0
71
221
3.37
18.88
2.2
1.6
—
—
—
0
0
53
135
4.08
18.86
1.5
1.1
77.6
30.6
u/ml
—
12
8
111
446
2.66
18.79
3.1
1.9
—
—
—
0
0
181
916
2.17
18.26
2.2
2.7
65.0
65.9
g/l
0.72
171
819
19
17
11.36
18.02
1.2
1.9
85.7
90.2
%
0.13
14
11
19
17
11.36
18.02
1.2
1.1
89.1
89.9
%
0.04
14
11
86
319
2.84
16.95
1.5
1.3
—
—
—
0
0
491
3510
1.73
16.93
4.1
2.8
204.4
155.5
ug/l
2.54
466
3171
150
727
2.23
16.78
1.9
1.7
1.6
1.6
%
0.01
129
596
264
1599
1.86
15.84
5.4
3.2
2.2
1.8
e6/l
0.36
175
928
29
52
5.70
15.61
1.0
1.2
—
—
—
0
0
98
407
2.55
15.48
2.6
1.8
—
—
—
0
0
69
239
3.02
15.38
1.6
1.6
36.7
24.5
iu/ml
0.11
17
55
28
52
5.50
14.53
2.2
2.3
562.3
610.0
e6/l
0.13
16
22
65
227
2.98
14.29
3.1
2.3
31.7
33.8
umol/l
0.37
58
181
54
175
3.20
13.48
5.3
4.1
1.6
1.4
%
0.19
44
137
17
22
7.83
12.31
1.9
2.1
—
—
—
0
0
15
17
8.93
12.02
2.3
1.6
—
—
—
0
0
151
831
1.95
11.89
4.4
3.0
4.3
4.5
kpa
0.44
140
806
63
242
2.70
11.64
2.6
3.0
2.0
1.8
mg/l
1.23
58
217
128
670
2.03
11.61
6.7
3.2
121.5
125.9
g/l
1.23
116
653
37
105
3.61
11.37
2.0
1.4
—
—
—
0
0
26
57
4.65
11.22
1.3
1.1
—
—
—
0
0
26
57
4.65
11.22
1.3
1.1
—
—
—
0
0
26
58
4.57
10.99
1.3
1.1
—
—
—
0
0
26
58
4.57
10.99
1.3
1.1
—
—
—
0
0
26
58
4.57
10.99
1.3
1.1
—
—
—
0
0
44
146
3.10
10.60
1.2
1.3
—
—
—
0
0
425
3189
1.55
10.54
6.3
3.4
2.3
2.3
mmol/l
1.67
374
2730
615
5001
1.53
10.49
6.1
3.1
77.1
55.7
u/l
4.65
586
4563
308
2161
1.59
10.18
2.0
1.8
1130.8
1183.5
nmol/l
0.39
249
1624
45
161
2.87
9.53
1.1
1.1
—
—
—
0
0
171
1050
1.75
9.39
6.3
3.6
—
—
—
0
0
132
755
1.85
9.18
5.3
3.9
119.9
96.8
ng/l
1.49
119
650
78
370
2.19
9.14
2.5
3.6
1.7
1.7
ratio
—
6
35
225
1497
1.63
9.13
33.8
30.3
1.6
1.5
inr
0.27
23
201
79
379
2.17
9.00
2.5
3.6
70.4
75.0
mg/l
0.09
59
318
11
12
9.25
8.99
1.6
1.2
—
—
—
0
0
12
15
8.08
8.87
1.5
2.3
—
—
—
0
0
78
380
2.13
8.56
2.5
3.6
63.9
78.3
mg/l
0.17
57
321
29
86
3.44
8.39
1.0
1.1
—
—
—
0
0
497
3984
1.46
8.35
3.4
2.4
—
—
—
0
0
80
398
2.09
8.32
2.1
2.7
3.4
3.2
g/l
1.22
62
310
137
821
1.77
8.15
3.0
2.4
37.7
34.0
u/l
0.62
125
684
391
3014
1.47
7.95
3.7
3.2
7.1
7.4
mmol/l
0.71
328
2464
516
4191
1.44
7.95
6.8
4.3
—
—
—
0
0
61
281
2.24
7.70
3.4
3.3
0.8
0.8
nmol/l
0.12
49
218
48
199
2.48
7.67
1.4
1.5
—
—
—
0
0
17
36
4.78
7.65
1.2
1.3
33.7
26.8
%
0.27
11
25
99
548
1.89
7.62
8.0
3.1
26.4
25.1
mmol/l
1.74
87
529
42
164
2.62
7.59
1.5
1.4
9729.2
1507.5
e6/l
0.52
32
118
81
426
1.97
7.26
2.1
2.6
3.7
3.8
g/l
0.03
61
306
63
1215
0.49
7.24
8.4
8.4
—
—
—
0
0
81
427
1.97
7.21
2.1
2.6
7.9
7.5
g/l
1.13
63
313
81
427
1.97
7.21
2.1
2.6
—
—
—
0
0
31
108
2.93
6.94
2.8
2.9
—
—
—
0
0
152
979
1.64
6.92
2.7
2.5
13.8
6.4
ug/l
3.58
137
852
236
1690
1.51
6.77
5.1
3.0
0.9
1.1
e6/l
0.61
149
1011
395
3144
1.40
6.41
4.4
4.0
19.3
9.0
mg/mmol
2.02
287
2027
75
402
1.93
6.38
2.2
2.7
10.7
10.4
g/l
0.12
63
336
22
68
3.28
6.02
1.8
1.5
—
—
—
0
0
22
68
3.28
6.02
1.8
1.5
—
—
—
0
0
68
363
1.93
5.87
1.9
2.8
0.8
1.5
g/l
0.60
63
310
25
85
2.99
5.87
1.2
1.3
—
—
—
0
0
10
9
11.20
5.80
1.0
1.2
98.1
59.2
%
—
10
9
10
9
11.20
5.80
1.0
1.2
—
—
—
0
0
19
55
3.50
5.75
1.8
1.4
—
—
—
0
0
19
55
3.50
5.75
1.8
1.4
—
—
—
0
0
40
178
2.30
5.54
1.2
1.3
—
—
—
0
0
17
47
3.66
5.49
1.8
2.1
2477.1
1700.3
u/ml
0.22
17
47
30
122
2.50
5.07
1.1
1.3
—
—
—
0
0
9
9
10.07
5.03
1.2
1.6
119.9
87.7
%
—
9
9
739
6643
1.35
5.02
58.8
21.2
15.0
13.9
%
47.15
728
6491
33
144
2.33
4.81
1.5
1.3
226213.8
101180.4
e6/l
0.47
23
90
19
62
3.10
4.80
1.1
1.2
1.0
1.1
u/ml
—
9
25
39
184
2.16
4.74
1.2
1.2
29.4
43.1
u/l
0.51
34
156
51
270
1.93
4.57
1.4
1.5
257.8
274.4
ug/g
0.21
31
164
498
4275
1.31
4.45
5.5
4.0
0.0
0.0
estimate
0.50
123
776
29
124
2.38
4.44
1.4
1.5
—
—
—
0
0
745
8078
0.75
4.41
5.2
4.8
4.2
4.4
mmol/l
4.45
673
7307
736
7991
0.75
4.37
5.1
4.7
1.3
1.4
mmol/l
4.54
657
7152
29
126
2.34
4.29
1.4
1.6
—
—
—
0
0
29
126
2.34
4.29
1.4
1.5
—
—
—
0
0
7
6
11.73
4.28
2.6
2.0
0.9
1.9
%
—
7
6
309
2495
1.33
4.25
1.9
1.6
17.9
20.3
nmol/l
2.16
286
2100
29
127
2.32
4.22
1.4
1.6
—
—
—
0
0
29
127
2.32
4.22
1.4
1.6
—
—
—
0
0
770
8296
0.75
4.22
5.5
5.4
2.4
2.6
mmol/l
8.83
685
7457
27
115
2.38
4.18
6.0
3.6
53.3
55.4
%
0.17
21
76
11
27
4.11
4.17
6.5
1.8
—
—
—
0
0
29
128
2.30
4.15
1.4
1.5
—
—
—
0
0
488
4205
1.29
4.14
7.5
5.3
0.0
0.0
estimate
0.00
124
799
783
7180
1.33
4.14
52.0
19.2
37.5
38.7
%
2.33
481
4459
192
2490
0.72
4.05
2.4
3.3
0.7
0.8
ug/l
0.60
124
1778
890
8334
1.38
3.99
53.1
17.5
25.8
28.0
mg/l
1.70
862
6836
489
4239
1.28
3.88
5.5
3.9
0.0
0.0
estimate
0.00
123
806
49
276
1.81
3.68
1.4
1.4
—
—
—
0
0
62
379
1.67
3.52
2.0
3.3
4.1
4.3
pmol/l
1.13
51
328
86
571
1.55
3.49
5.2
2.8
0.2
0.3
e6/l
0.67
86
558
24
106
2.29
3.47
1.7
2.3
—
—
—
0
0
8
14
5.75
3.34
16.0
10.1
6.0
6.1
mmol/l
—
8
14
8
14
5.75
3.34
2.8
1.4
47.5
38.6
umol/l
—
8
14
25
115
2.20
3.30
1.4
1.5
61.2
63.1
%
0.09
17
78
469
4108
1.25
3.23
2.4
2.1
92.4
92.3
pmol/l
0.01
258
2177
766
8178
0.78
3.22
5.8
5.1
6.0
6.1
mmol/l
1.12
689
7273
142
1063
1.39
3.14
3.6
4.0
17.8
25.7
ug/l
0.24
125
892
42
239
1.79
3.09
1.5
1.7
11114.7
17417.4
e6/l
0.77
32
170
297
3514
0.79
3.08
3.5
4.8
22.6
21.7
%
0.33
95
1855
193
1531
1.32
2.92
1.3
1.2
1.0
1.5
u/ml
0.74
40
377
722
7727
0.80
2.86
4.8
4.2
1.4
1.3
mmol/l
7.41
650
6860
14
53
2.66
2.80
2.5
1.6
—
—
—
0
0
5
6
8.36
2.75
1.8
1.7
—
—
—
0
0
734
7830
0.81
2.75
41.9
16.5
68.3
73.1
ml/min/173m2
6.27
658
6498
28
150
1.89
2.53
1.2
1.1
—
—
—
0
0
94
683
1.41
2.50
3.0
2.2
12.0
12.0
nmol/l
0.02
81
583
47
297
1.61
2.43
1.5
1.6
—
—
—
0
0
260
2192
1.24
2.41
1.9
1.8
42222716.1
16723211.2
pmol/l
0.26
225
1782
5
8
6.27
2.37
1.0
1.0
—
—
—
0
0
8
22
3.66
2.36
1.3
1.6
21.3
425.1
ug/l
—
8
17
12
46
2.63
2.36
1.0
1.2
110.5
104.1
u/l
0.09
12
39
265
2256
1.23
2.23
3.8
2.5
—
—
—
0
0
8
24
3.35
2.18
1.6
1.3
8.4
9.8
ug/l
—
8
24
14
61
2.31
2.15
1.8
1.2
—
—
—
0
0
14
61
2.31
2.15
1.8
1.2
—
—
—
0
0
11
43
2.57
2.10
1.0
1.2
90.5
24.1
u/l
0.87
11
36
6
15
4.02
2.04
1.0
1.2
—
—
—
0
0
13
272
0.47
2.02
1.4
1.7
—
—
—
0
0
21
374
0.55
1.99
2.0
1.8
—
—
—
0
0
10
40
2.51
1.84
4.6
2.8
—
—
—
0
0
10
40
2.51
1.84
4.6
2.8
—
—
—
0
0
10
40
2.51
1.84
1.1
1.0
—
—
—
0
0
16
301
0.52
1.83
1.4
1.8
—
—
—
0
0
5
13
3.86
1.71
1.0
1.1
—
—
—
0
0
647
6071
1.16
1.67
4.2
3.7
15.0
15.1
pmol/l
0.57
593
5363
51
365
1.42
1.56
1.1
1.2
67.1
159.8
iu/ml
2.44
14
139
12
57
2.12
1.55
1.3
1.1
—
—
—
0
0
6
21
2.87
1.50
1.0
1.3
—
—
—
0
0
7
28
2.51
1.45
1.1
1.2
—
—
—
0
0
32
213
1.52
1.42
1.9
1.6
—
—
—
0
0
14
74
1.90
1.39
1.1
1.0
—
—
—
0
0
6
24
2.51
1.30
1.8
2.2
1.2
1.2
mmol/l
—
6
24
18
106
1.71
1.30
1.2
1.0
—
—
—
0
0
402
4350
0.88
1.26
4.1
5.5
2.2
3.4
ug/l
1.54
344
3847
6
25
2.41
1.24
13.7
2.9
14.8
13.2
%
—
6
25
65
506
1.30
1.22
4.6
2.7
0.6
0.7
%
0.70
65
492
22
140
1.58
1.21
2.5
2.4
25.6
20.4
mg/l
—
8
33
6
26
2.31
1.19
12.5
17.3
1680.5
1659.7
nmol/l
—
6
26
15
87
1.73
1.15
1.9
2.2
1.6
2.2
u/field
—
10
28
8
40
2.01
1.12
1.4
1.2
—
—
—
0
0
46
347
1.34
1.09
8.9
3.3
4.0
4.0
mmol/l
0.43
39
317
20
303
0.65
1.09
1.1
1.0
—
—
—
0
0
8
41
1.96
1.09
1.0
1.2
—
—
—
0
0
12
67
1.80
1.05
1.3
1.4
—
55.0
—
0
8
7
37
1.90
0.94
1.0
1.3
—
—
—
0
0
6
29
2.07
0.89
1.0
1.2
572.8
160.6
iu/ml
—
6
29
17
113
1.51
0.82
2.1
1.5
—
—
—
0
0
347
3255
1.10
0.73
5.8
4.3
—
—
—
0
0
9
57
1.58
0.71
10.2
4.8
—
—
—
0
0
7
41
1.71
0.70
1.0
1.2
—
—
—
0
0
9
58
1.56
0.70
2.0
2.6
—
—
—
0
0
21
152
1.39
0.69
1.9
1.6
3.4
4.9
iu/l
—
8
41
208
1919
1.10
0.62
5.6
4.4
1.0
1.0
kg/l
0.79
48
286
6
104
0.57
0.62
1.2
1.4
—
—
—
0
0
13
88
1.48
0.60
1.6
1.3
9446.0
129087.7
e6/l
—
8
60
0
21
0.00
0.60
0.0
1.1
—
—
—
0
0
6
35
1.72
0.57
1.0
1.1
—
—
—
0
0
6
36
1.67
0.56
1.2
1.2
—
64.4
—
0
5
18
240
0.75
0.56
6.9
3.5
7.0
7.7
mmol/l
1.07
18
234
29
230
1.27
0.55
1.2
1.2
—
—
—
0
0
55
642
0.85
0.54
1.5
1.4
—
—
—
0
0
768
7511
1.08
0.52
5.5
4.6
2.1
2.0
mu/l
0.36
711
6690
6
40
1.50
0.51
8.3
5.6
—
53.3
—
0
7
9
64
1.41
0.51
1.1
3.7
16.2
50.8
u/ml
—
9
64
34
280
1.22
0.49
2.7
3.3
44.3
69.2
u/ml
0.59
34
267
896
8824
1.09
0.48
58.0
21.0
138.9
139.6
mmol/l
12.41
881
8584
27
218
1.24
0.47
1.3
1.3
—
—
—
0
0
8
57
1.41
0.42
2.0
1.9
—
—
—
0
0
0
15
0.00
0.41
0.0
1.1
—
—
—
0
0
179
1908
0.93
0.41
3.2
3.1
2.5
2.5
mmol/l
3.94
142
1669
5
35
1.43
0.39
1.0
1.3
—
—
—
0
0
896
8844
1.08
0.39
58.6
21.1
4.0
4.0
mmol/l
3.58
881
8594
896
9070
0.93
0.38
65.6
25.7
129.3
133.4
g/l
10.95
884
8892
93
853
1.10
0.35
1.4
1.3
—
—
—
0
0
23
191
1.21
0.33
1.4
1.8
43.4
43.3
nmol/l
0.01
23
178
6
46
1.31
0.33
1.0
1.0
—
—
—
0
0
6
47
1.28
0.32
1.5
1.4
1.0
0.9
g/l
—
6
47
13
101
1.29
0.31
1.0
1.1
1.6
45.2
iu/ml
—
5
17
246
2374
1.05
0.24
6.5
4.2
0.0
0.0
estimate
0.50
115
754
0
10
0.00
0.21
0.0
1.1
—
0.2
—
0
5
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
782
7902
0.96
0.21
8.0
6.6
44.0
41.1
mmol/mol
3.83
730
7178
26
230
1.13
0.20
1.2
1.2
—
—
—
0
0
6
48
1.25
0.20
1.0
1.7
13.5
16.0
nmol/l
—
6
42
(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection
6
52
1.15
0.19
1.0
1.1
—
—
—
0
0
10
121
0.82
0.18
2.1
1.4
—
—
—
0
0
8
70
1.14
0.16
1.5
1.2
—
—
—
0
0
23
254
0.90
0.14
5.7
3.4
1.5
1.6
mmol/l
0.32
23
248
20
181
1.11
0.12
1.4
1.7
—
—
—
0
0
884
8794
1.03
0.12
25.8
11.1
24.3
25.1
u/l
0.93
872
8418
32
298
1.08
0.11
1.3
1.3
—
—
—
0
0
41
433
0.94
0.10
1.4
1.4
—
57.1
—
0
23
5
46
1.09
0.09
1.0
1.1
—
—
—
0
0
47
490
0.96
0.08
2.3
2.6
—
12.1
—
0
12
6
72
0.83
0.07
1.3
1.1
—
—
—
0
0
21
225
0.93
0.07
11.2
4.0
34.3
31.2
mg/l
0.10
13
148
7
82
0.85
0.07
1.6
2.1
—
—
—
0
0
69
711
0.97
0.07
3.9
3.2
42.6
59.3
ml/min/173m2
3.17
28
310
115
1169
0.98
0.05
4.6
4.8
32.6
32.7
%
0.02
86
750
226
2246
1.01
0.02
1.8
1.6
1.5
1.3
mmol/l
3.38
204
1838
28
273
1.03
0.01
2.0
2.6
178.0
76.9
ug/min
0.51
20
168
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
5.4
—
—
—
0
0
6
68
0.88
0.00
1.3
2.1
—
—
—
0
0
0
5
0.00
0.00
0.0
8.0
—
74.8
—
0
5
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.5
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint ILD_INSUFFICIENCY and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| ILD_INSUFFICIENCY | 8.21 [6.16, 10.94] | < 0.001 |
| Birth year | 0.996 [0.99, 1.0] | 0.326 |
During the follow-up period (1.1.1998 — 31.12.2019), 1133 out of 1651 females with ILD_INSUFFICIENCY died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| ILD_INSUFFICIENCY | 7.529 [5.54, 10.23] | < 0.001 |
| Birth year | 0.988 [0.98, 1.0] | 0.007 |
During the follow-up period (1.1.1998 — 31.12.2019), 1687 out of 2465 males with ILD_INSUFFICIENCY died.
Mortality risk
Mortality risk for people of age
years, who have ILD_INSUFFICIENCY.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.882% | 1.479% |
| 5 | 5.567% | 7.869% |
| 10 | 12.156% | 19.449% |
| 15 | 22.803% | 33.892% |
| 20 | 37.258% | 52.12% |
Relationships between endpoints
↥Index endpoint: ILD_INSUFFICIENCY – ILD-related respiratory insufficiency
GWS hits: 6
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data