eosinophilic pneumonia: An inflammatory lung disorder characterized by an increased number of eosinophils in the lungs. The majority of cases are idiopathic, without identifiable cause. In a minority of cases, medications, fungal infections, and environmental triggers have been implicated. It manifests as acute or chronic. Acute eosinophilic pneumonia is a severe and rapidly progressing pneumonia that may lead to respiratory failure requiring mechanical ventilation. Chronic eosinophilic pneumonia follows a slower course and manifests as fever, dyspnea, cough, and weight loss.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519972 |
1. Apply sex-specific ruleNone |
519972 |
2. Check conditionsNone |
519972 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
439 |
4. Check minimum number of eventsNone |
439 |
5. Include endpointsNone |
439 |
6. Filter based on genotype QC (FinnGen only) |
425 |
Control definitions (FinnGen only)
- Control exclude
- J10_INTERSTITIUM
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- J80-J84
- Name in latin
- Eosinophilia pulmonum non alibi classificata
Similar endpoints
↥List of similar endpoints to
Pulmonary eosinophilia, not elsewhere classified
based on the number of shared cases.
Similar with more cases:
- Respiratory diseases principally affecting the interstitium, IBD co-morbidites
- Other respiratory diseases principally affecting the interstitium
- Diagnoses used for exclusion with ILD
- Diseases of the respiratory system
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 3168 | 1780 | 1353 |
| Only index persons | 2462 | 1464 | 998 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.05 | 0.05 | 0.04 |
| Only index persons | 0.05 | 0.05 | 0.04 |
| Median age at first event (years) | |||
| Whole population | 59.21 | 58.03 | 60.60 |
| Only index persons | 56.56 | 55.95 | 57.46 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 425 | 237 | 188 |
| Unadjusted period prevalence (%) | 0.08 | 0.08 | 0.09 |
| Median age at first event (years) | 57.73 | 54.32 | 62.03 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 439
- Matched controls
- 4390
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
J82
ICD-10 Finland
Pulmonary eosinophilia, not elsewhere classified
+∞
307.7
385
*
TGC00
NOMESCO Finland
Bronchial lavation
37.9
152.6
98
33
UGC12
NOMESCO Finland
Flexible bronchoscopy
12.5
127.1
152
179
J45.1
ICD-10 Finland
Nonallergic asthma
11.2
107.3
134
165
GD1DD
NOMESCO Finland
High resolution CT examination of lungs
15.9
107.2
101
81
H02AB06
ATC
prednisolone; systemic
15.1
103.2
393
1585
J45.0
ICD-10 Finland
Predominantly allergic asthma
9.5
94.8
136
198
R91
ICD-10 Finland
Abnormal findings on diagnostic imaging of lung
8.4
92.0
153
264
203
Kela drug reimbursment
Chronic asthma and similar chronic obstructive pulmonary diseases
7.0
91.7
221
557
J45.9
ICD-10 Finland
Asthma, unspecified
6.6
85.2
209
530
J18.9
ICD-10 Finland
Pneumonia, unspecified
6.2
81.5
254
794
NK6QA
NOMESCO Finland
Measurement of bone density from two or more locations with X-ray
8.0
60.4
93
143
R03DC03
ATC
montelukast; oral
5.5
60.1
158
410
J15.9
ICD-10 Finland
Bacterial pneumonia, unspecified
6.0
52.1
109
228
J84.9
ICD-10 Finland
Interstitial pulmonary disease, unspecified
+∞
50.0
47
*
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
4.3
49.8
267
1164
J33.0
ICD-10 Finland
Polyp of nasal cavity
11.3
49.7
55
55
J01MA14
ATC
moxifloxacin; systemic
5.8
49.3
107
231
R03AK08
ATC
formoterol and beclometasone; inhalant
9.1
48.6
64
81
DM1QA
NOMESCO Finland
Paranasal sinuses X-ray examination in one projection
8.7
48.0
66
88
L04AX01
ATC
azathioprine; systemic
10.3
44.8
53
58
5183A
ICD-9 Finland
Other diseases of lung, Pulmonary eosinophilia
+∞
44.5
42
*
DM1AA
NOMESCO Finland
Paranasal sinuses X-ray examination without contrast
9.9
43.7
53
60
R03AK06
ATC
salmeterol and fluticasone; inhalant
4.4
42.9
140
420
J84.8
ICD-10 Finland
Other specified interstitial pulmonary diseases
+∞
41.3
39
*
M05BA04
ATC
alendronic acid; oral
5.1
40.5
102
248
R03BA02
ATC
budesonide; inhalant
4.1
40.4
154
515
D72.1
ICD-10 Finland
Eosinophilia
60.9
38.1
44
8
R03BA08
ATC
ciclesonide; inhalant
5.3
37.9
87
195
GD1ED
NOMESCO Finland
Extensive high resolution CT examination of lungs
9.6
37.3
46
53
R03AC02
ATC
salbutamol; inhalant
3.9
37.2
324
1828
J46
ICD-10 Finland
Status asthmaticus
9.7
36.9
45
51
R03DA04
ATC
theophylline; systemic, rectal
6.0
36.3
71
137
R03BA01
ATC
beclometasone; inhalant
4.2
36.1
123
376
DMB20
NOMESCO Finland
Functional endoscopic opening of maxillary antrum
6.6
36.0
63
109
TDM10
NOMESCO Finland
Puncture of maxillary antrum
7.9
35.1
51
72
51920
ICD-8 Finland
Other diseases of respiratory system, Infiltratio pulmonis eosinophilica
+∞
33.8
32
*
R03AC13
ATC
formoterol; inhalant
6.0
33.6
65
124
R03BB04
ATC
tiotropium bromide; inhalant
4.3
32.4
100
283
H02AB04
ATC
methylprednisolone; systemic
3.9
32.1
118
378
XG410
NOMESCO Finland
Flow-volume spirometry
7.4
31.2
48
72
49300
ICD-8 Finland
Asthma, bronchiale
9.2
31.0
39
46
J33.8
ICD-10 Finland
Other polyp of sinus
10.0
30.4
36
39
XG412
NOMESCO Finland
Flow-volume spirometry with bronchospasmolysis
5.9
29.8
58
111
J32.0
ICD-10 Finland
Chronic maxillary sinusitis
4.8
28.7
72
172
GD1AA
NOMESCO Finland
Thorax X-ray examination
3.1
28.5
277
1567
J45.8
ICD-10 Finland
Mixed asthma
7.7
28.0
41
58
J47
ICD-10 Finland
Bronchiectasis
10.3
27.1
31
32
J84.1
ICD-10 Finland
Other interstitial pulmonary diseases with fibrosis
287.8
27.0
27
*
H02AB07
ATC
prednisone; oral
3.5
26.5
112
390
R03BA05
ATC
fluticasone; inhalant
3.3
26.3
129
492
R03AC12
ATC
salmeterol; inhalant
5.3
26.0
56
117
DNB20
NOMESCO Finland
Endoscopic ethmoidectomy
8.3
25.0
34
44
R01AD05
ATC
budesonide; nasal
4.5
25.0
68
173
J01FA06
ATC
roxithromycin; oral
2.8
24.9
238
1303
R03AK07
ATC
formoterol and budesonide; inhalant
3.1
24.8
133
533
J01MA12
ATC
levofloxacin; systemic
3.1
23.7
131
533
DM1AD
NOMESCO Finland
CT of paranasal sinuses and face area
7.0
23.4
37
57
J45
ICD-10 Finland
Asthma
3.8
22.2
76
228
A02BC02
ATC
pantoprazole; systemic
3.0
20.3
345
2421
R03AK11
ATC
formoterol and fluticasone; inhalant
7.4
20.2
30
43
GCA98
NOMESCO Finland
Other bronchoscopic procedure on bronchus
37.7
20.0
25
7
R03AC03
ATC
terbutaline; inhalant
3.2
19.8
92
335
R01AD08
ATC
fluticasone; nasal
2.6
18.7
159
796
R01AD09
ATC
mometasone; nasal
2.4
17.5
232
1408
J32.4
ICD-10 Finland
Chronic pansinusitis
15.9
16.9
27
18
M30.1
ICD-10 Finland
Polyarteritis with lung involvement [Churg-Strauss]
93.7
16.7
18
*
XG470
NOMESCO Finland
Measurement of diffusion capastity of the lungs
6.3
16.2
28
47
J31.0
ICD-10 Finland
Chronic rhinitis
3.7
16.1
56
169
GD1AD
NOMESCO Finland
Thorax CT examination
4.0
15.4
47
129
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
2.2
15.0
253
1661
R96
ICPC
Asthma
3.1
14.8
68
244
H02AB09
ATC
hydrocortisone; systemic
6.6
14.7
24
38
UDH02
NOMESCO Finland
Rhinopharyngoscopy
3.5
14.6
53
164
R03AK10
ATC
vilanterol and fluticasone furoate; inhalant
4.3
14.4
39
98
J01FA15
ATC
telithromycin; oral
3.2
14.3
62
215
M05BA07
ATC
risedronic acid; oral
4.7
14.0
33
74
WW200
NOMESCO Finland
Immunization
6.3
14.0
24
40
Z01.8
ICD-10 Finland
Other specified special examinations
2.3
13.0
124
638
GD1BD
NOMESCO Finland
Thorax extensive CT-examination
3.6
12.8
44
131
J01FA10
ATC
azithromycin; systemic
2.1
12.8
264
1831
J01.0
ICD-10 Finland
Acute maxillary sinusitis
2.3
12.7
123
636
M81.4
ICD-10 Finland
Drug-induced osteoporosis
33.1
12.7
16
5
R06AE07
ATC
cetirizine; oral
2.1
12.4
201
1270
XG474
NOMESCO Finland
Exhalation nntrogen oxide
4.9
12.0
27
58
R81
ICPC
Pneumonia
4.5
11.7
29
68
DHB20
NOMESCO Finland
Polypectomy of internal nose
9.6
11.6
23
25
FB1BD
NOMESCO Finland
Extensive CT examination of arteria pulmonalis
3.1
11.5
52
184
R06.0
ICD-10 Finland
Dyspnoea
2.1
11.3
147
850
Z3231
NOMESCO Finland
Registered nurse
2.1
11.1
146
848
DM1AI
NOMESCO Finland
Cone beam CT of paranasal sinus
5.6
11.0
21
39
J20.9
ICD-10 Finland
Acute bronchitis, unspecified
2.2
10.9
108
561
GD1CD
NOMESCO Finland
Thorax extensive CT-examination
18.4
10.8
16
9
R03DC01
ATC
zafirlukast; oral
8.3
10.7
23
29
M05BB03
ATC
alendronic acid and colecalciferol; oral
5.0
10.6
23
48
J01FA09
ATC
clarithromycin; systemic
2.0
10.6
153
916
R06.2
ICD-10 Finland
Wheezing
3.8
10.6
33
92
DPA30
NOMESCO Finland
Sphenotomy
14.7
10.6
17
12
S81.8
ICD-10 Finland
Open wound of other parts of lower leg
4.4
10.5
27
65
R06AX27
ATC
desloratadine; oral
2.1
10.4
124
691
TGD04
NOMESCO Finland
Needle biopsy of the lungs in bronchoscopy
33.4
10.4
13
*
L04AA06
ATC
mycophenolic acid; systemic
9.9
10.4
20
21
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
2.3
10.3
90
442
R05
ICD-10 Finland
Cough
2.2
10.1
107
568
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
2.2
9.9
101
529
R01AD01
ATC
beclometasone; nasal
2.3
9.7
85
417
R03BB01
ATC
ipratropium bromide; inhalant
3.4
9.5
36
114
XQ800
NOMESCO Finland
Prick test
3.0
9.5
43
152
R03AL09
ATC
formoterol, glycopyrronium bromide and beclometasone; inhalant
4.4
9.5
24
57
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
2.4
9.5
70
319
J01AA02
ATC
doxycycline; systemic
2.2
9.4
359
2944
R01AD12
ATC
fluticasone furoate; nasal
2.0
9.4
135
802
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
2.5
9.3
62
269
J01CA04
ATC
amoxicillin; systemic
2.2
9.3
356
2916
J90
ICD-10 Finland
Pleural effusion, not elsewhere classified
3.8
9.3
29
81
A02BC01
ATC
omeprazole; systemic
1.9
9.0
143
877
4859X
ICD-9 Finland
Bronchopneumonia, organism unspecified[PNEUMONIA NUD]
7.1
8.9
21
31
1240
FHL
Bronchoscopy
8.2
8.9
19
24
4930A
ICD-9 Finland
Asthma, Extrinsic asthma[EXTRINSIC ASTHMA SINE EXACERBATIONE]
14.4
8.7
14
10
J22
ICD-10 Finland
Unspecified acute lower respiratory infection
3.2
8.7
36
121
R01BA52
ATC
pseudoephedrine, combinations; oral
1.9
8.7
144
894
GX1L5
NOMESCO Finland
Exhaled nitric oxide analysis
16.7
8.6
13
8
E27.3
ICD-10 Finland
Drug-induced adrenocortical insufficiency
20.5
8.5
12
6
J01MA02
ATC
ciprofloxacin; systemic
1.8
8.5
188
1277
297, ,
Kela drug reimbursment
+∞
8.4
8
*
A07AA02
ATC
nystatin; oral
2.9
8.3
39
141
J96.1
ICD-10 Finland
Chronic respiratory failure
4.9
8.2
18
38
J02AC03
ATC
voriconazole; systemic
34.0
8.1
10
*
ZXA10
NOMESCO Finland
Bilateral
2.0
7.9
100
563
N17.9
ICD-10 Finland
Acute renal failure, unspecified
3.5
7.8
27
81
E0000UV, ,
ATC
1.8
7.7
184
1268
M05BX04
ATC
denosumab; parenteral
2.9
7.7
37
136
DPA25
NOMESCO Finland
Trephine of frontal sinus through nose
10.3
7.6
14
14
127
Kela drug reimbursment
Transplant complication
10.3
7.6
14
14
R02
ICPC
Shortness of breath/dyspnoea
2.2
7.6
69
343
P01BA02
ATC
hydroxychloroquine; oral
2.5
7.5
48
204
K51.9
ICD-10 Finland
Ulcerative colitis, unspecified
4.5
7.5
18
41
3028
Kela drug reimbursment
Mepolizumab
81.4
7.4
8
*
ZX120
NOMESCO Finland
Intravenous
2.3
7.4
56
258
J84.0
ICD-10 Finland
Alveolar and parietoalveolar conditions
+∞
7.3
7
*
R03DX09
ATC
mepolizumab; parenteral
+∞
7.3
7
*
Z3226
NOMESCO Finland
Physiotherapist
2.0
7.3
93
525
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
2.3
7.3
57
266
WZC30
NOMESCO Finland
Teaching
2.1
7.2
80
430
R50.9
ICD-10 Finland
Fever, unspecified
2.1
7.1
74
387
L95
ICPC
Osteoporosis
3.3
7.1
27
86
K51.5
ICD-10 Finland
Left sided colitis
4.5
7.0
17
39
J01EE01
ATC
sulfamethoxazole and trimethoprim; systemic
2.8
6.9
34
126
ZXE00
NOMESCO Finland
One hour or less
1.7
6.9
169
1165
J01DA06
ATC
[U] cefuroxime
2.0
6.8
76
408
251, ,
Kela drug reimbursment
40.7
6.8
8
*
3027
Kela drug reimbursment
Benralizumab
40.7
6.8
8
*
B44.1
ICD-10 Finland
Other pulmonary aspergillosis
40.7
6.8
8
*
R03DX10
ATC
benralizumab; systemic
40.7
6.8
8
*
4931B
ICD-9 Finland
Asthma, Intrinsic asthma[INTRINSIC ASTHMA CUM EXACERBATIONE]
17.0
6.8
10
6
R01AD58
ATC
fluticasone, combinations; nasal
1.9
6.7
97
570
4939X
ICD-9 Finland
Asthma, unspecified[ASTHMA BRONCHIALE NUD]
6.6
6.7
16
25
H53.1
ICD-10 Finland
Subjective visual disturbances
2.8
6.6
34
129
SPAT1255
SPAT
Intravenous administration of medicine
2.7
6.6
36
141
4930B
ICD-9 Finland
Asthma, Extrinsic asthma[EXTRINSIC ASTHMA CUM EXACERBATIONE]
10.2
6.6
12
12
SPAT1083
SPAT
Initiation and monitoring of IV fluid therapy
3.1
6.5
27
91
50301
ICD-8 Finland
Chronic sinusitis, Maxillaris NUD
7.6
6.5
14
19
Z94.2
ICD-10 Finland
Lung transplant status
70.8
6.4
7
*
A02BC05
ATC
esomeprazole; systemic
1.7
6.4
186
1336
UDM02
NOMESCO Finland
Sinoscopy
4.2
6.4
17
42
J01FF01
ATC
clindamycin; systemic
1.8
6.3
125
807
Z2221
NOMESCO Finland
Medical doctor
1.8
6.2
123
794
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
2.0
6.2
77
429
5BA08, ,
NOMESCO Finland
12.8
6.1
10
8
WX872
NOMESCO Finland
Intensive care
2.9
6.1
29
106
R03AL02
ATC
salbutamol and ipratropium bromide; inhalant
6.8
6.1
14
21
J32.9
ICD-10 Finland
Chronic sinusitis, unspecified
10.2
6.1
11
11
L04AD01
ATC
ciclosporin; systemic
6.2
6.0
15
25
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
99
100
12.49
90.44
1.9
1.6
568.00
116.67
titre
—
5
6
118
199
7.74
71.12
2.6
1.2
390.86
227.30
u/ml
0.98
111
180
78
109
8.49
54.80
2.8
2.9
—
—
—
0
0
40
20
21.90
52.68
1.9
1.1
4.98
0.15
u/ml
—
30
10
64
75
9.82
51.64
1.5
1.3
—
—
—
0
0
327
1799
4.20
40.42
13.9
5.5
0.33
0.19
e9/l
20.81
312
1583
305
1640
3.82
38.09
12.3
5.3
58.86
57.15
%
1.80
298
1531
303
1625
3.79
37.93
13.0
5.3
4.34
2.83
%
11.09
298
1508
303
1661
3.66
35.85
13.2
5.5
24.40
27.70
%
6.66
298
1548
333
2010
3.72
32.29
14.7
8.9
4.93
4.01
e9/l
6.24
316
1761
40
58
7.49
26.75
1.8
1.5
—
—
—
0
0
35
48
7.84
24.52
1.8
1.6
—
—
—
0
0
38
60
6.84
23.48
2.1
1.7
—
—
—
0
0
44
82
5.85
23.09
2.1
1.6
—
—
—
0
0
43
79
5.93
22.90
2.2
1.6
—
—
—
0
0
34
52
7.00
21.61
2.1
1.5
—
—
—
0
0
34
52
7.00
21.61
2.1
1.5
—
—
—
0
0
29
39
7.89
20.60
4.1
3.9
—
—
—
0
0
238
1439
2.43
18.42
2.9
2.2
83.55
78.30
nmol/l
1.73
229
1262
27
39
7.31
18.01
1.8
1.6
—
—
—
0
0
29
46
6.68
17.78
1.9
1.6
—
—
—
0
0
29
22
14.03
17.21
2.0
1.6
—
—
—
0
0
30
53
6.00
16.56
1.9
1.6
—
—
—
0
0
25
37
7.10
16.30
2.0
1.4
—
—
—
0
0
25
37
7.10
16.30
2.0
1.4
—
—
—
0
0
24
34
7.41
16.26
2.3
1.6
—
—
—
0
0
83
319
2.98
16.08
2.3
2.0
313.17
370.80
nmol/l
0.54
77
284
42
107
4.23
15.23
1.5
1.7
—
—
—
0
0
25
42
6.25
14.48
1.1
1.2
—
—
—
0
0
32
68
5.00
14.47
1.0
1.1
—
—
—
0
0
27
50
5.69
14.18
10.4
4.8
170.80
139.80
iu/ml
—
5
5
122
607
2.40
13.94
2.5
1.8
—
—
—
0
0
38
96
4.24
13.92
1.9
1.5
—
—
—
0
0
24
20
12.62
13.75
1.1
1.1
—
—
—
0
0
41
112
3.93
13.53
1.2
1.2
0.35
0.19
u/ml
—
6
10
345
2636
2.44
13.43
8.8
4.0
14.55
12.38
mm/h
2.21
337
2423
27
54
5.26
13.06
1.7
1.6
—
—
—
0
0
19
11
17.99
12.62
1.6
1.2
—
—
—
0
0
94
433
2.49
12.60
2.1
1.7
—
—
—
0
0
258
1795
2.06
12.14
8.7
6.1
1.22
1.22
mmol/l
0.20
232
1529
93
436
2.44
11.96
2.2
1.8
—
—
—
0
0
27
59
4.81
11.81
6.4
3.9
56.59
58.49
%
0.23
27
59
24
30
8.40
11.23
2.3
1.7
—
—
—
0
0
349
2767
2.27
11.05
11.4
7.3
75.86
79.70
u/l
1.19
337
2579
238
1651
1.96
10.82
7.3
5.5
1.21
1.21
mmol/l
0.01
229
1494
267
1937
1.97
10.52
6.7
5.9
10.51
11.22
umol/l
0.84
259
1832
62
258
2.63
10.16
1.7
1.6
—
—
—
0
0
15
9
17.19
9.94
3.6
1.3
39.73
87.78
ug/l
—
15
9
27
70
4.04
9.55
1.3
1.4
—
—
—
0
0
86
434
2.22
9.17
7.8
4.6
1.02
1.01
mmol/l
0.17
81
390
27
73
3.88
9.03
1.4
2.0
123.88
130.12
g/l
0.46
17
57
32
100
3.37
8.67
1.7
1.5
1.28
0.01
iu/ml
—
8
16
26
71
3.83
8.58
1.1
1.1
—
—
—
0
0
129
775
1.94
8.56
2.0
1.6
1.04
1.11
mg/l
0.22
101
609
19
41
4.80
8.43
1.1
1.1
—
—
—
0
0
102
567
2.04
8.43
3.0
2.2
13.08
12.74
umol/l
0.14
94
521
17
24
7.32
7.55
1.0
1.1
—
—
—
0
0
138
889
1.81
7.17
2.7
2.1
3.15
3.18
mg/l
0.04
123
759
49
216
2.43
7.09
4.2
2.6
1.60
1.88
mmol/l
0.21
38
158
149
986
1.77
7.06
4.0
3.1
0.25
0.46
e6/l
1.08
120
738
184
1293
1.73
7.05
4.7
3.1
—
—
—
0
0
272
2139
1.71
6.79
5.9
4.5
6.68
6.71
mmol/l
0.11
262
2007
18
33
5.64
6.68
1.9
1.6
—
—
—
0
0
18
33
5.64
6.68
1.9
1.6
—
—
—
0
0
18
33
5.64
6.68
1.9
1.6
—
—
—
0
0
24
74
3.37
6.65
1.3
1.4
—
—
—
0
0
11
9
12.50
6.61
1.9
1.9
—
—
—
0
0
11
9
12.50
6.61
1.9
1.9
—
—
—
0
0
90
519
1.92
6.58
3.0
2.2
2.25
2.31
g/l
0.44
83
475
55
264
2.24
6.56
3.5
3.3
89.53
79.37
ng/l
0.40
46
231
158
1084
1.71
6.48
4.1
3.2
83.82
134.35
e6/l
0.23
131
833
87
499
1.93
6.45
3.1
2.2
22.71
22.20
%
0.12
77
425
62
316
2.12
6.37
3.2
3.1
239.39
208.18
ng/l
0.18
56
289
11
10
11.24
6.33
2.0
1.8
—
—
—
0
0
115
726
1.79
6.29
4.2
3.9
205.97
227.64
ng/l
0.08
97
591
163
1138
1.69
6.22
3.8
3.2
27.42
31.76
u/l
2.71
156
1082
117
746
1.77
6.18
3.3
2.6
3.75
4.94
e6/l
0.67
110
681
23
74
3.22
5.98
1.3
1.4
—
—
—
0
0
246
1925
1.63
5.89
3.3
2.7
—
—
—
0
0
18
50
3.71
5.82
1.2
1.3
—
—
—
0
0
11
12
9.37
5.82
2.8
6.3
—
—
—
0
0
17
36
4.87
5.67
1.2
1.1
0.16
1.72
u/ml
—
8
17
208
1574
1.61
5.63
7.1
4.3
33.89
35.36
g/l
3.30
197
1462
11
13
8.65
5.59
1.6
1.8
—
—
—
0
0
95
588
1.79
5.49
1.4
1.3
19.14
35.73
iu/ml
2.01
28
193
91
558
1.80
5.42
1.4
1.3
12.22
11.90
u/ml
0.02
29
217
191
1426
1.60
5.40
3.2
2.6
133.20
130.62
ug/l
0.06
176
1301
12
18
6.82
5.28
1.6
1.7
—
—
—
0
0
11
15
7.49
5.17
1.9
1.6
—
—
—
0
0
11
15
7.49
5.17
1.9
1.6
—
—
—
0
0
227
1780
1.57
5.11
18.3
14.5
1.26
1.27
inr
0.05
68
508
12
19
6.46
5.11
1.6
1.7
—
—
—
0
0
168
1243
1.57
4.80
4.4
3.2
2.34
2.35
mmol/l
0.33
155
1093
8
7
11.61
4.80
3.1
1.4
—
—
—
0
0
12
23
5.33
4.48
1.6
1.7
—
—
—
0
0
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
25
102
2.54
4.29
3.1
2.2
0.28
0.36
u/ml
0.89
18
58
86
557
1.68
4.17
5.2
3.2
0.82
0.81
mmol/l
0.23
81
515
15
47
3.27
4.09
1.1
1.3
—
—
—
0
0
19
70
2.79
3.97
2.2
2.3
14.63
15.88
%
0.64
12
35
68
423
1.72
3.82
6.9
7.1
1.77
1.31
mmol/l
0.37
55
344
153
1157
1.49
3.77
4.8
3.1
1629.28
1365.12
ng/l
0.38
141
990
6
5
12.14
3.77
1.2
1.0
—
—
—
0
0
13
34
3.91
3.72
1.2
1.1
—
—
—
0
0
12
30
4.08
3.62
1.8
1.2
—
—
—
0
0
12
30
4.08
3.62
1.8
1.2
—
—
—
0
0
11
26
4.31
3.53
1.1
1.1
—
—
—
0
0
11
26
4.31
3.53
1.1
1.1
—
—
—
0
0
12
31
3.95
3.51
1.7
1.7
—
—
—
0
0
11
27
4.15
3.41
1.1
1.1
—
—
—
0
0
11
27
4.15
3.41
1.1
1.1
—
—
—
0
0
11
27
4.15
3.41
1.1
1.1
—
—
—
0
0
13
42
3.16
3.39
1.2
1.1
—
—
—
0
0
8
14
5.80
3.35
1.0
1.1
—
—
—
0
0
11
28
4.00
3.31
1.0
1.0
—
—
—
0
0
30
150
2.07
3.29
2.5
1.7
—
—
—
0
0
83
565
1.58
3.27
3.5
2.9
0.73
2.29
e6/l
3.17
51
298
86
592
1.56
3.23
3.3
2.7
0.49
1.12
e6/l
2.30
54
322
19
79
2.47
3.18
1.2
1.2
—
—
—
0
0
380
3499
1.64
3.14
28.6
14.5
22.97
24.03
mg/l
0.29
355
2783
54
333
1.71
3.14
6.0
3.0
3.02
2.17
mmol/l
0.50
46
274
29
149
2.01
2.97
1.2
1.9
—
—
—
0
0
272
2357
1.40
2.96
6.0
4.5
2146.60
2454.79
e6/l
—
5
47
40
230
1.81
2.95
1.8
1.6
—
—
—
0
0
144
1121
1.42
2.93
2.7
2.1
105.62
224.74
u/l
4.27
138
1055
6
9
6.74
2.87
1.2
1.6
—
—
—
0
0
26
131
2.05
2.82
2.6
2.1
135.62
310.94
ug/l
1.61
26
122
5
6
8.41
2.75
1.4
1.7
—
—
—
0
0
6
10
6.06
2.70
1.0
1.1
—
—
—
0
0
12
42
2.91
2.56
1.5
1.7
30.92
33.12
pg
0.83
12
42
143
1138
1.38
2.50
2.8
2.4
58.28
61.29
u/l
0.20
138
1052
120
928
1.40
2.49
4.0
2.5
12349.58
8342.83
umol/l
0.22
111
798
26
140
1.91
2.37
2.2
1.6
—
—
—
0
0
12
47
2.60
2.29
1.2
1.2
—
—
—
0
0
138
1108
1.36
2.25
4.0
3.0
6.73
7.23
mmol/l
0.88
119
902
204
1739
1.32
2.21
6.4
5.1
0.00
0.00
estimate
-0.00
45
321
94
712
1.41
2.18
1.4
1.2
0.58
1.46
u/ml
1.71
18
191
204
1742
1.32
2.18
4.7
3.8
0.00
0.00
estimate
0.50
48
350
6
14
4.33
2.15
1.0
1.1
—
—
—
0
0
20
102
2.01
2.14
2.3
1.5
—
—
—
0
0
205
1756
1.31
2.12
4.7
3.8
0.00
0.00
estimate
-0.00
44
311
21
113
1.90
1.95
1.6
1.4
243.40
294.46
ug/g
—
10
64
11
45
2.48
1.94
1.2
1.1
2.40
4.11
u/ml
—
5
19
16
78
2.09
1.93
2.0
1.5
—
—
—
0
0
176
1496
1.29
1.87
2.1
2.0
97.56
94.83
pmol/l
0.36
87
745
8
28
2.89
1.87
2.1
2.8
13.82
13.21
%
—
8
28
19
101
1.92
1.83
1.4
1.2
—
—
—
0
0
92
716
1.36
1.81
2.8
3.0
2.48
2.45
mmol/l
1.65
83
629
56
406
1.43
1.67
2.4
2.7
5.76
8.60
umol/l
1.52
49
357
6
19
3.19
1.66
1.5
2.4
514.67
732.95
u/ml
—
6
19
8
31
2.61
1.66
2.5
2.0
—
—
—
0
0
10
42
2.41
1.62
2.0
1.3
—
—
—
0
0
173
1489
1.27
1.62
5.3
3.8
29.23
59.73
ng/l
0.73
127
1085
6
20
3.03
1.58
1.0
1.8
—
—
—
0
0
6
20
3.03
1.58
1.0
1.8
—
—
—
0
0
108
885
1.29
1.48
1.5
1.6
21.36
21.36
nmol/l
0.00
96
742
290
2668
1.26
1.46
4.3
3.9
15.10
14.86
pmol/l
0.90
269
2384
16
89
1.83
1.39
2.6
2.7
1.67
1.63
mg/l
0.08
16
77
19
112
1.73
1.37
1.4
1.1
—
—
—
0
0
6
23
2.63
1.37
2.3
1.3
—
—
—
0
0
113
946
1.26
1.30
1.9
1.7
1.31
1.34
mmol/l
0.19
97
793
15
85
1.79
1.24
1.5
1.3
—
—
—
0
0
88
720
1.28
1.22
1.8
1.7
1108.02
1215.01
nmol/l
0.70
72
544
31
438
0.69
1.22
14.8
7.7
—
—
—
0
0
19
117
1.65
1.20
1.3
4.3
39.93
120.16
mg/l
0.81
12
92
6
26
2.33
1.19
7.8
3.7
—
—
—
0
0
246
2252
1.21
1.19
3.6
3.0
79.84
50.38
u/l
1.31
237
2082
5
20
2.52
1.15
1.0
1.1
—
—
—
0
0
7
30
2.35
1.13
1.0
1.3
—
—
—
0
0
31
219
1.45
1.10
1.5
1.4
—
—
—
0
0
18
113
1.62
1.07
1.4
1.1
—
—
—
0
0
25
171
1.49
1.05
1.3
1.3
—
—
—
0
0
7
34
2.08
1.03
1.3
1.4
—
—
—
0
0
43
327
1.35
1.02
2.8
2.3
24.81
34.90
u/l
1.65
36
270
0
29
0.00
0.98
0.0
1.0
—
656.80
—
0
20
0
29
0.00
0.98
0.0
1.0
—
38.02
—
0
19
342
3564
0.82
0.96
5.5
5.2
2.70
2.72
mmol/l
0.16
322
3253
334
3488
0.82
0.96
5.0
4.6
4.74
4.65
mmol/l
0.75
317
3206
58
466
1.28
0.95
1.5
1.4
—
—
—
0
0
18
117
1.56
0.95
1.3
4.3
26.53
31.24
mg/l
0.41
11
93
338
3222
1.21
0.94
5.3
4.7
1.88
2.35
mu/l
0.66
314
2908
320
3347
0.84
0.88
4.3
4.1
1.23
1.29
mmol/l
1.10
296
3035
128
1130
1.19
0.87
4.7
3.7
4.18
7.77
mg/mmol
1.91
86
690
15
97
1.57
0.82
1.4
1.3
—
—
—
0
0
17
115
1.50
0.78
1.2
4.2
—
2.51
—
0
12
7
38
1.86
0.74
1.6
2.1
—
—
—
0
0
150
1361
1.16
0.72
5.0
4.0
—
—
—
0
0
5
26
1.93
0.71
1.0
1.2
—
—
—
0
0
5
26
1.93
0.71
1.2
1.1
—
—
—
0
0
334
3461
0.85
0.70
4.9
4.5
1.63
1.49
mmol/l
6.37
314
3156
5
27
1.86
0.68
1.0
1.1
—
—
—
0
0
343
3307
1.17
0.67
6.4
6.0
40.57
40.29
mmol/mol
0.20
325
3069
36
287
1.28
0.66
3.3
2.7
60.62
61.39
ml/min/173m2
0.06
21
112
344
3319
1.17
0.66
21.1
13.9
76.53
77.59
ml/min/173m2
0.41
314
2735
10
62
1.63
0.65
4.3
2.8
105.30
105.56
mmol/l
—
10
62
20
146
1.39
0.65
1.1
1.0
—
—
—
0
0
51
427
1.22
0.62
2.4
4.2
139.40
43.67
ug/l
0.31
45
358
8
49
1.64
0.62
1.1
1.0
—
—
—
0
0
0
20
0.00
0.60
0.0
1.6
—
—
—
0
0
0
22
0.00
0.59
0.0
1.2
—
—
—
0
0
59
509
1.18
0.54
1.5
1.5
—
—
—
0
0
106
958
1.14
0.54
5.0
4.1
0.00
0.00
estimate
0.50
44
318
11
75
1.48
0.51
2.9
1.5
3.22
6.37
iu/l
—
5
24
23
181
1.29
0.49
3.4
2.3
0.71
0.65
%
0.38
23
181
41
350
1.19
0.44
1.8
1.8
1.45
1.49
%
0.16
34
303
5
31
1.62
0.43
1.0
1.5
—
53.33
—
0
6
0
18
0.00
0.40
0.0
1.2
—
166.59
—
0
18
23
187
1.24
0.39
3.4
2.3
1.15
1.15
%
0.01
23
187
105
1133
0.90
0.38
4.8
5.0
1.69
2.58
ug/l
1.90
97
998
10
72
1.40
0.37
3.3
1.8
—
—
—
0
0
12
90
1.34
0.36
3.0
1.8
—
—
—
0
0
43
378
1.15
0.34
4.5
3.5
—
—
—
0
0
6
46
1.31
0.33
1.2
1.1
—
—
—
0
0
11
83
1.33
0.32
1.7
1.4
—
—
—
0
0
12
92
1.31
0.32
1.6
1.4
—
—
—
0
0
172
1642
1.08
0.30
3.1
2.5
—
—
—
0
0
84
781
1.09
0.28
5.3
4.1
1.01
1.02
kg/l
0.90
13
108
90
840
1.09
0.28
3.2
2.2
—
—
—
0
0
9
72
1.26
0.26
1.0
1.3
4485.67
1542.86
e6/l
—
9
63
9
72
1.26
0.26
1.0
1.2
141.67
5.00
e6/l
—
9
60
341
3468
0.93
0.25
4.8
4.7
5.79
6.00
mmol/l
2.62
320
3144
83
777
1.08
0.24
1.7
1.8
403.49
448.77
pmol/l
1.02
73
646
6
83
0.72
0.24
1.0
1.3
41.80
26.89
iu/l
—
6
72
5
38
1.32
0.23
1.2
1.2
—
—
—
0
0
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
1.3
—
—
—
0
0
0
10
0.00
0.21
0.0
1.7
—
1.26
—
0
10
0
12
0.00
0.21
0.0
1.1
—
—
—
0
0
0
12
0.00
0.21
0.0
1.1
—
—
—
0
0
0
12
0.00
0.21
0.0
1.1
—
—
—
0
0
0
12
0.00
0.21
0.0
1.1
—
—
—
0
0
6
48
1.25
0.20
7.3
5.5
383.83
372.42
umol/l
—
6
40
0
14
0.00
0.20
0.0
1.3
—
—
—
0
0
0
14
0.00
0.20
0.0
1.0
—
—
—
0
0
388
3840
1.09
0.20
38.8
21.5
39.38
40.00
%
1.09
362
3576
36
327
1.11
0.20
2.9
2.5
6.86
7.07
ug/l
0.03
30
287
21
239
0.87
0.20
2.2
1.7
—
—
—
0
0
60
642
0.92
0.20
3.0
3.0
0.69
0.80
ug/l
0.56
45
419
19
217
0.87
0.19
1.1
1.2
99.92
142.72
iu/ml
—
10
85
43
462
0.92
0.16
4.0
4.5
35.09
32.20
%
1.20
35
304
11
92
1.20
0.16
1.2
1.7
—
—
—
0
0
8
72
1.11
0.16
1.0
1.2
3.64
3.91
mmol/l
—
8
67
6
76
0.79
0.15
3.2
1.6
49.00
42.14
nmol/l
—
6
71
86
897
0.95
0.14
4.3
4.5
21.90
21.38
%
0.15
40
433
14
122
1.15
0.14
2.3
2.0
20.09
2.91
mg/l
0.81
14
93
21
193
1.09
0.10
2.0
3.1
18.38
60.22
u/ml
1.60
21
187
5
46
1.09
0.09
1.0
1.1
—
25.78
—
0
9
10
89
1.13
0.07
1.3
1.4
—
—
—
0
0
10
92
1.09
0.03
1.5
1.7
—
—
—
0
0
20
207
0.96
0.01
2.8
1.9
—
—
—
0
0
19
186
1.02
0.00
2.3
1.7
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.7
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
5.15
—
0
8
0
7
0.00
-0.00
0.0
1.6
—
6.99
—
0
7
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint J10_PULMEOS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| J10_PULMEOS | 1.613 [1.36, 1.91] | < 0.001 |
| Birth year | 0.994 [0.99, 1.0] | 0.183 |
During the follow-up period (1.1.1998 — 31.12.2019), 276 out of 1053 females with J10_PULMEOS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| J10_PULMEOS | 1.865 [1.56, 2.23] | < 0.001 |
| Birth year | 0.986 [0.98, 1.0] | 0.004 |
During the follow-up period (1.1.1998 — 31.12.2019), 327 out of 857 males with J10_PULMEOS died.
Mortality risk
Mortality risk for people of age
years, who have J10_PULMEOS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.16% | 0.372% |
| 5 | 0.928% | 2.274% |
| 10 | 2.312% | 5.463% |
| 15 | 4.365% | 9.521% |
| 20 | 7.696% | 15.863% |
Relationships between endpoints
↥Index endpoint: J10_PULMEOS – Pulmonary eosinophilia, not elsewhere classified
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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