eosinophilic pneumonia: An inflammatory lung disorder characterized by an increased number of eosinophils in the lungs. The majority of cases are idiopathic, without identifiable cause. In a minority of cases, medications, fungal infections, and environmental triggers have been implicated. It manifests as acute or chronic. Acute eosinophilic pneumonia is a severe and rapidly progressing pneumonia that may lead to respiratory failure requiring mechanical ventilation. Chronic eosinophilic pneumonia follows a slower course and manifests as fever, dyspnea, cough, and weight loss.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
426 |
4. Check minimum number of eventsNone |
426 |
5. Include endpointsNone |
426 |
6. Filter based on genotype QC (FinnGen only) |
426 |
Control definitions (FinnGen only)
- Control exclude
- J10_INTERSTITIUM
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- J80-J84
- Name in latin
- Eosinophilia pulmonum non alibi classificata
Similar endpoints
↥List of similar endpoints to
Pulmonary eosinophilia, not elsewhere classified
based on the number of shared cases.
Similar with more cases:
- Respiratory diseases principally affecting the interstitium, IBD co-morbidites
- Other respiratory diseases principally affecting the interstitium
- Diagnoses used for exclusion with ILD
- Diseases of the respiratory system
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 3168 | 1780 | 1353 |
| Only index persons | 2462 | 1464 | 998 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.05 | 0.05 | 0.04 |
| Only index persons | 0.05 | 0.05 | 0.04 |
| Median age at first event (years) | |||
| Whole population | 59.21 | 58.03 | 60.60 |
| Only index persons | 56.56 | 55.95 | 57.46 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 426 | 241 | 185 |
| Unadjusted period prevalence (%) | 0.08 | 0.08 | 0.08 |
| Median age at first event (years) | 57.08 | 54.05 | 61.04 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 393
- Matched controls
- 3929
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
J82
ICD-10 Finland
Pulmonary eosinophilia, not elsewhere classified
+∞
323.0
344
*
H02AB06
ATC
prednisolone; systemic
14.1
96.5
348
1390
UGC12
NOMESCO Finland
Flexible bronchoscopy
13.3
72.8
138
153
J18.9
ICD-10 Finland
Pneumonia, unspecified
7.0
66.7
224
627
TGC00
NOMESCO Finland
Bronchial lavation
31.6
66.6
89
36
203
Kela drug reimbursment
Chronic asthma and similar chronic obstructive pulmonary diseases
6.5
58.4
193
505
J45.0
ICD-10 Finland
Predominantly allergic asthma
10.4
55.3
118
156
J45.9
ICD-10 Finland
Asthma, unspecified
6.3
53.0
176
450
GD1DD
NOMESCO Finland
High resolution CT examination of lungs
14.5
51.1
90
79
J45.1
ICD-10 Finland
Nonallergic asthma
10.0
50.8
110
147
R91
ICD-10 Finland
Abnormal findings on diagnostic imaging of lung
7.9
50.8
131
234
J84.9
ICD-10 Finland
Interstitial pulmonary disease, unspecified
+∞
47.9
45
*
5183A
ICD-9 Finland
Other diseases of lung, Pulmonary eosinophilia
+∞
40.3
38
*
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
4.2
39.1
231
998
NK6QA
NOMESCO Finland
Measurement of bone density from tow or more locations with X-ray
8.9
37.9
86
120
R03DC03
ATC
montelukast; oral
5.2
36.1
131
344
J84.8
ICD-10 Finland
Other specified interstitial pulmonary diseases
+∞
36.0
34
*
J15.9
ICD-10 Finland
Bacterial pneumonia, unspecified
6.4
34.7
101
202
J01MA14
ATC
moxifloxacin; systemic
6.5
34.5
98
190
R03AC02
ATC
salbutamol; inhalant
3.8
33.7
276
1498
R03BA02
ATC
budesonide; inhalant
4.3
30.3
133
414
D72.1
ICD-10 Finland
Eosinophilia
54.7
29.9
35
7
51920
ICD-8 Finland
Other diseases of respiratory system, Infiltratio pulmonis eosinophilica
+∞
29.5
28
*
R03AK06
ATC
salmeterol and fluticasone; inhalant
4.6
28.8
116
330
DM1QA
NOMESCO Finland
Paranasal sinuses X-ray examination in one projection
9.5
27.5
58
70
M05BA04
ATC
alendronic acid; oral
5.3
26.0
86
196
J84.1
ICD-10 Finland
Other interstitial pulmonary diseases with fibrosis
+∞
24.2
23
*
GD1AA
NOMESCO Finland
Thorax X-ray examination
3.0
24.2
236
1306
GD1ED
NOMESCO Finland
Extensive high resolution CT examination of lungs
11.4
22.7
43
42
DM1AA
NOMESCO Finland
Paranasal sinuses X-ray examination without contrast
9.7
22.3
46
53
R03BA01
ATC
beclometasone; inhalant
3.9
21.9
104
335
J01FA06
ATC
roxithromycin; oral
2.8
21.5
209
1120
R03BA05
ATC
fluticasone; inhalant
3.5
21.3
116
415
L04AX01
ATC
azathioprine; systemic
8.0
21.1
49
69
R03AK08
ATC
formoterol and beclometasone; inhalant
7.0
20.1
51
82
R03DA04
ATC
theophylline; systemic, rectal
5.6
19.9
61
125
R03BA08
ATC
ciclesonide; inhalant
4.9
19.8
69
164
R03AC13
ATC
formoterol; inhalant
5.8
19.8
58
113
J46
ICD-10 Finland
Status asthmaticus
9.2
19.5
41
49
TDM10
NOMESCO Finland
Puncture of maxillary antrum
7.9
19.4
45
63
H02AB04
ATC
methylprednisolone; systemic
3.5
19.4
105
372
J33.0
ICD-10 Finland
Polyp of nasal cavity
9.0
19.2
41
50
XG412
NOMESCO Finland
Flow-volume spirometry with bronchospasmolysis
6.2
19.0
53
97
J33.8
ICD-10 Finland
Other polyp of sinus
13.2
19.0
33
27
DMB20
NOMESCO Finland
Functional endoscopic opening of maxillary antrum
5.9
18.6
54
104
GCA98
NOMESCO Finland
Other bronchoscopic procedure on bronchus
46.4
18.4
22
5
H02AB07
ATC
prednisone; oral
3.4
17.9
98
349
J32.0
ICD-10 Finland
Chronic maxillary sinusitis
4.9
17.8
61
142
R03BB04
ATC
tiotropium bromide; inhalant
3.9
17.8
81
248
XG410
NOMESCO Finland
Flow-volume spirometry
6.8
17.6
45
73
J01MA12
ATC
levofloxacin; systemic
3.0
17.4
119
493
49300
ICD-8 Finland
Asthma, bronchiale
11.1
17.0
32
31
R03AC12
ATC
salmeterol; inhalant
6.1
16.6
46
83
A02BC02
ATC
pantoprazole; systemic
2.6
16.3
295
2102
J45.8
ICD-10 Finland
Mixed asthma
7.7
16.0
37
52
M30.1
ICD-10 Finland
Polyarteritis with lung involvement [Churg-Strauss]
+∞
15.7
15
*
R03AK07
ATC
formoterol and budesonide; inhalant
2.9
15.4
111
472
R01AD09
ATC
mometasone; nasal
2.3
14.7
201
1212
DM1AD
NOMESCO Finland
CT of paranasal sinuses and face area
7.6
14.6
34
48
R01AD08
ATC
fluticasone; nasal
2.5
14.3
137
685
R01AD05
ATC
budesonide; nasal
4.0
14.2
59
165
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
2.3
14.1
216
1365
J32.4
ICD-10 Finland
Chronic pansinusitis
14.3
13.9
23
17
GD1BD
NOMESCO Finland
Thorax extensive CT-examination
5.1
13.7
44
95
DNB20
NOMESCO Finland
Endoscopic ethmoidectomy
7.6
13.3
31
44
J47
ICD-10 Finland
Bronchiectasis
9.3
13.2
27
31
UDH02
NOMESCO Finland
Rhinopharyngoscopy
4.5
13.1
47
114
J01FA10
ATC
azithromycin; systemic
2.1
12.0
233
1590
M81.4
ICD-10 Finland
Drug-induced osteoporosis
23.7
11.7
16
7
DHB20
NOMESCO Finland
Polypectomy of internal nose
12.3
11.5
20
17
J01FA09
ATC
clarithromycin; systemic
2.2
11.3
142
793
GD1CD
NOMESCO Finland
Thorax extensive CT-examination
25.9
11.2
15
6
J01AA02
ATC
doxycycline; systemic
2.3
10.8
320
2562
XG474
NOMESCO Finland
Exhalation nntrogen oxide
6.9
10.4
25
38
R03AC03
ATC
terbutaline; inhalant
2.7
10.3
78
334
J01.0
ICD-10 Finland
Acute maxillary sinusitis
2.4
10.2
99
486
XG470
NOMESCO Finland
Measurement of diffusion capastity of the lungs
7.0
10.1
24
36
J31.0
ICD-10 Finland
Chronic rhinitis
3.6
10.0
45
135
R06.0
ICD-10 Finland
Dyspnoea
2.2
9.6
120
661
Z01.8
ICD-10 Finland
Other specified special examinations
2.3
9.6
105
543
J01FA15
ATC
telithromycin; oral
3.0
9.6
56
205
R03DC01
ATC
zafirlukast; oral
8.4
9.5
20
25
5BA08
NOMESCO Finland
NA
102.4
9.5
10
*
L04AA06
ATC
mycophenolic acid; systemic
9.9
9.4
18
19
R03AK11
ATC
formoterol and fluticasone; inhalant
6.4
9.1
23
38
TGD04
NOMESCO Finland
Needle biopsy of the lungs in bronchoscopy
24.7
9.0
12
5
GD1AD
NOMESCO Finland
Thorax CT examination
4.3
8.9
32
79
M05BB03
ATC
alendronic acid and colecalciferol; oral
6.4
8.7
22
36
R01AD01
ATC
beclometasone; nasal
2.4
8.7
77
358
J01DA06
ATC
[U] cefuroxime; systemic
2.5
8.7
69
303
M05BA07
ATC
risedronic acid; oral
4.6
8.6
29
67
DPA25
NOMESCO Finland
Trephine of frontal sinus through nose
20.6
8.5
12
6
R96
ICPC
Asthma
2.9
8.5
52
194
WW200
NOMESCO Finland
Immunization
6.3
8.3
21
35
R06AE07
ATC
cetirizine; oral
1.9
8.3
173
1153
R03BB01
ATC
ipratropium bromide; inhalant
4.1
8.3
31
80
DPA30
NOMESCO Finland
Sphenotomy
14.9
8.3
13
9
J20.9
ICD-10 Finland
Acute bronchitis, unspecified
2.3
8.0
85
429
J45
ICD-10 Finland
Asthma
2.7
7.8
55
224
ZX120
NOMESCO Finland
Intravenous
2.8
7.8
52
206
M80.4
ICD-10 Finland
Drug-induced osteoporosis with pathological fracture
45.9
7.7
9
*
4930A
ICD-9 Finland
Asthma, Extrinsic asthma[EXTRINSIC ASTHMA SINE EXACERBATIONE]
18.8
7.6
11
6
R01AD12
ATC
fluticasone furoate; nasal
2.0
7.6
113
659
R05
ICD-10 Finland
Cough
2.1
7.6
90
477
XQ800
NOMESCO Finland
Prick test
3.3
7.5
37
121
FB1BD
NOMESCO Finland
Extensive CT examination of arteria pulmonalis
2.9
7.4
46
174
J01CA04
ATC
amoxicillin; systemic
2.0
7.4
311
2584
R06AX27
ATC
desloratadine; oral
2.0
7.4
103
585
J84.0
ICD-10 Finland
Alveolar and parietoalveolar conditions
+∞
7.3
7
*
R03AL02
ATC
salbutamol and ipratropium bromide; inhalant
12.3
7.1
12
10
R01BA52
ATC
pseudoephedrine, combinations; oral
1.9
7.0
127
792
R81
ICPC
Pneumonia
4.2
7.0
25
62
J90
ICD-10 Finland
Pleural effusion, not elsewhere classified
3.9
7.0
27
72
A02BC01
ATC
omeprazole; systemic
1.9
7.0
127
795
4931B
ICD-9 Finland
Asthma, Intrinsic asthma[INTRINSIC ASTHMA CUM EXACERBATIONE]
40.8
6.8
8
*
GDA11
NOMESCO Finland
Thoracoscopic biopsy of lung
40.8
6.8
8
*
J02AC03
ATC
voriconazole; systemic
40.8
6.8
8
*
DMB00
NOMESCO Finland
Endonasal trephine of maxillary antrum
23.0
6.7
9
*
4930B
ICD-9 Finland
Asthma, Extrinsic asthma[EXTRINSIC ASTHMA CUM EXACERBATIONE]
23.0
6.7
9
*
1240
FHL
Bronchoscopy
6.1
6.7
17
29
ZXA10
NOMESCO Finland
Bilateral
2.0
6.6
89
496
J01MA02
ATC
ciprofloxacin; systemic
1.8
6.6
165
1141
A02BC05
ATC
esomeprazole; systemic
1.8
6.5
163
1130
R06.2
ICD-10 Finland
Wheezing
3.4
6.3
29
90
D86.9
ICD-10 Finland
Sarcoidosis, unspecified
18.4
6.3
9
5
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
2.4
6.2
54
249
P01BA02
ATC
hydroxychloroquine; oral
2.6
6.2
43
176
50301
ICD-8 Finland
Chronic sinusitis, Maxillaris NUD
8.8
6.1
12
14
4939X
ICD-9 Finland
Asthma, unspecified[ASTHMA BRONCHIALE NUD]
6.2
6.1
15
25
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
113
190
7.73
68.26
2.6
1.2
400.1
193.1
u/ml
1.39
106
171
73
103
8.35
50.80
2.8
2.8
—
—
—
0
0
37
19
21.23
48.11
1.9
1.1
5.3
0.1
u/ml
—
28
9
58
75
8.79
43.17
1.5
1.3
—
—
—
0
0
294
1581
3.77
36.57
12.4
5.3
59.0
57.3
%
1.80
287
1469
293
1602
3.66
34.85
13.2
5.5
24.5
27.6
%
5.72
288
1479
321
1946
3.64
30.56
14.9
8.8
5.0
4.0
e9/l
6.02
306
1701
27
23
12.47
26.74
2.1
1.6
—
—
—
0
0
37
53
7.55
24.99
1.9
1.6
—
—
—
0
0
32
43
7.97
22.79
1.9
1.6
—
—
—
0
0
35
54
6.97
22.08
2.2
1.7
—
—
—
0
0
18
11
17.04
21.23
1.6
1.2
—
—
—
0
0
40
76
5.70
20.55
2.2
1.6
—
—
—
0
0
39
73
5.78
20.35
2.3
1.6
—
—
—
0
0
28
39
7.61
19.30
4.2
3.9
—
—
—
0
0
231
1392
2.44
18.09
3.0
2.2
84.1
78.2
nmol/l
2.04
222
1219
27
41
6.96
17.23
1.9
1.7
—
—
—
0
0
25
35
7.53
17.13
1.9
1.7
—
—
—
0
0
20
22
9.49
16.55
1.2
1.0
—
—
—
0
0
82
311
3.03
16.32
2.3
2.0
316.8
370.4
nmol/l
0.49
76
277
22
28
8.23
16.30
2.4
1.7
—
—
—
0
0
28
48
6.17
15.92
1.9
1.6
—
—
—
0
0
22
32
7.19
14.55
2.4
1.6
—
—
—
0
0
40
103
4.18
14.31
1.5
1.8
—
—
—
0
0
25
47
5.59
12.92
1.8
1.7
—
—
—
0
0
333
2545
2.41
12.86
8.8
4.1
14.7
12.5
mm/h
2.16
325
2340
25
48
5.47
12.64
11.2
4.6
170.8
139.8
iu/ml
—
5
5
35
91
4.10
12.35
2.0
1.5
—
—
—
0
0
39
110
3.80
12.31
1.2
1.2
0.4
0.2
u/ml
—
6
10
23
42
5.73
12.25
1.1
1.2
—
—
—
0
0
252
1746
2.09
12.15
8.9
6.0
1.2
1.2
mmol/l
0.21
226
1476
29
66
4.64
12.10
1.0
1.1
—
—
—
0
0
114
584
2.30
12.04
2.5
1.8
—
—
—
0
0
26
55
4.97
11.81
6.5
3.8
57.0
58.8
%
0.21
26
55
232
1601
1.99
10.84
7.4
5.4
1.2
1.2
mmol/l
0.03
221
1442
87
414
2.38
10.78
2.2
1.7
—
—
—
0
0
337
2679
2.23
10.42
11.4
7.3
75.6
79.8
u/l
1.31
325
2493
16
24
6.89
10.25
1.0
1.1
—
—
—
0
0
11
10
11.27
10.20
2.8
7.3
—
—
—
0
0
86
418
2.32
10.12
2.3
1.8
—
—
—
0
0
60
248
2.65
9.98
1.7
1.6
—
—
—
0
0
15
9
17.21
9.94
3.6
1.3
39.7
87.8
ug/l
—
15
9
15
22
7.03
9.79
2.2
2.0
754.6
460.0
e6/l
—
8
7
257
1882
1.92
9.61
6.8
5.9
10.6
11.2
umol/l
0.71
249
1777
84
418
2.26
9.31
7.9
4.5
1.0
1.0
mmol/l
0.07
79
376
26
67
4.07
9.28
1.4
2.0
121.4
128.4
g/l
0.55
16
51
10
10
10.22
8.67
2.0
1.8
—
—
—
0
0
10
10
10.22
8.67
2.0
1.8
—
—
—
0
0
100
549
2.07
8.59
3.0
2.2
13.2
12.9
umol/l
0.13
92
500
31
96
3.40
8.52
1.6
1.6
1.3
0.0
iu/ml
—
8
15
11
13
8.66
8.50
1.6
1.8
—
—
—
0
0
10
11
9.29
8.11
2.1
1.7
—
—
—
0
0
16
31
5.32
7.99
2.1
1.6
—
—
—
0
0
16
31
5.32
7.99
2.1
1.6
—
—
—
0
0
16
31
5.32
7.99
2.1
1.6
—
—
—
0
0
123
750
1.90
7.74
2.0
1.7
1.0
1.1
mg/l
0.33
95
588
11
15
7.50
7.58
1.6
1.8
—
—
—
0
0
24
69
3.63
7.38
1.3
1.4
—
—
—
0
0
134
855
1.83
7.25
2.7
2.1
3.2
3.2
mg/l
0.02
119
728
16
34
4.85
7.22
1.2
1.1
0.2
2.0
u/ml
—
7
11
48
208
2.47
7.22
4.3
2.8
1.6
1.9
mmol/l
0.18
37
152
11
16
7.03
7.18
1.6
1.8
—
—
—
0
0
62
305
2.21
6.99
3.2
3.1
239.4
207.1
ng/l
0.19
56
280
88
500
1.96
6.75
3.0
2.2
2.3
2.3
g/l
0.48
81
458
263
2071
1.71
6.50
6.0
4.5
6.7
6.7
mmol/l
0.02
253
1943
84
476
1.95
6.48
3.2
2.2
23.1
22.4
%
0.18
74
404
143
960
1.74
6.37
4.0
3.0
0.3
0.5
e6/l
1.06
116
709
18
47
3.95
6.32
1.2
1.3
—
—
—
0
0
176
1253
1.69
6.31
4.8
3.1
—
—
—
0
0
53
255
2.23
6.30
3.6
3.2
91.1
79.3
ng/l
0.46
44
222
16
39
4.22
6.14
1.1
1.1
—
—
—
0
0
23
74
3.23
5.98
1.3
1.4
—
—
—
0
0
23
74
3.23
5.98
1.3
1.4
—
—
—
0
0
10
16
6.38
5.98
2.0
1.6
—
—
—
0
0
10
16
6.38
5.98
2.0
1.6
—
—
—
0
0
10
16
6.38
5.98
2.0
1.6
—
—
—
0
0
10
16
6.38
5.98
2.0
1.6
—
—
—
0
0
158
1106
1.68
5.97
3.9
3.2
27.5
31.9
u/l
2.63
151
1051
22
69
3.31
5.95
1.1
1.1
—
—
—
0
0
110
700
1.77
5.84
4.2
3.9
194.1
234.2
ng/l
0.16
95
570
11
20
5.62
5.83
1.6
1.7
—
—
—
0
0
92
565
1.80
5.48
1.4
1.3
18.7
36.5
iu/ml
2.12
27
185
184
1378
1.59
5.11
3.2
2.6
134.2
131.2
ug/l
0.06
169
1255
200
1529
1.58
5.08
7.3
4.2
33.8
35.3
g/l
3.28
189
1423
87
537
1.78
5.07
1.4
1.3
12.2
12.3
u/ml
0.00
29
209
8
7
11.61
4.80
3.1
1.4
—
—
—
0
0
233
1861
1.56
4.78
3.3
2.7
—
—
—
0
0
162
1207
1.55
4.46
4.6
3.2
2.3
2.4
mmol/l
0.24
148
1054
68
405
1.81
4.45
6.9
7.0
1.7
1.3
mmol/l
0.38
55
327
19
67
2.92
4.28
2.2
2.2
14.6
15.4
%
0.33
12
31
84
539
1.70
4.24
5.3
3.3
0.8
0.8
mmol/l
0.25
79
497
11
27
4.16
4.18
1.7
1.8
—
—
—
0
0
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
24
99
2.51
4.04
3.1
2.2
0.3
0.4
u/ml
0.86
17
58
11
28
4.01
4.00
1.0
1.0
—
—
—
0
0
12
33
3.71
3.95
1.2
1.1
—
—
—
0
0
11
29
3.87
3.82
1.8
1.2
—
—
—
0
0
11
29
3.87
3.82
1.8
1.2
—
—
—
0
0
21
84
2.58
3.77
2.1
2.0
8.7
7.8
kpa
1.03
21
74
10
26
3.91
3.54
1.1
1.1
—
—
—
0
0
10
26
3.91
3.54
1.1
1.1
—
—
—
0
0
10
27
3.77
3.37
1.1
1.1
—
—
—
0
0
10
27
3.77
3.37
1.1
1.1
—
—
—
0
0
10
27
3.77
3.37
1.1
1.1
—
—
—
0
0
147
1126
1.47
3.36
4.9
3.1
1669.0
1378.2
ng/l
0.42
136
960
19
77
2.54
3.34
1.2
1.2
—
—
—
0
0
53
321
1.74
3.28
6.1
3.0
3.1
2.2
mmol/l
0.50
43
257
22
98
2.31
3.18
2.0
2.2
23.9
24.9
mmol/l
0.47
22
81
13
44
3.02
3.16
1.2
1.3
—
—
—
0
0
29
146
2.06
3.13
2.5
1.7
—
—
—
0
0
5
5
10.10
2.98
1.2
1.0
—
—
—
0
0
25
122
2.11
2.93
2.7
2.2
138.5
321.8
ug/l
1.59
25
114
367
3385
1.61
2.91
29.0
14.5
22.5
24.0
mg/l
0.45
342
2690
7
13
5.45
2.88
1.0
1.2
—
—
—
0
0
79
548
1.54
2.88
3.5
2.9
0.8
2.3
e6/l
2.98
49
284
6
9
6.74
2.87
1.2
1.6
—
—
—
0
0
12
42
2.91
2.77
1.2
1.1
—
—
—
0
0
5
6
8.41
2.75
1.4
1.7
—
—
—
0
0
81
574
1.51
2.67
3.3
2.7
0.5
1.1
e6/l
2.20
51
307
138
1087
1.40
2.60
2.7
2.0
105.5
226.7
u/l
4.19
132
1026
139
1098
1.39
2.57
2.8
2.4
54.0
57.4
u/l
0.69
133
1013
117
897
1.42
2.57
4.1
2.5
12798.9
7735.5
umol/l
0.27
107
760
27
144
1.93
2.52
1.2
2.0
—
—
—
0
0
27
144
1.93
2.52
1.2
2.0
3.8
3.8
g/l
0.06
22
103
21
107
2.01
2.24
1.6
1.4
243.4
294.5
ug/g
—
10
61
5
9
5.61
2.22
1.0
1.1
—
—
—
0
0
11
42
2.66
2.20
1.5
1.7
30.9
33.1
pg
0.75
11
42
25
137
1.88
2.18
2.2
1.6
—
—
—
0
0
16
76
2.15
2.05
2.0
1.4
—
—
—
0
0
90
685
1.40
2.04
1.4
1.2
0.6
1.5
u/ml
1.66
17
182
19
98
1.98
1.98
1.4
1.2
—
—
—
0
0
8
27
3.00
1.94
2.1
2.9
13.8
13.2
%
—
8
27
56
396
1.48
1.88
2.4
2.7
5.8
8.7
umol/l
1.54
49
349
194
1681
1.28
1.77
4.7
3.8
0.0
0.0
estimate
0.00
46
322
6
18
3.37
1.75
1.0
1.8
—
—
—
0
0
6
18
3.37
1.75
1.0
1.8
—
—
—
0
0
5
13
3.88
1.72
1.0
1.2
—
—
—
0
0
194
1688
1.27
1.69
6.5
5.1
0.0
0.0
estimate
0.00
44
317
10
42
2.41
1.69
1.2
1.2
—
—
—
0
0
10
42
2.41
1.69
2.0
1.3
—
—
—
0
0
169
1447
1.28
1.68
5.2
3.8
29.4
60.9
ng/l
0.73
125
1056
16
83
1.96
1.66
2.6
2.3
1.7
1.6
mg/l
0.09
16
71
6
19
3.19
1.66
1.5
2.4
514.7
732.9
u/ml
—
6
19
34
223
1.57
1.63
1.9
1.6
—
—
—
0
0
106
857
1.32
1.62
1.5
1.6
21.6
21.5
nmol/l
0.03
94
714
195
1705
1.26
1.62
4.8
3.8
0.0
0.0
estimate
0.00
43
306
88
693
1.34
1.61
2.9
3.0
2.5
2.5
mmol/l
1.77
79
609
18
99
1.85
1.60
2.4
1.5
—
—
—
0
0
168
1447
1.27
1.57
2.2
2.0
97.3
94.9
pmol/l
0.30
84
721
7
28
2.52
1.45
1.0
1.3
—
—
—
0
0
29
428
0.65
1.41
15.6
7.6
—
—
—
0
0
280
2579
1.25
1.38
4.3
3.9
15.1
14.8
pmol/l
0.94
260
2306
31
210
1.51
1.32
1.5
1.4
—
—
—
0
0
109
911
1.26
1.28
1.9
1.7
1.3
1.3
mmol/l
0.14
94
763
15
85
1.79
1.24
1.5
1.3
—
—
—
0
0
18
108
1.70
1.24
1.4
1.1
—
—
—
0
0
316
2969
1.25
1.21
28.4
15.8
39.0
39.7
%
0.68
225
2043
43
317
1.40
1.21
2.8
2.3
24.8
35.0
u/l
1.63
36
262
6
26
2.33
1.19
7.8
3.7
—
—
—
0
0
321
3370
0.81
1.09
5.0
4.6
4.8
4.6
mmol/l
1.02
304
3094
329
3445
0.80
1.09
5.5
5.2
2.7
2.7
mmol/l
0.09
310
3139
57
451
1.30
1.04
1.5
1.4
—
—
—
0
0
5
22
2.29
1.03
2.6
1.3
—
—
—
0
0
236
2174
1.19
1.02
3.7
3.0
82.1
50.4
u/l
1.37
227
2007
327
3105
1.23
1.02
5.3
4.7
1.9
2.4
mu/l
0.64
303
2795
125
1089
1.21
1.00
4.9
3.9
4.3
7.7
mg/mmol
1.72
84
662
308
3236
0.83
0.98
4.3
4.1
1.2
1.3
mmol/l
0.77
284
2931
7
36
1.96
0.97
1.6
2.1
—
—
—
0
0
84
706
1.24
0.95
1.8
1.7
1114.1
1210.4
nmol/l
0.60
69
532
17
109
1.58
0.95
1.4
1.1
—
—
—
0
0
17
111
1.55
0.89
1.2
4.4
41.5
127.0
mg/l
0.80
11
86
15
95
1.60
0.88
1.4
1.3
—
—
—
0
0
36
276
1.33
0.84
3.3
2.7
60.6
62.1
ml/min/173m2
0.13
21
107
321
3344
0.84
0.82
4.9
4.5
1.6
1.5
mmol/l
6.64
301
3047
23
164
1.43
0.81
1.3
1.3
—
—
—
0
0
6
33
1.83
0.79
1.3
1.3
—
—
—
0
0
8
48
1.68
0.79
1.1
1.0
—
—
—
0
0
59
489
1.24
0.77
1.5
1.4
—
—
—
0
0
0
28
0.00
0.76
0.0
1.0
—
38.6
—
0
18
0
28
0.00
0.76
0.0
1.0
—
653.4
—
0
19
5
24
2.10
0.74
1.0
1.2
—
—
—
0
0
5
25
2.01
0.73
1.2
1.0
—
—
—
0
0
5
25
2.01
0.73
1.0
1.1
—
—
—
0
0
146
1324
1.16
0.71
5.0
4.0
—
—
—
0
0
10
61
1.65
0.69
4.3
2.8
105.3
105.8
mmol/l
—
10
61
16
111
1.46
0.67
1.3
4.4
26.2
31.8
mg/l
—
10
87
0
22
0.00
0.59
0.0
1.2
—
—
—
0
0
19
140
1.37
0.59
1.1
1.0
—
—
—
0
0
97
1075
0.87
0.54
4.7
5.0
1.7
2.6
ug/l
1.67
90
943
330
3198
1.14
0.52
21.3
13.9
76.3
77.4
ml/min/173m2
0.43
301
2633
15
109
1.39
0.51
1.3
4.3
—
2.5
—
0
12
330
3201
1.14
0.50
6.5
6.1
40.8
40.3
mmol/mol
0.40
312
2968
48
412
1.19
0.48
2.1
4.2
145.8
44.8
ug/l
0.31
43
347
102
929
1.13
0.47
5.1
4.1
0.0
0.0
estimate
0.50
43
314
18
231
0.77
0.46
2.2
1.8
—
—
—
0
0
39
335
1.18
0.40
1.8
1.8
1.4
1.5
%
0.20
32
290
0
19
0.00
0.39
0.0
1.6
—
—
—
0
0
11
80
1.38
0.38
1.7
1.4
—
—
—
0
0
9
67
1.35
0.38
1.0
1.2
141.7
5.2
e6/l
—
9
57
9
67
1.35
0.38
1.0
1.3
4485.7
1647.1
e6/l
—
9
59
12
89
1.36
0.38
1.6
1.3
—
—
—
0
0
22
179
1.24
0.38
3.5
2.3
1.2
1.1
%
0.15
22
179
9
68
1.33
0.38
3.3
1.8
—
—
—
0
0
10
72
1.40
0.37
3.0
1.5
3.2
6.4
iu/l
—
5
24
328
3352
0.91
0.34
4.8
4.8
5.8
6.0
mmol/l
2.32
307
3039
6
44
1.37
0.34
1.2
1.1
—
—
—
0
0
6
44
1.37
0.34
7.3
5.6
383.8
375.3
umol/l
—
6
37
82
758
1.10
0.30
5.4
4.0
1.0
1.0
kg/l
0.97
13
106
36
318
1.14
0.28
2.9
2.4
6.9
7.1
ug/l
0.04
30
278
11
85
1.30
0.28
2.9
1.8
—
—
—
0
0
55
602
0.90
0.27
2.9
3.0
0.7
0.8
ug/l
0.50
42
391
5
71
0.70
0.26
3.4
1.6
47.2
42.5
nmol/l
—
5
66
41
368
1.13
0.26
4.6
3.6
—
—
—
0
0
87
818
1.08
0.23
3.3
2.2
—
—
—
0
0
5
38
1.32
0.23
1.2
1.3
—
—
—
0
0
41
450
0.90
0.22
3.9
4.6
35.0
32.4
%
1.02
33
288
165
1591
1.06
0.21
4.9
3.9
—
—
—
0
0
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
0
11
0.00
0.21
0.0
1.2
—
—
—
0
0
0
10
0.00
0.21
0.0
1.3
—
—
—
0
0
0
10
0.00
0.21
0.0
1.7
—
1.3
—
0
10
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
0
13
0.00
0.21
0.0
1.3
—
—
—
0
0
0
14
0.00
0.20
0.0
1.0
—
—
—
0
0
6
80
0.75
0.15
1.0
1.3
41.8
25.9
iu/l
—
6
69
79
755
1.06
0.14
1.7
1.8
410.4
451.1
pmol/l
0.84
69
626
81
846
0.95
0.14
4.2
4.5
21.7
21.3
%
0.11
39
411
10
85
1.18
0.12
1.3
1.4
—
—
—
0
0
19
207
0.91
0.09
1.1
1.2
99.9
138.5
iu/ml
—
10
80
10
88
1.14
0.08
1.5
1.7
—
—
—
0
0
10
89
1.13
0.07
1.2
1.7
—
—
—
0
0
20
187
1.07
0.06
2.0
3.1
18.7
60.1
u/ml
1.51
20
181
18
174
1.04
0.00
2.2
1.7
—
—
—
0
0
19
194
0.98
0.00
2.7
1.9
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
0.00
0.0
1.1
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.7
—
—
—
0
0
12
120
1.00
0.00
2.3
2.0
23.3
2.9
mg/l
0.84
12
89
0
9
0.00
0.00
0.0
1.1
—
—
—
0
0
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
3.9
—
0
7
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint J10_PULMEOS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| J10_PULMEOS | 1.613 [1.36, 1.91] | < 0.001 |
| Birth year | 0.994 [0.99, 1.0] | 0.183 |
During the follow-up period (1.1.1998 — 31.12.2019), 276 out of 1053 females with J10_PULMEOS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| J10_PULMEOS | 1.865 [1.56, 2.23] | < 0.001 |
| Birth year | 0.986 [0.98, 1.0] | 0.004 |
During the follow-up period (1.1.1998 — 31.12.2019), 327 out of 857 males with J10_PULMEOS died.
Mortality risk
Mortality risk for people of age
years, who have J10_PULMEOS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.16% | 0.372% |
| 5 | 0.928% | 2.274% |
| 10 | 2.312% | 5.463% |
| 15 | 4.365% | 9.521% |
| 20 | 7.696% | 15.863% |
Relationships between endpoints
↥Index endpoint: J10_PULMEOS – Pulmonary eosinophilia, not elsewhere classified
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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