Deep bite that required surgery

K11_DEEP_BITE_SURGERY

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

  • OPER_BSSRO
1338

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 K07.23
  • Cause of death: ICD-10 K07.23

2 out of 7 registries used, show all original rules.

464

4. Check minimum number of events

None

464

5. Include endpoints

None

464

6. Filter based on genotype QC (FinnGen only)

464

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

First used in FinnGen datafreeze
DF7

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 2875 1851 1018
Only index persons 2854 1841 1013
Unadjusted period prevalence (%)
Whole population 0.04 0.05 0.03
Only index persons 0.06 0.07 0.04
Median age at first event (years)
Whole population 37.45 37.25 37.86
Only index persons 37.48 37.25 37.91

-FinnGen-

Key figures

All Female Male
Number of individuals 464 321 143
Unadjusted period prevalence (%) 0.10 0.11 0.06
Median age at first event (years) 39.58 38.87 41.16

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
408
Matched controls
4079
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
K07.13
ICD-10 Finland
Retrognaty, mandibular
1961.3
323.0
356
14
SJD00
NOMESCO Finland
Removal or reattacment of arrow in fixed orthodontisk device
434.5
323.0
322
35
EDC10
NOMESCO Finland
Sagittal osteotomy of ramus of mandible
+∞
323.0
408
6
SJD10
NOMESCO Finland
Attachment of arrow to fixed orthodontisk device
342.2
323.0
298
32
K07.23
ICD-10 Finland
Deep bite
+∞
323.0
408
33
SBB10
NOMESCO Finland
Teeth copy
142.2
320.9
341
140
SJD20
NOMESCO Finland
Attachment of modifiable arrow of fixed orthodontisk device
289.1
307.2
284
32
SJC10
NOMESCO Finland
Orthodontic bandage in one tooth
402.4
296.1
267
19
SBB00
NOMESCO Finland
Fotograf of mouth and teeth
145.1
281.4
284
63
SJC50
NOMESCO Finland
Removal of orthodontisk device with at least 7 brackets
221.7
272.7
260
32
SJB00
NOMESCO Finland
Fitting of loose orthodontic device with user information
200.3
252.5
244
30
SJD30
NOMESCO Finland
Demanding attachment of arrow to fixed orthodontisk device
276.2
225.5
213
16
EB1MA
NOMESCO Finland
Cephalometry with X-ray
110.5
217.9
228
46
SJX10
NOMESCO Finland
Short check-up visit for orthodontisk therapy
100.7
201.6
214
44
SJC03
NOMESCO Finland
Positioning and fixed attachment of brackets, extensive
160.9
195.3
195
23
SJD40
NOMESCO Finland
Fixation of ready made palatinal or lingual arrow
104.7
178.0
188
33
SJC01
NOMESCO Finland
Positioning and fixed attachment of single bracket (Bracket with fixed attachment)
129.0
176.1
181
25
SAA04
NOMESCO Finland
Special inverstigation of mouth
34.3
145.2
196
107
WZC10
NOMESCO Finland
Extensive specialist consultion with written report
37.6
140.8
184
87
SJC02
NOMESCO Finland
Positioning and fixed attachment of brackets
172.4
129.1
130
11
SJC40
NOMESCO Finland
Removal of orthodontisk device with at most 6 brackets
95.3
125.4
135
21
SXC05
NOMESCO Finland
Other oral or dental procedure
23.1
116.4
178
132
SJB60
NOMESCO Finland
External device grinding and adaptation
115.0
110.1
116
14
SJX11
NOMESCO Finland
Therapeutic intervention or check-up related to orthodontic treatment, restricted
64.4
110.0
126
28
K07.20
ICD-10 Finland
Crossbite (anterior)(posterior)
178.2
104.9
106
8
SJX20
NOMESCO Finland
Check-up visit for orthodontisk therapy
65.9
103.4
118
25
SJX21
NOMESCO Finland
Therapeutic intervention or check-up related to orthodontic treatment
82.1
98.9
109
18
SHB00
NOMESCO Finland
Prepation and fitting of bite rail to mouth
12.0
96.5
209
329
WZC05
NOMESCO Finland
Specialty-specific consultation based on referral by dentist or doctor
22.6
93.4
141
93
SJC00
NOMESCO Finland
Bracket with fixed attachment
220.2
87.0
87
5
SAC03
NOMESCO Finland
Separate planning of oral and dental treatment, very demanding
207.5
82.6
83
5
SXB00
NOMESCO Finland
Removeal of sutres from oral mucosa
14.8
69.7
124
117
K07.22
ICD-10 Finland
Anomalies of dental arch relationship
168.3
68.3
70
5
EBB10
NOMESCO Finland
Insertion of dental implant
51.9
67.2
80
19
SAA03
NOMESCO Finland
Extended examination of mouth
6.4
64.3
300
1236
K07.30
ICD-10 Finland
Spacing, abnormal of tooth or teeth
27.3
62.6
87
40
SHA02
NOMESCO Finland
Correction of physiology of bite - basic therapy visit
9.4
55.8
127
187
EEC05
NOMESCO Finland
Le Fort I osteotomy
317.3
55.7
55
*
SAC02
NOMESCO Finland
Separate planning of oral and dental treatment, demanding
55.0
55.2
65
14
WZC00
NOMESCO Finland
Planning of intervention or health care consultation
5.4
54.8
248
913
SJA04
NOMESCO Finland
Very demanding plan for orthodontic care
110.1
53.4
57
6
EFB40
NOMESCO Finland
Removal of internal or external fixation device from facial bones
158.4
53.3
55
*
SAC01
NOMESCO Finland
Separate planning of oral and dental treatment, standard
54.9
51.8
61
13
SJD50
NOMESCO Finland
Production and attachment of palatinal or lingual arrow
198.0
51.2
52
*
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
5.0
50.6
277
1209
SPC20
NOMESCO Finland
Attachment of crone of tooth to implant
101.3
49.1
53
6
K07.60
ICD-10 Finland
Snapping jaw
9.8
48.8
106
141
SHA03
NOMESCO Finland
Correction of physiology of bite - demanding therapy visit
15.8
47.6
80
62
SJF01
NOMESCO Finland
Assessment of need for orthodontic treatment
44.8
47.4
58
15
SJB10
NOMESCO Finland
Fitting of loose orthodontic device with user information, demanding
59.3
44.8
52
10
EBB15
NOMESCO Finland
Insertion of dental implant abutment
40.5
40.1
50
14
K07.04
ICD-10 Finland
Macrognathism (mandibular)(maxillary)
414.2
38.7
38
*
K07.24
ICD-10 Finland
Open bite
26.3
38.2
53
23
K07.10
ICD-10 Finland
Asymmetry of jaw
91.0
37.6
41
5
K07.27
ICD-10 Finland
Anomalies of dental arch relationship
54.6
37.4
44
9
K08.1
ICD-10 Finland
Loss of teeth due to accident, extraction or local periodontal disease
7.8
36.9
91
144
K07.14
ICD-10 Finland
Retrognaty, maxillary
107.5
36.4
39
*
SJA01
NOMESCO Finland
Estimation of need for orthodontic care
349.7
32.3
32
*
SJA03
NOMESCO Finland
Demanding plan for orthodontic care
63.5
30.6
35
6
SXC03
NOMESCO Finland
Other oral or dental procedure
27.6
29.4
40
16
SJX00
NOMESCO Finland
Reparation of orthodontiskt device by dentist
71.5
29.4
33
5
EBA10
NOMESCO Finland
Surgical removal of tooth
4.5
29.3
121
351
EB1AI
NOMESCO Finland
Cone beam imaging of teeth and jaws (one quarter)
16.3
27.2
44
30
K00.00
ICD-10 Finland
Hypodontia
20.4
26.2
39
21
SJA02
NOMESCO Finland
Plan for orthodontic care
144.1
25.9
27
*
EBB11
NOMESCO Finland
Insertion of additional dental implant in one session
41.7
25.3
31
8
SPA00
NOMESCO Finland
Changing form of teeth in prepation for prothetic work
11.1
23.5
45
45
K07.12
ICD-10 Finland
Prognathism (mandibular)(maxillary)
+∞
23.1
22
*
J01CE02
ATC
phenoxymethylpenicillin; oral
3.6
23.0
346
2489
SJE90
NOMESCO Finland
Finishing face of orthodontick therapy
66.3
22.1
25
*
K07.1
ICD-10 Finland
Anomalies of jaw-cranial base relationship
66.3
22.1
25
*
K07.18
ICD-10 Finland
Another anomaly in the relationship between jaw and skull base
121.5
21.8
23
*
EB1WA
NOMESCO Finland
NA
33.3
21.8
28
9
EB1BI
NOMESCO Finland
Cone beam imaging of teeth and jaws (1–2 quarters)
15.2
21.2
35
25
SPA20
NOMESCO Finland
Selection and insertion of implantdistans
63.5
21.1
24
*
SXC02
NOMESCO Finland
Other oral or dental procedure, restricted
8.2
19.5
44
59
AA3AI
NOMESCO Finland
Cone beam CT of facial bones
29.5
18.9
25
9
SHA04
NOMESCO Finland
Correction of physiology of bite - very demanding therapy visit
15.1
18.9
31
22
ECB40
NOMESCO Finland
Surgical treatment of fracture of alveolus
46.3
18.4
22
5
K01.0
ICD-10 Finland
Embedded teeth
10.0
18.0
36
39
EBA12
NOMESCO Finland
Complicated surgical removal of tooth
7.2
18.0
44
67
ZXA10
NOMESCO Finland
Bilateral
3.5
17.4
93
321
SPB10
NOMESCO Finland
Production of temporary crone to tooth
23.1
17.1
24
11
WX408
NOMESCO Finland
General anesthesy, balanced
2.7
16.5
139
649
SHA01
NOMESCO Finland
Correction of physiology of bite - simple therapy visit
3.3
16.1
89
315
SPC10
NOMESCO Finland
Attachment of standard crone of tooth
13.7
15.9
27
21
SAA02
NOMESCO Finland
Basic examination of mouth
2.6
15.4
319
2368
Z96.5
ICD-10 Finland
Presence of tooth-root and mandibular implants
29.9
15.3
20
7
SPA41
NOMESCO Finland
Precision impression for fixed dental prosthesis
14.1
14.4
24
18
OIKK
NOMESCO Finland
NA
11.5
14.2
26
24
SBB20
NOMESCO Finland
Tooth X-ray examination in conjunction with visit to dentist
18.4
14.0
21
12
K07.19
ICD-10 Finland
Anomalies in the relationship between jaw and skull base UNS
144.6
13.5
14
*
SDA02
NOMESCO Finland
Parodonthologic therapy
2.2
11.9
164
958
K07.11
ICD-10 Finland
Retrognathism (mandibular)(maxillary)
31.0
11.7
15
5
EDC30
NOMESCO Finland
Genioplasty
36.1
11.3
14
*
K07.25
ICD-10 Finland
Anomalies of dental arch relationship
10.0
10.9
21
22
SAA01
NOMESCO Finland
Simple examination of mouth
2.3
10.8
329
2638
WZC20
NOMESCO Finland
Multidisciplinary treatment meeting
4.4
10.6
38
93
SDE02
NOMESCO Finland
Periodontal treatment by dental hygienist
2.2
10.4
134
747
SPC40
NOMESCO Finland
Preparation of first or second intermediate attachment tooth for bridge
24.1
10.3
14
6
SPB20
NOMESCO Finland
Temporary bridge between two or more teeth
24.1
10.3
14
6
EB1JA
NOMESCO Finland
Double panorama tomography of teeth and jaws or similar X-ray examination
15.1
10.1
16
11
K01.17
ICD-10 Finland
Retained molar with obstruction in the lower jaw
5.6
9.9
28
53
TEW99
NOMESCO Finland
Other minor procedure in surgery of teeth, jaws, mouth and pharynx
4.4
9.8
35
85
SPA02
NOMESCO Finland
Preparation for dental prosthetics
9.0
9.4
19
22
R06.5
ICD-10 Finland
Mouth breathing
3.3
9.1
46
151
SDE03
NOMESCO Finland
Periodontal treatment by dental hygienist, extensive
2.1
9.1
130
750
SPC25
NOMESCO Finland
Other demanding attachment of crone of tooth
37.6
9.1
11
*
SPC08
NOMESCO Finland
Implant crown
24.6
9.0
12
5
EG1CG
NOMESCO Finland
Extensive MRI examination of mandipular joint with high intensity magnet
20.5
8.5
12
6
ECU00
NOMESCO Finland
Removal of implant or external fixation device from alveoli
+∞
8.4
8
*
N02BE01
ATC
paracetamol; systemic, rectal
2.1
8.2
342
2885
EB1AD
NOMESCO Finland
Cone beam CT of teeth and jaws (one quarter)
17.6
8.1
12
7
EBA00
NOMESCO Finland
Extraction of tooth
1.9
7.9
144
906
WZB00
NOMESCO Finland
Telephone receipt or other advice
1.9
7.8
143
902
ECB05
NOMESCO Finland
Mucogingival repair
45.9
7.7
9
*
SPC09
NOMESCO Finland
Implant crown, demanding
45.9
7.7
9
*
SPAT1324
SPAT
Screening procedure
2.0
7.7
112
646
K07.9
ICD-10 Finland
Dentofacial anomaly, unspecified
81.5
7.4
8
*
SDA03
NOMESCO Finland
Demanding parodonthologic therapy
1.8
7.2
172
1178
EB1CI
NOMESCO Finland
Cone beam imaging of teeth and jaws (3-4 quarters)
8.1
7.2
15
19
M01AE01
ATC
ibuprofen; systemic, rectal
2.7
6.8
384
3484
G50.8
ICD-10 Finland
Other disorders of trigeminal nerve
40.7
6.8
8
*
K07.26
ICD-10 Finland
Anomalies of dental arch relationship
40.7
6.8
8
*
EAB10
NOMESCO Finland
Excision and repair of frenum of lip
40.7
6.8
8
*
EMAK
NOMESCO Finland
NA
3.8
6.7
27
75
EDW99
NOMESCO Finland
Other operation on mandible
22.9
6.7
9
*
K07.65
ICD-10 Finland
Temporomandibular joint-pain-dysfunction syndrome
10.3
6.6
12
12
ECA30
NOMESCO Finland
Excision of lesion of gingiva
10.3
6.6
12
12
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
1.7
6.5
189
1363
TEG00
NOMESCO Finland
Punction of mandibular joint
70.9
6.4
7
*
K07.33
ICD-10 Finland
Crowding of tooth or teeth
18.4
6.3
9
5
K07.05
ICD-10 Finland
Micrognatia (hypoplasia) of both jaws
+∞
6.3
6
*
K07.29
ICD-10 Finland
Anomaly in the relationship between the tooth arches UNS
+∞
6.3
6
*
QA1S1
NOMESCO Finland
Photography of skin or subcutaneous tissue in head
27.1
6.2
8
*
EB1BD
NOMESCO Finland
Extensive cone beam CT of teeth and jaws (two quarters)
27.1
6.2
8
*
K06.00
ICD-10 Finland
Local gingivore traction
6.2
6.0
15
25

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
235
1738
1.71
7.45
3.4
4.0
—
—
—
0
0
324
2751
1.59
4.91
3.5
3.6
7.0
9.1
mm/h
5.80
311
2602
133
964
1.53
3.99
3.3
3.1
0.0
0.0
estimate
1.08
41
359
115
824
1.53
3.60
3.4
3.0
1.0
1.0
kg/l
0.14
18
102
443
4201
2.20
3.26
9.9
9.8
—
—
—
0
0
44
253
1.82
3.22
3.1
3.0
—
—
—
0
0
19
83
2.34
2.88
1.0
1.1
9.0
5.4
u/ml
—
7
42
47
286
1.72
2.86
1.2
1.3
143.6
278.7
u/ml
0.72
47
264
41
240
1.78
2.85
1.3
1.4
—
—
—
0
0
220
1850
1.36
2.72
4.0
4.1
0.0
0.0
estimate
0.50
40
362
41
244
1.75
2.70
1.7
1.5
352.9
285.9
mu/l
0.38
36
218
219
1844
1.36
2.67
3.0
2.9
0.0
0.0
estimate
0.00
40
357
82
582
1.50
2.65
1.4
1.6
73684647.3
42395858.4
pmol/l
0.16
76
526
410
3846
1.57
2.51
7.9
11.0
3.9
3.9
mmol/l
0.21
403
3736
9
26
3.51
2.49
2.0
1.3
—
—
—
0
0
407
3829
1.51
2.26
7.9
11.0
139.9
139.7
mmol/l
1.58
399
3733
138
1110
1.35
2.19
2.3
2.7
14.0
20.5
ng/l
1.02
65
553
217
1868
1.30
2.12
3.0
2.9
0.0
0.0
estimate
0.00
38
347
135
1093
1.33
2.04
2.3
2.5
—
—
—
0
0
15
70
2.18
2.00
1.3
1.1
—
—
—
0
0
18
91
2.02
1.98
1.1
1.1
0.5
1.9
u/ml
—
6
35
15
71
2.15
1.94
1.0
1.1
11.9
3.2
u/ml
—
8
22
17
87
1.99
1.82
1.8
1.5
—
—
—
0
0
32
490
0.63
1.79
2.0
3.4
0.9
0.8
mmol/l
2.34
27
464
412
3920
1.46
1.79
8.6
10.7
17.1
20.0
mg/l
0.81
318
2980
14
67
2.12
1.77
1.3
3.9
19.9
18.5
mg/l
—
8
45
13
61
2.16
1.73
1.0
1.1
2.6
4.8
u/ml
—
7
20
18
98
1.87
1.64
1.3
1.4
21.6
24.4
u/l
—
10
83
13
63
2.09
1.61
1.2
1.4
—
—
—
0
0
82
638
1.35
1.61
1.5
1.4
—
—
—
0
0
380
3585
1.33
1.59
4.5
4.6
1.8
2.1
mu/l
0.48
367
3420
74
946
0.74
1.58
1.7
1.7
1.5
1.4
mmol/l
0.21
67
841
13
245
0.52
1.57
1.1
1.1
—
—
—
0
0
32
209
1.57
1.56
1.3
1.4
237.9
255.0
miu/ml
0.10
15
110
71
910
0.74
1.54
3.7
6.4
—
—
—
0
0
23
139
1.69
1.51
1.9
1.7
—
—
—
0
0
13
65
2.03
1.50
3.0
3.0
—
—
—
0
0
70
895
0.74
1.49
2.6
3.6
7.4
7.4
ph
0.18
12
161
6
22
2.75
1.44
1.0
1.1
1386.0
1807.7
miu/ml
—
6
22
56
730
0.74
1.36
3.1
4.1
—
—
—
0
0
39
275
1.46
1.36
1.8
1.9
—
—
—
0
0
117
979
1.26
1.34
3.1
4.5
—
—
—
0
0
39
276
1.45
1.34
1.8
1.9
—
—
—
0
0
100
1198
0.79
1.30
4.6
5.8
—
—
—
0
0
5
18
2.80
1.29
1.0
1.2
—
—
—
0
0
384
3658
1.29
1.27
3.4
3.6
5.6
5.7
mmol/l
3.64
369
3448
14
77
1.84
1.26
1.0
1.1
0.9
2.8
u/ml
—
7
16
269
2468
1.21
1.26
2.7
2.9
—
—
—
0
0
38
271
1.44
1.26
2.6
2.2
8473.5
3305.6
u/l
0.41
19
119
38
274
1.42
1.20
1.8
2.0
—
—
—
0
0
54
414
1.34
1.19
1.4
1.6
—
—
—
0
0
38
275
1.42
1.18
1.8
1.8
—
—
—
0
0
102
855
1.25
1.15
1.6
1.7
0.7
0.8
mg/l
0.24
69
641
96
1136
0.80
1.11
1.6
1.8
103.4
97.2
pmol/l
0.67
50
598
27
383
0.69
1.10
1.4
2.3
23.4
24.8
%
0.17
22
334
13
216
0.59
1.07
6.8
9.4
—
—
—
0
0
209
1896
1.19
1.05
3.3
4.6
6.0
6.4
mmol/l
3.04
189
1734
292
2729
1.19
1.02
5.2
7.1
70.6
75.0
u/l
1.94
280
2596
36
266
1.38
1.01
1.2
1.2
—
—
—
0
0
83
692
1.24
0.99
3.7
3.2
1.5
1.5
ug/l
0.14
77
642
387
3719
1.24
0.98
3.4
3.4
1.3
1.3
mmol/l
0.20
373
3542
47
365
1.32
0.97
1.3
1.7
—
—
—
0
0
53
419
1.30
0.97
2.8
2.3
0.6
0.6
ug/l
0.16
20
216
0
31
0.00
0.96
0.0
1.2
—
—
—
0
0
24
166
1.47
0.96
1.0
1.3
11.1
10.4
u/l
0.08
19
134
324
3066
1.19
0.94
4.3
4.1
14.4
14.4
pmol/l
0.11
312
2891
43
332
1.33
0.93
1.2
1.3
30.7
27.4
iu/l
0.23
38
286
34
253
1.37
0.93
1.9
2.0
—
—
—
0
0
43
548
0.76
0.92
2.3
3.4
351.5
503.3
ng/l
0.16
22
347
22
311
0.69
0.90
2.4
3.0
—
—
—
0
0
71
589
1.24
0.89
1.6
1.6
—
—
—
0
0
125
1098
1.19
0.89
1.8
2.1
—
—
—
0
0
18
259
0.68
0.82
1.3
1.4
—
—
—
0
0
16
106
1.53
0.80
1.8
1.9
206.4
222.8
pmol/l
0.23
16
100
32
244
1.33
0.78
1.2
1.2
—
—
—
0
0
0
27
0.00
0.77
0.0
1.7
—
—
—
0
0
6
34
1.77
0.76
1.0
1.0
—
—
—
0
0
11
67
1.66
0.75
1.4
1.4
—
—
—
0
0
122
1085
1.17
0.75
2.1
2.6
54.2
54.5
u/l
0.03
113
1024
9
54
1.68
0.75
1.0
2.7
4.9
5.1
kpa
—
9
54
9
54
1.68
0.75
1.0
2.7
9.4
9.3
kpa
—
9
54
5
24
2.09
0.74
1.0
1.3
5.0
7.2
ug/l
—
5
18
7
38
1.85
0.74
1.4
1.5
—
—
—
0
0
77
660
1.20
0.73
1.5
1.3
—
—
—
0
0
68
578
1.21
0.70
2.2
2.4
65.7
109.6
ug/g
1.62
56
463
37
461
0.79
0.69
1.3
1.2
—
—
—
0
0
7
117
0.59
0.68
1.4
1.2
—
69.2
—
0
13
28
214
1.33
0.68
2.1
2.0
—
—
—
0
0
17
119
1.44
0.68
2.5
2.7
—
—
—
0
0
211
1965
1.14
0.67
4.4
6.4
0.2
0.2
e9/l
0.10
200
1776
185
1710
1.14
0.66
2.3
2.3
—
—
—
0
0
75
861
0.85
0.64
1.9
2.5
0.1
0.4
e6/l
2.33
59
636
6
103
0.58
0.62
3.8
3.3
1.1
1.4
mg/l
—
6
96
5
30
1.67
0.61
1.4
1.2
—
—
—
0
0
135
1229
1.14
0.61
1.5
1.6
—
—
—
0
0
199
1857
1.13
0.60
2.6
2.7
70.9
98.8
ug/l
2.99
192
1763
0
21
0.00
0.60
0.0
1.1
—
—
—
0
0
0
22
0.00
0.59
0.0
1.1
—
—
—
0
0
0
23
0.00
0.58
0.0
1.6
—
—
—
0
0
13
183
0.70
0.56
1.8
1.4
—
—
—
0
0
209
1963
1.12
0.56
4.5
5.8
1.9
2.0
e9/l
0.76
198
1776
165
1529
1.12
0.56
1.8
1.9
—
—
—
0
0
27
214
1.28
0.53
2.7
2.0
—
—
—
0
0
120
1310
0.89
0.52
3.5
5.9
1.2
1.2
mmol/l
0.08
112
1218
18
136
1.34
0.50
1.3
1.2
—
—
—
0
0
7
46
1.53
0.48
1.1
1.1
—
—
—
0
0
13
177
0.73
0.48
1.7
1.3
—
—
—
0
0
48
412
1.18
0.48
1.5
1.6
1132.8
1188.7
nmol/l
0.22
40
331
20
155
1.30
0.47
2.3
7.9
—
—
—
0
0
79
878
0.88
0.46
1.5
1.3
2.3
2.2
g/l
0.17
63
579
263
2521
1.10
0.45
3.3
3.6
—
—
—
0
0
398
3899
1.15
0.44
3.9
4.0
3.0
2.9
mmol/l
2.02
381
3708
5
31
1.62
0.43
2.0
1.7
1.0
1.0
g/l
—
5
31
5
32
1.57
0.42
1.4
2.1
105.4
105.4
mmol/l
—
5
32
5
32
1.57
0.42
1.4
2.1
3.9
4.0
mmol/l
—
5
32
5
32
1.57
0.42
1.4
2.1
—
—
—
0
0
0
15
0.00
0.41
0.0
1.7
—
16.1
—
0
15
0
16
0.00
0.41
0.0
1.3
—
2925.1
—
0
8
0
17
0.00
0.40
0.0
4.1
—
7.4
—
0
17
394
3863
1.13
0.40
3.7
3.7
5.0
4.8
mmol/l
2.00
379
3693
54
476
1.15
0.40
1.1
1.2
—
—
—
0
0
0
18
0.00
0.40
0.0
3.6
—
—
—
0
0
0
19
0.00
0.39
0.0
1.1
—
—
—
0
0
0
19
0.00
0.39
0.0
1.2
—
12.9
—
0
19
9
67
1.35
0.38
1.1
2.5
7.4
7.4
ph
—
9
54
12
89
1.36
0.38
1.1
1.3
2.3
5.8
e6/l
0.52
12
69
12
89
1.36
0.38
1.2
1.4
239.9
150.5
e6/l
0.19
12
72
8
112
0.71
0.37
1.1
1.2
—
3.1
—
0
14
90
826
1.11
0.37
3.6
2.9
—
—
—
0
0
80
730
1.12
0.36
1.3
1.3
27.4
26.5
iu/ml
0.02
27
248
80
874
0.90
0.36
2.0
2.4
—
—
—
0
0
12
90
1.34
0.36
1.1
1.3
3.7
3.7
mmol/l
0.07
12
82
14
178
0.78
0.35
1.6
1.3
—
—
—
0
0
41
360
1.15
0.33
1.9
2.1
388.8
374.7
nmol/l
0.12
36
339
6
90
0.66
0.33
2.2
2.3
160.8
315.3
ug/l
—
6
83
101
940
1.10
0.32
1.7
2.1
130.9
228.8
u/l
0.80
96
892
392
3855
1.11
0.32
3.7
3.7
1.5
1.5
mmol/l
0.75
377
3674
96
892
1.10
0.32
1.8
1.7
—
—
—
0
0
16
197
0.81
0.31
1.6
2.2
71.8
68.2
g/l
2.68
16
185
93
864
1.10
0.31
1.5
2.2
311.5
4640.7
umol/l
2.45
86
787
7
55
1.28
0.30
1.0
2.4
—
—
—
0
0
32
280
1.15
0.28
3.4
10.7
0.4
1.2
mmol/l
0.49
11
221
86
801
1.09
0.27
2.2
2.8
—
—
—
0
0
197
1896
1.07
0.27
4.5
5.9
0.0
0.0
e9/l
0.03
188
1686
37
414
0.88
0.26
1.4
1.3
—
—
—
0
0
89
950
0.92
0.26
1.9
2.6
18.6
64.9
e6/l
1.73
70
719
76
706
1.09
0.26
1.2
1.2
15.9
7.7
u/ml
0.45
43
294
5
75
0.66
0.26
1.0
1.1
—
—
—
0
0
196
1889
1.07
0.26
4.5
5.8
0.5
0.5
e9/l
0.32
188
1682
161
1678
0.94
0.25
6.8
7.8
0.0
0.0
e9/l
1.16
151
1387
36
401
0.89
0.24
1.5
1.4
—
—
—
0
0
48
438
1.11
0.24
1.3
1.4
—
—
—
0
0
55
597
0.91
0.23
2.1
2.2
534.4
556.0
mosm/kgh2o
0.28
42
518
0
10
0.00
0.21
0.0
3.4
—
260.6
—
0
10
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
2.2
—
—
—
0
0
39
428
0.90
0.21
1.5
1.4
—
—
—
0
0
0
13
0.00
0.21
0.0
1.3
—
—
—
0
0
0
13
0.00
0.21
0.0
1.2
—
—
—
0
0
0
13
0.00
0.21
0.0
1.6
—
—
—
0
0
0
13
0.00
0.21
0.0
1.2
—
—
—
0
0
0
14
0.00
0.20
0.0
1.0
—
—
—
0
0
9
113
0.79
0.20
1.3
1.1
—
—
—
0
0
9
113
0.79
0.20
1.3
1.1
—
—
—
0
0
13
154
0.84
0.19
1.2
1.7
—
—
—
0
0
33
363
0.90
0.19
1.1
1.2
—
—
—
0
0
41
377
1.10
0.18
1.1
1.3
57.3
162.1
iu/ml
3.73
17
158
13
153
0.85
0.18
1.2
1.5
—
10.1
—
0
5
113
1178
0.95
0.18
2.2
3.0
26.0
85.7
e6/l
1.24
78
785
10
82
1.22
0.17
1.0
1.2
—
—
—
0
0
15
173
0.86
0.17
1.7
3.2
5.2
5.1
kpa
0.07
15
165
343
3384
1.05
0.16
3.9
4.4
37.0
38.2
mmol/mol
2.05
329
3230
15
172
0.87
0.16
1.7
3.2
—
7.4
—
0
19
73
768
0.94
0.16
1.9
2.0
2.8
2.8
mg/l
0.03
65
669
6
79
0.76
0.15
3.7
1.8
—
—
—
0
0
12
140
0.85
0.15
1.1
1.1
—
—
—
0
0
21
188
1.12
0.15
2.0
3.0
—
—
—
0
0
136
1317
1.05
0.15
2.9
4.8
38.1
37.0
g/l
1.95
130
1247
166
1705
0.96
0.14
4.3
5.9
0.7
0.7
%
0.00
161
1610
7
88
0.79
0.14
3.1
2.5
—
—
—
0
0
7
89
0.78
0.14
1.3
1.2
—
—
—
0
0
72
754
0.95
0.14
2.5
3.4
903.0
337.3
mg/l
0.28
51
499
9
107
0.84
0.13
1.1
1.2
—
—
—
0
0
11
127
0.86
0.12
1.0
1.1
—
—
—
0
0
19
172
1.11
0.11
1.3
1.2
—
—
—
0
0
14
125
1.12
0.10
3.1
7.4
—
—
—
0
0
17
154
1.11
0.10
1.4
1.6
—
—
—
0
0
54
517
1.05
0.09
1.9
1.8
—
—
—
0
0
186
1828
1.03
0.09
4.1
5.6
54.5
56.5
%
1.95
179
1738
39
370
1.06
0.09
1.7
1.5
—
—
—
0
0
22
237
0.92
0.09
3.3
3.2
2.2
1.9
mmol/l
0.17
16
189
5
63
0.79
0.08
2.6
2.7
23.7
24.0
mmol/l
—
5
58
11
123
0.89
0.08
2.1
3.2
23.8
23.9
mmol/l
—
6
113
77
793
0.97
0.08
3.0
4.0
6.3
11.5
mg/mmol
0.48
55
519
221
2182
1.02
0.07
5.8
8.9
3.7
3.9
e9/l
1.45
205
1929
6
74
0.81
0.07
1.0
1.1
—
—
—
0
0
15
137
1.10
0.07
2.0
2.0
—
—
—
0
0
8
78
1.03
0.07
1.1
1.4
—
—
—
0
0
187
1844
1.02
0.07
4.3
5.8
30.8
29.4
%
1.17
182
1750
9
86
1.05
0.07
1.4
1.7
—
—
—
0
0
43
447
0.96
0.06
1.7
2.2
—
—
—
0
0
23
244
0.94
0.06
3.2
3.4
—
—
—
0
0
13
142
0.91
0.06
3.2
15.3
—
—
—
0
0
9
101
0.89
0.06
1.0
1.1
—
—
—
0
0
107
1091
0.97
0.06
5.1
5.5
1.1
1.1
inr
0.09
35
352
12
109
1.10
0.06
1.5
1.2
—
—
—
0
0
67
688
0.97
0.06
1.8
1.7
—
—
—
0
0
347
3450
1.02
0.05
10.0
12.9
13.4
13.5
%
0.34
341
3402
102
1002
1.02
0.05
1.4
1.3
0.8
1.6
u/ml
1.10
40
293
150
1482
1.02
0.04
3.7
6.6
1.2
1.2
mmol/l
0.13
131
1265
14
150
0.93
0.04
3.5
8.3
22.9
25.0
mmol/l
2.44
14
150
88
868
1.02
0.03
2.2
2.1
—
—
—
0
0
66
649
1.02
0.02
1.8
2.2
4.2
7.7
e6/l
1.54
58
578
176
1773
0.99
0.02
4.4
6.1
8.4
8.2
%
0.55
171
1687
27
261
1.04
0.02
10.7
12.2
1.0
1.2
inr
—
6
42
176
1770
0.99
0.01
4.1
6.1
9.7
10.4
umol/l
0.71
169
1695
111
1119
0.99
0.01
2.1
2.0
—
—
—
0
0
23
224
1.03
0.00
1.0
1.1
—
—
—
0
0
12
125
0.96
0.00
1.8
3.4
—
—
—
0
0
14
135
1.04
0.00
3.2
2.2
—
—
—
0
0
25
255
0.98
0.00
1.9
4.1
—
—
—
0
0
26
265
0.98
0.00
1.4
1.3
—
21.9
—
0
11
13
127
1.02
0.00
3.4
2.2
1.4
1.3
%
0.08
13
127
17
173
0.98
0.00
1.1
1.3
—
—
—
0
0
13
128
1.02
0.00
3.8
3.1
26.0
25.2
mmol/l
0.39
13
122
10
99
1.01
0.00
5.6
4.3
—
—
—
0
0
58
585
0.99
0.00
1.2
1.4
448.0
551.9
titre
—
10
119
387
3874
0.99
0.00
8.8
11.2
40.2
40.7
%
0.50
309
3227
0
7
0.00
0.00
0.0
1.0
—
7.1
—
0
7
0
7
0.00
0.00
0.0
10.1
—
—
—
0
0
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
5
58
0.86
0.00
2.8
2.6
—
—
—
0
0
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
0.00
0.0
1.6
—
—
—
0
0
0
6
0.00
0.00
0.0
11.7
—
—
—
0
0
0
9
0.00
0.00
0.0
1.1
—
—
—
0
0
0
6
0.00
0.00
0.0
2.2
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
5
54
0.93
0.00
1.6
3.1
—
—
—
0
0
0
8
0.00
0.00
0.0
1.4
—
1.7
—
0
8
8
87
0.92
0.00
1.5
1.2
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
0.00
0.0
1.2
—
—
—
0
0
5
51
0.98
0.00
1.4
1.3
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
6.6
—
—
—
0
0
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
6
65
0.92
0.00
1.3
1.1
—
—
—
0
0
0
6
0.00
0.00
0.0
2.0
—
—
—
0
0
5
53
0.94
0.00
1.0
1.2
10.8
11.0
u/l
—
5
46
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
6
67
0.89
0.00
1.0
1.6
—
—
—
0
0
0
8
0.00
0.00
0.0
3.9
—
—
—
0
0
0
6
0.00
0.00
0.0
2.2
—
—
—
0
0
0
6
0.00
0.00
0.0
1.7
—
—
—
0
0
0
8
0.00
0.00
0.0
8.4
—
25.0
—
0
8
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.8
—
—
—
0
0
7
75
0.93
0.00
1.1
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
5.6
—
—
—
0
0
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
0.00
0.0
2.6
—
—
—
0
0
0
6
0.00
0.00
0.0
1.7
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
15.1
—
0
5
9
97
0.93
0.00
1.1
1.5
—
—
—
0
0
0
8
0.00
0.00
0.0
1.3
—
129.1
—
0
8

Mortality – FinRegistry

Association

Association between endpoint K11_DEEP_BITE_SURGERY and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have K11_DEEP_BITE_SURGERY.

N-year risk Females Males
1 No data No data
5 No data No data
10 No data No data
15 No data No data
20 No data No data

Relationships between endpoints

Index endpoint: K11_DEEP_BITE_SURGERY – Deep bite that required surgery

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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