muscular disease: Acquired, familial, and congenital disorders of skeletal muscle and smooth muscle.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
226 |
4. Check minimum number of eventsNone |
226 |
5. Include endpointsNone |
226 |
6. Filter based on genotype QC (FinnGen only) |
226 |
Control definitions (FinnGen only)
- Control exclude
- M13_SOFTTISSUE
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- M62
- Name in latin
- Ruptura musculi non traumatica
Similar endpoints
↥List of similar endpoints to
Other rupture of muscle
based on the number of shared cases.
Similar with more cases:
- Disorders of muscles
- Soft tissue disorders
- Diseases of the musculoskeletal system and connective tissue
- Any operation in hilmo
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1604 | 713 | 883 |
| Only index persons | 1502 | 672 | 830 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.02 | 0.02 | 0.02 |
| Only index persons | 0.03 | 0.02 | 0.03 |
| Median age at first event (years) | |||
| Whole population | 53.09 | 53.57 | 52.63 |
| Only index persons | 52.22 | 52.43 | 52.04 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 226 | 114 | 112 |
| Unadjusted period prevalence (%) | 0.04 | 0.04 | 0.05 |
| Median age at first event (years) | 53.87 | 51.14 | 56.65 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 198
- Matched controls
- 1981
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
M62.1
ICD-10 Finland
Other rupture of muscle (nontraumatic)
+∞
286.6
198
*
M79.6
ICD-10 Finland
Pain in limb
4.3
17.8
80
267
M75.1
ICD-10 Finland
Rotator cuff syndrome
5.3
16.0
53
127
QBJ30
NOMESCO Finland
Correction of abdominal apron
53.8
13.0
15
*
N02BE01
ATC
paracetamol; systemic, rectal
3.5
9.3
175
1355
M79.1
ICD-10 Finland
Myalgia
4.5
9.2
33
84
X58
ICD-10 Finland
Exposure to other specified factors
4.0
9.1
38
112
S46.0
ICD-10 Finland
Injury of muscle(s) and tendon(s) of the rotator cuff of shoulder
6.2
8.8
23
41
N02AJ06
ATC
codeine and paracetamol; systemic
2.6
8.7
83
430
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
2.7
8.5
73
357
K42.9
ICD-10 Finland
Umbilical hernia without obstruction or gangrene
6.2
8.4
22
39
N03AX16
ATC
pregabalin; oral
3.1
8.3
50
195
NBG15
NOMESCO Finland
Acromioplastia, arthroscopic
18.1
8.2
12
7
M76.6
ICD-10 Finland
Achilles tendinitis
10.0
7.9
15
16
N03AX12
ATC
gabapentin; oral
3.8
7.8
33
98
M75.4
ICD-10 Finland
Impingement syndrome of shoulder
10.7
7.7
14
14
K43.9
ICD-10 Finland
Other and unspecified ventral hernia without obstruction or gangrene
6.5
7.6
19
32
M79.0
ICD-10 Finland
Rheumatism, unspecified
83.1
7.5
8
*
M79.2
ICD-10 Finland
Neuralgia and neuritis, unspecified
83.1
7.5
8
*
N02AX02
ATC
tramadol; systemic, rectal
2.4
7.4
86
483
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
2.3
7.2
94
560
S18
ICPC
Laceration/cut
2.3
7.0
84
479
J01DB01
ATC
cefalexin; oral
2.6
7.0
164
1284
M75.3
ICD-10 Finland
Calcific tendinitis of shoulder
23.4
6.7
9
*
M62.0
ICD-10 Finland
Diastasis of muscle
72.1
6.5
7
*
NDM40
NOMESCO Finland
Discission of sheath of tendon of wrist or hand
+∞
6.3
6
*
Z01.8
ICD-10 Finland
Other specified special examinations
2.7
6.2
45
196
S76.3
ICD-10 Finland
Injury of muscle and tendon of the posterior muscle group at thigh level
13.1
6.1
10
8
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
98
576
2.24
7.88
3.3
2.9
—
—
—
0
0
39
159
2.76
6.89
8.8
8.6
1.9
0.9
mmol/l
0.91
32
124
43
185
2.64
6.85
10.3
8.1
—
—
—
0
0
213
1803
4.15
6.72
21.6
14.1
139.7
139.8
mmol/l
0.15
207
1754
213
1810
4.07
6.52
21.1
14.2
3.9
4.0
mmol/l
0.89
207
1759
138
973
2.07
6.52
6.8
4.6
6.7
6.7
mmol/l
0.06
131
902
162
1218
2.17
6.38
4.3
3.6
10.7
11.7
mm/h
0.44
153
1130
84
500
2.08
6.25
3.7
2.3
52.5
56.0
u/l
0.58
75
457
52
257
2.33
6.13
1.1
1.2
16.7
29.9
iu/ml
0.82
14
81
166
1272
2.15
6.05
5.4
3.7
14.8
14.8
pmol/l
0.02
153
1156
49
238
2.35
6.00
1.2
1.2
1.4
9.3
u/ml
1.97
20
93
169
1307
2.16
5.96
8.4
7.4
81.0
77.0
u/l
0.59
160
1230
114
777
1.94
5.65
8.7
6.4
1.2
1.2
mmol/l
0.11
99
654
95
611
1.96
5.56
4.3
3.7
25.7
50.0
ng/l
1.43
66
405
62
342
2.12
5.55
1.8
1.6
1.3
1.2
mg/l
0.10
53
271
191
1572
2.39
5.47
6.0
4.3
2.0
1.9
mu/l
0.32
176
1432
205
1751
2.84
5.26
18.7
12.6
24.9
24.6
mg/l
0.03
177
1358
111
770
1.87
5.04
5.5
3.8
—
—
—
0
0
103
707
1.84
4.76
7.2
5.7
1.2
1.2
mmol/l
0.07
91
648
33
149
2.42
4.72
4.7
3.2
2.3
1.9
mmol/l
0.22
26
112
73
451
1.91
4.68
3.5
2.8
0.7
0.6
e6/l
0.15
64
333
23
88
2.80
4.56
11.9
12.1
92.0
94.1
%
0.40
23
88
111
789
1.80
4.50
4.4
3.1
0.0
0.0
estimate
0.00
20
157
196
1671
2.30
4.49
15.7
11.8
84.2
82.0
ml/min/173m2
0.86
175
1379
94
638
1.81
4.43
2.0
2.2
74.2
74.2
nmol/l
0.00
86
580
71
443
1.88
4.38
3.1
3.4
1367.9
1372.2
ng/l
0.00
62
372
74
468
1.86
4.37
2.3
2.0
170.6
177.5
u/l
0.07
69
437
199
1713
2.35
4.36
4.7
4.2
6.0
5.9
mmol/l
0.37
185
1580
49
272
2.02
4.23
1.9
1.8
1313.9
1201.1
nmol/l
0.32
40
210
100
700
1.77
4.19
6.5
4.6
35.8
35.8
g/l
0.01
93
659
20
75
2.83
4.11
6.0
3.1
25.4
24.6
mmol/l
0.52
20
75
92
632
1.77
4.10
4.8
3.3
—
—
—
0
0
152
1207
1.79
4.05
3.5
2.9
48.7
47.2
u/l
0.09
140
1142
88
602
1.76
3.94
2.3
1.9
103.1
94.1
pmol/l
0.64
44
321
15
49
3.21
3.88
1.8
1.5
—
—
—
0
0
109
797
1.71
3.82
4.8
3.2
0.0
0.0
estimate
0.00
21
145
108
788
1.71
3.81
6.5
4.4
0.0
0.0
estimate
0.00
21
158
39
208
2.06
3.74
28.0
20.2
1.0
1.3
inr
—
7
35
212
1907
2.80
3.68
12.3
9.4
28.2
26.4
u/l
0.67
207
1841
16
57
2.94
3.60
2.2
1.7
0.8
2.6
ug/l
0.53
16
46
187
1615
1.91
3.40
6.0
5.3
39.7
39.6
mmol/mol
0.04
175
1513
64
416
1.75
3.35
3.2
2.5
328.7
7291.5
umol/l
2.02
57
361
25
118
2.26
3.24
9.6
8.2
9.4
9.6
mmol/l
0.05
25
111
21
92
2.41
3.21
2.3
3.2
3.0
1.4
mmol/l
0.91
16
74
82
577
1.66
3.19
3.1
3.2
35.4
32.5
u/l
0.23
74
557
114
873
1.62
3.16
7.8
6.5
11.0
11.5
umol/l
0.29
106
832
45
270
1.83
3.06
3.0
2.4
0.8
1.1
e6/l
0.48
30
153
26
129
2.15
3.00
3.2
2.4
70.3
64.9
ml/min/173m2
0.28
11
58
71
494
1.64
2.84
3.5
3.8
16.0
10.6
mg/mmol
0.34
45
315
199
1783
1.97
2.83
4.8
4.1
4.5
4.7
mmol/l
0.82
185
1666
97
730
1.58
2.80
3.4
2.6
145.7
128.5
ug/l
0.24
91
678
201
1810
2.00
2.77
5.2
4.5
2.7
2.8
mmol/l
0.48
186
1680
84
614
1.59
2.73
5.1
4.6
1.6
2.9
ug/l
1.11
77
551
62
422
1.65
2.69
4.5
3.5
0.0
0.0
estimate
0.00
19
149
137
1122
1.56
2.68
3.7
3.1
—
—
—
0
0
197
1769
1.89
2.64
4.9
4.1
1.4
1.4
mmol/l
1.69
183
1643
20
96
2.19
2.51
1.3
1.4
—
—
—
0
0
21
103
2.15
2.51
2.8
3.0
5.1
5.1
kpa
0.11
21
95
12
45
2.76
2.49
1.5
1.6
—
—
—
0
0
10
34
3.03
2.44
1.2
1.1
—
—
—
0
0
22
112
2.07
2.40
1.3
1.3
86.3
163.2
iu/ml
0.68
11
46
30
171
1.87
2.39
2.2
1.7
—
—
—
0
0
30
173
1.85
2.31
2.2
1.8
—
—
—
0
0
46
301
1.66
2.30
4.8
3.4
1388.1
360.7
ng/l
0.37
34
237
170
1486
1.58
2.30
20.0
15.5
13.7
13.7
%
0.14
165
1459
9
29
3.19
2.25
1.2
1.4
—
—
—
0
0
40
254
1.70
2.24
3.4
2.6
6.2
1.9
e6/l
0.58
26
139
40
254
1.70
2.24
2.4
1.8
—
—
—
0
0
190
1710
1.70
2.23
4.5
3.7
1.4
1.3
mmol/l
0.75
176
1581
57
397
1.58
2.22
2.6
2.0
—
—
—
0
0
9
31
2.98
2.09
1.2
1.6
—
—
—
0
0
185
1667
1.61
2.01
18.4
13.4
39.8
40.4
%
0.30
123
1258
72
540
1.49
1.99
3.7
3.7
2.3
2.3
mmol/l
0.06
66
493
45
306
1.59
1.93
1.7
1.5
—
—
—
0
0
34
216
1.68
1.90
2.8
2.3
2.3
2.3
g/l
0.08
34
197
9
35
2.64
1.82
1.7
1.1
—
—
—
0
0
117
976
1.41
1.80
10.7
9.6
4.0
4.1
e9/l
0.15
101
856
10
41
2.51
1.78
2.8
2.2
705.4
209.3
ug/l
—
10
41
30
189
1.68
1.74
5.1
4.4
30.7
31.1
%
0.06
23
120
5
13
3.91
1.72
1.2
1.1
—
—
—
0
0
15
77
2.02
1.63
3.8
2.3
1.5
1.2
%
0.49
15
77
27
172
1.65
1.51
3.5
3.5
—
—
—
0
0
63
490
1.40
1.40
4.6
4.1
23.3
20.5
%
0.73
29
217
11
54
2.09
1.35
2.4
3.1
—
—
—
0
0
19
115
1.71
1.29
3.3
3.0
138.1
163.9
ng/l
0.25
19
98
47
353
1.42
1.27
1.9
1.7
435.3
13245454.6
pmol/l
0.50
40
302
11
56
2.01
1.24
1.0
1.8
—
—
—
0
0
11
56
2.01
1.24
1.0
1.8
4.2
3.8
g/l
—
6
35
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
10
49
2.09
1.24
5.7
2.0
0.2
0.3
u/ml
—
5
26
14
79
1.82
1.20
1.5
1.3
—
—
—
0
0
10
50
2.05
1.18
1.2
1.1
—
—
—
0
0
10
50
2.05
1.18
1.2
1.1
—
—
—
0
0
44
333
1.40
1.14
1.3
1.2
6.5
0.9
u/ml
0.44
13
92
18
112
1.66
1.13
2.4
1.3
—
—
—
0
0
14
82
1.75
1.08
3.1
3.0
24.4
24.1
mmol/l
0.09
14
74
7
33
2.16
1.06
3.6
1.8
—
—
—
0
0
7
34
2.09
1.04
1.0
1.1
—
—
—
0
0
5
23
2.20
0.98
2.0
1.6
—
—
—
0
0
24
167
1.49
0.97
5.9
4.9
231.8
252.6
u/l
0.31
24
157
6
30
2.03
0.87
1.7
1.7
—
—
—
0
0
8
44
1.85
0.87
2.6
2.3
24.7
25.0
mmol/l
—
8
36
44
350
1.32
0.85
3.4
2.8
0.7
0.7
ug/l
0.07
25
223
6
32
1.90
0.82
1.8
1.7
—
—
—
0
0
6
34
1.79
0.77
1.5
1.1
—
—
—
0
0
5
24
2.11
0.75
1.8
1.7
—
—
—
0
0
7
40
1.77
0.72
1.0
2.0
0.0
0.0
g/l
—
7
35
56
471
1.25
0.71
1.6
1.6
1.3
1.4
mmol/l
0.54
42
402
18
127
1.45
0.70
3.8
4.2
1.2
1.2
mmol/l
0.15
13
113
7
42
1.69
0.69
1.6
1.7
—
—
—
0
0
21
156
1.38
0.64
1.6
1.8
—
—
—
0
0
5
30
1.68
0.62
2.0
1.6
—
—
—
0
0
8
52
1.56
0.60
1.1
1.3
—
—
—
0
0
6
35
1.73
0.58
1.0
1.9
0.0
0.0
g/l
—
6
30
6
35
1.73
0.58
1.2
1.2
—
—
—
0
0
6
36
1.68
0.57
1.3
1.0
—
—
—
0
0
12
83
1.47
0.53
3.1
1.6
—
—
—
0
0
7
48
1.47
0.47
1.0
2.3
0.0
2.4
g/l
—
7
40
7
50
1.41
0.45
1.0
1.5
—
—
—
0
0
5
32
1.57
0.42
1.2
1.2
—
—
—
0
0
8
59
1.37
0.41
1.9
1.7
—
—
—
0
0
5
34
1.48
0.40
1.2
1.7
—
—
—
0
0
11
81
1.38
0.37
1.0
1.0
—
—
—
0
0
6
43
1.41
0.35
1.0
1.8
36.3
38.6
g/l
—
6
33
7
54
1.31
0.30
1.1
1.6
—
—
—
0
0
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
0
11
0.00
0.21
0.0
2.5
—
—
—
0
0
0
11
0.00
0.21
0.0
1.3
—
9.1
—
0
11
0
13
0.00
0.21
0.0
1.6
—
—
—
0
0
0
13
0.00
0.21
0.0
1.0
—
—
—
0
0
0
14
0.00
0.20
0.0
3.7
—
—
—
0
0
18
158
1.15
0.17
2.5
2.1
31.6
34.8
u/l
0.22
13
138
20
179
1.13
0.14
1.8
1.9
—
—
—
0
0
17
187
0.90
0.10
1.4
1.7
—
—
—
0
0
5
48
1.04
0.09
3.0
4.3
37.3
32.1
mg/l
—
5
36
5
48
1.04
0.09
2.8
4.2
—
1.1
—
0
7
5
48
1.04
0.09
3.0
4.3
55.6
72.5
mg/l
—
5
36
6
58
1.04
0.08
1.7
1.4
279.2
319.3
mu/l
—
6
53
5
65
0.76
0.08
4.0
1.7
—
—
—
0
0
26
261
1.00
0.00
1.7
1.5
—
—
—
0
0
10
97
1.03
0.00
1.6
1.9
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
29.2
—
0
6
0
9
0.00
0.00
0.0
1.1
—
—
—
0
0
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
0.00
0.0
1.8
—
14.3
—
0
9
0
9
0.00
0.00
0.0
1.1
—
—
—
0
0
0
9
0.00
0.00
0.0
1.8
—
—
—
0
0
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
2.2
—
—
—
0
0
0
9
0.00
0.00
0.0
1.1
—
—
—
0
0
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
0.00
0.0
1.1
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
9
0.00
0.00
0.0
1.4
—
—
—
0
0
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
0
9
0.00
0.00
0.0
1.1
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
8
86
0.93
0.00
1.5
1.6
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
8
79
1.01
0.00
1.3
1.8
—
—
—
0
0
0
8
0.00
0.00
0.0
1.3
—
—
—
0
0
5
49
1.02
0.00
2.4
1.9
—
—
—
0
0
0
5
0.00
0.00
0.0
2.6
—
—
—
0
0
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
5
54
0.92
0.00
1.2
1.4
—
—
—
0
0
0
8
0.00
0.00
0.0
1.3
—
—
—
0
0
6
69
0.87
0.00
3.5
1.7
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint M13_RUPTUREMUSC and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_RUPTUREMUSC | 1.322 [1.05, 1.67] | 0.019 |
| Birth year | 0.999 [0.99, 1.01] | 0.778 |
During the follow-up period (1.1.1998 — 31.12.2019), 96 out of 564 females with M13_RUPTUREMUSC died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_RUPTUREMUSC | 1.218 [1.01, 1.46] | 0.036 |
| Birth year | 0.992 [0.98, 1.0] | 0.09 |
During the follow-up period (1.1.1998 — 31.12.2019), 150 out of 748 males with M13_RUPTUREMUSC died.
Mortality risk
Mortality risk for people of age
years, who have M13_RUPTUREMUSC.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.121% | 0.238% |
| 5 | 0.7% | 1.591% |
| 10 | 1.947% | 4.175% |
| 15 | 4.052% | 7.574% |
| 20 | 7.25% | 13.317% |
Relationships between endpoints
↥Index endpoint: M13_RUPTUREMUSC – Other rupture of muscle
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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