muscular disease: Acquired, familial, and congenital disorders of skeletal muscle and smooth muscle.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
226 |
4. Check minimum number of eventsNone |
226 |
5. Include endpointsNone |
226 |
6. Filter based on genotype QC (FinnGen only) |
226 |
Control definitions (FinnGen only)
- Control exclude
- M13_SOFTTISSUE
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- M62
- Name in latin
- Ruptura musculi non traumatica
Similar endpoints
↥List of similar endpoints to
Other rupture of muscle
based on the number of shared cases.
Similar with more cases:
- Disorders of muscles
- Soft tissue disorders
- Diseases of the musculoskeletal system and connective tissue
- Any operation in hilmo
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1604 | 713 | 883 |
| Only index persons | 1502 | 672 | 830 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.02 | 0.02 | 0.02 |
| Only index persons | 0.03 | 0.02 | 0.03 |
| Median age at first event (years) | |||
| Whole population | 53.09 | 53.57 | 52.63 |
| Only index persons | 52.22 | 52.43 | 52.04 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 226 | 114 | 112 |
| Unadjusted period prevalence (%) | 0.04 | 0.04 | 0.05 |
| Median age at first event (years) | 53.87 | 51.14 | 56.65 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 198
- Matched controls
- 1981
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
M62.1
ICD-10 Finland
Other rupture of muscle (nontraumatic)
+∞
286.6
198
*
M79.6
ICD-10 Finland
Pain in limb
4.3
17.8
80
267
M75.1
ICD-10 Finland
Rotator cuff syndrome
5.3
16.0
53
127
QBJ30
NOMESCO Finland
Correction of abdominal apron
53.8
13.0
15
*
N02BE01
ATC
paracetamol; systemic, rectal
3.5
9.3
175
1355
M79.1
ICD-10 Finland
Myalgia
4.5
9.2
33
84
X58
ICD-10 Finland
Exposure to other specified factors
4.0
9.1
38
112
S46.0
ICD-10 Finland
Injury of muscle(s) and tendon(s) of the rotator cuff of shoulder
6.2
8.8
23
41
N02AJ06
ATC
codeine and paracetamol; systemic
2.6
8.7
83
430
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
2.7
8.5
73
357
K42.9
ICD-10 Finland
Umbilical hernia without obstruction or gangrene
6.2
8.4
22
39
N03AX16
ATC
pregabalin; oral
3.1
8.3
50
195
NBG15
NOMESCO Finland
Acromioplastia, arthroscopic
18.1
8.2
12
7
M76.6
ICD-10 Finland
Achilles tendinitis
10.0
7.9
15
16
N03AX12
ATC
gabapentin; oral
3.8
7.8
33
98
M75.4
ICD-10 Finland
Impingement syndrome of shoulder
10.7
7.7
14
14
K43.9
ICD-10 Finland
Other and unspecified ventral hernia without obstruction or gangrene
6.5
7.6
19
32
M79.2
ICD-10 Finland
Neuralgia and neuritis, unspecified
83.1
7.5
8
*
M79.0
ICD-10 Finland
Rheumatism, unspecified
83.1
7.5
8
*
N02AX02
ATC
tramadol; systemic, rectal
2.4
7.4
86
483
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
2.3
7.2
94
560
S18
ICPC
Laceration/cut
2.3
7.0
84
479
J01DB01
ATC
cefalexin; oral
2.6
7.0
164
1284
M75.3
ICD-10 Finland
Calcific tendinitis of shoulder
23.4
6.7
9
*
M62.0
ICD-10 Finland
Diastasis of muscle
72.1
6.5
7
*
NDM40
NOMESCO Finland
Discission of sheath of tendon of wrist or hand
+∞
6.3
6
*
Z01.8
ICD-10 Finland
Other specified special examinations
2.7
6.2
45
196
S76.3
ICD-10 Finland
Injury of muscle and tendon of the posterior muscle group at thigh level
13.1
6.1
10
8
Mortality – FinRegistry
↥Association
Association between endpoint M13_RUPTUREMUSC and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_RUPTUREMUSC | 1.322 [1.05, 1.67] | 0.019 |
| Birth year | 0.999 [0.99, 1.01] | 0.778 |
During the follow-up period (1.1.1998 — 31.12.2019), 96 out of 564 females with M13_RUPTUREMUSC died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_RUPTUREMUSC | 1.218 [1.01, 1.46] | 0.036 |
| Birth year | 0.992 [0.98, 1.0] | 0.09 |
During the follow-up period (1.1.1998 — 31.12.2019), 150 out of 748 males with M13_RUPTUREMUSC died.
Mortality risk
Mortality risk for people of age
years, who have M13_RUPTUREMUSC.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.121% | 0.238% |
| 5 | 0.7% | 1.591% |
| 10 | 1.947% | 4.175% |
| 15 | 4.052% | 7.574% |
| 20 | 7.25% | 13.317% |
Relationships between endpoints
↥Index endpoint: M13_RUPTUREMUSC – Other rupture of muscle
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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