No definition available.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519972 |
1. Apply sex-specific ruleNone |
519972 |
2. Check conditionsNone |
519972 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
295 |
4. Check minimum number of eventsNone |
295 |
5. Include endpointsNone |
295 |
6. Filter based on genotype QC (FinnGen only) |
283 |
Control definitions (FinnGen only)
- Control exclude
- M13_ARTHROPATHIES
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- M21
- Name in latin
- Deformitas membri valga non alibi classificata
Similar endpoints
↥List of similar endpoints to
Valgus deformity, not elsewhere classified
based on the number of shared cases.
Similar with more cases:
- Other joint disorders
- Arthropathies
- Diseases of the musculoskeletal system and connective tissue
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 2937 | 1838 | 1089 |
| Only index persons | 2579 | 1613 | 966 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.04 | 0.05 | 0.03 |
| Only index persons | 0.05 | 0.06 | 0.04 |
| Median age at first event (years) | |||
| Whole population | 35.31 | 47.23 | 14.96 |
| Only index persons | 34.02 | 45.33 | 15.13 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 283 | 200 | 83 |
| Unadjusted period prevalence (%) | 0.06 | 0.07 | 0.04 |
| Median age at first event (years) | 41.99 | 47.59 | 28.50 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 295
- Matched controls
- 2950
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
M21.0
ICD-10 Finland
Valgus deformity, not elsewhere classified
10154.4
290.4
230
*
M20.1
ICD-10 Finland
Hallux valgus (acquired)
83.2
162.4
88
15
M17.1
ICD-10 Finland
Other primary gonarthrosis
28.5
110.7
80
38
M19.0
ICD-10 Finland
Primary arthrosis of other joints
37.8
83.0
53
17
NG1AA
NOMESCO Finland
Knee X-ray examination without contrast
16.4
69.6
64
49
M17.0
ICD-10 Finland
Primary gonarthrosis, bilateral
26.5
68.2
49
22
NJ2MA
NOMESCO Finland
Measurement of mechanical axis of lower leg with X-ray
+∞
54.9
51
*
M20.4
ICD-10 Finland
Other hammer toe(s) (acquired)
134.6
52.8
55
5
NHK30
NOMESCO Finland
Osteotomy or rotation osteotomy of first metatarsal or tarsal bone
+∞
46.1
43
*
NGD05
NOMESCO Finland
Partial excision of meniscus of knee, arthroscopic
16.4
39.7
35
24
NGB20
NOMESCO Finland
Primary total prosthetic replacement of knee joint without patellar part
+∞
36.2
34
*
NH3AA
NOMESCO Finland
Foot and toes X-ray examination
10.0
35.8
44
51
M21.4
ICD-10 Finland
Flat foot [pes planus] (acquired)
65.8
35.2
40
7
NHG80
NOMESCO Finland
Fusion of first tarsometatarsal joint
+∞
34.0
32
*
M25.5
ICD-10 Finland
Pain in joint
4.3
30.5
108
347
NHK40
NOMESCO Finland
Osteotomy or rotation osteotomy of II-V metatarsal or tarsal bone
+∞
28.6
27
*
WX320
NOMESCO Finland
Spinalanesthesy
4.5
27.1
81
227
M23.2
ICD-10 Finland
Derangement of meniscus due to old tear or injury
66.5
26.5
30
5
M01AX05
ATC
glucosamine; oral
5.0
26.4
66
160
N03AX12
ATC
[U] gabapentin; oral
4.8
25.4
68
174
73802
ICD-8 Finland
Other deformities, Genu valgum
+∞
25.4
24
*
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
3.3
22.6
142
646
N02AX02
ATC
tramadol; systemic, rectal
3.3
22.4
138
620
NHU20
NOMESCO Finland
Removal of internal fixation device from ankle or foot
22.2
22.2
32
16
NHG77
NOMESCO Finland
Arthroplasty of interphalangeal tarsal joint(s)
+∞
22.2
21
*
ZXA00
NOMESCO Finland
Right side
3.6
22.0
95
341
L15
ICPC
Knee symptom/complaint
3.8
21.9
87
296
ZXA05
NOMESCO Finland
Left side
3.6
20.8
88
311
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
7.5
19.9
30
44
NHG26
NOMESCO Finland
Fusion between bones of ankle or ankle and foot
+∞
19.0
18
*
NGU20
NOMESCO Finland
Removal of internal fixation device from knee or lower leg
41.3
18.8
23
6
M79.6
ICD-10 Finland
Pain in limb
3.0
18.6
139
681
M13.9
ICD-10 Finland
Arthritis, unspecified
18.1
18.3
28
17
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
4.5
17.9
49
126
M23.9
ICD-10 Finland
Internal derangement of knee, unspecified
5.6
17.4
35
69
M51.3
ICD-10 Finland
Other specified intervertebral disc degeneration
6.1
17.4
32
58
NGF25
NOMESCO Finland
Operation for osteochondritis of knee, arthroscopic
27.5
17.2
23
9
M01AH05
ATC
etoricoxib; oral
2.9
17.1
183
1071
NH3FA
NOMESCO Finland
Weight-bearing X-ray of foot
67.4
16.9
19
*
TNX10
NOMESCO Finland
Arthrocentesis, unspecified region, unspecified region
17.7
16.9
26
16
NA3BG
NOMESCO Finland
Lumbar spine MRI examination with high intensity magnet
5.5
16.9
35
71
NFK30
NOMESCO Finland
Angulation, rotation or displacement osteotomy of femur
+∞
16.8
16
*
M16.1
ICD-10 Finland
Other primary coxarthrosis
15.7
16.2
26
18
N02AJ06
ATC
codeine and paracetamol; systemic
2.8
16.1
131
660
L04AX03
ATC
methotrexate; systemic
7.7
15.9
23
32
L17
ICPC
Foot/toe symptom/complaint
2.9
15.7
105
476
M17.3
ICD-10 Finland
Other post-traumatic gonarthrosis
90.0
15.7
17
*
M20.2
ICD-10 Finland
Hallux rigidus
90.0
15.7
17
*
TNX33
NOMESCO Finland
Custom moulded cast, unspecified region
6.1
15.4
28
50
B01AF01
ATC
rivaroxaban; oral
4.7
15.3
38
90
NFU20
NOMESCO Finland
Removal of internal fixation device from femur
33.7
15.0
19
6
N03AX16
ATC
[U] pregabalin
3.1
14.7
74
285
NHG70
NOMESCO Finland
Arthroplasty of first tarsometatarsal joint
+∞
14.7
14
*
NHL68
NOMESCO Finland
Tenodesis, shortening or lengthening of tendon of foot
+∞
14.7
14
*
R5110, ,
SPAT
5.6
14.7
29
56
M17.9
ICD-10 Finland
Gonarthrosis, unspecified
5.1
14.1
31
66
NGA30
NOMESCO Finland
Exploration of knee joint, arthroscopic
31.8
14.0
18
6
S18
ICPC
Laceration/cut
2.5
13.7
143
798
NFK20
NOMESCO Finland
Epiphysiodesis of femur
78.9
13.7
15
*
73800
ICD-8 Finland
Other deformities, Coxa valga
+∞
13.6
13
*
NH3DA
NOMESCO Finland
Bilateral foot X-ray examination
+∞
13.6
13
*
9271
FHL
Hallux surgery
+∞
13.6
13
*
7364A
ICD-9 Finland
Other acquired deformities of limbs, Genu valgum or varum (acquired)[GENU VALGUM ACQUISITUM]
+∞
13.6
13
*
M19.1
ICD-10 Finland
Post-traumatic arthrosis of other joints
+∞
13.6
13
*
NHG82
NOMESCO Finland
Fusion of other tarsal joint
+∞
13.6
13
*
B01AB05
ATC
enoxaparin; parenteral
2.8
13.2
87
387
E66.00
ICD-10 Finland
Metabolic syndrome
5.2
13.1
28
58
X59
ICD-10 Finland
Exposure to unspecified factor
3.0
13.1
67
260
L28
ICPC
Limited function/disability (L)
3.3
13.1
57
201
WX702
NOMESCO Finland
Supraglottic ventilation device
4.8
13.0
31
71
WX111
NOMESCO Finland
Local infiltration anesthesia
+∞
12.6
12
*
NGB40
NOMESCO Finland
Primary total prosthetic replacement of knee joint with patellar part - sliding prosthesis
+∞
12.6
12
*
SPAT1230
SPAT
Aid fitting and borrowing and monitoring of use
3.2
12.1
54
193
P01BA02
ATC
hydroxychloroquine; oral
12.5
12.0
21
18
NH3EA
NOMESCO Finland
Feet X-ray examination with load
48.8
12.0
14
*
M18.1
ICD-10 Finland
Other primary arthrosis of first carpometacarpal joint
48.8
12.0
14
*
Z50.9
ICD-10 Finland
Care involving use of rehabilitation procedure, unspecified
6.2
12.0
21
36
NHG24
NOMESCO Finland
Fusion of subtalar joint and between bones of ankle
+∞
11.5
11
*
NG1DA
NOMESCO Finland
X-ray of knees
124.7
11.5
12
*
M16.0
ICD-10 Finland
Primary coxarthrosis, bilateral
11.2
11.5
21
20
N06AX21
ATC
duloxetine; oral
3.4
11.4
46
154
NK4XE
NOMESCO Finland
Joint ultrasound examination not elsewhere classified
21.0
11.3
16
8
SPAT1223
SPAT
Implementation of physical therapy rehabilitation plan
2.5
11.1
88
425
TNX50
NOMESCO Finland
Removal of cutom molded cast and internal stretch
5.3
10.7
22
44
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
3.8
10.7
34
97
H02AB06
ATC
prednisolone; systemic
2.3
10.7
133
782
M01AH01
ATC
celecoxib; oral
3.0
10.6
51
190
M21.1
ICD-10 Finland
Varus deformity, not elsewhere classified
+∞
10.5
10
*
7151F
ICD-9 Finland
Osteo-arthrosis and allied disorders, Osteo-arthrosis, localised, primary[OSTEOARTHROSIS PRIMARIA, POLVI]
+∞
10.5
10
*
M22.0
ICD-10 Finland
Recurrent dislocation of patella
+∞
10.5
10
*
7350A
ICD-9 Finland
Acquired deformities of toe, Hallux valgus (acquired)
+∞
10.5
10
*
M19.2
ICD-10 Finland
Other secondary arthrosis
+∞
10.5
10
*
NHK99
NOMESCO Finland
Other operation on bone of ankle or foot
33.9
10.4
13
*
R03BA01
ATC
beclometasone; inhalant
3.0
10.3
51
193
E66.01
ICD-10 Finland
Obesity due to excess calories
3.5
10.3
37
115
NH3BA
NOMESCO Finland
Foot and toes extensive X-ray examination
11.9
10.2
18
16
M01AB05
ATC
diclofenac; systemic, rectal
2.2
10.1
183
1243
NFB30
NOMESCO Finland
Primary total prosthetic replacement of hip joint not using cement
41.6
10.0
12
*
M67.0
ICD-10 Finland
Short Achilles tendon (acquired)
41.6
10.0
12
*
NGF35
NOMESCO Finland
Plastic operation of joint cartilage of knee
41.6
10.0
12
*
NG2AA
NOMESCO Finland
Patella X-ray examination
41.6
10.0
12
*
TQW40
NOMESCO Finland
Remowal of suture of skin
4.3
10.0
27
68
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
2.4
10.0
95
496
N06AA09
ATC
amitriptyline; systemic
3.8
9.9
32
92
M17
ICD-10 Finland
Gonarthrosis [arthrosis of knee]
4.5
9.8
25
60
NHL14
NOMESCO Finland
Shortening or lengthening of achilles tendon
103.2
9.5
10
*
M77.4
ICD-10 Finland
Metatarsalgia
4.3
9.4
25
62
NGK30
NOMESCO Finland
Angulation, rotation or displacement osteotomy of knee or lower leg
+∞
9.4
9
*
7363A
ICD-9 Finland
Other acquired deformities of limbs, Acquired deformities of hip[COXA VALGA ACQUISITA]
+∞
9.4
9
*
J01FF01
ATC
clindamycin; systemic
2.4
9.4
83
418
Y83
ICD-10 Finland
Surgical operation and other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
4.2
9.4
26
67
ND2AA
NOMESCO Finland
Hand and fingers X-ray examination
3.7
9.2
30
87
M01AX17
ATC
nimesulide; oral
2.5
9.1
64
290
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
2.1
9.0
130
797
Z96.6
ICD-10 Finland
Presence of orthopaedic joint implants
24.9
9.0
12
5
NFB40
NOMESCO Finland
Primary total prosthetic replacement of hip joint using hybrid technique
24.9
9.0
12
5
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
3.3
8.9
36
120
A02BC05
ATC
esomeprazole; systemic
2.2
8.8
113
660
M54.5
ICD-10 Finland
Low back pain
2.2
8.7
99
551
NHL99
NOMESCO Finland
Other operation on muscle or tendon of ankle or foot
51.6
8.7
10
*
NH1AA
NOMESCO Finland
Ankle X-ray examination without contrast
3.9
8.7
26
71
N02BE01
ATC
paracetamol; systemic, rectal
2.9
8.6
258
2094
NH1BG
NOMESCO Finland
Ankle and foot MRI examination with high intensity magnet
20.8
8.5
12
6
M05.8
ICD-10 Finland
Other seropositive rheumatoid arthritis
92.6
8.5
9
*
1221
FHL
Arthroscopy and meniscus surgery
92.6
8.5
9
*
M23.3
ICD-10 Finland
Other meniscus derangements
92.6
8.5
9
*
9273
FHL
Other surgery for toe deformity or pain condition, e.g., Morton, hammer toe
+∞
8.4
8
*
NHG76
NOMESCO Finland
Arthroplasty of other tarsometatarsal joint
+∞
8.4
8
*
NHG22
NOMESCO Finland
Fusion of subtalar joint
+∞
8.4
8
*
Q74.1
ICD-10 Finland
Congenital malformation of knee
+∞
8.4
8
*
M21.7
ICD-10 Finland
Unequal limb length (acquired)
+∞
8.4
8
*
H02AB04
ATC
methylprednisolone; systemic
2.9
8.3
43
166
M70.6
ICD-10 Finland
Trochanteric bursitis
2.9
8.2
40
149
M51.1
ICD-10 Finland
Lumbar and other intervertebral disc disorders with radiculopathy
2.9
8.2
42
161
J46
ICD-10 Finland
Status asthmaticus
9.3
8.1
16
18
N02BF02
ATC
pregabalin; oral
4.5
8.1
20
47
S83.6
ICD-10 Finland
Sprain and strain of other and unspecified parts of knee
4.2
8.0
22
56
SAA01
NOMESCO Finland
Simple examination of mouth
2.2
8.0
221
1697
NF1AA
NOMESCO Finland
Hip X-ray examination
4.3
7.9
21
52
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
3.5
7.9
28
86
NG1BG
NOMESCO Finland
Knee and lower leg MRI examination with high intensity magnet
11.2
7.9
14
13
M19.8
ICD-10 Finland
Other specified arthrosis
7.8
7.8
17
23
J01DA01
ATC
[U] cefalexin
2.0
7.8
178
1269
T81.4
ICD-10 Finland
Infection following a procedure, not elsewhere classified
3.1
7.8
34
119
M02AA07
ATC
piroxicam; topical
2.1
7.8
97
557
J45.9
ICD-10 Finland
Asthma, unspecified
2.4
7.7
61
290
I83.9
ICD-10 Finland
Varicose veins of lower extremities without ulcer or inflammation
3.0
7.7
36
131
SPAT1229
SPAT
Assessment of need for aid
3.8
7.6
24
68
SPAT1148
SPAT
Treatment of chronic ulcer or burn
2.7
7.4
41
164
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
2.1
7.3
95
551
M17.5
ICD-10 Finland
Other secondary gonarthrosis
+∞
7.3
7
*
NHK68
NOMESCO Finland
Shortening or lengthening osteotomy of ankle or foot
+∞
7.3
7
*
NH1EA
NOMESCO Finland
Ankle X-ray examination with load or wrench
+∞
7.3
7
*
7360A
ICD-9 Finland
Other acquired deformities of limbs, Acquired deformities of forearm, excluding fingers[CUBITUS VALGUS ACQUISITUS]
+∞
7.3
7
*
Z03.9
ICD-10 Finland
Observation for suspected disease or condition, unspecified
2.4
7.3
58
276
M35.7
ICD-10 Finland
Hypermobility syndrome
16.2
7.3
11
7
A02BC02
ATC
pantoprazole; systemic
2.0
7.2
178
1288
SGA01
NOMESCO Finland
Emergency treatment
2.5
7.2
51
230
L90
ICPC
Osteoarthrosis of knee
8.3
7.2
15
19
TNX32
NOMESCO Finland
Custom moulded splint, unspecified region
4.3
7.2
19
47
L88
ICPC
Rheumatoid/seropositive arthritis
30.8
7.2
9
*
TNX92
NOMESCO Finland
Supporting bandage or orthosis of lower limb
20.6
7.2
10
5
T84.0
ICD-10 Finland
Mechanical complication of internal joint prosthesis
20.6
7.2
10
5
L12
ICPC
Hand/finger symptom/complaint
2.4
7.2
53
244
N02BF01
ATC
gabapentin; oral
3.5
7.1
25
76
L08
ICPC
Shoulder symptom/complaint
2.3
7.1
61
301
R01AD12
ATC
fluticasone furoate; nasal
2.0
7.1
95
558
X58
ICD-10 Finland
Exposure to other specified factors
2.6
7.0
45
194
J01.0
ICD-10 Finland
Acute maxillary sinusitis
2.2
7.0
74
397
R4110
NOMESCO Finland
Physiotherapy
2.1
7.0
77
420
SAA02
NOMESCO Finland
Basic examination of mouth
2.0
7.0
206
1579
ZXE10
NOMESCO Finland
More than one and less than three hours
2.0
6.9
100
603
B01AB04
ATC
dalteparin; parenteral
4.4
6.8
17
40
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
2.5
6.8
48
216
NH1CG
NOMESCO Finland
Ankle and foot extensive MRI examination with high intensity magnet
41.0
6.8
8
*
M75.1
ICD-10 Finland
Rotator cuff syndrome
2.2
6.8
65
335
SPAT1144
SPAT
Treatment of reopened or infected surgical wound
3.4
6.7
25
79
WX404
NOMESCO Finland
Intravenous generell anesthesy
2.2
6.7
63
321
L13
ICPC
Hip symptom/complaint
2.5
6.7
47
211
Z01.5
ICD-10 Finland
Diagnostic skin and sensitization tests
2.8
6.6
34
131
TPH04
NOMESCO Finland
Cathetrisation of vein
2.2
6.5
64
332
A02BC01
ATC
omeprazole; systemic
2.1
6.5
76
422
Q66.0
ICD-10 Finland
Talipes equinovarus
71.3
6.5
7
*
9481
FHL
Detachment or severance of a muscle or tendon
71.3
6.5
7
*
M10.9
ICD-10 Finland
Gout, unspecified
6.2
6.4
16
27
M01AC06
ATC
meloxicam; systemic, rectal
2.0
6.4
92
551
J01AA02
ATC
doxycycline; systemic
2.0
6.4
208
1623
EB1AA
NOMESCO Finland
Intraoral radiographic dental examination
1.9
6.3
156
1111
L29
ICPC
Musculoskeletal sympt/complt other
2.9
6.3
30
110
Z3226
NOMESCO Finland
Physiotherapist
2.3
6.3
54
265
M54.4
ICD-10 Finland
Lumbago with sciatica
2.4
6.3
48
224
NDG71
NOMESCO Finland
Arthrodes of first MP joint
+∞
6.3
6
*
M05.9
ICD-10 Finland
Seropositive rheumatoid arthritis, unspecified
+∞
6.3
6
*
NDG60
NOMESCO Finland
Arthroplasty of first CMC joint
+∞
6.3
6
*
7177A
ICD-9 Finland
Internal derangement of knee, Chondromalacia of patella
+∞
6.3
6
*
M25.0
ICD-10 Finland
Haemarthrosis
+∞
6.3
6
*
A01
ICPC
Pain general/multiple sites
3.0
6.3
29
105
R2130
NOMESCO Finland
Counselling and guidance which enhance independent living
2.9
6.2
30
111
M01AH02
ATC
rofecoxib; oral
2.8
6.2
31
117
SPAT1149
SPAT
Suture or treatment of traumatic wound
2.6
6.2
37
154
NG1CG
NOMESCO Finland
Knee and lower leg extensive MRI examination with high intensity magnet
12.9
6.1
10
8
M48.0
ICD-10 Finland
Spinal stenosis
3.0
6.1
27
95
Z3229
NOMESCO Finland
Other healthcare associate professional
3.0
6.1
28
101
R4110, ,
SPAT
3.0
6.1
28
101
A07EC01
ATC
sulfasalazine; oral, rectal
5.8
6.1
16
29
SPAT1295
SPAT
Other function in accordance with physical therapy nomenclature
4.0
6.1
17
44
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
165
934
2.74
16.11
2.5
2.5
—
—
—
0
0
65
252
3.03
12.67
1.3
1.1
20.93
1.32
u/ml
0.85
21
106
221
1558
2.67
12.26
4.8
3.2
10.16
10.73
mm/h
0.36
209
1412
68
285
2.80
11.42
1.3
1.2
17.06
15.34
iu/ml
0.11
19
86
140
896
2.07
8.53
12.4
10.7
1.20
1.19
inr
0.04
45
283
127
789
2.07
8.35
2.2
1.8
93.75
96.68
pmol/l
0.31
72
387
14
13
11.24
7.88
1.3
1.1
—
—
—
0
0
212
1646
2.02
6.83
7.2
7.1
79.49
77.94
u/l
0.20
205
1524
149
1037
1.88
6.60
10.3
6.9
1.22
1.22
mmol/l
0.10
130
884
78
455
1.97
5.77
1.6
1.4
21.90
21.82
nmol/l
0.02
72
382
167
1248
1.78
5.51
6.1
4.9
6.14
6.53
mmol/l
2.96
153
1144
128
886
1.79
5.49
2.9
2.4
76.15
76.35
nmol/l
0.03
115
784
111
739
1.80
5.40
3.1
3.2
24.59
93.26
ng/l
0.72
75
471
71
415
1.94
5.18
3.3
2.6
354.20
12893.89
umol/l
3.64
66
367
31
129
2.57
5.17
1.3
1.2
142.05
408.28
u/ml
0.78
26
116
121
841
1.74
5.00
5.8
5.5
35.87
36.03
g/l
0.12
110
788
268
2364
2.46
4.97
19.0
13.4
139.70
139.66
mmol/l
0.10
262
2289
132
943
1.72
4.93
10.0
6.2
1.22
1.22
mmol/l
0.23
119
868
149
1104
1.71
4.84
5.2
6.8
10.21
10.87
umol/l
0.52
142
1047
268
2371
2.42
4.81
19.0
13.5
3.93
3.94
mmol/l
0.36
261
2294
77
478
1.83
4.62
2.3
2.1
—
—
—
0
0
72
448
1.80
4.26
3.1
1.6
1.42
0.99
mg/l
0.64
53
334
163
1272
1.63
4.09
9.2
9.0
3.91
3.94
e9/l
0.05
143
1088
8
12
6.82
3.69
7.3
1.8
—
—
—
0
0
94
662
1.62
3.46
2.1
2.4
53.37
59.56
u/l
0.88
88
606
75
500
1.67
3.42
2.5
2.2
2.86
2.92
mg/l
0.09
67
409
101
728
1.59
3.36
5.1
2.9
—
—
—
0
0
256
2297
1.87
3.32
16.6
11.6
14.52
24.51
mg/l
9.00
210
1695
55
340
1.76
3.29
1.8
1.6
1149.22
1173.46
nmol/l
0.08
49
248
133
1028
1.53
3.23
4.1
2.6
85.92
101.41
ug/l
0.75
125
939
9
20
4.61
3.14
1.2
1.7
14.45
18.58
ug/l
—
9
20
11
30
3.77
3.12
1.6
1.2
4.60
3.42
u/ml
—
5
19
74
503
1.63
3.11
4.3
3.0
960.55
1159.51
ng/l
0.28
60
430
13
46
2.91
2.96
1.2
1.4
—
—
—
0
0
232
2047
1.62
2.93
5.6
4.9
37.61
39.01
mmol/mol
2.09
218
1878
81
572
1.57
2.89
1.4
1.3
1.47
3.04
u/ml
0.59
16
140
7
13
5.48
2.88
1.0
1.5
1.58
1.61
mmol/l
—
7
13
243
2173
1.67
2.86
5.6
4.5
1.79
1.93
mu/l
1.26
228
1982
47
289
1.74
2.86
3.9
2.3
15.57
14.05
umol/l
0.76
41
264
17
72
2.44
2.78
21.6
5.1
1.32
1.38
mg/l
0.12
17
66
15
61
2.54
2.66
1.3
1.2
—
—
—
0
0
10
30
3.41
2.63
1.3
1.1
—
—
—
0
0
246
2222
1.64
2.60
4.7
4.0
5.75
5.80
mmol/l
0.24
229
2018
32
181
1.86
2.56
14.9
4.2
5.45
4.65
kpa
0.61
32
175
79
572
1.52
2.49
3.9
3.7
7.75
9.35
mg/mmol
0.15
48
360
25
131
1.99
2.49
12.0
5.0
0.50
1.95
mmol/l
1.03
17
101
272
2534
1.94
2.47
11.3
8.5
26.20
24.91
u/l
0.46
266
2431
241
2182
1.57
2.35
14.3
10.4
85.41
84.86
ml/min/173m2
0.12
196
1743
35
210
1.76
2.33
14.3
4.7
6.02
5.83
kpa
0.67
35
204
43
277
1.65
2.22
4.4
3.7
31.63
31.54
%
0.02
27
178
47
310
1.61
2.21
4.7
2.7
3.72
3.06
e6/l
0.15
30
161
94
721
1.45
2.20
3.7
3.3
25.45
30.21
u/l
2.36
88
692
48
320
1.60
2.17
1.6
2.0
—
—
—
0
0
18
93
2.00
1.89
1.7
1.7
—
—
—
0
0
23
130
1.83
1.88
2.2
3.2
4.67
4.52
pmol/l
0.28
18
115
38
251
1.59
1.79
4.6
2.3
24.33
23.79
%
0.09
30
210
204
1825
1.38
1.79
4.8
3.8
14.90
14.72
pmol/l
0.51
183
1656
130
1090
1.34
1.72
5.7
3.2
0.00
0.00
estimate
-0.00
36
190
57
419
1.45
1.65
1.5
1.7
140000380.32
446.50
pmol/l
0.49
50
345
128
1082
1.32
1.57
7.0
4.4
0.00
0.01
estimate
0.50
37
194
281
2695
1.90
1.56
24.4
16.8
40.08
40.17
%
0.10
261
2525
281
2696
1.89
1.54
23.9
16.7
262.14
255.16
e9/l
0.98
274
2607
281
2699
1.87
1.49
23.9
16.7
4.51
4.51
e12/l
0.09
273
2612
127
1081
1.31
1.45
5.9
3.2
0.00
0.00
estimate
-0.00
37
203
9
39
2.35
1.44
2.1
1.8
—
—
—
0
0
71
556
1.36
1.43
5.4
2.9
0.23
0.51
e6/l
1.33
57
404
89
722
1.33
1.43
2.3
3.9
2.35
2.37
mmol/l
0.77
74
636
7
29
2.45
1.40
1.4
1.2
—
—
—
0
0
33
225
1.53
1.39
1.5
2.0
—
—
—
0
0
24
152
1.63
1.36
1.5
1.6
—
—
—
0
0
33
227
1.51
1.34
1.5
1.9
—
—
—
0
0
9
43
2.13
1.31
1.0
1.6
—
—
—
0
0
12
62
1.98
1.29
1.2
1.2
—
—
—
0
0
5
18
2.81
1.29
5.6
1.6
754.40
472.72
e6/l
—
5
18
9
44
2.08
1.28
2.3
1.5
—
—
—
0
0
8
35
2.32
1.28
1.0
1.1
—
—
—
0
0
12
63
1.94
1.24
1.1
1.0
—
—
—
0
0
33
231
1.48
1.24
11.5
7.1
106.09
104.49
mmol/l
1.02
33
231
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
10
49
2.08
1.23
3.4
2.8
0.37
0.39
u/ml
—
10
31
5
20
2.52
1.15
3.8
2.3
—
—
—
0
0
17
105
1.66
1.08
3.8
3.7
25.38
25.11
mmol/l
0.13
17
105
54
427
1.32
1.03
5.0
4.4
2.33
2.15
ug/l
0.12
48
386
240
2270
1.31
1.01
4.6
3.9
4.52
4.73
mmol/l
2.78
224
2106
101
869
1.25
1.00
5.6
3.2
—
—
—
0
0
48
376
1.33
0.98
3.6
3.7
193.44
419.44
ng/l
0.64
31
277
9
50
1.82
0.97
2.4
1.2
—
4.86
—
0
9
10
55
1.85
0.93
3.8
4.1
21.89
24.81
mmol/l
—
10
55
10
170
0.57
0.93
1.5
1.6
—
—
—
0
0
26
188
1.42
0.86
3.1
2.9
—
—
—
0
0
70
587
1.25
0.86
7.0
3.3
0.00
0.01
estimate
0.50
34
193
10
57
1.78
0.84
2.6
1.7
—
—
—
0
0
41
325
1.30
0.79
3.4
2.5
1.50
1.00
e6/l
0.17
23
173
69
584
1.24
0.79
1.5
1.6
1.41
1.35
mmol/l
0.18
64
484
6
34
1.78
0.76
8.8
3.6
59.33
54.12
%
—
6
34
28
211
1.36
0.75
2.9
9.4
-0.52
1.49
mmol/l
1.60
17
167
7
38
1.86
0.74
2.9
1.2
—
1.04
—
0
5
7
39
1.81
0.73
1.0
1.6
—
—
—
0
0
226
2151
1.22
0.71
4.0
3.6
1.32
1.24
mmol/l
0.84
209
1979
5
26
1.94
0.71
1.0
1.5
—
—
—
0
0
32
251
1.31
0.67
6.0
6.3
—
—
—
0
0
12
78
1.56
0.66
1.8
1.9
—
—
—
0
0
5
29
1.74
0.64
1.0
1.7
—
—
—
0
0
235
2254
1.21
0.63
4.5
3.9
1.44
1.50
mmol/l
1.83
218
2079
5
30
1.68
0.61
3.4
1.2
—
—
—
0
0
240
2309
1.21
0.61
4.9
4.3
2.68
2.81
mmol/l
1.60
223
2125
0
21
0.00
0.60
0.0
1.8
—
—
—
0
0
0
21
0.00
0.60
0.0
1.8
—
—
—
0
0
0
21
0.00
0.60
0.0
1.8
—
—
—
0
0
11
72
1.55
0.60
1.9
1.8
—
—
—
0
0
19
142
1.36
0.56
1.2
3.2
67.25
67.02
g/l
0.06
19
129
6
37
1.63
0.56
1.3
1.0
—
—
—
0
0
6
39
1.55
0.53
1.0
1.2
—
20.43
—
0
7
6
40
1.51
0.52
5.2
2.2
131.83
132.97
g/l
—
6
29
15
110
1.38
0.50
1.5
1.5
—
—
—
0
0
11
150
0.72
0.42
1.4
1.3
—
—
—
0
0
174
1657
1.12
0.41
3.2
3.2
—
—
—
0
0
5
33
1.52
0.41
1.0
1.1
—
—
—
0
0
0
16
0.00
0.41
0.0
1.0
—
38.75
—
0
8
0
16
0.00
0.41
0.0
1.0
—
546.78
—
0
9
5
34
1.48
0.40
1.0
1.0
—
2.34
—
0
18
5
34
1.48
0.40
1.2
1.6
—
—
—
0
0
31
261
1.21
0.40
2.7
2.5
0.75
0.78
ug/l
0.05
17
158
7
105
0.66
0.40
1.7
1.6
—
—
—
0
0
17
214
0.78
0.39
1.8
1.7
—
—
—
0
0
57
508
1.15
0.39
1.6
1.6
—
—
—
0
0
6
41
1.47
0.36
4.3
3.7
7.13
5.65
umol/l
—
6
32
6
90
0.66
0.33
2.3
3.6
5.67
1602.75
u/ml
—
6
80
8
63
1.28
0.28
1.1
1.6
2.59
2.87
g/l
—
8
56
21
242
0.86
0.23
1.8
1.7
—
—
—
0
0
7
93
0.75
0.23
1.4
1.5
—
—
—
0
0
0
10
0.00
0.21
0.0
1.7
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
0
10
0.00
0.21
0.0
1.7
—
—
—
0
0
6
48
1.26
0.20
1.0
1.4
—
—
—
0
0
6
48
1.26
0.20
1.0
1.4
—
—
—
0
0
6
49
1.23
0.20
1.2
1.5
0.00
0.00
g/l
—
6
42
6
50
1.20
0.20
1.0
1.7
—
—
—
0
0
6
50
1.20
0.20
1.2
1.5
0.00
0.00
g/l
—
6
42
39
357
1.11
0.19
3.6
4.3
19.94
20.53
%
0.10
18
162
6
53
1.13
0.19
1.2
1.5
0.00
0.00
g/l
—
6
45
7
58
1.21
0.18
1.1
1.6
0.00
1.61
g/l
—
7
49
7
61
1.15
0.17
2.3
1.2
1.19
1.24
g/l
—
7
55
40
370
1.09
0.17
2.0
2.2
—
—
—
0
0
8
68
1.18
0.16
1.1
1.6
7.75
7.21
g/l
—
8
61
8
68
1.18
0.16
1.1
1.6
—
—
—
0
0
8
68
1.18
0.16
1.1
1.6
3.66
3.39
g/l
—
8
61
8
70
1.15
0.16
1.1
1.4
—
—
—
0
0
8
73
1.10
0.16
1.4
1.8
—
—
—
0
0
36
389
0.92
0.16
2.3
3.3
2.44
2.45
mmol/l
0.37
30
338
6
76
0.79
0.16
2.2
1.7
—
—
—
0
0
36
334
1.09
0.14
1.9
2.0
—
—
—
0
0
13
114
1.15
0.12
1.8
1.7
293.46
336.85
mu/l
0.44
13
108
44
465
0.94
0.12
1.7
1.4
—
—
—
0
0
6
54
1.11
0.09
1.0
1.7
—
—
—
0
0
6
55
1.09
0.09
1.2
1.4
40.00
38.19
g/l
—
6
48
7
64
1.10
0.08
1.1
1.6
9.91
10.20
g/l
—
7
57
7
83
0.84
0.07
1.7
1.5
—
—
—
0
0
15
163
0.92
0.07
1.3
1.6
—
—
—
0
0
12
114
1.05
0.01
3.3
8.8
93.17
94.21
%
0.19
12
114
15
156
0.96
0.00
1.0
1.0
—
—
—
0
0
13
132
0.98
0.00
1.8
1.4
—
—
—
0
0
11
115
0.95
0.00
3.5
8.7
1.35
1.46
%
0.19
11
115
12
116
1.04
0.00
3.3
8.6
0.60
0.70
%
0.59
12
116
17
174
0.98
0.00
1.2
1.2
42.83
138.09
iu/ml
—
6
64
0
9
0.00
0.00
0.0
1.2
—
117.37
—
0
9
6
59
1.02
0.00
2.0
1.2
0.22
0.24
g/l
—
6
54
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
0.00
0.0
1.2
—
—
—
0
0
8
82
0.97
-0.00
1.4
1.5
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
58.80
—
0
5
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
19.38
—
0
5
6
60
1.00
-0.00
1.2
1.6
—
—
—
0
0
0
5
0.00
-0.00
0.0
5.2
—
1.23
—
0
5
11
110
1.00
-0.00
1.5
1.5
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
8
83
0.96
-0.00
1.4
1.5
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
6
60
1.00
-0.00
1.2
1.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
9
90
1.00
-0.00
2.2
1.6
—
—
—
0
0
8
83
0.96
-0.00
1.4
1.5
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
8
82
0.97
-0.00
1.4
1.5
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
21.08
—
0
6
0
5
0.00
-0.00
0.0
1.0
—
1.86
—
0
5
Mortality – FinRegistry
↥Association
Association between endpoint M13_VALGUS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_VALGUS | 0.979 [0.79, 1.21] | 0.846 |
| Birth year | 0.994 [0.99, 1.0] | 0.186 |
During the follow-up period (1.1.1998 — 31.12.2019), 113 out of 1234 females with M13_VALGUS died.
Males
No dataMortality risk
Mortality risk for people of age
years, who have M13_VALGUS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.108% | No data |
| 5 | 0.609% | No data |
| 10 | 1.436% | No data |
| 15 | 2.867% | No data |
| 20 | 4.812% | No data |
Relationships between endpoints
↥Index endpoint: M13_VALGUS – Valgus deformity, not elsewhere classified
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data