No definition available.
Disorders of male genital organs in diseases classified elsewhere
EFO MESH Endpoint Browser PheWeb
N14_MALEGENINOTH
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleonly males |
226837 |
2. Check conditionsNone |
226837 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
225 |
4. Check minimum number of eventsNone |
225 |
5. Include endpointsNone |
225 |
6. Filter based on genotype QC (FinnGen only) |
225 |
Control definitions (FinnGen only)
- Control exclude
- N14_MALEGEN
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
Similar endpoints
↥List of similar endpoints to
Disorders of male genital organs in diseases classified elsewhere
based on the number of shared cases.
Similar with more cases:
- Diseases of male genital organs
- Genitourinary diseases
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 2125 | - | 2125 |
| Only index persons | 2038 | - | 2038 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.06 | - | 0.06 |
| Only index persons | 0.08 | - | 0.08 |
| Median age at first event (years) | |||
| Whole population | - | - | 34.45 |
| Only index persons | - | - | 34.35 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 225 | - | 225 |
| Unadjusted period prevalence (%) | 0.10 | - | 0.10 |
| Median age at first event (years) | 46.54 | - | 46.54 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 201
- Matched controls
- 2009
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
N51.8*A60.0
ICD-10 Finland
Herpes simplex infection of the genitals in men
714.2
90.9
83
*
N51.2*B37.4
ICD-10 Finland
Candidal balanitis
+∞
44.4
41
*
N51.2
ICD-10 Finland
Balanitis in diseases classified elsewhere
+∞
29.9
28
*
N51.8
ICD-10 Finland
Other disorders of male genital organs in diseases classified elsewhere
+∞
24.5
23
*
J05AB11
ATC
valaciclovir; oral
8.2
24.1
58
94
Z11.3
ICD-10 Finland
Special screening examination for infections with a predominantly sexual mode of transmission
9.3
21.2
46
62
J05AB01
ATC
aciclovir; systemic
5.8
20.4
65
152
N45.9
ICD-10 Finland
Orchitis, epididymitis and epididymo-orchitis without abscess
81.6
20.1
22
*
N48.1
ICD-10 Finland
Balanoposthitis
16.6
18.8
30
21
D01AC20
ATC
imidazoles/triazoles in combination with corticosteroids; topical
4.0
15.1
71
240
J02AC01
ATC
fluconazole; systemic
3.8
12.3
58
192
A60.0
ICD-10 Finland
Herpesviral infection of genitalia and urogenital tract
23.0
12.2
17
8
N40
ICD-10 Finland
Hyperplasia of prostate
4.6
12.2
45
119
KC1EE
NOMESCO Finland
Ultrasound measurement of residual urine
5.4
11.3
35
76
N51.1
ICD-10 Finland
Disorders of testis and epididymis in diseases classified elsewhere
115.8
10.5
11
*
N47
ICD-10 Finland
Redundant prepuce, phimosis and paraphimosis
34.5
10.5
13
*
KE1BE
NOMESCO Finland
Rectal ultrasound examinaiton of prostata
6.6
10.2
26
44
N41.1
ICD-10 Finland
Chronic prostatitis
15.7
10.2
16
11
KGH10
NOMESCO Finland
Operation for phimosis
42.3
10.1
12
*
J01MA02
ATC
ciprofloxacin; systemic
2.7
9.5
86
437
J01MA01
ATC
ofloxacin; systemic
5.5
8.4
24
48
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
2.4
8.3
103
606
G04CA01
ATC
alfuzosin; oral
3.4
8.3
41
139
N02AX02
ATC
tramadol; systemic, rectal
2.3
7.6
93
539
N48.8
ICD-10 Finland
Other specified disorders of penis
83.0
7.5
8
*
KF8AE
NOMESCO Finland
Ultrasound examination of scrotum
12.7
7.2
12
10
L30.9
ICD-10 Finland
Dermatitis, unspecified
3.1
7.1
40
149
R10.3
ICD-10 Finland
Pain localized to other parts of lower abdomen
3.4
6.9
33
109
XKD00
NOMESCO Finland
Uroflowmetry
3.4
6.9
33
109
A56.0
ICD-10 Finland
Chlamydial infection of lower genitourinary tract
9.2
6.7
13
15
J01DA01
ATC
[U] cefalexin; systemic
2.1
6.3
122
843
A18.1
ICD-10 Finland
Tuberculosis of genitourinary system
+∞
6.3
6
*
KGB00
NOMESCO Finland
Biopsy of penis
+∞
6.3
6
*
KFC00
NOMESCO Finland
Unilateral orchiectomy
27.6
6.3
8
*
N03AF01
ATC
carbamazepine; oral, rectal
4.7
6.2
20
46
UKC02
NOMESCO Finland
Cystoscopy
3.3
6.1
30
102
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
63
173
4.67
21.83
2.2
2.3
—
—
—
0
0
66
193
4.42
21.03
2.2
2.3
—
—
—
0
0
18
15
12.96
18.02
1.2
1.3
—
—
—
0
0
46
166
3.23
10.25
4.5
3.8
30.3
28.3
%
0.49
30
116
10
10
10.42
8.70
1.1
1.0
—
—
—
0
0
172
1262
2.54
8.25
9.2
8.1
73.9
79.2
u/l
0.68
166
1201
161
1149
2.41
8.18
5.2
3.7
9.7
11.2
mm/h
0.51
149
1065
209
1720
4.03
7.64
17.2
13.1
20.8
26.0
mg/l
1.47
175
1358
108
669
2.18
7.55
7.3
5.2
37.1
36.3
g/l
0.63
102
629
126
836
2.15
7.32
6.5
7.1
10.8
12.6
umol/l
2.45
121
810
112
728
2.07
6.67
9.9
8.6
1.2
1.2
mmol/l
0.41
100
629
101
657
1.97
5.78
8.8
7.9
1.2
1.2
mmol/l
0.15
92
609
9
8
11.65
5.34
1.2
1.1
1.7
1.7
mmol/l
—
9
8
18
54
3.54
5.29
1.7
2.8
—
—
—
0
0
20
65
3.28
5.21
4.2
3.3
—
—
—
0
0
99
672
1.85
4.75
4.4
3.9
—
—
—
0
0
95
642
1.83
4.58
4.3
3.3
29.2
58.4
ng/l
1.62
66
434
16
50
3.37
4.43
1.6
2.6
—
—
—
0
0
51
284
2.03
4.38
2.3
2.2
13.5
14.5
nmol/l
0.38
42
259
127
952
1.77
4.21
6.6
6.0
7.0
6.9
mmol/l
0.16
122
911
77
509
1.78
3.88
2.4
2.2
70.6
72.8
nmol/l
0.26
65
464
170
1409
1.84
3.80
4.7
3.5
1.8
2.0
mu/l
0.97
155
1296
137
1068
1.72
3.79
5.6
3.8
8.9
1.7
ug/l
0.58
126
960
54
324
1.88
3.70
3.1
3.8
1859.7
838.5
ng/l
0.26
42
262
78
529
1.73
3.54
3.5
3.0
—
—
—
0
0
6
6
10.23
3.51
1.0
1.0
—
—
—
0
0
11
32
3.56
3.38
1.4
1.2
—
—
—
0
0
200
1772
2.16
3.36
19.8
15.6
4.0
4.0
mmol/l
0.01
195
1728
73
499
1.69
3.17
4.3
2.9
57.0
56.2
u/l
0.10
68
473
57
364
1.76
3.16
2.4
2.6
—
—
—
0
0
66
440
1.71
3.14
4.9
3.6
2.3
2.3
mmol/l
0.14
57
396
121
944
1.61
3.08
10.4
10.3
4.0
4.1
e9/l
0.33
112
829
211
1926
2.54
3.02
13.1
9.6
31.2
33.6
u/l
1.23
206
1877
97
723
1.60
2.96
2.8
2.7
0.0
0.0
estimate
0.00
11
104
46
282
1.79
2.91
1.5
1.4
—
—
—
0
0
5
6
8.48
2.76
1.6
1.0
—
—
—
0
0
5
6
8.48
2.76
1.6
1.0
—
—
—
0
0
5
6
8.48
2.76
1.6
1.0
—
—
—
0
0
51
330
1.71
2.67
1.9
1.9
0.8
1.3
mg/l
1.58
38
246
95
718
1.56
2.66
3.8
3.8
0.0
0.0
estimate
—
10
110
5
7
7.27
2.56
1.4
1.1
—
—
—
0
0
13
51
2.64
2.49
2.1
1.6
—
—
—
0
0
93
709
1.53
2.47
2.8
2.7
0.0
0.0
estimate
0.00
11
104
61
425
1.60
2.39
3.4
3.4
1451.7
1246.4
ng/l
0.12
52
358
77
567
1.54
2.37
2.1
1.8
94.3
89.9
pmol/l
0.34
34
336
28
157
1.89
2.35
3.9
3.8
1.3
1.5
mmol/l
0.13
21
127
33
196
1.80
2.32
1.4
1.2
1.6
8.7
u/ml
—
9
82
40
255
1.69
2.21
1.7
1.9
—
—
—
0
0
138
1161
1.49
2.18
3.4
2.9
—
—
—
0
0
28
162
1.83
2.14
5.1
7.2
—
—
—
0
0
5
10
5.08
2.08
1.0
1.2
—
—
—
0
0
6
15
4.08
2.05
1.2
1.1
—
—
—
0
0
130
1090
1.46
2.03
3.6
2.9
14.9
14.8
pmol/l
0.24
118
995
5
11
4.62
1.95
1.4
2.2
901.6
854.9
u/ml
—
5
11
6
16
3.82
1.95
1.2
1.1
—
—
—
0
0
31
192
1.71
1.90
19.7
22.2
1.5
1.2
inr
—
6
20
82
637
1.45
1.89
4.8
3.9
30.5
38.6
u/l
1.86
76
601
5
12
4.23
1.83
1.2
1.0
—
—
—
0
0
179
1618
1.52
1.75
7.0
5.4
41.2
39.9
mmol/mol
0.95
159
1527
61
454
1.47
1.73
3.0
2.5
335.1
8558.8
umol/l
2.08
52
406
5
13
3.91
1.72
1.0
1.1
—
—
—
0
0
26
159
1.72
1.68
11.4
9.2
9.6
10.0
mmol/l
0.11
26
151
6
19
3.21
1.67
1.2
1.5
—
—
—
0
0
6
19
3.21
1.67
1.2
1.5
—
—
—
0
0
6
19
3.21
1.67
1.2
1.5
—
—
—
0
0
6
19
3.21
1.67
1.2
1.5
—
—
—
0
0
34
224
1.61
1.67
1.8
1.6
960.6
999.1
nmol/l
0.11
22
177
12
56
2.21
1.64
2.1
1.9
—
—
—
0
0
102
841
1.39
1.64
5.0
3.4
19.3
22.5
%
1.34
47
318
72
560
1.42
1.61
3.0
2.7
—
—
—
0
0
6
20
3.05
1.59
1.2
1.5
—
—
—
0
0
6
20
3.05
1.59
1.2
1.5
—
—
—
0
0
181
1651
1.49
1.58
13.1
11.9
86.1
85.7
ml/min/173m2
0.08
152
1369
71
554
1.41
1.56
3.0
2.4
214.5
220.8
ug/l
0.04
63
516
7
27
2.64
1.52
1.6
1.1
—
—
—
0
0
32
213
1.59
1.51
1.4
1.2
9.9
41.0
iu/ml
—
8
67
43
309
1.48
1.45
1.3
1.2
0.9
1.2
u/ml
0.52
11
83
5
16
3.17
1.44
2.0
1.8
—
—
—
0
0
29
192
1.59
1.41
10.2
13.4
1.9
0.9
mmol/l
1.44
23
147
9
41
2.24
1.38
3.0
2.0
—
—
—
0
0
151
1349
1.36
1.37
4.6
3.1
43.1
54.9
u/l
2.67
144
1293
9
42
2.19
1.35
1.3
1.4
—
—
—
0
0
9
42
2.19
1.35
1.4
1.1
—
—
—
0
0
15
84
1.84
1.30
1.8
2.2
39.9
39.6
u/l
0.01
15
73
5
19
2.67
1.22
1.2
1.8
—
—
—
0
0
19
119
1.65
1.16
1.8
1.5
—
—
—
0
0
12
65
1.89
1.16
2.2
1.5
0.1
0.1
iu/ml
—
5
14
5
20
2.53
1.15
1.2
1.1
—
—
—
0
0
5
20
2.53
1.15
1.2
1.8
—
—
—
0
0
34
246
1.45
1.12
2.7
2.7
0.3
0.4
e6/l
0.22
19
130
194
1827
1.45
1.11
5.3
4.5
2.8
2.8
mmol/l
0.10
176
1711
12
66
1.86
1.11
2.6
2.1
0.5
1.3
ug/l
0.47
12
57
5
21
2.41
1.09
1.2
1.4
—
—
—
0
0
191
1798
1.41
1.05
4.8
4.1
4.7
4.6
mmol/l
0.41
176
1694
9
46
2.00
1.05
1.1
1.0
—
7.2
—
0
5
7
34
2.09
1.04
1.0
1.2
—
—
—
0
0
23
156
1.53
1.03
9.9
10.3
1.3
1.4
mmol/l
0.15
23
148
37
277
1.40
1.02
1.7
1.7
267742307.7
392.5
pmol/l
0.49
31
242
45
349
1.36
1.01
3.5
2.8
0.0
0.0
estimate
0.50
11
97
190
1793
1.38
0.97
4.8
4.1
1.3
1.3
mmol/l
0.25
171
1675
16
101
1.63
0.96
1.4
1.7
—
—
—
0
0
6
27
2.25
0.94
1.0
1.2
—
—
—
0
0
52
418
1.32
0.93
1.7
1.6
1.6
1.5
mmol/l
0.21
46
354
34
256
1.39
0.92
2.6
2.5
0.6
0.7
e6/l
0.13
20
139
42
328
1.34
0.91
2.2
2.0
2.8
3.1
mg/l
0.34
31
286
12
72
1.70
0.87
1.3
1.5
1.4
1.6
g/l
0.47
12
64
21
147
1.47
0.84
2.1
2.4
10.7
11.2
ug/l
0.03
15
136
182
1721
1.30
0.80
17.7
14.0
41.5
42.1
%
0.32
129
1350
25
186
1.39
0.74
1.6
1.9
—
—
—
0
0
49
404
1.27
0.73
3.0
2.8
0.1
0.4
e6/l
2.34
36
293
5
26
1.94
0.71
1.0
1.0
—
—
—
0
0
7
41
1.73
0.70
1.4
1.5
—
—
—
0
0
11
69
1.62
0.69
1.1
1.3
365.6
88.1
iu/ml
—
5
27
183
1741
1.27
0.69
4.3
3.8
1.5
1.4
mmol/l
1.13
167
1632
7
42
1.69
0.69
1.9
1.2
—
—
—
0
0
7
42
1.69
0.69
1.6
1.7
—
—
—
0
0
17
121
1.44
0.64
4.3
2.5
77.3
69.0
ml/min/173m2
—
7
47
177
1683
1.24
0.64
5.2
4.1
6.2
6.1
mmol/l
0.52
156
1553
14
97
1.47
0.60
1.6
1.6
—
—
—
0
0
24
185
1.33
0.59
1.6
1.8
—
—
—
0
0
6
40
1.51
0.52
4.2
5.0
23.7
40.2
mg/l
—
6
35
69
613
1.18
0.51
3.1
2.4
0.6
0.7
ug/l
1.25
45
342
29
237
1.26
0.48
3.9
3.2
2.4
2.4
mmol/l
0.04
24
209
7
50
1.41
0.45
4.0
3.6
—
—
—
0
0
5
31
1.63
0.43
1.4
1.2
—
—
—
0
0
5
31
1.63
0.43
1.4
1.2
—
—
—
0
0
5
33
1.53
0.41
1.2
1.3
—
—
—
0
0
11
79
1.41
0.41
1.0
1.0
—
—
—
0
0
0
17
0.00
0.41
0.0
2.5
—
—
—
0
0
6
41
1.48
0.36
1.0
1.1
—
—
—
0
0
6
42
1.44
0.36
1.3
1.1
—
—
—
0
0
37
322
1.18
0.35
1.6
1.5
18.2
18.5
nmol/l
0.04
31
283
6
44
1.37
0.34
1.2
1.8
—
—
—
0
0
6
46
1.31
0.33
1.2
1.1
—
—
—
0
0
11
83
1.34
0.32
1.3
1.4
—
—
—
0
0
12
92
1.32
0.32
15.8
16.1
25.6
24.4
mmol/l
0.91
12
83
12
93
1.31
0.30
15.1
12.0
26.5
24.6
mmol/l
1.10
12
93
17
205
0.82
0.29
1.8
1.7
—
—
—
0
0
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
0
12
0.00
0.21
0.0
2.1
—
—
—
0
0
0
14
0.00
0.20
0.0
1.2
—
—
—
0
0
0
14
0.00
0.20
0.0
1.2
—
—
—
0
0
0
14
0.00
0.20
0.0
1.2
—
—
—
0
0
0
14
0.00
0.20
0.0
1.2
—
—
—
0
0
0
14
0.00
0.20
0.0
1.2
—
—
—
0
0
8
69
1.17
0.16
1.9
1.2
—
—
—
0
0
30
280
1.08
0.11
2.4
2.5
30.2
30.3
s
0.04
30
272
5
44
1.14
0.10
1.2
1.8
—
—
—
0
0
5
46
1.09
0.09
2.6
1.7
—
—
—
0
0
23
215
1.08
0.08
3.5
2.4
28.3
24.2
%
0.38
18
196
15
160
0.93
0.04
3.3
2.8
—
—
—
0
0
10
96
1.04
0.00
1.2
1.5
—
—
—
0
0
0
8
0.00
0.00
0.0
2.0
—
58.8
—
0
8
0
5
0.00
0.00
0.0
2.6
—
110.3
—
0
5
0
6
0.00
0.00
0.0
4.5
—
—
—
0
0
5
53
0.94
0.00
1.6
1.2
—
—
—
0
0
0
6
0.00
0.00
0.0
4.5
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint N14_MALEGENINOTH and mortality.
Females
No dataMales
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| N14_MALEGENINOTH | 1.305 [1.07, 1.59] | 0.008 |
| Birth year | 0.987 [0.98, 1.0] | 0.007 |
During the follow-up period (1.1.1998 — 31.12.2019), 156 out of 1765 males with N14_MALEGENINOTH died.
Mortality risk
Mortality risk for people of age
years, who have N14_MALEGENINOTH.| N-year risk | Females | Males |
|---|---|---|
| 1 | No data | 0.236% |
| 5 | No data | 1.558% |
| 10 | No data | 3.758% |
| 15 | No data | 7.027% |
| 20 | No data | 11.796% |
Relationships between endpoints
↥Index endpoint: N14_MALEGENINOTH – Disorders of male genital organs in diseases classified elsewhere
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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