No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
221 |
4. Check minimum number of eventsNone |
221 |
5. Include endpointsNone |
221 |
6. Filter based on genotype QC (FinnGen only) |
221 |
Control definitions (FinnGen only)
- Control exclude
- N14_UROLITHIASIS
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- N20-N23
- Name in latin
- Colica renalis non specificata
Similar endpoints
↥List of similar endpoints to
Unspecified renal colic
based on the number of shared cases.
Similar with more cases:
- Urolithiasis
- Genitourinary diseases
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1579 | 646 | 917 |
| Only index persons | 1527 | 638 | 889 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.02 | 0.02 | 0.03 |
| Only index persons | 0.03 | 0.02 | 0.03 |
| Median age at first event (years) | |||
| Whole population | 51.25 | 48.54 | 53.44 |
| Only index persons | 51.02 | 48.38 | 52.91 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 221 | 105 | 116 |
| Unadjusted period prevalence (%) | 0.04 | 0.04 | 0.05 |
| Median age at first event (years) | 53.52 | 50.95 | 55.85 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 202
- Matched controls
- 2020
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
N23
ICD-10 Finland
Unspecified renal colic
+∞
289.1
201
*
N20.1
ICD-10 Finland
Calculus of ureter
667.9
87.1
80
*
KH1AD
NOMESCO Finland
CT of urinary organs
84.5
62.5
68
12
N20.9
ICD-10 Finland
Urinary calculus, unspecified
271.3
43.8
43
*
N20.0
ICD-10 Finland
Calculus of kidney
232.5
38.2
38
*
KH1AA
NOMESCO Finland
Urinary tract X-ray examination without contrast
148.3
25.2
26
*
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
4.4
21.4
109
423
KBV02
NOMESCO Finland
Cystoscopic insertion of stent into ureter
47.3
21.0
25
6
KAT00
NOMESCO Finland
Extracorporeal shock wave lithotripsy of pelvis of kidney
+∞
19.1
18
*
KBE12
NOMESCO Finland
Transluminal endoscopic extraction of calculus of ureter
+∞
19.1
18
*
UKB02
NOMESCO Finland
Retrograde ureteroscopy
184.6
16.8
17
*
KH1AE
NOMESCO Finland
Urinary tract ultrasound examination
8.7
15.5
34
46
N20.2
ICD-10 Finland
Calculus of kidney with calculus of ureter
+∞
13.7
13
*
KBV12
NOMESCO Finland
Transluminal endoscopic removal of stent from ureter
34.5
12.8
16
5
UKC02
NOMESCO Finland
Cystoscopy
3.8
11.7
54
175
N02BE01
ATC
paracetamol; systemic, rectal
3.9
9.7
183
1441
5921A
ICD-9 Finland
Calculus of kidney and ureter, Calculus of ureter
+∞
9.4
9
*
M54.9
ICD-10 Finland
Dorsalgia, unspecified
4.2
9.3
36
99
N39.0
ICD-10 Finland
Urinary tract infection, site not specified
3.8
9.0
39
119
R10.3
ICD-10 Finland
Pain localized to other parts of lower abdomen
3.0
8.8
58
240
R31
ICD-10 Finland
Unspecified haematuria
4.4
8.6
31
79
N21.0
ICD-10 Finland
Calculus in bladder
+∞
8.4
8
*
KAE12
NOMESCO Finland
Retrograde ureteronephroscopic lithotripsy in pelvis of kidney
+∞
8.4
8
*
U95
ICPC
Urinary calculus
+∞
8.4
8
*
N13.3
ICD-10 Finland
Other and unspecified hydronephrosis
18.1
8.2
12
7
G04CA02
ATC
tamsulosin; oral
2.7
7.9
61
275
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
3.7
7.6
33
100
A02BC02
ATC
pantoprazole; systemic
2.4
7.6
139
977
UKA02
NOMESCO Finland
Retrograde ureteronephroscopy
+∞
7.3
7
*
R51.80
ICD-10 Finland
Headache
3.0
6.6
38
143
N02AX02
ATC
tramadol; systemic, rectal
2.2
6.3
94
580
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
112
622
2.62
11.22
4.3
3.4
—
—
—
0
0
93
500
2.48
9.64
4.4
3.2
0.4
0.6
e6/l
0.47
75
370
162
1135
2.60
9.15
7.0
4.2
3968.2
218.6
e6/l
—
5
19
61
282
2.61
8.55
2.9
2.6
1.5
0.9
e6/l
0.61
33
155
58
268
2.58
8.10
3.0
2.9
2.1
2.2
e6/l
0.03
30
140
82
462
2.23
7.24
2.7
2.7
331.7
6221.2
umol/l
1.95
71
409
62
328
2.24
6.26
5.0
3.3
570.4
221.2
ng/l
0.37
46
244
126
877
2.02
6.06
4.7
3.5
0.0
0.0
estimate
0.00
26
161
125
869
2.01
6.02
6.2
4.8
0.0
0.0
estimate
0.00
28
169
124
862
2.00
5.94
4.7
3.5
0.0
0.0
estimate
0.00
27
171
117
830
1.87
4.96
9.3
6.4
1.2
1.2
mmol/l
0.11
107
699
88
574
1.89
4.83
2.9
3.3
2.3
2.3
mmol/l
0.01
81
512
108
756
1.84
4.70
8.6
5.3
1.2
1.2
mmol/l
0.50
103
682
25
100
2.69
4.57
5.0
5.5
25.5
24.7
mmol/l
0.52
25
100
210
1864
3.54
4.53
21.4
15.0
139.8
139.6
mmol/l
0.33
205
1809
210
1871
3.46
4.35
21.5
15.1
4.0
4.0
mmol/l
0.02
204
1815
213
1944
3.64
4.34
21.1
15.6
85.2
77.9
umol/l
1.18
213
1944
169
1387
1.93
4.15
8.7
7.4
83.5
79.0
u/l
0.28
162
1302
115
846
1.75
4.05
3.8
4.2
—
—
—
0
0
192
1656
2.21
3.99
4.7
4.4
1.8
1.9
mu/l
0.34
172
1526
135
1044
1.75
3.94
5.8
4.4
6.7
6.7
mmol/l
0.13
126
969
37
193
2.10
3.77
1.6
1.8
—
—
—
0
0
123
941
1.69
3.61
5.4
6.4
12.0
12.0
umol/l
0.01
116
899
164
1359
1.80
3.59
4.2
3.8
14.5
14.7
pmol/l
0.29
148
1233
82
565
1.72
3.53
3.0
2.5
61.9
55.0
u/l
1.25
73
528
196
1726
2.20
3.50
16.8
12.2
81.3
84.0
ml/min/173m2
0.97
179
1425
148
1200
1.71
3.40
3.2
3.2
—
—
—
0
0
65
424
1.76
3.38
2.2
2.2
—
—
—
0
0
39
216
1.98
3.38
2.0
3.3
5.1
11.9
umol/l
1.95
34
194
100
738
1.65
3.27
4.8
4.9
36.0
35.8
g/l
0.14
92
695
36
197
1.99
3.22
1.6
1.9
—
—
—
0
0
202
1815
2.31
3.18
20.5
13.5
19.8
23.1
mg/l
0.90
166
1416
95
697
1.64
3.15
5.0
3.6
—
—
—
0
0
61
399
1.73
3.12
2.0
1.6
1.1
1.1
mg/l
0.01
44
310
161
1352
1.70
3.08
5.3
3.9
12.2
11.4
mm/h
0.25
145
1235
129
1030
1.61
2.97
8.5
9.0
4.1
4.2
e9/l
0.34
113
895
86
625
1.62
2.92
2.8
3.3
28.2
30.6
u/l
0.44
78
594
34
190
1.93
2.87
8.2
6.7
1.4
1.0
mmol/l
0.24
27
146
19
84
2.38
2.86
1.7
1.6
—
—
—
0
0
33
184
1.93
2.80
2.8
3.5
—
—
—
0
0
68
470
1.65
2.80
5.6
3.7
0.0
0.0
estimate
0.00
27
165
190
1690
1.89
2.76
21.2
13.5
40.9
40.3
%
0.41
139
1276
30
163
1.97
2.74
8.9
7.0
124.9
121.0
g/l
0.55
30
155
91
680
1.57
2.70
4.3
3.5
27.5
41.1
ng/l
0.88
52
458
68
476
1.62
2.65
3.0
2.9
2366.6
1411.5
ng/l
0.53
56
403
9
26
3.56
2.51
1.1
1.1
—
—
—
0
0
44
282
1.70
2.39
1.7
1.9
—
—
—
0
0
5
8
6.36
2.38
1.2
1.1
—
—
—
0
0
149
1276
1.51
2.18
3.7
3.3
44.5
47.9
u/l
0.19
135
1207
66
485
1.51
2.03
1.8
1.6
1.3
1.4
mmol/l
0.63
54
405
5
11
4.62
1.95
1.2
1.8
—
—
—
0
0
9
34
2.72
1.88
1.6
1.2
—
—
—
0
0
9
34
2.72
1.88
1.6
1.2
—
—
—
0
0
6
17
3.60
1.85
5.3
2.8
3.2
3.9
nmol/l
—
6
17
191
1752
1.66
1.84
4.8
4.3
6.1
5.9
mmol/l
0.63
177
1613
184
1673
1.60
1.83
6.2
5.5
41.4
39.8
mmol/mol
1.23
174
1577
19
103
1.92
1.78
7.5
7.4
0.7
0.7
%
0.14
19
103
19
104
1.90
1.73
7.4
7.0
1.3
1.5
%
0.25
19
104
85
678
1.41
1.67
2.0
1.9
93.7
95.3
pmol/l
0.16
53
347
42
292
1.54
1.65
1.5
1.3
3.9
7.9
u/ml
0.57
16
113
17
92
1.92
1.61
1.1
1.0
—
—
—
0
0
6
20
3.05
1.59
1.0
1.3
—
—
—
0
0
46
334
1.48
1.48
1.6
1.5
—
—
—
0
0
19
111
1.78
1.44
2.3
3.2
1.3
1.4
mmol/l
0.02
14
77
42
301
1.49
1.44
1.4
1.3
15.4
32.9
iu/ml
—
8
97
55
419
1.42
1.37
1.2
1.3
0.6
0.8
u/ml
0.36
11
110
10
48
2.13
1.30
3.2
2.6
23.4
23.3
mmol/l
—
10
39
39
282
1.47
1.28
2.0
1.7
31.2
29.2
s
1.06
39
273
8
40
2.04
1.13
1.1
1.5
—
—
—
0
0
23
153
1.56
1.11
4.4
3.7
1.8
2.1
mmol/l
0.14
17
118
8
41
1.99
1.10
3.8
1.6
—
—
—
0
0
19
121
1.62
1.09
1.7
1.5
—
—
—
0
0
17
105
1.67
1.09
1.2
1.3
200.6
169.1
u/ml
0.12
17
96
51
403
1.35
1.02
1.5
1.5
17.2
21.2
nmol/l
1.68
43
343
5
23
2.20
0.98
1.0
1.4
—
—
—
0
0
5
23
2.20
0.98
1.0
1.4
—
—
—
0
0
5
23
2.20
0.98
1.0
1.4
—
—
—
0
0
5
23
2.20
0.98
1.0
1.4
—
—
—
0
0
34
253
1.41
0.98
4.1
2.4
23.7
24.0
%
0.05
28
224
51
407
1.33
0.96
3.2
2.9
0.6
0.7
ug/l
1.47
30
265
192
1825
1.40
0.90
5.3
4.7
2.7
2.7
mmol/l
0.31
177
1688
8
43
1.89
0.88
1.1
1.5
—
—
—
0
0
188
1792
1.33
0.76
4.9
4.3
4.6
4.6
mmol/l
0.34
178
1667
5
24
2.11
0.75
1.4
1.2
—
—
—
0
0
5
24
2.11
0.75
1.0
1.4
—
—
—
0
0
5
24
2.11
0.75
1.0
1.4
—
—
—
0
0
51
422
1.27
0.74
2.9
2.0
3.3
3.1
mg/l
0.21
42
370
19
262
0.70
0.74
1.1
1.7
1.5
1.5
%
0.18
13
229
7
44
1.61
0.65
1.0
1.2
—
—
—
0
0
15
104
1.47
0.64
1.2
1.5
—
—
—
0
0
186
1781
1.28
0.64
4.8
4.3
1.4
1.4
mmol/l
1.38
172
1648
81
719
1.20
0.61
3.0
2.3
71.4
77.7
nmol/l
1.20
74
641
0
23
0.00
0.58
0.0
1.5
—
—
—
0
0
0
23
0.00
0.58
0.0
1.5
—
—
—
0
0
0
23
0.00
0.58
0.0
1.5
—
—
—
0
0
63
555
1.19
0.51
4.0
4.1
20.3
21.7
%
0.39
24
256
7
50
1.41
0.45
1.6
1.2
—
—
—
0
0
5
33
1.53
0.41
1.0
1.1
—
—
—
0
0
0
16
0.00
0.41
0.0
1.3
—
—
—
0
0
17
134
1.29
0.38
1.7
2.5
65.3
66.6
g/l
0.27
17
125
6
42
1.44
0.36
1.3
1.4
—
—
—
0
0
6
43
1.41
0.35
1.2
1.5
—
—
—
0
0
18
145
1.26
0.35
3.7
2.9
54.8
64.5
ml/min/173m2
—
10
66
18
146
1.25
0.33
2.0
2.5
14.7
7.7
ug/l
0.33
13
134
16
129
1.26
0.31
4.6
3.0
4.2
4.4
kpa
0.20
16
123
7
53
1.33
0.31
1.7
1.5
—
—
—
0
0
177
1721
1.14
0.30
4.3
3.9
1.4
1.3
mmol/l
1.68
162
1592
7
55
1.28
0.30
1.6
3.1
—
—
—
0
0
7
57
1.24
0.29
2.4
1.1
39.3
38.7
g/l
—
7
51
8
66
1.22
0.27
1.5
1.9
—
—
—
0
0
41
369
1.14
0.27
2.2
1.8
348.3
451.7
pmol/l
2.04
33
315
9
72
1.26
0.26
2.1
1.2
—
—
—
0
0
14
114
1.24
0.25
13.5
6.5
23.3
24.2
mmol/l
0.29
14
105
16
191
0.83
0.25
7.1
7.1
—
—
—
0
0
9
77
1.18
0.24
1.4
2.2
38.6
39.8
u/l
—
9
72
5
39
1.29
0.23
1.4
1.4
—
—
—
0
0
5
40
1.26
0.22
1.4
1.2
—
—
—
0
0
0
11
0.00
0.21
0.0
2.8
—
112.0
—
0
11
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
0
10
0.00
0.21
0.0
1.9
—
—
—
0
0
0
10
0.00
0.21
0.0
1.3
—
—
—
0
0
0
10
0.00
0.21
0.0
1.9
—
—
—
0
0
8
105
0.75
0.21
1.1
1.3
—
—
—
0
0
0
12
0.00
0.21
0.0
1.2
—
—
—
0
0
0
12
0.00
0.21
0.0
1.2
—
—
—
0
0
0
12
0.00
0.21
0.0
1.2
—
—
—
0
0
0
13
0.00
0.21
0.0
1.3
—
—
—
0
0
0
13
0.00
0.21
0.0
1.3
—
—
—
0
0
0
13
0.00
0.21
0.0
1.3
—
—
—
0
0
0
13
0.00
0.21
0.0
1.3
—
—
—
0
0
7
59
1.19
0.18
1.6
1.7
—
—
—
0
0
7
60
1.17
0.18
1.0
2.3
—
—
—
0
0
7
63
1.11
0.17
1.6
1.8
—
—
—
0
0
14
120
1.18
0.17
1.1
1.2
146.5
121.0
iu/ml
—
5
42
28
255
1.11
0.16
1.3
1.4
—
—
—
0
0
23
208
1.12
0.14
2.6
2.0
—
—
—
0
0
8
97
0.82
0.14
1.5
1.5
—
—
—
0
0
25
228
1.11
0.14
2.6
2.2
—
—
—
0
0
18
199
0.90
0.12
2.4
3.9
226.0
244.5
u/l
0.63
18
192
5
45
1.11
0.10
1.2
1.7
—
—
—
0
0
16
176
0.90
0.10
2.1
1.7
—
—
—
0
0
6
58
1.04
0.08
1.0
1.1
—
—
—
0
0
6
58
1.04
0.08
1.0
1.1
—
—
—
0
0
7
82
0.85
0.07
2.1
3.2
48.4
2218.2
u/ml
—
7
69
82
801
1.04
0.07
3.8
2.7
111.6
121.8
ug/l
0.27
77
747
32
308
1.05
0.04
2.5
1.6
1064.6
1254.3
nmol/l
0.61
27
245
11
114
0.96
0.00
2.5
1.7
—
—
—
0
0
0
9
0.00
0.00
0.0
1.3
—
—
—
0
0
0
9
0.00
0.00
0.0
1.4
—
—
—
0
0
0
9
0.00
0.00
0.0
1.2
—
—
—
0
0
0
9
0.00
0.00
0.0
1.2
—
—
—
0
0
0
9
0.00
0.00
0.0
1.7
—
—
—
0
0
0
9
0.00
0.00
0.0
2.1
—
46.2
—
0
9
6
59
1.02
0.00
1.2
1.6
—
—
—
0
0
0
9
0.00
0.00
0.0
1.1
—
—
—
0
0
0
9
0.00
0.00
0.0
2.0
—
—
—
0
0
5
50
1.00
0.00
1.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.5
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
8
0.00
0.00
0.0
8.5
—
—
—
0
0
0
6
0.00
0.00
0.0
1.7
—
—
—
0
0
0
5
0.00
0.00
0.0
1.8
—
—
—
0
0
0
8
0.00
0.00
0.0
1.3
—
—
—
0
0
5
52
0.96
0.00
1.0
1.7
—
—
—
0
0
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.9
—
—
—
0
0
0
7
0.00
0.00
0.0
1.6
—
—
—
0
0
0
7
0.00
0.00
0.0
1.6
—
—
—
0
0
0
6
0.00
0.00
0.0
1.5
—
—
—
0
0
5
51
0.98
0.00
1.0
1.6
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
9
94
0.96
0.00
2.6
1.6
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
7.9
—
0
5
(3011547) Coagulation factor VII activity actual/normal in Platelet poor plasma by Coagulation assay
0
7
0.00
0.00
0.0
1.0
—
128.0
—
0
7
Mortality – FinRegistry
↥Association
Association between endpoint N14_RENALCOLNAS and mortality.
Females
No dataMales
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| N14_RENALCOLNAS | 0.872 [0.68, 1.11] | 0.268 |
| Birth year | 0.99 [0.98, 1.0] | 0.039 |
During the follow-up period (1.1.1998 — 31.12.2019), 90 out of 836 males with N14_RENALCOLNAS died.
Mortality risk
Mortality risk for people of age
years, who have N14_RENALCOLNAS.| N-year risk | Females | Males |
|---|---|---|
| 1 | No data | 0.145% |
| 5 | No data | 1.102% |
| 10 | No data | 2.804% |
| 15 | No data | 5.38% |
| 20 | No data | 9.006% |
Relationships between endpoints
↥Index endpoint: N14_RENALCOLNAS – Unspecified renal colic
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data