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Malignant neoplasm of base of tongue, excluding all cancers (controls excluding all cancers)

C3_BASEOFTONGUE_EXALLC

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 C01&
  • Hospital discharge: ICD-9 1410A
  • Hospital discharge: ICD-8 1410
  • Cause of death: ICD-10 C01&
  • Cause of death: ICD-9 1410A
  • Cause of death: ICD-8 1410
  • Cancer registry: Topography ICD-O-3 C01
  • Cancer registry: Morphology ICD-O-3 ANY
  • Cancer registry: Behaviour codes 3

3 out of 7 registries used, show all original rules.

290

4. Check minimum number of events

None

290

5. Include endpoints

None

290

6. Filter based on genotype QC (FinnGen only)

290

Control definitions (FinnGen only)

Control exclude
C3_CANCER, C3_CANCER_WIDE_EXALLC

Extra metadata

First used in FinnGen datafreeze
DF12

Similar endpoints

List of similar endpoints to Malignant neoplasm of base of tongue, excluding all cancers (controls excluding all cancers) based on the number of shared cases.

Venn diagram with an highlighted set fully inside another set Similar with more cases:

Venn diagram with a set fully inside an highlighted set Similar with less cases:

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

-FinnGen-

Key figures

All Female Male
Number of individuals 290 79 211
Unadjusted period prevalence (%) 0.08 0.03 0.09
Median age at first event (years) 62.59 62.58 62.59

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
180
Matched controls
1801
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
C01
ICD-10 Finland
Malignant neoplasm of base of tongue
+∞
198.7
152
*
130
Kela drug reimbursment
Malignant tumour
+∞
171.4
136
*
8070/3-C01.9
ICD-O-3
Squamous cell carcinoma, NOS, of base of tongue, NOS
+∞
160.3
129
*
504
Kela drug reimbursment
Conditions requiring daily forced enteral nutrition
1437.3
132.6
113
*
JDB10
NOMESCO Finland
Percutaneous gastrostomy
1048.1
109.0
96
*
WF002
NOMESCO Finland
Radical radiotherapy
+∞
104.7
90
*
A03FA01
ATC
metoclopramide; systemic, rectal
42.8
87.9
115
71
UJC01
NOMESCO Finland
Scopy of lower throat
414.6
79.3
74
*
WB103
NOMESCO Finland
Simple adjuvant cytostatic therapy
+∞
73.0
65
*
N02AA05
ATC
oxycodone; systemic
25.6
67.1
102
87
EJA10
NOMESCO Finland
Biopsy of tongue or floor of mouth
98.9
56.4
60
9
H02AB02
ATC
dexamethasone; systemic
134.1
54.5
56
6
WZC00
NOMESCO Finland
Planning of intervention or health care consultation
11.9
48.8
116
237
ZX012
NOMESCO Finland
Radiotherapy with large shaped fields - isocentric therapy
+∞
48.1
44
*
C77.0
ICD-10 Finland
Secondary and unspecified malignant neoplasm: Lymph nodes of head, face and neck
+∞
47.0
43
*
A04AA01
ATC
ondansetron; systemic, rectal
108.0
45.5
48
6
A04AA02
ATC
granisetron; systemic, transdermal
537.7
44.2
42
*
YA1BD
NOMESCO Finland
Extensive CT examination of head and neck for dose design of radiotherapy
+∞
41.2
38
*
WF003
NOMESCO Finland
Adjuvant radiotherapy
+∞
40.1
37
*
R4190
NOMESCO Finland
Nutritional therapy
43.0
39.1
48
15
R22.1
ICD-10 Finland
Localized swelling, mass and lump, neck
29.9
38.5
52
24
YA1VG
NOMESCO Finland
MRI examination of head and neck with high intesity magnet for dose design of radiotherapy
+∞
37.9
35
*
EP1AE
NOMESCO Finland
Neck ultrasound examination
27.6
37.6
52
26
N02AB03
ATC
fentanyl; nasal, sublingual, transdermal
55.8
37.0
43
10
XX3DW
NOMESCO Finland
Time consuming IT work
24.5
36.9
53
30
GDA98
NOMESCO Finland
Other bronchoscopic incision, excision of lesion or repair of lung
436.9
36.3
35
*
EJB20
NOMESCO Finland
Excision of lesion of base of tongue
+∞
34.5
32
*
ZX090
NOMESCO Finland
Other technic of radiotherapy
+∞
34.5
32
*
EN1BD
NOMESCO Finland
Very extensive CT examination of mouth and soft tissues of neck
92.4
34.3
37
5
WZC20
NOMESCO Finland
Multidisciplinary treatment meeting
38.4
29.5
37
12
WX408
NOMESCO Finland
General anesthesy, balanced
7.0
29.5
91
228
PJD81
NOMESCO Finland
Excision of lymph nodes from upper part of neck
+∞
28.9
27
*
EP1CG
NOMESCO Finland
Extensive MRI examination of soft tissue of neck with high intesity magnet
119.2
28.6
30
*
GBB00
NOMESCO Finland
Tracheostomy
57.3
28.6
33
7
ZX095
NOMESCO Finland
Combined chemoradiotherapy
+∞
27.8
26
*
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
5.9
27.6
117
429
A04AD12
ATC
aprepitant; systemic
+∞
26.7
25
*
JN5DR
NOMESCO Finland
PET-CT of upper body metabolism
+∞
26.7
25
*
A07AA02
ATC
nystatin; oral
15.3
24.9
42
35
YA1CD
NOMESCO Finland
Very extensive CT examination of head and neck for dose design of radiotherapy
+∞
24.5
23
*
YA1AD
NOMESCO Finland
CT examination of head and neck for dose design of radiotherapy
+∞
24.5
23
*
PJD71
NOMESCO Finland
Extended sparing excision of cervical lymph nodes
+∞
24.5
23
*
WZC30
NOMESCO Finland
Teaching
8.6
24.5
58
94
ENA10
NOMESCO Finland
Biopsy of pharynx
275.1
24.3
24
*
ZX070
NOMESCO Finland
Intensity modified radiotherapy
+∞
23.4
22
*
C02.11
ICD-10 Finland
Malignant neoplasm of border of tongue
+∞
23.4
22
*
UDQ12
NOMESCO Finland
Flexible laryngoscopy
11.4
23.1
45
51
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
10.9
23.0
46
55
EBA15
NOMESCO Finland
Extraction of large number of teeth
13.6
22.6
40
37
SAA03
NOMESCO Finland
Extended examination of mouth
4.9
22.4
108
421
EP1DG
NOMESCO Finland
Very extensive examination of soft tissue of neck with high intesity magnet
131.0
22.1
23
*
R2130
NOMESCO Finland
Counselling and guidance which enhance independent living
10.4
21.6
44
54
K08.1
ICD-10 Finland
Loss of teeth due to accident, extraction or local periodontal disease
8.3
21.4
51
82
JCW98
NOMESCO Finland
Other transluminal endoscopic procedure on oesophagus
+∞
21.3
20
*
WD105
NOMESCO Finland
Cystostatic therapy of methastized malignancy
236.2
21.0
21
*
JN4KR
NOMESCO Finland
Whole body very extensive metabolic PET with CT
+∞
20.2
19
*
D10.10
ICD-10 Finland
Benign tumor at the base of the tongue
+∞
18.0
17
*
WF049
NOMESCO Finland
Radiotherapy of metastasis
+∞
18.0
17
*
WX402
NOMESCO Finland
General anaesthesia
5.7
17.5
56
132
GD1BD
NOMESCO Finland
Thorax extensive CT-examination
12.2
17.0
31
30
D37.08
ICD-10 Finland
Tumor of uncertain or unknown nature in other part of lip, oral cavity and pharynx
+∞
16.9
16
*
A04AA55
ATC
palonosetron, combinations; systemic
+∞
16.9
16
*
QA1S1
NOMESCO Finland
Photography of skin or subcutaneous tissue in head
99.5
16.9
18
*
WZC10
NOMESCO Finland
Extensive specialist consultion with written report
17.6
16.8
26
17
EMB10
NOMESCO Finland
Tonsillectomy
13.6
16.8
29
25
K04.5
ICD-10 Finland
Chronic apical periodontitis
4.2
16.5
78
275
A06AD11
ATC
lactulose; oral
5.4
16.0
53
129
OAB73
NOMESCO Finland
Prevention and treatment of malnutrition
+∞
15.9
15
*
C78.0
ICD-10 Finland
Secondary malignant neoplasm of lung
+∞
15.9
15
*
WD125
NOMESCO Finland
Demanding cystostatic therapy of methastized malignancy
174.5
15.7
16
*
UDH02
NOMESCO Finland
Rhinopharyngoscopy
7.9
15.3
36
55
PJD51
NOMESCO Finland
Block dissection of cervical lymph nodes
+∞
14.8
14
*
C02.9
ICD-10 Finland
Malignant neoplasm: Tongue, unspecified
+∞
14.8
14
*
8140/3-C61.9
ICD-O-3
Adenocarcinoma, NOS, of prostate gland
+∞
14.8
14
*
Z51.5
ICD-10 Finland
Palliative care
19.6
14.2
21
12
C79.8
ICD-10 Finland
Secondary malignant neoplasm of other specified sites
+∞
13.7
13
*
WF004
NOMESCO Finland
Palliative radiotherapy
+∞
13.7
13
*
WD405
NOMESCO Finland
Simple antiboidy therapy of methastized malignancy
+∞
13.7
13
*
C61
ICD-10 Finland
Malignant neoplasm of prostate
150.9
13.6
14
*
EBA10
NOMESCO Finland
Surgical removal of tooth
6.8
13.4
35
62
R13
ICD-10 Finland
Dysphagia
7.4
13.2
32
51
WX002
NOMESCO Finland
Sedation and analgesia
4.1
13.0
58
187
C02.8
ICD-10 Finland
Malignant neoplasm: Overlapping lesion of tongue
+∞
12.6
12
*
C02.4
ICD-10 Finland
Malignant neoplasm: Lingual tonsil
+∞
12.6
12
*
EN1AD
NOMESCO Finland
CT examination of mouth and soft tissues of neck
40.6
12.4
15
*
ZXC96
NOMESCO Finland
Robot assisted procedure
50.2
12.1
14
*
SBB00
NOMESCO Finland
Fotograf of mouth and teeth
13.1
11.7
20
17
JN4JR
NOMESCO Finland
Whole body extensive metabolic PET with CT
+∞
11.6
11
*
WX110
NOMESCO Finland
Local anesthesy
3.1
11.3
131
829
WW500
NOMESCO Finland
Blood transfusion
13.1
11.1
19
16
Z71.3
ICD-10 Finland
Dietary counselling and surveillance
9.5
10.9
22
26
PJ3AT
NOMESCO Finland
Cytology of lymphnode with ultrasound guidance
116.5
10.5
11
*
WZC05
NOMESCO Finland
Specialty-specific consultation based on referral by dentist or doctor
8.8
10.5
22
28
SBB10
NOMESCO Finland
Teeth copy
8.8
10.5
22
28
SCA02
NOMESCO Finland
Analysis and advice of nutrition with regard to dentistry
5.6
10.2
30
62
WX404
NOMESCO Finland
Intravenous generell anesthesy
3.9
10.0
44
138
K05.31
ICD-10 Finland
Periodontitis pronounced
4.3
9.9
38
105
UGC12
NOMESCO Finland
Flexible bronchoscopy
5.3
9.8
30
65
K05.30
ICD-10 Finland
Periodontitis complex
4.1
9.8
40
117
D10.19
ICD-10 Finland
Benign tumor of the tongue UNS
58.2
9.8
11
*
8085/3-C01.9
ICD-O-3
Squamous cell carcinoma, HPV positive of base of tongue, NOS
+∞
9.5
9
*
WD415
NOMESCO Finland
Demanding antibody therapy of methastized malignancy
+∞
9.5
9
*
TJD20
NOMESCO Finland
Change of gastrostomy tube
+∞
9.5
9
*
L03AA13
ATC
pegfilgrastim; parenteral
+∞
9.5
9
*
TJD00
NOMESCO Finland
Insertion of nasogastric or naso-gastroduodenal tube
19.9
9.1
13
7
R07.0
ICD-10 Finland
Pain in throat
7.9
9.0
20
28
R59.0
ICD-10 Finland
Localized enlarged lymph nodes
15.0
8.8
14
10
ZXE20
NOMESCO Finland
More than three and less than five hours
4.0
8.7
36
106
JN6AD
NOMESCO Finland
CT of torso and neck
94.3
8.5
9
*
ZZQ00
NOMESCO Finland
Free microvascular graft of skin
+∞
8.4
8
*
116
Kela drug reimbursment
Prostate cancer
+∞
8.4
8
*
K10.26
ICD-10 Finland
Periostitis of jaw (acute)(chronic)(suppurative)
+∞
8.4
8
*
EBB15
NOMESCO Finland
Insertion of dental implant abutment
+∞
8.4
8
*
K11.70
ICD-10 Finland
Hypoptyalism
+∞
8.4
8
*
YX9AD
NOMESCO Finland
Other CT eamination for dose design of radiotherapy
+∞
8.4
8
*
C02.10
ICD-10 Finland
Malignant neoplasm of tip of tongue
+∞
8.4
8
*
WX707
NOMESCO Finland
Fiberoscopic intubation
+∞
8.4
8
*
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.8
8.4
63
288
ED1AA
NOMESCO Finland
Mandipular X-ray examination
35.1
8.2
10
*
ZXE10
NOMESCO Finland
More than one and less than three hours
2.6
8.1
74
377
SXB00
NOMESCO Finland
Removeal of sutres from oral mucosa
5.5
7.9
23
47
ZXE00
NOMESCO Finland
One hour or less
2.6
7.9
79
421
EB1BI
NOMESCO Finland
Cone beam imaging of teeth and jaws (1–2 quarters)
47.1
7.8
9
*
SCA04
NOMESCO Finland
Guidance on care of mouth and oral mucosa
47.1
7.8
9
*
JN4BD
NOMESCO Finland
Extensive body CT
5.5
7.7
22
44
TPX10
NOMESCO Finland
Implantation of vascular injection port
19.4
7.7
11
6
UDQ22
NOMESCO Finland
Microlaryngoscopy
14.2
7.5
12
9
GD5BD
NOMESCO Finland
Thorax and upper abdomen combined extensive CT examination of
14.2
7.5
12
9
D10.5
ICD-10 Finland
Benign neoplasm: Other parts of oropharynx
+∞
7.3
7
*
9680/3-C01.9
ICD-O-3
Diffuse large B-cell lymphoma, NOS, of base of tongue, NOS
+∞
7.3
7
*
QA7S1
NOMESCO Finland
Photography of skin or subcutaneous tissue in jaw or lips
+∞
7.3
7
*
C83.31
ICD-10 Finland
Diffuse lymphoma with large B cells
+∞
7.3
7
*
SAA04
NOMESCO Finland
Special inverstigation of mouth
7.1
7.3
17
26
JN4AD
NOMESCO Finland
Body CT examination
8.5
7.3
15
19
ECB20
NOMESCO Finland
Oral alveoplasty
31.4
7.2
9
*
L03AA02
ATC
filgrastim; parenteral
31.4
7.2
9
*
A02BC05
ATC
esomeprazole; systemic
2.4
7.2
82
463
R4110
NOMESCO Finland
Physiotherapy
2.7
7.1
56
258
Z3226
NOMESCO Finland
Physiotherapist
3.0
6.9
42
166
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.3
6.7
85
501
WX105
NOMESCO Finland
Surface analgesia on skin or mucosa
3.8
6.6
28
84
EBA00
NOMESCO Finland
Extraction of tooth
2.4
6.6
67
354
ZXD10
NOMESCO Finland
Scheduled procedure
2.3
6.5
75
420
J02AC01
ATC
fluconazole; systemic
2.5
6.5
63
323
JN4CD
NOMESCO Finland
Very extensive body CT
15.0
6.5
10
7
UJC02
NOMESCO Finland
Rigid oesophagoscopy
15.0
6.5
10
7
GD6BD
NOMESCO Finland
Extensive CT of chest and neck
72.3
6.5
7
*
WD305
NOMESCO Finland
Simple therapy of methastized malignancy with biomodifiers
72.3
6.5
7
*
K02.1
ICD-10 Finland
Caries of dentine
2.2
6.4
104
684
Z2446
NOMESCO Finland
Social worker
4.9
6.4
20
45
R21
ICPC
Throat symptom/complaint
3.1
6.3
35
129
YX9BD
NOMESCO Finland
Other extensive CT eamination for dose design of radiotherapy
+∞
6.3
6
*
ZXF99
NOMESCO Finland
Other r3eason to interrupt procedure
+∞
6.3
6
*
UJC20
NOMESCO Finland
Extensive endoscopy to identify diagnosed or suspected primary malignant neoplasm of head or neck
+∞
6.3
6
*
K10.21
ICD-10 Finland
Osteoradionecrosis of jaw (acute)(chronic)(suppurative)
+∞
6.3
6
*
SXC03
NOMESCO Finland
Other oral or dental procedure
27.7
6.3
8
*
T05
ICPC
Feeding problem of adult
27.7
6.3
8
*
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
2.9
6.2
41
167
ZXE04
NOMESCO Finland
Procedure duration 30 to 39 minutes
4.9
6.2
19
42

Mortality – FinRegistry

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

Relationships between endpoints

Index endpoint: C3_BASEOFTONGUE_EXALLC – Malignant neoplasm of base of tongue, excluding all cancers (controls excluding all cancers)

GWS hits: -

This endpoint is excluded from FinRegistry analyses (omitted endpoint).