Waldenstrom macroglobulinemia, lymphoplasmacytic lymphoma, including Hilmo

C3_MACROGLOBULINEMIA_WIDE

Endpoint definition

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

519972

1. Apply sex-specific rule

None

519972

2. Check conditions

None

519972

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 C88.0
  • Hospital discharge: ICD-9 2733A
  • Cause of death: ICD-10 C88.0
  • Cause of death: ICD-9 2733A
  • Cancer registry: Topography ICD-O-3 ANY
  • Cancer registry: Morphology ICD-O-3 9761|9671
  • Cancer registry: Behaviour codes 3

3 out of 7 registries used, show all original rules.

276

4. Check minimum number of events

None

276

5. Include endpoints

None

276

6. Filter based on genotype QC (FinnGen only)

261

Control definitions (FinnGen only)

Control exclude
C3_CANCER, C3_CANCER_WIDE

Extra metadata

First used in FinnGen datafreeze
DF12

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

This endpoint is excluded (different definition than used in FinnGen).

-FinnGen-

Key figures

All Female Male
Number of individuals 261 102 159
Unadjusted period prevalence (%) 0.06 0.04 0.07
Median age at first event (years) 69.13 66.49 70.82

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
276
Matched controls
2760
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
C88.0
ICD-10 Finland
Waldenström macroglobulinaemia
+∞
307.7
256
*
117
Kela drug reimbursment
Leukaemia and other malignant diseases of the blood and bone marrow, and malignant diseases of the lymphatic tissue
148.2
291.8
150
22
XW000
NOMESCO Finland
Bone marrow biopsy
74.8
251.8
148
42
D47.2
ICD-10 Finland
Monoclonal gammopathy of undetermined significance (MGUS)
130.9
174.9
89
10
A04AA01
ATC
ondansetron; systemic, rectal
44.9
125.6
78
24
H02AB02
ATC
dexamethasone; systemic
60.0
106.7
61
13
9761/3-C42.0
ICD-O-3
Waldenstrom macroglobulinemia of blood
+∞
103.9
93
*
R70.0
ICD-10 Finland
Elevated erythrocyte sedimentation rate
24.7
85.9
65
34
L03AA02
ATC
filgrastim; parenteral
+∞
53.9
50
*
TNE25
NOMESCO Finland
Drill biopsy of bone marrow, pelvis
116.6
53.1
56
6
WW500
NOMESCO Finland
Blood transfusion
19.9
50.7
41
24
WD405
NOMESCO Finland
Simple antiboidy therapy of methastized malignancy
+∞
48.4
45
*
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
7.3
47.5
87
164
JN4BD
NOMESCO Finland
Extensive body CT
9.7
44.3
58
74
9671/3-C42.1
ICD-O-3
Lymphoplasmacytic lymphoma of bone marrow
+∞
43.9
41
*
WD415
NOMESCO Finland
Demanding antibody therapy of methastized malignancy
+∞
43.9
41
*
WD105
NOMESCO Finland
Cystostatic therapy of methastized malignancy
219.3
37.8
38
*
JN4AD
NOMESCO Finland
Body CT examination
8.0
37.8
58
89
J01EE01
ATC
sulfamethoxazole and trimethoprim; systemic
8.8
33.8
46
61
L03AA13
ATC
pegfilgrastim; parenteral
193.0
33.5
34
*
M04AA01
ATC
allopurinol; systemic
4.7
31.9
99
291
ZX120
NOMESCO Finland
Intravenous
7.1
31.1
52
87
WD125
NOMESCO Finland
Demanding cystostatic therapy of methastized malignancy
324.3
29.4
29
*
R50.9
ICD-10 Finland
Fever, unspecified
5.0
29.3
79
206
C61
ICD-10 Finland
Malignant neoplasm of prostate
+∞
28.6
27
*
1512
Kela drug reimbursment
Ibrutinib
+∞
27.6
26
*
390
Kela drug reimbursment
Ibrutinib
+∞
27.6
26
*
8140/3-C61.9
ICD-O-3
Adenocarcinoma, NOS, of prostate gland
+∞
26.5
25
*
C83.01
ICD-10 Finland
Lymphoplasmacytic lymphoma
+∞
25.4
24
*
D64.9
ICD-10 Finland
Anaemia, unspecified
4.6
24.7
70
188
A03FA01
ATC
metoclopramide; systemic, rectal
4.6
23.3
65
172
J05AB01
ATC
aciclovir; systemic
3.8
23.3
98
350
C90.0
ICD-10 Finland
Multiple myeloma
+∞
23.3
22
*
L01EL01
ATC
ibrutinib; oral
+∞
23.3
22
*
WZC00
NOMESCO Finland
Treatment plan or consultation
3.6
23.2
110
425
JN6AD
NOMESCO Finland
CT of torso and neck
44.2
23.1
28
7
L01AA02
ATC
chlorambucil; oral
+∞
22.2
21
*
C83.31
ICD-10 Finland
Diffuse lymphoma with large B cells
+∞
22.2
21
*
A04AA02
ATC
granisetron; systemic, transdermal
+∞
22.2
21
*
J05AB11
ATC
valaciclovir; oral
4.0
20.3
70
216
8090/3-C44.9
ICD-O-3
Basal cell carcinoma, NOS, of skin, NOS
+∞
20.0
19
*
EP1AE
NOMESCO Finland
Neck ultrasound examination
7.3
20.0
31
47
XZZ00
NOMESCO Finland
Active surveillance of a diagnosed cancer
+∞
19.0
18
*
C88.9
ICD-10 Finland
Malignant immunoproliferative disease, unspecified
+∞
17.9
17
*
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
5.2
15.6
34
72
A49.9
ICD-10 Finland
Bacterial infection, unspecified
3.7
15.1
55
174
1XC02, ,
NOMESCO Finland
60.1
15.0
17
*
B03XA02
ATC
darbepoetin alfa; parenteral
19.8
15.0
22
12
N08.1*C88.0
ICD-10 Finland
Glomerular disorders in Waldenström's macroglobulinaemia
+∞
14.7
14
*
QAE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin in head or neck
6.9
14.3
23
36
B03XA01
ATC
erythropoietin; parenteral
45.0
14.3
17
*
ZX012
NOMESCO Finland
Radiotherapy with large shaped fields - isocentric therapy
79.2
13.7
15
*
WD135
NOMESCO Finland
Demanding cystostatic therapy of methastized malignancy
+∞
13.7
13
*
130
Kela drug reimbursment
Malignant tumour
+∞
13.7
13
*
WD115
NOMESCO Finland
Multiple cystostatic therapy of methastized malignancy
+∞
13.7
13
*
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.6
13.6
163
980
C44.31
ICD-10 Finland
Basocellular carcinoma of the skin on another or unspecified part of the face
33.8
12.7
16
5
L01AA01
ATC
cyclophosphamide; systemic
73.3
12.7
14
*
TPH04
NOMESCO Finland
Cathetrisation of vein
2.8
12.6
81
356
116
Kela drug reimbursment
Prostate cancer
+∞
12.6
12
*
J01MA12
ATC
levofloxacin; systemic
2.8
12.2
75
322
H02AB06
ATC
prednisolone; systemic
2.5
12.1
157
962
WD305
NOMESCO Finland
Simple therapy of methastized malignancy with biomodifiers
+∞
11.5
11
*
C85.1
ICD-10 Finland
B-cell lymphoma, unspecified
+∞
11.5
11
*
L01XE27
ATC
[U] ibrutinib
+∞
11.5
11
*
L03AA14
ATC
lipegfilgrastim; parenteral
+∞
11.5
11
*
WZC20
NOMESCO Finland
Multidisciplinary treatment meeting
11.3
11.5
21
20
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.5
11.4
106
556
D70.82
ICD-10 Finland
Drug-induced neutropenia
62.5
10.7
12
*
NJ3DA
NOMESCO Finland
Long bones of extremities X-ray examination
62.5
10.7
12
*
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
3.7
10.7
36
107
JN6BD
NOMESCO Finland
Extensive CT of torso and neck
114.2
10.5
11
*
C83.9
ICD-10 Finland
Non-follicular (diffuse) lymphoma, unspecified
+∞
10.5
10
*
C91.1
ICD-10 Finland
Chronic lymphocytic leukaemia of B-cell type
+∞
10.5
10
*
C83.3
ICD-10 Finland
Diffuse large B-cell lymphoma
+∞
10.5
10
*
WF003
NOMESCO Finland
Adjuvant radiotherapy
+∞
10.5
10
*
C85.9
ICD-10 Finland
Non-Hodgkin lymphoma, unspecified
+∞
10.5
10
*
NEA10
NOMESCO Finland
Exploration of soft tissue of pelvis, percutaneous
34.0
10.4
13
*
XX3DW
NOMESCO Finland
Time consuming IT work
4.6
10.3
25
58
GD1AD
NOMESCO Finland
Thorax CT examination
4.3
10.0
27
68
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
2.6
9.9
71
326
B02.9
ICD-10 Finland
Zoster without complication
3.5
9.9
36
113
J18.9
ICD-10 Finland
Pneumonia, unspecified
2.3
9.5
102
562
PJA12
NOMESCO Finland
Sentinel node biopsy
103.4
9.5
10
*
WD325
NOMESCO Finland
Demanding therapy of methastized malignancy with biomodifiers
+∞
9.4
9
*
115
Kela drug reimbursment
Breast cancer
+∞
9.4
9
*
A04AD12
ATC
aprepitant; systemic
+∞
9.4
9
*
C83.80
ICD-10 Finland
B-cell lymphoma in marginal zone
+∞
9.4
9
*
C64.88
ICD-10 Finland
Other malignant neoplasm of kidney, except renal pelvis
+∞
9.4
9
*
PJ2AE
NOMESCO Finland
Lymphnode ultrasound examination
+∞
9.4
9
*
C83.1
ICD-10 Finland
Mantle cell lymphoma
+∞
9.4
9
*
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
3.6
9.4
33
101
WF002
NOMESCO Finland
Radical radiotherapy
38.0
9.1
11
*
R91
ICD-10 Finland
Abnormal findings on diagnostic imaging of lung
3.1
9.0
41
148
G62.9
ICD-10 Finland
Polyneuropathy, unspecified
4.1
8.9
25
65
JN3AD
NOMESCO Finland
Abdominal CT examination
3.1
8.8
40
144
A02BC02
ATC
pantoprazole; systemic
2.3
8.7
203
1507
WX408
NOMESCO Finland
General anesthesy, balanced
2.3
8.5
77
391
D48.5
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Skin
4.7
8.5
20
45
L02AE02
ATC
leuprorelin; implant, parenteral
92.8
8.5
9
*
XW4XT
NOMESCO Finland
Biopsy of other inner organ with radiological guidance guidance
+∞
8.4
8
*
C83.0
ICD-10 Finland
Small cell B-cell lymphoma
+∞
8.4
8
*
ZX108
NOMESCO Finland
Inhalation
34.5
8.1
10
*
WZC30
NOMESCO Finland
Teaching
2.8
8.0
44
176
Z51.5
ICD-10 Finland
Palliative care
4.3
8.0
21
52
HAB40
NOMESCO Finland
Wedge excision of mammary gland
46.3
7.8
9
*
GD1DD
NOMESCO Finland
High resolution CT examination of lungs
3.6
7.7
26
77
L57.0
ICD-10 Finland
Actinic keratosis
3.0
7.7
36
131
NK6AN
NOMESCO Finland
Total body bone isotope imaging
82.2
7.5
8
*
D38.1
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Trachea, bronchus and lung
13.9
7.5
12
9
B01AB10
ATC
tinzaparin; parenteral
3.2
7.4
31
106
C83.00
ICD-10 Finland
Lymphocytic lymphoma
+∞
7.3
7
*
9591/3-C42.1
ICD-O-3
Malignant lymphoma, non-Hodgkin, NOS, of bone marrow
+∞
7.3
7
*
L01BB05
ATC
fludarabine; systemic
+∞
7.3
7
*
Z51.1
ICD-10 Finland
Chemotherapy session for neoplasm
+∞
7.3
7
*
WW300
NOMESCO Finland
Transfer of autologic stem cells
+∞
7.3
7
*
8090/3-C44.5
ICD-O-3
Basal cell carcinoma, NOS, of skin of trunk
+∞
7.3
7
*
A41.9
ICD-10 Finland
Sepsis, unspecified
4.0
6.9
20
53
JN4CD
NOMESCO Finland
Very extensive body CT
8.6
6.9
14
17
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
2.0
6.9
103
631
UJF30
NOMESCO Finland
Ileoscopy through colon
2.8
6.9
35
134
JN1CG
NOMESCO Finland
Extensive MRI examination of upper part of abdomen with high intensity magnet
9.7
6.9
13
14
R59.1
ICD-10 Finland
Generalized enlarged lymph nodes
17.2
6.8
10
6
N02AA05
ATC
oxycodone; systemic
2.3
6.8
55
265
R59.0
ICD-10 Finland
Localized enlarged lymph nodes
6.7
6.7
16
25
WX602
NOMESCO Finland
Repeated or continuing anesthesia shots throug a catheter
4.2
6.7
18
45
B01AB04
ATC
dalteparin; parenteral
4.2
6.7
18
45
J01CA04
ATC
amoxicillin; systemic
2.2
6.7
218
1741
WX402
NOMESCO Finland
General anaesthesia
2.4
6.7
51
239
D50.9
ICD-10 Finland
Iron deficiency anaemia, unspecified
3.1
6.6
29
102
TAB00
NOMESCO Finland
Lumbar puncture
3.9
6.5
19
51
DM1AA
NOMESCO Finland
Paranasal sinuses X-ray examination without contrast
5.8
6.4
17
31
UGC12
NOMESCO Finland
Flexible bronchoscopy
2.9
6.4
30
110
D70.89
ICD-10 Finland
Neutropenic splenomegaly
18.5
6.3
9
5
PJD52
NOMESCO Finland
Block dissection of axillary lymph nodes
+∞
6.3
6
*
C20.91
ICD-10 Finland
Malignant tumor of the rectum invasive carcinoma
+∞
6.3
6
*
8500/3-C50.9
ICD-O-3
Infiltrating duct carcinoma, NOS, of breast, NOS
+∞
6.3
6
*
L04AX04
ATC
lenalidomide; oral
+∞
6.3
6
*
L02BG04
ATC
letrozole; oral
+∞
6.3
6
*
8090/3-C44.3
ICD-O-3
Basal cell carcinoma, NOS, of skin of other and unspecified parts of face
+∞
6.3
6
*
WF004
NOMESCO Finland
Palliative radiotherapy
+∞
6.3
6
*
153
Kela drug reimbursment
Lenalidomid
+∞
6.3
6
*
WX2DD
NOMESCO Finland
Low-dose CT of skeleton in whole body
+∞
6.3
6
*
329
Kela drug reimbursment
Lenalidomide
+∞
6.3
6
*
WF049
NOMESCO Finland
Radiotherapy of metastasis
+∞
6.3
6
*
308
Kela drug reimbursment
Alprostadil, sildenafil and combination product containing aviptadil and phentolamine
+∞
6.3
6
*
212
Kela drug reimbursment
Gout
5.6
6.3
17
32
JN5DR
NOMESCO Finland
PET-CT of upper body metabolism
27.4
6.3
8
*
PJA10
NOMESCO Finland
Exploration of lymph nodes
27.4
6.3
8
*
GD1CT
NOMESCO Finland
Biopsy of the lung with CT guidance
27.4
6.3
8
*
UJF32
NOMESCO Finland
Coloscopy
2.0
6.1
78
448
AA1AA
NOMESCO Finland
Head X-ray examination
10.4
6.1
11
11
QAA05
NOMESCO Finland
Incision for biopsy of skin of head or neck
10.4
6.1
11
11

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
214
111
82.37
308.05
12.5
1.3
14.75
1.16
g/l
33.25
206
101
166
34
120.99
306.90
2.0
1.3
—
—
—
0
0
169
54
79.15
281.05
7.4
1.3
123.17
48.47
mg/l
3.61
141
45
168
53
79.45
280.28
7.3
1.3
8.26
0.98
ratio
—
8
5
169
55
77.68
279.56
7.3
1.3
35.29
35.01
mg/l
0.01
141
47
205
152
49.54
248.51
11.4
1.3
—
—
—
0
0
140
35
80.15
244.99
7.0
1.3
—
—
—
0
0
171
133
32.17
197.61
5.9
1.9
7.99
11.08
g/l
5.60
166
119
102
14
114.98
196.40
1.4
1.1
—
—
—
0
0
106
32
53.16
173.90
1.5
1.5
—
—
—
0
0
120
80
25.77
145.88
10.6
1.2
15.97
10.75
g/l
5.03
112
68
77
19
55.82
131.30
1.8
1.1
—
—
—
0
0
67
22
39.90
105.20
1.1
1.1
—
—
—
0
0
146
218
13.10
105.07
5.4
2.0
62.83
64.59
e9/l
0.22
115
170
84
51
23.24
104.77
1.6
1.3
—
—
—
0
0
166
296
12.56
103.75
5.3
1.9
1.65
1.66
%
0.03
157
268
104
102
15.76
99.76
2.5
1.6
1.41
1.54
g/l
0.57
94
91
90
74
17.56
95.65
11.2
1.2
37.87
37.78
g/l
0.04
82
62
162
348
9.85
83.47
4.1
1.2
1.70
2.96
g/l
3.31
145
196
104
144
10.98
76.98
2.0
1.3
—
—
—
0
0
80
79
13.85
75.14
1.5
1.3
—
—
—
0
0
115
187
9.83
74.57
1.9
1.4
—
—
—
0
0
100
142
10.48
72.22
1.9
1.4
—
—
—
0
0
233
929
10.68
60.27
17.4
5.4
—
—
—
0
0
234
1008
9.68
53.35
14.0
4.9
0.68
0.62
e9/l
2.22
219
871
178
600
6.54
53.06
6.1
2.6
1732.60
10571.64
umol/l
2.35
168
519
236
1029
9.93
52.99
14.1
5.0
1.99
1.79
e9/l
0.69
224
905
234
1014
9.59
52.80
14.0
4.9
0.04
0.04
e9/l
0.17
219
881
225
948
8.43
51.99
14.0
5.1
53.79
58.39
%
6.42
220
886
237
1049
9.91
51.98
14.8
5.0
0.17
0.20
e9/l
2.56
224
915
83
137
8.23
51.58
7.7
3.6
0.69
0.91
%
0.54
58
41
39
20
22.54
51.15
2.6
2.0
0.56
2.40
g/24h
—
22
10
114
271
6.46
49.44
9.1
4.8
1.05
1.01
mmol/l
0.66
107
241
238
1110
9.31
47.59
24.7
5.9
3.68
4.35
e9/l
2.67
222
968
50
5
121.59
47.57
1.4
1.0
—
—
—
0
0
44
0
+∞
47.26
1.7
0.0
14.43
—
titre
—
7
0
232
1072
8.30
46.32
17.5
5.6
1.21
1.21
mmol/l
0.36
195
934
72
118
7.90
44.63
8.2
3.8
0.33
0.33
%
-0.00
48
33
74
128
7.53
43.61
8.1
3.7
0.04
0.06
%
0.18
49
31
163
630
4.88
37.87
13.3
3.0
7.41
7.40
ph
0.99
39
97
109
309
5.18
37.44
3.7
2.4
24.79
23.31
%
0.44
101
268
207
1001
5.27
34.96
15.5
5.1
1.22
1.21
mmol/l
1.24
201
887
41
10
47.76
34.18
1.8
1.8
32.81
50.83
%
—
41
10
148
581
4.34
32.48
2.9
2.2
3.08
3.13
mg/l
0.08
129
488
62
121
6.32
31.93
8.3
3.7
0.00
0.04
%
0.49
37
27
102
315
4.55
30.70
5.0
2.9
0.81
0.82
mmol/l
0.70
96
292
30
25
13.34
30.37
2.7
1.5
32.93
33.44
pg
0.23
30
25
30
27
12.34
28.94
3.9
1.4
—
—
—
0
0
33
7
53.27
28.13
3.2
1.3
0.05
0.18
e9/l
—
33
7
177
856
3.98
27.44
4.7
2.6
203.78
132.91
ug/l
2.19
171
781
139
614
3.55
23.88
9.1
3.9
—
—
—
0
0
101
364
3.80
23.73
3.0
1.8
31.33
29.85
s
1.20
95
348
27
28
10.58
23.60
1.2
1.2
—
—
—
0
0
31
13
26.67
22.73
1.5
1.2
—
—
—
0
0
148
697
3.42
22.63
5.3
2.1
2.35
2.35
mmol/l
0.15
130
577
52
119
5.15
22.14
2.8
1.3
2.63
2.79
ug/l
0.15
38
94
26
7
40.75
21.18
1.3
1.1
—
—
—
0
0
162
894
2.97
17.41
4.9
2.3
—
—
—
0
0
36
74
5.44
17.15
2.0
2.1
1.29
0.20
g/l
0.53
21
21
123
601
2.89
16.34
5.6
2.1
—
—
—
0
0
231
1616
3.63
15.24
8.1
4.2
53.86
12.62
mm/h
34.53
219
1459
23
34
7.29
15.10
1.1
1.1
—
—
—
0
0
69
253
3.30
15.06
1.4
1.2
948.57
569.18
titre
—
7
61
120
601
2.76
14.92
2.6
1.5
—
—
—
0
0
158
910
2.72
14.86
25.7
7.9
0.00
0.00
e9/l
0.61
138
748
103
484
2.80
14.40
6.6
3.6
83.58
83.35
%
0.03
98
475
49
148
3.81
14.35
1.5
1.1
—
—
—
0
0
124
642
2.69
14.31
2.1
1.5
22.29
20.29
nmol/l
0.65
112
543
22
33
7.16
14.24
4.7
1.8
2.90
4.70
e9/l
2.68
22
33
22
33
7.16
14.24
6.0
2.3
52.09
59.36
%
1.03
22
33
26
27
10.51
13.55
1.6
1.2
—
—
—
0
0
20
12
17.85
13.19
4.2
1.9
496.30
976.92
e6/l
1.17
20
12
17
6
30.04
13.12
1.6
1.0
—
—
—
0
0
165
1019
2.54
12.74
2.6
2.1
95.02
93.43
pmol/l
0.14
103
526
29
64
4.95
12.68
1.4
1.3
—
—
—
0
0
132
748
2.47
12.11
5.8
3.6
65.09
115.84
e6/l
0.65
101
515
101
508
2.56
11.95
1.9
1.8
1134.49
1187.32
nmol/l
0.21
79
388
194
1317
2.59
11.87
10.5
4.4
6.32
6.86
mmol/l
5.44
189
1234
119
648
2.47
11.86
5.1
3.0
13.08
172.82
e6/l
0.89
98
478
92
451
2.56
11.41
14.6
4.5
—
—
—
0
0
107
564
2.47
11.35
4.8
2.8
—
—
—
0
0
109
593
2.39
10.65
4.9
2.8
0.76
0.46
e6/l
0.42
89
426
17
12
15.00
10.63
2.2
2.8
37.71
55.43
%
—
7
7
205
1474
2.52
10.34
5.9
4.1
—
—
—
0
0
21
42
5.33
10.22
1.5
1.1
—
—
—
0
0
87
435
2.46
10.19
4.1
2.3
3.20
4.35
e6/l
1.08
76
379
67
296
2.67
10.15
1.2
1.2
—
—
—
0
0
19
20
10.11
9.93
10.2
4.1
—
—
—
0
0
72
333
2.57
9.92
2.2
1.7
—
—
—
0
0
85
426
2.44
9.86
4.0
2.1
2.54
2.44
mmol/l
6.95
73
363
26
67
4.18
9.37
1.6
1.3
0.87
1.12
g/l
2.80
26
61
83
428
2.34
8.93
4.0
2.8
508.65
546.85
mosm/kgh2o
1.09
69
344
25
65
4.13
8.90
1.6
1.3
0.15
0.24
g/l
4.19
20
60
44
172
2.85
8.34
4.2
3.6
97.14
83.53
ng/l
0.34
37
147
131
836
2.08
8.10
3.7
3.2
1474.96
1524.48
ng/l
0.06
116
717
166
1156
2.09
8.10
19.3
17.5
1.23
1.38
inr
1.54
54
321
83
460
2.15
7.32
2.2
1.6
2.25
1.17
mg/l
0.46
69
360
84
475
2.10
6.99
1.6
1.3
—
—
—
0
0
35
133
2.87
6.96
2.3
2.5
—
—
—
0
0
13
15
9.03
6.63
2.6
2.1
—
—
—
0
0
13
15
9.03
6.63
1.2
1.1
—
—
—
0
0
49
228
2.40
6.50
10.6
3.7
—
—
—
0
0
64
334
2.19
6.49
1.4
1.3
58.41
35.43
iu/ml
0.26
15
99
16
28
6.00
6.24
1.4
1.1
313.00
224.08
u/ml
—
9
12
16
39
4.29
6.17
1.6
1.1
—
—
—
0
0
14
22
6.64
5.94
1.9
1.2
—
—
—
0
0
53
266
2.23
5.88
2.2
1.5
—
—
—
0
0
16
41
4.08
5.80
4.3
2.9
—
—
—
0
0
58
304
2.15
5.78
1.3
1.3
5.07
10.92
u/ml
0.59
19
107
17
46
3.87
5.74
3.8
2.8
—
—
—
0
0
13
20
6.76
5.62
1.2
1.2
—
—
—
0
0
13
21
6.44
5.45
2.3
1.1
—
—
—
0
0
106
700
1.83
5.39
3.6
2.1
60.33
63.67
u/l
0.16
99
642
50
254
2.18
5.37
1.8
1.7
—
—
—
0
0
32
133
2.59
5.36
3.5
2.8
3.26
4.17
e9/l
1.24
19
93
104
685
1.83
5.32
3.4
3.2
—
—
—
0
0
64
360
2.01
5.26
4.5
2.8
2.03
2.17
e6/l
0.06
39
190
15
40
3.91
5.16
1.1
1.8
—
—
—
0
0
10
12
8.60
5.10
1.3
1.3
—
—
—
0
0
37
169
2.37
5.09
2.5
1.9
0.15
0.20
g/l
2.61
30
149
13
24
5.63
4.98
1.0
1.0
—
—
—
0
0
245
2135
2.31
4.80
43.1
13.8
22.70
24.36
mg/l
0.43
233
1645
36
168
2.31
4.72
5.3
4.1
7.42
7.39
ph
—
9
16
7
5
14.31
4.60
4.0
1.0
—
—
—
0
0
7
5
14.31
4.60
1.0
1.0
—
—
—
0
0
17
54
3.29
4.57
2.6
3.2
—
—
—
0
0
119
845
1.72
4.55
3.8
3.5
—
5.71
—
0
40
38
185
2.22
4.51
13.5
6.7
—
—
—
0
0
139
1035
1.69
4.42
4.6
3.7
0.00
0.01
estimate
0.50
31
179
38
187
2.20
4.40
1.9
1.9
171.70
132.18
ug/g
0.29
27
141
14
33
4.41
4.39
1.2
2.0
1.14
1.09
g/l
—
9
28
141
1058
1.68
4.32
4.6
3.8
0.00
0.02
estimate
0.50
29
157
8
9
9.11
4.31
1.0
1.9
—
—
—
0
0
138
1039
1.66
4.11
6.3
5.1
0.00
0.00
estimate
-0.00
30
159
38
193
2.12
4.07
10.4
5.9
1.09
1.48
mmol/l
3.07
38
186
7
7
10.22
4.03
1.0
1.3
—
—
—
0
0
10
18
5.72
4.01
1.1
1.0
—
—
—
0
0
13
33
4.08
3.85
2.8
3.0
—
—
—
0
0
6
5
12.22
3.78
1.2
1.0
—
—
—
0
0
13
34
3.96
3.74
6.0
2.3
—
—
—
0
0
10
20
5.15
3.72
1.3
1.2
—
—
—
0
0
8
12
6.83
3.70
1.3
1.1
—
—
—
0
0
26
120
2.29
3.51
12.7
8.8
—
—
—
0
0
34
176
2.06
3.47
3.8
2.1
30.04
33.22
u/l
0.26
26
144
74
492
1.69
3.45
3.9
4.1
271.10
328.46
ng/l
0.11
60
419
49
291
1.83
3.37
10.7
5.8
104.67
104.37
mmol/l
0.19
49
291
37
200
1.98
3.36
1.2
1.2
—
—
—
0
0
32
168
2.02
3.15
6.3
3.4
—
—
—
0
0
48
291
1.79
3.08
9.9
6.4
0.90
1.58
mmol/l
0.82
41
230
19
81
2.45
3.06
1.9
1.8
—
—
—
0
0
158
1294
1.52
2.90
4.0
3.1
57.64
53.24
u/l
0.25
146
1180
6
9
6.78
2.88
1.0
1.2
—
—
—
0
0
6
9
6.78
2.88
1.0
1.2
—
—
—
0
0
74
515
1.60
2.84
4.4
3.6
—
—
—
0
0
8
18
4.54
2.81
2.4
1.2
—
—
—
0
0
24
119
2.11
2.76
13.8
8.1
24.21
24.85
mmol/l
0.60
24
112
97
726
1.52
2.68
4.9
4.3
—
—
—
0
0
40
241
1.77
2.63
6.1
3.0
1.87
2.16
mmol/l
0.18
33
206
7
16
4.46
2.49
2.6
1.3
—
—
—
0
0
124
991
1.46
2.43
5.5
4.1
51.00
45.61
ng/l
0.15
100
758
18
85
2.20
2.34
1.1
1.2
—
—
—
0
0
33
196
1.78
2.28
3.0
1.6
346.03
377.30
nmol/l
0.49
33
176
183
1591
1.45
2.18
3.7
3.6
14.75
15.06
pmol/l
0.96
161
1412
7
19
3.75
2.16
2.3
1.4
—
—
—
0
0
6
15
4.06
2.05
2.3
1.1
—
—
—
0
0
5
11
4.61
1.95
1.4
1.1
—
—
—
0
0
28
168
1.74
1.89
1.4
1.5
—
—
—
0
0
7
22
3.24
1.89
1.6
1.3
—
—
—
0
0
7
23
3.09
1.81
1.3
1.0
—
—
—
0
0
8
29
2.81
1.80
2.5
1.5
89.79
90.14
%
—
8
29
96
780
1.35
1.57
6.9
3.3
10189.48
135.51
mg/l
5.53
81
502
18
101
1.84
1.53
1.4
1.3
—
—
—
0
0
31
205
1.58
1.48
4.4
3.0
—
—
—
0
0
243
2286
1.53
1.48
44.7
16.4
91.47
82.98
umol/l
1.18
243
2286
7
28
2.54
1.46
1.0
1.0
—
—
—
0
0
216
1995
1.38
1.40
4.6
4.5
1.95
1.99
mu/l
0.17
200
1785
7
29
2.45
1.40
1.9
1.1
—
—
—
0
0
25
161
1.61
1.34
3.6
3.2
—
—
—
0
0
6
24
2.53
1.31
1.2
1.3
—
—
—
0
0
8
35
2.32
1.28
1.0
1.6
—
—
—
0
0
128
1110
1.29
1.26
4.6
4.0
2.04
2.01
ug/l
0.03
112
979
6
25
2.43
1.25
1.7
1.4
92.92
68.86
pmol/l
—
6
25
9
45
2.03
1.24
1.2
1.2
—
—
—
0
0
51
388
1.39
1.24
1.3
1.2
0.28
1.39
u/ml
—
5
105
27
181
1.55
1.24
5.8
4.6
—
—
—
0
0
5
20
2.53
1.15
1.4
1.7
—
—
—
0
0
20
128
1.61
1.12
6.4
4.2
—
—
—
0
0
67
541
1.31
1.12
4.3
3.5
—
—
—
0
0
11
59
1.90
1.09
2.4
2.7
—
—
—
0
0
7
33
2.15
1.06
3.4
5.1
6.40
6.28
mmol/l
—
7
26
11
60
1.87
1.04
3.7
3.6
—
—
—
0
0
12
68
1.80
1.02
1.8
1.6
—
—
—
0
0
0
29
0.00
0.98
0.0
3.9
—
345.00
—
0
24
9
50
1.83
0.97
1.1
1.5
—
—
—
0
0
67
552
1.28
0.96
1.5
1.8
483.35
422.15
pmol/l
1.01
54
449
20
135
1.52
0.92
1.3
1.2
—
—
—
0
0
8
43
1.89
0.88
1.1
1.1
—
—
—
0
0
12
73
1.67
0.83
3.8
4.7
—
—
—
0
0
57
678
0.80
0.77
2.7
3.4
—
—
—
0
0
19
133
1.46
0.76
3.5
3.7
—
—
—
0
0
5
24
2.10
0.75
1.0
1.2
—
—
nmol/l
—
0
0
5
25
2.02
0.73
1.2
1.0
301.00
241.79
ng/l
—
5
19
5
25
2.02
0.73
1.2
1.0
850.20
548.37
ng/l
—
5
19
232
2225
1.27
0.72
34.2
13.4
—
—
—
0
0
245
2366
1.32
0.71
58.6
20.2
238.74
239.21
e9/l
0.03
240
2286
245
2367
1.31
0.70
58.6
20.2
3.95
4.50
e12/l
32.87
238
2274
245
2367
1.31
0.70
59.5
20.3
36.14
40.13
%
17.24
232
2171
245
2367
1.31
0.70
58.6
20.2
6.75
6.77
e9/l
0.02
238
2278
9
59
1.54
0.69
1.1
1.2
—
—
—
0
0
51
600
0.82
0.62
1.7
1.6
1.43
1.34
mmol/l
0.17
45
486
65
562
1.20
0.62
5.8
3.9
0.00
0.02
estimate
0.50
25
157
16
220
0.71
0.61
1.7
1.5
—
—
—
0
0
0
20
0.00
0.60
0.0
1.1
—
—
—
0
0
0
21
0.00
0.60
0.0
1.1
—
—
—
0
0
0
21
0.00
0.60
0.0
1.1
—
—
—
0
0
0
21
0.00
0.60
0.0
1.1
—
—
—
0
0
0
21
0.00
0.60
0.0
1.1
—
—
—
0
0
15
106
1.44
0.59
4.8
4.5
—
—
—
0
0
12
82
1.48
0.55
2.3
1.8
—
—
—
0
0
6
96
0.62
0.53
1.0
1.2
—
98.22
—
0
37
172
1627
1.15
0.51
5.6
4.3
—
—
—
0
0
69
612
1.17
0.50
2.8
2.7
0.62
0.77
ug/l
1.43
51
420
6
91
0.65
0.43
1.7
1.4
—
—
—
0
0
86
786
1.14
0.41
4.0
3.2
6.89
7.55
mmol/l
0.72
77
637
0
16
0.00
0.41
0.0
1.1
—
—
—
0
0
205
2117
0.88
0.39
6.0
6.6
37.97
40.92
mmol/mol
7.66
187
1941
90
828
1.13
0.39
4.6
3.9
17.13
7.56
mg/mmol
0.91
63
524
31
265
1.19
0.35
2.5
2.8
7.14
8.01
ug/l
0.08
25
232
7
55
1.28
0.30
6.0
2.3
—
—
—
0
0
21
176
1.21
0.30
1.4
1.5
—
—
—
0
0
15
122
1.24
0.27
4.2
2.3
0.58
0.63
%
0.33
15
122
218
2228
0.90
0.27
4.7
5.6
2.32
2.59
mmol/l
5.37
201
2016
18
150
1.21
0.27
1.7
2.4
14.29
14.82
nmol/l
0.14
18
134
210
2148
0.91
0.25
4.1
4.9
1.39
1.43
mmol/l
0.76
191
1942
46
501
0.90
0.22
5.6
4.0
1.02
1.02
kg/l
—
10
75
5
41
1.22
0.22
3.8
2.8
—
—
—
0
0
0
10
0.00
0.21
0.0
1.5
—
—
—
0
0
0
12
0.00
0.21
0.0
1.0
—
—
—
0
0
0
12
0.00
0.21
0.0
1.1
—
37.08
—
0
6
5
43
1.17
0.21
3.8
2.7
4.36
4.09
mmol/l
—
5
43
5
43
1.17
0.21
3.8
2.7
105.60
105.44
mmol/l
—
5
43
213
2170
0.92
0.20
4.1
5.0
4.15
4.45
mmol/l
3.69
196
1975
0
14
0.00
0.20
0.0
1.9
—
79.93
—
0
14
15
127
1.19
0.20
4.2
2.4
1.07
1.11
%
0.09
15
127
5
67
0.74
0.17
1.0
1.1
—
—
—
0
0
9
78
1.16
0.15
1.2
1.1
—
—
—
0
0
205
2076
0.95
0.10
3.9
4.4
1.14
1.28
mmol/l
1.49
184
1862
5
48
1.04
0.09
6.6
1.7
63.36
67.04
%
—
5
48
12
132
0.90
0.07
1.2
1.3
—
—
—
0
0
220
2186
1.03
0.04
4.9
5.0
5.90
6.12
mmol/l
2.52
197
1953
175
1756
0.99
0.00
48.8
18.5
328.58
332.37
g/l
5.57
175
1741
0
7
0.00
-0.00
0.0
1.3
—
182.80
—
0
7
0
7
0.00
-0.00
0.0
9.0
—
985.86
—
0
7
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
8
79
1.01
-0.00
1.6
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.8
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
5
56
0.89
-0.00
1.6
1.7
—
—
—
0
0
0
7
0.00
-0.00
0.0
11.4
—
1587.71
—
0
7
0
5
0.00
-0.00
0.0
1.0
—
54.60
—
0
5
0
7
0.00
-0.00
0.0
7.1
—
0.69
—
0
7
0
6
0.00
-0.00
0.0
1.5
—
—
—
0
0

Mortality – FinRegistry

This endpoint is excluded (different definition than used in FinnGen).

Relationships between endpoints

Index endpoint: C3_MACROGLOBULINEMIA_WIDE – Waldenstrom macroglobulinemia, lymphoplasmacytic lymphoma, including Hilmo

GWS hits: 5

This endpoint is excluded (different definition than used in FinnGen).