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Benign neoplasm: Oesophagus

DOID EFO Endpoint Browser PheWeb

CD2_BENIGN_OESOPHAGUS

Endpoint definition

↥

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — D13.0&
  • Hospital discharge: ICD-9 — 2110
  • Hospital discharge: ICD-8 — 2110
  • Cause of death: ICD-10 — D13.0&
  • Cause of death: ICD-9 — 2110
  • Cause of death: ICD-8 — 2110

2 out of 7 registries used, show all original rules.

416

4. Check minimum number of events

None

416

5. Include endpoints

None

416

6. Filter based on genotype QC (FinnGen only)

416

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
D13
Name in latin
Neoplasma benignum oesophagi

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 2379 1167 1194
Only index persons 2084 1051 1033
Unadjusted period prevalence (%)
Whole population 0.03 0.03 0.03
Only index persons 0.04 0.04 0.04
Median age at first event (years)
Whole population 61.50 61.77 61.20
Only index persons 60.86 60.89 60.82

-FinnGen-

Key figures

All Female Male
Number of individuals 416 222 194
Unadjusted period prevalence (%) 0.08 0.08 0.09
Median age at first event (years) 61.02 58.92 63.42

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
383
Matched controls
3828
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
D13.0
ICD-10 Finland
Benign neoplasm: Oesophagus
+∞
323.0
371
*
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
15.7
121.9
307
783
C15.5
ICD-10 Finland
Malignant neoplasm: Lower third of oesophagus
78.2
37.8
42
6
D13.1
ICD-10 Finland
Benign neoplasm: Stomach
22.2
36.9
54
28
JD1EE
NOMESCO Finland
Ultrasound examination of gastro-oesophageal reflux
392.3
36.6
36
*
XJD02
NOMESCO Finland
Peroral endoscopic ultrasonography
65.9
31.7
36
6
K21.0
ICD-10 Finland
Gastro-oesophageal reflux disease with oesophagitis
5.3
28.6
97
230
JDW98
NOMESCO Finland
Other transluminal endoscopic operation on stomach or duodenum
17.9
25.1
39
24
JCA45
NOMESCO Finland
Endoscopic mucosal or submucosal resection in oesophagus
243.9
22.9
23
*
R13
ICD-10 Finland
Dysphagia
5.7
21.0
63
127
D37.7
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Other digestive organs
10.5
20.4
40
42
UJD02
NOMESCO Finland
Gastroscopy
6.2
19.5
54
98
K44.9
ICD-10 Finland
Diaphragmatic hernia without obstruction or gangrene
4.9
18.8
65
153
K22.7
ICD-10 Finland
Barrett oesophagus
21.3
18.0
26
13
A02BC02
ATC
pantoprazole; systemic
2.7
16.7
285
1998
A02BC05
ATC
esomeprazole; systemic
2.5
16.2
197
1141
UJF32
NOMESCO Finland
Coloscopy
2.7
16.0
140
674
C15.9
ICD-10 Finland
Malignant neoplasm: Oesophagus, unspecified
47.0
15.2
18
*
JCC12
NOMESCO Finland
Thoracoscopic or laparoscopic partial oesophagectomy
155.7
14.6
15
*
JCF12
NOMESCO Finland
Endoscopic insertion of prosthetic tube into oesphagus
23.3
14.4
20
9
UJC12
NOMESCO Finland
Flexible oesophagoscopy
18.4
14.0
21
12
A02BC01
ATC
omeprazole; systemic
2.5
13.7
137
698
K21.9
ICD-10 Finland
Gastro-oesophageal reflux disease without oesophagitis
3.5
13.5
68
224
K22.1
ICD-10 Finland
Ulcer of oesophagus
9.6
13.5
27
30
K22.2
ICD-10 Finland
Oesophageal obstruction
14.0
12.1
20
15
JDA05
NOMESCO Finland
Endoscopic polypectomy in stomach or pylorus
67.0
11.7
13
*
JCA05
NOMESCO Finland
Endoscopic polypectomy in oesophagus
+∞
10.5
10
*
TPH04
NOMESCO Finland
Cathetrisation of vein
2.4
10.4
104
519
A02BC03
ATC
lansoprazole; oral
2.1
9.5
135
787
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.0
9.4
188
1254
WX002
NOMESCO Finland
Sedation and analgesia
2.3
9.0
97
497
Z01.8
ICD-10 Finland
Other specified special examinations
2.3
8.9
97
499
K21
ICD-10 Finland
Gastro-oesophageal reflux disease
4.7
8.8
29
66
C15.4
ICD-10 Finland
Malignant neoplasm: Middle third of oesophagus
51.2
8.7
10
*
K57.3
ICD-10 Finland
Diverticular disease of large intestine without perforation or abscess
2.2
8.2
87
443
JC2AB
NOMESCO Finland
Oesophagus X-ray examination with contrast
10.4
8.1
15
15
K20
ICD-10 Finland
Oesophagitis
6.8
8.0
19
29
JCA55
NOMESCO Finland
Endoscopic dilatation of oesophagus
11.1
7.9
14
13
UJC02
NOMESCO Finland
Rigid oesophagoscopy
12.2
7.6
13
11
WX402
NOMESCO Finland
General anaesthesia
2.3
7.6
77
383
C15.3
ICD-10 Finland
Malignant neoplasm: Upper third of oesophagus
81.6
7.4
8
*
D13.3
ICD-10 Finland
Benign neoplasm: Other and unspecified parts of small intestine
81.6
7.4
8
*
D13.9
ICD-10 Finland
Benign neoplasm: Ill-defined sites within the digestive system
81.6
7.4
8
*
Z04.8
ICD-10 Finland
Examination and observation for other specified reasons
2.5
7.3
58
253
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.9
7.3
141
905
8070/3-C15.9
ICD-O-3
Squamous cell carcinoma, NOS, of esophagus, NOS
30.6
7.2
9
*
WX408
NOMESCO Finland
General anesthesy, balanced
1.9
7.2
116
700
C16.00
ICD-10 Finland
Cardia
20.5
7.2
10
5
R4190
NOMESCO Finland
Nutritional therapy
4.5
7.2
24
56
D50.9
ICD-10 Finland
Iron deficiency anaemia, unspecified
3.0
6.9
39
139
D12.6
ICD-10 Finland
Benign neoplasm: Colon, unspecified
3.4
6.9
32
100
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
2.8
6.9
43
163
H02AB06
ATC
prednisolone; systemic
1.8
6.9
179
1266
8140/3-C16.0
ICD-O-3
Adenocarcinoma, NOS, of cardia, NOS
17.1
6.8
10
6
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
2.1
6.7
77
403
D12.5
ICD-10 Finland
Benign neoplasm: Sigmoid colon
3.9
6.7
26
70
K90.0
ICD-10 Finland
Coeliac disease
5.0
6.6
20
42
504
Kela drug reimbursment
Conditions requiring daily forced enteral nutrition
8.9
6.6
13
15
D13.2
ICD-10 Finland
Benign neoplasm: Duodenum
10.3
6.6
12
12
R03BA01
ATC
beclometasone; inhalant
2.3
6.5
61
290
N02BE01
ATC
paracetamol; systemic, rectal
2.1
6.5
327
2833
8140/3-C15.9
ICD-O-3
Adenocarcinoma, NOS, of esophagus, NOS
71.0
6.4
7
*
JCA98
NOMESCO Finland
Other local endoscopic operation on oesophagus
71.0
6.4
7
*
JC2KB
NOMESCO Finland
Functional X-ray examination of swallowing
9.5
6.3
12
13
JDA52
NOMESCO Finland
Other endoscopic procedure using diathermy or heat in stomach or pylorus
+∞
6.3
6
*
JCA08
NOMESCO Finland
Endoscopic removal of foreign body from oesophagus
27.1
6.2
8
*
J45.1
ICD-10 Finland
Nonallergic asthma
2.9
6.2
36
132
K30
ICD-10 Finland
Functional dyspepsia
2.5
6.2
47
203
JN4BD
NOMESCO Finland
Extensive body CT
2.3
6.1
56
263
NB2AT
NOMESCO Finland
Intra artrial injection of shoulder with ultrasound guidance
12.8
6.1
10
8
J02AC01
ATC
fluconazole; systemic
1.8
6.1
144
978
WX302
NOMESCO Finland
Thoracal epidural anesthesy
3.2
6.0
30
100

LabWAS

↥
OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
177
475
5.75
65.92
2.1
1.2
—
—
—
0
0
249
1491
2.67
20.96
7.7
4.9
35.1
35.4
g/l
0.38
231
1392
277
1829
2.54
17.76
7.8
6.6
11.1
11.2
umol/l
0.07
266
1728
86
324
3.09
17.41
2.7
2.4
0.2
0.2
g/l
0.05
78
305
190
1079
2.40
16.78
3.0
2.6
54.4
56.7
u/l
0.49
171
1002
353
2667
3.14
16.58
10.2
7.6
79.5
79.0
u/l
0.10
330
2488
160
846
2.45
16.53
2.9
2.0
3.1
3.2
mg/l
0.28
144
722
97
420
2.71
15.05
10.6
6.0
1.1
1.0
mmol/l
0.97
90
388
227
1446
2.25
14.71
12.8
9.6
1.2
1.2
inr
0.35
54
423
184
1101
2.20
13.63
7.5
5.5
—
—
—
0
0
235
1587
2.11
12.33
11.3
5.6
1.2
1.2
mmol/l
0.01
209
1433
249
1725
2.10
12.12
12.1
6.6
1.2
1.2
mmol/l
0.04
208
1458
242
1662
2.09
12.02
7.6
5.6
0.6
0.6
e9/l
0.23
206
1442
242
1675
2.06
11.61
7.6
5.6
0.0
0.0
e9/l
0.20
206
1456
277
2019
2.11
11.50
9.8
4.6
6.7
6.7
mmol/l
0.02
257
1882
244
1701
2.05
11.39
7.6
5.6
1.9
1.9
e9/l
0.01
213
1506
224
1515
2.04
11.37
7.9
5.7
0.7
0.7
%
0.94
208
1411
267
1932
2.07
11.14
11.5
9.5
4.4
4.1
e9/l
1.17
232
1705
245
1726
2.02
10.93
8.3
5.8
0.2
0.2
e9/l
1.11
214
1525
231
1600
2.00
10.75
8.0
5.8
26.2
27.2
%
0.76
212
1485
66
279
2.62
10.53
12.6
8.5
9.3
10.0
mmol/l
0.34
59
268
226
1570
1.96
10.25
8.0
5.6
2.6
2.8
%
0.47
210
1458
226
1575
1.95
10.10
8.2
5.9
8.6
8.7
%
0.11
209
1475
102
537
2.19
9.92
3.5
2.4
10.7
13.3
umol/l
3.42
96
494
166
1057
1.95
9.56
4.3
2.4
—
—
—
0
0
206
1416
1.90
9.36
4.2
2.6
115.2
129.6
ug/l
0.40
190
1291
224
1586
1.89
9.25
8.0
5.6
58.7
57.7
%
0.57
206
1484
64
284
2.48
9.20
17.3
7.8
—
—
—
0
0
36
117
3.27
9.18
1.8
1.6
—
—
—
0
0
138
836
1.97
9.11
1.8
1.5
21.5
21.1
nmol/l
0.11
124
700
61
269
2.49
8.87
3.0
3.2
197.5
207.7
ng/l
0.08
55
241
219
1564
1.85
8.57
5.3
4.1
—
—
—
0
0
204
1429
1.84
8.46
2.4
2.0
95.8
94.2
pmol/l
0.19
120
747
77
386
2.22
8.35
1.5
1.3
—
—
—
0
0
356
3013
2.26
8.03
29.6
15.8
38.8
39.8
%
1.22
229
2103
295
2341
1.89
7.94
4.9
4.2
—
—
—
0
0
78
403
2.15
7.83
16.6
6.7
11.4
12.1
kpa
0.65
72
385
78
403
2.15
7.83
16.7
6.7
5.1
5.1
kpa
0.11
72
385
46
188
2.63
7.81
14.9
8.7
—
—
—
0
0
49
208
2.54
7.70
1.1
1.3
—
—
—
0
0
77
400
2.14
7.61
16.8
6.8
1.3
1.1
mmol/l
0.15
64
316
112
669
1.92
7.51
4.5
3.8
645.6
279.0
ng/l
0.31
88
534
147
971
1.79
7.10
6.3
4.2
—
—
—
0
0
84
468
2.00
6.84
3.8
2.4
18.5
22.7
%
2.48
71
402
152
1025
1.76
6.78
2.8
3.1
—
—
—
0
0
73
389
2.06
6.71
3.2
3.1
6.8
9.2
umol/l
0.73
61
342
155
1057
1.74
6.62
6.3
3.9
7.4
7.4
ph
0.37
29
204
91
529
1.92
6.54
2.7
1.9
—
—
—
0
0
306
2530
1.79
6.36
5.1
4.1
14.9
12.0
mm/h
1.97
272
2313
379
3371
2.40
6.30
26.0
14.7
22.5
24.4
mg/l
0.65
314
2650
51
243
2.25
6.21
4.6
3.6
112.0
83.1
ng/l
1.02
43
213
79
445
1.96
6.21
16.0
6.2
104.1
104.0
mmol/l
0.06
79
431
167
1180
1.69
6.17
3.7
3.5
2.3
2.3
mmol/l
0.31
142
1024
77
431
1.97
6.16
1.2
1.3
301.2
479.6
titre
0.81
17
99
68
365
2.03
6.11
2.6
2.2
138.5
132.7
ug/g
0.06
48
286
72
402
1.96
5.79
2.8
4.4
7.4
41.2
ug/l
0.99
64
338
22
71
3.22
5.70
1.2
1.2
—
—
—
0
0
16
42
3.92
5.59
1.1
1.4
—
—
—
0
0
184
1363
1.63
5.50
2.7
2.1
—
—
—
0
0
35
149
2.47
5.48
1.9
1.8
1.3
1.5
g/l
0.74
29
127
75
438
1.87
5.25
1.4
1.3
—
—
—
0
0
103
668
1.72
5.07
2.0
1.7
1159.3
1202.1
nmol/l
0.14
74
495
135
942
1.64
5.04
3.7
3.0
—
—
—
0
0
350
3084
1.85
5.03
5.7
4.6
1.9
2.3
mu/l
0.53
322
2770
383
3496
2.20
4.72
31.0
17.1
139.4
139.6
mmol/l
0.98
375
3400
28
117
2.49
4.58
2.0
2.0
412.2
308.1
ug/l
0.16
28
110
100
660
1.68
4.58
3.3
3.1
2.5
2.4
mmol/l
0.33
84
578
383
3504
2.17
4.55
31.2
17.3
4.0
4.0
mmol/l
0.70
375
3407
136
973
1.59
4.50
3.8
3.1
0.4
0.5
e6/l
0.65
101
727
209
1649
1.54
4.47
3.7
3.6
0.0
0.0
estimate
0.00
32
326
163
1220
1.55
4.42
4.3
3.7
67.7
70.7
e6/l
0.04
114
877
286
2431
1.56
4.26
4.5
4.0
—
—
—
0
0
55
311
1.89
4.24
1.5
1.4
—
—
—
0
0
119
842
1.58
4.07
7.5
6.8
—
—
—
0
0
207
1655
1.50
4.01
5.1
4.9
0.0
0.0
estimate
0.00
33
324
318
2786
1.60
4.00
31.2
18.3
14.2
13.7
%
3.06
313
2745
54
311
1.85
3.94
4.4
4.2
1.8
1.9
mmol/l
0.11
47
242
23
95
2.50
3.87
2.5
3.2
—
—
—
0
0
67
414
1.74
3.87
2.1
1.6
—
—
—
0
0
208
1675
1.48
3.83
3.7
3.7
0.0
0.0
estimate
0.50
31
313
66
410
1.72
3.74
2.7
2.5
1.7
1.8
%
0.42
59
367
35
177
2.07
3.71
2.6
2.5
—
—
—
0
0
292
2527
1.52
3.71
4.5
3.8
14.5
14.9
pmol/l
1.90
272
2252
190
1510
1.48
3.70
13.2
9.7
0.0
0.0
e9/l
0.61
154
1250
44
248
1.87
3.44
1.4
1.4
—
—
—
0
0
123
909
1.50
3.38
2.7
2.7
3647.7
6293.2
umol/l
0.32
105
781
8
14
5.80
3.35
1.1
1.5
121.8
126.1
nmol/l
—
8
14
51
304
1.77
3.34
1.6
1.5
—
—
—
0
0
105
755
1.52
3.27
1.8
1.8
1.0
1.3
mg/l
0.95
79
598
139
1063
1.46
3.20
3.8
3.2
96.7
49.3
e6/l
0.31
107
815
66
429
1.64
3.16
1.8
1.4
—
—
—
0
0
376
3494
1.79
3.13
23.3
13.9
—
—
—
0
0
18
74
2.50
3.09
6.9
3.4
—
—
—
0
0
102
740
1.50
3.03
2.9
2.6
6.2
4.5
e6/l
0.46
91
647
170
1361
1.42
3.02
4.1
3.8
35.0
38.0
ng/l
0.14
111
983
136
1049
1.44
2.95
4.7
3.9
—
—
—
0
0
138
1068
1.44
2.94
2.7
2.0
182.9
197.9
u/l
0.18
133
996
90
641
1.52
2.91
1.3
1.4
2.6
2.6
g/l
0.01
49
385
23
109
2.18
2.90
1.1
1.2
—
—
—
0
0
7
13
5.46
2.88
2.7
3.5
—
—
—
0
0
97
704
1.49
2.87
1.4
1.2
0.5
1.3
u/ml
2.55
20
192
18
77
2.40
2.86
7.2
3.6
3.0
2.9
mmol/l
0.05
12
50
383
3600
1.81
2.75
15.5
10.6
25.4
25.8
u/l
0.24
368
3456
26
135
1.99
2.61
1.3
1.3
—
—
—
0
0
17
74
2.35
2.61
3.5
3.4
—
—
—
0
0
47
295
1.67
2.59
3.1
2.6
66.4
68.7
e9/l
0.15
30
235
38
225
1.76
2.57
1.3
1.2
—
—
—
0
0
392
3721
1.93
2.57
37.8
21.6
30.2
30.3
pg
0.44
386
3663
392
3721
1.93
2.57
38.0
21.7
254.9
246.5
e9/l
1.41
383
3618
392
3721
1.93
2.57
37.9
21.6
91.3
91.2
fl
0.15
386
3663
12
44
2.78
2.57
1.2
1.2
—
—
—
0
0
392
3722
1.92
2.55
38.0
21.7
4.4
4.5
e12/l
3.40
379
3610
392
3723
1.92
2.53
38.1
21.7
7.0
6.7
e9/l
2.07
380
3614
392
3724
1.91
2.51
38.3
21.8
130.9
135.2
g/l
5.83
383
3662
94
697
1.45
2.48
2.8
2.8
530.6
562.1
mosm/kgh2o
0.76
85
585
137
1088
1.39
2.45
3.0
3.0
1477.1
1422.0
ng/l
0.07
110
922
356
3311
1.52
2.36
5.5
4.7
6.0
6.0
mmol/l
0.08
327
2998
77
556
1.47
2.32
1.3
1.3
31.1
34.7
iu/ml
0.09
31
183
95
722
1.41
2.18
1.8
1.7
479.5
9965472.8
pmol/l
0.50
76
572
97
744
1.40
2.11
3.8
4.6
—
—
—
0
0
98
753
1.39
2.11
3.9
3.6
—
—
—
0
0
22
118
1.91
2.06
1.2
1.0
—
—
—
0
0
15
70
2.19
2.00
3.1
2.7
14.0
15.9
%
—
8
35
44
291
1.57
2.00
8.0
4.2
1.2
1.2
mmol/l
0.28
38
254
132
1072
1.34
2.00
3.1
3.1
7.4
7.4
mmol/l
0.06
115
884
117
938
1.34
1.92
3.0
3.3
—
—
—
0
0
62
446
1.46
1.91
2.1
1.7
—
—
—
0
0
9
34
2.68
1.87
1.1
1.1
—
—
—
0
0
126
1026
1.33
1.86
3.2
3.3
1159.5
184.8
mg/l
0.65
79
657
6
17
3.56
1.84
8.2
6.2
—
—
—
0
0
6
17
3.56
1.84
2.2
2.9
21.5
18.4
mu/l
—
6
17
6
17
3.56
1.84
2.0
1.6
—
—
—
0
0
14
66
2.16
1.84
2.6
2.7
—
—
—
0
0
11
48
2.33
1.72
1.1
2.8
—
—
—
0
0
47
329
1.48
1.68
2.3
1.5
—
—
—
0
0
130
1082
1.29
1.61
3.9
4.1
5.7
8.8
mg/mmol
0.88
82
668
35
232
1.56
1.60
10.4
4.3
—
—
—
0
0
8
32
2.53
1.60
1.1
1.3
—
—
nmol/l
—
0
0
106
860
1.31
1.59
1.3
1.4
—
—
—
0
0
11
50
2.23
1.58
2.7
2.4
5.2
4.9
e9/l
0.19
11
50
35
235
1.53
1.53
1.4
2.4
—
—
—
0
0
5
15
3.36
1.52
1.2
1.1
64.4
25.6
%
—
5
10
7
27
2.62
1.52
1.3
3.4
10.5
11.3
%
—
7
27
9
38
2.40
1.46
1.9
1.3
1746.8
1587.1
e6/l
—
9
24
12
59
2.06
1.45
1.3
1.6
—
—
—
0
0
11
53
2.10
1.39
2.8
2.8
64.6
58.9
%
1.25
11
53
28
184
1.56
1.36
1.3
1.3
—
—
—
0
0
68
532
1.33
1.31
1.4
1.3
31.6
11.1
u/ml
0.73
29
219
5
18
2.80
1.29
1.4
1.2
—
—
—
0
0
5
18
2.80
1.29
1.0
1.3
0.4
1.0
%
—
5
11
110
923
1.26
1.26
1.8
1.6
1.3
1.4
mmol/l
0.44
95
770
8
36
2.25
1.25
1.1
1.3
—
—
—
0
0
6
25
2.42
1.25
2.5
1.8
0.2
0.2
e9/l
—
6
19
14
78
1.82
1.22
1.6
1.5
3.2
6.1
iu/l
—
5
23
14
78
1.82
1.22
1.1
4.2
—
—
—
0
0
334
3164
1.28
1.22
6.5
6.0
40.0
40.2
mmol/mol
0.12
299
2920
5
19
2.65
1.22
1.2
1.4
23.8
70.5
%
—
5
11
10
184
0.53
1.16
1.7
1.4
—
—
—
0
0
7
31
2.28
1.11
1.9
1.2
—
—
—
0
0
42
316
1.37
1.06
2.0
2.5
4.9
8.3
ug/l
1.44
37
278
31
222
1.43
1.04
4.7
3.4
7.4
7.4
ph
—
5
26
9
47
1.93
1.02
2.3
1.4
—
—
—
0
0
45
345
1.34
1.02
1.6
1.6
—
—
—
0
0
9
48
1.89
1.01
1.3
1.6
—
—
—
0
0
9
48
1.89
1.01
1.3
1.6
—
—
—
0
0
9
48
1.89
1.01
1.3
1.6
—
—
—
0
0
9
48
1.89
1.01
1.3
1.6
—
—
—
0
0
336
3207
1.25
1.00
4.1
4.1
1.3
1.3
mmol/l
0.26
301
2903
7
35
2.02
1.00
1.1
1.1
—
—
—
0
0
7
35
2.02
1.00
1.9
1.5
279.9
274.6
mosm/kgh2o
—
7
25
7
36
1.96
0.97
1.4
1.3
152.0
333.9
pmol/l
—
7
29
87
733
1.24
0.96
3.9
4.1
1.0
1.0
kg/l
2.06
12
100
18
117
1.56
0.95
3.0
3.6
0.2
0.2
g/l
—
7
42
39
296
1.35
0.95
5.0
3.7
—
—
—
0
0
48
376
1.31
0.95
2.2
1.5
—
—
—
0
0
44
344
1.31
0.89
5.6
4.1
—
—
—
0
0
8
43
1.88
0.87
1.1
1.2
—
—
—
0
0
6
30
2.01
0.87
1.0
1.2
—
—
—
0
0
347
3338
1.24
0.87
4.6
4.6
4.5
4.6
mmol/l
1.12
317
3051
8
44
1.83
0.86
2.1
1.9
86.3
89.6
%
—
8
44
20
137
1.48
0.85
7.3
3.8
—
—
—
0
0
8
45
1.79
0.84
1.3
1.6
—
—
—
0
0
8
45
1.79
0.84
1.4
1.3
—
75.1
—
0
5
27
197
1.40
0.84
1.8
1.5
—
—
—
0
0
103
1172
0.84
0.81
3.0
3.0
—
—
—
0
0
344
3314
1.22
0.80
4.6
4.5
1.4
1.5
mmol/l
2.32
310
3017
352
3404
1.22
0.75
5.3
5.1
2.7
2.7
mmol/l
0.47
321
3094
9
54
1.68
0.75
2.1
1.6
—
—
—
0
0
11
68
1.63
0.72
4.5
3.0
0.8
0.8
nmol/l
0.15
11
56
5
26
1.93
0.71
2.2
1.8
558.6
505.0
e6/l
—
5
19
7
41
1.72
0.70
1.7
1.4
—
—
—
0
0
35
276
1.29
0.69
2.7
4.3
0.0
0.2
%
—
8
86
7
43
1.64
0.67
3.7
1.3
—
—
—
0
0
13
190
0.67
0.67
2.0
2.9
0.1
0.1
e6/l
0.07
13
185
23
172
1.36
0.65
5.8
2.8
21.1
37.3
u/ml
1.14
23
166
33
261
1.29
0.65
2.8
4.3
0.0
0.1
%
—
8
73
5
29
1.73
0.64
1.0
1.4
—
—
—
0
0
5
30
1.67
0.61
1.2
1.1
—
—
—
0
0
37
300
1.26
0.60
2.6
4.1
0.4
1.0
%
—
8
97
0
20
0.00
0.60
0.0
1.3
—
—
—
0
0
11
72
1.54
0.59
1.1
1.7
—
—
—
0
0
22
168
1.33
0.56
2.0
3.6
—
—
—
0
0
6
37
1.63
0.55
1.2
1.2
—
—
—
0
0
10
66
1.53
0.53
1.8
1.2
—
—
—
0
0
6
96
0.62
0.52
1.2
1.3
—
—
—
0
0
28
224
1.27
0.52
2.8
2.3
3.6
4.0
e9/l
0.38
17
163
7
108
0.64
0.49
1.0
1.1
—
—
—
0
0
7
109
0.64
0.49
7.6
9.9
—
—
—
0
0
34
282
1.22
0.48
4.0
3.5
—
—
—
0
0
7
49
1.44
0.46
1.1
1.5
—
—
—
0
0
12
87
1.39
0.42
1.3
1.3
—
2.5
—
0
13
10
70
1.44
0.42
9.0
3.2
—
—
—
0
0
8
58
1.39
0.41
1.8
1.4
—
—
—
0
0
5
34
1.48
0.40
1.8
3.1
—
—
—
0
0
5
34
1.48
0.40
1.4
1.5
—
—
—
0
0
10
71
1.42
0.39
1.7
1.3
—
—
—
0
0
5
35
1.43
0.39
1.4
2.8
—
—
—
0
0
5
36
1.39
0.38
1.4
1.1
—
—
—
0
0
5
36
1.39
0.38
1.4
1.1
—
—
—
0
0
5
36
1.39
0.38
1.4
1.1
—
—
—
0
0
9
69
1.31
0.37
1.3
2.3
—
—
—
0
0
20
162
1.25
0.36
5.7
3.3
—
—
—
0
0
65
718
0.89
0.36
2.7
2.9
0.5
0.8
ug/l
2.44
45
473
5
76
0.65
0.36
1.8
1.8
—
—
—
0
0
5
76
0.65
0.36
1.2
1.3
—
259.2
—
0
35
6
42
1.43
0.35
1.2
4.4
—
—
—
0
0
6
42
1.43
0.35
1.2
1.2
—
—
—
0
0
6
45
1.34
0.34
2.7
2.5
—
—
—
0
0
6
46
1.31
0.33
1.0
1.0
—
—
—
0
0
28
240
1.18
0.31
1.1
1.4
—
—
—
0
0
16
129
1.25
0.30
1.3
1.9
—
—
—
0
0
12
94
1.28
0.28
1.2
1.1
—
—
—
0
0
10
76
1.32
0.28
1.7
1.3
—
—
—
0
0
22
187
1.19
0.27
1.8
1.6
—
—
—
0
0
10
77
1.31
0.26
1.7
1.3
—
—
—
0
0
10
77
1.31
0.26
1.7
1.3
—
—
—
0
0
10
78
1.29
0.24
1.8
1.3
—
—
—
0
0
10
79
1.27
0.22
1.6
1.1
9.8
11.3
u/l
—
10
62
0
11
0.00
0.21
0.0
1.3
—
—
—
0
0
0
10
0.00
0.21
0.0
1.1
—
85.7
—
0
10
0
12
0.00
0.21
0.0
1.1
—
—
—
0
0
19
219
0.86
0.21
1.7
3.1
—
—
—
0
0
0
13
0.00
0.21
0.0
1.2
—
—
—
0
0
0
14
0.00
0.20
0.0
4.7
—
48.9
—
0
14
6
51
1.18
0.19
3.2
1.8
31.0
32.9
pg
—
6
51
6
52
1.16
0.19
1.3
4.0
0.5
1.8
%
—
6
44
29
262
1.11
0.18
1.2
1.4
—
—
—
0
0
29
263
1.11
0.17
3.0
4.0
0.3
0.4
%
—
7
63
118
1220
0.95
0.14
4.7
4.9
1.4
2.7
ug/l
3.16
103
1080
8
96
0.83
0.14
2.3
4.3
—
—
—
0
0
13
149
0.87
0.14
2.9
2.9
—
—
—
0
0
15
135
1.12
0.10
1.3
1.7
—
—
—
0
0
7
64
1.10
0.08
1.7
1.3
—
—
—
0
0
9
87
1.04
0.07
1.7
1.2
—
—
—
0
0
94
923
1.02
0.05
4.6
3.9
0.0
0.0
estimate
0.00
30
318
10
92
1.09
0.03
2.6
2.7
31.0
115.6
ug/min
—
5
56
14
139
1.01
0.00
1.0
1.1
—
—
—
0
0
20
203
0.98
0.00
1.3
1.2
174.8
133.1
iu/ml
—
6
86
0
7
0.00
0.00
0.0
1.6
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.8
—
—
—
0
0
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
0
7
0.00
0.00
0.0
1.7
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.4
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
4.6
—
4.3
—
0
5
0
5
0.00
0.00
0.0
1.0
—
7.6
—
0
5
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
8
83
0.96
0.00
1.1
1.4
1.6
15.5
e6/l
—
8
67
0
5
0.00
0.00
0.0
2.4
—
—
—
0
0
8
82
0.98
0.00
1.1
1.4
3.8
3.8
mmol/l
—
8
77
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
9
0.00
0.00
0.0
1.8
—
1.2
—
0
9
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
20.2
—
0
5
0
6
0.00
0.00
0.0
1.3
—
1.9
—
0
6
8
83
0.96
0.00
1.1
1.5
8.0
1443.3
e6/l
—
8
69
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
2.4
—
—
—
0
0
6
68
0.88
0.00
1.2
1.1
123.9
37.5
u/l
—
6
60
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
0
6
0.00
0.00
0.0
3.5
—
—
—
0
0
7
72
0.97
0.00
1.1
1.4
—
—
—
0
0
0
5
0.00
0.00
0.0
2.6
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0

Mortality – FinRegistry

↥

Association

Association between endpoint CD2_BENIGN_OESOPHAGUS and mortality.

Females

Parameter HR [95% CI] p-value
CD2_BENIGN_OESOPHAGUS 1.743 [1.42, 2.14] < 0.001
Birth year 0.998 [0.99, 1.01] 0.605

During the follow-up period (1.1.1998 — 31.12.2019), 220 out of 904 females with CD2_BENIGN_OESOPHAGUS died.

Males

Parameter HR [95% CI] p-value
CD2_BENIGN_OESOPHAGUS 2.397 [1.96, 2.94] < 0.001
Birth year 0.986 [0.98, 1.0] 0.005

During the follow-up period (1.1.1998 — 31.12.2019), 354 out of 951 males with CD2_BENIGN_OESOPHAGUS died.

Mortality risk

Mortality risk for people of age

years, who have CD2_BENIGN_OESOPHAGUS.

N-year risk Females Males
1 0.182% 0.547%
5 1.21% 2.914%
10 2.852% 6.638%
15 5.388% 13.23%
20 9.566% 20.951%

Relationships between endpoints

↥

Index endpoint: CD2_BENIGN_OESOPHAGUS – Benign neoplasm: Oesophagus

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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