Unspecified protein-energy malnutrition

E4_PROTMALNAS

protein energy malnutrition: A nutritional deficit that is caused by inadequate protein or calorie intake.

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Endpoint definition

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

519972

1. Apply sex-specific rule

None

519972

2. Check conditions

None

519972

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 E46
  • Hospital discharge: ICD-9 263[8-9]
  • Hospital discharge: ICD-8 26799
  • Cause of death: ICD-10 E46
  • Cause of death: ICD-9 263[8-9]
  • Cause of death: ICD-8 26799

2 out of 7 registries used, show all original rules.

209

4. Check minimum number of events

None

209

5. Include endpoints

None

209

6. Filter based on genotype QC (FinnGen only)

198

Control definitions (FinnGen only)

Control exclude
E4_MALNUTRITION

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
E40-E46
Name in latin
Malnutritio non specificata ex deficientia proteino-energetica

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 2837 1661 1166
Only index persons 2520 1510 1010
Unadjusted period prevalence (%)
Whole population 0.04 0.05 0.03
Only index persons 0.05 0.06 0.04
Median age at first event (years)
Whole population 75.04 77.51 71.59
Only index persons 75.85 78.14 72.43

-FinnGen-

Key figures

All Female Male
Number of individuals 198 110 88
Unadjusted period prevalence (%) 0.04 0.04 0.04
Median age at first event (years) 72.91 69.94 76.63

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
209
Matched controls
2090
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
E46
ICD-10 Finland
Unspecified protein-energy malnutrition
+∞
285.6
203
*
E86
ICD-10 Finland
Volume depletion
18.1
40.9
35
23
Z50.9
ICD-10 Finland
Care involving use of rehabilitation procedure, unspecified
9.5
21.5
27
32
A28
ICPC
Limited function/disability NOS
3.9
19.2
80
287
R63.4
ICD-10 Finland
Abnormal weight loss
7.6
17.9
27
40
E87.6
ICD-10 Finland
Hypokalaemia
7.6
16.1
24
35
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
3.5
16.0
75
286
SPAT1229
SPAT
Assessment of need for aid
5.0
15.3
37
87
D50.9
ICD-10 Finland
Iron deficiency anaemia, unspecified
5.0
15.2
36
83
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
3.1
14.3
105
517
112
Kela drug reimbursment
Severe psychotic and other severe mental disorders
5.4
14.0
30
63
SPAT1222
SPAT
Counselling/guidance promoting independent living
3.4
13.6
63
236
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.9
12.7
89
421
L28
ICPC
Limited function/disability (L)
3.2
12.7
68
277
Z71.3
ICD-10 Finland
Dietary counselling and surveillance
6.4
12.5
22
38
J18.9
ICD-10 Finland
Pneumonia, unspecified
2.9
12.4
89
426
N17.9
ICD-10 Finland
Acute renal failure, unspecified
5.6
12.1
24
47
JN3AD
NOMESCO Finland
Abdominal CT examination
3.9
10.9
36
107
D64.9
ICD-10 Finland
Anaemia, unspecified
3.4
10.4
44
154
AA1AD
NOMESCO Finland
CT of head and brain
2.7
10.4
80
391
WYA30
NOMESCO Finland
Treatment of a patient needing special arrangements
4.2
10.2
29
77
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
4.4
9.6
26
66
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
3.8
9.5
32
96
Z51.5
ICD-10 Finland
Palliative care
3.8
9.5
31
91
I95.1
ICD-10 Finland
Orthostatic hypotension
4.7
9.4
23
54
Z25.1
ICD-10 Finland
Need for immunization against influenza
5.0
9.3
21
46
ZXD05
NOMESCO Finland
Urgent procedure
2.6
9.3
78
394
R53
ICD-10 Finland
Malaise and fatigue
2.5
9.1
78
397
JN4AD
NOMESCO Finland
Body CT examination
3.7
9.0
31
94
Z46.8
ICD-10 Finland
Fitting and adjustment of other specified devices
7.8
9.0
20
28
A49.9
ICD-10 Finland
Bacterial infection, unspecified
3.2
8.9
41
150
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
3.1
8.5
40
148
R5110, ,
SPAT
3.9
8.4
26
73
C03CA01
ATC
furosemide; systemic
2.4
8.4
102
603
N05AX08
ATC
risperidone; systemic
3.1
8.2
38
139
SPAT1230
SPAT
Aid fitting and borrowing and monitoring of use
2.8
8.2
50
214
JDB10
NOMESCO Finland
Percutaneous gastrostomy
18.1
8.2
12
7
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
2.7
8.0
51
223
A46
ICD-10 Finland
Erysipelas
2.8
7.5
43
177
EBA15
NOMESCO Finland
Extraction of multiple teeth
7.3
7.5
17
25
F03
ICD-10 Finland
Unspecified dementia
4.0
7.4
22
60
SPAT1216
SPAT
Assessment of functional ability
2.6
7.4
53
245
S97
ICPC
Chronic ulcer skin
3.6
7.4
26
80
EB1CI
NOMESCO Finland
Cone beam imaging of teeth and jaws (3-4 quarters)
+∞
7.3
7
*
SPAT1301
SPAT
No procedures
2.3
7.3
82
463
K59.09
ICD-10 Finland
Constipation, unspecified
3.5
7.3
26
81
504
Kela drug reimbursment
Conditions requiring daily forced enteral nutrition
10.6
7.1
13
13
SPAT1254
SPAT
Administration of medicine
2.6
7.0
48
217
N02AA05
ATC
oxycodone; systemic
2.4
6.9
57
280
L89
ICD-10 Finland
Decubitus ulcer and pressure area
8.7
6.9
14
17
R4110
NOMESCO Finland
Physiotherapy
2.2
6.8
74
410
B03BA03
ATC
hydroxocobalamin; parenteral
3.5
6.7
24
75
F10.1
ICD-10 Finland
Mental and behavioural disorders due to use of alcohol, Harmful use
3.9
6.7
20
55
WX302
NOMESCO Finland
Thoracal epidural anesthesy
5.7
6.6
18
34
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
2.4
6.6
54
264
F32.9
ICD-10 Finland
Depressive episode, unspecified
2.9
6.5
32
121
Z01.8
ICD-10 Finland
Other specified special examinations
2.4
6.5
52
252
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
2.5
6.4
48
225
W19
ICD-10 Finland
Unspecified fall
2.8
6.4
34
134
SPAT1255
SPAT
Intravenous administration of medicine
3.6
6.2
21
63
WX892
NOMESCO Finland
Monitored bed care
3.4
6.1
22
69
KH1AE
NOMESCO Finland
Urinary tract ultrasound examination
3.5
6.0
21
64
Z2446
NOMESCO Finland
Social worker
3.3
6.0
24
80
JN4CD
NOMESCO Finland
Very extensive body CT
5.3
6.0
17
34
I50.9
ICD-10 Finland
Heart failure, unspecified
2.3
6.0
55
282

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
93
263
5.57
32.76
7.7
4.3
0.77
0.81
mmol/l
1.97
88
244
157
716
5.79
30.03
8.8
4.7
29.69
35.10
g/l
15.66
152
663
79
232
4.87
25.78
3.1
2.4
17.72
22.30
%
1.74
69
192
110
452
4.03
22.21
3.0
2.4
3.54
3.06
mg/l
0.60
101
381
115
498
3.91
21.28
3.8
2.4
53.22
55.61
u/l
0.34
109
462
155
838
4.29
20.29
11.4
7.4
1.20
1.22
mmol/l
2.20
129
711
56
150
4.73
20.02
3.2
2.9
70.79
64.80
e9/l
0.68
47
119
147
773
4.04
19.89
8.1
7.0
1.20
1.22
mmol/l
2.28
138
695
134
665
3.83
19.74
3.5
2.5
72.98
78.51
nmol/l
1.23
127
578
90
345
3.83
19.66
2.4
1.8
1301.69
1159.60
nmol/l
0.75
69
255
107
479
3.53
18.10
7.3
4.3
—
—
—
0
0
66
216
4.00
17.93
2.7
2.9
1.93
1.70
%
1.00
61
188
118
577
3.40
17.02
4.6
3.1
2.29
2.36
mmol/l
2.89
109
503
130
678
3.43
16.78
2.8
2.0
78.44
95.88
pmol/l
3.97
80
322
88
374
3.34
15.76
5.4
3.0
520.52
537.45
mosm/kgh2o
0.33
79
318
65
235
3.56
14.97
3.2
2.2
—
—
—
0
0
57
194
3.66
14.33
2.5
1.8
—
—
—
0
0
137
783
3.18
14.30
27.3
16.4
1.30
1.29
inr
0.03
46
221
124
678
3.04
13.87
3.8
2.8
218.43
116.16
ug/l
2.00
115
603
90
427
2.95
12.82
5.7
3.9
—
—
—
0
0
43
130
3.91
12.74
3.5
5.3
7.44
7.40
ph
—
6
15
113
611
2.85
12.51
8.4
4.2
118.05
86.36
e6/l
0.30
91
438
22
39
6.19
12.23
1.4
1.5
210.46
284.32
ug/g
0.84
13
25
92
451
2.86
12.21
7.0
4.3
—
—
—
0
0
104
545
2.81
12.13
5.5
3.4
447.50
168.35
e6/l
0.31
89
416
90
440
2.84
11.96
5.5
4.7
0.00
0.00
estimate
-0.00
30
142
86
416
2.81
11.59
2.2
1.6
19.96
22.04
nmol/l
0.50
78
345
130
784
2.74
11.22
7.3
5.8
0.00
0.00
estimate
-0.00
32
146
113
637
2.68
11.16
6.4
4.4
48.67
50.23
ng/l
0.04
100
457
125
743
2.70
11.05
11.6
6.4
—
—
—
0
0
129
790
2.65
10.56
5.6
4.3
0.00
0.00
estimate
-0.00
31
141
128
782
2.64
10.51
5.4
4.3
0.00
0.00
estimate
-0.00
34
159
37
115
3.69
10.45
1.7
2.4
—
—
—
0
0
103
573
2.57
10.20
5.6
3.5
—
—
—
0
0
36
113
3.64
10.01
4.6
4.3
0.00
0.24
%
0.57
12
37
131
822
2.59
9.98
10.1
6.1
0.16
0.19
e9/l
1.11
122
716
93
498
2.56
9.91
4.2
2.5
—
—
—
0
0
128
797
2.56
9.87
10.1
5.9
0.04
0.04
e9/l
0.42
120
687
123
752
2.54
9.86
10.3
6.3
8.60
8.65
%
0.05
117
702
62
272
2.82
9.84
6.0
3.2
5.81
2.89
e6/l
1.16
51
145
37
120
3.53
9.79
4.5
4.2
0.08
0.19
%
0.49
13
43
122
746
2.53
9.73
10.2
5.9
2.20
2.84
%
2.70
116
693
127
796
2.52
9.54
10.7
5.9
0.61
0.57
e9/l
0.77
120
685
40
139
3.32
9.49
4.4
3.4
103.21
73.00
ng/l
0.77
33
123
92
499
2.51
9.44
3.7
2.1
213.13
267.06
u/l
0.30
87
470
74
364
2.60
9.31
1.9
1.8
450.76
482.98
pmol/l
0.35
55
297
124
775
2.48
9.28
11.1
6.0
21.41
27.92
%
8.29
118
723
128
820
2.45
8.95
10.5
5.9
1.46
1.88
e9/l
4.70
120
727
51
212
2.86
8.87
8.5
8.2
102.02
104.18
mmol/l
2.09
51
212
118
732
2.41
8.83
10.5
5.9
0.53
0.65
%
1.76
111
676
18
22
8.84
8.78
2.3
2.0
—
—
—
0
0
37
129
3.27
8.71
4.6
4.1
0.62
1.08
%
0.66
13
53
45
180
2.91
8.36
6.0
4.5
1.68
2.12
mmol/l
0.25
38
136
120
762
2.35
8.35
10.3
5.9
62.61
57.00
%
4.25
114
712
137
926
2.39
8.18
17.9
9.3
4.61
4.14
e9/l
1.36
130
793
49
209
2.76
8.07
1.5
1.2
—
—
—
0
0
66
336
2.41
7.49
4.2
3.1
2.47
2.46
mmol/l
0.21
60
282
19
46
4.44
7.45
1.3
3.8
58.49
26.16
mg/l
0.87
14
35
19
46
4.44
7.45
1.3
3.8
56.67
84.72
mg/l
0.34
14
35
156
1147
2.42
7.23
5.5
4.2
17.18
13.02
mm/h
2.17
149
1028
31
109
3.17
7.16
4.7
4.2
0.75
0.74
%
0.01
12
40
68
359
2.33
7.06
4.5
4.9
1.02
1.01
kg/l
—
8
53
18
32
6.05
6.94
1.2
4.5
—
—
—
0
0
149
1087
2.29
6.84
6.0
4.6
—
—
—
0
0
14
18
8.25
6.73
2.4
1.8
32.07
31.72
pg
0.06
14
18
19
52
3.92
6.36
5.1
4.2
—
—
—
0
0
86
519
2.12
6.30
7.0
3.8
7.40
7.40
ph
0.22
27
90
26
90
3.16
6.14
4.4
5.2
—
—
—
0
0
16
40
4.25
6.02
3.7
3.1
—
—
—
0
0
60
325
2.19
5.71
2.0
1.5
2.79
2.43
g/l
0.60
46
180
13
21
6.52
5.48
1.5
1.4
—
—
—
0
0
28
110
2.78
5.31
1.3
1.3
—
—
—
0
0
148
1133
2.05
5.24
4.9
3.9
15.29
15.01
pmol/l
0.57
137
989
12
20
6.29
4.99
1.8
1.2
273.92
272.31
mosm/kgh2o
0.08
12
13
12
21
5.99
4.83
1.3
1.7
—
—
—
0
0
8
8
10.34
4.56
18.2
14.8
1114.63
1309.25
nmol/l
—
8
8
102
712
1.84
4.52
23.5
10.4
0.00
0.02
e9/l
0.58
95
571
15
37
4.29
4.51
4.3
3.0
2.58
2.45
mmol/l
—
9
21
182
1543
2.39
4.45
41.4
16.2
31.16
25.18
mg/l
1.38
168
1225
9
12
7.78
4.40
1.3
1.1
—
—
—
0
0
12
24
5.24
4.39
1.9
1.5
—
—
—
0
0
168
1384
2.09
4.37
5.9
4.7
2.09
1.96
mu/l
0.49
158
1220
7
6
12.01
4.30
2.9
1.7
—
—
—
0
0
15
39
4.06
4.29
1.2
1.3
—
—
—
0
0
27
118
2.48
4.15
3.0
8.1
—
—
—
0
0
7
7
10.29
4.04
2.0
1.1
102.71
115.71
nmol/l
—
7
7
14
43
3.42
3.98
2.7
2.6
16.77
15.55
%
—
9
24
39
204
2.12
3.97
4.5
9.5
1.96
1.40
mmol/l
0.24
27
152
13
33
4.13
3.87
1.1
1.5
—
—
—
0
0
11
24
4.78
3.80
4.5
2.8
4.61
4.85
e9/l
0.08
11
24
6
5
12.30
3.78
1.3
1.2
—
—
—
0
0
6
5
12.30
3.78
2.8
1.0
93.33
54.00
nmol/l
—
6
5
31
151
2.24
3.75
1.9
1.4
—
—
—
0
0
10
20
5.19
3.74
1.2
1.0
—
—
—
0
0
11
25
4.58
3.68
5.5
2.8
62.73
60.24
%
0.25
11
25
28
132
2.29
3.65
7.5
4.2
—
—
—
0
0
17
63
2.85
3.59
1.9
4.0
0.18
0.34
g/l
—
7
26
8
13
6.35
3.53
1.3
1.2
—
—
—
0
0
16
58
2.90
3.51
7.4
6.5
1.51
1.50
mg/l
0.02
16
50
65
425
1.77
3.39
14.2
7.2
—
—
—
0
0
13
38
3.58
3.38
3.5
3.1
0.80
0.72
nmol/l
—
8
29
58
367
1.80
3.37
1.4
1.4
—
—
—
0
0
14
48
3.05
3.37
1.2
1.3
0.22
0.23
g/l
0.03
14
48
9
19
4.90
3.27
1.1
1.0
—
—
—
0
0
14
49
2.99
3.26
1.2
1.4
1.15
1.15
g/l
0.02
14
49
30
153
2.12
3.25
7.7
7.8
—
—
—
0
0
7
11
6.54
3.21
1.3
1.1
—
—
—
0
0
7
11
6.54
3.21
3.4
1.5
27.71
29.55
umol/l
—
7
11
58
373
1.77
3.18
1.5
1.3
0.75
1.20
u/ml
0.88
24
100
10
25
4.15
3.13
1.6
1.4
—
—
—
0
0
131
1053
1.65
3.04
5.8
4.1
—
—
—
0
0
71
489
1.68
3.03
4.5
3.1
0.71
0.39
e6/l
0.57
59
368
53
337
1.77
3.01
5.3
3.6
73.13
280.72
ng/l
1.76
40
274
5
5
10.20
2.99
1.0
1.2
146.60
182.53
mmol/24h
—
5
5
6
9
6.82
2.88
1.8
1.0
—
—
—
0
0
58
385
1.70
2.82
3.4
2.6
4.95
5.13
e6/l
0.05
50
347
68
471
1.66
2.81
4.5
3.1
—
—
—
0
0
13
48
2.82
2.77
1.4
1.7
—
—
—
0
0
5
6
8.50
2.76
1.2
1.2
—
—
—
0
0
27
141
2.05
2.76
2.0
1.4
—
—
—
0
0
56
374
1.68
2.64
2.8
2.9
326.16
6324.52
umol/l
1.76
51
306
160
1379
1.68
2.60
5.7
5.9
39.01
40.60
mmol/mol
1.09
148
1259
12
42
2.97
2.59
2.2
2.5
—
—
—
0
0
5
7
7.28
2.56
1.0
1.3
2.38
1.60
mmol/l
—
5
7
178
1586
1.82
2.49
41.2
14.5
—
—
—
0
0
11
38
3.00
2.45
1.9
10.1
—
—
—
0
0
26
140
1.98
2.45
6.5
4.0
—
—
—
0
0
27
149
1.93
2.38
3.7
2.1
43.15
29.36
u/l
0.79
27
122
7
17
4.22
2.38
1.9
3.7
—
—
—
0
0
7
17
4.22
2.38
2.6
4.1
—
—
—
0
0
6
13
4.72
2.29
2.3
1.5
4.48
4.48
nmol/l
—
6
13
6
13
4.72
2.29
3.3
2.2
38.08
34.95
%
—
6
13
10
35
2.95
2.24
1.1
1.3
—
—
—
0
0
36
224
1.73
2.18
2.1
1.8
—
—
—
0
0
185
1684
1.86
2.18
55.3
23.5
35.86
39.59
%
9.14
175
1571
5
10
5.09
2.08
1.8
1.8
—
—
—
0
0
13
57
2.37
2.02
3.7
2.5
—
—
—
0
0
30
184
1.74
1.92
1.9
1.5
—
—
—
0
0
8
28
2.93
1.88
1.0
9.6
46.69
63.69
%
—
8
28
6
17
3.60
1.85
1.3
1.1
—
—
—
0
0
31
197
1.67
1.75
2.6
2.6
183.82
139.26
ug/g
0.21
24
152
0
49
0.00
1.71
0.0
14.3
—
—
—
0
0
11
49
2.31
1.66
1.8
1.5
—
—
—
0
0
28
176
1.68
1.65
1.9
1.5
—
—
—
0
0
153
1362
1.46
1.62
3.8
4.0
1.21
1.26
mmol/l
0.52
137
1216
10
44
2.34
1.58
2.1
2.2
130.00
127.06
g/l
—
10
32
49
357
1.49
1.56
2.4
1.7
1.64
1.16
mg/l
0.75
41
285
5
15
3.39
1.53
4.0
2.3
0.99
1.05
e9/l
—
5
10
16
92
1.80
1.29
1.3
1.5
—
—
—
0
0
8
36
2.27
1.25
1.0
1.1
—
—
—
0
0
12
64
1.93
1.20
7.5
4.9
—
—
—
0
0
54
423
1.37
1.16
3.8
4.9
2.37
3.45
ug/l
0.49
47
351
5
20
2.54
1.16
1.2
1.2
—
—
—
0
0
5
20
2.54
1.16
1.4
1.1
—
—
—
0
0
28
194
1.51
1.14
1.4
1.3
—
—
—
0
0
7
32
2.23
1.09
1.0
1.3
0.78
0.84
nmol/l
—
7
26
24
163
1.53
1.07
1.3
1.3
—
—
—
0
0
32
233
1.44
1.03
1.3
1.3
16.82
34.13
iu/ml
1.42
11
78
7
131
0.52
1.03
1.7
1.6
—
—
—
0
0
7
35
2.03
1.01
2.7
1.4
—
—
—
0
0
156
1440
1.33
0.99
4.3
4.6
5.86
6.02
mmol/l
0.39
140
1284
5
23
2.20
0.98
1.0
1.5
—
—
—
0
0
16
101
1.63
0.97
2.4
2.5
—
16.52
—
0
6
48
381
1.34
0.95
4.4
4.3
—
—
—
0
0
6
30
2.03
0.87
7.5
2.6
—
—
—
0
0
8
44
1.85
0.87
1.1
1.4
—
—
—
0
0
8
47
1.73
0.81
1.1
1.4
—
—
—
0
0
8
47
1.73
0.81
1.1
1.4
—
—
—
0
0
8
47
1.73
0.81
1.1
1.4
—
—
—
0
0
8
48
1.69
0.79
7.1
4.1
—
—
—
0
0
8
48
1.69
0.79
1.1
1.4
—
—
—
0
0
30
386
0.74
0.78
1.6
1.6
1.49
1.33
mmol/l
0.56
23
317
14
92
1.56
0.74
3.4
2.6
—
—
—
0
0
7
38
1.87
0.74
1.0
1.5
—
—
—
0
0
152
1424
1.25
0.70
4.1
4.4
4.26
4.54
mmol/l
2.30
135
1291
7
42
1.69
0.69
1.7
1.4
—
—
—
0
0
5
27
1.87
0.69
4.0
2.9
—
—
—
0
0
5
28
1.80
0.66
1.2
1.6
—
—
—
0
0
150
1414
1.22
0.59
4.0
4.4
1.44
1.49
mmol/l
0.49
135
1272
6
36
1.69
0.57
1.2
2.1
12.55
12.84
mg/l
—
6
31
6
37
1.64
0.56
1.3
1.8
—
—
—
0
0
28
224
1.29
0.54
1.4
1.3
1.29
11.97
u/ml
—
10
82
12
83
1.47
0.53
1.8
1.3
416.39
218.29
u/ml
0.27
12
78
12
85
1.44
0.48
1.3
1.3
—
41.54
—
0
8
13
94
1.41
0.47
6.7
9.2
24.15
24.27
mmol/l
0.03
13
88
5
33
1.53
0.41
1.2
1.2
—
—
—
0
0
0
15
0.00
0.41
0.0
1.1
—
—
—
0
0
0
18
0.00
0.40
0.0
1.0
—
—
—
0
0
0
18
0.00
0.40
0.0
1.0
—
—
—
0
0
153
1471
1.15
0.36
4.3
5.0
2.40
2.64
mmol/l
2.26
139
1324
17
136
1.27
0.35
6.0
3.9
—
—
—
0
0
11
85
1.31
0.28
9.6
13.9
—
—
—
0
0
9
117
0.76
0.28
1.3
1.6
—
—
—
0
0
65
601
1.12
0.28
2.4
2.2
—
—
—
0
0
8
65
1.24
0.27
1.4
2.0
—
—
—
0
0
21
244
0.85
0.25
2.1
3.1
2.01
0.87
ug/l
0.54
15
160
39
429
0.89
0.23
3.0
3.0
160.06
360.07
mg/l
0.43
25
271
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
2.5
—
7.28
—
0
10
0
12
0.00
0.21
0.0
3.3
—
—
—
0
0
49
455
1.10
0.20
3.6
3.7
18.42
8.84
mg/mmol
0.47
34
278
50
465
1.10
0.19
3.0
3.0
6.43
6.86
mmol/l
0.27
40
388
13
114
1.15
0.12
1.6
1.4
—
—
—
0
0
14
125
1.13
0.10
1.3
1.2
—
—
—
0
0
5
44
1.14
0.10
1.4
1.3
—
—
—
0
0
49
471
1.05
0.08
2.9
2.9
—
—
—
0
0
8
77
1.04
0.07
1.1
1.3
—
—
—
0
0
12
109
1.11
0.06
1.9
1.6
—
—
—
0
0
10
109
0.91
0.04
4.7
3.5
—
—
—
0
0
14
133
1.06
0.01
1.5
1.6
—
—
—
0
0
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
6
59
1.02
0.00
1.3
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.8
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.4
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.6
—
9.01
—
0
7
0
7
0.00
-0.00
0.0
1.9
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
4.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.7
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.8
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.5
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.7
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
8
85
0.94
-0.00
6.9
3.6
—
—
—
0
0
0
5
0.00
-0.00
0.0
15.0
—
1.21
—
0
5

Mortality – FinRegistry

Association

Association between endpoint E4_PROTMALNAS and mortality.

Females

Parameter HR [95% CI] p-value
E4_PROTMALNAS 2.983 [1.98, 4.5] < 0.001
Birth year 0.999 [0.99, 1.01] 0.849

During the follow-up period (1.1.1998 — 31.12.2019), 423 out of 1180 females with E4_PROTMALNAS died.

Males

Parameter HR [95% CI] p-value
E4_PROTMALNAS 4.251 [2.36, 7.66] < 0.001
Birth year 0.993 [0.98, 1.0] 0.108

During the follow-up period (1.1.1998 — 31.12.2019), 339 out of 773 males with E4_PROTMALNAS died.

Mortality risk

Mortality risk for people of age

years, who have E4_PROTMALNAS.

N-year risk Females Males
1 0.239% 1.022%
5 1.836% 5.449%
10 5.126% 13.589%
15 9.269% 24.479%
20 16.303% 39.043%

Relationships between endpoints

Index endpoint: E4_PROTMALNAS – Unspecified protein-energy malnutrition

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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