protein energy malnutrition: A nutritional deficit that is caused by inadequate protein or calorie intake.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
181 |
4. Check minimum number of eventsNone |
181 |
5. Include endpointsNone |
181 |
6. Filter based on genotype QC (FinnGen only) |
181 |
Control definitions (FinnGen only)
- Control exclude
- E4_MALNUTRITION
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- E40-E46
- Name in latin
- Malnutritio non specificata ex deficientia proteino-energetica
Unspecified protein-energy malnutrition
based on the number of shared cases.
Similar with more cases:
Similar with less cases:
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 2837 | 1661 | 1166 |
| Only index persons | 2520 | 1510 | 1010 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.04 | 0.05 | 0.03 |
| Only index persons | 0.05 | 0.06 | 0.04 |
| Median age at first event (years) | |||
| Whole population | 75.04 | 77.51 | 71.59 |
| Only index persons | 75.85 | 78.14 | 72.43 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 181 | 102 | 79 |
| Unadjusted period prevalence (%) | 0.03 | 0.03 | 0.03 |
| Median age at first event (years) | 72.89 | 69.94 | 76.71 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 160
- Matched controls
- 1598
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
E46
ICD-10 Finland
Unspecified protein-energy malnutrition
+∞
214.9
154
*
E86
ICD-10 Finland
Volume depletion
14.5
16.6
28
23
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
3.3
11.5
80
369
Z50.9
ICD-10 Finland
Care involving use of rehabilitation procedure, unspecified
10.4
11.4
22
24
R63.4
ICD-10 Finland
Abnormal weight loss
10.8
11.1
21
22
N05AX08
ATC
risperidone; systemic
5.9
11.1
32
65
A28
ICPC
Limited function/disability NOS
3.8
10.8
55
195
E87.6
ICD-10 Finland
Hypokalaemia
10.5
9.5
18
19
Z46.8
ICD-10 Finland
Fitting and adjustment of other specified devices
8.7
8.6
18
23
SPAT1222
SPAT
Counselling/guidance promoting independent living
3.3
8.5
47
178
R4110
NOMESCO Finland
Physiotherapy
2.9
8.3
59
264
L28
ICPC
Limited function/disability (L)
3.2
8.1
48
190
N17.9
ICD-10 Finland
Acute renal failure, unspecified
7.4
7.8
18
27
R53
ICD-10 Finland
Malaise and fatigue
2.9
7.5
55
245
Z71.3
ICD-10 Finland
Dietary counselling and surveillance
6.8
7.5
18
29
D64.9
ICD-10 Finland
Anaemia, unspecified
3.7
7.3
33
106
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.7
7.2
60
291
C03CA01
ATC
furosemide; systemic
2.5
7.0
75
418
112
Kela drug reimbursment
Severe psychotic and other severe mental disorders
5.4
6.9
20
41
SPAT1230
SPAT
Aid fitting and borrowing and monitoring of use
2.9
6.9
45
188
I95.1
ICD-10 Finland
Orthostatic hypotension
6.0
6.8
18
33
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
4.0
6.8
27
77
F03
ICD-10 Finland
Unspecified dementia
5.0
6.8
21
47
A49.9
ICD-10 Finland
Bacterial infection, unspecified
3.4
6.7
34
119
J18.9
ICD-10 Finland
Pneumonia, unspecified
2.6
6.7
63
323
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
2.9
6.4
43
182
SPAT1229
SPAT
Assessment of need for aid
3.6
6.4
29
93
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
2.8
6.4
43
183
W19
ICD-10 Finland
Unspecified fall
3.6
6.3
28
89
N02AA05
ATC
oxycodone; systemic
3.0
6.2
38
151
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
4.4
6.1
21
53
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
65
191
4.75
21.10
3.3
2.4
18.1
22.9
%
1.54
58
161
80
290
4.15
19.41
2.4
1.8
1309.5
1116.2
nmol/l
1.17
61
212
92
385
3.83
17.83
2.7
2.3
3.6
3.1
mg/l
0.53
84
326
132
729
3.99
16.26
9.9
7.2
1.2
1.2
mmol/l
2.00
110
612
125
667
3.83
16.21
7.0
6.7
1.2
1.2
mmol/l
2.00
118
597
114
575
3.65
16.11
3.6
2.6
72.6
78.9
nmol/l
1.32
108
501
110
577
3.31
13.92
2.8
2.0
79.3
96.8
pmol/l
3.31
66
275
40
114
4.22
13.00
2.5
1.7
—
—
—
0
0
20
34
6.49
11.60
1.4
1.6
—
—
—
0
0
33
90
4.26
11.29
2.1
1.3
—
—
—
0
0
24
51
5.27
11.07
1.3
1.3
—
—
—
0
0
102
563
2.86
10.93
3.7
2.8
203.4
113.1
ug/l
1.87
94
505
94
500
2.83
10.77
4.2
3.1
2.3
2.4
mmol/l
2.08
87
432
19
36
5.78
9.87
1.4
1.4
221.8
291.0
ug/g
0.72
12
22
13
16
8.68
9.86
2.5
1.7
32.7
31.8
pg
0.17
13
16
96
536
2.68
9.73
5.8
3.4
—
—
—
0
0
75
378
2.68
9.24
5.7
4.6
0.0
0.0
estimate
0.00
25
122
54
230
2.92
9.17
5.8
3.2
6.5
3.0
e6/l
1.24
45
124
33
105
3.62
9.04
3.4
5.9
2.3
2.1
mmol/l
0.10
23
74
96
553
2.57
8.89
6.5
4.3
49.1
44.7
ng/l
0.12
85
396
92
525
2.53
8.62
6.3
4.4
—
—
—
0
0
109
675
2.55
8.54
7.5
5.7
0.0
0.0
estimate
0.00
27
124
35
123
3.29
8.20
3.3
3.6
100.9
71.1
ng/l
0.67
29
108
108
678
2.47
8.05
5.8
4.3
0.0
0.0
estimate
0.00
25
120
36
131
3.18
7.96
6.4
4.1
—
—
—
0
0
107
674
2.44
7.84
5.4
4.2
0.0
0.0
estimate
0.00
25
132
37
140
3.06
7.64
2.9
6.3
1.5
1.3
mmol/l
0.24
27
129
81
457
2.40
7.53
5.0
3.6
2908.7
1711.5
ng/l
1.05
75
378
77
427
2.40
7.42
3.6
2.2
243.1
234.0
u/l
0.04
71
403
60
312
2.38
6.55
1.9
1.9
462.6
471.7
pmol/l
0.07
42
255
37
153
2.78
6.47
5.8
3.8
1.8
2.1
mmol/l
0.14
30
114
66
361
2.30
6.40
2.2
1.6
20.9
22.1
nmol/l
0.19
59
300
17
43
4.26
6.32
1.2
3.3
55.0
87.8
mg/l
0.37
12
33
17
43
4.26
6.32
1.2
3.4
57.1
26.4
mg/l
0.65
12
33
93
589
2.19
6.26
5.2
4.2
—
—
—
0
0
133
978
2.36
6.12
5.5
4.1
17.7
12.7
mm/h
2.49
128
879
30
114
2.96
6.10
1.9
1.6
2.1
1.4
%
1.85
23
101
41
184
2.59
6.10
5.5
7.0
102.3
104.2
mmol/l
1.50
41
179
16
40
4.29
6.04
1.4
1.7
—
—
—
0
0
111
794
2.03
5.00
16.4
8.5
4.8
4.1
e9/l
2.09
106
685
53
293
2.14
4.83
4.3
3.1
2.5
2.5
mmol/l
0.55
48
248
109
782
1.99
4.79
4.7
3.0
74.2
46.5
u/l
1.22
103
722
18
59
3.28
4.66
1.7
2.7
3.2
3.7
g/l
—
7
45
18
59
3.28
4.66
1.7
2.7
7.0
7.6
g/l
—
7
46
18
59
3.28
4.66
1.7
2.7
—
—
—
0
0
10
21
4.98
4.59
5.7
2.6
62.0
60.0
%
—
10
21
10
22
4.75
4.36
1.0
1.1
—
—
—
0
0
126
970
1.98
4.30
4.7
3.9
15.2
15.1
pmol/l
0.22
119
853
9
15
6.25
3.86
1.1
1.2
—
—
—
0
0
6
6
10.28
3.52
19.7
15.7
1002.8
1530.2
nmol/l
—
6
6
6
6
10.28
3.52
17.3
12.5
804.7
795.2
nmol/l
—
6
6
41
231
2.00
3.46
2.2
2.0
—
—
—
0
0
142
1179
1.95
3.38
5.8
4.7
2.1
2.0
mu/l
0.29
136
1043
6
7
8.81
3.28
2.0
1.6
27.5
30.3
umol/l
—
6
7
154
1320
2.12
3.28
39.4
16.2
30.7
24.8
mg/l
1.15
143
1053
15
56
2.83
3.14
1.7
2.8
3.9
3.1
g/l
—
7
45
12
40
3.14
3.03
1.2
1.3
1.2
1.1
g/l
0.47
12
40
12
40
3.14
3.03
1.2
1.3
0.2
0.2
g/l
0.07
12
40
140
1175
1.85
2.99
34.6
15.7
75.6
76.0
ml/min/173m2
0.06
128
954
11
36
3.19
2.86
2.7
2.5
16.5
15.2
%
—
6
19
5
6
8.52
2.76
2.4
1.3
—
—
—
0
0
6
10
6.16
2.72
1.2
1.1
—
—
—
0
0
48
308
1.76
2.68
2.8
2.8
340.9
1972.4
umol/l
0.80
43
252
11
38
3.02
2.63
1.9
2.1
—
—
—
0
0
12
44
2.85
2.60
2.4
2.1
—
—
—
0
0
29
160
1.97
2.58
2.4
1.9
—
—
—
0
0
29
160
1.97
2.58
2.3
1.8
—
—
—
0
0
47
303
1.74
2.58
3.3
2.5
—
—
—
0
0
6
11
5.60
2.56
1.0
1.1
—
—
—
0
0
7
16
4.50
2.50
1.1
1.3
98.2
223.0
u/l
—
7
16
60
417
1.66
2.49
4.3
3.2
0.8
0.4
e6/l
0.50
50
312
30
172
1.89
2.39
2.9
9.3
2.0
1.4
mmol/l
0.27
21
128
6
13
4.73
2.29
1.2
1.6
11.3
13.2
u/l
—
6
13
7
19
3.79
2.17
1.0
1.8
—
—
—
0
0
7
19
3.79
2.17
1.7
1.2
—
—
—
0
0
7
19
3.79
2.17
1.0
1.8
—
—
—
0
0
29
171
1.83
2.13
2.9
9.4
11.0
11.4
kpa
0.18
29
161
29
171
1.83
2.13
2.9
9.4
5.1
5.0
kpa
0.03
29
161
8
25
3.30
2.12
1.1
1.5
—
—
—
0
0
9
31
3.00
2.10
1.1
1.7
—
—
—
0
0
47
320
1.63
2.08
1.4
1.3
0.8
1.0
u/ml
0.30
19
86
5
11
4.64
1.95
2.6
1.4
3.5
4.5
nmol/l
—
5
11
5
11
4.64
1.95
1.6
1.8
—
—
—
0
0
10
40
2.59
1.87
1.1
1.8
—
—
—
0
0
22
125
1.87
1.82
3.5
2.0
43.3
31.0
u/l
0.52
22
102
11
47
2.43
1.81
9.8
6.1
1.6
1.5
mg/l
0.05
11
39
42
290
1.58
1.75
5.5
3.7
87.3
278.0
ng/l
1.28
31
237
5
13
3.92
1.72
5.0
2.0
—
—
—
0
0
5
13
3.92
1.72
1.0
1.4
—
—
—
0
0
8
31
2.65
1.68
1.3
1.3
—
—
—
0
0
134
1182
1.51
1.65
5.8
5.9
39.1
40.6
mmol/mol
0.96
124
1084
10
43
2.40
1.63
1.1
1.7
—
—
—
0
0
8
32
2.57
1.61
1.0
1.3
—
—
—
0
0
6
21
2.92
1.52
2.2
2.0
—
—
—
0
0
6
22
2.78
1.44
1.2
1.3
—
—
—
0
0
15
82
1.90
1.40
2.3
1.9
—
—
—
0
0
41
296
1.50
1.39
2.0
1.7
1.5
1.1
mg/l
0.57
36
236
8
37
2.21
1.23
1.5
1.2
—
—
—
0
0
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
8
39
2.10
1.17
4.9
2.7
0.3
0.3
u/ml
—
8
21
128
1155
1.37
1.11
3.7
4.0
1.2
1.3
mmol/l
0.18
116
1036
8
41
1.99
1.10
1.9
1.3
—
—
—
0
0
5
21
2.42
1.10
1.2
2.0
—
—
—
0
0
43
332
1.39
1.03
3.6
5.0
2.6
2.8
ug/l
0.07
38
280
7
36
1.98
0.98
1.1
1.6
—
—
—
0
0
10
55
1.87
0.94
2.3
2.1
—
—
—
0
0
127
1163
1.31
0.88
29.8
16.9
35.9
39.4
%
2.29
62
820
6
31
1.97
0.85
1.0
1.2
0.7
0.8
nmol/l
—
6
26
24
323
0.70
0.83
1.4
1.7
1.5
1.3
mmol/l
0.55
19
266
10
58
1.77
0.81
2.3
2.3
—
—
—
0
0
6
33
1.85
0.80
1.2
2.0
0.9
3.0
mg/l
—
6
23
6
34
1.79
0.77
1.3
1.2
—
—
—
0
0
15
217
0.66
0.76
1.3
1.6
—
—
—
0
0
5
24
2.11
0.75
1.0
1.3
—
—
—
0
0
25
188
1.38
0.71
1.2
1.3
1.0
10.1
u/ml
—
9
73
7
42
1.69
0.69
2.1
1.5
—
—
—
0
0
5
28
1.81
0.66
1.0
1.3
—
—
—
0
0
11
164
0.65
0.65
1.5
1.4
—
—
—
0
0
29
233
1.29
0.55
4.3
2.8
1.0
1.1
e6/l
0.08
20
129
25
198
1.30
0.53
1.2
1.3
16.8
37.8
iu/ml
1.57
11
67
130
1229
1.21
0.50
4.3
4.7
5.7
6.0
mmol/l
2.01
118
1100
0
18
0.00
0.40
0.0
1.4
—
—
—
0
0
13
98
1.35
0.38
2.2
3.3
40.2
64.7
ml/min/173m2
—
6
34
5
36
1.40
0.38
1.8
1.5
—
—
—
0
0
5
36
1.40
0.38
1.8
1.5
—
—
—
0
0
16
125
1.31
0.38
5.3
2.9
367.0
233.2
ng/l
0.68
16
112
7
54
1.31
0.31
2.0
1.9
—
—
—
0
0
126
1211
1.13
0.29
4.2
4.4
4.3
4.6
mmol/l
1.28
114
1100
125
1201
1.13
0.29
4.0
4.4
1.5
1.5
mmol/l
0.41
114
1084
10
76
1.33
0.28
1.6
8.4
23.5
24.2
mmol/l
—
10
70
9
74
1.23
0.25
1.0
1.2
—
123.0
—
0
27
6
85
0.70
0.24
1.3
1.7
—
—
—
0
0
5
37
1.36
0.23
1.0
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
6
51
1.18
0.19
1.3
1.2
—
—
—
0
0
18
160
1.14
0.14
14.5
9.1
—
—
—
0
0
128
1252
1.08
0.14
4.2
4.9
2.5
2.6
mmol/l
1.40
118
1130
9
108
0.82
0.13
1.2
2.2
—
—
—
0
0
5
44
1.14
0.10
2.4
1.9
—
—
—
0
0
18
190
0.94
0.04
2.1
3.2
2.2
0.9
ug/l
0.55
13
125
25
257
0.97
0.01
3.9
4.5
21.7
21.8
%
0.01
14
121
0
8
0.00
0.00
0.0
1.6
—
—
—
0
0
0
5
0.00
0.00
0.0
2.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
0.00
0.0
1.6
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
0.3
—
0
5
5
52
0.96
0.00
1.4
1.2
—
—
—
0
0
9
97
0.92
0.00
1.0
2.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.6
—
—
—
0
0
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
7
76
0.92
0.00
1.4
1.4
—
—
—
0
0
75
750
1.00
0.00
2.6
2.9
—
—
—
0
0
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint E4_PROTMALNAS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_PROTMALNAS | 2.983 [1.98, 4.5] | < 0.001 |
| Birth year | 0.999 [0.99, 1.01] | 0.849 |
During the follow-up period (1.1.1998 — 31.12.2019), 423 out of 1180 females with E4_PROTMALNAS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_PROTMALNAS | 4.251 [2.36, 7.66] | < 0.001 |
| Birth year | 0.993 [0.98, 1.0] | 0.108 |
During the follow-up period (1.1.1998 — 31.12.2019), 339 out of 773 males with E4_PROTMALNAS died.
Mortality risk
Mortality risk for people of age
years, who have E4_PROTMALNAS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.239% | 1.022% |
| 5 | 1.836% | 5.449% |
| 10 | 5.126% | 13.589% |
| 15 | 9.269% | 24.479% |
| 20 | 16.303% | 39.043% |
Relationships between endpoints
↥Index endpoint: E4_PROTMALNAS – Unspecified protein-energy malnutrition
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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