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Unspecified protein-energy malnutrition

DOID EFO Endpoint Browser PheWeb

E4_PROTMALNAS

protein energy malnutrition: A nutritional deficit that is caused by inadequate protein or calorie intake.

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Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — E46
  • Hospital discharge: ICD-9 — 263[8-9]
  • Hospital discharge: ICD-8 — 26799
  • Cause of death: ICD-10 — E46
  • Cause of death: ICD-9 — 263[8-9]
  • Cause of death: ICD-8 — 26799

2 out of 7 registries used, show all original rules.

181

4. Check minimum number of events

None

181

5. Include endpoints

None

181

6. Filter based on genotype QC (FinnGen only)

181

Control definitions (FinnGen only)

Control exclude
E4_MALNUTRITION

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
E40-E46
Name in latin
Malnutritio non specificata ex deficientia proteino-energetica

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 2837 1661 1166
Only index persons 2520 1510 1010
Unadjusted period prevalence (%)
Whole population 0.04 0.05 0.03
Only index persons 0.05 0.06 0.04
Median age at first event (years)
Whole population 75.04 77.51 71.59
Only index persons 75.85 78.14 72.43

-FinnGen-

Key figures

All Female Male
Number of individuals 181 102 79
Unadjusted period prevalence (%) 0.03 0.03 0.03
Median age at first event (years) 72.89 69.94 76.71

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

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CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
160
Matched controls
1598
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
E46
ICD-10 Finland
Unspecified protein-energy malnutrition
+∞
214.9
154
*
E86
ICD-10 Finland
Volume depletion
14.5
16.6
28
23
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
3.3
11.5
80
369
Z50.9
ICD-10 Finland
Care involving use of rehabilitation procedure, unspecified
10.4
11.4
22
24
R63.4
ICD-10 Finland
Abnormal weight loss
10.8
11.1
21
22
N05AX08
ATC
risperidone; systemic
5.9
11.1
32
65
A28
ICPC
Limited function/disability NOS
3.8
10.8
55
195
E87.6
ICD-10 Finland
Hypokalaemia
10.5
9.5
18
19
Z46.8
ICD-10 Finland
Fitting and adjustment of other specified devices
8.7
8.6
18
23
SPAT1222
SPAT
Counselling/guidance promoting independent living
3.3
8.5
47
178
R4110
NOMESCO Finland
Physiotherapy
2.9
8.3
59
264
L28
ICPC
Limited function/disability (L)
3.2
8.1
48
190
N17.9
ICD-10 Finland
Acute renal failure, unspecified
7.4
7.8
18
27
R53
ICD-10 Finland
Malaise and fatigue
2.9
7.5
55
245
Z71.3
ICD-10 Finland
Dietary counselling and surveillance
6.8
7.5
18
29
D64.9
ICD-10 Finland
Anaemia, unspecified
3.7
7.3
33
106
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.7
7.2
60
291
C03CA01
ATC
furosemide; systemic
2.5
7.0
75
418
112
Kela drug reimbursment
Severe psychotic and other severe mental disorders
5.4
6.9
20
41
SPAT1230
SPAT
Aid fitting and borrowing and monitoring of use
2.9
6.9
45
188
I95.1
ICD-10 Finland
Orthostatic hypotension
6.0
6.8
18
33
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
4.0
6.8
27
77
F03
ICD-10 Finland
Unspecified dementia
5.0
6.8
21
47
A49.9
ICD-10 Finland
Bacterial infection, unspecified
3.4
6.7
34
119
J18.9
ICD-10 Finland
Pneumonia, unspecified
2.6
6.7
63
323
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
2.9
6.4
43
182
SPAT1229
SPAT
Assessment of need for aid
3.6
6.4
29
93
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
2.8
6.4
43
183
W19
ICD-10 Finland
Unspecified fall
3.6
6.3
28
89
N02AA05
ATC
oxycodone; systemic
3.0
6.2
38
151
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
4.4
6.1
21
53

Mortality – FinRegistry

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Association

Association between endpoint E4_PROTMALNAS and mortality.

Females

Parameter HR [95% CI] p-value
E4_PROTMALNAS 2.983 [1.98, 4.5] < 0.001
Birth year 0.999 [0.99, 1.01] 0.849

During the follow-up period (1.1.1998 — 31.12.2019), 423 out of 1180 females with E4_PROTMALNAS died.

Males

Parameter HR [95% CI] p-value
E4_PROTMALNAS 4.251 [2.36, 7.66] < 0.001
Birth year 0.993 [0.98, 1.0] 0.108

During the follow-up period (1.1.1998 — 31.12.2019), 339 out of 773 males with E4_PROTMALNAS died.

Mortality risk

Mortality risk for people of age

years, who have E4_PROTMALNAS.

N-year risk Females Males
1 0.239% 1.022%
5 1.836% 5.449%
10 5.126% 13.589%
15 9.269% 24.479%
20 16.303% 39.043%

Relationships between endpoints

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Index endpoint: E4_PROTMALNAS – Unspecified protein-energy malnutrition

GWS hits: 1

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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