quadriplegia: Paralysis of all four limbs. [database_cross_reference: NCIT:P378]
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
255 |
4. Check minimum number of eventsNone |
255 |
5. Include endpointsNone |
255 |
6. Filter based on genotype QC (FinnGen only) |
255 |
Control definitions (FinnGen only)
- Control exclude
- G6_CPETAL
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
Similar endpoints
↥List of similar endpoints to
Tetraplegia
based on the number of shared cases.
Similar with more cases:
- Cerebral palsy and other paralytic syndromes
- Neurological diseases
- Neurological diseases, wide definition
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 4087 | 1500 | 2554 |
| Only index persons | 3242 | 1232 | 2010 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.06 | 0.04 | 0.07 |
| Only index persons | 0.06 | 0.05 | 0.08 |
| Median age at first event (years) | |||
| Whole population | 50.34 | 49.30 | 50.77 |
| Only index persons | 48.83 | 47.36 | 49.72 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 255 | 97 | 158 |
| Unadjusted period prevalence (%) | 0.06 | 0.03 | 0.07 |
| Median age at first event (years) | 52.84 | 44.32 | 58.08 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 230
- Matched controls
- 2299
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
G82.5
ICD-10 Finland
Tetraplegia, unspecified
+∞
192.8
157
*
G82.4
ICD-10 Finland
Spastic tetraplegia
+∞
100.6
89
*
M03BX01
ATC
baclofen; systemic
121.4
77.1
80
10
T91.3
ICD-10 Finland
Sequelae of injury of spinal cord
894.3
69.9
65
*
G82.2
ICD-10 Finland
Paraplegia, unspecified
+∞
45.3
42
*
XKD06
NOMESCO Finland
Physiologic investigation of micturition
31.3
44.3
59
25
L89
ICD-10 Finland
Decubitus ulcer and pressure area
33.2
39.8
52
20
S14.0
ICD-10 Finland
Concussion and oedema of cervical spinal cord
447.6
39.3
38
*
Z46.8
ICD-10 Finland
Fitting and adjustment of other specified devices
34.1
37.8
49
18
N18
ICPC
Paralysis/weakness
35.2
37.4
48
17
N31.9
ICD-10 Finland
Neuromuscular dysfunction of bladder, unspecified
212.0
35.8
36
*
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
8.0
35.4
93
180
G95.8
ICD-10 Finland
Other specified diseases of spinal cord
+∞
34.2
32
*
KH1AE
NOMESCO Finland
Urinary tract ultrasound examination
13.1
33.6
62
63
S12.2
ICD-10 Finland
Fracture of other specified cervical vertebra
54.7
31.7
37
8
R4120
NOMESCO Finland
Occupational therapy
12.7
30.7
57
58
NA1AA
NOMESCO Finland
Cervical spine X-ray examination without contrast
17.5
30.1
48
34
SPAT1229
SPAT
Assessment of need for aid
11.6
29.7
58
65
TKC10
NOMESCO Finland
Percutaneous puncture of bladder
34.6
29.6
38
13
NA1BG
NOMESCO Finland
Cervical spine MRI examination with high intensity magnet
13.4
29.5
53
50
R33
ICD-10 Finland
Retention of urine
8.1
27.7
68
113
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
6.9
27.7
78
159
NA1CG
NOMESCO Finland
Cervical spine extensive MRI examination with high intensity magnet
31.4
26.7
35
13
ABC60
NOMESCO Finland
Decompression of cervical spinal cord
82.3
26.4
29
*
N39.0
ICD-10 Finland
Urinary tract infection, site not specified
7.4
26.1
68
123
XKC03
NOMESCO Finland
Water cystometry
21.4
25.8
38
21
SPAT1230
SPAT
Aid fitting and borrowing and monitoring of use
6.1
25.5
79
180
A28
ICPC
Limited function/disability NOS
6.5
25.4
74
156
L28
ICPC
Limited function/disability (L)
6.2
24.1
73
160
N03AX16
ATC
pregabalin; oral
4.7
23.0
96
302
N31.2
ICD-10 Finland
Flaccid neuropathic bladder, not elsewhere classified
69.6
22.3
25
*
R1250
NOMESCO Finland
Evaluation of functional capability
20.0
22.1
33
19
AA1AD
NOMESCO Finland
CT of head and brain
4.6
22.0
93
293
M47.1
ICD-10 Finland
Other spondylosis with myelopathy
29.9
21.9
29
11
A49.9
ICD-10 Finland
Bacterial infection, unspecified
6.8
21.9
60
114
G80.9
ICD-10 Finland
Cerebral palsy, unspecified
+∞
21.2
20
*
J01EA01
ATC
trimethoprim; systemic
4.4
20.9
95
319
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
5.8
20.9
65
145
N03AE01
ATC
clonazepam; systemic
9.1
20.6
45
60
UKC02
NOMESCO Finland
Cystoscopy
4.8
20.5
80
230
TKC20
NOMESCO Finland
Catheterisation of bladder
7.2
20.2
52
90
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
7.5
20.1
50
82
Z43.5
ICD-10 Finland
Attention to cystostomy
60.4
19.3
22
*
SPAT1167
SPAT
Insertion of urinary catheter
12.3
18.7
34
32
WX408
NOMESCO Finland
General anesthesy, balanced
3.8
18.7
104
408
WYA30
NOMESCO Finland
Preparations for expected poor cooperation
6.5
18.2
50
94
J01MA02
ATC
ciprofloxacin; systemic
3.5
18.2
126
588
N31.1
ICD-10 Finland
Reflex neuropathic bladder, not elsewhere classified
194.2
17.8
18
*
J01MA12
ATC
levofloxacin; systemic
4.1
17.7
81
266
N03AX12
ATC
gabapentin; oral
4.5
17.6
71
207
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
3.6
17.2
101
408
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
4.3
16.9
72
220
NA1AD
NOMESCO Finland
Cervical spine CT examination
9.8
16.7
34
40
SPAT1148
SPAT
Treatment of chronic ulcer or burn
4.6
16.2
62
170
G80.0
ICD-10 Finland
Spastic quadriplegic cerebral palsy
+∞
15.8
15
*
G82.3
ICD-10 Finland
Flaccid tetraplegia
+∞
15.8
15
*
A46
ICD-10 Finland
Erysipelas
4.6
15.7
60
164
T91.1
ICD-10 Finland
Sequelae of fracture of spine
171.0
15.7
16
*
QBG10
NOMESCO Finland
Excision and repair of bedsore of trunk
171.0
15.7
16
*
N30.0
ICD-10 Finland
Acute cystitis
4.7
15.3
57
151
KCV12
NOMESCO Finland
Urinary bladder endoscopic botulin therapy
48.5
15.3
18
*
N28
ICPC
Limited function/disability (N)
22.9
14.9
21
10
S97
ICPC
Chronic ulcer skin
7.9
14.8
34
49
S14.1
ICD-10 Finland
Other and unspecified injuries of cervical spinal cord
+∞
14.7
14
*
ABD40
NOMESCO Finland
Implantation of spinal injection device
+∞
14.7
14
*
KA1AE
NOMESCO Finland
Kidney ultrasound examination
14.7
14.6
24
18
SPAT1137
SPAT
Taking care of patient’s/customer’s hygiene
8.9
14.1
30
38
G99.2*M47.1
ICD-10 Finland
Spondylogenic compression of spinal cord
32.3
14.1
18
6
N99
ICPC
Neurological disease other
25.7
14.0
19
8
K59.09
ICD-10 Finland
Constipation, unspecified
7.0
14.0
35
57
N81
ICPC
Injury nervous system other
80.0
13.7
15
*
J18.9
ICD-10 Finland
Pneumonia, unspecified
3.3
13.7
86
354
G82.0
ICD-10 Finland
Flaccid paraplegia
+∞
13.7
13
*
9072A
ICD-9 Finland
Late effects of injuries to the nervous system, Late effect of spinal cord injury
+∞
13.7
13
*
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
3.8
13.4
63
206
U05
ICPC
Urination problems other
8.0
13.3
30
42
T81.4
ICD-10 Finland
Infection following a procedure, not elsewhere classified
4.9
13.1
45
109
J01MA06
ATC
norfloxacin; oral
4.3
13.1
52
146
J01XX05
ATC
methenamine; oral
53.1
13.0
15
*
GBB00
NOMESCO Finland
Tracheostomy
16.7
12.9
20
13
U07
ICPC
Urine symptom/complaint other
7.9
12.8
29
41
X58
ICD-10 Finland
Exposure to other specified factors
3.9
12.7
57
178
NAJ10
NOMESCO Finland
Anterior reduction of fracture of cervical spine
74.0
12.7
14
*
XKD03
NOMESCO Finland
Urethral pressure profilometry
14.3
12.7
21
16
G82.1
ICD-10 Finland
Spastic paraplegia
+∞
12.6
12
*
N31.8
ICD-10 Finland
Other neuromuscular dysfunction of bladder
137.1
12.6
13
*
R4110
NOMESCO Finland
Physiotherapy
3.1
12.5
85
365
Z50.9
ICD-10 Finland
Care involving use of rehabilitation procedure, unspecified
7.4
12.2
29
44
S12.7
ICD-10 Finland
Multiple fractures of cervical spine
68.5
11.7
13
*
U29
ICPC
Urinary symptom/complaint other
14.7
11.7
19
14
G80.1
ICD-10 Finland
Spastic diplegic cerebral palsy
+∞
11.5
11
*
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
2.9
11.5
88
406
N05BA01
ATC
diazepam; systemic, rectal
3.7
11.3
53
171
M48.0
ICD-10 Finland
Spinal stenosis
4.4
11.2
42
111
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
4.1
11.1
46
133
T90.5
ICD-10 Finland
Sequelae of intracranial injury
16.6
11.0
17
11
V49.9
ICD-10 Finland
Car occupant [any] injured in unspecified traffic accident
7.7
10.9
25
36
J01CA08
ATC
pivmecillinam; oral
2.8
10.8
85
395
A06AD11
ATC
lactulose; oral
3.5
10.8
54
183
QBG00
NOMESCO Finland
Debridement of bedsore of trunk
62.9
10.7
12
*
G95.0
ICD-10 Finland
Syringomyelia and syringobulbia
62.9
10.7
12
*
N02AX02
ATC
tramadol; systemic, rectal
2.6
10.6
115
639
TPH20
NOMESCO Finland
Insertion of central venous catheter through subclavian or brachiocephalic vein
12.9
10.5
18
15
W19
ICD-10 Finland
Unspecified fall
4.2
10.5
41
112
JN3AA
NOMESCO Finland
Abdominal X-ray examination without contrast
6.5
10.5
27
46
G80.3
ICD-10 Finland
Dyskinetic cerebral palsy
+∞
10.5
10
*
N06AX21
ATC
duloxetine; oral
4.0
10.2
43
126
SPAT1262
SPAT
Handing over of treatment supplies
3.2
10.1
60
231
R5140
NOMESCO Finland
Monitoring the use of the aid
4.0
10.1
42
122
W17
ICD-10 Finland
Other fall from one level to another
6.1
10.0
27
49
A41.5
ICD-10 Finland
Sepsis due to other Gram-negative organisms
11.4
10.0
18
17
R25.2
ICD-10 Finland
Cramp and spasm
10.7
9.7
18
18
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
4.3
9.7
36
94
NFL22
NOMESCO Finland
Myotomy or tenotomy of hip or thigh
104.0
9.5
10
*
A08
ICPC
Swelling
7.8
9.5
21
29
SPAT1226
SPAT
Implementation of occupational therapy rehabilitation plan
10.2
9.5
18
19
G82
ICD-10 Finland
Paraplegia and tetraplegia
+∞
9.4
9
*
NA2AA
NOMESCO Finland
Thoracal spine X-ray examination without contrast
8.3
9.3
20
26
N02AA05
ATC
oxycodone; systemic
3.4
9.3
48
166
N32.82
ICD-10 Finland
Instability of the detrusor vesicae muscle
14.5
9.3
15
11
X59
ICD-10 Finland
Exposure to unspecified factor
3.0
9.3
61
248
SPAT1296
SPAT
Other function in accordance with occupational therapy nomenclature
38.3
9.1
11
*
G99.2*M50.0
ICD-10 Finland
Cervical disc disorder with myelopathy
38.3
9.1
11
*
ZZR10
NOMESCO Finland
Flap of skin and muscle
38.3
9.1
11
*
TAW99
NOMESCO Finland
Other minor neurosurgical procedure
38.3
9.1
11
*
R13
ICD-10 Finland
Dysphagia
5.0
9.1
29
65
J96.1
ICD-10 Finland
Chronic respiratory failure
8.5
9.0
19
24
M03BX02
ATC
tizanidine; oral
2.4
9.0
145
964
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
4.4
9.0
33
85
NA1EA
NOMESCO Finland
Cervical spine X-ray examination with flexion
13.3
9.0
15
12
TPH04
NOMESCO Finland
Cathetrisation of vein
2.8
8.9
67
295
NF1AA
NOMESCO Finland
Hip X-ray examination
4.3
8.9
33
86
K59.0
ICD-10 Finland
Constipation
5.4
8.8
26
53
SPAT1231
SPAT
Assessment of adjustments needed in living environment
14.8
8.8
14
10
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
3.3
8.8
47
165
SPAT1215
SPAT
Assessment of need for medical rehabilitation
6.5
8.7
22
37
J69.0
ICD-10 Finland
Pneumonitis due to food and vomit
10.6
8.7
16
16
J01FF01
ATC
clindamycin; systemic
2.6
8.7
73
346
JDB10
NOMESCO Finland
Percutaneous gastrostomy
17.1
8.7
13
8
TAB00
NOMESCO Finland
Lumbar puncture
5.7
8.6
24
46
R53
ICD-10 Finland
Malaise and fatigue
2.9
8.6
57
232
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
5.0
8.5
27
60
JN4BD
NOMESCO Finland
Extensive body CT
3.6
8.5
39
123
SPAT1222
SPAT
Counselling/guidance promoting independent living
3.2
8.4
46
165
G81.9
ICD-10 Finland
Hemiplegia, unspecified
+∞
8.4
8
*
QDB10
NOMESCO Finland
Major dressing of wound of skin of lower limb
4.7
8.4
28
66
SPAT1216
SPAT
Assessment of functional ability
3.2
8.3
46
167
SPAT1295
SPAT
Other function in accordance with physical therapy nomenclature
5.3
8.2
24
49
RF120
NOMESCO Finland
NA
18.0
8.2
12
7
R1410
NOMESCO Finland
Drawing up a rehabilitation plan
34.7
8.1
10
*
N32.83
ICD-10 Finland
Nozzle synergy in the bladder neck
34.7
8.1
10
*
ZXM10
NOMESCO Finland
Intraoperative use of conventional X-ray imaging
5.6
8.1
23
45
NAG41
NOMESCO Finland
Anterior fusion of cervical spine with fixation
23.0
8.1
11
5
WX882
NOMESCO Finland
High dependency care
7.0
8.1
19
29
Z50.1
ICD-10 Finland
Other physical therapy
5.1
7.9
24
51
N31.0
ICD-10 Finland
Uninhibited neuropathic bladder, not elsewhere classified
46.5
7.8
9
*
NAG42
NOMESCO Finland
Posterior fusion of cervical spine with or without fixation
46.5
7.8
9
*
G99.2
ICD-10 Finland
Myelopathy in diseases classified elsewhere
46.5
7.8
9
*
K59.00
ICD-10 Finland
Constipation caused by slow bowel passage (SCT)
8.5
7.7
16
20
XG466
NOMESCO Finland
Sleep oxymetry
6.1
7.7
20
35
N06AA09
ATC
amitriptyline; systemic
3.7
7.7
34
104
S72.4
ICD-10 Finland
Fracture of lower end of femur
19.1
7.7
11
6
NA7BG
NOMESCO Finland
Spine and spinal cord MRI examination with high intensity magnet
26.0
7.6
10
*
WX872
NOMESCO Finland
Intensive care
4.5
7.6
26
63
TPH07
NOMESCO Finland
Cathetrisation of artery
3.4
7.6
37
123
R5130
NOMESCO Finland
Repair work or maintenance done on the aid
6.4
7.6
19
32
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
2.3
7.5
90
503
G99.2*M47.9
ICD-10 Finland
Myelopathy in spondylosis
82.6
7.5
8
*
R52.2
ICD-10 Finland
Other chronic pain
6.6
7.4
18
29
504
Kela drug reimbursment
Conditions requiring daily forced enteral nutrition
11.4
7.4
13
12
N30.9
ICD-10 Finland
Cystitis, unspecified
5.2
7.4
22
46
KCJ00
NOMESCO Finland
Cystostomy
+∞
7.3
7
*
S13.1
ICD-10 Finland
Dislocation of cervical vertebra
+∞
7.3
7
*
34302
ICD-8 Finland
Cerebral spastic infantile paralysis, Tetraplegia spastica
+∞
7.3
7
*
80690
ICD-8 Finland
Fracture and fracture dislocation of vertebral column with spinal cord lesion, Cervicalis, Sequelae
+∞
7.3
7
*
W16
ICD-10 Finland
Diving or jumping into water causing injury other than drowning or submersion
+∞
7.3
7
*
S24.0
ICD-10 Finland
Concussion and oedema of thoracic spinal cord
+∞
7.3
7
*
M41.4
ICD-10 Finland
Neuromuscular scoliosis
+∞
7.3
7
*
NB1AA
NOMESCO Finland
Shoulder X-ray examination without contrast
4.2
7.3
27
71
SPAT1220
SPAT
Assessment of need for rehabilitation and/or rehabilitation plan
4.3
7.3
26
66
A41.9
ICD-10 Finland
Sepsis, unspecified
7.0
7.3
17
26
G04AA01
ATC
NA
20.8
7.2
10
5
KCE02
NOMESCO Finland
Transluminal endoscopic extraction of calculus from bladder
20.8
7.2
10
5
NA7CG
NOMESCO Finland
Spine and spinal cord extensive MRI examination with high intensity magnet
12.6
7.2
12
10
H01BA02
ATC
desmopressin; nasal, systemic, sublingual
12.6
7.2
12
10
NE1AA
NOMESCO Finland
Pelvis X-ray examination
4.2
7.2
26
67
R5110
SPAT
NA
7.4
7.1
16
23
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
4.1
7.1
27
73
WX404
NOMESCO Finland
Intravenous generell anesthesy
2.5
7.0
59
274
TKC22
NOMESCO Finland
Catheterisation instruction
8.7
6.9
14
17
B01AB05
ATC
enoxaparin; parenteral
2.3
6.9
73
384
TNX92
NOMESCO Finland
Supporting bandage or orthosis of lower limb
9.8
6.9
13
14
NA3AD
NOMESCO Finland
Lumbar spine and sacrum CT examination
9.8
6.9
13
14
R50.9
ICD-10 Finland
Fever, unspecified
2.8
6.8
45
181
TJD20
NOMESCO Finland
Change of gastrostomy tube
41.3
6.8
8
*
C03CA01
ATC
furosemide; systemic
2.3
6.8
76
411
J01MA14
ATC
moxifloxacin; systemic
3.5
6.8
31
98
U04
ICPC
Incontinence urine
6.2
6.7
17
29
V89
ICD-10 Finland
Motor- or nonmotor-vehicle accident, type of vehicle unspecified
23.3
6.7
9
*
R4130
NOMESCO Finland
Speech therapy
8.2
6.7
14
18
JN3BD
NOMESCO Finland
Extensive abdominal CT
3.1
6.6
37
135
G04BD07
ATC
tolterodine; oral
6.0
6.6
17
30
SPAT1211
SPAT
Application of soft bandage
3.2
6.5
33
113
ZSA00
NOMESCO Finland
Procedure related to previous procedure classified in chapter A
71.7
6.5
7
*
NAJ12
NOMESCO Finland
Posterior reduction of fracture of cervical spine
71.7
6.5
7
*
NAG53
NOMESCO Finland
Posterior or lateral fusion of thoracic spine with fixation, more than 3 vertebraea
71.7
6.5
7
*
NA2CG
NOMESCO Finland
Thoracal spine extensive MRI examination with high intensity magnet
14.8
6.5
10
7
U13
ICPC
Bladder symptom/complaint other
6.9
6.4
15
23
308
Kela drug reimbursment
Alprostadil, sildenafil and combination product containing aviptadil and phentolamine
6.9
6.4
15
23
XKD00
NOMESCO Finland
Uroflowmetry
2.5
6.4
52
238
N03AF02
ATC
oxcarbazepine; oral
5.8
6.4
17
31
S22.0
ICD-10 Finland
Fracture of thoracic vertebra
8.5
6.4
13
16
111
Kela drug reimbursment
Epilepsy and comparable convulsive disorders
4.4
6.4
22
54
R1210
NOMESCO Finland
Medical assessment of need and possibilities to rehabilitation
11.5
6.4
11
10
M50.1
ICD-10 Finland
Cervical disc disorder with radiculopathy
4.8
6.3
20
45
AWB00
NOMESCO Finland
Reoperation for superficial infection in surgery of the nervous system
+∞
6.3
6
*
NDT99
NOMESCO Finland
Other operation on wrist or hand
+∞
6.3
6
*
34403
ICD-8 Finland
Other cerebral paralysis, Laesia medullaris non traumatica, sequelae
+∞
6.3
6
*
3432A
ICD-9 Finland
Infantile cerebral palsy, Quadriplegic[CP-OIREYHTYMÄ,TETRAPLEGIA SPASTICA]
+∞
6.3
6
*
P21.0
ICD-10 Finland
Severe birth asphyxia
+∞
6.3
6
*
L97
ICD-10 Finland
Ulcer of lower limb, not elsewhere classified
5.2
6.2
18
37
SPAT1156
SPAT
Guidance concerning treatment of rash and skin
2.8
6.2
39
154
N03AX09
ATC
lamotrigine; oral
4.2
6.2
22
56
R56.8
ICD-10 Finland
Other and unspecified convulsions
4.2
6.2
22
56
G47.3
ICD-10 Finland
Sleep apnoea
2.4
6.1
57
281
G04BD08
ATC
solifenacin; oral
4.0
6.1
23
62
S17
ICPC
Abrasion/scratch/blister
7.6
6.0
13
18
N29
ICPC
Neurological sympt/complt other
7.6
6.0
13
18
TQW11
NOMESCO Finland
Vacuum treatment of wound
7.6
6.0
13
18
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
88
308
3.84
21.58
2.3
1.9
—
—
—
0
0
16
12
14.16
16.94
4.2
1.2
—
—
—
0
0
116
564
2.94
15.72
6.2
3.0
0.5
0.4
e6/l
0.22
100
418
15
13
12.20
14.55
4.2
1.1
1.9
1.7
mmol/l
0.26
15
13
44
124
4.08
14.25
1.9
1.3
—
—
—
0
0
96
446
2.85
13.83
3.2
2.6
—
—
—
0
0
47
143
3.80
13.66
2.0
1.5
—
—
—
0
0
131
720
2.69
13.50
6.8
3.2
—
—
—
0
0
39
110
4.01
12.57
2.6
1.7
—
—
—
0
0
12
10
12.54
11.82
1.2
1.0
—
—
—
0
0
116
632
2.53
11.76
3.0
2.5
47.0
55.4
u/l
3.14
107
585
29
71
4.48
11.21
1.4
2.2
—
—
—
0
0
13
14
9.73
10.85
1.2
1.0
—
—
—
0
0
13
14
9.73
10.85
1.2
1.0
—
—
—
0
0
141
866
2.41
10.69
10.9
7.3
1.2
1.2
mmol/l
0.15
126
785
13
15
9.08
10.32
1.2
1.0
—
—
—
0
0
148
949
2.33
9.89
11.1
7.6
1.2
1.2
mmol/l
0.65
130
794
160
1061
2.36
9.88
6.9
6.7
11.1
12.3
umol/l
0.40
149
1007
134
834
2.28
9.49
5.5
4.7
32.5
35.7
g/l
5.45
124
781
69
321
2.58
9.45
3.6
4.4
0.8
0.8
mmol/l
0.08
62
304
18
36
5.30
8.75
1.6
1.4
—
—
—
0
0
18
36
5.30
8.75
1.6
1.4
—
—
—
0
0
69
333
2.47
8.68
5.8
2.7
1.0
1.0
e6/l
0.02
49
188
52
219
2.73
8.63
2.9
1.8
—
—
—
0
0
87
471
2.29
8.40
2.4
2.1
3.2
3.1
mg/l
0.12
68
410
120
749
2.14
8.06
3.4
2.3
86.0
75.5
nmol/l
2.45
104
664
51
221
2.63
7.97
3.0
1.8
—
—
—
0
0
24
66
3.91
7.94
1.6
1.8
—
—
—
0
0
69
347
2.36
7.85
1.9
1.7
1118.4
1221.8
nmol/l
0.42
51
254
135
890
2.10
7.76
4.9
4.1
—
—
—
0
0
64
313
2.39
7.74
6.7
3.0
3.2
1.6
e6/l
0.31
46
170
22
60
3.92
7.36
2.0
1.5
—
—
—
0
0
139
978
1.93
6.15
6.8
3.5
0.0
0.0
estimate
0.00
38
177
159
1170
1.95
6.14
8.5
10.0
4.4
4.2
e9/l
0.55
137
1022
49
236
2.33
6.04
15.6
10.1
2.5
1.1
mmol/l
1.22
41
187
9
6
15.48
5.94
1.2
1.0
—
—
—
0
0
111
738
1.89
5.72
2.4
1.9
81.9
92.9
pmol/l
1.85
64
386
194
1550
2.05
5.66
9.9
7.6
87.5
78.6
u/l
1.11
181
1446
47
234
2.24
5.34
4.1
4.5
32.3
31.5
%
0.19
35
147
9
8
11.60
5.33
2.6
2.3
—
—
—
0
0
41
193
2.34
5.31
4.7
3.3
—
—
—
0
0
72
428
1.95
5.11
1.9
2.1
1.7
1.3
mg/l
0.25
54
347
(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection
9
9
10.31
5.06
1.2
1.1
—
—
—
0
0
118
824
1.80
5.03
3.1
2.6
119.6
135.1
ug/l
0.41
97
758
135
982
1.80
5.01
9.1
4.8
0.0
0.0
estimate
0.00
37
180
136
994
1.79
4.94
7.0
3.5
0.0
0.0
estimate
0.00
38
168
90
590
1.81
4.66
3.0
3.7
1180.3
1264.2
ng/l
0.10
75
491
18
59
3.21
4.61
1.3
1.3
252.3
307.1
ug/g
0.57
11
36
165
1952
0.56
4.41
4.2
4.3
1.4
1.4
mmol/l
0.83
141
1784
171
2003
0.56
4.40
4.3
4.8
2.6
2.8
mmol/l
1.00
147
1825
45
239
2.07
4.32
13.8
23.6
1.0
1.3
inr
—
5
27
7
6
11.94
4.30
6.1
1.0
—
—
—
0
0
31
143
2.33
4.19
19.4
9.5
26.3
25.0
mmol/l
1.10
31
143
9
16
5.79
3.69
3.4
2.0
—
—
—
0
0
7
9
7.96
3.58
1.1
1.0
—
—
—
0
0
171
1965
0.61
3.33
4.0
4.3
4.4
4.6
mmol/l
1.65
147
1802
16
60
2.78
3.29
2.1
2.6
—
—
—
0
0
6
7
8.74
3.28
1.3
1.6
117.5
143.7
ug/l
—
6
7
41
233
1.91
3.25
3.2
3.6
10.3
9.8
umol/l
0.04
30
209
108
806
1.59
3.20
5.5
3.8
35.6
38.0
ng/l
0.08
95
567
67
445
1.69
3.16
1.7
1.5
22.7
20.7
nmol/l
0.42
55
382
12
39
3.18
3.13
1.5
1.7
—
—
—
0
0
25
120
2.20
3.10
1.2
1.3
—
24.8
—
0
10
164
1894
0.62
3.10
3.8
3.9
1.2
1.3
mmol/l
1.18
138
1729
57
365
1.72
3.06
3.7
3.4
35.9
225.0
ng/l
2.03
43
283
12
41
3.02
2.90
3.3
2.7
17.4
15.2
%
—
6
20
76
541
1.58
2.68
8.0
3.6
0.0
0.0
estimate
0.00
37
172
10
32
3.21
2.67
1.6
1.3
—
—
—
0
0
15
62
2.51
2.59
1.1
1.3
—
—
—
0
0
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
14
57
2.54
2.49
3.3
6.0
0.2
0.3
u/ml
—
9
31
7
18
3.97
2.27
1.0
1.3
—
—
—
0
0
7
18
3.97
2.27
1.0
1.3
—
—
—
0
0
48
318
1.63
2.26
2.9
2.2
10.2
14.2
umol/l
3.27
42
294
62
437
1.55
2.25
1.3
1.3
0.7
1.6
u/ml
1.00
16
107
7
19
3.76
2.16
1.0
1.3
—
—
—
0
0
7
19
3.76
2.16
1.0
1.3
—
—
—
0
0
7
19
3.76
2.16
1.0
1.3
—
—
—
0
0
5
10
5.07
2.08
1.2
1.1
—
—
—
0
0
14
64
2.26
1.98
1.2
2.1
—
—
—
0
0
84
649
1.44
1.93
3.6
3.5
42.6
31.4
u/l
0.73
77
619
168
1469
1.42
1.89
5.2
4.0
19.0
11.0
mm/h
5.07
151
1357
13
59
2.27
1.87
1.0
1.8
—
—
—
0
0
32
202
1.67
1.82
21.9
10.2
116.6
123.6
g/l
1.27
32
195
9
35
2.63
1.82
1.3
5.1
—
5308.4
—
0
5
12
54
2.28
1.77
1.7
2.9
32.9
31.9
mg/l
0.06
12
44
12
54
2.28
1.77
1.7
2.9
41.9
65.6
mg/l
0.45
12
44
29
180
1.69
1.76
2.3
2.8
25.9
34.1
u/l
1.13
22
152
8
30
2.72
1.74
1.8
1.8
—
—
—
0
0
7
24
2.97
1.73
1.3
1.2
—
—
nmol/l
—
0
0
79
620
1.40
1.64
2.4
3.3
2.3
2.3
mmol/l
3.14
65
552
5
14
3.62
1.62
1.2
1.4
—
—
—
0
0
5
14
3.62
1.62
1.2
1.4
—
—
—
0
0
5
14
3.62
1.62
1.2
1.4
—
—
—
0
0
5
14
3.62
1.62
1.2
1.4
—
—
—
0
0
54
397
1.46
1.59
1.6
1.7
444.6
452.3
pmol/l
0.07
44
341
11
50
2.25
1.59
1.5
1.5
—
—
—
0
0
10
204
0.47
1.57
1.1
2.1
—
—
—
0
0
7
27
2.64
1.52
1.4
1.6
—
—
—
0
0
12
224
0.51
1.47
1.5
1.4
—
—
—
0
0
11
52
2.17
1.46
1.2
1.3
—
1.8
—
0
12
7
28
2.54
1.46
1.4
1.6
—
—
—
0
0
7
28
2.54
1.46
1.4
1.6
—
—
—
0
0
7
28
2.54
1.46
1.3
1.6
—
—
—
0
0
35
240
1.53
1.45
8.5
7.5
—
—
—
0
0
40
284
1.48
1.41
3.2
2.2
17.0
24.5
%
4.32
31
252
94
775
1.34
1.40
8.4
3.5
—
—
—
0
0
7
29
2.45
1.40
1.4
1.6
—
—
—
0
0
7
29
2.45
1.40
1.4
1.6
—
—
—
0
0
9
41
2.24
1.38
2.1
1.4
—
—
—
0
0
41
294
1.47
1.38
3.2
2.2
2.3
2.3
g/l
0.31
36
274
5
17
2.98
1.36
1.4
1.2
—
—
—
0
0
10
47
2.17
1.35
1.0
1.2
—
—
—
0
0
67
527
1.37
1.35
2.3
2.8
324.6
4848.8
umol/l
1.58
52
453
9
42
2.18
1.35
2.1
5.3
—
859.7
—
0
6
6
24
2.53
1.31
1.0
1.1
—
—
—
0
0
6
24
2.53
1.31
1.3
1.2
0.5
0.5
nmol/l
—
6
18
13
69
1.93
1.31
1.8
1.8
2.9
3.1
g/l
—
8
54
161
1442
1.32
1.30
3.6
3.4
15.6
14.8
pmol/l
2.52
142
1310
6
25
2.43
1.25
1.2
2.2
—
—
—
0
0
5
19
2.66
1.22
1.0
1.8
—
—
—
0
0
6
26
2.34
1.19
1.8
2.1
—
—
—
0
0
0
33
0.00
1.17
0.0
1.1
—
13.9
—
0
26
145
1292
1.28
1.16
3.3
3.1
—
—
—
0
0
10
182
0.53
1.15
1.1
2.0
—
—
—
0
0
8
40
2.03
1.13
1.9
2.1
—
—
—
0
0
5
21
2.41
1.09
2.2
1.1
—
—
—
0
0
7
32
2.22
1.09
2.7
1.7
—
—
—
0
0
7
32
2.22
1.09
2.6
5.0
143.9
773.4
u/ml
—
7
32
10
52
1.96
1.07
2.0
2.0
—
—
—
0
0
10
52
1.96
1.07
2.0
2.0
—
—
—
0
0
28
197
1.47
1.05
1.8
2.1
13.0
13.8
nmol/l
0.14
22
176
13
76
1.75
1.01
1.8
1.7
4.3
3.9
g/l
—
8
53
13
76
1.75
1.01
1.8
1.7
7.3
7.5
g/l
—
8
56
13
76
1.75
1.01
1.8
1.7
—
—
—
0
0
17
108
1.62
0.99
4.1
3.8
1.3
1.3
%
0.01
17
108
7
36
1.97
0.98
2.9
1.7
—
—
—
0
0
214
2028
1.34
0.95
35.9
14.3
30.8
24.2
mg/l
1.89
197
1610
56
680
0.77
0.92
3.5
4.4
18.1
20.8
%
0.88
30
322
6
28
2.17
0.92
1.3
2.0
—
—
—
0
0
40
309
1.35
0.91
1.3
1.3
206.5
6.7
u/ml
—
8
121
11
63
1.78
0.91
1.2
1.3
—
—
—
0
0
152
1386
1.24
0.91
4.3
3.2
49.5
48.0
u/l
0.12
139
1298
8
42
1.93
0.89
2.8
1.6
—
—
—
0
0
171
1829
0.80
0.87
5.9
5.8
40.7
40.1
mmol/mol
0.25
150
1703
6
31
1.96
0.85
2.8
1.8
—
—
—
0
0
8
47
1.72
0.81
1.3
1.3
—
—
—
0
0
10
58
1.75
0.81
1.0
1.2
—
—
—
0
0
5
99
0.50
0.79
1.4
1.8
—
—
—
0
0
0
27
0.00
0.78
0.0
1.1
—
—
—
0
0
7
40
1.77
0.72
1.3
1.3
—
—
—
0
0
7
40
1.77
0.72
1.1
1.8
—
—
—
0
0
5
27
1.87
0.69
1.0
1.1
—
—
—
0
0
29
368
0.76
0.67
1.2
1.6
—
—
—
0
0
16
112
1.46
0.65
1.1
1.2
171.3
145.5
iu/ml
—
6
39
0
22
0.00
0.59
0.0
2.0
—
—
—
0
0
0
23
0.00
0.58
0.0
1.2
—
—
—
0
0
0
23
0.00
0.58
0.0
1.9
—
6.6
—
0
14
6
37
1.64
0.56
2.3
1.7
—
—
—
0
0
9
62
1.47
0.53
1.0
1.2
—
—
—
0
0
9
62
1.47
0.53
1.0
1.2
—
—
—
0
0
14
100
1.42
0.53
2.9
2.9
4.7
4.5
pmol/l
0.27
14
89
42
494
0.82
0.53
2.5
2.9
0.7
0.8
ug/l
0.52
29
318
0
16
0.00
0.41
0.0
3.7
—
—
—
0
0
0
17
0.00
0.41
0.0
1.4
—
—
—
0
0
185
1779
1.15
0.41
4.7
4.1
1.8
1.9
mu/l
0.76
167
1611
0
19
0.00
0.39
0.0
1.3
—
10.4
—
0
5
189
1832
1.12
0.31
26.0
13.1
96.2
82.1
ml/min/173m2
8.84
171
1494
7
53
1.33
0.31
1.0
1.4
—
—
—
0
0
180
1849
0.91
0.25
31.3
14.9
38.2
40.5
%
1.84
100
1369
186
1906
0.91
0.24
4.3
4.4
6.0
6.0
mmol/l
0.17
157
1732
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
0
12
0.00
0.21
0.0
1.1
—
—
—
0
0
0
13
0.00
0.21
0.0
3.4
—
—
—
0
0
0
13
0.00
0.21
0.0
3.4
—
—
—
0
0
13
108
1.21
0.20
1.1
1.0
—
—
—
0
0
212
2150
0.92
0.16
14.5
10.3
31.5
26.9
u/l
0.68
205
2065
47
500
0.93
0.15
1.6
1.7
1.5
1.4
mmol/l
0.56
40
422
6
57
1.05
0.08
1.0
1.1
—
3.6
—
0
5
83
852
0.96
0.08
5.2
4.8
1.6
2.3
ug/l
2.02
76
751
7
66
1.06
0.08
1.0
1.5
—
—
—
0
0
7
68
1.03
0.08
1.3
1.5
215.7
317.3
mu/l
—
7
62
21
197
1.07
0.06
3.7
4.5
7.4
30.6
ug/l
0.53
16
158
34
332
1.03
0.02
1.4
1.2
21.0
38.6
iu/ml
—
9
104
10
105
0.95
0.00
1.0
1.3
—
—
—
0
0
0
7
0.00
0.00
0.0
1.7
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.5
—
—
—
0
0
0
8
0.00
0.00
0.0
1.1
—
124.8
—
0
8
0
6
0.00
0.00
0.0
1.7
—
1.2
—
0
6
0
5
0.00
0.00
0.0
1.0
—
16.9
—
0
5
0
9
0.00
0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
0.00
0.0
2.7
—
—
—
0
0
0
5
0.00
0.00
0.0
3.2
—
—
—
0
0
0
8
0.00
0.00
0.0
8.5
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
0.00
0.0
1.7
—
—
—
0
0
0
9
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
2.2
—
—
—
0
0
6
66
0.91
0.00
1.8
1.7
143.3
242.4
pmol/l
—
6
60
0
8
0.00
0.00
0.0
1.3
—
9.4
—
0
8
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint G6_TETRAPLE and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_TETRAPLE | 4.524 [3.57, 5.73] | < 0.001 |
| Birth year | 0.996 [0.99, 1.0] | 0.319 |
During the follow-up period (1.1.1998 — 31.12.2019), 396 out of 1131 females with G6_TETRAPLE died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_TETRAPLE | 4.224 [3.6, 4.96] | < 0.001 |
| Birth year | 0.988 [0.98, 1.0] | 0.011 |
During the follow-up period (1.1.1998 — 31.12.2019), 782 out of 1973 males with G6_TETRAPLE died.
Mortality risk
Mortality risk for people of age
years, who have G6_TETRAPLE.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.438% | 0.861% |
| 5 | 2.374% | 5.06% |
| 10 | 6.461% | 12.798% |
| 15 | 11.992% | 21.439% |
| 20 | 20.747% | 34.276% |
Relationships between endpoints
↥Index endpoint: G6_TETRAPLE – Tetraplegia
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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