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Social disorders starting during childhood or adolescence

KRA_PSY_CHILDSOC

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 F94
  • Hospital discharge: ICD-9 3132C|3138X
  • Cause of death: ICD-10 F94
  • Cause of death: ICD-9 3132C|3138X

2 out of 7 registries used, show all original rules.

309

4. Check minimum number of events

None

309

5. Include endpoints

None

309

6. Filter based on genotype QC (FinnGen only)

309

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

First used in FinnGen datafreeze
DF2
Parent code in ICD-10
F90-F98
Name in latin
Perturbationes functionum socialium specialiter in pueritia incipientes

Similar endpoints

List of similar endpoints to Social disorders starting during childhood or adolescence based on the number of shared cases.

Venn diagram with an highlighted set fully inside another set Similar with more cases:

Venn diagram with a set fully inside an highlighted set Similar with less cases:

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

-FinnGen-

Key figures

All Female Male
Number of individuals 309 173 136
Unadjusted period prevalence (%) 0.06 0.06 0.06
Median age at first event (years) 11.27 12.22 10.05

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
286
Matched controls
2859
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
F94.0
ICD-10 Finland
Elective mutism
+∞
83.5
76
*
F94.8
ICD-10 Finland
Other childhood disorders of social functioning
+∞
75.4
69
*
F94.9
ICD-10 Finland
Childhood disorder of social functioning, unspecified
+∞
67.4
62
*
F94.1
ICD-10 Finland
Reactive attachment disorder of childhood
+∞
56.1
52
*
3138X
ICD-9 Finland
Disturbance of emotions specific to childhood and adolescence, Other or mixed emotional disturbances of childhood or adolescence[MUU MÄÄRITTELTY EMOTIONAALISENA OIREENA ILM. HÄIRIÖ]
+∞
41.7
39
*
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
5.3
32.8
124
359
N05AH04
ATC
quetiapine; oral
5.0
30.2
119
354
112
Kela drug reimbursment
Severe psychotic and other severe mental disorders
7.7
29.5
74
124
N05AH03
ATC
olanzapine; systemic
7.0
26.7
71
128
N05AX08
ATC
risperidone; systemic
7.2
26.1
68
119
R4160
NOMESCO Finland
Other therapy enhancing rehabilitation
10.3
22.9
46
52
Z2445
NOMESCO Finland
Psychologist
5.5
21.8
71
163
F92.8
ICD-10 Finland
Other mixed disorders of conduct and emotions
25.6
21.8
30
13
F92.9
ICD-10 Finland
Mixed disorder of conduct and emotions, unspecified
25.6
21.8
30
13
Z2446
NOMESCO Finland
Social worker
4.9
21.0
77
201
T36
ICD-10 Finland
Poisoning by systemic antibiotics
6.8
20.2
53
92
F29
ICD-10 Finland
Unspecified nonorganic psychosis
6.3
20.0
56
106
N05AX12
ATC
aripiprazole; systemic
6.0
18.9
55
109
N03AG01
ATC
valproic acid; systemic, rectal
6.7
18.6
49
85
X69
ICD-10 Finland
Intentional self-poisoning by and exposure to other and unspecified chemicals and noxious substances
7.6
17.9
43
65
F32.9
ICD-10 Finland
Depressive episode, unspecified
3.8
17.9
88
299
F93.89
ICD-10 Finland
Other childhood emotional disorders
8.7
17.8
39
51
R5599
NOMESCO Finland
Other rehabilitation service
12.7
17.5
31
27
ZY010
NOMESCO Finland
Hospital outpatient
4.6
16.6
62
162
ICZ03
NOMESCO Finland
Participation in compiling a psychiatric treatment plan
5.0
16.4
56
133
F84.9
ICD-10 Finland
Pervasive developmental disorder, unspecified
28.2
15.8
21
8
Z3231
NOMESCO Finland
Registered nurse
3.0
15.7
118
541
F90.0
ICD-10 Finland
Disturbance of activity and attention
4.5
15.3
58
153
ZYC01
NOMESCO Finland
Remote contact by phone
5.5
14.9
46
97
N05AF03
ATC
chlorprothixene; systemic
12.9
14.9
26
22
F94.2
ICD-10 Finland
Disinhibited attachment disorder of childhood
+∞
14.7
14
*
N05BA01
ATC
diazepam; systemic, rectal
4.6
14.7
54
138
ZXE06
NOMESCO Finland
Procedure duration 50 to 59 minutes
4.7
14.4
52
130
ZXE03
NOMESCO Finland
Procedure duration 20 to 29 minutes
5.5
14.4
44
92
N06AB03
ATC
fluoxetine; oral
4.2
14.2
58
164
ICB01
NOMESCO Finland
Psychiatric treatment plan, standard
4.9
14.0
48
114
R1100
NOMESCO Finland
General evaluation of the need for rehabilitation
7.0
13.7
34
54
N05AA02
ATC
levomepromazine; systemic
9.3
13.6
28
33
IGY01
NOMESCO Finland
Accelerated psychiatric treatment contact
6.6
13.5
35
59
N06AX16
ATC
venlafaxine; oral
3.7
13.4
64
207
F92.0
ICD-10 Finland
Depressive conduct disorder
13.1
13.4
23
19
N05AH02
ATC
clozapine; systemic
7.4
13.1
31
46
Z61.8
ICD-10 Finland
Other negative life events in childhood
20.2
13.1
19
10
F84.5
ICD-10 Finland
Asperger syndrome
10.4
13.0
25
26
IGY99
NOMESCO Finland
Other psychiatric treatment contact
5.3
12.9
40
85
Z63.7
ICD-10 Finland
Other stressful life events affecting family and household
6.6
12.9
33
55
ZXE05
NOMESCO Finland
Procedure duration 40 to 49 minutes
4.8
12.4
42
98
N05CF01
ATC
zopiclone; oral
3.6
12.4
60
196
R1220
NOMESCO Finland
Psychological examination of need and possibilities to rehabilitation
10.0
12.3
24
26
F20.9
ICD-10 Finland
Schizophrenia, unspecified
10.8
12.2
23
23
N05BA04
ATC
oxazepam; oral
3.1
12.2
75
292
ZXY51
NOMESCO Finland
2-person team, doctor-nurse
7.1
11.9
29
45
IBZ01
NOMESCO Finland
Profession-specific psychiatric evaluation
5.2
11.9
37
79
ZXE02
NOMESCO Finland
Procedure duration 10 to 19 minutes
5.2
11.9
37
79
F32.3
ICD-10 Finland
Severe depressive episode with psychotic symptoms
7.7
11.8
27
38
F80.9
ICD-10 Finland
Developmental disorder of speech and language, unspecified
11.8
11.7
21
19
ZXE13
NOMESCO Finland
Procedure duration 90 to 119 minutes
4.2
11.6
45
121
F60.3
ICD-10 Finland
Emotionally unstable personality disorder
15.9
11.5
18
12
F32.10
ICD-10 Finland
Moderate depressive episode without somatic syndrome
3.4
11.3
61
214
ZXE04
NOMESCO Finland
Procedure duration 30 to 39 minutes
4.4
11.3
42
108
N06BA04
ATC
methylphenidate; oral
4.5
11.3
41
103
IGV01
NOMESCO Finland
Psychiatric network contact
7.0
11.1
27
42
N05BE01
ATC
buspirone; oral
12.6
11.0
19
16
N03AX09
ATC
lamotrigine; oral
4.7
11.0
38
91
ZXE15
NOMESCO Finland
Procedure duration 120 to 149 minutes
5.4
10.9
33
68
ZXE11
NOMESCO Finland
Procedure duration 60 to 89 minutes
3.4
10.9
56
191
IEY05
NOMESCO Finland
Dedicated profession-specific psychiatric intervention, individual
4.2
10.7
41
109
J18.9
ICD-10 Finland
Pneumonia, unspecified
3.2
10.5
58
208
F41.9
ICD-10 Finland
Anxiety disorder, unspecified
2.9
10.5
69
279
Z63.8
ICD-10 Finland
Other specified problems related to primary support group
24.4
10.3
14
6
N06AB04
ATC
citalopram; systemic
3.3
10.1
55
193
IGP01
NOMESCO Finland
Psychiatric family contact
6.1
10.1
27
48
Z2221
NOMESCO Finland
Medical doctor
2.5
9.9
96
482
Z3226
NOMESCO Finland
Physiotherapist
2.7
9.9
75
331
F32.2
ICD-10 Finland
Severe depressive episode without psychotic symptoms
3.5
9.5
45
144
3138C
ICD-9 Finland
Disturbance of emotions specific to childhood and adolescence, Other or mixed emotional disturbances of childhood or adolescence[LAPSUUSIÄN RAJATILAHÄIRIÖ]
+∞
9.4
9
*
F60.9
ICD-10 Finland
Personality disorder, unspecified
11.2
9.4
17
16
Z03.2
ICD-10 Finland
Observation for suspected mental and behavioural disorders
6.0
9.3
25
45
F60.30
ICD-10 Finland
Emotionally unstable personality disorder, impulsive
6.0
9.3
25
45
F33.9
ICD-10 Finland
Recurrent depressive disorder, unspecified
4.9
9.3
30
67
P72
ICPC
Schizophrenia
9.5
9.2
18
20
ZXE20
NOMESCO Finland
More than three and less than five hours
3.6
9.1
42
131
F88
ICD-10 Finland
Other disorders of psychological development
16.3
9.1
14
9
N06AB06
ATC
sertraline; oral
3.1
9.1
54
201
F10.1
ICD-10 Finland
Mental and behavioural disorders due to use of alcohol, Harmful use
4.5
8.9
31
75
N06AX11
ATC
mirtazapine; oral
2.5
8.8
82
402
Z61.1
ICD-10 Finland
Removal from home in childhood
51.6
8.7
10
*
F83
ICD-10 Finland
Mixed specific developmental disorders
5.7
8.7
24
45
R2130
NOMESCO Finland
Counselling and guidance which enhance independent living
3.5
8.6
41
132
F20.30
ICD-10 Finland
Undifferentiated schizophrenia continuous
9.0
8.4
17
20
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
3.7
8.4
36
106
3132C
ICD-9 Finland
Disturbance of emotions specific to childhood and adolescence, Sensitivity, shyness and social withdrawal disorder
+∞
8.4
8
*
F70.1
ICD-10 Finland
Mild mental retardation, Significant impairment of behaviour requiring attention or treatment
+∞
8.4
8
*
N06AB10
ATC
escitalopram; oral
2.4
8.4
81
402
F80.2
ICD-10 Finland
Receptive language disorder
6.9
8.3
20
31
F99
ICD-10 Finland
Mental disorder, not otherwise specified
6.9
8.3
20
31
F80.1
ICD-10 Finland
Expressive language disorder
6.4
8.3
21
35
ICC04
NOMESCO Finland
Psychiatric treatment plan, permanent discontinuation
4.8
8.3
27
61
F43.1
ICD-10 Finland
Post-traumatic stress disorder
4.9
8.2
26
57
XF400
NOMESCO Finland
ECG with 12 standard connections
2.9
8.1
50
193
F93.1
ICD-10 Finland
Phobic anxiety disorder of childhood
22.8
8.1
11
5
ZXD10
NOMESCO Finland
Scheduled procedure
2.2
7.9
100
562
R1210
NOMESCO Finland
Medical assessment of need and possibilities to rehabilitation
8.8
7.9
16
19
P29
ICPC
Psychological sympt/compl other
2.9
7.7
48
186
F84.8
ICD-10 Finland
Other pervasive developmental disorders
19.0
7.7
11
6
F93.9
ICD-10 Finland
Childhood emotional disorder, unspecified
7.5
7.6
17
24
N03AE01
ATC
clonazepam; systemic
6.3
7.5
19
32
F20.00
ICD-10 Finland
Paranoid schizophrenia continuous
8.0
7.5
16
21
N05AN01
ATC
lithium; oral
7.2
7.4
17
25
N05AB03
ATC
perphenazine; systemic, rectal
7.2
7.4
17
25
P74
ICPC
Anxiety disorder/anxiety state
3.4
7.4
35
112
IGY02
NOMESCO Finland
Psychiatric monitoring contact
3.7
7.4
31
90
IEV99
NOMESCO Finland
Other psychiatric network intervention
6.5
7.4
18
29
ZXY82
NOMESCO Finland
Nurse in multidisciplinary team
9.7
7.4
14
15
R4140
NOMESCO Finland
Psychotherapy
9.7
7.4
14
15
IEP03
NOMESCO Finland
Focused parental counselling
7.6
7.3
16
22
F33.10
ICD-10 Finland
Recurrent depression, moderate episode without somatic syndrome
3.6
7.3
32
97
R4120
NOMESCO Finland
Occupational therapy
4.1
7.2
27
71
RS214
NOMESCO Finland
NA
20.6
7.2
10
5
ZXE10
NOMESCO Finland
More than one and less than three hours
2.2
7.1
90
503
S29
ICPC
Skin symptom/complaint other
2.5
7.1
58
262
K02.1
ICD-10 Finland
Caries of dentine
2.0
7.0
199
1522
N05BA06
ATC
lorazepam; systemic, sublingual
5.3
6.9
20
40
ZY000
NOMESCO Finland
Hospital inpatient
5.9
6.9
18
32
F70.0
ICD-10 Finland
Mild mental retardation, With the statement of no, or minimal, impairment of behaviour
9.7
6.9
13
14
3153X
ICD-9 Finland
Specific delays in development, Developmental speech or language disorder[PUHEEN KEHITYKSEN ERITYISVAIKEUS]
41.1
6.8
8
*
N05AA01
ATC
chlorpromazine; systemic, rectal
41.1
6.8
8
*
ICB03
NOMESCO Finland
Psychiatric treatment plan, monitoring
4.8
6.7
21
46
ZXE30
NOMESCO Finland
More than five and less than seven hours
4.6
6.7
22
51
Z71.8
ICD-10 Finland
Other specified counselling
2.1
6.7
92
531
IAA01
NOMESCO Finland
Assessment of need for psychiatric treatment
3.7
6.6
28
82
R56.8
ICD-10 Finland
Other and unspecified convulsions
3.1
6.4
33
114
WYA30
NOMESCO Finland
Preparations for expected poor cooperation
2.7
6.3
43
174
F89
ICD-10 Finland
Unspecified disorder of psychological development
18.5
6.3
9
5
F60.31
ICD-10 Finland
Emotionally unstable personality disorder, borderline condition
6.5
6.2
15
24
C07AB07
ATC
bisoprolol; oral
2.6
6.2
46
198
F41.1
ICD-10 Finland
Generalized anxiety disorder
3.0
6.2
35
127
N06AB05
ATC
paroxetine; oral
4.0
6.1
23
61
ZXE21
NOMESCO Finland
Procedure duration at least 3 but less than 4 hours
8.9
6.1
12
14
N05CD07
ATC
temazepam; oral
7.0
6.1
14
21
F10.29
ICD-10 Finland
Addiction caused by alcohol UNS
10.3
6.1
11
11
F80.8
ICD-10 Finland
Other developmental disorders of speech and language
10.3
6.1
11
11
P99
ICPC
Psychological disorders other
4.3
6.0
21
52
TPH07
NOMESCO Finland
Cathetrisation of artery
3.6
6.0
26
78
ZXE00
NOMESCO Finland
One hour or less
1.9
6.0
115
745
F82
ICD-10 Finland
Specific developmental disorder of motor function
5.0
6.0
18
38

Mortality – FinRegistry

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

Relationships between endpoints

Index endpoint: KRA_PSY_CHILDSOC – Social disorders starting during childhood or adolescence

GWS hits: -

This endpoint is excluded from FinRegistry analyses (omitted endpoint).