Cutis laxa senilis

L12_CUTLAXSEN

photosensitivity disease: Photosensitivity refers to various symptoms, diseases and conditions caused or aggravated by exposure to sunlight.

Suggest a new description

Endpoint definition

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

519972

1. Apply sex-specific rule

None

519972

2. Check conditions

None

519972

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 L57.4
  • Hospital discharge: ICD-9 7018B
  • Cause of death: ICD-10 L57.4
  • Cause of death: ICD-9 7018B

2 out of 7 registries used, show all original rules.

277

4. Check minimum number of events

None

277

5. Include endpoints

None

277

6. Filter based on genotype QC (FinnGen only)

266

Control definitions (FinnGen only)

Control exclude
L12_RADIATIONRELATEDSKIN

Extra metadata

Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
L57
Name in latin
Cutis laxa senilis

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 1483 1319 155
Only index persons 1385 1244 141
Unadjusted period prevalence (%)
Whole population 0.03 0.04 0.00
Only index persons 0.04 0.05 0.01
Median age at first event (years)
Whole population 55.73 54.96 62.05
Only index persons 55.47 54.72 62.05

-FinnGen-

Key figures

All Female Male
Number of individuals 266 242 24
Unadjusted period prevalence (%) 0.08 0.09 0.01
Median age at first event (years) 56.18 55.40 64.09

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
277
Matched controls
2770
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
L57.4
ICD-10 Finland
Cutis laxa senilis
+∞
307.7
257
*
QAJ30
NOMESCO Finland
Other facelift
522.2
81.4
77
*
QBJ30
NOMESCO Finland
Correction of abdominal apron
310.5
72.0
70
*
H02.3
ICD-10 Finland
Blepharochalasis
5.7
25.8
55
116
9862
FHL
Facial skin shaping surgery (Faclift)
+∞
23.2
22
*
7018B
ICD-9 Finland
Other hypertrophic and atrophic conditions of skin, Other specified hypertrophic and atrophic conditions of skin[ELASTOSIS SENILIS]
+∞
21.1
20
*
L57.0
ICD-10 Finland
Actinic keratosis
5.7
19.5
39
77
E66.8
ICD-10 Finland
Other obesity
5.7
19.2
39
78
QBJ00
NOMESCO Finland
Liposuction in trunk
23.8
15.8
22
10
J01DB01
ATC
cefalexin; oral
4.3
11.3
255
2020
Z41.1
ICD-10 Finland
Other plastic surgery for unacceptable cosmetic appearance
29.4
10.8
14
5
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
2.3
10.6
153
964
QAJ99
NOMESCO Finland
Other aesthetic operations on skin of head or neck
+∞
10.5
10
*
A02BC05
ATC
esomeprazole; systemic
2.3
10.4
149
932
J01EA01
ATC
trimethoprim; systemic
2.3
9.7
116
668
QAJ15
NOMESCO Finland
Browlift using video-endoscope
103.4
9.5
10
*
E66.01
ICD-10 Finland
Obesity due to excess calories
3.2
9.2
40
140
N06AB10
ATC
escitalopram; oral
2.4
9.0
77
382
P06
ICPC
Sleep disturbance
2.8
8.6
47
187
J02AC01
ATC
fluconazole; systemic
2.1
8.4
150
996
Z42.2
ICD-10 Finland
Follow-up care involving plastic surgery of other parts of trunk
+∞
8.4
8
*
QBE20
NOMESCO Finland
Excision and repair of scar or web of skin of trunk
15.1
8.3
13
9
N06AB04
ATC
citalopram; systemic
2.2
8.1
84
452
H02BX01
ATC
methylprednisolone, combinations; systemic
3.7
7.9
26
76
M19.0
ICD-10 Finland
Primary arthrosis of other joints
2.7
7.8
47
197
QAJ10
NOMESCO Finland
Browlift
46.3
7.8
9
*
CBJ50
NOMESCO Finland
Operation for ptosis of eyebrow
19.0
7.7
11
6
JDF11
NOMESCO Finland
Laparoscopic gastric bypass
9.8
7.4
14
15
XKC03
NOMESCO Finland
Water cystometry
4.5
7.3
18
42
QBJ05
NOMESCO Finland
Other correction of loose or redundant skin of trunk
+∞
7.3
7
*
M62.0
ICD-10 Finland
Diastasis of muscle
+∞
7.3
7
*
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
2.0
7.3
119
755
L03
ICPC
Low back symptom/complaint
2.1
7.2
100
598
N02BF01
ATC
gabapentin; oral
2.8
7.1
39
155
N05BA12
ATC
alprazolam; oral
2.6
7.1
45
193
WX402
NOMESCO Finland
General anaesthesia
2.2
7.0
71
375
SAA04
NOMESCO Finland
Special examination of mouth
3.6
7.0
24
72
F32.9
ICD-10 Finland
Depressive episode, unspecified
2.6
7.0
45
195
N06AB03
ATC
fluoxetine; oral
2.5
6.9
50
228
TQW99
NOMESCO Finland
Other minor procedure on skin
3.8
6.9
21
58
E66.9
ICD-10 Finland
Obesity, unspecified
3.9
6.8
20
54
M54.5
ICD-10 Finland
Low back pain
1.9
6.7
118
764
M51.3
ICD-10 Finland
Other specified intervertebral disc degeneration
2.9
6.6
33
125
M75.1
ICD-10 Finland
Rotator cuff syndrome
2.0
6.6
88
516
CBB11
NOMESCO Finland
Resection of lax skin in upper eyelid
6.0
6.6
17
30
TPH04
NOMESCO Finland
Cathetrisation of vein
2.1
6.5
73
401
N05CF01
ATC
zopiclone; oral
1.9
6.5
113
726
N02AX02
ATC
tramadol; systemic, rectal
1.9
6.5
135
921
QAJ05
NOMESCO Finland
Other correction of loose or redundant skin of head or neck
+∞
6.3
6
*
QAJ00
NOMESCO Finland
Liposuction in head or neck
+∞
6.3
6
*
N39.4
ICD-10 Finland
Other specified urinary incontinence
2.4
6.3
47
218
S29
ICPC
Skin symptom/complaint other
2.1
6.1
67
364
SFA00
NOMESCO Finland
Small restoration
2.3
6.1
48
228
U71
ICPC
Cystitis/urinary infection other
2.7
6.0
33
131
J01DA01
ATC
[U] cefalexin
1.9
6.0
190
1469

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
115
742
1.94
6.53
2.1
1.9
116.29
146.36
u/l
1.09
110
694
156
1125
1.89
6.21
2.4
2.5
—
—
—
0
0
41
186
2.41
5.73
1.3
1.1
—
—
—
0
0
221
1822
2.05
5.50
4.8
4.1
11.40
12.57
mm/h
0.64
212
1651
152
1114
1.81
5.49
5.3
5.1
1.21
1.22
mmol/l
1.69
139
1005
204
1645
1.91
5.31
5.6
4.4
—
—
—
0
0
140
1017
1.76
5.08
2.3
2.0
89.57
97.72
pmol/l
1.19
67
482
112
764
1.78
5.04
2.5
2.2
53.58
55.49
u/l
0.38
106
703
159
1213
1.73
4.72
6.3
5.9
1.22
1.23
mmol/l
1.10
144
1030
175
1388
1.71
4.36
4.6
4.0
6.23
6.60
mmol/l
1.85
164
1288
53
298
1.96
4.32
1.9
1.8
96.90
124.26
ug/g
0.55
39
234
221
1878
1.87
4.27
7.8
7.0
72.44
78.15
u/l
1.68
212
1741
188
1531
1.71
4.14
3.4
2.9
35.69
44.34
u/l
1.74
176
1425
59
352
1.86
4.02
3.3
2.8
0.81
0.81
mmol/l
0.01
54
323
225
1938
1.86
3.96
4.7
4.3
14.71
14.83
pmol/l
0.34
212
1754
130
973
1.63
3.90
2.4
2.0
—
—
—
0
0
46
260
1.92
3.68
2.3
2.2
5.67
6.91
umol/l
0.43
41
222
114
838
1.61
3.61
3.3
3.3
—
—
—
0
0
82
555
1.68
3.59
1.4
1.3
6.03
2.19
u/ml
0.32
15
144
252
2280
2.17
3.47
5.9
5.2
1.85
2.39
mu/l
0.50
241
2076
87
603
1.65
3.46
3.4
3.3
93.32
94.07
%
0.10
82
585
58
364
1.75
3.32
3.2
2.7
3.63
3.67
e6/l
0.01
35
180
134
1043
1.55
3.22
4.9
3.6
35.54
35.48
g/l
0.04
127
973
39
221
1.89
3.10
2.0
1.7
362.26
372.44
nmol/l
0.11
39
197
104
772
1.56
3.05
3.1
3.5
7.44
7.40
ph
—
5
142
5
5
10.15
2.99
1.4
2.4
—
—
—
0
0
6
9
6.78
2.88
1.2
1.7
115.17
118.11
nmol/l
—
6
9
55
807
0.60
2.86
3.5
2.9
—
—
—
0
0
82
589
1.56
2.74
1.6
1.5
30.03
22.27
nmol/l
0.72
72
487
7
195
0.34
2.66
3.3
3.4
—
—
—
0
0
101
765
1.50
2.63
1.8
2.3
—
—
—
0
0
134
1076
1.48
2.61
2.5
2.2
83.43
79.30
nmol/l
0.80
121
932
16
68
2.44
2.61
2.1
2.7
—
—
—
0
0
33
189
1.85
2.55
4.5
5.7
1.20
1.31
mmol/l
0.36
33
181
130
1044
1.46
2.50
2.9
2.7
137.96
96.57
ug/l
0.41
124
941
50
326
1.65
2.48
2.0
1.9
—
—
—
0
0
76
550
1.53
2.43
4.4
3.8
—
—
—
0
0
86
639
1.50
2.43
3.3
2.9
—
—
—
0
0
29
163
1.87
2.38
4.4
6.8
—
—
—
0
0
18
85
2.20
2.34
3.6
3.8
—
—
—
0
0
53
358
1.59
2.28
1.3
1.2
—
—
—
0
0
146
1213
1.43
2.27
6.3
5.5
0.17
0.18
e9/l
0.50
134
1065
135
1106
1.43
2.27
14.0
12.6
1.16
1.20
inr
0.15
27
330
29
166
1.83
2.26
1.1
1.2
—
—
—
0
0
134
1097
1.43
2.26
6.5
5.6
—
—
—
0
0
114
907
1.44
2.24
3.1
3.6
15.08
37.91
ng/l
2.27
84
630
265
2507
2.32
2.22
19.6
16.0
70.00
71.26
umol/l
0.58
265
2507
106
834
1.44
2.20
4.1
3.6
60.11
81.44
e6/l
0.31
80
576
143
1189
1.42
2.18
6.5
5.3
1.77
1.98
e9/l
0.95
133
1058
71
518
1.50
2.17
5.0
4.1
1.02
1.02
kg/l
—
7
70
254
2372
1.85
2.16
17.3
13.6
21.21
21.67
mg/l
0.08
207
1849
64
458
1.52
2.14
4.1
3.7
257.43
204.84
ng/l
0.08
55
357
25
139
1.88
2.13
2.4
2.5
—
—
—
0
0
86
657
1.45
2.07
3.4
2.9
0.14
0.59
e6/l
3.75
69
484
15
70
2.21
2.02
2.0
2.9
—
—
—
0
0
31
189
1.72
1.98
3.4
3.5
—
—
—
0
0
260
2459
1.93
1.91
15.4
12.8
—
—
—
0
0
87
676
1.42
1.90
3.0
3.0
17.66
140.62
mg/l
0.63
44
396
73
550
1.44
1.88
1.5
1.7
0.73
1.03
mg/l
1.09
58
447
8
28
2.91
1.87
2.0
3.0
13.25
13.28
%
—
8
28
81
624
1.42
1.85
8.0
7.0
—
—
—
0
0
89
699
1.40
1.82
3.0
2.9
7.09
6.61
mmol/l
0.53
78
583
77
591
1.42
1.79
4.1
3.8
—
—
—
0
0
138
1167
1.36
1.79
6.5
5.3
0.52
0.56
e9/l
1.33
127
1013
251
2358
1.69
1.78
5.1
4.6
5.77
5.90
mmol/l
0.87
235
2133
90
712
1.39
1.75
3.5
3.0
18.77
31.57
e6/l
1.13
69
536
133
1126
1.35
1.68
6.7
5.5
27.68
28.37
%
0.29
127
1048
8
31
2.63
1.67
1.1
1.4
—
—
—
0
0
35
232
1.58
1.65
2.3
2.3
39.03
28.73
u/l
0.45
30
191
191
1712
1.37
1.64
3.9
3.8
—
—
—
0
0
137
1171
1.34
1.60
6.5
5.3
0.04
0.04
e9/l
0.19
126
1016
10
44
2.32
1.57
1.6
1.8
—
—
—
0
0
64
486
1.41
1.57
1.8
1.6
1.95
2.30
g/l
1.02
30
282
25
154
1.69
1.56
2.7
3.0
3.48
5.03
e9/l
1.14
17
125
89
715
1.36
1.56
3.6
3.6
4.55
7.03
mg/mmol
0.47
48
415
74
578
1.38
1.54
2.4
2.1
2.72
3.35
mg/l
1.80
60
482
269
2602
2.17
1.53
25.7
20.5
38.98
39.65
%
0.90
247
2429
74
579
1.38
1.52
2.0
2.6
327.52
9105.86
umol/l
3.86
61
495
7
27
2.63
1.52
1.1
1.8
43.57
56.81
%
—
7
27
35
239
1.53
1.46
3.9
4.0
—
—
—
0
0
6
22
2.76
1.44
1.7
2.7
—
—
—
0
0
28
183
1.59
1.41
1.5
1.4
—
—
—
0
0
29
192
1.57
1.39
1.9
2.7
68.71
75.32
ng/l
0.29
24
167
156
1377
1.30
1.38
8.7
9.0
3.74
4.00
e9/l
0.96
150
1215
264
2538
1.86
1.38
12.1
10.3
25.22
24.03
u/l
0.40
259
2440
5
17
2.98
1.36
1.0
1.4
—
—
—
0
0
13
68
1.96
1.35
2.5
2.9
—
—
—
0
0
39
279
1.46
1.32
1.9
1.3
—
—
—
0
0
30
203
1.54
1.31
1.5
1.5
—
—
—
0
0
9
43
2.13
1.31
1.2
1.7
—
—
—
0
0
6
24
2.53
1.31
1.8
1.5
—
—
—
0
0
18
107
1.73
1.29
1.2
1.2
—
—
—
0
0
60
468
1.36
1.26
1.3
1.3
29.84
36.17
iu/ml
0.16
23
163
18
109
1.70
1.22
2.0
2.1
—
—
—
0
0
43
319
1.41
1.21
1.4
1.6
—
—
—
0
0
127
1105
1.28
1.20
7.0
5.7
8.44
8.27
%
0.27
121
1028
122
1057
1.28
1.19
6.9
5.4
0.70
0.70
%
0.01
116
972
43
320
1.41
1.19
1.3
1.4
380.00
567.23
titre
—
6
83
11
57
1.97
1.18
1.0
1.1
3.46
3.82
mmol/l
0.74
11
51
0
35
0.00
1.16
0.0
2.6
—
—
—
0
0
5
20
2.53
1.15
2.0
2.6
—
—
—
0
0
19
120
1.63
1.12
3.5
3.6
—
7.40
—
0
15
15
89
1.72
1.10
1.5
1.6
—
—
—
0
0
125
1098
1.25
1.06
6.8
5.3
2.97
2.79
%
0.47
119
1019
7
33
2.15
1.06
1.0
1.2
—
—
—
0
0
7
34
2.09
1.03
1.1
1.2
—
—
—
0
0
126
1115
1.24
0.98
6.7
5.2
56.44
57.12
%
0.26
121
1040
0
30
0.00
0.98
0.0
1.0
—
—
—
0
0
13
77
1.72
0.97
1.3
1.3
249.88
278.08
ug/g
—
8
42
17
109
1.60
0.96
12.3
7.4
—
—
—
0
0
7
37
1.91
0.94
1.6
1.2
53.48
19.00
u/l
—
7
30
7
37
1.91
0.94
1.0
1.7
—
—
—
0
0
21
143
1.51
0.93
8.0
4.4
—
—
—
0
0
53
649
0.77
0.91
3.9
3.3
—
—
—
0
0
15
95
1.61
0.89
1.1
1.1
—
—
—
0
0
6
31
1.96
0.85
1.0
1.2
—
—
—
0
0
16
105
1.56
0.83
1.7
2.3
0.58
0.68
%
1.47
16
105
245
2355
1.35
0.83
4.8
4.5
4.79
4.81
mmol/l
0.10
225
2171
25
183
1.40
0.79
2.1
3.2
63.23
73.16
e9/l
0.82
18
141
0
27
0.00
0.78
0.0
8.2
—
6.26
—
0
20
235
2252
1.29
0.77
6.7
5.7
38.87
39.52
mmol/mol
0.55
221
2090
6
34
1.78
0.77
1.0
1.0
—
—
—
0
0
7
38
1.86
0.74
1.7
1.8
—
—
—
0
0
243
2342
1.31
0.73
4.9
4.4
1.62
1.57
mmol/l
0.85
227
2141
16
109
1.50
0.72
1.7
2.3
1.14
1.13
%
0.02
16
109
92
1035
0.83
0.71
7.7
8.8
0.00
0.00
e9/l
1.22
83
843
132
1204
1.18
0.69
4.3
3.8
0.00
0.01
estimate
—
6
207
5
27
1.87
0.69
1.4
1.1
—
—
—
0
0
106
950
1.19
0.68
4.0
3.6
6.50
5.90
ph
—
8
67
69
596
1.21
0.66
1.3
1.4
—
—
—
0
0
55
465
1.23
0.65
2.8
2.7
514.82
507.00
mosm/kgh2o
0.11
50
398
10
63
1.61
0.62
1.0
1.1
—
—
—
0
0
100
898
1.18
0.62
2.9
3.1
2.34
2.36
mmol/l
0.86
85
780
9
137
0.65
0.62
2.3
1.5
—
—
—
0
0
130
1194
1.17
0.61
5.5
5.1
0.00
0.00
estimate
—
7
211
129
1185
1.17
0.60
4.3
3.8
0.00
0.00
estimate
—
7
231
0
21
0.00
0.60
0.0
1.1
—
—
—
0
0
0
21
0.00
0.60
0.0
1.1
—
—
—
0
0
12
81
1.50
0.58
3.6
4.8
—
—
—
0
0
59
510
1.20
0.56
1.6
1.7
527.57
467.46
pmol/l
0.67
51
414
13
90
1.47
0.56
1.8
1.2
—
—
—
0
0
10
65
1.56
0.56
1.1
1.2
404.70
471.10
mg/l
—
10
60
6
38
1.59
0.54
1.3
1.5
—
—
—
0
0
6
39
1.55
0.53
1.5
1.6
—
—
—
0
0
247
2403
1.26
0.53
5.6
5.1
2.74
2.82
mmol/l
0.69
229
2193
6
40
1.51
0.52
1.2
1.2
16.50
12.75
u/l
—
6
32
78
698
1.16
0.50
4.1
3.8
—
—
—
0
0
31
254
1.25
0.49
1.7
1.5
—
—
—
0
0
232
2249
1.19
0.48
4.3
4.0
1.27
1.26
mmol/l
0.09
210
2041
33
275
1.23
0.46
1.3
1.2
—
—
—
0
0
22
175
1.28
0.45
4.6
2.9
—
—
—
0
0
20
157
1.30
0.45
1.8
2.8
—
—
—
0
0
7
51
1.38
0.44
1.3
5.7
—
—
—
0
0
5
31
1.62
0.43
1.4
1.8
—
—
—
0
0
5
32
1.57
0.42
1.0
1.2
—
—
—
0
0
10
70
1.44
0.42
1.1
1.2
—
—
—
0
0
15
114
1.33
0.41
1.9
2.8
24.86
25.30
mmol/l
0.14
15
114
5
33
1.52
0.41
1.0
1.0
—
—
—
0
0
18
141
1.30
0.41
1.2
1.4
—
—
—
0
0
0
16
0.00
0.41
0.0
1.6
—
8.74
—
0
16
0
17
0.00
0.41
0.0
1.4
—
—
—
0
0
24
197
1.24
0.39
1.5
1.4
—
—
—
0
0
28
235
1.21
0.38
1.4
1.6
—
—
—
0
0
5
37
1.36
0.37
1.4
1.3
—
—
—
0
0
6
45
1.34
0.34
1.3
1.3
—
—
—
0
0
16
128
1.27
0.32
3.8
3.7
—
—
—
0
0
18
147
1.24
0.31
1.7
1.2
—
—
—
0
0
14
173
0.80
0.29
4.1
4.1
0.00
0.18
%
—
8
51
15
121
1.25
0.29
1.5
1.9
—
—
—
0
0
8
64
1.26
0.27
1.4
5.2
469.45
47.04
mg/l
—
8
48
8
64
1.26
0.27
1.4
5.2
19.64
24.46
mg/l
—
8
47
8
65
1.24
0.27
1.9
2.1
12.94
10.62
mg/l
—
8
59
34
301
1.15
0.27
2.6
2.0
21.41
21.55
%
0.02
28
254
34
301
1.15
0.27
1.2
1.2
—
—
—
0
0
5
75
0.66
0.26
1.0
1.3
—
2.35
—
0
10
14
170
0.81
0.26
4.0
4.1
0.00
1.87
%
—
7
47
31
274
1.15
0.25
1.4
1.5
—
—
—
0
0
20
170
1.19
0.25
6.1
4.6
1.39
1.92
ug/l
0.50
20
143
12
97
1.25
0.23
1.1
1.3
—
1.49
—
0
7
16
188
0.84
0.22
4.0
4.0
0.10
0.80
%
—
10
66
0
11
0.00
0.21
0.0
2.5
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
77.40
—
0
5
0
13
0.00
0.21
0.0
1.7
—
—
—
0
0
0
13
0.00
0.21
0.0
14.8
—
855.38
—
0
13
20
229
0.86
0.21
1.3
1.3
—
—
—
0
0
6
48
1.26
0.20
1.3
1.3
—
—
—
0
0
6
48
1.26
0.20
1.3
1.3
—
—
—
0
0
6
48
1.26
0.20
1.3
1.3
—
—
—
0
0
0
14
0.00
0.20
0.0
1.3
—
94.60
—
0
14
0
14
0.00
0.20
0.0
1.4
—
—
—
0
0
6
49
1.23
0.20
1.3
1.3
—
—
—
0
0
6
49
1.23
0.20
1.5
2.2
—
—
—
0
0
6
49
1.23
0.20
1.0
1.1
—
—
—
0
0
49
454
1.10
0.20
1.2
1.3
1.17
11.91
u/ml
3.76
14
175
14
164
0.85
0.19
3.9
4.2
0.22
0.62
%
—
9
50
25
223
1.13
0.19
1.3
1.4
—
—
—
0
0
50
477
1.06
0.10
1.9
1.7
1342.82
1216.48
nmol/l
0.41
37
348
11
97
1.14
0.09
1.2
1.3
—
—
—
0
0
6
56
1.07
0.08
2.5
2.6
1.15
1.45
mg/l
—
6
49
17
180
0.94
0.04
1.5
1.4
—
—
—
0
0
28
286
0.98
0.00
2.2
3.7
29.33
6.11
ug/l
0.67
18
237
15
149
1.01
0.00
1.2
1.5
—
—
—
0
0
63
633
0.99
0.00
5.4
4.0
0.00
0.00
estimate
—
7
211
10
96
1.04
0.00
1.1
1.1
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.6
—
—
—
0
0
0
7
0.00
0.00
0.0
3.0
—
1950.00
—
0
7
0
7
0.00
0.00
0.0
1.6
—
143.43
—
0
7
0
7
0.00
0.00
0.0
1.6
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
6
60
1.00
-0.00
1.0
1.1
—
53.33
—
0
6
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.0
—
—
—
0
0
7
71
0.99
-0.00
13.3
9.8
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.5
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.8
—
—
—
0
0
0
5
0.00
-0.00
0.0
4.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.2
—
19.26
—
0
5
0
8
0.00
-0.00
0.0
1.5
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
4.50
—
0
5
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0

Mortality – FinRegistry

Association

Association between endpoint L12_CUTLAXSEN and mortality.

Females

Parameter HR [95% CI] p-value
L12_CUTLAXSEN 0.901 [0.73, 1.12] 0.345
Birth year 0.992 [0.98, 1.0] 0.089

During the follow-up period (1.1.1998 — 31.12.2019), 91 out of 879 females with L12_CUTLAXSEN died.

Males

No data

Mortality risk

Mortality risk for people of age

years, who have L12_CUTLAXSEN.

N-year risk Females Males
1 0.068% No data
5 0.471% No data
10 1.246% No data
15 2.254% No data
20 3.936% No data

Relationships between endpoints

Index endpoint: L12_CUTLAXSEN – Cutis laxa senilis

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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