No definition available.
Other and unspecified hypertrophic disorders of skin
L12_HYPERTROPHICNAS
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519972 |
1. Apply sex-specific ruleNone |
519972 |
2. Check conditionsNone |
519972 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
248 |
4. Check minimum number of eventsNone |
248 |
5. Include endpointsNone |
248 |
6. Filter based on genotype QC (FinnGen only) |
232 |
Control definitions (FinnGen only)
- Control exclude
- L12_OTHERSKINSUBCUTIS
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
Similar endpoints
↥List of similar endpoints to
Other and unspecified hypertrophic disorders of skin
based on the number of shared cases.
Similar with more cases:
- Hypertrophic disorders of skin
- Other disorders of skin and subcutaneous tissue
- Diseases of the skin and subcutaneous tissue
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1556 | 1015 | 529 |
| Only index persons | 1482 | 982 | 500 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.02 | 0.03 | 0.01 |
| Only index persons | 0.03 | 0.04 | 0.02 |
| Median age at first event (years) | |||
| Whole population | 42.51 | 42.48 | 42.83 |
| Only index persons | 42.62 | 42.36 | 43.15 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 232 | 159 | 73 |
| Unadjusted period prevalence (%) | 0.05 | 0.06 | 0.03 |
| Median age at first event (years) | 50.92 | 48.02 | 57.23 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 248
- Matched controls
- 2480
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
L91.8
ICD-10 Finland
Other hypertrophic disorders of skin
+∞
164.5
139
*
L91.9
ICD-10 Finland
Hypertrophic disorder of skin, unspecified
2152.6
131.8
116
*
L91.0
ICD-10 Finland
Hypertrophic scar
268.0
62.2
61
*
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
6.0
20.6
40
77
QBE20
NOMESCO Finland
Excision and repair of scar or web of skin of trunk
108.3
18.8
20
*
TQW99
NOMESCO Finland
Other minor procedure on skin
6.4
16.6
29
50
QAE20
NOMESCO Finland
Excision and repair of scar or web of skin of head or neck
+∞
14.7
14
*
SPAT1153
SPAT
Removal of sutures
3.0
14.7
97
442
L90.5
ICD-10 Finland
Scar conditions and fibrosis of skin
45.3
14.3
17
*
QBE30
NOMESCO Finland
Excision and repair of surgical scar in trunk
73.7
12.7
14
*
QAE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin in head or neck
4.6
12.2
31
75
S18
ICPC
Laceration/cut
2.6
11.9
129
738
QBE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin of trunk
4.7
11.6
28
65
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.5
11.3
121
684
J01FF01
ATC
clindamycin; systemic
2.6
10.8
86
421
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
2.5
10.3
91
467
ZZF00
NOMESCO Finland
Graft of adipose tissue
15.4
10.1
16
11
Y83
ICD-10 Finland
Surgical operation and other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
4.2
9.7
27
70
ZZA00
NOMESCO Finland
Split skin graft
13.1
9.5
16
13
D48.5
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Skin
4.1
9.0
26
69
JN4AD
NOMESCO Finland
Body CT examination
3.4
8.3
31
99
T81.4
ICD-10 Finland
Infection following a procedure, not elsewhere classified
3.0
8.2
39
144
HAC20
NOMESCO Finland
Total mastectomy
4.8
7.8
18
40
WX402
NOMESCO Finland
General anaesthesia
2.4
7.7
62
300
E0000UV, ,
ATC
2.1
7.6
115
719
D07AD01
ATC
clobetasol; topical
2.6
7.6
49
213
TQW40
NOMESCO Finland
Remowal of suture of skin
3.6
7.5
26
79
J01DB01
ATC
cefalexin; oral
2.9
7.2
219
1791
D02AE01
ATC
carbamide; topical
3.7
7.2
23
66
SPAT1149
SPAT
Suture or treatment of traumatic wound
2.8
7.0
37
145
HA1AE
NOMESCO Finland
Ultrasound examination of mammary glands
3.2
6.8
28
95
L30.9
ICD-10 Finland
Dermatitis, unspecified
2.3
6.8
58
287
L98.4
ICD-10 Finland
Chronic ulcer of skin, not elsewhere classified
23.2
6.7
9
*
SPAT1148
SPAT
Treatment of chronic ulcer or burn
2.8
6.5
34
132
N02AX02
ATC
tramadol; systemic, rectal
2.0
6.5
106
673
J01FA06
ATC
roxithromycin; oral
2.0
6.5
107
682
R06.2
ICD-10 Finland
Wheezing
4.1
6.1
17
44
D07AC01
ATC
betamethasone; topical
2.0
6.0
92
568
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
128
769
2.37
10.14
11.1
9.5
1.06
1.19
inr
1.93
41
240
123
735
2.34
9.76
5.8
4.2
35.26
36.32
g/l
1.13
115
693
129
795
2.30
9.42
6.8
5.5
1.21
1.22
mmol/l
0.78
119
725
100
572
2.25
8.54
3.6
2.5
56.31
65.32
u/l
0.48
91
534
159
1110
2.20
8.07
5.2
4.2
6.47
6.53
mmol/l
0.14
153
1014
142
950
2.16
8.02
2.9
2.4
—
—
—
0
0
130
877
2.01
6.79
7.9
6.3
1.21
1.22
mmol/l
0.62
110
744
193
1506
2.27
6.77
5.2
3.7
11.08
10.77
mm/h
0.12
180
1387
101
627
2.03
6.62
3.2
3.2
2.34
2.35
mmol/l
0.35
86
565
36
145
2.73
6.46
5.6
2.4
0.20
0.22
g/l
1.04
36
138
158
1169
1.97
6.05
9.7
9.4
3.93
4.02
e9/l
0.21
145
1030
139
992
1.91
5.85
8.9
5.9
10.65
10.55
umol/l
0.03
134
936
18
51
3.73
5.72
3.1
2.0
10.56
11.59
mg/l
0.20
18
46
38
169
2.47
5.58
2.8
2.9
—
—
—
0
0
188
1502
2.04
5.47
10.6
6.9
82.26
73.85
u/l
1.56
177
1404
76
453
1.98
5.41
2.8
1.9
—
—
—
0
0
236
2082
3.76
5.41
17.7
11.3
23.08
20.96
mg/l
0.34
198
1594
53
282
2.12
5.11
4.0
3.0
0.83
0.82
mmol/l
0.29
53
267
73
437
1.95
5.10
2.7
2.7
746.08
666.18
ng/l
0.15
60
365
64
369
1.99
4.96
1.3
1.3
1.30
8.69
u/ml
2.59
20
147
74
449
1.92
4.95
2.4
2.4
328.12
7013.70
umol/l
2.21
65
396
64
374
1.96
4.76
1.7
1.6
458.68
453.63
pmol/l
0.05
50
325
79
512
1.80
4.21
4.9
3.4
0.00
0.00
estimate
-0.00
32
181
18
64
2.95
4.05
1.5
1.6
—
—
—
0
0
18
65
2.91
3.95
1.7
1.7
—
—
—
0
0
38
198
2.09
3.84
7.6
6.3
103.39
104.35
mmol/l
0.48
38
198
62
385
1.81
3.76
1.4
1.3
10.14
32.60
iu/ml
3.70
15
130
26
117
2.37
3.73
2.2
1.4
—
—
—
0
0
101
728
1.65
3.56
2.2
1.8
98.46
95.48
pmol/l
0.22
53
379
90
631
1.67
3.53
2.9
2.9
—
—
—
0
0
111
825
1.63
3.44
3.0
2.2
75.39
77.05
nmol/l
0.23
102
742
96
689
1.64
3.42
5.0
2.9
31.48
29.04
u/l
0.40
91
652
51
307
1.83
3.40
1.7
1.7
1418.29
1179.10
nmol/l
1.28
38
233
219
1953
2.04
3.30
5.6
4.5
1.94
1.80
mu/l
0.92
203
1806
16
61
2.73
3.20
1.4
2.1
—
—
—
0
0
229
2082
2.30
3.18
18.9
12.2
3.92
3.94
mmol/l
0.55
224
2022
37
205
1.95
3.17
8.5
5.7
—
—
—
0
0
46
275
1.83
3.13
1.5
1.7
—
—
—
0
0
11
30
3.79
3.12
1.2
1.3
—
—
—
0
0
20
87
2.41
3.10
4.3
5.7
24.77
24.83
mmol/l
0.02
20
87
102
759
1.58
3.06
4.4
3.3
—
—
—
0
0
11
31
3.66
3.03
1.2
1.3
—
—
—
0
0
11
31
3.66
3.03
1.2
1.3
—
—
—
0
0
11
31
3.66
3.03
1.2
1.3
—
—
—
0
0
11
31
3.66
3.03
1.2
1.3
—
—
—
0
0
11
31
3.66
3.03
1.2
1.2
—
—
—
0
0
5
5
10.17
2.99
1.0
1.2
—
—
—
0
0
5
5
10.17
2.99
1.0
1.2
—
—
—
0
0
90
658
1.58
2.88
4.1
3.0
43.37
26.84
ng/l
0.48
62
402
125
987
1.54
2.82
4.4
3.3
0.00
0.00
estimate
-0.00
34
179
32
176
1.94
2.80
2.7
4.7
2.81
6.39
ug/l
1.39
22
138
5
6
8.47
2.76
1.0
1.3
—
—
—
0
0
5
6
8.47
2.76
1.0
1.3
—
—
—
0
0
6
10
6.12
2.71
1.0
1.4
—
—
—
0
0
14
55
2.64
2.66
1.5
1.3
242.71
318.08
ug/g
—
7
30
13
50
2.69
2.57
1.2
1.3
—
—
—
0
0
38
228
1.79
2.55
5.0
4.2
30.88
31.91
%
0.21
26
153
122
975
1.49
2.51
4.4
3.3
0.00
0.00
estimate
-0.00
34
198
10
32
3.21
2.46
1.9
1.3
—
—
—
0
0
168
1439
1.52
2.43
4.4
2.8
62.67
40.77
u/l
1.37
158
1369
11
39
2.90
2.37
1.2
1.1
—
—
—
0
0
236
2211
2.39
2.37
14.1
8.9
26.83
25.53
u/l
0.62
229
2140
7
18
3.97
2.27
1.1
2.0
—
18.61
—
0
7
16
73
2.27
2.26
1.9
2.6
23.39
24.33
mmol/l
0.85
16
73
120
972
1.45
2.22
5.4
4.6
0.00
0.00
estimate
-0.00
32
189
224
2071
1.84
2.17
5.0
4.3
2.83
2.83
mmol/l
0.01
205
1930
30
178
1.78
2.10
9.1
9.7
4.98
5.14
kpa
0.37
30
169
30
178
1.78
2.10
9.1
9.7
13.94
12.37
kpa
0.47
30
170
203
1836
1.58
2.06
6.0
4.8
38.38
38.70
mmol/mol
0.21
186
1724
15
70
2.22
2.03
2.0
3.1
47.37
52.64
%
0.34
15
70
117
958
1.42
1.98
3.0
2.6
97.34
100.19
ug/l
0.06
108
888
68
503
1.48
1.97
2.6
2.7
0.16
0.39
e6/l
1.49
56
380
30
182
1.74
1.96
9.0
9.5
1.50
1.52
mmol/l
0.01
25
140
11
45
2.51
1.96
1.2
1.2
—
—
—
0
0
221
2048
1.73
1.95
4.8
4.0
4.79
4.74
mmol/l
0.24
204
1917
11
46
2.46
1.88
1.2
1.2
—
—
—
0
0
61
447
1.48
1.84
1.7
1.6
0.96
0.98
mg/l
0.02
43
340
8
29
2.82
1.80
1.0
1.1
—
—
—
0
0
8
29
2.82
1.80
1.1
1.3
—
—
—
0
0
8
29
2.82
1.80
1.1
1.3
—
—
—
0
0
33
211
1.65
1.79
2.6
1.9
23.30
24.05
%
0.10
28
177
219
2034
1.66
1.79
4.6
3.9
1.48
1.50
mmol/l
0.25
202
1898
25
149
1.75
1.75
2.6
2.5
77.00
69.48
ml/min/173m2
0.90
11
60
8
30
2.72
1.74
1.6
2.7
55.38
56.77
%
—
8
30
182
1633
1.43
1.70
4.8
3.9
14.69
14.50
pmol/l
0.55
160
1493
14
70
2.06
1.62
1.5
1.3
—
—
—
0
0
5
14
3.62
1.62
1.2
1.4
—
—
—
0
0
16
85
1.94
1.59
1.3
1.7
—
—
—
0
0
67
515
1.41
1.57
3.9
3.5
3.09
11.85
mg/mmol
2.30
47
301
19
108
1.82
1.55
10.9
11.0
24.24
24.99
mmol/l
0.31
19
101
5
16
3.17
1.44
1.2
1.2
—
—
—
0
0
9
40
2.30
1.41
1.3
1.3
—
—
—
0
0
22
135
1.69
1.41
4.0
3.3
1.22
1.22
mmol/l
0.11
22
114
24
151
1.65
1.41
10.8
10.8
117.42
121.84
g/l
0.49
24
145
57
434
1.41
1.40
1.6
1.4
—
—
—
0
0
9
41
2.24
1.38
1.2
1.5
—
—
—
0
0
5
17
2.98
1.36
1.2
1.3
—
—
—
0
0
5
17
2.98
1.36
1.2
1.3
—
—
—
0
0
5
17
2.98
1.36
1.0
1.1
—
—
—
0
0
5
17
2.98
1.36
1.2
1.3
—
—
—
0
0
5
17
2.98
1.36
1.0
1.5
—
—
—
0
0
5
17
2.98
1.36
1.0
1.5
—
—
—
0
0
210
1961
1.46
1.35
4.5
3.6
1.29
1.26
mmol/l
0.22
191
1822
17
99
1.77
1.31
1.8
2.7
135.12
130.94
g/l
0.36
17
99
15
84
1.84
1.30
1.6
2.1
0.61
0.64
%
0.12
15
84
12
63
1.95
1.25
1.9
2.8
1.09
1.34
g/l
0.59
12
56
12
63
1.95
1.25
4.3
12.8
1.68
1.56
%
0.24
12
56
43
319
1.42
1.22
1.9
2.9
2.44
2.44
mmol/l
0.03
36
281
53
411
1.37
1.17
1.7
1.5
22.69
20.62
nmol/l
0.38
40
351
209
1964
1.41
1.16
13.2
10.3
87.76
86.81
ml/min/173m2
0.24
185
1593
14
80
1.79
1.15
1.7
1.6
—
—
—
0
0
57
450
1.35
1.13
2.7
1.9
2.88
2.82
mg/l
0.08
45
383
39
290
1.41
1.10
2.4
2.5
0.47
1.10
e6/l
2.31
29
162
63
511
1.31
1.04
1.3
1.2
0.52
1.90
u/ml
0.92
11
135
169
1553
1.28
1.00
3.2
3.5
—
—
—
0
0
14
84
1.71
1.00
1.5
1.3
—
—
—
0
0
5
23
2.20
0.98
1.4
1.3
—
—
—
0
0
9
50
1.83
0.97
8.6
2.6
—
—
—
0
0
7
37
1.92
0.95
1.4
1.2
—
—
—
0
0
6
27
2.25
0.94
1.0
1.2
—
—
—
0
0
210
1992
1.35
0.94
5.1
3.9
5.72
5.83
mmol/l
0.85
184
1835
12
71
1.73
0.90
1.2
1.1
—
—
—
0
0
6
29
2.09
0.90
1.7
1.4
—
—
—
0
0
6
29
2.09
0.90
1.3
1.3
—
—
—
0
0
11
64
1.75
0.87
2.1
1.5
—
—
—
0
0
6
34
1.78
0.77
1.3
1.5
—
—
—
0
0
5
25
2.02
0.73
1.8
3.4
42.00
74.60
u/ml
—
5
25
7
40
1.77
0.72
1.1
1.1
—
—
—
0
0
17
118
1.47
0.71
2.2
2.4
199.54
3254.16
u/l
—
5
50
5
27
1.87
0.69
1.6
1.2
—
—
—
0
0
5
27
1.87
0.69
2.0
1.6
5.06
6.92
u/ml
—
5
27
7
44
1.61
0.65
1.6
1.6
—
—
—
0
0
14
95
1.50
0.65
1.2
1.4
189.17
258.59
miu/ml
—
6
47
25
191
1.34
0.64
1.3
1.7
—
—
—
0
0
0
20
0.00
0.60
0.0
1.1
—
—
—
0
0
0
21
0.00
0.60
0.0
2.0
—
—
—
0
0
0
21
0.00
0.60
0.0
1.1
—
—
—
0
0
10
64
1.59
0.59
1.4
1.4
—
—
—
0
0
24
185
1.33
0.59
1.4
1.7
—
—
—
0
0
41
341
1.24
0.57
2.5
3.2
166.75
219.16
ng/l
0.12
24
231
6
37
1.64
0.56
1.5
1.9
—
—
—
0
0
11
75
1.49
0.51
1.6
1.6
—
—
—
0
0
10
67
1.51
0.50
1.0
1.4
—
—
—
0
0
27
218
1.27
0.49
1.5
1.6
—
—
—
0
0
22
173
1.30
0.48
2.3
2.3
51.00
29.89
u/l
0.42
17
146
34
284
1.23
0.47
1.6
1.8
1.37
1.37
%
0.01
28
253
10
70
1.45
0.42
1.2
1.1
—
—
—
0
0
0
16
0.00
0.41
0.0
1.0
—
—
—
0
0
10
71
1.43
0.40
1.2
1.1
—
—
—
0
0
0
19
0.00
0.39
0.0
1.4
—
—
—
0
0
62
559
1.15
0.37
1.7
1.6
1.44
1.37
mmol/l
0.24
53
483
5
37
1.36
0.37
1.0
1.3
—
—
—
0
0
5
37
1.36
0.37
1.0
1.3
—
—
—
0
0
9
70
1.30
0.37
1.2
1.7
—
—
—
0
0
55
493
1.15
0.36
1.9
1.6
—
—
—
0
0
15
118
1.29
0.34
2.9
2.5
50.20
59.47
u/ml
0.08
15
113
42
373
1.15
0.32
1.9
2.3
—
—
—
0
0
15
185
0.80
0.31
1.5
1.4
—
—
—
0
0
15
122
1.24
0.27
1.1
1.0
—
—
—
0
0
49
445
1.13
0.27
6.4
4.7
1.70
2.54
ug/l
0.53
43
400
12
95
1.28
0.27
1.8
1.9
—
—
—
0
0
20
169
1.20
0.27
1.5
1.8
—
—
—
0
0
31
273
1.15
0.26
2.6
2.6
4.25
3.10
e6/l
0.25
21
147
5
40
1.26
0.22
2.0
1.3
—
—
—
0
0
5
42
1.19
0.21
1.0
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
2.3
—
—
—
0
0
0
10
0.00
0.21
0.0
2.3
—
—
—
0
0
0
14
0.00
0.20
0.0
3.1
—
—
—
0
0
25
224
1.13
0.18
1.6
1.9
—
—
—
0
0
12
101
1.20
0.17
1.9
1.3
—
—
—
0
0
38
353
1.09
0.15
5.0
4.0
22.61
21.88
%
0.09
17
150
10
88
1.14
0.08
1.8
1.5
—
—
—
0
0
7
65
1.08
0.08
1.3
1.0
—
10.32
—
0
12
36
345
1.05
0.06
1.8
2.1
—
—
—
0
0
11
104
1.06
0.01
1.5
1.8
—
—
—
0
0
18
174
1.04
0.00
1.4
1.2
32.98
182.21
iu/ml
—
10
70
27
266
1.02
0.00
3.2
2.8
0.62
0.67
ug/l
0.19
18
162
0
6
0.00
-0.00
0.0
1.3
—
—
—
0
0
14
140
1.00
-0.00
1.1
1.3
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
8.83
—
0
7
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
2.2
—
12.24
—
0
9
0
5
0.00
-0.00
0.0
3.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.0
—
17.21
—
0
9
0
6
0.00
-0.00
0.0
1.5
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
9
98
0.92
-0.00
1.6
1.5
260.56
287.48
mu/l
—
9
86
0
9
0.00
-0.00
0.0
2.9
—
—
—
0
0
0
9
0.00
-0.00
0.0
2.9
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint L12_HYPERTROPHICNAS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_HYPERTROPHICNAS | 1.269 [0.91, 1.77] | 0.16 |
| Birth year | 0.991 [0.98, 1.0] | 0.048 |
During the follow-up period (1.1.1998 — 31.12.2019), 57 out of 816 females with L12_HYPERTROPHICNAS died.
Males
No dataMortality risk
Mortality risk for people of age
years, who have L12_HYPERTROPHICNAS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.101% | No data |
| 5 | 0.661% | No data |
| 10 | 1.736% | No data |
| 15 | 3.21% | No data |
| 20 | 5.77% | No data |
Relationships between endpoints
↥Index endpoint: L12_HYPERTROPHICNAS – Other and unspecified hypertrophic disorders of skin
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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