No definition available.
Other and unspecified hypertrophic disorders of skin
L12_HYPERTROPHICNAS
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
231 |
4. Check minimum number of eventsNone |
231 |
5. Include endpointsNone |
231 |
6. Filter based on genotype QC (FinnGen only) |
231 |
Control definitions (FinnGen only)
- Control exclude
- L12_OTHERSKINSUBCUTIS
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
Similar endpoints
↥List of similar endpoints to
Other and unspecified hypertrophic disorders of skin
based on the number of shared cases.
Similar with more cases:
- Hypertrophic disorders of skin
- Other disorders of skin and subcutaneous tissue
- Diseases of the skin and subcutaneous tissue
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1556 | 1015 | 529 |
| Only index persons | 1482 | 982 | 500 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.02 | 0.03 | 0.01 |
| Only index persons | 0.03 | 0.04 | 0.02 |
| Median age at first event (years) | |||
| Whole population | 42.51 | 42.48 | 42.83 |
| Only index persons | 42.62 | 42.36 | 43.15 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 231 | 164 | 67 |
| Unadjusted period prevalence (%) | 0.05 | 0.06 | 0.03 |
| Median age at first event (years) | 48.16 | 44.78 | 56.43 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 200
- Matched controls
- 2001
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
L91.8
ICD-10 Finland
Other hypertrophic disorders of skin
+∞
128.4
109
*
L91.9
ICD-10 Finland
Hypertrophic disorder of skin, unspecified
+∞
113.7
98
*
L91.0
ICD-10 Finland
Hypertrophic scar
220.6
50.5
50
*
QBE20
NOMESCO Finland
Excision and repair of scar or web of skin of trunk
98.4
16.8
18
*
ZZF00
NOMESCO Finland
Graft of adipose tissue
49.9
12.0
14
*
L90.5
ICD-10 Finland
Scar conditions and fibrosis of skin
127.0
11.6
12
*
TQW99
NOMESCO Finland
Other minor procedure on skin
9.5
11.4
23
27
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
5.9
10.7
30
58
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.7
10.1
99
534
QBE30
NOMESCO Finland
Excision and repair of surgical scar in trunk
+∞
9.4
9
*
S18
ICPC
Laceration/cut
2.4
8.0
94
537
ZZA00
NOMESCO Finland
Split skin graft
10.0
7.9
15
16
QAE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin in head or neck
4.7
7.8
26
62
QAA25
NOMESCO Finland
Destruction of lesion of head or neck
26.2
7.6
10
*
J01DB01
ATC
cefalexin; oral
3.0
7.5
176
1416
QAE20
NOMESCO Finland
Excision and repair of scar or web of skin of head or neck
83.0
7.5
8
*
QBE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin of trunk
5.1
7.3
22
47
E0000UV
ATC
NA
2.3
7.1
95
570
SPAT1153
SPAT
Removal of sutures
2.4
7.0
76
412
J01FF01
ATC
clindamycin; systemic
2.4
6.8
70
369
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
2.4
6.7
69
364
SPAT1149
SPAT
Suture or treatment of traumatic wound
3.1
6.0
33
118
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
116
685
2.39
9.64
6.0
4.3
35.2
36.3
g/l
1.17
110
642
120
732
2.33
9.10
7.1
5.8
1.2
1.2
mmol/l
1.15
109
662
152
1030
2.39
8.96
5.3
4.3
6.5
6.5
mmol/l
0.21
146
936
95
541
2.28
8.29
3.7
2.5
57.6
55.3
u/l
0.21
86
502
135
890
2.24
8.21
4.7
4.0
—
—
—
0
0
121
812
2.03
6.49
8.3
6.6
1.2
1.2
mmol/l
0.85
100
682
38
158
2.68
6.45
2.8
2.9
—
—
—
0
0
150
1093
2.06
6.33
9.9
9.6
4.0
4.0
e9/l
0.16
137
961
95
590
2.04
6.27
3.3
3.2
2.3
2.4
mmol/l
0.37
80
526
180
1413
2.24
6.13
5.2
3.6
11.3
10.8
mm/h
0.19
167
1297
18
49
3.90
6.05
3.1
2.0
10.6
11.4
mg/l
0.16
18
44
73
417
2.10
6.00
2.8
2.0
—
—
—
0
0
131
923
1.97
5.93
9.1
5.9
10.6
10.6
umol/l
0.01
126
874
52
266
2.23
5.61
4.0
3.1
0.8
0.8
mmol/l
0.35
52
251
32
131
2.67
5.58
6.1
2.5
0.2
0.2
g/l
1.21
32
124
177
1402
2.12
5.56
10.8
6.8
82.4
73.7
u/l
1.52
167
1306
220
1938
3.84
5.16
18.3
11.3
23.2
20.9
mg/l
0.36
183
1481
69
406
2.00
5.13
2.5
2.8
790.0
632.0
ng/l
0.33
56
340
61
348
2.02
4.92
1.7
1.6
471.3
462.6
pmol/l
0.09
47
304
26
110
2.54
4.25
2.2
1.4
—
—
—
0
0
11
28
4.08
4.02
1.2
1.3
—
—
—
0
0
11
29
3.93
3.85
1.2
1.3
—
—
—
0
0
11
29
3.93
3.85
1.2
1.3
—
—
—
0
0
11
29
3.93
3.85
1.2
1.3
—
—
—
0
0
11
29
3.93
3.85
1.2
1.3
—
—
—
0
0
11
29
3.93
3.85
1.2
1.2
—
—
—
0
0
74
485
1.77
3.80
4.9
3.6
0.0
0.0
estimate
0.00
31
170
86
590
1.73
3.76
2.9
2.9
—
—
—
0
0
20
79
2.68
3.74
4.3
6.2
24.8
24.9
mmol/l
0.08
20
79
36
186
2.11
3.74
7.9
6.5
103.8
104.4
mmol/l
0.27
36
180
66
423
1.78
3.64
2.4
2.5
328.1
7580.4
umol/l
2.21
57
365
57
352
1.82
3.54
1.2
1.2
1.3
8.7
u/ml
2.44
18
136
16
58
2.89
3.50
1.4
2.3
—
—
—
0
0
87
612
1.68
3.41
4.1
3.1
44.5
27.6
ng/l
0.48
60
372
215
1944
2.53
3.36
19.4
12.3
3.9
3.9
mmol/l
0.75
210
1883
103
769
1.61
3.13
3.1
2.2
74.9
76.8
nmol/l
0.26
94
691
16
62
2.70
3.11
1.6
1.6
—
—
—
0
0
35
192
1.97
3.10
8.8
5.5
—
—
—
0
0
10
29
3.56
3.08
1.9
1.3
—
—
—
0
0
16
63
2.65
3.03
1.8
1.7
—
—
—
0
0
5
5
10.18
2.99
1.0
1.2
—
—
—
0
0
5
5
10.18
2.99
1.0
1.2
—
—
—
0
0
13
47
2.87
2.86
1.2
1.3
—
—
—
0
0
5
6
8.48
2.76
1.0
1.3
—
—
—
0
0
5
6
8.48
2.76
1.0
1.3
—
—
—
0
0
203
1825
1.93
2.74
5.7
4.5
2.0
1.8
mu/l
1.08
188
1688
43
263
1.78
2.73
1.6
1.7
—
—
—
0
0
11
37
3.07
2.73
1.2
1.1
—
—
—
0
0
6
10
6.12
2.71
1.0
1.4
—
—
—
0
0
55
362
1.68
2.70
1.3
1.3
10.5
30.1
iu/ml
3.07
13
119
221
2055
2.74
2.67
14.3
9.0
26.6
25.1
u/l
0.76
214
1988
46
290
1.73
2.64
1.8
1.6
1413.0
1188.3
nmol/l
1.12
34
220
30
166
1.93
2.60
2.3
4.5
2.9
5.8
ug/l
1.10
20
130
90
677
1.54
2.53
2.3
1.8
100.1
94.8
pmol/l
0.41
49
355
30
168
1.90
2.51
9.1
10.0
13.9
12.4
kpa
0.47
30
160
30
168
1.90
2.51
9.1
10.0
5.0
5.1
kpa
0.26
30
159
94
718
1.52
2.45
4.5
3.4
—
—
—
0
0
25
134
1.97
2.38
3.5
3.2
1.9
1.9
mmol/l
0.03
20
102
7
17
4.21
2.38
1.1
2.1
—
18.6
—
0
7
116
930
1.50
2.38
4.5
3.4
0.0
0.0
estimate
0.00
33
169
30
172
1.86
2.35
9.0
9.8
1.5
1.5
mmol/l
0.02
25
130
35
211
1.78
2.34
4.8
4.1
30.4
31.7
%
0.24
23
139
28
162
1.83
2.14
12.4
19.3
1.1
1.3
inr
—
8
31
113
915
1.46
2.13
4.4
3.3
0.0
0.0
estimate
0.00
33
174
191
1721
1.63
2.12
5.9
4.8
38.2
38.7
mmol/mol
0.29
174
1619
209
1930
1.87
2.10
5.1
4.3
2.8
2.8
mmol/l
0.16
190
1796
15
69
2.26
2.09
2.0
2.7
23.4
24.3
mmol/l
0.78
15
69
8
26
3.15
2.03
1.0
1.1
—
—
—
0
0
207
1910
1.81
2.03
4.8
3.9
4.8
4.7
mmol/l
0.38
190
1786
110
892
1.45
2.03
3.0
2.7
100.1
98.5
ug/l
0.03
101
828
205
1895
1.73
1.88
4.6
3.9
1.5
1.5
mmol/l
0.27
188
1768
154
1341
1.45
1.87
4.6
2.8
64.9
40.8
u/l
1.40
145
1276
64
474
1.48
1.86
2.7
2.8
0.2
0.4
e6/l
1.24
51
362
22
124
1.86
1.83
4.0
3.5
1.2
1.2
mmol/l
0.04
22
106
14
67
2.16
1.80
2.1
3.1
49.4
51.2
%
0.09
14
67
111
916
1.41
1.80
5.5
4.7
0.0
0.0
estimate
0.00
31
178
19
103
1.92
1.78
10.9
11.4
24.2
24.9
mmol/l
0.24
19
95
171
1526
1.46
1.76
4.9
3.9
14.7
14.5
pmol/l
0.56
150
1395
31
197
1.66
1.74
2.6
2.1
23.3
24.4
%
0.14
26
164
24
142
1.77
1.72
10.8
11.2
117.4
121.6
g/l
0.45
24
134
10
42
2.44
1.70
1.2
1.2
—
—
—
0
0
10
42
2.44
1.70
1.2
1.2
—
—
—
0
0
21
120
1.83
1.69
7.6
6.4
1.3
1.3
mmol/l
0.08
21
114
56
413
1.47
1.66
1.6
1.4
—
—
—
0
0
13
63
2.13
1.63
1.5
1.4
—
—
—
0
0
5
14
3.63
1.62
1.4
1.4
—
—
—
0
0
5
14
3.63
1.62
1.2
1.2
—
—
—
0
0
5
15
3.38
1.53
1.2
1.3
—
—
—
0
0
5
15
3.38
1.53
1.2
1.3
—
—
—
0
0
5
15
3.38
1.53
1.2
1.3
—
—
—
0
0
56
421
1.44
1.50
1.7
1.6
1.0
1.0
mg/l
0.04
38
321
9
37
2.49
1.49
1.3
1.3
—
—
—
0
0
9
38
2.42
1.47
1.2
1.5
—
—
—
0
0
5
16
3.17
1.44
1.0
1.1
—
—
—
0
0
14
74
1.95
1.42
1.7
1.6
—
—
—
0
0
6
23
2.65
1.37
1.0
1.2
—
—
—
0
0
16
90
1.84
1.37
1.8
2.8
134.9
129.7
g/l
0.43
16
90
196
1828
1.48
1.31
4.5
3.5
1.3
1.3
mmol/l
0.14
178
1700
54
416
1.39
1.26
2.7
2.0
3.0
2.8
mg/l
0.21
42
352
6
25
2.44
1.25
1.7
1.4
—
—
—
0
0
9
45
2.04
1.24
8.6
2.4
—
—
—
0
0
195
1822
1.45
1.24
13.6
10.4
87.9
86.6
ml/min/173m2
0.34
174
1468
60
475
1.36
1.18
1.3
1.2
0.5
2.0
u/ml
0.92
11
124
37
273
1.42
1.10
2.5
2.5
0.4
1.1
e6/l
2.44
27
158
14
82
1.75
1.08
1.4
1.7
—
—
—
0
0
7
33
2.16
1.06
1.4
1.3
—
—
—
0
0
5
22
2.30
1.04
1.4
1.3
—
—
—
0
0
197
1860
1.40
1.02
5.1
3.9
5.7
5.8
mmol/l
1.05
171
1714
7
35
2.03
1.01
1.1
1.1
—
—
—
0
0
21
141
1.54
0.99
2.6
2.6
77.0
68.0
ml/min/173m2
1.10
11
57
13
78
1.71
0.93
1.5
1.3
—
—
—
0
0
157
1444
1.27
0.93
3.1
3.4
—
—
—
0
0
6
28
2.17
0.92
1.3
1.3
—
—
—
0
0
11
63
1.78
0.92
2.0
2.8
1.1
1.4
g/l
0.64
11
55
39
302
1.35
0.89
1.9
2.8
2.4
2.4
mmol/l
0.04
33
264
11
64
1.75
0.88
1.2
1.1
—
—
—
0
0
193
1828
1.34
0.87
16.6
12.6
38.9
40.1
%
0.93
137
1431
12
72
1.70
0.87
11.4
9.2
24.3
24.6
mmol/l
0.16
12
65
17
116
1.50
0.76
2.2
2.4
199.5
3320.1
u/l
—
5
49
5
25
2.02
0.73
1.6
1.2
—
—
—
0
0
47
387
1.27
0.71
1.8
1.5
22.2
20.6
nmol/l
0.26
36
330
33
261
1.31
0.67
1.6
1.7
1.4
1.4
%
0.17
27
232
7
43
1.65
0.67
1.6
1.5
—
—
—
0
0
10
62
1.64
0.66
1.0
1.4
—
—
—
0
0
14
95
1.50
0.65
1.2
1.4
189.2
256.1
miu/ml
—
6
47
24
182
1.36
0.64
1.3
1.7
—
—
—
0
0
39
318
1.27
0.64
2.5
3.3
181.0
207.9
ng/l
0.05
22
215
10
63
1.61
0.63
1.4
1.4
—
—
—
0
0
23
176
1.34
0.59
1.4
1.7
—
—
—
0
0
9
60
1.52
0.55
2.3
1.5
—
—
—
0
0
6
38
1.59
0.54
1.5
1.9
—
—
—
0
0
53
459
1.20
0.51
1.9
1.6
—
—
—
0
0
10
68
1.49
0.47
5.7
3.6
24.8
24.4
mmol/l
—
10
62
41
352
1.20
0.44
2.0
2.3
—
—
—
0
0
58
514
1.17
0.44
1.7
1.6
1.4
1.4
mmol/l
0.25
49
445
5
31
1.63
0.43
1.4
1.4
—
—
—
0
0
0
16
0.00
0.41
0.0
1.0
—
—
—
0
0
0
17
0.00
0.41
0.0
1.1
—
—
—
0
0
0
18
0.00
0.40
0.0
1.1
—
—
—
0
0
0
19
0.00
0.39
0.0
1.4
—
—
—
0
0
0
19
0.00
0.39
0.0
1.3
—
—
—
0
0
9
67
1.36
0.38
1.2
1.6
—
—
—
0
0
14
180
0.76
0.38
1.5
1.5
—
—
—
0
0
5
36
1.40
0.38
1.0
1.3
—
—
—
0
0
5
36
1.40
0.38
1.0
1.3
—
—
—
0
0
24
198
1.24
0.38
1.5
1.5
—
—
—
0
0
9
70
1.30
0.37
1.2
1.1
—
—
—
0
0
20
162
1.26
0.37
2.3
2.3
55.7
30.1
u/l
0.46
15
138
30
255
1.20
0.36
2.7
2.7
4.5
3.2
e6/l
0.27
20
142
9
71
1.28
0.36
1.2
1.1
—
—
—
0
0
10
73
1.39
0.35
1.6
1.6
—
—
—
0
0
45
408
1.13
0.26
6.8
4.7
1.8
2.6
ug/l
0.47
40
367
14
115
1.23
0.24
1.1
1.0
—
—
—
0
0
12
97
1.25
0.23
1.9
1.4
—
—
—
0
0
5
39
1.29
0.23
1.0
1.1
—
—
—
0
0
5
40
1.26
0.22
2.0
1.3
—
—
—
0
0
0
10
0.00
0.21
0.0
2.3
—
—
—
0
0
0
10
0.00
0.21
0.0
2.3
—
—
—
0
0
0
14
0.00
0.20
0.0
3.1
—
—
—
0
0
11
90
1.23
0.19
1.8
1.9
—
—
—
0
0
19
166
1.16
0.18
1.5
1.8
—
—
—
0
0
7
60
1.17
0.18
1.3
1.0
—
10.4
—
0
10
24
215
1.13
0.17
1.6
2.0
—
—
—
0
0
12
138
0.86
0.13
1.2
1.3
—
—
—
0
0
35
326
1.09
0.13
1.9
2.1
—
—
—
0
0
10
85
1.18
0.12
1.8
1.6
—
—
—
0
0
18
162
1.12
0.12
1.4
1.2
33.0
185.1
iu/ml
—
10
66
23
246
0.93
0.08
3.5
2.9
0.6
0.7
ug/l
0.07
17
153
34
325
1.05
0.06
5.3
4.1
22.6
22.0
%
0.08
17
141
11
101
1.09
0.04
1.5
1.8
—
—
—
0
0
10
101
0.99
0.00
1.8
1.8
1.8
2.3
mg/l
—
10
71
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
0
9
0.00
0.00
0.0
2.9
—
—
—
0
0
0
7
0.00
0.00
0.0
1.6
—
—
—
0
0
0
9
0.00
0.00
0.0
2.2
—
12.2
—
0
9
0
7
0.00
0.00
0.0
1.4
—
—
—
0
0
0
9
0.00
0.00
0.0
2.9
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.1
—
8.8
—
0
7
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
9
91
0.99
0.00
1.6
1.5
260.6
283.9
mu/l
—
9
81
0
8
0.00
0.00
0.0
1.0
—
18.5
—
0
8
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint L12_HYPERTROPHICNAS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_HYPERTROPHICNAS | 1.269 [0.91, 1.77] | 0.16 |
| Birth year | 0.991 [0.98, 1.0] | 0.048 |
During the follow-up period (1.1.1998 — 31.12.2019), 57 out of 816 females with L12_HYPERTROPHICNAS died.
Males
No dataMortality risk
Mortality risk for people of age
years, who have L12_HYPERTROPHICNAS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.101% | No data |
| 5 | 0.661% | No data |
| 10 | 1.736% | No data |
| 15 | 3.21% | No data |
| 20 | 5.77% | No data |
Relationships between endpoints
↥Index endpoint: L12_HYPERTROPHICNAS – Other and unspecified hypertrophic disorders of skin
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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