spondyloarthropathy: A group of inflammatory rheumatic diseases associated with arthritis and enthesitis, and often involving the axial skeleton. The most common form of spondyloarthritis is ankylosing spondylitis. Other forms include axial spondyloarthritis, peripheral spondyloarthritis, reactive arthritis, psoriatic arthritis/spondylitis and enteropathic arthritis/spondylitis.
Spondylopathies in diseases classified elsewhere
DOID EFO Endpoint Browser PheWeb
M13_SPONDYLOPATHINOTH
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519972 |
1. Apply sex-specific ruleNone |
519972 |
2. Check conditionsNone |
519972 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
443 |
4. Check minimum number of eventsNone |
443 |
5. Include endpointsNone |
443 |
6. Filter based on genotype QC (FinnGen only) |
424 |
Control definitions (FinnGen only)
- Control exclude
- M13_DORSOPATHY
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
Similar endpoints
↥List of similar endpoints to
Spondylopathies in diseases classified elsewhere
based on the number of shared cases.
Similar with more cases:
- Spondylopathies
- Dorsopathies
- Diseases of the musculoskeletal system and connective tissue
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 2934 | 1388 | 1517 |
| Only index persons | 2404 | 1175 | 1229 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.04 | 0.04 | 0.04 |
| Only index persons | 0.05 | 0.04 | 0.05 |
| Median age at first event (years) | |||
| Whole population | 67.32 | 67.49 | 67.19 |
| Only index persons | 67.27 | 67.47 | 67.08 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 424 | 191 | 233 |
| Unadjusted period prevalence (%) | 0.09 | 0.07 | 0.11 |
| Median age at first event (years) | 69.06 | 66.22 | 71.39 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 443
- Matched controls
- 4430
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
C79.5
ICD-10 Finland
Secondary malignant neoplasm of bone and bone marrow
66.0
280.8
161
38
M49.5*C79.5
ICD-10 Finland
Metastatic fracture of vertebra
+∞
274.5
234
*
WF049
NOMESCO Finland
Radiotherapy of metastasis
39.6
271.9
184
78
N02AA05
ATC
oxycodone; systemic
13.9
180.1
281
492
C90.0
ICD-10 Finland
Multiple myeloma
70.9
156.3
86
15
H02AB02
ATC
dexamethasone; systemic
11.3
142.9
209
325
M05BX04
ATC
denosumab; parenteral
16.7
140.4
134
112
M48.0
ICD-10 Finland
Spinal stenosis
41.1
130.2
81
24
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
19.4
129.2
110
74
9732/3-C42.1
ICD-O-3
Plasma cell myeloma of bone marrow
59.5
116.4
66
13
NA3BG
NOMESCO Finland
Lumbar spine MRI examination with high intensity magnet
27.5
99.3
70
30
N02AB03
ATC
fentanyl; nasal, sublingual, transdermal
12.5
94.6
104
106
NA2AA
NOMESCO Finland
Thoracal spine X-ray examination without contrast
27.5
93.9
66
28
N03AX16
ATC
[U] pregabalin
7.4
90.3
178
367
M51.1
ICD-10 Finland
Lumbar and other intervertebral disc disorders with radiculopathy
27.1
83.7
59
25
Z51.5
ICD-10 Finland
Palliative care
7.8
79.6
135
235
WD305
NOMESCO Finland
Simple therapy of methastized malignancy with biomodifiers
32.3
74.3
49
17
117
Kela drug reimbursment
Leukaemia and other malignant diseases of the blood and bone marrow, and malignant diseases of the lymphatic tissue
10.0
74.2
95
118
M49.5*C90.0
ICD-10 Finland
Vertebral fracture due to multiple myeloma
+∞
74.1
69
*
WF004
NOMESCO Finland
Palliative radiotherapy
17.2
74.0
64
43
A04AA01
ATC
ondansetron; systemic, rectal
7.9
73.5
120
199
NA3AD
NOMESCO Finland
Lumbar spine and sacrum CT examination
34.9
73.0
47
15
NA7DG
NOMESCO Finland
Spine and spinal cord very extensive MRI examination with high intensity magnet
44.3
73.0
44
11
A03FA01
ATC
metoclopramide; systemic, rectal
5.5
69.4
210
623
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
5.3
66.6
274
1037
XX3DW
NOMESCO Finland
Time consuming IT work
6.2
65.4
141
308
WD105
NOMESCO Finland
Cystostatic therapy of methastized malignancy
10.3
65.4
80
93
N03AX12
ATC
[U] gabapentin; oral
7.0
64.8
119
222
153
Kela drug reimbursment
Lenalidomid
128.9
62.8
66
6
L04AX04
ATC
lenalidomide; oral
117.6
57.5
61
6
JN4AD
NOMESCO Finland
Body CT examination
5.8
56.5
130
298
M54.9
ICD-10 Finland
Dorsalgia, unspecified
8.2
55.8
82
119
WD505
NOMESCO Finland
Simple enzyme inhibitor or similar therapy of methastized malignancy
24.3
55.0
40
18
C79.8
ICD-10 Finland
Secondary malignant neoplasm of other specified sites
8.9
53.9
73
96
NA1AA
NOMESCO Finland
Cervical spine X-ray examination without contrast
18.7
53.8
44
26
M49.5
ICD-10 Finland
Collapsed vertebra in diseases classified elsewhere
+∞
53.2
50
*
A49.9
ICD-10 Finland
Bacterial infection, unspecified
5.4
52.9
131
319
M54.5
ICD-10 Finland
Low back pain
4.6
52.5
180
571
YN7AD
NOMESCO Finland
CT examination of spine for dose design of radiotherapy
106.6
52.2
56
6
NA1BG
NOMESCO Finland
Cervical spine MRI examination with high intensity magnet
19.2
52.1
42
24
L03AA02
ATC
filgrastim; parenteral
9.8
50.3
62
72
329
Kela drug reimbursment
Lenalidomide
274.7
49.1
49
*
WZC00
NOMESCO Finland
Treatment plan or consultation
4.1
46.9
248
1057
A06AH03
ATC
naloxegol; oral
17.2
44.8
38
24
ZX112
NOMESCO Finland
Subcutaneous
10.7
44.7
51
53
N02AX02
ATC
tramadol; systemic, rectal
3.9
44.4
250
1102
JN4BD
NOMESCO Finland
Extensive body CT
4.8
43.5
123
330
ZX120
NOMESCO Finland
Intravenous
5.1
38.7
96
230
NA3CG
NOMESCO Finland
Lumbar spine extensive MRI examination with high intensity magnet
92.6
38.5
42
5
XW000
NOMESCO Finland
Bone marrow biopsy
6.6
35.8
62
106
R50.9
ICD-10 Finland
Fever, unspecified
4.1
34.7
116
349
M49.0*A18.0
ICD-10 Finland
Tuberculosis of spine
+∞
33.8
32
*
130
Kela drug reimbursment
Malignant tumour
4.2
33.3
106
307
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
4.7
32.5
87
220
M54.4
ICD-10 Finland
Lumbago with sciatica
5.2
32.4
75
168
YX9AD
NOMESCO Finland
Other CT eamination for dose design of radiotherapy
8.0
31.5
45
62
GD1AA
NOMESCO Finland
Thorax X-ray examination
3.3
31.2
286
1591
WW500
NOMESCO Finland
Blood transfusion
6.3
29.9
54
96
M49.4*G95.0
ICD-10 Finland
Neuropathic spondylopathy in syringomyelia and syringobulbia
+∞
29.5
28
*
A06AD11
ATC
lactulose; oral
3.6
28.4
119
413
NA7CG
NOMESCO Finland
Spine and spinal cord extensive MRI examination with high intensity magnet
68.8
28.3
32
5
NK6AN
NOMESCO Finland
Total body bone isotope imaging
6.6
27.3
46
76
L03AA13
ATC
pegfilgrastim; parenteral
6.1
27.0
50
91
J01EE01
ATC
sulfamethoxazole and trimethoprim; systemic
5.3
26.0
57
121
WD125
NOMESCO Finland
Demanding cystostatic therapy of methastized malignancy
5.1
25.8
59
130
A79
ICPC
Malignancy NOS
11.0
25.6
28
27
NJ3DA
NOMESCO Finland
Long bones of extremities X-ray examination
38.2
25.6
32
9
NAG53
NOMESCO Finland
Posterior or lateral fusion of thoracic spine with fixation, more than 3 vertebraea
+∞
25.2
24
*
ZX012
NOMESCO Finland
Radiotherapy with large shaped fields - isocentric therapy
4.5
25.1
67
168
A02BC02
ATC
pantoprazole; systemic
3.3
24.8
347
2316
TPH04
NOMESCO Finland
Cathetrisation of vein
3.0
24.0
139
580
NA2BG
NOMESCO Finland
Thoracal spine MRI examination with high intensity magnet
33.2
24.0
31
10
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
3.3
24.0
108
389
NA7EA
NOMESCO Finland
Scoliosis X-ray examination
91.9
23.9
26
*
YN7BD
NOMESCO Finland
Extensive CT examination of spine for dose design of radiotherapy
91.9
23.9
26
*
L04AX06
ATC
pomalidomide; oral
132.2
23.8
25
*
L28
ICPC
Limited function/disability (L)
3.2
23.7
120
463
N02BF01
ATC
gabapentin; oral
5.7
23.7
47
91
N02BF02
ATC
pregabalin; oral
6.7
23.6
39
63
AA1AA
NOMESCO Finland
Head X-ray examination
23.7
23.4
33
15
M47.2
ICD-10 Finland
Other spondylosis with radiculopathy
68.8
23.1
26
*
ABC36
NOMESCO Finland
Decompression of lumbar nerve roots
68.8
23.1
26
*
C78.0
ICD-10 Finland
Secondary malignant neoplasm of lung
8.6
22.9
30
37
G95.0
ICD-10 Finland
Syringomyelia and syringobulbia
126.6
22.8
24
*
393
Kela drug reimbursment
Pomalidomide
126.6
22.8
24
*
SPAT1229
SPAT
Assessment of need for aid
4.5
22.4
60
150
J18.9
ICD-10 Finland
Pneumonia, unspecified
2.7
22.4
174
846
1507
Kela drug reimbursment
Pomalidomide
230.9
21.8
22
*
NK6CT
NOMESCO Finland
Bone biopsy with CT guidance
45.8
21.6
26
6
L03
ICPC
Low back symptom/complaint
3.0
21.5
123
507
B01AB05
ATC
enoxaparin; parenteral
2.6
21.1
186
957
SPAT1230
SPAT
Aid fitting and borrowing and monitoring of use
3.2
20.9
101
377
A28
ICPC
Limited function/disability NOS
2.9
20.4
123
520
L01AA03
ATC
melphalan; systemic
60.5
20.1
23
*
NAR00
NOMESCO Finland
Complete excision of tumour of bone or cartilage of spine, unspecified
+∞
19.9
19
*
163
Kela drug reimbursment
Abiraterone and enzalutamide
19.3
19.4
29
16
C64.88
ICD-10 Finland
Other malignant neoplasm of kidney, except renal pelvis
6.7
19.1
31
49
YX9BD
NOMESCO Finland
Other extensive CT eamination for dose design of radiotherapy
22.0
18.8
27
13
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
3.4
18.8
77
259
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
3.1
18.8
90
333
M47.9
ICD-10 Finland
Spondylosis, unspecified
198.0
18.7
19
*
116
Kela drug reimbursment
Prostate cancer
3.8
18.6
63
187
M51.3
ICD-10 Finland
Other specified intervertebral disc degeneration
22.9
18.4
26
12
A04AA02
ATC
granisetron; systemic, transdermal
3.8
18.1
60
175
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
3.1
17.6
85
315
WD205
NOMESCO Finland
Therapy of methastized malignancy with hormones
17.9
17.6
27
16
FB1BD
NOMESCO Finland
Extensive CT examination of arteria pulmonalis
3.7
17.5
61
184
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
2.7
17.4
120
539
WD325
NOMESCO Finland
Demanding therapy of methastized malignancy with biomodifiers
13.3
17.4
30
24
WX2DD
NOMESCO Finland
Low-dose CT of skeleton in whole body
52.2
17.1
20
*
J01MA12
ATC
levofloxacin; systemic
2.6
17.0
122
559
NA2AD
NOMESCO Finland
Thoracic spine CT examination
66.0
16.9
19
*
TPH07
NOMESCO Finland
Cathetrisation of artery
3.1
16.9
82
305
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
3.9
16.8
54
154
M90.7*C90.0
ICD-10 Finland
Pathological fracture in multiple myeloma
+∞
16.8
16
*
YG1AD
NOMESCO Finland
CT examination of thorax for dose design of radiotherapy
7.0
16.8
26
39
M84.4
ICD-10 Finland
Pathological fracture, not elsewhere classified
93.7
16.7
18
*
L02BB04
ATC
enzalutamide; oral
18.8
16.7
25
14
WW300
NOMESCO Finland
Transfer of autologic stem cells
28.8
16.7
22
8
YL1AD
NOMESCO Finland
CT examination of pelvis for dose design of radiotherapy
6.4
16.6
28
46
SPAT1255
SPAT
Intravenous administration of medicine
4.0
16.6
51
141
WZC30
NOMESCO Finland
Teaching
2.8
16.6
101
425
S22.0
ICD-10 Finland
Fracture of thoracic vertebra
15.0
16.5
27
19
M54.6
ICD-10 Finland
Pain in thoracic spine
5.2
16.4
35
72
WD115
NOMESCO Finland
Multiple cystostatic therapy of methastized malignancy
6.5
16.1
27
44
NE1AA
NOMESCO Finland
Pelvis X-ray examination
3.7
15.9
53
155
M80.9
ICD-10 Finland
Unspecified osteoporosis with pathological fracture
13.6
15.9
27
21
S32.0
ICD-10 Finland
Fracture of lumbar vertebra
6.3
15.8
27
45
NA2CG
NOMESCO Finland
Thoracal spine extensive MRI examination with high intensity magnet
20.1
15.7
23
12
DM1QA
NOMESCO Finland
Paranasal sinuses X-ray examination in one projection
5.0
15.7
35
75
H02AB06
ATC
prednisolone; systemic
2.2
15.6
232
1455
WD515
NOMESCO Finland
Demanding therapy of malignancy with enzyme inhibitors and similar treatments
39.6
15.5
19
5
X76
ICPC
Malignant neoplasm breast female
7.0
15.5
24
36
C03CA01
ATC
furosemide; systemic
2.3
15.2
189
1097
KH1AE
NOMESCO Finland
Urinary tract ultrasound examination
3.9
15.2
48
135
NA7BG
NOMESCO Finland
Spine and spinal cord MRI examination with high intensity magnet
46.7
15.2
18
*
NA3DG
NOMESCO Finland
Lumbar spine very extensive MRI examination with high intensity magnet
33.0
14.9
19
6
N06AX21
ATC
duloxetine; oral
3.7
14.9
51
152
AA1AD
NOMESCO Finland
CT of head and brain
2.3
14.8
151
806
M03BC01
ATC
orphenadrine (citrate); systemic
2.7
14.8
90
377
ABC56
NOMESCO Finland
Decompression of lumbar spinal canal and nerve roots
154.9
14.5
15
*
NA1AD
NOMESCO Finland
Cervical spine CT examination
4.9
14.5
33
72
NA1CG
NOMESCO Finland
Cervical spine extensive MRI examination with high intensity magnet
17.7
14.4
22
13
1501
Kela drug reimbursment
Palbociclib
28.3
14.4
19
7
D48.0
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Bone and articular cartilage
15.1
14.2
23
16
197
Kela drug reimbursment
Sunitinib
44.0
14.2
17
*
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
3.0
14.0
68
252
NAG63
NOMESCO Finland
Posterior fusion of lumbar spine with fixation, more than 3 vertebraea
+∞
13.6
13
*
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
3.5
13.6
49
151
DM1AA
NOMESCO Finland
Paranasal sinuses X-ray examination without contrast
5.3
13.5
28
56
1XX32, ,
NOMESCO Finland
144.2
13.5
14
*
H05BA01
ATC
calcitonin (salmon synthetic); nasal, parenteral
5.8
13.5
25
45
M54.8
ICD-10 Finland
Other dorsalgia
9.8
13.2
26
28
L02BX03
ATC
abiraterone; oral
17.4
13.1
20
12
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
2.1
13.1
187
1133
394
Kela drug reimbursment
Palbociclib
29.4
13.0
17
6
R11
ICD-10 Finland
Nausea and vomiting
3.3
13.0
52
171
B03XA02
ATC
darbepoetin alfa; parenteral
6.0
12.9
23
40
ZX090
NOMESCO Finland
Other technic of radiotherapy
4.5
12.7
32
76
A18.0
ICD-10 Finland
Tuberculosis of bones and joints
+∞
12.6
12
*
M87.1
ICD-10 Finland
Osteonecrosis due to drugs
25.2
12.6
17
7
M54.2
ICD-10 Finland
Cervicalgia
4.4
12.5
32
77
SPAT1254
SPAT
Administration of medicine
2.6
12.4
85
376
M04AA01
ATC
allopurinol; systemic
2.5
12.3
92
424
EB1BI
NOMESCO Finland
Cone beam imaging of teeth and jaws (1–2 quarters)
11.5
12.2
22
20
WD225
NOMESCO Finland
Demanding therapy of methastized malignancy with hormones
11.5
12.2
22
20
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
2.0
12.1
227
1507
L02BA03
ATC
fulvestrant; parenteral
22.0
12.1
17
8
C61
ICD-10 Finland
Malignant neoplasm of prostate
2.6
12.0
80
348
J01MA02
ATC
ciprofloxacin; systemic
2.0
12.0
195
1229
L86
ICPC
Back syndrome with radiating pain
4.4
12.0
31
75
M03BX02
ATC
tizanidine; oral
2.0
11.8
239
1625
N02AJ06
ATC
codeine and paracetamol; systemic
2.1
11.8
176
1073
WX408
NOMESCO Finland
General anesthesy, balanced
2.2
11.8
131
714
NF3AA
NOMESCO Finland
Femur X-ray examination
5.7
11.8
22
40
ZZH31
NOMESCO Finland
Bone allograft, small pieces
31.0
11.7
15
5
J05AB01
ATC
aciclovir; systemic
2.3
11.5
109
557
B01AB10
ATC
tinzaparin; parenteral
2.8
11.4
63
249
N06AA09
ATC
amitriptyline; systemic
3.3
11.4
46
152
352
Kela drug reimbursment
Abiraterone and enzalutamide
15.6
11.4
18
12
5BA08, ,
NOMESCO Finland
20.7
11.2
16
8
XKC03
NOMESCO Finland
Water cystometry
5.0
11.1
24
50
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.1
10.9
138
789
M43.1
ICD-10 Finland
Spondylolisthesis
18.4
10.8
16
9
Y77
ICPC
Malignant neoplasm prostate
3.9
10.8
32
86
GA5AA
NOMESCO Finland
Rib X-ray examination
61.5
10.7
12
*
TPH20
NOMESCO Finland
Insertion of central venous catheter through subclavian or brachiocephalic vein
4.5
10.7
26
60
ZXD05
NOMESCO Finland
Urgent procedure
2.0
10.6
149
882
J09
ICD-10 Finland
Influenza due to identified zoonotic or pandemic influenza virus
5.2
10.6
22
44
N02BE01
ATC
paracetamol; systemic, rectal
2.8
10.6
396
3329
EBA10
NOMESCO Finland
Operative extraction of tooth
3.0
10.6
48
170
L02BB03
ATC
bicalutamide; oral
4.1
10.6
30
78
WX704
NOMESCO Finland
Intubation
3.2
10.5
43
143
L02BG04
ATC
letrozole; oral
3.2
10.5
43
143
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
2.3
10.5
98
495
Z01.8
ICD-10 Finland
Other specified special examinations
2.2
10.5
103
532
YNB10
NOMESCO Finland
Collection of stem cells for transplant
112.6
10.5
11
*
NAG62
NOMESCO Finland
Posterior fusion of lumbar spine with fixation, 2-3 vertebraea
+∞
10.5
10
*
115
Kela drug reimbursment
Breast cancer
2.8
10.4
54
206
L02AE02
ATC
leuprorelin; implant, parenteral
3.3
10.4
40
128
192
Kela drug reimbursment
Fulvestrant
19.3
10.3
15
8
3012
Kela drug reimbursment
Cabozantinib
24.0
10.3
14
6
M50.1
ICD-10 Finland
Cervical disc disorder with radiculopathy
24.0
10.3
14
6
1502
Kela drug reimbursment
Cabozantinib
24.0
10.3
14
6
A03FA02
ATC
cisapride; oral, rectal
3.2
10.2
43
146
C64
ICD-10 Finland
Malignant neoplasm of kidney, except renal pelvis
11.7
10.1
18
16
M05BA02
ATC
clodronic acid; systemic
15.0
10.1
16
11
M43.0
ICD-10 Finland
Spondylolysis
41.1
10.0
12
*
8140/3-C61.9
ICD-O-3
Adenocarcinoma, NOS, of prostate gland
2.4
10.0
73
331
Z94.8
ICD-10 Finland
Other transplanted organ and tissue status
20.6
9.9
14
7
A07AA02
ATC
nystatin; oral
3.4
9.8
36
112
NA3EA
NOMESCO Finland
Lumbar spine X-ray examination with flexion
56.3
9.7
11
*
L01XE04
ATC
[U] sunitinib
56.3
9.7
11
*
AA1BD
NOMESCO Finland
Extensive CT of head and brain
4.6
9.7
23
52
WD135
NOMESCO Finland
Demanding cystostatic therapy of methastized malignancy
15.5
9.6
15
10
M01AH05
ATC
etoricoxib; oral
1.9
9.6
240
1712
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
2.4
9.5
74
345
3054, ,
Kela drug reimbursment
18.0
9.5
14
8
1523, ,
Kela drug reimbursment
18.0
9.5
14
8
WW402
NOMESCO Finland
Leucoferesis
102.1
9.4
10
*
NAJ22
NOMESCO Finland
Posterior reduction of fractrue of thoracic spine
102.1
9.4
10
*
L01XE26
ATC
[U] cabozantinib
+∞
9.4
9
*
M46.4
ICD-10 Finland
Discitis, unspecified
+∞
9.4
9
*
398
Kela drug reimbursment
Ixazomib
+∞
9.4
9
*
ABC16
NOMESCO Finland
Microsurgical excision of lumbar intervertebral disc displacement
+∞
9.4
9
*
WW409
NOMESCO Finland
Other aferesis
22.3
9.4
13
6
ZXE20
NOMESCO Finland
More than three and less than five hours
2.3
9.2
75
357
R06AE07
ATC
cetirizine; oral
1.9
9.1
170
1098
ZX080
NOMESCO Finland
Image guided radiotherapy
4.4
9.0
23
55
UKC02
NOMESCO Finland
Cystoscopy
2.1
9.0
93
488
GD1BD
NOMESCO Finland
Thorax extensive CT-examination
3.1
9.0
39
135
N39.0
ICD-10 Finland
Urinary tract infection, site not specified
2.3
8.9
75
361
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
2.7
8.9
49
193
M05BA04
ATC
alendronic acid; oral
2.7
8.8
49
194
C78.7
ICD-10 Finland
Secondary malignant neoplasm of liver and intrahepatic bile duct
4.0
8.8
25
65
A04
ICPC
Weakness/tiredness general
2.3
8.8
71
336
N07BC02
ATC
methadone; systemic
51.0
8.7
10
*
B74
ICPC
Malignant neoplasm blood other
51.0
8.7
10
*
YL1BD
NOMESCO Finland
Extensive CT examination of pelvis for dose design of radiotherapy
4.5
8.7
21
48
JN4CD
NOMESCO Finland
Very extensive body CT
3.4
8.7
32
100
N17.9
ICD-10 Finland
Acute renal failure, unspecified
3.7
8.7
28
80
GD1AD
NOMESCO Finland
Thorax CT examination
3.1
8.6
37
127
JN3AD
NOMESCO Finland
Abdominal CT examination
2.4
8.5
62
281
R52.2
ICD-10 Finland
Other chronic pain
6.9
8.5
20
30
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
1.8
8.4
175
1163
C90.2
ICD-10 Finland
Extramedullary plasmacytoma
91.7
8.4
9
*
ZXM20
NOMESCO Finland
Intraoperative use of computerised tomography
91.7
8.4
9
*
NA2DG
NOMESCO Finland
Thoracal spine very extensive MRI examination with high intensity magnet
91.7
8.4
9
*
M48.5
ICD-10 Finland
Collapsed vertebra, not elsewhere classified
91.7
8.4
9
*
WD405
NOMESCO Finland
Simple antiboidy therapy of methastized malignancy
4.1
8.4
23
58
7227C
ICD-9 Finland
Intervertebral disk disorders, Intervertebral disk disorder with myelopathy[SYNDROMA ISCHIADICUM]
+∞
8.4
8
*
1505
Kela drug reimbursment
Ixazomib
+∞
8.4
8
*
NAG52
NOMESCO Finland
Posterior or lateral fusion of thoracic spine with fixation, 2-3 vertebraea
+∞
8.4
8
*
R52.1
ICD-10 Finland
Chronic intractable pain
+∞
8.4
8
*
EB1CI
NOMESCO Finland
Cone beam imaging of teeth and jaws (3-4 quarters)
11.0
8.3
15
14
166
Kela drug reimbursment
Dalteparin and tinzaparin (treatment for more than 6 months)
9.7
8.3
16
17
J15.9
ICD-10 Finland
Bacterial pneumonia, unspecified
2.5
8.3
53
225
JN3BD
NOMESCO Finland
Extensive abdominal CT
2.6
8.3
52
219
J05AB11
ATC
valaciclovir; oral
2.2
8.2
72
353
ZXM10
NOMESCO Finland
Intraoperative use of conventional X-ray imaging
3.3
8.1
31
99
R91
ICD-10 Finland
Abnormal findings on diagnostic imaging of lung
2.4
8.1
60
273
AA1CD
NOMESCO Finland
Very extensive CT of head and brain
6.5
8.1
20
32
L02BX02
ATC
degarelix; parenteral
9.2
8.1
16
18
L01XE33
ATC
[U] palbociclib
22.5
8.0
11
5
WF003
NOMESCO Finland
Adjuvant radiotherapy
3.6
7.9
26
75
SAA03
NOMESCO Finland
Extended examination of mouth
1.8
7.8
156
1020
J01MA14
ATC
moxifloxacin; systemic
2.6
7.8
48
200
G95.8
ICD-10 Finland
Other specified diseases of spinal cord
45.8
7.7
9
*
B01AB04
ATC
dalteparin; parenteral
3.3
7.7
29
92
L01EX07
ATC
cabozantinib; oral
18.7
7.6
11
6
N02AA01
ATC
morphine; systemic, rectal
6.4
7.6
19
31
L02BG06
ATC
exemestane; oral
6.4
7.6
19
31
ZX013
NOMESCO Finland
Radiotherapy with large shaped fields - SSD therapy
12.1
7.6
13
11
SPAT1148
SPAT
Treatment of chronic ulcer or burn
2.2
7.5
70
351
L29
ICPC
Musculoskeletal sympt/complt other
2.7
7.5
40
155
ABC53
NOMESCO Finland
Decompression of thoracic spinal canal and nerve roots
81.4
7.4
8
*
L02
ICPC
Back symptom/complaint
2.7
7.3
40
157
ABC60
NOMESCO Finland
Decompression of cervical spinal cord
+∞
7.3
7
*
NAG40
NOMESCO Finland
Anterior fusion of cervical spine without fixation
+∞
7.3
7
*
M47.1
ICD-10 Finland
Other spondylosis with myelopathy
+∞
7.3
7
*
M49
ICD-10 Finland
Spondylopathies in diseases classified elsewhere
+∞
7.3
7
*
NAG42
NOMESCO Finland
Posterior fusion of cervical spine with or without fixation
+∞
7.3
7
*
S22.1
ICD-10 Finland
Multiple fractures of thoracic spine
+∞
7.3
7
*
M49.0
ICD-10 Finland
Tuberculosis of spine
+∞
7.3
7
*
SPAT1263
SPAT
Sampling
1.7
7.3
180
1247
H02AB07
ATC
prednisone; oral
2.2
7.2
66
329
M80.8
ICD-10 Finland
Other osteoporosis with pathological fracture
30.5
7.2
9
*
L01EF01
ATC
palbociclib; oral
20.4
7.2
10
5
M54.1
ICD-10 Finland
Radiculopathy
8.1
7.2
15
19
379
Kela drug reimbursment
Apixaban, dabigatran, edoxaban and rivaroxaban for the long-term prevention of recurrent deep veinthrombosis and pulmonary embolism
4.2
7.1
19
47
X59
ICD-10 Finland
Exposure to unspecified factor
2.1
7.0
78
418
WW200
NOMESCO Finland
Immunization
4.5
7.0
17
39
M01AE01
ATC
ibuprofen; systemic, rectal
2.0
7.0
370
3170
A02BC05
ATC
esomeprazole; systemic
1.7
7.0
168
1152
NE1AD
NOMESCO Finland
Pelvis and hip bones CT examination
5.6
7.0
19
35
XKD03
NOMESCO Finland
Urethral pressure profilometry
6.0
7.0
18
31
PJD52
NOMESCO Finland
Block dissection of axillary lymph nodes
3.4
6.9
25
77
K44.9
ICD-10 Finland
Diaphragmatic hernia without obstruction or gangrene
2.6
6.9
41
168
M47.82
ICD-10 Finland
Other spondylosis, cervical region
8.5
6.9
14
17
R60.0
ICD-10 Finland
Localized oedema
2.2
6.9
59
286
WD415
NOMESCO Finland
Demanding antibody therapy of methastized malignancy
6.3
6.8
17
28
K08.3
ICD-10 Finland
Retained dental root
2.7
6.8
37
145
L02BA01
ATC
tamoxifen; oral
3.3
6.8
25
78
M45
ICD-10 Finland
Ankylosing spondylitis
40.7
6.8
8
*
322
Kela drug reimbursment
Sunitinib
40.7
6.8
8
*
M41.5
ICD-10 Finland
Other secondary scoliosis
40.7
6.8
8
*
N05CF01
ATC
zopiclone; oral
1.8
6.8
147
978
JN3AA
NOMESCO Finland
Abdominal X-ray examination without contrast
3.2
6.7
26
84
M03BC51
ATC
orphenadrine, combinations; systemic
1.9
6.7
98
579
NB1AA
NOMESCO Finland
Shoulder X-ray examination without contrast
2.8
6.6
34
129
SPAT1256
SPAT
Intramuscular and subcutaneous injection
1.7
6.6
189
1353
G04BD04
ATC
oxybutynin; oral, transdermal
2.7
6.5
35
136
SPAT1137
SPAT
Taking care of patient’s/customer’s hygiene
2.6
6.5
37
148
XKD06
NOMESCO Finland
Physiologic investigation of micturition
3.6
6.5
21
60
KA1AE
NOMESCO Finland
Kidney ultrasound examination
4.0
6.5
18
46
M48.9
ICD-10 Finland
Spondylopathy, unspecified
70.8
6.4
7
*
WX725
NOMESCO Finland
Noninvasive ventilation
3.0
6.4
28
97
M79.0
ICD-10 Finland
Rheumatism, unspecified
6.1
6.4
16
27
WX892
NOMESCO Finland
Monitored bed care
2.5
6.3
40
169
AB5BT
NOMESCO Finland
Blockage of nerv root with X-ray guidance
+∞
6.3
6
*
9211
FHL
Exploration or removal of diskusprolapse
+∞
6.3
6
*
M49.1*A23.9
ICD-10 Finland
Brucella spondylitis
+∞
6.3
6
*
NAG41
NOMESCO Finland
Anterior fusion of cervical spine with fixation
+∞
6.3
6
*
ABC63
NOMESCO Finland
Decompression of thoracic spinal cord
+∞
6.3
6
*
M46.9
ICD-10 Finland
Inflammatory spondylopathy, unspecified
+∞
6.3
6
*
NA1DG
NOMESCO Finland
Cervical spine very extensive MRI examination with high intensity magnet
+∞
6.3
6
*
M01AH01
ATC
celecoxib; oral
2.0
6.3
73
398
G55.1*M51.1
ICD-10 Finland
Compression of nerve roots and nerve plexus in disc diseases in the lumbar region and other regions
27.1
6.2
8
*
EBA15
NOMESCO Finland
Extraction of multiple teeth
3.4
6.2
22
67
NH1AA
NOMESCO Finland
Ankle X-ray examination without contrast
2.7
6.2
32
122
J94.8
ICD-10 Finland
Other specified pleural conditions
5.9
6.2
16
28
8310/3-C64.9
ICD-O-3
Clear cell adenocarcinoma, NOS, of kidney, NOS
5.9
6.2
16
28
A06AC51
ATC
ispaghula, combinations; oral
3.1
6.2
25
83
M01AB05
ATC
diclofenac; systemic, rectal
1.7
6.2
258
2028
G82.2
ICD-10 Finland
Paraplegia, unspecified
12.8
6.1
10
8
D41.0
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Kidney
3.7
6.1
19
53
R4110
NOMESCO Finland
Physiotherapy
1.8
6.1
120
773
YA1AD
NOMESCO Finland
CT examination of head and neck for dose design of radiotherapy
8.8
6.1
12
14
SPAT1203
SPAT
Injection therapy, other than intramuscular or subcutaneous
3.4
6.1
22
68
E87.6
ICD-10 Finland
Hypokalaemia
3.4
6.1
22
68
UJF32
NOMESCO Finland
Coloscopy
1.8
6.1
114
724
EB1AI
NOMESCO Finland
Cone beam imaging of teeth and jaws (one quarter)
6.8
6.1
14
21
KAC10
NOMESCO Finland
Total nephrectomy with capsule
10.2
6.1
11
11
NE1BG
NOMESCO Finland
Pelvic, hip and femur MRI examination with high intensity magnet
6.2
6.0
15
25
R52.0
ICD-10 Finland
Acute pain
4.0
6.0
17
44
M01AX17
ATC
nimesulide; oral
1.8
6.0
104
645
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
100
112
11.24
84.79
20.9
2.9
52.19
126.98
mg/l
0.68
85
89
99
111
11.20
83.84
20.2
2.8
2.75
1.13
ratio
—
8
9
99
112
11.10
83.28
21.1
2.9
29.67
58.12
mg/l
0.53
84
91
168
423
5.79
66.83
9.3
4.5
243.88
248.31
u/l
0.17
163
405
138
305
6.12
63.00
16.5
2.2
64.66
66.47
g/l
1.81
130
280
174
569
4.39
48.11
6.3
3.2
0.79
0.81
mmol/l
1.84
164
533
332
1798
4.38
42.89
24.4
6.5
1.21
1.21
mmol/l
0.37
284
1505
73
124
6.85
42.66
17.7
1.8
3.97
0.98
g/l
2.22
62
106
167
579
4.02
41.73
3.0
1.8
—
—
—
0
0
75
136
6.43
41.06
17.9
1.5
—
—
—
0
0
308
1639
3.89
39.50
19.2
5.8
1.21
1.21
mmol/l
0.47
293
1474
101
252
4.90
38.77
8.6
2.8
11.28
10.51
g/l
0.31
95
227
48
65
8.16
34.18
2.0
1.6
—
—
—
0
0
48
65
8.16
34.18
2.0
1.6
—
—
—
0
0
66
126
5.98
34.08
19.8
1.5
7.96
10.88
g/l
3.08
61
109
35
32
11.79
33.28
5.7
2.5
—
—
—
0
0
139
488
3.69
33.13
8.2
5.4
1.02
1.05
mmol/l
0.36
126
444
46
64
7.90
31.97
7.5
5.0
321.80
275.29
iu/ml
—
5
7
55
95
6.47
31.35
2.1
1.7
—
—
—
0
0
52
92
6.27
28.89
2.2
1.7
—
—
—
0
0
321
1960
3.32
28.87
31.8
9.2
3.66
4.19
e9/l
4.46
303
1708
116
398
3.59
28.18
2.7
1.8
—
—
—
0
0
115
399
3.54
27.39
2.7
1.7
—
—
—
0
0
275
1568
2.99
27.37
11.9
4.5
32.60
34.82
g/l
7.91
260
1451
279
1620
2.95
26.54
12.3
5.6
25.03
26.66
%
1.30
270
1518
232
1223
2.88
26.48
9.0
3.4
2.32
2.35
mmol/l
2.15
211
1071
276
1600
2.92
26.22
11.4
5.4
58.88
58.05
%
0.46
269
1508
31
34
9.73
25.91
2.6
2.8
—
—
—
0
0
115
413
3.41
25.81
7.6
7.8
1.27
1.38
mmol/l
0.09
85
339
51
99
5.69
25.69
1.8
1.2
—
—
—
0
0
112
403
3.38
24.99
7.8
7.9
5.17
5.13
kpa
0.17
101
393
112
403
3.38
24.99
7.8
7.8
12.45
12.09
kpa
0.28
101
393
272
1590
2.84
24.99
12.0
5.4
2.46
2.90
%
2.42
264
1490
84
251
3.90
24.82
2.3
1.4
—
—
—
0
0
266
1583
2.70
22.83
4.6
2.5
—
—
—
0
0
288
1802
2.71
22.02
12.4
16.4
1.32
1.33
inr
0.06
63
545
50
113
4.86
21.15
20.3
1.5
0.03
0.00
g/l
0.49
45
100
315
2095
2.74
20.72
12.1
4.7
6.87
6.81
mmol/l
0.20
298
1964
39
72
5.84
20.63
2.2
1.8
—
—
—
0
0
197
1054
2.57
20.44
4.0
2.3
46.78
66.90
u/l
3.16
188
975
31
46
7.17
20.22
2.0
1.7
—
—
—
0
0
112
452
2.98
20.19
4.3
2.7
1.77
1.77
%
0.01
104
410
32
50
6.82
19.92
1.5
1.6
—
—
—
0
0
29
41
7.50
19.73
1.7
1.5
—
—
—
0
0
29
41
7.50
19.73
1.7
1.5
—
—
—
0
0
30
45
7.08
19.37
2.0
1.7
—
—
—
0
0
65
193
3.78
19.18
1.7
1.3
—
—
—
0
0
331
2304
2.73
19.02
7.7
4.1
41.80
2204.06
e6/l
—
5
54
28
40
7.40
18.87
1.4
1.6
99.22
110.75
u/ml
—
9
8
91
339
3.12
18.77
8.3
6.5
10.21
10.32
mmol/l
0.05
84
320
161
825
2.49
17.82
4.3
2.4
—
—
—
0
0
27
42
6.78
16.84
2.3
1.6
—
—
—
0
0
27
42
6.78
16.84
2.3
1.6
—
—
—
0
0
27
42
6.78
16.84
2.3
1.6
—
—
—
0
0
68
228
3.34
16.60
5.5
6.8
25.53
24.87
mmol/l
0.65
59
221
185
1059
2.28
15.48
6.6
3.1
59.03
32.32
u/l
1.23
178
1005
216
1323
2.23
15.27
5.1
3.1
—
—
—
0
0
162
882
2.32
15.22
8.5
2.7
14396.09
6569.21
umol/l
0.36
150
765
121
592
2.44
14.38
3.4
1.9
28.56
29.62
s
1.56
116
576
54
171
3.46
14.37
1.8
2.0
1.09
2.82
ug/l
0.51
46
153
355
2710
2.56
14.30
25.5
7.4
91.41
80.91
u/l
2.26
346
2524
19
8
24.73
13.90
1.2
1.9
—
—
—
0
0
177
1035
2.18
13.68
2.6
2.0
133.57
312.35
u/l
1.51
157
963
105
492
2.49
13.64
3.2
2.4
20.06
21.94
%
0.85
92
429
30
64
4.96
13.50
1.7
1.3
—
—
—
0
0
30
64
4.96
13.50
1.7
1.3
—
—
—
0
0
144
781
2.25
13.36
3.6
2.5
5.01
6.04
e6/l
0.34
135
703
64
235
3.01
13.33
3.9
4.0
1.87
2.39
mmol/l
0.48
51
182
219
1401
2.11
13.31
5.1
3.6
40.77
69.51
ng/l
0.53
176
1073
192
1180
2.11
12.86
3.6
3.1
1183.71
1684.59
ng/l
1.68
169
1022
185
1141
2.07
12.10
5.3
3.1
29.07
136.21
e6/l
1.16
164
883
95
455
2.38
11.62
4.3
4.4
19.26
36.91
ug/l
0.41
75
369
77
336
2.56
11.50
7.0
3.5
2.21
1.83
mmol/l
0.32
67
271
28
65
4.53
11.40
1.7
1.6
—
—
—
0
0
168
1021
2.04
11.26
5.0
3.0
0.29
0.57
e6/l
1.51
151
772
83
384
2.43
10.92
6.9
2.5
8.13
8.59
umol/l
0.10
77
341
24
54
4.64
10.14
1.4
1.2
—
—
—
0
0
122
685
2.08
9.96
6.1
3.1
2.47
2.46
mmol/l
0.57
109
610
57
232
2.67
9.74
2.3
1.5
—
—
—
0
0
21
27
8.11
9.73
1.8
3.2
31.70
40.23
%
—
10
13
43
151
3.05
9.63
3.9
4.4
24.97
25.14
mmol/l
0.11
37
145
42
148
3.03
9.35
3.9
1.8
—
—
—
0
0
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
37
123
3.19
9.08
2.9
2.3
0.35
0.40
u/ml
0.33
27
71
27
73
3.87
9.03
1.9
1.4
—
—
—
0
0
23
55
4.36
9.02
1.9
1.7
—
—
—
0
0
39
135
3.07
8.95
3.1
2.8
—
—
—
0
0
19
24
8.22
8.94
2.5
1.7
—
—
—
0
0
19
24
8.22
8.94
2.5
1.7
—
—
—
0
0
24
61
4.10
8.71
1.7
1.7
—
—
—
0
0
24
61
4.10
8.71
1.5
1.4
—
—
—
0
0
146
916
1.89
8.46
2.3
2.0
3.62
3.13
mg/l
0.94
129
774
228
1643
1.80
8.39
5.9
3.5
0.04
0.00
estimate
0.49
46
321
17
20
8.79
8.38
2.7
1.7
—
—
—
0
0
17
20
8.79
8.38
2.9
1.7
—
—
—
0
0
17
20
8.79
8.38
2.7
1.7
—
—
—
0
0
114
663
1.97
8.27
2.4
1.6
1.27
1.45
mg/l
0.35
92
532
38
137
2.94
8.13
2.8
1.6
—
—
—
0
0
19
43
4.57
7.97
1.9
1.8
—
—
—
0
0
198
1396
1.76
7.63
3.3
2.6
249.28
149.53
ug/l
2.20
188
1264
11
6
18.75
7.63
1.0
1.0
—
—
—
0
0
38
143
2.81
7.53
5.0
4.8
1.84
1.53
%
1.36
31
138
21
54
4.03
7.52
1.8
1.7
—
—
—
0
0
225
1650
1.74
7.51
6.0
3.5
0.00
0.00
estimate
-0.00
41
290
37
139
2.81
7.36
1.7
3.4
244.38
65.07
u/ml
0.69
37
132
223
1639
1.73
7.32
7.8
4.8
0.00
0.00
estimate
-0.00
43
307
18
42
4.42
7.28
1.3
1.4
9685.09
26831.00
e6/l
0.71
11
22
101
599
1.89
6.79
4.4
2.8
1.19
1.27
e6/l
0.10
69
338
27
89
3.17
6.74
1.6
1.4
234.31
285.03
ug/g
0.52
18
59
20
54
3.83
6.71
3.8
2.2
33.80
32.65
pg
0.69
20
54
19
51
3.85
6.43
1.3
1.2
280.60
371.35
u/ml
—
10
23
97
578
1.87
6.40
5.1
2.9
3.51
2.21
e6/l
0.53
65
320
10
8
12.75
6.11
12.8
3.8
—
—
—
0
0
60
309
2.09
5.99
2.7
2.9
153.88
220.17
ng/l
1.16
52
282
15
26
5.93
5.88
1.0
1.2
—
—
—
0
0
41
183
2.37
5.78
7.5
3.3
25.67
25.22
mmol/l
0.33
41
176
19
56
3.50
5.65
1.6
1.7
—
—
—
0
0
28
105
2.78
5.61
1.5
1.8
—
—
—
0
0
185
1362
1.62
5.58
2.6
2.1
74.64
78.46
nmol/l
0.88
168
1179
109
700
1.74
5.54
5.2
3.3
56.48
356.87
ng/l
3.54
93
570
301
2503
1.63
5.37
6.7
3.8
21.47
14.02
mm/h
6.72
281
2249
37
166
2.34
5.17
8.7
4.0
51.24
48.20
%
0.30
37
160
13
25
5.32
4.80
1.2
1.4
—
—
—
0
0
45
227
2.09
4.75
6.7
2.9
120.18
126.18
g/l
0.95
45
219
13
26
5.12
4.66
2.6
2.2
391.62
516.38
e6/l
0.61
13
26
21
75
2.89
4.61
1.5
1.3
—
—
—
0
0
169
1264
1.54
4.54
6.9
3.7
—
—
—
0
0
51
275
1.97
4.50
3.2
3.8
118.11
86.80
ng/l
0.97
45
239
11
19
5.91
4.47
1.4
1.3
23.09
28.36
u/l
0.19
11
14
13
28
4.75
4.40
1.5
1.0
—
—
—
0
0
127
897
1.58
4.36
7.0
3.6
0.00
0.01
estimate
0.50
40
284
12
24
5.11
4.34
3.1
1.4
—
—
—
0
0
12
24
5.11
4.34
3.1
1.4
—
—
—
0
0
42
214
2.06
4.33
3.7
2.5
0.43
0.30
e6/l
0.23
42
207
8
9
9.03
4.29
2.0
1.4
—
—
—
0
0
13
29
4.59
4.28
1.4
1.1
—
—
—
0
0
104
709
1.61
4.12
2.0
1.8
1121.96
1166.80
nmol/l
0.17
87
536
10
18
5.66
3.99
3.1
1.5
—
—
—
0
0
34
167
2.12
3.87
2.9
4.1
216.36
1767.64
u/ml
0.81
25
142
15
50
3.07
3.72
5.7
3.0
4.05
4.42
e9/l
0.30
15
50
10
20
5.09
3.71
3.4
1.5
—
—
—
0
0
10
20
5.09
3.71
3.4
1.5
—
—
—
0
0
375
3405
1.66
3.64
47.3
14.2
29.68
27.87
mg/l
0.49
357
2692
10
21
4.85
3.57
2.2
4.2
—
—
—
0
0
61
933
0.60
3.45
1.8
1.6
1.77
1.33
mmol/l
0.83
53
749
14
47
3.04
3.44
2.1
1.4
—
—
—
0
0
14
47
3.04
3.44
2.0
1.4
—
—
—
0
0
14
47
3.04
3.44
2.0
1.4
—
—
—
0
0
14
47
3.04
3.44
2.1
1.4
—
—
—
0
0
311
3442
0.68
3.36
4.3
4.5
4.50
4.53
mmol/l
0.17
282
3122
100
707
1.54
3.34
7.3
3.8
1.02
1.02
kg/l
0.24
14
109
14
48
2.98
3.33
2.0
1.4
—
—
—
0
0
9
19
4.81
3.25
1.1
2.2
—
—
—
0
0
13
39
3.40
3.25
1.8
3.5
2.82
4.13
nmol/l
0.61
13
39
12
34
3.60
3.22
1.6
1.4
—
—
—
0
0
14
49
2.92
3.22
1.3
1.0
—
—
—
0
0
309
3416
0.68
3.21
4.3
4.5
1.38
1.46
mmol/l
2.29
280
3068
208
1706
1.41
3.20
3.3
2.4
—
—
—
0
0
15
55
2.79
3.18
7.3
3.3
57.00
58.07
%
0.13
15
55
249
2111
1.41
3.15
3.9
3.0
62.30
54.58
u/l
0.61
230
1933
14
50
2.86
3.11
1.1
1.2
—
—
—
0
0
322
3525
0.68
3.06
4.6
5.1
2.61
2.65
mmol/l
0.34
288
3168
7
12
5.91
3.03
1.4
1.4
—
—
—
0
0
13
46
2.88
2.94
2.2
1.4
—
—
—
0
0
8
17
4.77
2.93
1.1
1.1
—
—
—
0
0
7
205
0.33
2.87
1.4
1.9
—
—
—
0
0
299
3299
0.71
2.75
4.1
4.0
1.37
1.25
mmol/l
2.46
270
2939
7
14
5.06
2.74
1.0
1.1
—
—
—
0
0
49
308
1.66
2.67
3.7
2.2
27.00
44.14
u/l
0.63
44
268
16
67
2.44
2.66
1.7
1.5
—
—
—
0
0
18
80
2.30
2.64
3.2
2.8
16.40
15.98
%
0.17
11
43
19
87
2.24
2.61
1.2
1.4
—
—
—
0
0
119
917
1.41
2.51
1.9
1.5
18.04
20.74
nmol/l
1.21
107
761
7
16
4.43
2.48
2.1
3.4
—
—
—
0
0
18
83
2.22
2.44
1.3
1.2
—
—
—
0
0
301
3294
0.73
2.38
5.9
6.1
41.45
40.47
mmol/mol
0.98
278
2984
85
624
1.45
2.34
1.2
1.2
1.10
1.34
u/ml
0.20
23
146
51
337
1.58
2.30
3.1
2.2
6.33
7.52
ug/l
0.19
41
293
(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection
7
18
3.93
2.26
1.1
1.2
—
—
—
0
0
5
9
5.60
2.22
1.0
1.1
—
—
—
0
0
17
82
2.12
2.09
1.3
1.2
—
—
—
0
0
10
39
2.60
1.95
1.8
1.7
—
—
—
0
0
9
34
2.68
1.87
1.0
1.4
—
—
—
0
0
61
439
1.45
1.87
14.8
6.5
—
—
—
0
0
6
18
3.36
1.75
1.8
2.7
229.00
211.56
u/l
—
6
18
5
13
3.88
1.72
1.2
1.0
—
—
—
0
0
56
404
1.44
1.71
5.9
3.2
—
—
—
0
0
10
40
2.53
1.67
2.2
1.2
—
—
—
0
0
16
83
1.96
1.66
1.5
1.5
—
—
—
0
0
17
91
1.90
1.63
1.2
1.3
—
—
—
0
0
5
14
3.60
1.62
1.4
1.4
—
—
—
0
0
28
177
1.62
1.56
1.1
1.2
19.93
163.07
iu/ml
—
8
68
6
21
2.88
1.51
1.0
1.3
—
—
—
0
0
6
21
2.88
1.51
1.0
1.6
—
—
—
0
0
9
38
2.40
1.46
2.0
1.8
—
—
—
0
0
7
28
2.52
1.45
2.0
1.7
—
—
—
0
0
5
16
3.15
1.44
2.4
1.6
—
—
—
0
0
9
42
2.17
1.34
1.3
1.7
—
—
—
0
0
173
1516
1.23
1.33
2.3
2.0
85.18
94.65
pmol/l
1.82
118
774
27
177
1.56
1.32
1.1
1.3
—
53.80
—
0
10
50
373
1.38
1.30
1.3
1.4
—
—
—
0
0
8
35
2.31
1.27
2.5
3.5
—
—
—
0
0
6
25
2.42
1.24
1.5
1.7
—
—
—
0
0
328
3451
0.81
1.14
5.0
4.8
6.11
6.04
mmol/l
0.39
293
3063
36
260
1.42
1.14
5.8
2.8
64.24
57.67
ml/min/173m2
0.59
21
102
7
30
2.35
1.13
2.4
2.0
—
—
—
0
0
271
2517
1.20
1.07
5.4
3.7
14.87
15.02
pmol/l
0.45
252
2224
14
82
1.73
1.06
1.4
2.4
—
—
—
0
0
14
82
1.73
1.06
1.6
1.3
—
—
—
0
0
19
122
1.58
1.04
1.1
1.1
—
—
—
0
0
9
46
1.98
1.04
1.0
1.0
1.56
1.52
g/l
—
9
40
5
22
2.29
1.03
2.2
2.0
—
—
—
0
0
19
124
1.56
0.98
1.3
1.3
—
—
—
0
0
5
23
2.19
0.98
2.2
1.9
—
—
—
0
0
11
62
1.79
0.95
1.4
1.4
—
230.16
—
0
27
16
102
1.59
0.91
2.4
1.4
—
—
—
0
0
15
95
1.60
0.88
6.9
3.3
1.55
1.67
mg/l
0.27
15
88
12
72
1.69
0.86
1.3
1.4
100.43
71.51
e6/l
—
7
55
12
72
1.69
0.86
1.3
1.3
27.50
60.85
e6/l
—
6
53
93
811
1.19
0.73
2.1
1.9
434.99
15174922.08
pmol/l
0.78
80
659
5
26
1.93
0.71
1.0
1.1
285.00
266.55
mg/l
—
5
20
7
42
1.68
0.68
1.0
1.1
—
—
—
0
0
377
3661
1.20
0.67
47.2
17.1
138.88
139.67
mmol/l
6.76
371
3537
11
70
1.59
0.65
1.0
1.1
—
—
—
0
0
15
105
1.44
0.61
2.3
2.3
26.60
69.77
ug/min
—
10
57
377
3671
1.18
0.59
49.4
17.2
4.00
3.99
mmol/l
0.12
370
3542
5
89
0.56
0.56
1.0
1.4
—
—
—
0
0
10
65
1.55
0.56
1.3
1.3
—
—
—
0
0
161
1494
1.12
0.54
8.5
5.2
23.71
2.83
ug/l
0.86
145
1315
13
93
1.41
0.48
1.4
1.6
—
—
—
0
0
78
870
0.87
0.48
3.7
3.1
0.84
0.83
ug/l
0.05
60
628
37
438
0.83
0.47
1.2
1.2
1.42
9.88
u/ml
—
10
151
0
17
0.00
0.40
0.0
1.3
—
—
—
0
0
5
35
1.43
0.39
1.0
1.0
—
—
—
0
0
5
36
1.39
0.38
1.0
1.1
—
3.91
—
0
14
323
3145
1.10
0.37
6.0
4.4
10.70
2.02
mu/l
0.50
292
2778
128
1204
1.09
0.32
6.9
4.4
19.95
21.73
%
0.80
74
629
5
38
1.32
0.23
1.0
1.1
—
—
—
0
0
0
11
0.00
0.21
0.0
1.5
—
—
—
0
0
0
11
0.00
0.21
0.0
1.2
—
—
—
0
0
(3011547) Coagulation factor VII activity actual/normal in Platelet poor plasma by Coagulation assay
0
10
0.00
0.21
0.0
1.1
—
112.60
—
0
10
0
12
0.00
0.21
0.0
1.8
—
—
—
0
0
51
471
1.09
0.21
1.2
1.2
10.11
36.59
iu/ml
—
10
147
47
507
0.92
0.19
4.6
4.7
32.91
31.98
%
0.37
35
330
8
72
1.11
0.16
2.8
1.6
31.13
43.77
nmol/l
—
8
66
9
80
1.13
0.15
1.0
1.1
—
18.62
—
0
10
379
3818
0.95
0.11
64.1
21.3
4.12
4.45
e12/l
22.86
374
3657
379
3817
0.95
0.11
64.1
21.3
232.99
242.06
e9/l
1.52
374
3677
379
3815
0.95
0.10
64.4
21.5
37.15
39.82
%
11.74
342
3541
7
65
1.08
0.08
1.6
1.2
—
—
—
0
0
371
3688
1.04
0.08
30.7
10.3
25.31
24.65
u/l
0.34
364
3519
332
3341
0.97
0.06
40.0
14.2
77.08
75.75
ml/min/173m2
0.51
294
2724
120
1209
0.99
0.01
3.9
3.8
14.62
8.89
mg/mmol
0.61
82
757
118
1172
1.01
0.01
3.2
3.2
7.17
7.49
mmol/l
0.35
97
953
30
294
1.02
0.00
1.8
1.8
1.65
1.57
%
0.28
23
252
15
145
1.04
0.00
1.3
1.7
—
—
—
0
0
13
133
0.98
0.00
1.1
1.6
—
—
—
0
0
37
367
1.01
0.00
1.4
1.5
—
—
—
0
0
5
57
0.88
-0.00
1.2
1.5
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
21.08
—
0
5
0
5
0.00
-0.00
0.0
1.0
—
100.00
—
0
5
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
116.80
—
0
5
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
3.5
—
106.12
—
0
6
0
6
0.00
-0.00
0.0
1.0
—
8.57
—
0
6
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.0
—
—
—
0
0
5
54
0.93
-0.00
3.4
1.7
142.60
202.27
pmol/l
—
5
48
5
55
0.91
-0.00
1.0
1.2
—
64.70
—
0
10
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
4.2
—
0.60
—
0
5
0
5
0.00
-0.00
0.0
3.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
125.43
—
0
7
0
5
0.00
-0.00
0.0
3.0
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint M13_SPONDYLOPATHINOTH and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_SPONDYLOPATHINOTH | 5.167 [4.07, 6.56] | < 0.001 |
| Birth year | 0.999 [0.99, 1.01] | 0.863 |
During the follow-up period (1.1.1998 — 31.12.2019), 652 out of 1121 females with M13_SPONDYLOPATHINOTH died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_SPONDYLOPATHINOTH | 5.293 [4.03, 6.95] | < 0.001 |
| Birth year | 0.985 [0.98, 1.0] | 0.003 |
During the follow-up period (1.1.1998 — 31.12.2019), 776 out of 1200 males with M13_SPONDYLOPATHINOTH died.
Mortality risk
Mortality risk for people of age
years, who have M13_SPONDYLOPATHINOTH.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.484% | 0.855% |
| 5 | 3.033% | 5.448% |
| 10 | 7.674% | 13.902% |
| 15 | 14.248% | 24.854% |
| 20 | 24.02% | 38.395% |
Relationships between endpoints
↥Index endpoint: M13_SPONDYLOPATHINOTH – Spondylopathies in diseases classified elsewhere
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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