No definition available.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519972 |
1. Apply sex-specific ruleNone |
519972 |
2. Check conditionsNone |
519972 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
379 |
4. Check minimum number of eventsNone |
379 |
5. Include endpointsNone |
379 |
6. Filter based on genotype QC (FinnGen only) |
371 |
Control definitions (FinnGen only)
- Control exclude
- M13_SOFTTISSUE
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- M67
- Name in latin
- Hypertrophia membranae synovialis non alibi classificata
Similar endpoints
↥List of similar endpoints to
Synovial hypertrophy, not elsewhere classified
based on the number of shared cases.
Similar with more cases:
- Disorders of synovium and tendon
- Soft tissue disorders
- Diseases of the musculoskeletal system and connective tissue
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 3056 | 1552 | 1498 |
| Only index persons | 3008 | 1538 | 1470 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.04 | 0.04 | 0.04 |
| Only index persons | 0.06 | 0.06 | 0.06 |
| Median age at first event (years) | |||
| Whole population | 36.05 | 35.31 | 36.81 |
| Only index persons | 36.00 | 35.29 | 36.74 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 371 | 219 | 152 |
| Unadjusted period prevalence (%) | 0.07 | 0.08 | 0.07 |
| Median age at first event (years) | 38.41 | 36.52 | 41.12 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 379
- Matched controls
- 3790
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
NGF00
NOMESCO Finland
Excision of plica of synovy of knee
181.9
322.5
159
15
M67.2
ICD-10 Finland
Synovial hypertrophy, not elsewhere classified
+∞
307.7
379
*
NGF25
NOMESCO Finland
Operation for osteochondritis of knee, arthroscopic
15.6
102.1
99
84
NGF15
NOMESCO Finland
Total synovectomy of knee, arthroscopic
56.1
85.4
49
10
M22.4
ICD-10 Finland
Chondromalacia patellae
18.7
70.8
59
37
M23.2
ICD-10 Finland
Derangement of meniscus due to old tear or injury
8.0
67.2
110
184
NGD05
NOMESCO Finland
Partial excision of meniscus of knee, arthroscopic
7.5
56.4
95
162
NGA30
NOMESCO Finland
Exploration of knee joint, arthroscopic
10.7
55.0
65
72
M17.1
ICD-10 Finland
Other primary gonarthrosis
4.9
38.9
107
282
M25.5
ICD-10 Finland
Pain in joint
4.0
37.7
170
645
M79.6
ICD-10 Finland
Pain in limb
3.5
31.0
174
743
M75.1
ICD-10 Finland
Rotator cuff syndrome
4.2
29.4
95
279
M23.8
ICD-10 Finland
Other internal derangements of knee
8.1
27.7
39
53
S83.2
ICD-10 Finland
Tear of meniscus, current
5.7
27.3
55
109
S83.6
ICD-10 Finland
Sprain and strain of other and unspecified parts of knee
6.2
25.9
47
84
M01AX05
ATC
glucosamine; oral
4.1
24.3
78
226
M01AH05
ATC
etoricoxib; oral
3.2
23.6
272
1677
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
2.9
23.2
197
1026
N03AX12
ATC
[U] gabapentin; oral
4.0
23.1
76
224
NBG15
NOMESCO Finland
Acromioplastia, arthroscopic
25.8
22.5
31
13
M67.4
ICD-10 Finland
Ganglion
7.4
22.5
34
50
N02AX02
ATC
tramadol; systemic, rectal
2.9
22.1
170
835
NGF35
NOMESCO Finland
Plastic operation of joint cartilage of knee
9.6
21.4
26
29
M23.9
ICD-10 Finland
Internal derangement of knee, unspecified
4.4
21.3
60
157
N02AJ06
ATC
codeine and paracetamol; systemic
2.7
20.2
184
975
M01AH01
ATC
celecoxib; oral
3.6
20.1
75
240
M19.0
ICD-10 Finland
Primary arthrosis of other joints
5.0
20.0
46
102
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
4.8
18.6
45
104
M01AX17
ATC
nimesulide; oral
3.2
18.6
92
350
G56.0
ICD-10 Finland
Carpal tunnel syndrome
3.8
18.1
62
186
M13.9
ICD-10 Finland
Arthritis, unspecified
5.1
17.7
39
83
M75.4
ICD-10 Finland
Impingement syndrome of shoulder
15.8
17.4
28
19
M01AC06
ATC
meloxicam; systemic, rectal
2.6
16.0
136
682
N03AX16
ATC
[U] pregabalin
2.9
15.6
90
370
M01AB05
ATC
diclofenac; systemic, rectal
2.5
15.3
268
1847
M01AE02
ATC
naproxen; oral, rectal
2.4
14.9
236
1547
M54.5
ICD-10 Finland
Low back pain
2.4
14.8
146
779
H02AB06
ATC
prednisolone; systemic
2.3
14.6
178
1039
M67.8
ICD-10 Finland
Other specified disorders of synovium and tendon
44.3
14.2
17
*
S18
ICPC
Laceration/cut
2.3
14.1
171
993
NG1AA
NOMESCO Finland
Knee X-ray examination without contrast
3.6
13.2
47
144
WX320
NOMESCO Finland
Spinalanesthesy
2.5
13.1
98
457
L08
ICPC
Shoulder symptom/complaint
2.8
13.1
76
312
ACC51
NOMESCO Finland
Release of median nerve
4.4
13.1
34
83
M77.1
ICD-10 Finland
Lateral epicondylitis
4.1
13.0
37
97
L15
ICPC
Knee symptom/complaint
2.5
12.8
97
454
M01AH02
ATC
rofecoxib; oral
3.5
12.8
46
142
M02AA07
ATC
piroxicam; topical
2.3
12.5
126
669
M03BX02
ATC
tizanidine; oral
2.3
12.4
253
1783
J01.0
ICD-10 Finland
Acute maxillary sinusitis
2.4
12.0
111
567
NDM40
NOMESCO Finland
Discission of sheath of tendon of wrist or hand
48.3
12.0
14
*
N02BF01
ATC
gabapentin; oral
4.0
11.6
34
91
NG1BG
NOMESCO Finland
Knee and lower leg MRI examination with high intensity magnet
5.0
10.9
24
51
M75.0
ICD-10 Finland
Adhesive capsulitis of shoulder
5.2
10.7
22
44
M48.0
ICD-10 Finland
Spinal stenosis
3.5
10.6
38
117
M51.3
ICD-10 Finland
Other specified intervertebral disc degeneration
3.7
10.6
35
102
M51.1
ICD-10 Finland
Lumbar and other intervertebral disc disorders with radiculopathy
2.8
10.5
58
230
WX110
NOMESCO Finland
Infiltration anesthesia
2.2
10.3
287
2208
1220
FHL
Arthroscopy
4.8
10.1
23
50
NDM20
NOMESCO Finland
Excision of synovial ganglion of wrist or hand
41.2
10.0
12
*
M01AE03
ATC
ketoprofen; systemic, rectal
2.1
10.0
128
739
L03
ICPC
Low back symptom/complaint
2.2
9.9
107
578
ZXE00
NOMESCO Finland
One hour or less
2.0
9.9
152
938
P01BA02
ATC
hydroxychloroquine; oral
3.7
9.9
32
92
NG1CG
NOMESCO Finland
Knee and lower leg extensive MRI examination with high intensity magnet
8.2
9.8
21
27
ZXE10
NOMESCO Finland
More than one and less than three hours
2.1
9.6
132
781
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
2.2
9.5
100
533
SPAT1223
SPAT
Implementation of physical therapy rehabilitation plan
2.2
9.5
93
482
S43.4
ICD-10 Finland
Sprain and strain of shoulder joint
4.6
9.5
23
53
S80.0
ICD-10 Finland
Contusion of knee
3.2
9.4
38
126
R03AC02
ATC
salbutamol; inhalant
2.0
9.4
212
1487
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
2.0
9.3
139
844
A02BC05
ATC
esomeprazole; systemic
2.0
9.3
145
895
M79.1
ICD-10 Finland
Myalgia
2.6
9.2
56
233
ZXA00
NOMESCO Finland
Right side
2.3
9.2
86
436
M01AB55
ATC
diclofenac, combinations; oral
4.4
9.0
23
55
ZXA05
NOMESCO Finland
Left side
2.3
9.0
78
383
L17
ICPC
Foot/toe symptom/complaint
2.1
9.0
102
559
NGE10
NOMESCO Finland
Incision or suture of capsule of knee joint
19.2
9.0
13
7
NGB20
NOMESCO Finland
Primary total prosthetic replacement of knee joint without patellar part
3.3
8.9
34
109
M17.0
ICD-10 Finland
Primary gonarthrosis, bilateral
2.8
8.7
45
172
NGE15
NOMESCO Finland
Incision fo capsule of knee joint, arthroscopic
51.2
8.7
10
*
M03BC01
ATC
orphenadrine (citrate); systemic
2.1
8.7
96
520
NJ2MA
NOMESCO Finland
Measurement of mechanical axis of lower leg with X-ray
4.0
8.7
25
66
NBA30
NOMESCO Finland
Exploration of joint of shoulder or upper arm, arthroscopic
16.8
8.6
13
8
M02AA10
ATC
ketoprofen; topical
2.5
8.5
58
255
TNX10
NOMESCO Finland
Arthrocentesis, unspecified region, unspecified region
3.9
8.5
25
67
N02BE01
ATC
paracetamol; systemic, rectal
2.5
8.5
329
2755
NGF10
NOMESCO Finland
Total synovectomy of knee, open
92.0
8.4
9
*
WYA05
NOMESCO Finland
Emergency visit or other similar visit involving procedures
1.9
8.2
184
1270
M54.4
ICD-10 Finland
Lumbago with sciatica
2.3
8.1
65
308
NK4XE
NOMESCO Finland
Joint ultrasound examination not elsewhere classified
3.5
8.1
28
84
J01AA02
ATC
doxycycline; systemic
2.0
8.1
278
2196
A02BC02
ATC
pantoprazole; systemic
1.9
8.1
231
1717
ZXD10
NOMESCO Finland
Scheduled procedure
1.9
8.0
134
839
ACC59
NOMESCO Finland
Decompression and freeing of adhesions of peripheral nerve: other or unspecified
6.8
8.0
19
29
ZXD20
NOMESCO Finland
Day surgery
2.5
7.9
51
219
ABC36
NOMESCO Finland
Decompression of lumbar nerve roots
4.3
7.8
20
48
M01AH03
ATC
valdecoxib; oral
3.8
7.7
24
67
J01DB01
ATC
cefalexin; oral
2.2
7.7
314
2610
X58
ICD-10 Finland
Exposure to other specified factors
2.4
7.7
57
261
Z01.8
ICD-10 Finland
Other specified special examinations
2.2
7.7
74
379
H02AB04
ATC
methylprednisolone; systemic
2.5
7.7
51
222
DJD20
NOMESCO Finland
Plastic repair of septum of nose
4.0
7.6
22
58
ZZH21
NOMESCO Finland
Graft of patients own bone, small pieces
12.2
7.6
13
11
WX408
NOMESCO Finland
General anesthesy, balanced
2.0
7.4
94
533
W22
ICD-10 Finland
Striking against or struck by other object(s)
3.0
7.4
34
122
D07AD01
ATC
clobetasol; topical
2.3
7.3
62
301
S60.0
ICD-10 Finland
Contusion of finger(s) without damage to nail
3.7
7.3
23
65
J01FA09
ATC
clarithromycin; systemic
1.9
7.2
118
730
NBG10
NOMESCO Finland
Acromioplastia
30.6
7.2
9
*
M09AX01
ATC
hyaluronic acid; parenteral
5.8
7.2
19
34
M70.6
ICD-10 Finland
Trochanteric bursitis
2.9
7.1
35
130
L04AX03
ATC
methotrexate; systemic
2.7
7.1
38
148
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
2.7
7.0
40
161
S06.0
ICD-10 Finland
Concussion
2.6
7.0
43
180
NBT60
NOMESCO Finland
Forcible manipulation of humeroscapular joint
40.8
6.8
8
*
NGF20
NOMESCO Finland
Operation for osteochondritis of knee, open
23.0
6.7
9
*
R20.2
ICD-10 Finland
Paraesthesia of skin
3.1
6.7
28
95
M01AB01
ATC
indometacin; systemic, rectal
3.4
6.7
24
74
M53.1
ICD-10 Finland
Cervicobrachial syndrome
2.4
6.7
47
210
ND2AA
NOMESCO Finland
Hand and fingers X-ray examination
2.7
6.6
36
142
ND2DA
NOMESCO Finland
Bilateral hand X-ray examination
10.3
6.6
12
12
TNX32
NOMESCO Finland
Custom moulded splint, unspecified region
3.8
6.6
20
55
NG1BG, ,
SPAT
3.3
6.4
24
76
A01
ICPC
Pain general/multiple sites
2.9
6.4
30
109
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
2.9
6.4
30
109
A07EC01
ATC
sulfasalazine; oral, rectal
2.9
6.4
30
109
X59
ICD-10 Finland
Exposure to unspecified factor
2.1
6.4
68
361
TNX00
NOMESCO Finland
Puncture and needle biopsy of soft tissue, unspecified region
11.3
6.3
11
10
NDA30
NOMESCO Finland
Exploration of joint of wrist or hand, arthroscopic
18.4
6.3
9
5
M01AE01
ATC
ibuprofen; systemic, rectal
2.7
6.3
352
3137
M79.0
ICD-10 Finland
Rheumatism, unspecified
27.2
6.3
8
*
M50.1
ICD-10 Finland
Cervical disc disorder with radiculopathy
3.6
6.2
20
57
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
1.9
6.2
85
493
R51.80
ICD-10 Finland
Headache
2.1
6.2
62
321
S46.0
ICD-10 Finland
Injury of muscle(s) and tendon(s) of the rotator cuff of shoulder
3.2
6.2
24
78
R03DC03
ATC
montelukast; oral
2.1
6.1
66
351
M65.3
ICD-10 Finland
Trigger finger
6.9
6.1
14
21
R06AE07
ATC
cetirizine; oral
1.7
6.0
163
1158
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
91
437
2.42
11.24
1.4
1.2
15.70
36.63
iu/ml
2.38
35
140
84
412
2.33
9.78
1.4
1.2
15.30
10.91
u/ml
0.13
27
179
20
43
4.85
8.93
1.7
1.4
—
—
—
0
0
264
2030
1.99
8.58
4.7
3.4
9.78
9.92
mm/h
0.06
254
1891
103
627
1.88
6.52
2.4
2.7
321.98
8820.75
umol/l
3.33
94
566
201
1535
1.66
5.51
4.0
4.7
6.61
6.58
mmol/l
0.06
188
1399
317
2744
1.95
5.50
4.9
4.2
1.81
1.83
mu/l
0.13
295
2542
271
2251
1.72
5.26
4.2
3.7
14.64
14.45
pmol/l
0.66
254
2064
341
3047
2.19
5.14
13.4
10.5
19.51
22.72
mg/l
1.02
268
2295
339
3043
2.08
4.72
12.8
11.6
139.72
139.68
mmol/l
0.10
330
2960
179
1374
1.57
4.49
5.4
5.7
29.85
29.00
%
0.49
169
1303
36
174
2.18
4.28
2.2
2.4
6.92
11.28
au/ml
—
6
12
338
3058
1.97
4.18
13.0
11.7
3.95
3.94
mmol/l
0.41
329
2966
138
1012
1.57
4.15
4.8
4.8
37.31
36.45
g/l
1.14
133
957
175
1354
1.54
4.14
5.8
5.5
56.63
56.50
%
0.05
164
1280
78
496
1.72
4.12
1.4
1.4
19.42
20.47
nmol/l
0.29
69
429
14
43
3.34
3.94
2.2
2.5
5.11
4.90
kpa
0.52
14
43
21
84
2.59
3.78
1.7
1.8
—
—
—
0
0
142
1076
1.51
3.57
6.4
9.1
1.08
1.16
inr
0.91
52
332
96
670
1.58
3.49
1.4
1.2
2.37
2.00
u/ml
0.10
23
186
42
235
1.89
3.38
3.3
2.8
—
—
—
0
0
170
1349
1.47
3.36
5.0
6.5
10.50
10.56
umol/l
0.04
164
1291
164
1302
1.46
3.19
2.6
2.5
—
—
—
0
0
111
816
1.51
3.17
2.0
2.3
53.11
60.32
u/l
1.38
104
766
122
917
1.49
3.12
1.9
1.7
100.41
95.64
pmol/l
0.57
72
471
84
583
1.57
3.11
1.6
1.7
0.71
1.03
mg/l
1.44
61
428
36
197
1.91
3.11
3.2
2.5
71.60
68.86
ml/min/173m2
—
5
78
17
68
2.57
3.08
1.4
1.3
391.50
358.51
ug/g
0.27
12
36
13
46
2.89
2.95
2.2
1.2
—
—
—
0
0
150
1191
1.43
2.84
7.0
7.3
1.23
1.21
mmol/l
2.70
127
1016
54
345
1.66
2.79
1.8
1.8
—
—
—
0
0
21
99
2.19
2.70
1.9
1.6
—
—
—
0
0
163
1323
1.41
2.69
2.8
2.6
96.38
116.97
ug/l
0.81
156
1220
27
142
1.97
2.63
2.0
2.9
108.32
115.82
ng/l
0.07
19
129
23
114
2.08
2.62
1.8
2.6
39.13
38.46
u/l
0.07
23
105
92
676
1.48
2.59
2.0
2.0
135.64
204.18
u/l
1.51
92
633
47
296
1.67
2.57
1.8
2.3
23.25
24.18
%
0.23
41
258
12
44
2.78
2.57
2.0
1.3
—
1.05
—
0
6
134
1058
1.41
2.56
5.5
6.6
1.23
1.21
mmol/l
1.87
125
969
117
903
1.43
2.54
2.8
2.9
38.41
31.89
ng/l
0.21
68
529
137
1091
1.40
2.48
2.5
2.2
74.52
73.72
nmol/l
0.14
132
1006
18
83
2.23
2.45
1.6
1.9
—
—
—
0
0
11
38
2.95
2.43
1.1
1.1
—
—
—
0
0
63
433
1.55
2.42
3.6
3.1
156.71
444.47
ng/l
1.16
39
316
315
2899
1.51
2.37
10.9
9.4
89.90
88.38
ml/min/173m2
0.70
267
2355
20
98
2.10
2.36
1.3
1.7
—
—
—
0
0
243
2137
1.38
2.35
7.4
7.0
70.72
76.29
u/l
2.26
234
2022
15
66
2.33
2.27
1.8
1.2
—
3.60
—
0
11
316
2918
1.50
2.26
4.0
3.7
5.95
5.80
mmol/l
0.67
297
2711
40
253
1.65
2.17
2.3
2.1
13.13
13.86
nmol/l
0.27
35
236
369
3555
2.44
2.15
18.2
15.7
40.49
40.82
%
0.41
347
3363
18
89
2.07
2.09
1.9
2.1
—
—
—
0
0
24
133
1.86
2.04
6.4
8.8
24.29
24.87
mmol/l
0.27
24
133
6
15
4.05
2.04
1.0
1.2
—
—
—
0
0
8
26
3.12
2.02
1.9
2.3
—
—
—
0
0
190
1632
1.33
2.02
7.9
9.3
4.19
4.00
e9/l
0.54
167
1425
247
2205
1.35
2.01
3.2
2.9
37.90
46.85
u/l
2.49
236
2097
349
3314
1.67
1.98
9.8
8.6
28.61
27.98
u/l
0.23
338
3214
7
21
3.38
1.97
1.0
1.1
99.00
77.57
umol/l
—
7
21
6
16
3.79
1.94
1.0
1.2
—
—
—
0
0
89
687
1.39
1.89
3.7
2.6
0.16
0.40
e6/l
2.01
72
503
28
168
1.72
1.86
2.0
1.5
—
—
—
0
0
13
59
2.25
1.86
1.5
1.3
—
—
—
0
0
78
594
1.39
1.79
2.4
2.0
2.35
2.83
mg/l
1.70
68
490
260
2360
1.32
1.76
3.6
3.3
—
—
—
0
0
316
2955
1.42
1.76
3.9
3.5
1.40
1.30
mmol/l
1.68
296
2779
326
3066
1.45
1.75
4.2
3.9
4.79
4.77
mmol/l
0.18
306
2909
298
2762
1.37
1.73
13.0
12.8
14.36
14.31
%
0.05
290
2719
325
3057
1.44
1.72
4.1
3.8
1.40
1.46
mmol/l
1.67
306
2890
5
13
3.88
1.72
1.2
1.2
—
—
—
0
0
292
2702
1.35
1.68
4.9
4.7
38.65
38.74
mmol/mol
0.06
275
2557
12
56
2.18
1.63
1.6
1.9
—
—
—
0
0
5
14
3.60
1.62
1.0
1.1
—
—
—
0
0
5
14
3.60
1.62
4.0
4.9
55.40
118.86
nmol/l
—
5
14
35
235
1.54
1.53
1.7
1.7
—
—
—
0
0
101
820
1.32
1.53
2.5
3.5
2.36
2.35
mmol/l
0.19
89
740
35
236
1.53
1.51
1.7
1.6
—
—
—
0
0
327
3099
1.40
1.47
4.4
4.1
2.95
2.87
mmol/l
0.86
307
2924
33
476
0.66
1.45
2.7
2.7
0.51
0.70
ug/l
1.67
18
279
5
17
2.97
1.36
3.2
1.2
—
—
—
0
0
107
889
1.28
1.36
3.6
2.7
—
—
—
0
0
86
695
1.31
1.34
1.7
1.5
—
—
—
0
0
49
365
1.39
1.30
1.6
1.5
1119.17
1135.22
nmol/l
0.05
40
268
10
190
0.51
1.28
1.3
1.5
—
—
—
0
0
8
35
2.31
1.27
1.8
1.4
—
—
—
0
0
8
35
2.31
1.27
1.8
1.4
—
—
—
0
0
8
36
2.25
1.25
1.8
1.4
—
—
—
0
0
8
36
2.25
1.25
1.8
1.4
—
—
—
0
0
8
36
2.25
1.25
1.8
1.4
—
—
—
0
0
5
112
0.44
1.15
3.4
2.3
0.68
0.66
%
—
5
112
5
114
0.43
1.14
3.6
2.4
1.00
1.26
%
—
5
114
10
51
1.99
1.12
1.9
1.2
—
—
—
0
0
72
583
1.29
1.11
3.4
2.9
1.02
1.02
kg/l
0.47
15
79
25
169
1.51
1.10
1.1
1.0
—
—
—
0
0
5
21
2.40
1.09
1.0
1.6
—
—
—
0
0
5
21
2.40
1.09
1.0
1.4
5.30
6.73
mmol/l
—
5
21
17
263
0.63
1.06
1.5
1.5
—
—
—
0
0
152
1348
1.21
1.05
3.3
2.9
0.00
0.00
estimate
0.50
32
259
84
709
1.24
0.93
4.0
3.7
10.19
10.64
mg/mmol
0.03
56
460
58
469
1.28
0.92
1.4
1.8
1.32
1.38
%
0.31
49
423
46
578
0.77
0.91
1.7
1.5
—
—
—
0
0
19
128
1.51
0.87
1.8
1.7
—
—
—
0
0
6
30
2.02
0.87
1.0
1.3
—
—
—
0
0
8
44
1.84
0.86
3.6
1.5
—
—
—
0
0
8
45
1.79
0.84
2.8
2.0
118.75
136.19
g/l
—
8
36
28
207
1.38
0.82
3.8
3.7
1.80
1.55
mmol/l
0.10
20
165
0
24
0.00
0.79
0.0
1.3
—
—
—
0
0
0
25
0.00
0.79
0.0
2.1
—
—
—
0
0
12
74
1.64
0.79
1.2
1.1
—
—
—
0
0
20
141
1.44
0.76
1.8
1.3
—
—
—
0
0
9
53
1.71
0.76
1.0
1.2
—
—
—
0
0
9
54
1.68
0.75
2.1
2.3
26.89
24.89
mmol/l
—
9
54
149
1353
1.17
0.75
4.4
4.1
0.00
0.00
estimate
-0.00
35
250
49
400
1.26
0.74
3.7
2.8
2.44
2.43
mmol/l
0.43
40
351
11
169
0.64
0.70
1.6
1.5
—
—
—
0
0
150
1369
1.16
0.70
3.3
2.9
0.00
0.00
estimate
-0.00
33
239
12
77
1.58
0.69
1.5
1.3
—
—
—
0
0
7
43
1.64
0.67
2.4
1.7
—
—
—
0
0
5
29
1.73
0.64
1.0
1.8
—
—
—
0
0
29
226
1.31
0.63
1.2
1.3
113.14
174.51
iu/ml
—
9
98
18
130
1.40
0.62
1.4
2.6
0.33
0.13
e6/l
0.65
18
125
8
50
1.61
0.61
3.6
3.1
55.00
56.00
%
—
8
50
8
51
1.58
0.61
1.1
1.4
20.46
24.44
u/l
—
8
46
0
20
0.00
0.60
0.0
1.3
—
—
—
0
0
47
394
1.22
0.58
3.1
2.4
3.03
2.43
e6/l
0.26
29
204
0
23
0.00
0.58
0.0
1.3
—
—
—
0
0
6
36
1.68
0.57
2.0
1.4
—
—
—
0
0
76
669
1.17
0.56
3.8
3.2
0.00
0.00
estimate
0.50
33
247
37
305
1.24
0.54
2.4
2.6
6.07
6.90
umol/l
0.28
32
257
6
39
1.55
0.53
1.0
1.1
—
—
—
0
0
7
109
0.64
0.49
2.4
3.6
49.04
51.69
%
—
7
109
37
309
1.22
0.49
4.2
3.8
31.29
31.21
%
0.02
28
219
56
490
1.17
0.46
1.6
1.6
484.19
9217013.09
pmol/l
0.50
48
434
35
411
0.84
0.42
1.5
1.7
—
—
—
0
0
8
59
1.36
0.41
1.1
1.5
5.63
7.32
mmol/l
—
8
51
7
101
0.69
0.40
1.4
1.8
—
—
—
0
0
5
35
1.43
0.39
1.0
1.4
237.80
179.96
pmol/l
—
5
35
0
19
0.00
0.39
0.0
1.2
—
—
—
0
0
59
526
1.14
0.39
2.4
3.2
896.25
897.88
ng/l
0.00
47
422
116
1080
1.11
0.38
3.4
3.0
—
—
—
0
0
12
157
0.76
0.36
1.6
1.4
—
—
—
0
0
12
157
0.76
0.36
1.6
1.4
—
—
—
0
0
12
157
0.76
0.36
1.6
1.4
—
—
—
0
0
12
157
0.76
0.36
1.6
1.4
—
—
—
0
0
6
41
1.47
0.36
1.2
1.0
1.50
1.41
g/l
—
6
35
6
43
1.40
0.35
1.0
1.1
—
—
—
0
0
84
772
1.11
0.35
3.9
4.0
1.28
2.26
ug/l
1.52
77
701
58
643
0.88
0.35
3.7
3.6
25.85
21.07
%
0.78
20
264
47
417
1.15
0.34
3.0
2.3
0.24
0.96
e6/l
4.66
29
224
6
87
0.68
0.33
1.3
1.5
—
—
—
0
0
7
57
1.23
0.29
2.6
1.6
—
—
—
0
0
9
119
0.75
0.27
1.2
1.4
—
—
—
0
0
29
254
1.15
0.26
6.8
10.7
0.24
1.09
mmol/l
0.42
21
198
15
180
0.83
0.24
1.0
1.3
—
—
—
0
0
6
85
0.70
0.24
7.8
3.2
35.33
2605.61
u/ml
—
6
73
70
652
1.09
0.23
2.6
2.1
—
—
—
0
0
25
283
0.88
0.22
5.8
5.9
—
—
—
0
0
5
42
1.19
0.21
1.0
1.0
—
—
—
0
0
0
11
0.00
0.21
0.0
1.2
—
—
—
0
0
0
10
0.00
0.21
0.0
1.9
—
67.46
—
0
10
0
12
0.00
0.21
0.0
1.2
—
—
—
0
0
0
14
0.00
0.20
0.0
2.4
—
—
—
0
0
10
120
0.83
0.17
1.6
1.4
—
—
—
0
0
8
73
1.10
0.16
2.6
2.4
—
—
—
0
0
7
88
0.79
0.14
1.0
1.1
—
—
—
0
0
10
118
0.84
0.14
1.4
1.6
—
—
—
0
0
27
247
1.10
0.14
2.3
1.9
—
—
—
0
0
14
122
1.15
0.14
7.5
12.7
22.93
24.60
mmol/l
0.93
14
117
15
132
1.14
0.13
1.3
1.4
132.74
251.60
miu/ml
—
9
67
13
146
0.89
0.10
1.2
1.6
—
—
—
0
0
29
310
0.93
0.10
2.3
2.0
—
—
—
0
0
5
44
1.14
0.10
1.4
1.0
—
—
—
0
0
5
48
1.04
0.09
1.8
1.8
—
—
—
0
0
5
48
1.04
0.09
1.8
1.8
—
—
—
0
0
6
57
1.05
0.08
4.5
4.4
26.10
59.05
mg/l
—
6
45
6
57
1.05
0.08
4.5
4.4
19.13
28.83
mg/l
—
6
46
6
57
1.05
0.08
4.5
4.2
—
1.18
—
0
6
7
65
1.08
0.08
5.4
1.8
—
—
—
0
0
7
67
1.05
0.08
1.6
1.7
—
—
—
0
0
14
128
1.10
0.07
9.1
12.4
95.46
93.92
%
1.38
14
128
16
166
0.96
0.00
1.1
2.3
17572.40
2408.50
u/l
—
5
71
17
176
0.96
0.00
3.3
3.0
4.69
4.72
kpa
0.04
17
170
48
482
1.00
0.00
1.5
2.0
—
—
—
0
0
54
541
1.00
0.00
1.8
2.1
—
—
—
0
0
76
764
0.99
0.00
1.6
1.6
1.55
1.42
mmol/l
0.63
63
654
8
88
0.91
0.00
1.0
1.1
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
5
51
0.98
-0.00
1.8
1.7
—
—
—
0
0
0
9
0.00
-0.00
0.0
5.1
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.0
—
—
—
0
0
7
70
1.00
-0.00
1.7
1.7
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.3
—
—
—
0
0
7
78
0.90
-0.00
1.3
1.3
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint M13_SYNOHYPERTROPH and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_SYNOHYPERTROPH | 0.855 [0.66, 1.11] | 0.242 |
| Birth year | 0.99 [0.98, 1.0] | 0.031 |
During the follow-up period (1.1.1998 — 31.12.2019), 52 out of 1348 females with M13_SYNOHYPERTROPH died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_SYNOHYPERTROPH | 0.647 [0.51, 0.83] | < 0.001 |
| Birth year | 0.989 [0.98, 1.0] | 0.015 |
During the follow-up period (1.1.1998 — 31.12.2019), 65 out of 1281 males with M13_SYNOHYPERTROPH died.
Mortality risk
Mortality risk for people of age
years, who have M13_SYNOHYPERTROPH.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.068% | 0.126% |
| 5 | 0.399% | 0.722% |
| 10 | 0.962% | 1.892% |
| 15 | 1.923% | 3.781% |
| 20 | 3.398% | 6.383% |
Relationships between endpoints
↥Index endpoint: M13_SYNOHYPERTROPH – Synovial hypertrophy, not elsewhere classified
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data