No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
376 |
4. Check minimum number of eventsNone |
376 |
5. Include endpointsNone |
376 |
6. Filter based on genotype QC (FinnGen only) |
376 |
Control definitions (FinnGen only)
- Control exclude
- M13_SOFTTISSUE
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- M67
- Name in latin
- Hypertrophia membranae synovialis non alibi classificata
Similar endpoints
↥List of similar endpoints to
Synovial hypertrophy, not elsewhere classified
based on the number of shared cases.
Similar with more cases:
- Disorders of synovium and tendon
- Soft tissue disorders
- Diseases of the musculoskeletal system and connective tissue
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 3056 | 1552 | 1498 |
| Only index persons | 3008 | 1538 | 1470 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.04 | 0.04 | 0.04 |
| Only index persons | 0.06 | 0.06 | 0.06 |
| Median age at first event (years) | |||
| Whole population | 36.05 | 35.31 | 36.81 |
| Only index persons | 36.00 | 35.29 | 36.74 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 376 | 221 | 155 |
| Unadjusted period prevalence (%) | 0.07 | 0.08 | 0.07 |
| Median age at first event (years) | 38.14 | 36.49 | 40.48 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 343
- Matched controls
- 3430
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
M67.2
ICD-10 Finland
Synovial hypertrophy, not elsewhere classified
+∞
323.0
343
*
NGF00
NOMESCO Finland
Excision of plica of synovy of knee
127.4
142.8
147
20
NGF25
NOMESCO Finland
Operation for osteochondritis of knee, arthroscopic
17.6
55.8
91
69
M23.2
ICD-10 Finland
Derangement of meniscus due to old tear or injury
9.1
42.7
98
145
NGF15
NOMESCO Finland
Total synovectomy of knee, arthroscopic
61.2
37.3
43
8
NGA30
NOMESCO Finland
Exploration of knee joint, arthroscopic
13.3
33.9
61
55
M22.4
ICD-10 Finland
Chondromalacia patellae
15.9
31.5
52
38
NGD05
NOMESCO Finland
Partial excision of meniscus of knee, arthroscopic
6.8
30.9
85
159
M25.5
ICD-10 Finland
Pain in joint
4.2
29.5
142
493
M79.6
ICD-10 Finland
Pain in limb
3.9
25.9
136
497
M17.1
ICD-10 Finland
Other primary gonarthrosis
5.1
25.9
92
231
M01AH05
ATC
etoricoxib; oral
3.1
21.1
234
1410
M01AX05
ATC
glucosamine; oral
4.4
19.1
75
204
NBG15
NOMESCO Finland
Acromioplastia, arthroscopic
20.2
19.0
28
15
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
2.8
18.5
183
992
N02AX02
ATC
tramadol; systemic, rectal
2.9
17.9
149
720
M23.8
ICD-10 Finland
Other internal derangements of knee
9.9
17.9
36
40
M01AB05
ATC
diclofenac; systemic, rectal
2.8
17.4
250
1671
N03AX12
ATC
gabapentin; oral
4.2
15.9
65
182
M23.9
ICD-10 Finland
Internal derangement of knee, unspecified
5.1
15.9
52
116
S83.2
ICD-10 Finland
Tear of meniscus, current
5.3
14.8
46
97
N02AJ06
ATC
codeine and paracetamol; systemic
2.6
14.5
146
766
M67.4
ICD-10 Finland
Ganglion
10.1
14.2
28
30
M75.1
ICD-10 Finland
Rotator cuff syndrome
3.4
14.0
73
250
M75.4
ICD-10 Finland
Impingement syndrome of shoulder
11.6
13.7
25
23
NDM40
NOMESCO Finland
Discission of sheath of tendon of wrist or hand
+∞
13.6
13
*
M67.8
ICD-10 Finland
Other specified disorders of synovium and tendon
145.5
13.5
14
*
S18
ICPC
Laceration/cut
2.5
13.2
141
753
M01AX17
ATC
nimesulide; oral
3.0
12.8
85
344
M01AE02
ATC
naproxen; oral, rectal
2.3
12.7
210
1388
M19.0
ICD-10 Finland
Primary arthrosis of other joints
5.4
12.6
38
77
M03BX02
ATC
tizanidine; oral
2.3
12.5
229
1585
S83.6
ICD-10 Finland
Sprain and strain of other and unspecified parts of knee
5.7
12.2
35
67
L15
ICPC
Knee symptom/complaint
3.0
11.7
74
289
NDM20
NOMESCO Finland
Excision of synovial ganglion of wrist or hand
124.0
11.5
12
*
M01AC06
ATC
meloxicam; systemic, rectal
2.4
11.2
124
662
NBA30
NOMESCO Finland
Exploration of joint of shoulder or upper arm, arthroscopic
44.8
11.0
13
*
NGF35
NOMESCO Finland
Plastic operation of joint cartilage of knee
8.4
10.8
23
29
M02AA07
ATC
piroxicam; topical
2.4
10.8
118
624
N03AX16
ATC
pregabalin; oral
2.8
10.7
79
336
M54.5
ICD-10 Finland
Low back pain
2.3
10.1
116
625
G56.0
ICD-10 Finland
Carpal tunnel syndrome
3.3
10.0
52
176
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
4.5
9.9
35
85
M01AH01
ATC
celecoxib; oral (coxibs)
2.9
9.8
64
254
NG1AA
NOMESCO Finland
Knee X-ray examination without contrast
3.9
9.7
40
112
H02AB06
ATC
prednisolone; systemic
2.1
9.7
153
948
L03
ICPC
Low back symptom/complaint
2.5
9.6
83
386
M17.0
ICD-10 Finland
Primary gonarthrosis, bilateral
3.8
9.6
40
114
M01AH02
ATC
rofecoxib; oral
3.5
9.4
44
138
ZXE10
NOMESCO Finland
More than one and less than three hours
2.1
9.2
127
738
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
2.2
9.1
120
684
M01AE01
ATC
ibuprofen; systemic, rectal
3.2
9.1
320
2781
NGE10
NOMESCO Finland
Incision or suture of capsule of knee joint
37.8
9.1
11
*
N02BE01
ATC
paracetamol; systemic, rectal
2.3
9.0
285
2325
1220
FHL
Arthroscopy
6.2
8.9
23
39
ZXA00
NOMESCO Finland
Right side
2.4
8.8
81
387
M77.1
ICD-10 Finland
Lateral epicondylitis
4.0
8.5
33
88
ZXE00
NOMESCO Finland
One hour or less
2.0
8.4
142
890
NGF10
NOMESCO Finland
Total synovectomy of knee, open
+∞
8.4
8
*
NBT60
NOMESCO Finland
Forcible manipulation of humeroscapular joint
+∞
8.4
8
*
NG1CG
NOMESCO Finland
Knee and lower leg extensive MRI examination with high intensity magnet
7.1
8.2
19
28
M01AE03
ATC
ketoprofen; systemic, rectal
2.1
8.1
115
669
WX320
NOMESCO Finland
Spinalanesthesy
2.4
8.1
77
375
M02AA10
ATC
ketoprofen; topical
2.8
7.9
52
204
M51.1
ICD-10 Finland
Lumbar and other intervertebral disc disorders with radiculopathy
2.8
7.9
50
194
J01AA02
ATC
doxycycline; systemic
2.0
7.7
256
2038
J01.0
ICD-10 Finland
Acute maxillary sinusitis
2.2
7.7
88
466
R03AC02
ATC
salbutamol; inhalant
1.9
7.6
179
1254
WX110
NOMESCO Finland
Local anesthesy
1.9
7.5
244
1917
A02BC05
ATC
esomeprazole; systemic
2.0
7.5
127
790
S43.4
ICD-10 Finland
Sprain and strain of shoulder joint
7.1
7.4
17
25
M03BC01
ATC
orphenadrine (citrate); systemic
2.1
7.2
91
502
ACC59
NOMESCO Finland
Decompression and freeing of adhesions of peripheral nerve: other or unspecified
6.8
7.2
17
26
S60.0
ICD-10 Finland
Contusion of finger(s) without damage to nail
5.9
7.2
19
34
NGE15
NOMESCO Finland
Incision fo capsule of knee joint, arthroscopic
20.5
7.2
10
5
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
2.1
7.1
88
479
ZXD20
NOMESCO Finland
Day surgery
2.7
7.1
48
193
M48.0
ICD-10 Finland
Spinal stenosis
3.5
7.1
32
98
M09AX01
ATC
hyaluronic acid; parenteral
5.7
7.0
19
35
M79.5
ICD-10 Finland
Residual foreign body in soft tissue
14.1
6.9
11
8
M75.0
ICD-10 Finland
Adhesive capsulitis of shoulder
6.3
6.9
17
28
J45.9
ICD-10 Finland
Asthma, unspecified
2.5
6.8
55
244
ZXD10
NOMESCO Finland
Scheduled procedure
1.9
6.8
126
801
NGF20
NOMESCO Finland
Operation for osteochondritis of knee, open
40.9
6.8
8
*
M94.2
ICD-10 Finland
Chondromalacia
17.1
6.8
10
6
M53.1
ICD-10 Finland
Cervicobrachial syndrome
2.8
6.7
43
168
NBG10
NOMESCO Finland
Acromioplastia
23.0
6.7
9
*
ZXA05
NOMESCO Finland
Left side
2.2
6.7
72
367
R51.80
ICD-10 Finland
Headache
2.5
6.7
54
239
SPAT1223
SPAT
Implementation of physical therapy rehabilitation plan
2.1
6.6
80
432
NJ2MA
NOMESCO Finland
Measurement of mechanical axis of lower leg with X-ray
4.4
6.6
22
52
L17
ICPC
Foot/toe symptom/complaint
2.2
6.6
73
378
TNX10
NOMESCO Finland
Arthrocentesis, unspecified region, unspecified region
3.8
6.2
25
70
J01DB01
ATC
cefalexin; oral
2.0
6.2
277
2337
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
2.3
6.2
59
287
ND2AA
NOMESCO Finland
Hand and fingers X-ray examination
3.2
6.1
30
99
L08
ICPC
Shoulder symptom/complaint
2.4
6.1
53
245
TNX00
NOMESCO Finland
Puncture and needle biopsy of soft tissue, unspecified region
10.3
6.1
11
11
W22
ICD-10 Finland
Striking against or struck by other object(s)
3.3
6.1
29
94
Mortality – FinRegistry
↥Association
Association between endpoint M13_SYNOHYPERTROPH and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_SYNOHYPERTROPH | 0.855 [0.66, 1.11] | 0.242 |
| Birth year | 0.99 [0.98, 1.0] | 0.031 |
During the follow-up period (1.1.1998 — 31.12.2019), 52 out of 1348 females with M13_SYNOHYPERTROPH died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_SYNOHYPERTROPH | 0.647 [0.51, 0.83] | < 0.001 |
| Birth year | 0.989 [0.98, 1.0] | 0.015 |
During the follow-up period (1.1.1998 — 31.12.2019), 65 out of 1281 males with M13_SYNOHYPERTROPH died.
Mortality risk
Mortality risk for people of age
years, who have M13_SYNOHYPERTROPH.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.068% | 0.126% |
| 5 | 0.399% | 0.722% |
| 10 | 0.962% | 1.892% |
| 15 | 1.923% | 3.781% |
| 20 | 3.398% | 6.383% |
Relationships between endpoints
↥Index endpoint: M13_SYNOHYPERTROPH – Synovial hypertrophy, not elsewhere classified
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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