Transient synovitis

M13_TRANSSYNOVITIS

synovitis: ['Inflammation of the SYNOVIAL MEMBRANE [ MeSH ]']

Endpoint definition

↥

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — M67.3 Cause of death: ICD-10 — M67.3 2 out of 7 registries used, show all original rules.	328
4. Check minimum number of events None	328
5. Include endpoints None	328
6. Filter based on genotype QC (FinnGen only)	328

Control definitions (FinnGen only)

Control exclude: M13_SOFTTISSUE

Extra metadata

Level in the ICD hierarchy: 4
First used in FinnGen datafreeze: DF2
Parent code in ICD-10: M67
Name in latin: Synovitis transitoria

NAME	M13_TRANSSYNOVITIS
CONTROL_EXCLUDE	M13_SOFTTISSUE
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	M673
HD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	M673
COD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Transient synovitis based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	4739	1722	3013
Only index persons	3886	1464	2422
Unadjusted period prevalence (%)
Whole population	0.07	0.05	0.08
Only index persons	0.08	0.05	0.09
Median age at first event (years)
Whole population	6.89	8.17	6.11
Only index persons	8.02	10.50	6.51

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	328	191	137
Unadjusted period prevalence (%)	0.06	0.07	0.06
Median age at first event (years)	23.78	30.04	15.06

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
286: Matched controls
2859

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

M67.3

ICD-10 Finland

Transient synovitis

+∞

323.0

286

M67.4

ICD-10 Finland

Ganglion

31.6

31.2

M25.5

ICD-10 Finland

Pain in joint

4.9

28.3

112

330

NDM40

NOMESCO Finland

Discission of sheath of tendon of wrist or hand

+∞

20.0

M65.3

ICD-10 Finland

Trigger finger

27.6

17.2

NDM20

NOMESCO Finland

Excision of synovial ganglion of wrist or hand

180.1

16.7

M13.9

ICD-10 Finland

Arthritis, unspecified

7.8

16.3

NBG15

NOMESCO Finland

Acromioplastia, arthroscopic

40.5

15.6

202

Kela drug reimbursment

Connective tissue diseases, rheumatoid arthritis and comparable disease

4.8

13.9

115

NF1AE

NOMESCO Finland

Hip joint ultrasound examination

13.0

13.9

L04AX03

ATC

methotrexate; systemic (immunosuppressants)

5.3

13.2

TNX10

NOMESCO Finland

Arthrocentesis, unspecified region, unspecified region

6.2

12.9

M79.6

ICD-10 Finland

Pain in limb

3.0

12.8

355

NGA30

NOMESCO Finland

Exploration of knee joint, arthroscopic

10.0

12.8

NGF15

NOMESCO Finland

Total synovectomy of knee, arthroscopic

45.2

11.0

313

Kela drug reimbursment

Abatacept, adalimumab, anakinra, certolizumab pegol, etanercept, golimumab, infliximab, ixekizumab, sarilumab, secukinumab, tocilizumab and ustekinumab (rheumatoid diseases)

9.1

10.8

N06AA09

ATC

amitriptyline; systemic

6.4

10.7

NK4XE

NOMESCO Finland

Joint ultrasound examination not elsewhere classified

5.4

10.7

M65.9

ICD-10 Finland

Synovitis and tenosynovitis, unspecified

16.9

10.5

281

Kela drug reimbursment

Abatacept, adalimumab, anakinra, certolizumab pegol, etanercept, golimumab, infliximab, ixekizumab, sarilumab, secukinumab and tocilizumab

9.4

10.5

M01AH05

ATC

etoricoxib; oral

2.3

10.3

143

867

M19.0

ICD-10 Finland

Primary arthrosis of other joints

6.5

10.3

NGF00

NOMESCO Finland

Excision of plica of synovy of knee

12.8

10.0

NGF35

NOMESCO Finland

Plastic operation of joint cartilage of knee

10.6

9.7

M17.1

ICD-10 Finland

Other primary gonarthrosis

3.6

9.6

137

M75.1

ICD-10 Finland

Rotator cuff syndrome

3.7

9.3

123

M02AA07

ATC

piroxicam; topical

2.5

9.0

375

M05.8

ICD-10 Finland

Other seropositive rheumatoid arthritis

7.2

9.0

M75.4

ICD-10 Finland

Impingement syndrome of shoulder

11.2

8.9

N02AX02

ATC

tramadol; systemic, rectal

2.4

8.9

444

M65.8

ICD-10 Finland

Other synovitis and tenosynovitis

16.9

8.6

NGF25

NOMESCO Finland

Operation for osteochondritis of knee, arthroscopic

5.5

8.1

N02AJ06

ATC

codeine and paracetamol; systemic

2.2

7.9

500

A07EC01

ATC

sulfasalazine; oral, rectal

4.0

7.9

M01AC06

ATC

meloxicam; systemic, rectal

2.4

7.9

386

SPAT1153

SPAT

Removal of sutures

2.4

7.6

362

L88

ICPC

Rheumatoid/seropositive arthritis

6.8

7.5

P01BA02

ATC

hydroxychloroquine; oral

4.4

7.4

L04AA13

ATC

leflunomide; oral

11.3

7.4

G56.0

ICD-10 Finland

Carpal tunnel syndrome

3.5

7.2

N06AX21

ATC

duloxetine; oral

3.7

7.0

ZXA00

NOMESCO Finland

Right side

2.5

7.0

279

NF1AA

NOMESCO Finland

Hip X-ray examination

4.8

6.9

M01AE02

ATC

naproxen; oral, rectal

1.9

6.9

171

1242

NG1AA

NOMESCO Finland

Knee X-ray examination without contrast

3.3

6.6

105

M23.8

ICD-10 Finland

Other internal derangements of knee

6.0

6.6

M17.5

ICD-10 Finland

Other secondary gonarthrosis

14.7

6.4

M08.4

ICD-10 Finland

Pauciarticular juvenile arthritis

11.4

6.3

M01AH01

ATC

celecoxib; oral (coxibs)

3.0

6.3

132

NGF10

NOMESCO Finland

Total synovectomy of knee, open

+∞

6.3

M17.0

ICD-10 Finland

Primary gonarthrosis, bilateral

3.6

6.1

R01BA52

ATC

pseudoephedrine, combinations; oral

2.2

6.1

349

L15

ICPC

Knee symptom/complaint

2.2

6.0

320

M23.2

ICD-10 Finland

Derangement of meniscus due to old tear or injury

3.3

6.0

M01AX17

ATC

nimesulide; oral

2.6

6.0

175

Mortality – FinRegistry

↥

Association

Association between endpoint M13_TRANSSYNOVITIS and mortality.

Females

Parameter	HR [95% CI]	p-value
M13_TRANSSYNOVITIS	1.188 [0.89, 1.59]	0.244
Birth year	0.993 [0.98, 1.0]	0.098

During the follow-up period (1.1.1998 — 31.12.2019), 53 out of 1551 females with M13_TRANSSYNOVITIS died.

Males

Parameter	HR [95% CI]	p-value
M13_TRANSSYNOVITIS	1.195 [0.91, 1.56]	0.196
Birth year	0.989 [0.98, 1.0]	0.024

During the follow-up period (1.1.1998 — 31.12.2019), 71 out of 2694 males with M13_TRANSSYNOVITIS died.

Mortality risk

Mortality risk for people of age

years, who have M13_TRANSSYNOVITIS.

N-year risk	Females	Males
1	0.096%	0.247%
5	0.579%	1.482%
10	1.456%	3.667%
15	2.989%	7.022%
20	5.127%	11.837%

Relationships between endpoints

↥

Index endpoint: M13_TRANSSYNOVITIS – Transient synovitis

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

Extremity

rg [CI]

Extremity

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Transient synovitis

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

Matched cohort

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints