Transient synovitis

M13_TRANSSYNOVITIS

Endpoint definition

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

519972

1. Apply sex-specific rule

None

519972

2. Check conditions

None

519972

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 M67.3
  • Cause of death: ICD-10 M67.3

2 out of 7 registries used, show all original rules.

330

4. Check minimum number of events

None

330

5. Include endpoints

None

330

6. Filter based on genotype QC (FinnGen only)

320

Control definitions (FinnGen only)

Control exclude
M13_SOFTTISSUE

Extra metadata

Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
M67
Name in latin
Synovitis transitoria

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 4739 1722 3013
Only index persons 3886 1464 2422
Unadjusted period prevalence (%)
Whole population 0.07 0.05 0.08
Only index persons 0.08 0.05 0.09
Median age at first event (years)
Whole population 6.89 8.17 6.11
Only index persons 8.02 10.50 6.51

-FinnGen-

Key figures

All Female Male
Number of individuals 320 187 133
Unadjusted period prevalence (%) 0.06 0.07 0.06
Median age at first event (years) 22.90 30.00 12.92

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
330
Matched controls
3300
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
M67.3
ICD-10 Finland
Transient synovitis
+∞
307.7
330
*
M67.4
ICD-10 Finland
Ganglion
12.2
41.7
44
41
M25.5
ICD-10 Finland
Pain in joint
4.7
41.4
149
495
M13.9
ICD-10 Finland
Arthritis, unspecified
7.8
32.8
49
72
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
5.4
24.3
53
113
TNX10
NOMESCO Finland
Arthrocentesis, unspecified region, unspecified region
7.0
23.6
38
60
NDM40
NOMESCO Finland
Discission of sheath of tendon of wrist or hand
246.4
22.9
23
*
NF1AE
NOMESCO Finland
Hip joint ultrasound examination
17.6
20.6
32
20
A07EC01
ATC
sulfasalazine; oral, rectal
6.5
20.4
35
59
L04AX03
ATC
methotrexate; systemic
4.9
19.9
48
111
M65.3
ICD-10 Finland
Trigger finger
21.0
19.9
29
15
NGA30
NOMESCO Finland
Exploration of knee joint, arthroscopic
7.8
19.4
28
39
M79.6
ICD-10 Finland
Pain in limb
3.0
18.9
123
552
M19.0
ICD-10 Finland
Primary arthrosis of other joints
6.2
18.4
33
58
NBG15
NOMESCO Finland
Acromioplastia, arthroscopic
55.8
18.2
21
*
M75.1
ICD-10 Finland
Rotator cuff syndrome
3.8
17.6
61
186
NK4XE
NOMESCO Finland
Joint ultrasound examination not elsewhere classified
5.1
16.6
37
80
M05.8
ICD-10 Finland
Other seropositive rheumatoid arthritis
7.3
15.9
24
35
N06AA09
ATC
amitriptyline; systemic
5.5
15.9
32
63
NGF25
NOMESCO Finland
Operation for osteochondritis of knee, arthroscopic
6.0
15.4
28
50
G56.0
ICD-10 Finland
Carpal tunnel syndrome
4.2
14.7
42
111
NGF15
NOMESCO Finland
Total synovectomy of knee, arthroscopic
37.9
14.6
18
5
NDM20
NOMESCO Finland
Excision of synovial ganglion of wrist or hand
44.6
14.2
17
*
P01BA02
ATC
hydroxychloroquine; oral
5.1
14.1
31
66
NG1AA
NOMESCO Finland
Knee X-ray examination without contrast
3.9
13.8
43
121
M01AH05
ATC
etoricoxib; oral
2.4
13.5
177
1077
M02AA07
ATC
piroxicam; topical
2.7
13.3
91
409
M17.1
ICD-10 Finland
Other primary gonarthrosis
3.2
11.6
50
174
M75.4
ICD-10 Finland
Impingement syndrome of shoulder
15.8
11.4
18
12
NGF00
NOMESCO Finland
Excision of plica of synovy of knee
14.6
11.1
18
13
N02AX02
ATC
tramadol; systemic, rectal
2.3
11.0
106
554
NGF35
NOMESCO Finland
Plastic operation of joint cartilage of knee
9.7
10.7
21
23
313
Kela drug reimbursment
Abatacept, adalimumab, anakinra, certolizumab pegol, etanercept, golimumab, infliximab, ixekizumab, sarilumab, secukinumab, tocilizumab and ustekinumab (rheumatoid diseases)
8.2
10.6
23
30
M65.9
ICD-10 Finland
Synovitis and tenosynovitis, unspecified
10.1
10.4
20
21
L88
ICPC
Rheumatoid/seropositive arthritis
8.3
10.3
22
28
SPAT1230
SPAT
Aid fitting and borrowing and monitoring of use
3.1
10.2
46
164
SPAT1263
SPAT
Sampling
2.1
10.1
153
955
L15
ICPC
Knee symptom/complaint
2.4
9.9
87
434
281
Kela drug reimbursment
Abatacept, adalimumab, anakinra, certolizumab pegol, etanercept, golimumab, infliximab, ixekizumab, sarilumab, secukinumab and tocilizumab
7.8
9.9
22
30
ACC51
NOMESCO Finland
Release of median nerve
4.8
9.7
22
48
L29
ICPC
Musculoskeletal sympt/complt other
3.5
9.6
35
109
NF1AA
NOMESCO Finland
Hip X-ray examination
4.4
9.6
25
61
M23.2
ICD-10 Finland
Derangement of meniscus due to old tear or injury
3.6
9.6
33
99
M13.1
ICD-10 Finland
Monoarthritis, not elsewhere classified
31.0
9.5
12
*
J01FF01
ATC
clindamycin; systemic
2.4
9.4
79
387
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
3.8
9.3
29
81
N06AX21
ATC
duloxetine; oral
3.2
9.2
38
128
M01AC06
ATC
meloxicam; systemic, rectal
2.3
9.2
86
440
M17.0
ICD-10 Finland
Primary gonarthrosis, bilateral
3.4
9.2
34
107
N03AX12
ATC
[U] gabapentin; oral
3.0
9.1
42
151
M01AH01
ATC
celecoxib; oral
3.0
9.1
43
157
SPAT1153
SPAT
Removal of sutures
2.3
9.0
87
450
M01AE02
ATC
naproxen; oral, rectal
2.0
8.8
204
1463
R01BA52
ATC
pseudoephedrine, combinations; oral
2.3
8.8
76
376
SPAT1255
SPAT
Intravenous administration of medicine
4.4
8.6
22
53
L04AA13
ATC
[U] leflunomide
11.2
8.4
15
14
NGB20
NOMESCO Finland
Primary total prosthetic replacement of knee joint without patellar part
3.8
8.3
26
73
NGD05
NOMESCO Finland
Partial excision of meniscus of knee, arthroscopic
3.2
8.1
33
110
SPAT1229
SPAT
Assessment of need for aid
4.3
8.1
21
51
Z01.8
ICD-10 Finland
Other specified special examinations
2.3
8.1
73
366
ZXA00
NOMESCO Finland
Right side
2.3
7.9
66
320
H02AB06
ATC
prednisolone; systemic
2.0
7.9
127
793
M23.8
ICD-10 Finland
Other internal derangements of knee
4.7
7.7
18
40
M54.5
ICD-10 Finland
Low back pain
2.1
7.7
100
577
M02AA10
ATC
ketoprofen; topical
2.8
7.7
41
160
N03AX16
ATC
[U] pregabalin
2.5
7.7
52
229
L01BA01
ATC
methotrexate; systemic
8.3
7.7
16
20
M65.8
ICD-10 Finland
Other synovitis and tenosynovitis
9.2
7.6
15
17
N02AJ06
ATC
codeine and paracetamol; systemic
2.0
7.5
120
744
T81.4
ICD-10 Finland
Infection following a procedure, not elsewhere classified
3.1
7.5
32
110
T84.0
ICD-10 Finland
Mechanical complication of internal joint prosthesis
11.2
7.4
13
12
M17.5
ICD-10 Finland
Other secondary gonarthrosis
16.2
7.3
11
7
Y83
ICD-10 Finland
Surgical operation and other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
4.1
7.3
20
51
S83.2
ICD-10 Finland
Tear of meniscus, current
3.5
7.1
25
76
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.9
7.1
112
690
L17
ICPC
Foot/toe symptom/complaint
2.0
6.9
93
541
ND2AA
NOMESCO Finland
Hand and fingers X-ray examination
2.9
6.9
33
121
ZXA05
NOMESCO Finland
Left side
2.3
6.9
57
274
M08.4
ICD-10 Finland
Pauciarticular juvenile arthritis
12.6
6.6
11
9
NB1AA
NOMESCO Finland
Shoulder X-ray examination without contrast
3.7
6.5
21
60
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.1
6.4
67
354
M06.0
ICD-10 Finland
Seronegative rheumatoid arthritis
11.3
6.3
11
10
M06.9
ICD-10 Finland
Rheumatoid arthritis, unspecified
9.5
6.3
12
13
L16
ICPC
Ankle symptom/complaint
2.3
6.3
49
230
NGF10
NOMESCO Finland
Total synovectomy of knee, open
+∞
6.3
6
*
J01DA01
ATC
[U] cefalexin
1.8
6.1
173
1264
L04AB01
ATC
etanercept; parenteral
10.3
6.1
11
11
X58
ICD-10 Finland
Exposure to other specified factors
2.2
6.1
54
268
M01AX17
ATC
nimesulide; oral
2.4
6.0
45
207

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
192
1255
2.27
11.81
11.0
6.0
2.09
1.98
e9/l
1.14
179
1104
185
1197
2.24
11.59
11.1
6.0
0.56
0.56
e9/l
0.14
169
1020
183
1199
2.18
10.86
11.2
6.0
0.04
0.04
e9/l
0.06
167
1020
187
1236
2.18
10.85
11.9
6.6
0.18
0.19
e9/l
0.11
172
1072
173
1124
2.13
10.32
10.2
6.2
—
—
—
0
0
179
1179
2.13
10.29
10.9
5.9
53.91
54.77
%
0.42
172
1118
181
1198
2.13
10.27
11.0
6.0
31.52
30.79
%
0.35
174
1139
231
1681
2.25
10.25
6.3
3.4
9.66
8.90
mm/h
0.39
226
1547
68
299
2.60
10.20
1.3
1.2
15.11
12.21
u/ml
0.08
24
115
173
1140
2.09
9.77
11.4
6.4
8.29
8.47
%
0.38
166
1077
170
1129
2.04
9.23
11.3
6.1
2.69
2.83
%
0.44
162
1061
164
1091
2.00
8.70
11.6
6.3
0.61
0.67
%
0.86
156
1023
215
1579
2.04
8.54
5.5
3.7
—
—
—
0
0
197
1404
2.00
8.51
13.8
9.1
3.87
3.95
e9/l
0.18
181
1194
57
264
2.40
7.56
1.4
1.3
511.11
394.29
titre
—
9
49
222
1701
1.93
7.18
7.8
6.4
81.19
82.99
u/l
0.17
213
1593
64
324
2.21
6.88
1.3
1.2
30.52
31.31
iu/ml
0.02
16
98
173
1237
1.84
6.82
7.8
5.0
6.46
6.39
mmol/l
0.13
157
1130
38
152
2.70
6.80
4.8
3.4
—
—
—
0
0
83
475
2.00
6.44
4.8
3.8
—
—
—
0
0
159
1123
1.80
6.40
5.2
3.1
0.00
0.00
estimate
0.50
28
227
12
13
9.53
6.34
2.3
1.5
—
—
—
0
0
159
1135
1.77
6.08
5.2
3.1
0.00
0.00
estimate
-0.00
28
214
135
941
1.74
5.45
4.7
2.9
5.96
5.96
ph
0.00
13
86
155
1124
1.71
5.42
6.5
4.2
0.00
0.00
estimate
0.50
28
225
89
556
1.82
5.19
5.7
3.2
1.02
1.02
kg/l
0.09
14
79
76
454
1.88
5.10
2.9
1.8
1.06
1.14
mg/l
0.10
59
330
11
16
7.07
4.99
7.5
2.6
10.45
11.50
%
0.13
11
16
114
774
1.72
4.97
13.0
7.9
1.14
1.13
inr
0.10
40
251
51
273
2.03
4.69
2.7
2.1
—
—
—
0
0
238
1984
1.72
4.59
5.5
4.2
37.75
37.91
mmol/mol
0.09
227
1871
31
137
2.39
4.54
4.3
4.9
0.00
0.05
%
—
6
41
291
2583
2.07
4.49
17.4
10.0
22.47
22.04
mg/l
0.07
224
1879
31
138
2.38
4.47
4.0
4.3
0.17
0.71
%
—
6
46
95
629
1.72
4.47
2.7
3.0
14.32
27.90
ng/l
1.90
56
353
33
153
2.29
4.35
4.2
4.7
0.38
1.23
%
—
8
57
116
817
1.65
4.30
7.8
4.8
36.60
37.01
g/l
0.34
111
773
80
511
1.75
4.25
5.5
3.1
—
—
—
0
0
9
13
7.08
4.19
1.9
1.2
—
—
—
0
0
70
432
1.79
4.18
4.3
2.4
4.38
5.99
e6/l
0.68
62
384
90
597
1.70
4.17
5.2
3.4
0.00
0.01
estimate
0.80
28
215
30
137
2.31
4.10
1.6
1.5
—
—
—
0
0
31
144
2.27
4.08
4.4
4.8
0.17
0.19
%
—
6
48
95
643
1.67
4.07
5.6
2.9
12.48
66.26
e6/l
2.59
73
481
22
89
2.58
3.88
9.1
16.6
—
—
—
0
0
154
1187
1.56
3.80
3.3
2.6
93.79
92.30
ug/l
0.03
149
1098
111
799
1.59
3.67
6.3
3.2
41.51
61.32
e6/l
0.28
77
521
40
215
1.98
3.64
1.4
1.4
—
—
—
0
0
92
634
1.63
3.63
3.3
2.8
—
—
—
0
0
10
21
4.88
3.58
7.5
2.3
35.96
36.71
%
—
10
21
22
93
2.46
3.57
6.0
9.1
—
—
—
0
0
261
2289
1.67
3.53
4.8
4.1
1.88
1.88
mu/l
0.03
255
2113
17
65
2.70
3.36
1.6
1.3
1.18
1.20
g/l
0.09
17
60
88
611
1.60
3.34
3.2
2.4
—
—
—
0
0
133
1017
1.52
3.28
3.0
2.5
—
—
—
0
0
34
180
1.99
3.24
8.2
11.3
0.39
1.03
mmol/l
0.64
27
146
8
15
5.44
3.21
2.5
1.7
—
—
—
0
0
61
390
1.69
3.19
2.4
2.7
179.54
144.14
ug/g
0.25
46
308
24
112
2.23
3.15
1.0
1.1
—
—
—
0
0
11
31
3.63
3.02
17.4
4.5
75.24
67.07
%
1.00
11
31
136
1065
1.47
2.91
6.5
5.9
11.86
13.03
umol/l
0.22
131
1008
19
83
2.37
2.90
9.8
4.2
0.16
0.30
g/l
—
10
48
59
389
1.63
2.74
3.7
2.6
574.36
564.01
mosm/kgh2o
0.12
47
330
126
984
1.45
2.69
13.0
7.9
1.23
1.22
mmol/l
0.76
108
859
65
442
1.59
2.66
4.4
2.6
9215.53
7672.49
umol/l
0.06
57
402
82
589
1.52
2.64
5.5
2.7
—
—
—
0
0
293
2707
1.73
2.59
13.3
7.9
27.03
26.41
u/l
0.14
288
2616
7
16
4.45
2.48
12.6
2.8
12.29
11.69
%
—
7
16
11
38
2.96
2.44
5.9
1.9
—
—
—
0
0
222
1943
1.44
2.43
4.2
3.6
14.37
14.62
pmol/l
0.90
209
1757
25
133
1.95
2.38
1.2
1.2
—
—
—
0
0
84
621
1.47
2.34
12.4
6.9
—
—
—
0
0
142
1160
1.39
2.27
14.2
7.9
0.00
0.00
e9/l
0.32
117
926
7
18
3.95
2.26
26.3
6.5
10.74
12.77
%
—
7
18
39
243
1.69
2.26
1.0
1.2
—
—
—
0
0
40
251
1.68
2.26
2.1
1.6
—
—
—
0
0
25
136
1.91
2.25
4.5
3.0
61.04
68.16
e9/l
0.52
19
101
67
480
1.50
2.17
4.5
3.7
15.61
12.06
mg/mmol
0.22
46
319
6
15
4.05
2.05
12.0
2.6
31.00
28.20
%
—
6
15
63
452
1.49
2.02
4.2
3.3
100.54
210.91
mg/l
0.36
40
305
10
38
2.68
2.02
19.5
4.5
—
—
—
0
0
114
913
1.38
2.01
15.0
7.5
1.22
1.22
mmol/l
0.12
107
841
195
1701
1.36
1.98
3.4
2.8
37.35
36.97
u/l
0.03
187
1620
72
533
1.45
1.98
3.0
2.2
2.51
2.74
mg/l
0.58
65
438
7
21
3.38
1.97
1.0
1.1
—
—
—
0
0
5
11
4.60
1.95
1.0
1.6
1.54
2.16
mmol/l
—
5
11
78
588
1.43
1.94
5.8
2.7
0.06
0.31
e6/l
4.26
60
427
29
174
1.73
1.94
2.3
2.4
11553.30
1533.78
u/l
—
6
67
315
3013
2.00
1.90
24.6
14.5
260.47
257.62
e9/l
0.36
310
2922
14
66
2.17
1.84
6.9
2.6
—
—
—
0
0
48
332
1.52
1.84
3.3
2.8
2203.28
488.50
ng/l
0.42
32
228
17
87
2.01
1.83
2.4
2.2
—
—
—
0
0
315
3017
1.97
1.83
25.3
14.6
39.61
42.22
%
0.96
291
2856
5
12
4.21
1.83
5.6
2.7
13.85
19.90
ug/l
—
5
12
7
23
3.09
1.81
1.1
1.2
—
—
—
0
0
93
732
1.38
1.80
1.6
1.4
2.46
1.72
u/ml
0.24
27
185
315
3019
1.95
1.79
24.5
14.5
4.55
4.59
e12/l
0.69
309
2922
26
155
1.74
1.78
2.1
2.3
5.93
6.36
e9/l
0.09
26
142
15
74
2.08
1.78
1.1
1.1
—
—
—
0
0
97
771
1.37
1.76
2.3
2.1
—
—
—
0
0
315
3021
1.94
1.76
24.6
14.5
6.63
6.61
e9/l
0.07
309
2922
21
118
1.83
1.74
2.8
2.3
—
—
—
0
0
263
2428
1.41
1.73
23.5
12.8
335.29
334.11
g/l
1.43
263
2404
5
13
3.89
1.72
1.6
2.2
90.74
91.47
%
—
5
13
8
31
2.62
1.67
5.9
2.8
—
—
—
0
0
6
19
3.20
1.67
1.7
1.2
—
—
—
0
0
11
49
2.29
1.65
3.8
11.1
23.15
24.66
mmol/l
0.73
11
49
75
578
1.39
1.64
5.1
3.9
7.38
7.39
ph
0.77
11
98
88
697
1.36
1.63
1.5
1.7
96.31
93.75
pmol/l
0.20
46
376
5
14
3.61
1.62
2.0
3.8
2.70
3.06
nmol/l
—
5
14
42
296
1.48
1.49
4.8
2.2
27.94
29.77
s
2.16
42
287
168
1472
1.29
1.49
3.1
2.9
—
—
—
0
0
64
491
1.38
1.44
3.1
2.9
—
—
—
0
0
6
22
2.76
1.44
1.5
2.0
1.25
1.73
mmol/l
—
6
22
10
46
2.21
1.41
1.2
1.1
—
—
—
0
0
18
104
1.77
1.40
9.3
11.7
93.19
94.55
%
0.36
18
104
45
327
1.44
1.38
5.3
2.7
1.57
2.63
e6/l
0.76
25
174
24
152
1.62
1.36
5.8
4.9
63.56
70.64
ng/l
0.30
24
142
48
356
1.41
1.32
1.6
1.7
393.33
12698850.63
pmol/l
0.50
43
315
21
130
1.66
1.30
1.0
1.2
—
—
—
0
0
99
824
1.29
1.28
1.7
1.9
—
—
—
0
0
24
155
1.59
1.27
3.8
4.1
—
—
—
0
0
8
36
2.25
1.25
1.5
9.0
—
—
—
0
0
238
2204
1.29
1.25
4.2
3.4
5.69
5.65
mmol/l
0.24
228
2032
5
19
2.66
1.22
8.8
7.1
—
—
—
0
0
24
157
1.57
1.21
4.8
3.3
4.90
4.71
pmol/l
0.47
24
143
52
400
1.36
1.16
2.0
1.6
—
—
—
0
0
25
167
1.54
1.16
20.0
5.3
24.67
23.76
mmol/l
1.80
25
167
287
2736
1.38
1.15
13.3
8.9
—
—
—
0
0
0
36
0.00
1.14
0.0
3.8
—
18.35
—
0
36
37
270
1.42
1.13
1.3
1.2
—
—
—
0
0
8
40
2.02
1.13
1.1
1.4
—
—
—
0
0
31
219
1.46
1.12
20.8
4.6
5.51
4.82
kpa
0.75
31
214
81
668
1.28
1.12
3.0
2.1
—
—
—
0
0
5
21
2.40
1.09
1.0
1.5
—
—
—
0
0
7
34
2.08
1.03
6.4
2.5
5.14
4.92
kpa
—
7
34
7
34
2.08
1.03
6.4
2.5
9.41
8.99
kpa
—
7
34
15
92
1.66
0.99
1.0
1.1
—
—
—
0
0
7
36
1.96
0.97
3.1
3.1
2.46
3.65
e9/l
—
7
36
60
485
1.29
0.97
1.8
1.5
—
—
—
0
0
27
192
1.44
0.96
25.0
10.5
24.73
25.01
mmol/l
0.22
27
192
7
37
1.91
0.94
3.1
3.2
50.71
52.70
%
—
7
37
7
37
1.91
0.94
1.1
1.3
—
—
—
0
0
6
27
2.24
0.94
11.2
2.1
—
—
—
0
0
28
202
1.42
0.93
1.1
1.3
47.22
144.05
iu/ml
2.17
14
92
27
195
1.42
0.89
3.0
3.0
—
—
—
0
0
78
659
1.24
0.88
1.7
1.5
2.01
2.11
g/l
0.24
50
398
19
128
1.51
0.88
14.5
9.7
8.92
9.22
kpa
0.29
19
121
15
96
1.59
0.86
20.8
3.4
0.59
0.66
%
0.36
15
96
18
259
0.68
0.84
2.4
1.7
—
—
—
0
0
66
551
1.25
0.83
1.8
1.7
1.36
1.33
mmol/l
0.09
60
477
12
73
1.67
0.82
2.6
1.8
—
—
—
0
0
42
332
1.30
0.81
1.3
1.3
—
—
—
0
0
17
114
1.52
0.81
1.8
1.2
—
—
—
0
0
0
26
0.00
0.78
0.0
1.7
—
—
—
0
0
11
67
1.66
0.76
8.6
4.1
—
—
—
0
0
5
24
2.10
0.75
13.0
2.1
—
—
—
0
0
29
220
1.35
0.74
19.5
8.7
—
—
—
0
0
5
25
2.01
0.73
1.0
1.4
43.78
27.67
mu/l
—
5
25
7
39
1.81
0.73
2.3
2.6
—
—
—
0
0
231
2188
1.19
0.71
4.2
3.1
1.25
1.21
mmol/l
0.37
225
2057
5
26
1.94
0.71
2.4
1.4
13.16
12.74
%
—
5
26
33
259
1.30
0.69
1.7
1.6
—
—
—
0
0
239
2274
1.18
0.68
4.3
3.4
1.44
1.46
mmol/l
0.47
232
2145
20
145
1.40
0.67
1.3
1.5
254.15
323.34
mu/l
0.99
20
136
10
62
1.63
0.66
1.0
1.0
6.18
6.80
u/ml
—
5
34
7
44
1.60
0.65
1.9
2.4
—
—
—
0
0
13
87
1.51
0.64
36.2
8.6
1.24
1.18
mg/l
0.10
13
82
33
262
1.29
0.64
1.6
1.5
—
—
—
0
0
30
235
1.30
0.64
15.1
6.4
104.23
104.86
mmol/l
0.40
30
235
5
29
1.73
0.64
1.0
1.1
—
—
—
0
0
35
281
1.27
0.63
1.5
1.6
1139.97
1155.69
nmol/l
0.03
30
220
69
598
1.19
0.62
2.2
1.7
—
—
—
0
0
240
2292
1.17
0.62
4.4
3.5
4.69
4.66
mmol/l
0.22
233
2171
5
30
1.68
0.61
1.0
1.2
—
—
—
0
0
0
20
0.00
0.60
0.0
2.7
—
39765.25
—
0
20
11
73
1.52
0.57
23.0
6.6
—
—
—
0
0
22
283
0.76
0.56
2.2
1.8
—
—
—
0
0
9
61
1.49
0.54
1.0
1.3
—
—
—
0
0
22
281
0.77
0.53
2.2
1.7
—
—
—
0
0
22
281
0.77
0.53
2.2
1.7
—
—
—
0
0
241
2313
1.16
0.53
4.6
3.7
2.85
2.81
mmol/l
0.30
234
2176
22
279
0.77
0.51
2.2
1.7
—
—
—
0
0
10
67
1.51
0.50
1.4
1.2
—
—
—
0
0
77
688
1.16
0.49
3.1
3.3
2.34
2.37
mmol/l
1.13
71
632
15
199
0.74
0.48
1.5
1.3
—
—
—
0
0
16
210
0.75
0.48
2.4
1.9
—
—
—
0
0
23
182
1.28
0.48
19.9
8.0
1.54
1.43
mmol/l
0.15
23
177
18
138
1.32
0.46
3.3
3.9
1.22
1.23
mmol/l
0.29
13
118
20
157
1.29
0.44
1.3
1.7
—
—
—
0
0
55
484
1.16
0.43
2.0
1.8
—
—
—
0
0
5
32
1.57
0.42
1.0
3.0
8.86
7.06
mmol/l
—
5
32
5
32
1.57
0.42
1.2
1.2
—
—
—
0
0
0
17
0.00
0.41
0.0
1.1
—
—
—
0
0
5
34
1.48
0.40
1.0
2.9
1.90
1.47
mmol/l
—
5
34
8
61
1.32
0.40
1.1
1.3
—
65.56
—
0
9
15
192
0.77
0.39
4.2
2.2
—
—
—
0
0
9
69
1.31
0.37
1.8
2.0
0.39
0.66
ug/l
—
9
62
10
72
1.40
0.37
2.8
1.5
—
—
—
0
0
5
37
1.36
0.37
2.2
1.5
—
—
—
0
0
12
90
1.35
0.36
2.2
1.6
171.50
204.07
u/ml
—
6
46
6
41
1.47
0.36
3.2
2.3
—
—
—
0
0
6
41
1.47
0.36
1.0
1.0
—
—
—
0
0
6
42
1.44
0.35
1.2
1.1
—
—
—
0
0
22
181
1.23
0.35
1.7
1.4
—
—
—
0
0
21
253
0.82
0.34
1.2
1.2
—
—
—
0
0
85
918
0.90
0.33
2.8
2.3
—
—
—
0
0
11
83
1.34
0.32
1.0
1.1
1.32
3.20
u/ml
—
6
54
9
75
1.21
0.25
1.0
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
175.20
—
0
10
0
10
0.00
0.21
0.0
1.4
—
—
—
0
0
0
10
0.00
0.21
0.0
6.1
—
—
—
0
0
0
10
0.00
0.21
0.0
1.7
—
0.91
—
0
10
0
13
0.00
0.21
0.0
1.1
—
—
—
0
0
0
14
0.00
0.20
0.0
1.1
—
—
—
0
0
6
51
1.18
0.19
1.2
1.1
—
—
—
0
0
10
122
0.81
0.19
1.5
2.0
16.38
34.32
u/ml
—
10
117
18
157
1.15
0.18
14.3
8.4
—
—
—
0
0
22
196
1.13
0.17
3.2
2.8
0.23
0.22
g/l
0.32
22
183
6
76
0.79
0.16
1.3
3.5
—
—
—
0
0
11
93
1.19
0.14
1.0
1.3
0.40
3.61
u/ml
—
6
58
8
96
0.83
0.14
1.6
1.4
—
—
—
0
0
8
96
0.83
0.14
1.6
1.4
—
—
—
0
0
8
98
0.81
0.14
1.6
1.5
—
—
—
0
0
19
172
1.11
0.11
1.3
1.2
—
8.00
titre
—
0
5
5
44
1.14
0.10
1.2
1.1
—
—
—
0
0
18
164
1.10
0.10
1.4
1.3
—
—
—
0
0
10
87
1.15
0.09
2.2
2.9
—
—
—
0
0
7
68
1.03
0.08
1.0
1.3
—
—
—
0
0
27
255
1.06
0.07
1.6
1.9
—
—
—
0
0
9
84
1.07
0.07
1.7
1.7
—
—
—
0
0
10
107
0.93
0.02
10.4
2.5
20.20
22.00
s
—
10
101
78
786
0.99
0.00
1.4
1.6
—
—
—
0
0
12
118
1.02
0.00
2.6
2.3
—
—
—
0
0
23
234
0.98
0.00
2.3
2.7
0.74
0.76
ug/l
0.04
15
151
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
0.00
0.0
2.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
11.44
—
0
6
0
6
0.00
0.00
0.0
2.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.6
—
1.24
—
0
7
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.4
—
1.62
—
0
9
7
79
0.88
-0.00
3.9
1.1
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.5
—
—
—
0
0
22
220
1.00
-0.00
1.5
1.3
—
—
—
0
0
0
8
0.00
-0.00
0.0
2.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
2.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.1
—
—
—
0
0
5
55
0.91
-0.00
1.0
1.6
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0

Mortality – FinRegistry

Association

Association between endpoint M13_TRANSSYNOVITIS and mortality.

Females

Parameter HR [95% CI] p-value
M13_TRANSSYNOVITIS 1.188 [0.89, 1.59] 0.244
Birth year 0.993 [0.98, 1.0] 0.098

During the follow-up period (1.1.1998 — 31.12.2019), 53 out of 1551 females with M13_TRANSSYNOVITIS died.

Males

Parameter HR [95% CI] p-value
M13_TRANSSYNOVITIS 1.195 [0.91, 1.56] 0.196
Birth year 0.989 [0.98, 1.0] 0.024

During the follow-up period (1.1.1998 — 31.12.2019), 71 out of 2694 males with M13_TRANSSYNOVITIS died.

Mortality risk

Mortality risk for people of age

years, who have M13_TRANSSYNOVITIS.

N-year risk Females Males
1 0.096% 0.247%
5 0.579% 1.482%
10 1.456% 3.667%
15 2.989% 7.022%
20 5.127% 11.837%

Relationships between endpoints

Index endpoint: M13_TRANSSYNOVITIS – Transient synovitis

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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