Transient synovitis

M13_TRANSSYNOVITIS

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 M67.3
  • Cause of death: ICD-10 M67.3

2 out of 7 registries used, show all original rules.

328

4. Check minimum number of events

None

328

5. Include endpoints

None

328

6. Filter based on genotype QC (FinnGen only)

328

Control definitions (FinnGen only)

Control exclude
M13_SOFTTISSUE

Extra metadata

Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
M67
Name in latin
Synovitis transitoria

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 4739 1722 3013
Only index persons 3886 1464 2422
Unadjusted period prevalence (%)
Whole population 0.07 0.05 0.08
Only index persons 0.08 0.05 0.09
Median age at first event (years)
Whole population 6.89 8.17 6.11
Only index persons 8.02 10.50 6.51

-FinnGen-

Key figures

All Female Male
Number of individuals 328 191 137
Unadjusted period prevalence (%) 0.06 0.07 0.06
Median age at first event (years) 23.78 30.04 15.06

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
286
Matched controls
2859
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
M67.3
ICD-10 Finland
Transient synovitis
+∞
323.0
286
*
M67.4
ICD-10 Finland
Ganglion
31.6
31.2
41
15
M25.5
ICD-10 Finland
Pain in joint
4.9
28.3
112
330
NDM40
NOMESCO Finland
Discission of sheath of tendon of wrist or hand
+∞
20.0
19
*
M65.3
ICD-10 Finland
Trigger finger
27.6
17.2
23
9
NDM20
NOMESCO Finland
Excision of synovial ganglion of wrist or hand
180.1
16.7
17
*
M13.9
ICD-10 Finland
Arthritis, unspecified
7.8
16.3
38
55
NBG15
NOMESCO Finland
Acromioplastia, arthroscopic
40.5
15.6
19
5
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
4.8
13.9
48
115
NF1AE
NOMESCO Finland
Hip joint ultrasound examination
13.0
13.9
24
20
L04AX03
ATC
methotrexate; systemic (immunosuppressants)
5.3
13.2
41
87
TNX10
NOMESCO Finland
Arthrocentesis, unspecified region, unspecified region
6.2
12.9
35
63
M79.6
ICD-10 Finland
Pain in limb
3.0
12.8
86
355
NGA30
NOMESCO Finland
Exploration of knee joint, arthroscopic
10.0
12.8
25
27
NGF15
NOMESCO Finland
Total synovectomy of knee, arthroscopic
45.2
11.0
13
*
313
Kela drug reimbursment
Abatacept, adalimumab, anakinra, certolizumab pegol, etanercept, golimumab, infliximab, ixekizumab, sarilumab, secukinumab, tocilizumab and ustekinumab (rheumatoid diseases)
9.1
10.8
22
26
N06AA09
ATC
amitriptyline; systemic
6.4
10.7
28
48
NK4XE
NOMESCO Finland
Joint ultrasound examination not elsewhere classified
5.4
10.7
32
65
M65.9
ICD-10 Finland
Synovitis and tenosynovitis, unspecified
16.9
10.5
16
10
281
Kela drug reimbursment
Abatacept, adalimumab, anakinra, certolizumab pegol, etanercept, golimumab, infliximab, ixekizumab, sarilumab, secukinumab and tocilizumab
9.4
10.5
21
24
M01AH05
ATC
etoricoxib; oral
2.3
10.3
143
867
M19.0
ICD-10 Finland
Primary arthrosis of other joints
6.5
10.3
26
43
NGF00
NOMESCO Finland
Excision of plica of synovy of knee
12.8
10.0
17
14
NGF35
NOMESCO Finland
Plastic operation of joint cartilage of knee
10.6
9.7
18
18
M17.1
ICD-10 Finland
Other primary gonarthrosis
3.6
9.6
44
137
M75.1
ICD-10 Finland
Rotator cuff syndrome
3.7
9.3
41
123
M02AA07
ATC
piroxicam; topical
2.5
9.0
79
375
M05.8
ICD-10 Finland
Other seropositive rheumatoid arthritis
7.2
9.0
21
31
M75.4
ICD-10 Finland
Impingement syndrome of shoulder
11.2
8.9
16
15
N02AX02
ATC
tramadol; systemic, rectal
2.4
8.9
88
444
M65.8
ICD-10 Finland
Other synovitis and tenosynovitis
16.9
8.6
13
8
NGF25
NOMESCO Finland
Operation for osteochondritis of knee, arthroscopic
5.5
8.1
23
45
N02AJ06
ATC
codeine and paracetamol; systemic
2.2
7.9
92
500
A07EC01
ATC
sulfasalazine; oral, rectal
4.0
7.9
31
85
M01AC06
ATC
meloxicam; systemic, rectal
2.4
7.9
77
386
SPAT1153
SPAT
Removal of sutures
2.4
7.6
73
362
L88
ICPC
Rheumatoid/seropositive arthritis
6.8
7.5
18
28
P01BA02
ATC
hydroxychloroquine; oral
4.4
7.4
26
64
L04AA13
ATC
leflunomide; oral
11.3
7.4
13
12
G56.0
ICD-10 Finland
Carpal tunnel syndrome
3.5
7.2
32
98
N06AX21
ATC
duloxetine; oral
3.7
7.0
29
84
ZXA00
NOMESCO Finland
Right side
2.5
7.0
60
279
NF1AA
NOMESCO Finland
Hip X-ray examination
4.8
6.9
22
49
M01AE02
ATC
naproxen; oral, rectal
1.9
6.9
171
1242
NG1AA
NOMESCO Finland
Knee X-ray examination without contrast
3.3
6.6
32
105
M23.8
ICD-10 Finland
Other internal derangements of knee
6.0
6.6
17
30
M17.5
ICD-10 Finland
Other secondary gonarthrosis
14.7
6.4
10
7
M08.4
ICD-10 Finland
Pauciarticular juvenile arthritis
11.4
6.3
11
10
M01AH01
ATC
celecoxib; oral (coxibs)
3.0
6.3
36
132
NGF10
NOMESCO Finland
Total synovectomy of knee, open
+∞
6.3
6
*
M17.0
ICD-10 Finland
Primary gonarthrosis, bilateral
3.6
6.1
26
77
R01BA52
ATC
pseudoephedrine, combinations; oral
2.2
6.1
67
349
L15
ICPC
Knee symptom/complaint
2.2
6.0
63
320
M23.2
ICD-10 Finland
Derangement of meniscus due to old tear or injury
3.3
6.0
29
95
M01AX17
ATC
nimesulide; oral
2.6
6.0
42
175

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
189
1249
2.21
11.08
10.8
5.8
2.1
2.0
e9/l
0.30
174
1097
182
1190
2.19
10.90
10.9
5.9
0.6
0.6
e9/l
0.10
164
1020
185
1227
2.16
10.57
11.6
6.4
0.2
0.2
e9/l
0.02
170
1072
69
301
2.64
10.55
1.3
1.2
15.1
12.0
u/ml
0.08
24
117
181
1194
2.15
10.44
11.0
5.9
0.0
0.0
e9/l
0.12
165
1020
229
1670
2.23
10.04
6.2
3.4
9.7
8.9
mm/h
0.40
224
1536
178
1188
2.09
9.71
10.9
6.0
31.5
30.8
%
0.36
170
1126
176
1171
2.09
9.67
10.9
5.8
53.8
54.9
%
0.57
169
1110
170
1132
2.04
9.16
11.3
6.3
8.3
8.4
%
0.28
163
1071
168
1121
2.02
8.92
11.2
6.1
2.7
2.8
%
0.26
159
1048
12
16
7.75
8.46
2.3
1.5
—
—
—
0
0
162
1084
1.98
8.37
11.4
6.3
0.6
0.7
%
0.87
153
1018
195
1398
1.97
8.16
13.3
8.9
3.9
3.9
e9/l
0.20
179
1198
213
1576
2.00
8.12
5.2
3.7
—
—
—
0
0
124
763
2.01
8.09
9.9
5.9
—
—
—
0
0
57
270
2.34
7.18
1.4
1.3
511.1
390.0
titre
—
9
52
65
326
2.24
7.16
1.3
1.2
29.4
31.6
iu/ml
0.07
17
100
172
1225
1.85
6.91
6.3
4.8
6.5
6.4
mmol/l
0.09
155
1117
220
1697
1.90
6.81
7.7
6.4
80.0
82.1
u/l
0.21
211
1582
37
148
2.69
6.63
4.6
3.4
—
—
—
0
0
157
1113
1.79
6.19
4.9
3.1
0.0
0.0
estimate
0.00
25
214
81
468
1.97
6.09
4.4
3.7
—
—
—
0
0
157
1126
1.76
5.85
4.9
3.1
0.0
0.0
estimate
0.00
28
213
89
549
1.85
5.44
5.6
3.2
1.0
1.0
kg/l
0.07
15
79
153
1114
1.70
5.22
6.1
4.3
0.0
0.0
estimate
0.50
28
226
74
453
1.82
4.57
2.9
1.7
1.0
1.1
mg/l
0.20
57
332
289
2561
2.08
4.54
16.5
10.0
22.4
21.9
mg/l
0.07
222
1867
96
639
1.71
4.43
2.7
2.9
14.1
28.1
ng/l
2.02
57
355
90
592
1.72
4.32
4.9
3.4
0.0
0.0
estimate
0.80
28
214
79
501
1.76
4.32
4.7
3.0
—
—
—
0
0
49
268
1.97
4.25
2.7
2.1
—
—
—
0
0
115
812
1.64
4.21
7.0
4.8
36.8
37.0
g/l
0.15
110
765
30
137
2.31
4.10
1.6
1.5
—
—
—
0
0
236
1991
1.66
4.08
5.5
4.3
37.8
37.9
mmol/mol
0.06
225
1880
98
669
1.66
4.07
6.2
5.9
1.1
1.1
inr
0.05
27
222
68
425
1.76
3.88
3.4
2.5
4.5
6.2
e6/l
0.70
60
371
30
142
2.22
3.78
4.1
4.3
0.0
0.6
%
—
5
36
31
150
2.18
3.71
4.4
4.8
0.2
0.2
%
—
6
46
9
16
5.75
3.68
1.9
1.2
—
—
—
0
0
30
144
2.19
3.66
4.4
4.9
0.0
0.1
%
—
5
39
32
158
2.14
3.65
4.3
4.7
0.3
1.0
%
—
7
51
92
635
1.62
3.61
4.2
3.0
12.2
67.0
e6/l
2.63
71
476
40
216
1.97
3.60
1.4
1.4
—
—
—
0
0
22
93
2.46
3.57
6.0
9.1
—
—
—
0
0
92
637
1.62
3.56
3.4
2.8
—
—
—
0
0
152
1184
1.53
3.50
3.2
2.7
94.3
92.5
ug/l
0.04
147
1096
108
789
1.55
3.30
4.8
3.3
41.5
58.8
e6/l
0.23
75
515
24
111
2.25
3.21
1.0
1.1
—
—
—
0
0
131
1003
1.51
3.20
4.5
4.0
—
—
—
0
0
81
560
1.59
3.12
5.9
4.1
—
—
—
0
0
60
388
1.67
3.01
2.4
2.7
154.5
143.7
ug/g
0.07
44
308
20
88
2.36
3.00
7.2
14.7
—
—
—
0
0
257
2285
1.58
2.90
4.8
4.1
1.9
1.9
mu/l
0.01
251
2110
32
175
1.92
2.80
6.8
10.5
0.6
1.0
mmol/l
0.36
25
138
125
970
1.47
2.78
9.6
7.6
1.2
1.2
mmol/l
0.65
107
844
16
66
2.50
2.75
1.5
1.3
1.2
1.2
g/l
0.11
16
61
28
148
1.98
2.70
7.1
11.7
120.8
124.6
g/l
0.47
28
143
134
1064
1.44
2.60
6.2
5.8
11.9
11.8
umol/l
0.01
129
1004
291
2692
1.72
2.51
13.2
7.9
27.0
26.4
u/l
0.13
286
2600
80
579
1.50
2.48
3.8
2.7
—
—
—
0
0
82
599
1.49
2.43
2.4
2.4
—
—
—
0
0
64
444
1.55
2.41
4.4
2.5
9541.8
6727.6
umol/l
0.11
55
398
57
385
1.58
2.40
2.8
2.5
584.8
579.0
mosm/kgh2o
0.06
45
327
7
17
4.18
2.37
2.7
1.6
—
—
—
0
0
220
1936
1.41
2.26
4.2
3.6
14.4
14.6
pmol/l
0.85
207
1749
39
244
1.68
2.23
1.0
1.2
—
—
—
0
0
10
36
2.83
2.22
6.4
2.0
—
—
—
0
0
67
479
1.50
2.19
4.8
4.0
15.6
12.3
mg/mmol
0.20
46
318
83
620
1.45
2.18
11.8
6.7
—
—
—
0
0
113
894
1.40
2.17
10.7
7.1
1.2
1.2
mmol/l
0.13
106
820
9
30
3.06
2.16
19.1
3.1
74.2
68.0
%
—
9
30
94
722
1.42
2.13
1.6
1.4
2.5
1.7
u/ml
0.24
27
184
16
75
2.19
2.12
1.2
1.2
—
—
—
0
0
39
249
1.64
2.07
1.9
1.6
—
—
—
0
0
24
133
1.87
2.05
1.1
1.2
—
—
—
0
0
6
15
4.05
2.05
14.3
2.5
11.5
10.2
%
—
6
15
63
453
1.48
2.00
4.2
3.3
100.5
79.3
mg/l
0.21
40
301
139
1150
1.36
2.00
14.0
7.8
0.0
0.0
e9/l
0.32
114
926
29
173
1.74
1.97
2.3
2.4
11553.3
1521.3
u/l
—
6
68
5
11
4.60
1.95
5.6
1.9
13.9
19.7
ug/l
—
5
11
6
16
3.80
1.94
27.8
4.3
11.0
13.1
%
—
6
16
17
85
2.05
1.94
2.4
2.2
—
—
—
0
0
17
85
2.05
1.94
7.8
4.1
0.2
0.3
g/l
—
8
47
27
159
1.76
1.92
2.1
2.3
5.8
4.0
e9/l
1.32
27
137
48
330
1.53
1.89
3.3
2.8
2203.3
465.9
ng/l
0.43
32
227
313
2996
1.98
1.85
23.4
14.4
259.7
257.8
e9/l
0.23
308
2909
71
531
1.43
1.84
2.9
2.2
2.4
2.8
mg/l
0.95
64
437
5
12
4.21
1.83
1.2
1.3
—
—
—
0
0
5
12
4.21
1.83
1.0
1.6
1.5
2.1
mmol/l
—
5
12
76
577
1.41
1.82
4.0
2.8
0.1
0.3
e6/l
3.76
58
418
7
23
3.09
1.81
1.1
1.2
—
—
—
0
0
8
29
2.80
1.80
5.9
2.8
—
—
—
0
0
97
769
1.37
1.80
2.3
2.1
—
—
—
0
0
313
3002
1.93
1.74
23.4
14.3
4.6
4.6
e12/l
0.64
307
2909
5
13
3.89
1.72
1.6
2.2
90.7
91.4
%
—
5
13
21
119
1.82
1.70
2.8
2.4
—
—
—
0
0
313
3004
1.92
1.70
23.5
14.4
6.6
6.6
e9/l
0.03
308
2909
261
2413
1.40
1.67
22.1
12.7
335.3
334.1
g/l
1.40
261
2392
5
14
3.61
1.62
14.0
2.4
33.8
28.2
%
—
5
14
65
491
1.40
1.60
3.0
2.9
—
—
—
0
0
6
20
3.04
1.59
1.7
1.1
—
—
—
0
0
5
15
3.37
1.53
2.0
3.6
2.7
2.9
nmol/l
—
5
15
6
21
2.89
1.51
1.0
1.1
—
—
—
0
0
6
21
2.89
1.51
1.5
2.0
1.3
1.7
mmol/l
—
6
21
74
579
1.36
1.48
5.1
3.9
7.4
7.4
ph
0.84
11
99
7
28
2.53
1.46
3.4
1.5
—
—
—
0
0
7
28
2.53
1.46
3.4
1.5
—
—
—
0
0
7
28
2.53
1.46
3.4
1.5
—
—
—
0
0
7
28
2.53
1.46
3.4
1.5
—
—
—
0
0
13
66
2.01
1.45
7.6
2.7
—
—
—
0
0
5
16
3.16
1.44
1.8
1.3
—
—
—
0
0
25
158
1.63
1.42
3.8
4.1
—
—
—
0
0
10
46
2.21
1.41
1.2
1.1
—
—
—
0
0
87
703
1.32
1.40
1.5
1.7
95.9
94.4
pmol/l
0.11
47
381
167
1472
1.27
1.38
3.1
2.9
—
—
—
0
0
27
177
1.57
1.34
25.1
11.8
1.1
1.2
inr
—
10
36
21
129
1.67
1.33
1.0
1.2
—
—
—
0
0
5
18
2.80
1.29
8.8
7.4
—
—
—
0
0
48
359
1.39
1.26
1.6
1.7
393.3
12579056.3
pmol/l
0.50
43
318
8
36
2.25
1.25
1.5
8.8
—
—
—
0
0
8
36
2.25
1.25
22.0
3.4
—
—
—
0
0
99
829
1.28
1.21
1.6
1.9
—
—
—
0
0
40
293
1.42
1.19
4.7
2.2
27.8
29.8
s
2.42
40
284
18
110
1.67
1.18
1.8
1.2
—
—
—
0
0
37
268
1.43
1.17
1.3
1.2
—
—
—
0
0
0
36
0.00
1.14
0.0
3.8
—
18.3
—
0
36
33
236
1.44
1.12
14.3
4.8
1.8
1.6
mmol/l
0.17
28
186
237
2207
1.27
1.12
4.2
3.4
5.7
5.6
mmol/l
0.29
227
2036
24
161
1.53
1.10
4.8
3.3
4.9
4.7
pmol/l
0.45
24
147
5
21
2.40
1.09
1.0
1.5
—
—
—
0
0
13
74
1.79
1.08
2.7
1.8
—
—
—
0
0
33
238
1.43
1.08
14.5
4.8
—
—
—
0
0
51
397
1.34
1.06
2.0
1.6
—
—
—
0
0
270
2562
1.30
1.05
18.6
10.8
39.2
40.6
%
1.55
209
2078
7
34
2.08
1.03
6.4
2.5
5.1
5.0
kpa
—
7
34
7
34
2.08
1.03
6.4
2.5
9.4
9.0
kpa
—
7
34
16
99
1.65
1.02
6.6
10.5
92.7
94.6
%
0.50
16
99
7
35
2.02
1.00
3.1
3.1
2.5
3.6
e9/l
—
7
35
285
2730
1.34
0.98
12.9
8.8
—
—
—
0
0
5
23
2.19
0.98
1.0
1.3
43.8
28.5
mu/l
—
5
23
0
30
0.00
0.97
0.0
1.9
—
—
—
0
0
7
36
1.96
0.97
3.1
3.3
50.7
52.4
%
—
7
36
79
661
1.26
0.97
2.9
2.1
—
—
—
0
0
21
142
1.51
0.95
1.2
1.5
269.5
327.7
mu/l
0.73
21
133
78
654
1.25
0.94
1.7
1.5
2.0
2.1
g/l
0.27
50
395
27
193
1.43
0.94
3.0
3.0
—
—
—
0
0
6
27
2.24
0.94
11.3
2.3
—
—
—
0
0
28
202
1.42
0.93
1.1
1.3
47.2
147.0
iu/ml
2.26
14
91
29
211
1.41
0.92
15.3
4.4
5.5
4.8
kpa
0.77
29
206
34
257
1.36
0.87
1.6
1.5
—
—
—
0
0
58
475
1.27
0.85
1.6
1.5
—
—
—
0
0
25
180
1.42
0.85
16.7
8.3
24.8
25.1
mmol/l
0.29
25
180
18
259
0.68
0.84
2.4
1.8
—
—
—
0
0
22
155
1.45
0.83
4.9
5.1
64.8
71.2
ng/l
0.24
22
145
42
331
1.31
0.83
1.3
1.3
—
—
—
0
0
6
32
1.89
0.82
1.5
1.2
—
—
—
0
0
0
26
0.00
0.78
0.0
1.7
—
—
—
0
0
36
281
1.32
0.77
1.5
1.6
1113.6
1149.0
nmol/l
0.06
31
219
17
116
1.49
0.76
3.4
8.5
8.8
9.3
kpa
0.59
17
105
5
24
2.10
0.75
13.0
2.1
—
—
—
0
0
14
92
1.55
0.73
1.0
1.1
—
—
—
0
0
231
2187
1.19
0.73
4.2
3.2
1.3
1.2
mmol/l
0.35
225
2057
7
43
1.64
0.67
1.1
1.3
—
—
—
0
0
239
2278
1.18
0.65
4.3
3.4
1.4
1.5
mmol/l
0.37
232
2143
27
208
1.32
0.64
12.9
8.3
—
—
—
0
0
5
29
1.74
0.64
1.0
1.1
—
—
—
0
0
10
63
1.61
0.62
4.5
4.0
—
—
—
0
0
240
2294
1.17
0.61
4.4
3.5
4.7
4.7
mmol/l
0.29
233
2168
68
591
1.19
0.59
2.2
1.7
—
—
—
0
0
64
554
1.19
0.58
1.8
1.7
1.3
1.3
mmol/l
0.09
58
481
11
73
1.52
0.57
23.0
6.6
—
—
—
0
0
6
37
1.63
0.56
1.0
1.3
—
—
—
0
0
22
282
0.76
0.55
2.2
1.8
—
—
—
0
0
9
61
1.49
0.54
1.0
1.3
—
—
—
0
0
6
39
1.55
0.53
2.0
2.5
—
—
—
0
0
10
66
1.53
0.53
1.4
1.2
—
—
—
0
0
22
280
0.77
0.52
2.2
1.7
—
—
—
0
0
32
261
1.25
0.52
1.5
1.6
—
—
—
0
0
6
40
1.51
0.52
1.0
1.1
—
—
—
0
0
22
279
0.77
0.51
2.2
1.7
—
—
—
0
0
241
2317
1.15
0.51
4.6
3.7
2.8
2.8
mmol/l
0.30
234
2173
22
278
0.78
0.50
2.2
1.8
—
—
—
0
0
16
211
0.75
0.49
2.4
1.9
—
—
—
0
0
7
45
1.57
0.49
1.9
2.5
—
—
—
0
0
15
198
0.75
0.47
1.5
1.3
—
—
—
0
0
5
32
1.57
0.42
1.2
1.2
—
—
—
0
0
5
33
1.52
0.41
1.0
2.9
8.9
7.3
mmol/l
—
5
33
0
15
0.00
0.41
0.0
1.1
—
—
—
0
0
0
17
0.00
0.41
0.0
1.1
—
—
—
0
0
8
60
1.34
0.40
1.1
1.4
—
65.6
—
0
9
5
34
1.48
0.40
1.0
2.9
1.9
1.5
mmol/l
—
5
34
54
478
1.16
0.40
2.0
1.8
—
—
—
0
0
18
142
1.28
0.39
3.3
3.8
1.2
1.2
mmol/l
0.32
13
122
15
192
0.77
0.39
4.3
2.2
—
—
—
0
0
9
67
1.35
0.38
1.8
2.0
0.4
0.7
ug/l
—
9
60
75
683
1.13
0.37
3.2
3.3
2.3
2.4
mmol/l
1.46
69
626
5
37
1.36
0.37
2.6
2.2
—
—
—
0
0
9
70
1.29
0.37
2.3
1.5
—
—
—
0
0
6
42
1.44
0.35
1.2
1.1
—
—
—
0
0
21
254
0.81
0.35
1.2
1.2
—
—
—
0
0
19
156
1.23
0.31
1.3
1.6
—
—
—
0
0
11
84
1.32
0.30
36.4
8.3
1.2
1.2
mg/l
0.10
11
79
8
106
0.75
0.29
12.4
2.4
19.5
21.8
s
—
8
100
85
911
0.91
0.29
2.8
2.3
—
—
—
0
0
21
177
1.20
0.28
1.5
1.4
—
—
—
0
0
20
169
1.20
0.26
1.4
1.2
—
8.0
titre
—
0
5
9
74
1.22
0.25
1.0
1.1
—
—
—
0
0
11
87
1.27
0.24
1.6
1.6
158.8
203.5
u/ml
—
6
46
5
41
1.22
0.22
1.4
3.6
27.2
39.7
umol/l
—
5
36
5
42
1.19
0.21
1.2
1.0
—
—
—
0
0
0
11
0.00
0.21
0.0
1.1
—
5.8
—
0
11
0
10
0.00
0.21
0.0
1.2
—
—
—
0
0
0
10
0.00
0.21
0.0
1.4
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
0
10
0.00
0.21
0.0
1.9
—
—
—
0
0
11
89
1.24
0.21
1.0
1.2
0.4
2.2
u/ml
—
6
44
0
13
0.00
0.21
0.0
1.1
—
—
—
0
0
6
49
1.23
0.20
1.2
1.0
—
—
—
0
0
6
77
0.78
0.16
2.7
1.1
—
—
—
0
0
8
96
0.83
0.14
1.6
1.5
—
—
—
0
0
10
85
1.18
0.12
1.6
1.7
—
—
—
0
0
18
163
1.11
0.11
2.1
1.6
22.9
18.6
iu/l
0.22
18
139
16
145
1.11
0.09
3.8
7.3
—
—
—
0
0
7
68
1.03
0.08
1.0
1.3
—
—
—
0
0
20
214
0.93
0.07
1.6
1.3
—
—
—
0
0
11
122
0.90
0.07
1.5
2.0
15.4
34.6
u/ml
1.52
11
117
10
89
1.13
0.07
2.2
3.1
—
—
—
0
0
8
94
0.85
0.07
1.6
1.4
—
—
—
0
0
8
94
0.85
0.07
1.6
1.4
—
—
—
0
0
76
773
0.98
0.03
1.4
1.6
—
—
—
0
0
27
260
1.04
0.03
1.6
1.9
—
—
—
0
0
17
161
1.06
0.03
1.5
1.4
—
—
—
0
0
20
191
1.05
0.03
3.2
2.9
0.2
0.2
g/l
0.21
20
178
23
233
0.99
0.00
2.3
2.7
0.7
0.8
ug/l
0.04
15
148
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
0
8
0.00
0.00
0.0
1.4
—
—
—
0
0
0
8
0.00
0.00
0.0
2.0
—
—
—
0
0
0
5
0.00
0.00
0.0
2.4
—
4.2
—
0
5
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.6
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.6
—
144.0
—
0
5
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
11.4
—
0
6
7
75
0.93
0.00
1.3
2.7
—
—
—
0
0
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
0.00
0.0
2.0
—
—
—
0
0
0
9
0.00
0.00
0.0
4.9
—
—
—
0
0
0
6
0.00
0.00
0.0
2.2
—
—
—
0
0
0
7
0.00
0.00
0.0
1.6
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.6
—
1.2
—
0
7
12
120
1.00
0.00
2.6
2.3
—
—
—
0
0

Mortality – FinRegistry

Association

Association between endpoint M13_TRANSSYNOVITIS and mortality.

Females

Parameter HR [95% CI] p-value
M13_TRANSSYNOVITIS 1.188 [0.89, 1.59] 0.244
Birth year 0.993 [0.98, 1.0] 0.098

During the follow-up period (1.1.1998 — 31.12.2019), 53 out of 1551 females with M13_TRANSSYNOVITIS died.

Males

Parameter HR [95% CI] p-value
M13_TRANSSYNOVITIS 1.195 [0.91, 1.56] 0.196
Birth year 0.989 [0.98, 1.0] 0.024

During the follow-up period (1.1.1998 — 31.12.2019), 71 out of 2694 males with M13_TRANSSYNOVITIS died.

Mortality risk

Mortality risk for people of age

years, who have M13_TRANSSYNOVITIS.

N-year risk Females Males
1 0.096% 0.247%
5 0.579% 1.482%
10 1.456% 3.667%
15 2.989% 7.022%
20 5.127% 11.837%

Relationships between endpoints

Index endpoint: M13_TRANSSYNOVITIS – Transient synovitis

GWS hits: 1

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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