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R14

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Dysplastic lesion of unknown severity of the cervix uteri

PheWeb R13 (public) Endpoint Browser PheWeb

N14_CERVICAL_DYSPLASIA_NOS

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

519870

1. Apply sex-specific rule

only females

293145

2. Check conditions

None

293145

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — N87.9
  • Cause of death: ICD-10 — N87.9

2 out of 7 registries used, show all original rules.

417

4. Check minimum number of events

None

417

5. Include endpoints

None

417

6. Filter based on genotype QC (FinnGen only)

403

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

First used in FinnGen datafreeze
DF7

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 2302 2302 -
Only index persons 2267 2267 -
Unadjusted period prevalence (%)
Whole population 0.07 0.07 -
Only index persons 0.08 0.08 -
Median age at first event (years)
Whole population - 39.51 -
Only index persons - 39.34 -

-FinnGen-

Key figures

All Female Male
Number of individuals 403 403 -
Unadjusted period prevalence (%) 0.14 0.14 -
Median age at first event (years) 40.31 40.31 -

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
417
Matched controls
4170
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
N87.9
ICD-10 Finland
Dysplasia of cervix uteri, unspecified
+∞
307.7
417
*
ULA02
NOMESCO Finland
Kolposcopy
19.9
217.7
295
451
LDA20
NOMESCO Finland
Biopsy of vaginal cervix
16.0
188.0
233
305
LDC03
NOMESCO Finland
Conisation of cervix uteri using diathermy or laser
18.8
184.4
180
162
R87.6
ICD-10 Finland
Abnormal findings in specimens from female genital organs, abnormal cytological findings
12.0
150.3
247
451
LDA10
NOMESCO Finland
Curettage of cervix uteri
13.1
122.3
140
155
XLD00
NOMESCO Finland
Sytologyspecimen from mouth of uterus
9.4
120.9
239
519
N87.2
ICD-10 Finland
Severe cervical dysplasia, not elsewhere classified
14.0
96.6
99
91
8077/2-C53.9
ICD-O-3
Squamous intraepithelial neoplasia, high grade of cervix uteri
15.7
88.9
83
65
N87.0
ICD-10 Finland
Mild cervical dysplasia
11.4
74.6
86
93
N87.1
ICD-10 Finland
Moderate cervical dysplasia
9.9
52.6
65
76
A63.0
ICD-10 Finland
Anogenital (venereal) warts
5.2
23.9
53
114
LC2BE
NOMESCO Finland
Transvaginal ultrasound examination of uterus, parametria and lower abdomen
2.3
16.0
234
1475
LEB00
NOMESCO Finland
Biopsy of vagina
6.3
15.8
27
45
R87.5
ICD-10 Finland
Abnormal findings in specimens from female genital organs, abnormal microbiological findings
4.8
14.3
33
73
SPAT1193
SPAT
Pap smear
2.2
9.2
90
463
8140/2-C53.9
ICD-O-3
Adenocarcinoma in situ, NOS, of cervix uteri
28.2
8.5
11
*
D06.0
ICD-10 Finland
Carcinoma in situ: Endocervix
13.1
8.4
14
11
LCA06
NOMESCO Finland
Biopsy of endometrium
2.1
7.9
89
481
WX704
NOMESCO Finland
Intubation
2.5
7.9
50
212
WX702
NOMESCO Finland
Supraglottic ventilation device
2.9
7.8
37
135
R87.9
ICD-10 Finland
Abnormal findings in specimens from female genital organs, unspecified abnormal finding
18.8
7.6
11
6
X86
ICPC
Abnormal cervix smear
6.2
7.5
19
32
LCD31
NOMESCO Finland
Radical laparoscopic hysterectomy
81.5
7.4
8
*
WX725
NOMESCO Finland
Noninvasive ventilation
3.0
7.2
33
118
ZXC00
NOMESCO Finland
Use of diathermy
12.3
7.1
12
10
T81.0
ICD-10 Finland
Haemorrhage and haematoma complicating a procedure, not elsewhere classified
2.9
6.6
32
118
SPAT1324
SPAT
Screening procedure
1.8
6.6
139
920
LDB20
NOMESCO Finland
Electrocoagulation or laser therapy of cervix uteri
7.0
6.6
15
22
TPH04
NOMESCO Finland
Cathetrisation of vein
2.0
6.5
85
483
TLW99
NOMESCO Finland
Other minor surgical procedure in gynaecology
3.7
6.4
20
56
LFB00
NOMESCO Finland
Biopsy of vulva or perineum
3.5
6.2
21
62
LX1AE
NOMESCO Finland
Gynecological ultrasound examination as part of clinical examination
1.9
6.0
90
535

TimeCodeWAS

↥

TimeCodeWAS is a tool for exploring time-dependent associations between an endpoint and health codes (diagnoses, lab tests, procedures, etc.).

The TimeCodeWAS analysis is done in three steps:

  1. Build a matched case-control set for this endpoint. Each case is matched to 5–10 controls on sex and year of birth, and controls must be at risk at the same age as the case's age of onset. TimeCodeWAS allows for controls to be reused.
  2. Count cases and controls. For each health code, and for each time window: tally the counts into a 2×2 table. To be eligible in a time window, a case or control must have data coverage for at least 50% of that time window.
  3. Perform association tests. If all cells of the 2×2 table have N≥10, then a χ² test is performed, otherwise a Fisher's exact test is done. The corresponding p-value and confidence interval are reported below, along with the standard odds ratio when a χ² test is done, or Fisher's MLE odds ratio otherwise.

TimeCodeWAS currently uses the same default set of time windows for all the endpoints. Please reach out to us if you have suggestions for better time windows for some endpoints. The default time windows are: TimeCodeWAS time windows

Sort & Filter
Sort
Odds Ratio
among windows:
Filter
Code & OMOP
Cases and controls with code
in
Odds Ratio
in
OMOP Concept
Code (OMOP Vocabulary) [OMOP Concept ID]
OMOP Concept Class / OMOP Domain
Odds Ratio
TimeCodeWAS O.R. time legend
Cases and controls with code
TimeCodeWAS Cases and Controls percentages time legend
Obstetrics / Gynecology
16 (Medicare Specialty) [38004461]
Physician Specialty / Provider
3.2e-01 1.5e+00 2.1e+00 8.8e+00 2.7e+00 2.7e+00 1.6e+00
41.49%/34.03% 45.08%/14.84% 18.47%/2.61% 93.05%/0.17% 26.92%/2.47% 69.44%/13.80% 69.61%/31.59%
Outpatient Visit
OP (Visit) [9202]
Visit / Visit
2.9e-01 6.4e-01 7.7e-01 5.7e+00 8.6e-01 1.2e+00 7.2e-01
75.54%/69.83% 62.11%/46.40% 19.42%/10.02% 59.47%/0.48% 21.88%/10.56% 72.62%/45.58% 87.57%/77.35%
Laboratory Visit
OMOP4822461 (Visit) [32036]
Visit / Visit
6.5e-02 3.1e-01 6.3e-01 4.4e+00 5.8e-01 3.0e-01 8.2e-03
41.97%/40.38% 44.36%/36.93% 18.47%/10.72% 31.65%/0.55% 18.75%/11.47% 46.70%/39.38% 57.18%/56.98%
Severe cervical dysplasia, not elsewhere classified
N87.2 (ICD10) [45567869]
ICD10 code / Condition
1.4e+00 2.1e+00 — — 1.0e+50 4.2e+00 3.2e+00
2.40%/0.60% 2.88%/0.36% —/— —/— 2.16%/0.00% 14.67%/0.25% 10.77%/0.47%
Mild cervical dysplasia
N87.0 (ICD10) [45567868]
ICD10 code / Condition
1.7e+00 3.2e+00 1.0e+50 — — 4.2e+00 3.0e+00
2.40%/0.43% 4.56%/0.19% 1.20%/0.00% —/— —/— 9.05%/0.15% 8.56%/0.47%
Abnormal findings in specimens from female genital organs, abnormal cytological findings
R87.6 (ICD10) [45558487]
ICD10 code / Condition
1.9e+00 4.2e+00 — 1.0e+50 — 3.3e+00 2.5e+00
12.47%/2.04% 25.18%/0.50% —/— 3.84%/0.00% —/— 13.69%/0.59% 17.40%/1.74%
Kolposcopy
ULA02 (NCSPfi) [2001306679]
NCSPfi Level 3 / Procedure
1.8e+00 3.4e+00 — — — 4.2e+00 2.7e+00
11.99%/2.23% 19.18%/0.82% —/— —/— —/— 28.85%/0.62% 19.06%/1.57%
Biopsy of vaginal cervix
LDA20 (NCSPfi) [2001306656]
NCSPfi Level 3 / Procedure
1.7e+00 3.8e+00 — — — 3.9e+00 2.6e+00
7.91%/1.58% 13.43%/0.34% —/— —/— —/— 15.16%/0.34% 10.77%/0.88%
Supplier / Service Provider
OMOP5117446 (Visit) [33004]
Visit / Visit
-1.1e+00 -6.6e-01 — — — 3.9e+00 2.9e+00
11.99%/28.78% 4.80%/8.92% —/— —/— —/— 7.09%/0.15% 13.54%/0.83%

LabWAS

↥
OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
101
148
8.69
68.99
2.5
1.8
—
—
—
0
0
35
141
2.62
6.12
2.4
2.7
85.80
119.01
ng/l
0.30
30
131
128
881
1.65
5.04
3.6
3.2
1.02
1.02
kg/l
0.74
87
578
20
75
2.75
4.05
2.2
2.0
13.25
13.21
%
0.05
20
75
119
918
1.41
2.53
1.3
1.4
19.12
27.22
iu/ml
0.82
46
293
188
1574
1.35
2.41
3.6
3.2
0.00
0.04
estimate
1.63
42
364
37
225
1.71
2.30
3.6
3.0
2.58
2.05
mmol/l
0.50
31
195
136
1095
1.36
2.20
3.0
2.3
55.64
62.15
u/l
0.68
128
1027
134
1085
1.35
2.08
3.8
3.4
0.00
0.01
estimate
1.08
50
424
196
1686
1.31
1.97
2.6
2.0
—
—
—
0
0
234
2066
1.30
1.91
3.8
3.4
26.67
6.69
estimate
0.33
52
436
14
272
0.50
1.84
2.1
3.3
7.36
7.35
ph
—
8
192
24
395
0.58
1.81
2.0
1.8
—
—
—
0
0
7
23
3.08
1.80
1.9
2.3
44.20
50.22
%
—
7
12
6
154
0.38
1.79
1.3
1.3
—
—
—
0
0
107
857
1.33
1.76
1.3
1.3
9.07
14.36
u/ml
0.31
43
350
234
2080
1.28
1.76
3.7
3.4
0.00
0.02
estimate
1.08
49
420
40
269
1.54
1.71
1.4
1.4
—
—
—
0
0
25
150
1.71
1.67
3.0
2.3
1.98
5.34
ug/l
1.97
25
133
87
681
1.35
1.66
1.4
1.4
573.91
530.77
titre
0.07
23
156
35
234
1.54
1.55
3.7
3.0
7.37
7.39
ph
0.29
24
135
117
969
1.29
1.50
5.7
3.3
7.39
7.40
ph
0.35
87
678
228
2046
1.25
1.48
3.7
3.4
0.00
0.00
estimate
0.50
51
439
31
208
1.53
1.37
1.3
1.3
2.50
1.05
u/ml
—
5
11
24
153
1.60
1.32
1.8
1.7
—
—
—
0
0
13
70
1.88
1.25
1.0
1.1
—
—
—
0
0
25
165
1.55
1.20
1.2
1.2
—
—
—
0
0
12
64
1.90
1.19
1.2
1.8
5.77
5.62
mmol/24h
0.06
12
55
6
26
2.33
1.19
3.8
2.2
515.67
524.45
e6/l
—
6
20
18
112
1.63
1.10
4.6
4.7
—
—
—
0
0
357
3696
0.76
1.10
4.6
4.7
2.82
2.86
mmol/l
0.35
340
3539
5
21
2.40
1.09
1.2
1.2
—
—
—
0
0
177
1583
1.21
1.09
6.2
5.4
1.22
1.22
mmol/l
0.12
158
1374
52
403
1.33
1.09
2.1
2.5
6.56
5.34
umol/l
0.43
40
347
104
1211
0.81
1.06
1.9
2.0
—
—
—
0
0
33
239
1.41
1.04
1.1
1.1
—
—
—
0
0
78
644
1.26
1.03
1.7
1.6
432.88
35130868.74
pmol/l
1.05
69
575
17
261
0.64
1.03
1.2
1.6
—
—
—
0
0
158
1406
1.20
1.01
4.7
4.1
36.58
37.07
g/l
0.56
153
1341
17
258
0.64
0.98
1.2
1.6
—
—
—
0
0
17
258
0.64
0.98
1.2
1.6
—
—
—
0
0
17
257
0.65
0.97
1.2
1.6
—
—
—
0
0
0
32
0.00
0.95
0.0
1.3
—
69.28
—
0
32
76
632
1.25
0.95
2.5
2.3
71.34
85.91
ug/g
0.44
58
497
10
55
1.84
0.93
1.3
1.4
—
72.48
—
0
5
6
28
2.16
0.92
9.3
2.9
—
—
—
0
0
5
101
0.49
0.90
3.0
2.9
—
—
—
0
0
16
240
0.65
0.89
1.3
1.6
—
—
—
0
0
356
3670
0.80
0.87
4.2
4.3
4.80
4.84
mmol/l
0.37
347
3529
51
410
1.28
0.85
1.7
1.4
—
—
—
0
0
51
410
1.28
0.85
1.5
1.5
—
—
—
0
0
6
31
1.95
0.84
1.5
1.1
—
—
—
0
0
124
1097
1.19
0.83
5.9
5.8
—
—
—
0
0
148
1331
1.17
0.82
4.7
3.1
34.00
27.80
u/l
0.75
140
1272
196
1803
1.16
0.81
5.5
5.6
9.85
9.48
umol/l
0.33
185
1718
0
27
0.00
0.77
0.0
1.8
—
42.45
—
0
20
48
388
1.27
0.77
1.9
2.0
3582.53
7260.79
u/l
0.67
14
172
19
132
1.46
0.77
1.5
2.3
0.65
0.59
%
0.40
19
132
137
1231
1.17
0.76
6.2
7.4
1.07
1.08
inr
0.06
117
1019
7
38
1.86
0.74
1.1
1.1
—
—
—
0
0
7
38
1.86
0.74
1.3
1.7
—
—
—
0
0
356
3659
0.82
0.73
4.1
4.2
1.53
1.56
mmol/l
0.76
342
3500
9
56
1.62
0.73
1.8
2.1
—
—
—
0
0
11
68
1.63
0.72
1.0
1.1
—
—
—
0
0
121
1346
0.86
0.72
1.8
1.7
—
—
—
0
0
136
1228
1.16
0.71
2.9
2.9
0.00
0.17
estimate
0.63
40
363
9
145
0.61
0.70
1.1
1.2
—
—
—
0
0
7
42
1.68
0.68
1.1
1.3
—
—
—
0
0
7
42
1.68
0.68
1.1
1.3
—
—
—
0
0
7
42
1.68
0.68
1.1
1.3
—
—
—
0
0
7
42
1.68
0.68
1.1
1.3
—
—
—
0
0
7
120
0.58
0.68
1.4
1.3
—
—
—
0
0
7
120
0.58
0.68
1.3
1.7
—
—
—
0
0
7
43
1.64
0.67
1.3
1.4
—
—
—
0
0
285
2720
1.15
0.65
7.8
7.1
74.28
74.54
u/l
0.04
272
2590
55
463
1.22
0.64
1.2
1.3
127.53
150.44
u/ml
0.20
29
208
6
103
0.58
0.63
1.2
1.4
3.17
3.55
mmol/l
—
6
95
133
1456
0.87
0.63
1.7
1.9
97.12
98.88
pmol/l
0.20
79
791
5
30
1.67
0.61
1.4
2.5
4.12
4.01
mmol/l
—
5
30
5
30
1.67
0.61
1.4
2.5
1.22
1.19
mmol/l
—
5
30
5
30
1.67
0.61
1.4
2.5
104.00
106.00
mmol/l
—
5
30
81
711
1.17
0.61
1.4
1.5
—
—
—
0
0
0
20
0.00
0.60
0.0
2.0
—
—
—
0
0
0
20
0.00
0.60
0.0
1.0
—
—
—
0
0
0
22
0.00
0.59
0.0
1.2
—
7493.29
—
0
17
0
22
0.00
0.59
0.0
1.9
—
45.59
—
0
17
0
22
0.00
0.59
0.0
1.8
—
—
—
0
0
102
914
1.15
0.59
1.6
1.9
0.76
0.86
mg/l
0.32
82
703
61
524
1.19
0.59
2.8
2.2
15.53
14.33
umol/l
0.71
56
488
8
53
1.52
0.58
3.1
4.3
—
—
—
0
0
343
3329
1.17
0.58
16.6
14.5
13.36
13.38
%
0.10
338
3303
89
997
0.86
0.58
1.5
1.4
2.46
2.15
g/l
0.85
59
658
12
81
1.50
0.57
1.2
1.3
182.86
216.88
u/ml
—
7
52
32
257
1.27
0.57
4.7
7.1
7.43
7.41
ph
1.08
21
142
92
1027
0.87
0.57
4.2
3.0
6.89
7.56
mmol/l
0.83
86
889
324
3339
0.87
0.56
5.5
4.9
37.33
37.42
mmol/mol
0.07
308
3203
56
480
1.19
0.55
2.9
2.2
2.50
2.46
g/l
0.25
49
440
24
305
0.77
0.55
3.3
5.0
0.00
0.19
%
—
5
57
123
1122
1.14
0.55
2.9
2.4
—
—
—
0
0
9
61
1.49
0.54
2.7
1.9
9.11
8.09
kpa
—
9
61
20
153
1.32
0.51
1.5
2.0
—
—
—
0
0
25
312
0.79
0.51
3.2
4.5
0.42
1.14
%
—
6
76
25
198
1.28
0.50
5.5
7.2
—
—
—
0
0
55
632
0.85
0.50
2.2
2.2
2.41
2.42
mmol/l
0.52
49
571
24
300
0.79
0.49
3.3
4.3
0.67
0.96
%
—
6
69
28
343
0.80
0.49
1.6
1.8
0.33
0.06
estimate
—
9
84
30
245
1.24
0.48
1.1
1.1
—
195.71
—
0
7
196
1852
1.11
0.47
2.5
2.6
—
—
estimate
—
0
0
217
2063
1.11
0.46
6.1
6.2
0.18
0.18
e9/l
0.01
207
1842
18
138
1.32
0.46
5.5
2.8
24.28
24.33
mmol/l
0.02
18
138
7
49
1.44
0.46
1.0
1.1
—
—
—
0
0
7
49
1.44
0.46
1.6
2.0
67.43
59.79
%
—
7
49
60
528
1.16
0.45
2.9
3.2
150.94
318.55
ng/l
0.38
36
286
162
1719
0.91
0.43
9.2
9.1
0.00
0.00
e9/l
0.81
142
1409
0
16
0.00
0.41
0.0
2.7
—
—
—
0
0
0
16
0.00
0.41
0.0
2.2
—
1.58
—
0
16
69
619
1.14
0.41
2.0
1.5
—
—
—
0
0
0
17
0.00
0.40
0.0
2.6
—
519.73
—
0
11
5
34
1.48
0.40
1.0
1.1
92.00
119.50
pmol/l
—
5
34
110
1187
0.90
0.40
6.0
5.8
—
—
—
0
0
176
1667
1.10
0.39
3.6
3.0
6.28
6.22
ph
0.32
108
973
17
133
1.29
0.39
1.4
2.3
1.28
1.19
%
0.11
17
133
10
136
0.73
0.38
1.0
1.1
—
—
—
0
0
76
691
1.12
0.37
4.3
2.4
9.05
9.47
e6/l
0.04
64
623
50
442
1.15
0.37
2.2
1.9
—
—
—
0
0
9
71
1.27
0.36
1.8
1.2
—
—
—
0
0
23
276
0.82
0.35
1.6
1.6
—
—
—
0
0
48
425
1.15
0.35
3.3
2.3
25.33
23.11
%
0.61
43
394
379
3735
1.16
0.35
13.0
11.7
21.17
18.70
mg/l
0.72
303
2980
25
297
0.83
0.35
3.2
4.6
0.00
0.15
%
—
6
61
6
44
1.37
0.34
1.0
1.2
—
—
—
0
0
40
454
0.87
0.33
1.4
1.3
—
—
—
0
0
6
90
0.66
0.33
1.0
1.4
—
—
—
0
0
44
495
0.88
0.33
1.1
1.2
—
—
—
0
0
34
390
0.86
0.33
1.1
1.2
—
—
—
0
0
14
110
1.28
0.32
1.5
1.3
—
—
—
0
0
342
3481
0.90
0.31
4.1
4.1
5.60
5.65
mmol/l
0.38
322
3300
392
3878
1.18
0.30
10.5
10.2
26.36
23.94
u/l
0.56
385
3809
81
873
0.91
0.29
5.0
3.9
8.03
8.71
mg/mmol
0.07
53
517
125
1321
0.92
0.29
5.3
3.3
61.29
54.87
e6/l
0.09
88
836
9
117
0.76
0.28
1.0
1.1
—
—
—
0
0
9
117
0.76
0.28
1.0
1.1
—
—
—
0
0
23
268
0.85
0.27
1.6
1.5
—
—
—
0
0
5
72
0.69
0.26
1.0
1.9
5.24
5.87
pmol/l
—
5
72
23
266
0.86
0.25
1.5
1.5
1.21
1.28
mm
0.30
17
188
66
712
0.91
0.25
4.0
3.3
—
—
—
0
0
46
419
1.11
0.23
1.4
1.3
—
—
—
0
0
257
2507
1.07
0.23
5.0
4.1
3397.40
646.97
e6/l
—
5
30
17
200
0.84
0.23
1.1
1.1
1.64
1.61
g/l
0.20
17
200
7
93
0.75
0.22
1.9
3.6
59.14
59.23
%
—
7
93
186
1799
1.06
0.22
6.5
5.9
8.10
8.27
%
0.41
176
1701
23
262
0.87
0.22
1.7
1.3
269.49
249.26
miu/ml
—
10
136
5
42
1.19
0.21
1.8
1.4
17.20
22.19
ng/l
—
5
42
8
104
0.76
0.21
12.9
5.6
—
—
—
0
0
0
13
0.00
0.21
0.0
1.7
—
153.62
—
0
13
22
250
0.87
0.20
1.0
1.1
—
—
—
0
0
47
433
1.10
0.20
1.8
1.6
1244.78
1185.61
nmol/l
0.21
41
337
31
279
1.12
0.20
2.1
1.7
—
—
—
0
0
361
3649
0.92
0.20
5.7
6.0
1.69
1.73
mu/l
0.39
346
3509
34
308
1.11
0.20
1.2
1.2
—
—
—
0
0
201
1955
1.05
0.19
4.4
4.1
6.30
6.28
mmol/l
0.06
182
1787
53
493
1.09
0.19
3.7
2.4
4.45
4.70
e6/l
0.07
31
209
76
803
0.93
0.18
2.6
2.2
300.31
296.82
umol/l
0.13
68
748
13
153
0.84
0.18
2.1
2.2
—
—
—
0
0
7
59
1.19
0.18
1.9
4.2
41.61
22.49
mg/l
—
7
50
7
59
1.19
0.18
1.7
4.2
59.21
31.48
mg/l
—
7
51
7
59
1.19
0.18
1.4
2.1
—
—
—
0
0
116
1207
0.95
0.17
2.5
3.1
2.34
2.35
mmol/l
0.70
111
1135
18
205
0.87
0.17
1.1
1.1
0.82
0.88
g/l
0.60
18
205
14
120
1.17
0.16
1.6
1.7
—
11.42
—
0
5
44
409
1.08
0.16
1.8
1.4
—
—
—
0
0
10
83
1.21
0.15
1.2
1.2
—
—
—
0
0
184
1795
1.04
0.15
6.5
5.9
0.65
0.70
%
0.69
174
1687
9
81
1.11
0.15
1.6
1.1
—
—
—
0
0
360
3631
0.94
0.14
13.5
11.8
139.48
139.65
mmol/l
0.58
355
3560
224
2283
0.96
0.14
3.4
3.3
74.21
65.49
ug/l
0.57
219
2182
279
2749
1.05
0.14
3.0
3.1
40.54
33.79
u/l
0.79
268
2662
112
1082
1.05
0.14
2.0
1.8
—
—
—
0
0
184
1799
1.04
0.13
6.2
5.8
2.81
2.76
%
0.12
174
1697
329
3255
1.05
0.13
5.0
5.0
14.18
14.33
pmol/l
0.67
313
3094
216
2201
0.96
0.13
8.1
8.8
3.87
3.91
e9/l
0.13
199
1941
207
2029
1.04
0.13
6.2
5.9
1.96
1.99
e9/l
0.13
200
1828
9
106
0.85
0.13
6.0
4.0
37.03
36.95
°c
—
9
106
30
324
0.92
0.13
4.1
2.3
58.32
31.89
u/l
0.64
22
275
83
863
0.95
0.12
4.5
3.3
49.42
46.40
mg/l
0.05
57
534
361
3637
0.94
0.12
13.6
11.8
3.92
3.90
mmol/l
0.55
356
3550
118
1146
1.04
0.12
1.3
1.3
0.66
2.05
u/ml
1.73
33
334
22
201
1.10
0.11
2.7
2.1
10.06
7.33
iu/ml
—
9
49
93
961
0.96
0.11
2.3
2.1
2.48
2.58
mg/l
0.25
84
838
10
115
0.87
0.10
1.3
1.3
—
—
—
0
0
27
251
1.08
0.10
3.4
4.3
17.66
7.48
ug/l
0.45
20
195
36
339
1.07
0.10
3.4
3.4
—
—
—
0
0
93
904
1.04
0.09
1.5
1.5
20.91
21.38
nmol/l
0.12
81
798
26
243
1.07
0.09
1.3
1.2
—
—
—
0
0
90
877
1.03
0.08
1.7
1.8
—
—
—
0
0
53
511
1.04
0.07
1.3
1.2
—
—
—
0
0
114
1117
1.03
0.07
2.9
3.0
88.90
96.35
ng/l
0.03
46
552
7
85
0.82
0.07
1.3
1.2
—
—
—
0
0
21
197
1.07
0.06
13.5
7.0
9.20
7.22
mmol/l
0.65
21
190
107
1050
1.03
0.06
3.9
4.2
—
—
—
0
0
176
1780
0.98
0.05
2.5
2.5
72.75
76.15
nmol/l
0.90
165
1674
14
150
0.93
0.04
5.7
8.3
90.93
94.18
%
0.61
14
150
188
1863
1.02
0.04
6.2
5.8
30.40
29.61
%
0.55
180
1779
200
1983
1.02
0.04
6.0
5.9
0.04
0.04
e9/l
0.36
185
1743
11
101
1.09
0.04
3.5
3.3
353.83
174.43
mg/l
—
6
37
389
3901
0.96
0.04
11.6
10.7
—
—
—
0
0
141
1394
1.02
0.04
7.1
4.8
1.22
1.22
mmol/l
0.22
134
1304
19
180
1.06
0.04
1.2
1.6
0.31
0.28
mg/l
0.11
12
76
16
169
0.94
0.03
1.9
2.2
2.06
4.48
iu/l
—
5
67
89
902
0.98
0.03
4.7
2.6
0.34
0.35
e6/l
0.01
66
624
344
3451
0.98
0.02
3.4
3.6
1.20
1.19
mmol/l
0.13
329
3282
45
460
0.98
0.02
1.2
1.7
3.16
3.36
mmol/l
0.64
27
324
172
1729
0.99
0.01
2.5
2.6
—
—
—
0
0
60
608
0.98
0.01
3.4
2.5
519.54
509.61
mosm/kgh2o
0.15
50
533
199
1981
1.01
0.01
6.0
5.8
0.52
0.52
e9/l
0.15
185
1746
40
393
1.02
0.01
2.1
2.0
375.25
378.54
nmol/l
0.03
40
373
125
1243
1.01
0.01
2.3
2.1
—
—
—
0
0
56
554
1.01
0.00
1.6
1.6
998.87
1009.00
mu/l
0.03
47
459
31
312
0.99
0.00
1.6
2.1
6.35
6.16
ph
0.69
24
198
104
1042
1.00
0.00
5.0
2.7
20.62
88.05
e6/l
1.40
80
759
154
1542
1.00
0.00
1.9
1.8
1.30
1.34
mmol/l
0.31
140
1373
29
291
1.00
0.00
1.3
1.3
—
30.53
—
0
21
20
205
0.97
0.00
1.4
1.3
—
—
—
0
0
0
6
0.00
0.00
0.0
2.5
—
6.72
—
0
6
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
2.0
—
—
—
0
0
5
51
0.98
0.00
1.2
1.7
—
—
—
0
0
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
0
6
0.00
0.00
0.0
1.3
—
41.12
—
0
6
0
7
0.00
0.00
0.0
1.0
—
0.03
—
0
7
0
9
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
9
0.00
-0.00
0.0
3.6
—
16.22
—
0
9
0
5
0.00
-0.00
0.0
1.2
—
15.93
—
0
5
0
5
0.00
-0.00
0.0
1.6
—
—
—
0
0
5
59
0.85
-0.00
1.4
1.4
18.69
35.03
nmol/l
—
5
49
5
57
0.88
-0.00
1.2
1.5
—
—
—
0
0
5
49
1.02
-0.00
1.0
2.1
—
—
—
0
0
0
9
0.00
-0.00
0.0
2.0
—
—
—
0
0
183
1830
1.00
-0.00
6.1
5.7
55.99
56.50
%
0.25
177
1759
7
73
0.96
-0.00
1.9
3.6
4.00
4.49
e9/l
—
7
73
7
73
0.96
-0.00
2.1
2.2
—
—
—
0
0
0
9
0.00
-0.00
0.0
2.6
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.1
—
132.66
—
0
9
6
60
1.00
-0.00
1.0
1.2
—
—
—
0
0
5
49
1.02
-0.00
1.8
1.6
2.52
82.54
u/ml
—
5
49
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0

Mortality – FinRegistry

↥

Association

Association between endpoint N14_CERVICAL_DYSPLASIA_NOS and mortality.

Females

Parameter HR [95% CI] p-value
N14_CERVICAL_DYSPLASIA_NOS 1.369 [1.07, 1.75] 0.012
Birth year 0.993 [0.98, 1.0] 0.115

During the follow-up period (1.1.1998 — 31.12.2019), 106 out of 1959 females with N14_CERVICAL_DYSPLASIA_NOS died.

Males

No data

Mortality risk

Mortality risk for people of age

years, who have N14_CERVICAL_DYSPLASIA_NOS.

N-year risk Females Males
1 0.13% No data
5 0.761% No data
10 1.873% No data
15 3.773% No data
20 6.533% No data

Relationships between endpoints

↥

Index endpoint: N14_CERVICAL_DYSPLASIA_NOS – Dysplastic lesion of unknown severity of the cervix uteri

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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