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Other congenital malformations, not elsewhere classified

EFO Endpoint Browser PheWeb

Q17_OTHER_CONGEN_MALFO_NOT_ELSEW_CLASSIFIED

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

519972

1. Apply sex-specific rule

None

519972

2. Check conditions

None

519972

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — Q89
  • Cause of death: ICD-10 — Q89

2 out of 7 registries used, show all original rules.

322

4. Check minimum number of events

None

322

5. Include endpoints

None

322

6. Filter based on genotype QC (FinnGen only)

307

Control definitions (FinnGen only)

Control exclude
Q17_OTHER_CONGEN_MALFO

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF4
Parent code in ICD-10
Q8
Name in latin
Aliae malformationes congenitae non alibi classificatae

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 3086 1558 1514
Only index persons 2386 1228 1158
Unadjusted period prevalence (%)
Whole population 0.04 0.04 0.04
Only index persons 0.04 0.05 0.04
Median age at first event (years)
Whole population 10.81 12.42 8.94
Only index persons 16.53 18.98 13.93

-FinnGen-

Key figures

All Female Male
Number of individuals 307 189 118
Unadjusted period prevalence (%) 0.06 0.07 0.05
Median age at first event (years) 34.82 35.09 34.38

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
322
Matched controls
3220
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
Q89.23
ICD-10 Finland
Cyst of the ductus thyreoglossus
+∞
119.4
107
*
Q89.7
ICD-10 Finland
Multiple congenital malformations, not elsewhere classified
+∞
72.7
67
*
ENB50
NOMESCO Finland
Excision of cyst or fistula of thyroglossic duct
384.6
63.8
62
*
Q89.9
ICD-10 Finland
Congenital malformation, unspecified
+∞
36.1
34
*
R22.1
ICD-10 Finland
Localized swelling, mass and lump, neck
10.8
31.8
36
37
ZXD10
NOMESCO Finland
Scheduled procedure
3.7
30.3
174
771
Z31.5
ICD-10 Finland
Genetic counselling
5.8
29.8
61
124
Q89.34
ICD-10 Finland
Cartagena syndrome (immotile cilia)
+∞
29.6
28
*
WX408
NOMESCO Finland
General anesthesy, balanced
3.8
29.2
138
535
ZXE10
NOMESCO Finland
More than one and less than three hours
3.5
27.2
159
701
Q89.30
ICD-10 Finland
Situs inversus with dextrocardia
+∞
24.3
23
*
EP1AE
NOMESCO Finland
Neck ultrasound examination
6.1
22.6
42
77
R2130
NOMESCO Finland
Counselling and guidance which enhance independent living
4.4
21.4
62
167
Q89.88
ICD-10 Finland
Other specified congenital malformations
+∞
21.1
20
*
Z2446
NOMESCO Finland
Social worker
4.0
20.0
66
195
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
4.9
19.7
48
112
Q89.22
ICD-10 Finland
Permanent ductus thyreoglossus
+∞
18.9
18
*
Q87.88
ICD-10 Finland
Other specified congenital malformation syndromes, not elsewhere classified
+∞
17.9
17
*
Q18.0
ICD-10 Finland
Sinus, fistula and cyst of branchial cleft
37.3
16.9
21
6
Z3226
NOMESCO Finland
Physiotherapist
3.0
16.7
93
381
ZXE00
NOMESCO Finland
One hour or less
2.7
16.6
161
878
J47
ICD-10 Finland
Bronchiectasis
26.1
16.2
22
9
WX402
NOMESCO Finland
General anaesthesia
2.9
16.2
104
459
R62.0
ICD-10 Finland
Delayed milestone
6.0
15.9
29
52
Z2221
NOMESCO Finland
Medical doctor
2.7
15.3
119
577
R4110
NOMESCO Finland
Physiotherapy
2.7
14.9
112
533
XF400
NOMESCO Finland
ECG with 12 standard connections
3.2
14.9
71
264
TPH07
NOMESCO Finland
Cathetrisation of artery
3.8
14.7
50
150
XA800
NOMESCO Finland
Neuropsychological investigation
4.2
14.4
41
108
Q18.8
ICD-10 Finland
Other specified congenital malformations of face and neck
44.6
14.2
17
*
Z3229
NOMESCO Finland
Other healthcare associate professional
3.7
13.9
49
150
Z2445
NOMESCO Finland
Psychologist
3.6
13.8
50
156
R1100
NOMESCO Finland
General evaluation of the need for rehabilitation
6.3
13.2
23
39
UDC00
NOMESCO Finland
Ear microscopy
3.8
13.2
43
125
Q24.0
ICD-10 Finland
Dextrocardia
135.1
12.5
13
*
WX404
NOMESCO Finland
Intravenous generell anesthesy
2.5
12.4
98
473
XF404
NOMESCO Finland
Ambulatory ECG
4.0
12.3
37
101
AA5HE
NOMESCO Finland
Brain ultrasound examination in a child
5.8
11.8
22
40
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
3.0
11.4
55
204
FXA00
NOMESCO Finland
Total cardiopulmonary bypass in normothermia or moderate hypothermia at concurrent surgical procedure
5.1
11.1
24
50
UKC02
NOMESCO Finland
Cystoscopy
3.4
11.1
43
140
R4130
NOMESCO Finland
Speech therapy
5.2
10.9
23
47
Z03.5
ICD-10 Finland
Observation for other suspected cardiovascular diseases
3.4
10.9
42
136
ZXE20
NOMESCO Finland
More than three and less than five hours
3.0
10.8
55
210
TPH04
NOMESCO Finland
Cathetrisation of vein
2.6
10.8
75
337
ZXA05
NOMESCO Finland
Left side
2.6
10.7
74
332
UDQ12
NOMESCO Finland
Flexible laryngoscopy
4.4
10.6
27
65
R1230
NOMESCO Finland
Neuropsychological evaluation of need and possibilities to rehabilitation
5.4
10.5
21
41
Z3231
NOMESCO Finland
Registered nurse
2.3
10.5
116
643
Z01.1
ICD-10 Finland
Examination of ears and hearing
2.6
10.4
69
303
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.2
10.3
131
767
ZXE05
NOMESCO Finland
Procedure duration 40 to 49 minutes
3.6
10.0
35
106
ZXA00
NOMESCO Finland
Right side
2.5
9.9
75
351
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
3.0
9.8
47
174
F79.0
ICD-10 Finland
Unspecified mental retardation, with the statement of no, or minimal, impairment of behaviour
10.5
9.6
18
18
ZXD20
NOMESCO Finland
Day surgery
2.8
9.6
52
205
H65.3
ICD-10 Finland
Chronic mucoid otitis media
3.5
9.6
35
109
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
2.6
9.6
65
288
J45.1
ICD-10 Finland
Nonallergic asthma
3.2
9.5
41
142
J01MA14
ATC
moxifloxacin; systemic
3.5
9.5
34
105
R4120
NOMESCO Finland
Occupational therapy
3.6
9.5
33
100
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
2.7
9.4
57
239
ZXD30
NOMESCO Finland
Difficulties in perfomrming procedure
3.8
9.3
29
81
J45.9
ICD-10 Finland
Asthma, unspecified
2.4
9.2
74
355
ZXE04
NOMESCO Finland
Procedure duration 30 to 39 minutes
3.3
9.1
36
118
FM2CE, ,
NOMESCO Finland
4.6
9.0
22
51
RL140, ,
NOMESCO Finland
13.0
9.0
15
12
Q21.08
ICD-10 Finland
Other specifed ventricular septal defect
9.4
8.6
17
19
NK6MA
NOMESCO Finland
Measurement of bone age from hand and elbow using X-ray
3.9
8.6
26
71
F83
ICD-10 Finland
Mixed specific developmental disorders
4.5
8.5
21
49
GD1DD
NOMESCO Finland
High resolution CT examination of lungs
4.5
8.5
21
49
Q53.1
ICD-10 Finland
Undescended testicle, unilateral
20.7
8.5
12
6
F82
ICD-10 Finland
Specific developmental disorder of motor function
7.0
8.5
20
30
FM1BE
NOMESCO Finland
Cardiac ultrasound examination through oesophagus
3.6
8.4
29
87
XF600
NOMESCO Finland
Bloodpressure measurement
3.1
8.4
37
130
7593A
ICD-9 Finland
Other and unspecified congenital anomalies, Situs inversus
+∞
8.4
8
*
Q89.21
ICD-10 Finland
Congenital malformation of the thyroid gland
+∞
8.4
8
*
Q89.00
ICD-10 Finland
Asplenia (congenital)
+∞
8.4
8
*
Q89.32
ICD-10 Finland
Abdominal situs inversus
+∞
8.4
8
*
R03BB04
ATC
tiotropium bromide; inhalant
3.5
8.3
29
88
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
2.4
8.2
61
282
Q21.00
ICD-10 Finland
Multiple ventricular septal defect
17.7
8.1
12
7
WX892
NOMESCO Finland
Monitored bed care
3.1
8.0
35
122
ZXE30
NOMESCO Finland
More than five and less than seven hours
3.8
8.0
25
70
KFH00
NOMESCO Finland
Operation for undescended or ectopic testis
13.5
7.9
13
10
LC2AE
NOMESCO Finland
Ultrasound examination of uterus and parametria
2.7
7.8
45
183
Q21.10
ICD-10 Finland
Persistent ostium secundum
7.7
7.8
17
23
NE1AA
NOMESCO Finland
Pelvis X-ray examination
3.7
7.6
24
68
XX9AW
NOMESCO Finland
Production of copy from X-ray picture
4.2
7.5
20
50
203
Kela drug reimbursment
Chronic asthma and similar chronic obstructive pulmonary diseases
2.2
7.4
70
357
J20.9
ICD-10 Finland
Acute bronchitis, unspecified
2.3
7.4
67
336
R03BA01
ATC
beclometasone; inhalant
2.6
7.3
45
189
Q89.20
ICD-10 Finland
Congenital malformation of pituitary gland
+∞
7.3
7
*
EBA15
NOMESCO Finland
Extraction of multiple teeth
4.1
7.3
20
51
ZXE11
NOMESCO Finland
Procedure duration 60 to 89 minutes
2.6
7.1
45
192
H52.2
ICD-10 Finland
Astigmatism
4.0
7.1
20
52
Z01.8
ICD-10 Finland
Other specified special examinations
2.1
7.1
74
393
DCA20
NOMESCO Finland
Insertion of ventilating tube through tympanic membrane
2.8
7.1
38
149
T86
ICPC
Hypothyroidism/myxoedema
4.3
6.9
18
44
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
3.0
6.9
31
110
RL130, ,
NOMESCO Finland
8.6
6.9
14
17
WYA30
NOMESCO Finland
Treatment of a patient needing special arrangements
2.5
6.8
44
189
ZXE06
NOMESCO Finland
Procedure duration 50 to 59 minutes
2.8
6.7
34
129
R03BA02
ATC
budesonide; inhalant
2.1
6.7
68
357
4730A
ICD-9 Finland
Chronic sinusitis, Maxillary
7.6
6.5
14
19
NA7EA
NOMESCO Finland
Scoliosis X-ray examination
7.6
6.5
14
19
J18.9
ICD-10 Finland
Pneumonia, unspecified
2.1
6.5
69
369
M41.5
ICD-10 Finland
Other secondary scoliosis
71.2
6.4
7
*
TJD20
NOMESCO Finland
Change of gastrostomy tube
14.7
6.4
10
7
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.0
6.4
76
422
UGC12
NOMESCO Finland
Flexible bronchoscopy
3.6
6.4
21
61
R31
ICD-10 Finland
Unspecified haematuria
3.0
6.4
28
98
WX704
NOMESCO Finland
Intubation
2.9
6.3
30
110
Q89.38
ICD-10 Finland
Another site inversus
+∞
6.3
6
*
Q25.41
ICD-10 Finland
Persistent right-sided aortic arch
+∞
6.3
6
*
R03AK06
ATC
salmeterol and fluticasone; inhalant
2.4
6.3
47
217
ZXA10
NOMESCO Finland
Bilateral
2.1
6.2
64
338
F70.0
ICD-10 Finland
Mild mental retardation, With the statement of no, or minimal, impairment of behaviour
10.3
6.1
11
11

LabWAS

↥
OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
24
20
12.87
13.83
8.4
3.0
—
—
—
0
0
79
366
2.54
10.71
4.6
3.3
578.81
396.77
ng/l
0.26
44
235
64
286
2.54
9.26
2.5
2.2
—
—
—
0
0
93
501
2.20
8.77
5.4
4.4
—
—
—
0
0
66
308
2.44
8.68
13.1
10.5
—
—
—
0
0
65
302
2.44
8.63
2.7
1.7
—
—
—
0
0
194
1379
2.02
8.55
8.5
7.0
0.62
0.55
e9/l
2.14
175
1196
194
1381
2.02
8.49
8.5
7.0
0.04
0.04
e9/l
0.77
175
1196
197
1426
1.98
8.03
9.2
7.6
0.20
0.19
e9/l
0.10
177
1259
180
1268
1.95
7.90
8.7
7.3
0.66
0.67
%
0.14
172
1205
185
1324
1.93
7.65
8.6
7.4
8.66
8.21
%
1.20
179
1269
184
1317
1.93
7.58
8.6
7.1
2.89
2.97
%
0.16
178
1258
46
193
2.61
7.52
8.2
12.2
0.79
0.65
mmol/l
0.08
37
159
183
1313
1.91
7.43
8.4
7.3
—
—
—
0
0
195
1443
1.89
7.04
8.6
7.0
2.11
2.17
e9/l
0.20
177
1288
153
1053
1.86
6.91
15.5
8.8
1.21
1.22
mmol/l
0.92
146
980
65
331
2.21
6.90
9.4
8.1
1.87
1.47
mmol/l
0.51
58
261
188
1384
1.86
6.81
8.5
7.1
31.68
31.82
%
0.06
181
1332
20
54
3.88
6.75
1.7
1.6
0.84
0.65
g/l
0.20
14
46
130
857
1.87
6.67
6.8
5.8
37.09
37.01
g/l
0.06
124
819
116
738
1.89
6.64
9.4
7.9
—
—
—
0
0
114
722
1.90
6.61
2.9
2.5
—
—
—
0
0
57
281
2.25
6.53
3.8
2.9
19.43
23.29
%
1.63
50
254
74
406
2.07
6.47
4.7
3.2
3.00
2.70
e6/l
0.07
40
224
135
909
1.84
6.41
6.6
4.1
28.88
45.10
e6/l
0.42
93
606
108
683
1.87
6.23
5.4
3.4
0.22
0.33
e6/l
0.52
82
510
53
260
2.24
6.13
1.3
1.2
—
—
—
0
0
203
1566
1.80
5.96
10.8
9.8
4.01
3.87
e9/l
0.42
183
1356
115
753
1.82
5.88
5.4
3.4
16.33
126.83
e6/l
0.69
87
568
53
265
2.20
5.85
2.6
1.5
—
—
—
0
0
48
231
2.27
5.81
9.2
9.3
104.79
104.57
mmol/l
0.11
48
231
158
1140
1.76
5.78
16.0
8.9
1.21
1.22
mmol/l
0.63
148
1001
16
31
5.37
5.78
1.6
1.2
—
—
—
0
0
108
697
1.83
5.77
5.3
3.3
—
—
—
0
0
28
104
2.85
5.76
10.9
16.2
—
—
—
0
0
97
611
1.84
5.58
5.4
3.8
7.40
7.40
ph
—
9
100
129
885
1.76
5.58
2.0
1.9
—
—
—
0
0
244
2018
1.86
5.39
4.7
3.7
14.39
14.45
pmol/l
0.15
237
1849
92
576
1.84
5.37
2.7
2.5
2.83
2.89
mg/l
0.07
84
492
83
504
1.87
5.33
3.7
2.7
5.26
8.06
e6/l
0.86
78
445
120
825
1.72
5.04
15.7
8.6
1.32
1.15
inr
0.66
27
246
15
41
3.79
4.98
3.2
4.7
37.89
36.60
%
0.11
15
41
147
1072
1.68
4.95
3.2
2.7
—
—
—
0
0
51
269
2.06
4.90
5.9
4.3
1.60
1.59
%
0.03
51
254
50
262
2.08
4.88
10.2
8.7
24.00
23.63
mmol/l
0.62
50
262
140
1014
1.67
4.79
3.4
2.7
71.08
72.98
nmol/l
0.38
135
931
215
1746
1.70
4.69
8.7
6.6
95.90
89.30
u/l
0.74
208
1642
79
491
1.81
4.66
4.4
2.9
578.79
556.32
mosm/kgh2o
0.31
70
421
91
593
1.75
4.56
4.2
3.2
—
—
—
0
0
44
226
2.10
4.53
3.7
3.6
0.21
0.22
g/l
0.41
44
219
95
633
1.71
4.38
3.1
2.5
—
—
—
0
0
282
2500
2.03
4.33
22.4
12.6
139.44
139.61
mmol/l
0.65
277
2430
23
92
2.62
4.15
2.7
9.3
—
—
—
0
0
282
2509
2.00
4.15
22.5
12.6
3.94
3.94
mmol/l
0.08
275
2428
27
119
2.39
4.00
12.0
12.4
0.64
0.69
%
0.36
27
119
291
2629
2.11
3.92
19.5
11.4
19.15
21.27
mg/l
0.81
241
1940
80
523
1.70
3.91
2.9
2.6
1.79
1.03
mg/l
0.52
66
383
8
11
7.42
3.88
5.5
2.6
—
—
—
0
0
24
102
2.46
3.84
4.4
5.8
0.22
0.41
g/l
0.83
19
59
266
2340
1.79
3.82
5.2
4.3
1.82
1.85
mu/l
0.16
261
2175
54
320
1.83
3.68
21.0
10.8
24.79
24.87
mmol/l
0.08
54
320
23
101
2.38
3.45
3.6
7.6
0.65
0.62
%
0.20
23
101
19
76
2.59
3.44
3.9
2.5
—
—
—
0
0
9
18
5.11
3.39
1.8
2.9
150.36
157.81
ug/l
—
9
18
297
2732
2.12
3.35
15.5
9.8
—
—
—
0
0
99
709
1.57
3.31
2.0
1.7
101.29
97.08
pmol/l
0.36
59
365
202
1693
1.52
3.21
5.7
3.9
—
—
—
0
0
38
211
1.91
3.17
10.6
10.8
1.13
1.29
mmol/l
0.69
38
205
28
140
2.10
3.11
2.2
2.1
11.59
6.17
u/l
0.71
16
105
36
198
1.92
3.09
1.9
1.8
15.91
18.61
iu/l
0.16
22
158
35
191
1.93
3.07
3.5
3.4
69.23
67.47
e9/l
0.13
21
132
42
244
1.83
3.05
19.2
7.0
—
—
—
0
0
153
1224
1.48
2.98
4.4
3.3
0.00
0.00
estimate
-0.00
16
218
24
115
2.17
2.97
1.8
1.3
—
—
—
0
0
72
490
1.60
2.96
3.4
3.3
336.24
6417.97
umol/l
2.15
66
443
151
1210
1.47
2.89
6.6
4.6
0.00
0.00
estimate
-0.00
16
227
6
9
6.77
2.88
1.8
2.6
140.50
151.44
ug/g
—
6
9
313
2990
2.67
2.81
26.4
16.7
6.96
6.68
e9/l
1.54
308
2899
313
2988
2.70
2.81
26.3
16.7
4.52
4.57
e12/l
1.17
307
2897
90
655
1.52
2.75
3.4
3.5
8.09
8.15
mmol/l
0.04
83
584
128
1001
1.46
2.74
3.9
3.0
5.90
6.00
ph
—
10
103
24
120
2.08
2.68
12.5
12.1
1.54
1.27
%
0.50
24
120
210
1811
1.46
2.63
5.2
3.8
10.28
8.99
mm/h
0.78
200
1681
28
151
1.94
2.56
1.9
1.4
—
—
—
0
0
6
11
5.53
2.55
5.5
7.1
—
—
—
0
0
167
1387
1.42
2.53
9.2
5.8
6.27
6.33
mmol/l
0.12
159
1271
148
1207
1.42
2.46
4.1
3.3
0.00
0.00
estimate
0.50
16
227
39
238
1.73
2.43
2.2
1.4
—
—
—
0
0
46
296
1.65
2.36
7.7
4.1
11.47
7.99
umol/l
0.33
40
253
102
791
1.42
2.20
1.6
1.6
—
—
—
0
0
14
61
2.35
2.18
1.9
1.6
—
—
—
0
0
312
2985
2.46
2.17
26.9
17.1
40.02
40.39
%
0.61
299
2847
312
2985
2.46
2.17
26.4
16.8
264.71
260.67
e9/l
0.47
305
2903
60
422
1.52
2.12
1.6
1.4
20.30
20.56
nmol/l
0.05
55
364
11
43
2.61
2.10
5.3
4.6
412.82
353.63
umol/l
0.78
11
38
7
21
3.38
1.97
5.0
3.0
25.86
29.43
umol/l
—
7
21
14
64
2.24
1.97
1.1
3.9
—
—
—
0
0
8
29
2.80
1.80
2.4
3.5
—
—
—
0
0
34
219
1.62
1.77
1.4
1.7
—
—
—
0
0
6
18
3.38
1.75
2.2
1.5
—
—
—
0
0
5
13
3.89
1.72
2.0
2.7
1002.20
650.92
u/ml
—
5
13
34
221
1.60
1.71
1.3
1.6
—
—
—
0
0
34
222
1.59
1.68
1.3
1.7
—
—
—
0
0
6
19
3.20
1.67
1.5
4.4
—
—
—
0
0
34
223
1.59
1.65
1.3
1.7
—
—
—
0
0
167
1451
1.31
1.64
4.0
3.0
—
—
—
0
0
10
42
2.42
1.63
2.6
3.9
3.66
3.96
mmol/l
—
10
42
10
42
2.42
1.63
1.1
5.2
—
—
—
0
0
23
137
1.73
1.60
3.5
2.3
—
—
—
0
0
148
1270
1.31
1.58
13.2
9.5
0.00
0.00
e9/l
0.75
116
1011
55
405
1.43
1.56
2.1
1.6
—
—
—
0
0
13
64
2.07
1.56
5.7
5.7
—
—
—
0
0
63
476
1.40
1.55
3.5
4.0
5.01
11.64
mg/mmol
1.28
40
311
8
33
2.46
1.54
1.1
4.6
—
—
—
0
0
5
15
3.37
1.53
4.4
3.3
66.40
58.40
umol/l
—
5
15
7
27
2.63
1.52
1.7
2.1
—
—
—
0
0
6
21
2.89
1.51
1.5
1.4
13.73
22.66
umol/l
—
6
21
219
1988
1.32
1.51
5.3
4.5
37.40
38.23
mmol/mol
0.87
214
1864
35
237
1.53
1.50
1.9
1.5
—
—
—
0
0
33
221
1.55
1.48
25.5
7.3
9.75
9.56
kpa
0.25
33
212
9
38
2.41
1.47
1.0
1.3
—
—
—
0
0
55
410
1.41
1.46
1.2
1.2
30.37
31.43
iu/ml
0.04
18
122
20
322
0.60
1.44
1.5
1.3
—
—
—
0
0
6
22
2.76
1.44
4.0
2.5
—
—
—
0
0
91
738
1.32
1.44
2.1
2.1
—
—
—
0
0
7
29
2.44
1.40
5.0
2.2
—
—
—
0
0
18
105
1.76
1.36
1.3
2.0
—
—
—
0
0
16
90
1.82
1.35
1.4
1.2
—
—
—
0
0
0
38
0.00
1.35
0.0
1.4
—
—
—
0
0
11
54
2.07
1.34
3.1
11.0
—
—
—
0
0
19
114
1.71
1.31
1.1
1.6
—
10.08
—
0
5
9
43
2.12
1.31
2.0
2.6
—
—
—
0
0
27
179
1.55
1.28
1.4
1.8
—
—
—
0
0
26
172
1.56
1.25
2.0
1.5
—
—
—
0
0
6
25
2.43
1.25
1.0
1.1
—
—
—
0
0
10
49
2.07
1.23
2.8
11.3
77.00
68.30
%
—
10
49
8
37
2.19
1.22
1.0
1.2
—
—
—
0
0
5
19
2.66
1.22
2.0
1.5
—
—
—
0
0
30
207
1.50
1.20
1.4
1.7
—
—
—
0
0
86
710
1.29
1.18
3.2
3.0
2.40
2.37
mmol/l
1.54
81
639
0
35
0.00
1.16
0.0
2.7
—
38.16
—
0
35
5
20
2.52
1.15
1.6
1.3
—
—
—
0
0
8
40
2.02
1.13
1.4
1.1
—
—
—
0
0
42
314
1.39
1.12
2.3
2.4
2.45
2.43
mmol/l
0.67
36
280
58
458
1.32
1.10
3.4
3.4
29.79
85.86
mg/l
1.69
41
307
5
21
2.40
1.09
1.2
1.4
—
—
—
0
0
5
21
2.40
1.09
1.0
1.1
—
—
—
0
0
9
49
1.86
0.99
1.4
1.6
—
—
—
0
0
280
2681
1.34
0.99
11.9
8.9
28.09
26.37
u/l
0.42
271
2589
9
50
1.82
0.97
4.6
3.0
12.73
5.81
u/ml
—
9
50
47
367
1.33
0.97
3.7
4.2
2.00
1.85
ug/l
0.14
42
327
27
192
1.44
0.96
2.9
2.5
134.75
2019.57
u/l
0.91
13
75
0
32
0.00
0.95
0.0
13.6
—
5.98
—
0
24
45
356
1.31
0.86
1.4
1.4
413.33
393.43
titre
—
6
67
13
80
1.65
0.86
1.4
1.2
—
—
—
0
0
8
45
1.80
0.85
1.8
3.7
61.75
55.09
%
—
8
45
36
277
1.34
0.83
1.8
1.5
935.94
1189.30
nmol/l
1.30
31
208
6
32
1.89
0.82
3.2
16.0
11.98
12.74
%
—
6
32
12
74
1.65
0.79
1.1
1.2
—
—
—
0
0
13
82
1.61
0.79
1.1
1.3
—
—
—
0
0
21
149
1.44
0.78
4.0
3.1
—
—
—
0
0
0
27
0.00
0.78
0.0
1.0
—
—
—
0
0
60
500
1.25
0.77
3.1
3.2
—
—
—
0
0
76
880
0.82
0.77
2.3
2.3
—
—
—
0
0
22
158
1.42
0.77
1.3
2.2
—
—
—
0
0
5
24
2.10
0.75
5.8
2.0
—
—
—
0
0
5
25
2.02
0.73
4.8
3.8
1.68
3.53
nmol/l
—
5
25
5
25
2.02
0.73
1.8
1.6
—
—
—
0
0
11
69
1.62
0.69
1.5
1.3
—
—
—
0
0
14
202
0.68
0.68
4.7
3.5
—
—
—
0
0
64
546
1.21
0.67
3.5
3.1
1.01
1.02
kg/l
0.34
12
88
7
43
1.64
0.67
1.0
1.5
—
—
—
0
0
10
62
1.63
0.66
1.7
1.1
—
46.40
—
0
16
15
104
1.46
0.63
1.9
2.2
—
—
—
0
0
10
63
1.61
0.62
6.6
8.3
—
—
—
0
0
5
30
1.68
0.61
5.0
5.8
1.65
1.90
ug/l
—
5
30
67
580
1.20
0.61
2.1
1.7
—
—
—
0
0
0
20
0.00
0.60
0.0
1.1
—
—
—
0
0
0
21
0.00
0.60
0.0
1.1
—
162.32
—
0
21
8
52
1.55
0.60
1.9
2.0
—
—
—
0
0
18
132
1.39
0.58
1.1
1.2
5.32
5.41
u/ml
—
10
100
48
405
1.22
0.57
1.2
1.2
12.02
7.05
u/ml
0.21
16
160
11
73
1.52
0.57
1.8
1.7
9.18
7.76
iu/l
—
6
25
13
90
1.46
0.56
2.1
1.7
—
—
—
0
0
42
351
1.23
0.55
1.2
1.2
—
—
—
0
0
9
61
1.49
0.54
1.0
1.2
—
—
—
0
0
7
45
1.57
0.49
1.6
3.2
5.34
4.33
e9/l
—
7
45
19
146
1.32
0.48
1.5
1.2
—
—
—
0
0
12
85
1.43
0.47
2.0
1.6
—
—
—
0
0
87
789
1.14
0.45
1.8
1.6
2.00
1.98
g/l
0.05
52
443
7
50
1.41
0.45
1.1
1.1
—
—
—
0
0
10
139
0.71
0.43
9.8
3.6
1.23
1.23
mmol/l
—
10
117
12
87
1.39
0.43
4.2
2.7
—
—
—
0
0
225
2169
1.12
0.41
4.2
3.5
5.78
5.69
mmol/l
0.34
215
1999
0
17
0.00
0.41
0.0
2.5
—
—
—
0
0
0
18
0.00
0.40
0.0
8.4
—
8.15
—
0
18
20
160
1.27
0.39
1.7
1.7
—
—
—
0
0
5
37
1.36
0.37
1.8
1.6
—
—
—
0
0
6
44
1.37
0.34
1.2
1.1
—
—
—
0
0
18
145
1.26
0.34
1.2
1.2
1.31
4.03
u/ml
1.37
13
100
11
82
1.35
0.34
1.1
1.2
—
—
—
0
0
13
165
0.78
0.33
7.5
4.7
1.14
0.57
%
—
7
63
25
211
1.20
0.32
2.9
2.7
0.69
0.75
ug/l
0.17
16
120
11
83
1.34
0.32
1.1
1.2
—
—
—
0
0
12
92
1.32
0.32
1.4
1.7
—
—
—
0
0
16
129
1.25
0.31
1.1
1.2
0.36
0.79
u/ml
—
8
90
15
185
0.80
0.30
1.3
1.4
—
—
—
0
0
23
194
1.20
0.30
2.1
2.2
—
20.05
—
0
12
12
152
0.78
0.30
1.0
1.1
—
—
—
0
0
10
128
0.77
0.27
1.1
1.1
—
—
—
0
0
21
178
1.19
0.27
1.1
1.2
—
31.12
—
0
5
19
160
1.20
0.26
1.4
1.2
—
—
—
0
0
21
179
1.19
0.25
1.9
1.6
—
—
—
0
0
9
74
1.22
0.25
1.0
1.1
—
—
—
0
0
31
274
1.15
0.25
1.3
1.2
—
—
—
0
0
27
237
1.15
0.24
1.2
1.3
—
—
—
0
0
5
40
1.25
0.22
5.8
3.2
—
—
—
0
0
0
11
0.00
0.21
0.0
10.9
—
—
—
0
0
0
11
0.00
0.21
0.0
5.1
—
—
—
0
0
0
11
0.00
0.21
0.0
1.2
—
—
—
0
0
0
11
0.00
0.21
0.0
24.5
—
0.48
—
0
11
0
11
0.00
0.21
0.0
2.5
—
—
—
0
0
0
11
0.00
0.21
0.0
1.3
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
0
10
0.00
0.21
0.0
1.3
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
0
10
0.00
0.21
0.0
1.3
—
—
—
0
0
0
12
0.00
0.21
0.0
1.3
—
2.84
—
0
12
0
14
0.00
0.20
0.0
10.5
—
263.17
—
0
6
0
14
0.00
0.20
0.0
1.1
—
—
—
0
0
7
61
1.15
0.17
1.1
1.0
—
—
—
0
0
42
453
0.92
0.17
2.4
2.7
59.92
94.67
ug/g
1.13
36
358
10
82
1.23
0.17
1.7
2.3
—
—
—
0
0
228
2243
1.06
0.15
4.5
3.7
4.58
4.68
mmol/l
0.91
223
2107
13
112
1.17
0.14
1.1
1.3
—
—
—
0
0
12
139
0.86
0.14
2.5
2.3
45.62
32.03
u/ml
0.43
12
133
18
160
1.13
0.14
6.7
5.1
0.00
0.17
%
—
8
54
5
44
1.14
0.10
7.0
3.7
—
—
—
0
0
5
44
1.14
0.10
1.0
1.0
—
—
—
0
0
5
45
1.11
0.10
3.2
1.2
—
—
—
0
0
64
662
0.96
0.08
3.3
2.9
—
—
—
0
0
5
64
0.78
0.08
6.6
3.2
20.00
2218.84
u/ml
—
5
57
84
861
0.97
0.07
1.3
1.6
5.34
2.60
u/ml
0.25
14
204
59
609
0.96
0.07
4.2
3.5
0.00
0.00
estimate
0.50
15
223
18
167
1.08
0.07
6.7
5.1
0.13
0.13
%
—
8
60
9
102
0.88
0.06
2.6
1.5
—
—
—
0
0
14
151
0.92
0.05
3.8
4.2
2.93
10.52
ug/l
—
7
117
54
527
1.03
0.04
1.6
1.8
—
—
—
0
0
44
452
0.97
0.04
2.0
1.8
—
—
—
0
0
17
179
0.95
0.03
7.0
4.9
0.88
0.78
%
—
8
72
25
259
0.96
0.02
2.2
1.9
—
—
—
0
0
16
167
0.96
0.01
4.6
5.0
—
—
—
0
0
226
2259
1.00
0.00
4.9
4.0
2.81
2.82
mmol/l
0.08
220
2109
213
2131
1.00
0.00
4.0
3.4
1.21
1.24
mmol/l
0.19
206
1983
69
693
0.99
0.00
3.7
2.9
15.53
20.55
ng/l
0.76
39
379
34
336
1.01
0.00
1.7
1.6
547.25
22867343.28
pmol/l
0.50
28
293
222
2225
0.99
0.00
4.4
3.7
1.42
1.46
mmol/l
0.80
215
2081
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.8
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.4
—
4.30
—
0
5
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
9
99
0.91
-0.00
2.2
1.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
3.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
6
67
0.89
-0.00
1.3
1.3
55.33
63.01
pmol/l
—
6
62
9
99
0.91
-0.00
2.2
1.4
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.8
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
7
0.00
-0.00
0.0
10.1
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
3.1
—
—
—
0
0

Mortality – FinRegistry

↥

Association

Association between endpoint Q17_OTHER_CONGEN_MALFO_NOT_ELSEW_CLASSIFIED and mortality.

Females

Parameter HR [95% CI] p-value
Q17_OTHER_CONGEN_MALFO_NOT_ELSEW_CLASSIFIED 2.187 [1.37, 3.49] 0.001
Birth year 1.0 [0.99, 1.01] 0.963

During the follow-up period (1.1.1998 — 31.12.2019), 53 out of 1318 females with Q17_OTHER_CONGEN_MALFO_NOT_ELSEW_CLASSIFIED died.

Males

Parameter HR [95% CI] p-value
Q17_OTHER_CONGEN_MALFO_NOT_ELSEW_CLASSIFIED 2.337 [1.7, 3.21] < 0.001
Birth year 0.989 [0.98, 1.0] 0.018

During the follow-up period (1.1.1998 — 31.12.2019), 93 out of 1304 males with Q17_OTHER_CONGEN_MALFO_NOT_ELSEW_CLASSIFIED died.

Mortality risk

Mortality risk for people of age

years, who have Q17_OTHER_CONGEN_MALFO_NOT_ELSEW_CLASSIFIED.

N-year risk Females Males
1 0.212% 0.481%
5 1.422% 2.848%
10 3.576% 6.989%
15 6.823% 13.087%
20 12.109% 21.146%

Relationships between endpoints

↥

Index endpoint: Q17_OTHER_CONGEN_MALFO_NOT_ELSEW_CLASSIFIED – Other congenital malformations, not elsewhere classified

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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