pharynx cancer: A primary or metastatic malignant neoplasm that affects the pharynx.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
272 |
4. Check minimum number of eventsNone |
272 |
5. Include endpointsNone |
272 |
6. Filter based on genotype QC (FinnGen only) |
272 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- D10
- Name in latin
- Neoplasma benignum pharyngis non specificatum
Similar endpoints
↥List of similar endpoints to
Benign neoplasm: Pharynx, unspecified
based on the number of shared cases.
Similar with more cases:
- Benign neoplasm: Pharynx, unspecified
- Benign neoplasm of mouth and pharynx
- Benign neoplasm of mouth and pharynx
- Benign neoplasms
- Benign neoplasms
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1705 | 921 | 768 |
| Only index persons | 1541 | 851 | 690 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.02 | 0.03 | 0.02 |
| Only index persons | 0.03 | 0.03 | 0.03 |
| Median age at first event (years) | |||
| Whole population | 52.22 | 51.72 | 52.86 |
| Only index persons | 51.94 | 51.56 | 52.40 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 272 | 162 | 110 |
| Unadjusted period prevalence (%) | 0.05 | 0.06 | 0.05 |
| Median age at first event (years) | 55.51 | 53.76 | 58.09 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 236
- Matched controls
- 2357
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
D10.9
ICD-10 Finland
Benign neoplasm: Pharynx, unspecified
+∞
292.7
216
*
ENA10
NOMESCO Finland
Biopsy of pharynx
123.4
39.1
41
*
21099
ICD-8 Finland
Benign neoplasm of buccal cavity and pharynx, Pharynx unspecified
+∞
15.8
15
*
EJA10
NOMESCO Finland
Biopsy of tongue or floor of mouth
13.4
12.4
21
17
UDQ12
NOMESCO Finland
Flexible laryngoscopy
5.8
11.6
33
64
JDB10
NOMESCO Finland
Percutaneous gastrostomy
16.5
11.0
17
11
EHA10
NOMESCO Finland
Biopsy of palate
27.3
9.9
13
5
EMA10
NOMESCO Finland
Biopsy of tonsil
57.4
9.7
11
*
ENB00
NOMESCO Finland
Excision or exploration of lesion of pharynx
104.0
9.5
10
*
UJC01
NOMESCO Finland
Scopy of lower throat
16.4
9.1
14
9
UDH02
NOMESCO Finland
Rhinopharyngoscopy
4.2
8.8
33
87
EP1CG
NOMESCO Finland
Extensive MRI examination of soft tissue of neck with high intesity magnet
17.1
8.7
13
8
GDA98
NOMESCO Finland
Other bronchoscopic incision, excision of lesion or repair of lung
93.2
8.5
9
*
504
Kela drug reimbursment
Conditions requiring daily forced enteral nutrition
10.5
7.1
13
13
R21
ICPC
Throat symptom/complaint
2.5
7.1
58
268
D10.19
ICD-10 Finland
Benign tumor of the tongue UNS
23.3
6.7
9
*
EP1DG
NOMESCO Finland
Very extensive examination of soft tissue of neck with high intesity magnet
12.7
6.6
11
9
D10.09
ICD-10 Finland
Benign tumor of the lip UNS
71.7
6.5
7
*
WX408
NOMESCO Finland
General anesthesy, balanced
2.2
6.4
77
428
EN1BD
NOMESCO Finland
Very extensive CT examination of mouth and soft tissues of neck
7.4
6.3
14
20
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
83
431
2.33
8.79
1.7
1.5
—
—
—
0
0
156
1072
2.07
7.85
7.1
6.1
1.2
1.2
mmol/l
0.31
123
903
21
54
4.13
7.58
1.2
1.3
—
—
—
0
0
141
976
1.92
6.52
6.5
5.3
1.2
1.2
mmol/l
0.59
126
886
133
930
1.84
5.72
4.8
4.2
36.0
35.7
g/l
0.21
125
870
129
909
1.80
5.29
2.4
2.2
74.5
77.0
nmol/l
0.43
114
807
33
145
2.45
4.94
1.6
1.5
—
—
—
0
0
68
420
1.83
4.17
1.6
1.7
528.3
460.9
pmol/l
0.88
51
359
43
242
1.92
3.49
7.3
7.1
1.7
1.1
mmol/l
0.47
30
196
100
724
1.60
3.33
3.8
3.3
2.3
2.4
mmol/l
0.85
87
635
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
15
54
2.88
3.31
2.1
2.3
0.3
0.4
u/ml
—
8
31
31
158
2.09
3.30
4.4
3.1
82.0
73.2
ng/l
0.36
24
138
231
2050
1.84
3.26
5.9
4.7
2.1
1.9
mu/l
0.73
208
1855
108
801
1.58
3.23
3.7
3.0
—
—
—
0
0
265
2506
3.23
3.23
28.0
19.7
132.9
135.7
g/l
2.39
260
2468
53
329
1.76
3.15
1.7
1.9
—
—
—
0
0
59
379
1.71
3.11
1.3
1.3
18.7
32.9
iu/ml
1.10
16
126
133
1043
1.54
3.06
4.5
4.0
—
—
—
0
0
59
382
1.70
3.02
2.9
2.6
0.9
0.8
e6/l
0.14
40
213
197
1692
1.60
2.96
5.0
4.0
14.8
14.8
pmol/l
0.02
172
1522
80
563
1.60
2.95
2.5
2.6
329.9
5941.8
umol/l
2.18
66
481
9
22
4.19
2.91
1.4
1.3
—
—
—
0
0
247
2259
2.02
2.89
19.3
13.4
25.7
22.8
mg/l
0.79
212
1778
231
2074
1.75
2.81
20.5
14.1
40.5
40.3
%
0.13
159
1544
194
1673
1.56
2.74
4.3
3.9
14.6
11.5
mm/h
1.56
177
1524
85
632
1.50
2.40
3.8
3.0
0.4
0.5
e6/l
0.20
65
472
53
354
1.62
2.39
3.1
2.7
1.8
2.5
e6/l
0.49
35
187
17
78
2.26
2.36
1.1
1.1
—
—
—
0
0
59
406
1.58
2.36
3.1
2.9
2.4
2.4
mmol/l
0.25
54
358
11
41
2.75
2.30
3.2
5.9
—
159.0
—
0
6
38
235
1.72
2.29
1.8
1.9
—
—
—
0
0
81
604
1.49
2.24
3.1
3.0
2351.1
1244.2
ng/l
0.46
65
506
155
1310
1.43
2.17
10.8
9.2
4.3
4.1
e9/l
0.56
136
1155
196
1736
1.46
2.08
8.4
7.4
76.4
79.2
u/l
0.68
190
1619
16
76
2.17
2.07
1.1
1.1
—
—
—
0
0
37
234
1.67
2.07
1.8
1.8
—
—
—
0
0
11
44
2.56
2.04
1.4
1.4
—
—
—
0
0
28
166
1.77
1.96
2.7
2.7
68.8
62.7
ml/min/173m2
—
9
76
11
45
2.51
1.95
1.8
1.9
127.0
125.5
g/l
—
5
29
95
751
1.41
1.89
2.7
2.9
28.0
33.4
u/l
1.45
90
716
67
497
1.46
1.88
1.4
1.5
22.7
21.1
nmol/l
0.27
55
410
130
1085
1.38
1.86
5.5
4.8
0.0
0.0
estimate
0.00
24
215
15
73
2.12
1.84
2.7
3.0
—
—
—
0
0
106
859
1.38
1.81
3.2
3.7
26.0
42.3
ng/l
1.00
74
586
22
125
1.83
1.78
1.0
1.0
—
—
—
0
0
129
1084
1.36
1.74
4.2
3.5
0.0
0.0
estimate
0.00
23
210
230
2132
1.51
1.67
18.0
12.5
85.4
82.9
ml/min/173m2
0.87
181
1728
70
535
1.42
1.66
1.3
1.2
1.6
1.3
u/ml
0.11
15
147
22
128
1.78
1.66
1.7
1.3
—
—
—
0
0
130
1100
1.35
1.65
4.1
3.5
0.0
0.0
estimate
0.50
23
198
69
527
1.41
1.65
3.0
2.2
—
—
—
0
0
7
26
2.74
1.59
2.6
3.0
2.8
2.7
nmol/l
—
7
26
6
20
3.04
1.59
1.2
1.0
—
—
—
0
0
0
42
0.00
1.54
0.0
1.2
—
1.4
—
0
15
10
45
2.27
1.48
1.6
1.2
—
—
—
0
0
10
45
2.27
1.48
1.6
1.2
—
—
—
0
0
68
531
1.37
1.42
2.0
1.9
2.7
3.1
mg/l
0.66
58
452
18
104
1.78
1.41
2.8
2.6
1.4
1.3
%
0.12
18
104
73
578
1.36
1.40
4.1
3.8
0.0
0.0
estimate
0.00
22
207
21
128
1.69
1.38
1.7
2.2
—
—
—
0
0
0
37
0.00
1.35
0.0
1.1
—
—
—
0
0
52
392
1.40
1.33
2.0
1.6
1218.8
1271.8
nmol/l
0.17
36
294
17
99
1.76
1.30
1.3
2.2
—
—
—
0
0
25
164
1.58
1.25
5.0
2.7
4.3
4.2
kpa
0.14
25
158
29
198
1.52
1.23
5.7
3.4
6.2
5.9
kpa
0.89
29
193
33
233
1.47
1.20
4.1
3.3
—
—
—
0
0
114
984
1.27
1.15
3.0
2.5
114.3
116.2
ug/l
0.03
99
901
37
271
1.42
1.12
26.8
19.8
1.0
1.3
inr
—
6
43
20
128
1.61
1.12
1.6
1.4
—
—
—
0
0
18
113
1.63
1.08
1.5
1.7
—
—
—
0
0
48
371
1.36
1.07
1.4
1.3
16.8
8.3
u/ml
0.32
16
152
11
60
1.87
1.04
1.4
1.2
—
—
—
0
0
250
2402
1.50
1.04
12.9
10.2
24.8
26.7
u/l
1.30
243
2316
5
22
2.30
1.04
2.2
2.0
19.0
16.1
ug/l
—
5
22
9
47
1.95
1.03
1.1
1.4
—
49.1
—
0
6
16
99
1.65
1.02
6.1
3.5
25.0
25.3
mmol/l
0.14
16
99
7
35
2.03
1.00
1.7
1.5
—
—
—
0
0
32
234
1.42
0.99
2.9
2.3
63.2
32.1
u/l
0.51
24
197
12
69
1.77
0.98
1.2
1.7
—
—
—
0
0
61
498
1.29
0.94
4.1
4.1
25.7
21.2
%
1.16
26
223
228
2170
1.31
0.89
5.0
4.4
6.2
5.9
mmol/l
1.17
208
1991
99
863
1.23
0.88
2.2
1.9
99.2
95.6
pmol/l
0.28
48
424
6
31
1.96
0.85
1.3
1.2
—
—
—
0
0
6
31
1.96
0.85
1.2
1.3
—
—
—
0
0
12
73
1.67
0.83
3.8
2.1
3841.1
3511.8
u/l
—
7
27
6
32
1.89
0.82
1.5
1.7
—
—
—
0
0
6
32
1.89
0.82
1.3
1.2
—
—
—
0
0
35
270
1.34
0.81
11.3
7.5
—
—
—
0
0
13
82
1.61
0.79
1.8
2.3
—
—
—
0
0
22
158
1.43
0.77
3.3
2.4
12.8
13.8
nmol/l
0.25
17
144
7
38
1.86
0.74
1.4
1.6
—
—
—
0
0
12
76
1.61
0.73
1.2
1.9
—
—
—
0
0
5
26
1.94
0.71
1.2
1.1
—
—
—
0
0
216
2061
1.23
0.69
7.2
5.6
41.4
39.6
mmol/mol
1.65
197
1921
5
28
1.80
0.66
1.4
1.3
—
—
—
0
0
15
103
1.48
0.66
9.1
3.7
57.3
47.5
%
0.85
15
103
5
30
1.68
0.61
1.2
1.4
—
—
—
0
0
5
30
1.68
0.61
1.0
1.5
0.5
0.5
nmol/l
—
5
23
5
30
1.68
0.61
2.4
3.6
—
—
—
0
0
0
20
0.00
0.60
0.0
2.4
—
—
—
0
0
8
54
1.50
0.58
1.1
1.2
—
—
—
0
0
10
65
1.56
0.56
1.7
1.8
—
—
—
0
0
6
37
1.64
0.56
1.8
1.5
—
—
—
0
0
9
61
1.49
0.54
1.4
1.5
—
—
—
0
0
11
74
1.51
0.54
1.4
1.3
—
—
—
0
0
6
39
1.55
0.53
1.0
1.4
—
—
—
0
0
6
39
1.55
0.53
1.0
1.5
3.4
115.8
u/ml
—
6
34
9
63
1.44
0.53
1.6
1.3
—
—
—
0
0
7
46
1.54
0.48
1.7
1.6
—
—
—
0
0
11
77
1.45
0.46
1.4
1.7
—
180.0
—
0
5
5
32
1.57
0.42
1.0
1.1
—
—
—
0
0
92
844
1.14
0.42
4.3
3.5
—
—
—
0
0
43
372
1.19
0.42
2.7
2.9
0.7
0.7
ug/l
0.29
19
241
35
297
1.20
0.42
2.5
2.0
19.2
22.5
%
0.73
29
256
11
79
1.41
0.41
2.5
2.3
848.6
323.5
ug/l
0.28
11
74
0
16
0.00
0.41
0.0
1.1
—
—
—
0
0
0
16
0.00
0.41
0.0
1.2
—
—
—
0
0
8
60
1.34
0.40
1.8
1.6
—
—
—
0
0
0
18
0.00
0.40
0.0
1.4
—
4.4
—
0
7
9
69
1.31
0.37
1.3
1.5
—
—
—
0
0
46
405
1.16
0.37
3.7
3.4
40.5
205.9
ng/l
1.83
37
303
152
1446
1.12
0.37
3.3
3.2
—
—
—
0
0
6
43
1.40
0.35
1.8
1.6
—
—
—
0
0
11
82
1.36
0.34
1.6
1.9
0.5
4.8
ug/l
0.73
11
75
6
45
1.34
0.34
1.3
1.5
—
—
—
0
0
6
46
1.31
0.33
1.0
1.2
—
—
—
0
0
56
506
1.13
0.33
1.7
1.7
2.2
1.2
mg/l
1.02
41
390
7
56
1.26
0.29
2.1
1.7
—
—
—
0
0
7
56
1.26
0.29
1.9
1.3
—
—
—
0
0
67
618
1.11
0.28
2.0
1.7
1.7
1.4
mmol/l
1.27
58
522
9
75
1.21
0.25
1.4
1.9
—
—
—
0
0
11
87
1.28
0.24
1.7
1.4
—
—
—
0
0
17
201
0.84
0.24
1.6
1.6
—
—
—
0
0
196
1910
1.09
0.24
24.6
16.5
14.0
13.7
%
0.94
191
1882
0
11
0.00
0.21
0.0
1.9
—
—
—
0
0
0
11
0.00
0.21
0.0
2.2
—
786.3
—
0
11
0
11
0.00
0.21
0.0
1.5
—
—
—
0
0
0
11
0.00
0.21
0.0
1.9
—
—
—
0
0
0
11
0.00
0.21
0.0
1.5
—
13.2
—
0
11
0
11
0.00
0.21
0.0
1.9
—
—
—
0
0
0
10
0.00
0.21
0.0
1.2
—
384.6
—
0
5
0
12
0.00
0.21
0.0
1.5
—
—
—
0
0
0
13
0.00
0.21
0.0
1.9
—
—
—
0
0
0
13
0.00
0.21
0.0
1.9
—
—
—
0
0
0
13
0.00
0.21
0.0
1.9
—
—
—
0
0
0
13
0.00
0.21
0.0
1.6
—
6.9
—
0
5
0
13
0.00
0.21
0.0
1.2
—
—
—
0
0
0
13
0.00
0.21
0.0
1.9
—
—
—
0
0
0
14
0.00
0.20
0.0
1.9
—
—
—
0
0
0
14
0.00
0.20
0.0
1.9
—
—
—
0
0
0
14
0.00
0.20
0.0
3.9
—
—
—
0
0
226
2226
1.09
0.17
4.9
4.4
4.7
4.7
mmol/l
0.13
209
2071
157
1532
1.06
0.15
3.3
3.0
39.9
47.6
u/l
0.92
148
1432
224
2209
1.08
0.15
4.8
4.3
1.4
1.5
mmol/l
0.57
204
2043
13
150
0.86
0.15
1.1
1.2
164.0
188.3
iu/ml
—
5
54
229
2262
1.08
0.14
5.6
4.8
2.7
2.8
mmol/l
0.25
208
2092
11
128
0.85
0.14
1.7
1.5
—
—
—
0
0
66
635
1.05
0.10
4.3
4.5
2.0
2.6
ug/l
0.51
58
565
17
154
1.11
0.10
1.8
1.2
—
37.9
—
0
12
5
47
1.07
0.09
1.4
1.2
—
—
—
0
0
6
57
1.05
0.08
1.0
1.4
—
—
—
0
0
7
81
0.86
0.07
2.1
1.5
—
—
—
0
0
27
284
0.95
0.06
1.5
1.8
1.6
1.5
%
0.33
21
247
25
252
0.99
0.00
3.3
2.0
—
—
—
0
0
12
121
0.99
0.00
1.8
2.9
75.3
33.1
u/ml
0.50
12
116
213
2132
1.00
0.00
4.3
3.9
1.3
1.3
mmol/l
0.51
195
1962
37
365
1.02
0.00
1.6
1.5
—
—
—
0
0
27
274
0.98
0.00
4.7
4.5
27.6
32.3
%
1.86
15
180
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
27.5
—
0
5
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
0.00
0.0
1.6
—
—
—
0
0
7
69
1.01
0.00
1.6
1.4
—
—
—
0
0
0
9
0.00
0.00
0.0
1.0
—
1527.1
—
0
9
0
7
0.00
0.00
0.0
1.3
—
—
—
0
0
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
6
64
0.94
0.00
1.3
3.4
—
4.2
—
0
5
0
8
0.00
0.00
0.0
1.3
—
—
—
0
0
7
74
0.94
0.00
2.0
1.4
—
—
—
0
0
0
9
0.00
0.00
0.0
1.2
—
—
—
0
0
0
9
0.00
0.00
0.0
1.4
—
—
—
0
0
0
8
0.00
0.00
0.0
1.6
—
—
—
0
0
6
61
0.98
0.00
2.0
1.6
—
—
—
0
0
11
110
1.00
0.00
1.9
2.4
0.1
0.2
e6/l
0.42
11
105
0
7
0.00
0.00
0.0
1.3
—
—
—
0
0
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
0
9
0.00
0.00
0.0
7.9
—
—
—
0
0
0
9
0.00
0.00
0.0
1.3
—
—
—
0
0
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
7
74
0.94
0.00
2.0
1.5
—
—
—
0
0
7
74
0.94
0.00
2.0
1.5
—
—
—
0
0
28
280
1.00
0.00
3.6
2.2
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint CD2_BENIGN_PHARYNX_NOS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| CD2_BENIGN_PHARYNX_NOS | 1.166 [0.87, 1.55] | 0.296 |
| Birth year | 0.993 [0.98, 1.0] | 0.132 |
During the follow-up period (1.1.1998 — 31.12.2019), 79 out of 643 females with CD2_BENIGN_PHARYNX_NOS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| CD2_BENIGN_PHARYNX_NOS | 2.047 [1.56, 2.68] | < 0.001 |
| Birth year | 0.991 [0.98, 1.0] | 0.064 |
During the follow-up period (1.1.1998 — 31.12.2019), 120 out of 559 males with CD2_BENIGN_PHARYNX_NOS died.
Mortality risk
Mortality risk for people of age
years, who have CD2_BENIGN_PHARYNX_NOS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.078% | 0.443% |
| 5 | 0.59% | 2.697% |
| 10 | 1.432% | 6.434% |
| 15 | 2.974% | 12.222% |
| 20 | 5.547% | 19.808% |
Relationships between endpoints
↥Index endpoint: CD2_BENIGN_PHARYNX_NOS – Benign neoplasm: Pharynx, unspecified
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data