No definition available.
Other specified/unspecified nutritional deficiencies
EFO MESH Endpoint Browser PheWeb
E4_NUTRI_DEF_NAS
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
268 |
4. Check minimum number of eventsNone |
268 |
5. Include endpointsNone |
268 |
6. Filter based on genotype QC (FinnGen only) |
268 |
Control definitions (FinnGen only)
- Control exclude
- E4_NUTRIDEF
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
Similar endpoints
↥List of similar endpoints to
Other specified/unspecified nutritional deficiencies
based on the number of shared cases.
Similar with more cases:
- Other nutritional deficiencies
- Endocrine, nutritional and metabolic diseases
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 2818 | 1684 | 1106 |
| Only index persons | 2159 | 1300 | 859 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.04 | 0.05 | 0.03 |
| Only index persons | 0.04 | 0.05 | 0.03 |
| Median age at first event (years) | |||
| Whole population | 33.04 | 38.23 | 24.56 |
| Only index persons | 25.04 | 32.24 | 14.14 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 268 | 162 | 106 |
| Unadjusted period prevalence (%) | 0.05 | 0.06 | 0.05 |
| Median age at first event (years) | 26.17 | 24.50 | 28.72 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 248
- Matched controls
- 2478
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
26998
ICD-8 Finland
Other nutritional deficiency, Aliae definitae
+∞
207.6
169
*
26999
ICD-8 Finland
Other nutritional deficiency, Other and unspecified
+∞
43.0
40
*
K90.0
ICD-10 Finland
Coeliac disease
25.8
35.7
50
24
E63.9
ICD-10 Finland
Nutritional deficiency, unspecified
+∞
21.1
20
*
Y0599
ICD-8 Finland
Investigation of digestive system
20.6
21.0
31
17
5790A
ICD-9 Finland
Intestinal malabsorption, Coeliac disease
114.2
19.9
21
*
E63.8
ICD-10 Finland
Other specified nutritional deficiencies
+∞
14.7
14
*
26900
ICD-8 Finland
Other nutritional deficiency, Sprue and steatorrhoea
79.6
13.7
15
*
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.9
11.9
93
430
26910
ICD-8 Finland
Other nutritional deficiency, Malabsorption syndrome, unspecified
51.9
8.7
10
*
56310
ICD-8 Finland
Chronic enteritis and ulcerative colitis, Ulcerative colitis
82.5
7.5
8
*
78880
ICD-8 Finland
Other general symptoms, Pyrexia of unknown origin
71.6
6.5
7
*
28009
ICD-8 Finland
Iron deficiency anaemias, Unspecified
18.6
6.3
9
5
A03CA02
ATC
clidinium and psycholeptics; oral
4.3
6.3
22
55
00919
ICD-8 Finland
Diarrhoeal disease, Diarrhoea
+∞
6.3
6
*
L04AD02
ATC
tacrolimus; systemic (calcineurin inhibitors)
27.4
6.3
8
*
E66.01
ICD-10 Finland
Obesity due to excess calories
13.0
6.1
10
8
00920
ICD-8 Finland
Diarrhoeal disease, Gastroenteritis (acuta) (infectiosa)
5.8
6.1
16
29
Mortality – FinRegistry
↥Association
Association between endpoint E4_NUTRI_DEF_NAS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_NUTRI_DEF_NAS | 3.366 [2.28, 4.96] | < 0.001 |
| Birth year | 0.992 [0.98, 1.0] | 0.064 |
During the follow-up period (1.1.1998 — 31.12.2019), 126 out of 230 females with E4_NUTRI_DEF_NAS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_NUTRI_DEF_NAS | 4.555 [2.46, 8.43] | < 0.001 |
| Birth year | 0.986 [0.98, 1.0] | 0.005 |
During the follow-up period (1.1.1998 — 31.12.2019), 93 out of 157 males with E4_NUTRI_DEF_NAS died.
Mortality risk
Mortality risk for people of age
years, who have E4_NUTRI_DEF_NAS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.247% | 0.866% |
| 5 | 1.609% | 5.4% |
| 10 | 4.136% | 12.203% |
| 15 | 8.068% | 22.754% |
| 20 | 14.903% | 35.897% |
Relationships between endpoints
↥Index endpoint: E4_NUTRI_DEF_NAS – Other specified/unspecified nutritional deficiencies
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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