alcoholic neuropathy: A condition where damage to the peripheral nervous system (including the peripheral elements of the autonomic nervous system) is associated with chronic ingestion of alcoholic beverages. The disorder may be caused by a direct effect of alcohol, an associated nutritional deficiency, or a combination of factors. Clinical manifestations include variable degrees of weakness; ATROPHY; PARESTHESIAS; pain; loss of reflexes; sensory loss; diaphoresis; and postural hypotension. (From Arch Neurol 1995;52(1):45-51; Adams et al., Principles of Neurology, 6th ed, p1146)
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519972 |
1. Apply sex-specific ruleNone |
519972 |
2. Check conditionsNone |
519972 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
363 |
4. Check minimum number of eventsNone |
363 |
5. Include endpointsNone |
363 |
6. Filter based on genotype QC (FinnGen only) |
354 |
Control definitions (FinnGen only)
- Control exclude
- G6_POLYNEU
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- G62
- Name in latin
- Polyneuropathia alcoholica
Similar endpoints
↥List of similar endpoints to
Alcohol induced polyneuropathy
based on the number of shared cases.
Similar with more cases:
- Polyneuropathies and other disorders of the peripheral nervous system
- Alcohol use disorder, Swedish definition
- Alcohol related diseases, tilastokeskus definition
- Alcohol related diseases and deaths, all endpoints
- Neurological diseases
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 4609 | 835 | 3665 |
| Only index persons | 3095 | 628 | 2467 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.09 | 0.02 | 0.10 |
| Only index persons | 0.08 | 0.02 | 0.09 |
| Median age at first event (years) | |||
| Whole population | 57.12 | 56.02 | 57.32 |
| Only index persons | 57.57 | 57.05 | 57.70 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 354 | 69 | 285 |
| Unadjusted period prevalence (%) | 0.11 | 0.02 | 0.13 |
| Median age at first event (years) | 58.49 | 55.76 | 59.15 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 363
- Matched controls
- 3630
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
G62.1
ICD-10 Finland
Alcoholic polyneuropathy
11924.4
307.7
333
*
G62.9
ICD-10 Finland
Polyneuropathy, unspecified
139.3
214.3
108
11
F10.1
ICD-10 Finland
Mental and behavioural disorders due to use of alcohol, Harmful use
24.6
213.7
197
167
G31.2
ICD-10 Finland
Degeneration of nervous system due to alcohol
62.8
125.9
71
14
F10.20
ICD-10 Finland
Alcohol dependence currently independent
30.8
116.1
80
33
F10.25
ICD-10 Finland
Alcohol dependence continuous use
24.3
104.6
79
41
K70.3
ICD-10 Finland
Alcoholic cirrhosis of liver
30.9
94.1
64
25
F10.29
ICD-10 Finland
Addiction caused by alcohol UNS
16.3
89.3
83
65
P15
ICPC
Chronic alcohol abuse
14.8
82.8
81
69
F10.24
ICD-10 Finland
Alcohol depence active use
22.7
73.4
56
29
F10.2
ICD-10 Finland
Mental and behavioural disorders due to use of alcohol, Dependence syndrome
23.8
62.1
46
22
N07BB01
ATC
disulfiram; oral
9.9
61.8
80
101
3039X
ICD-9 Finland
Alcohol dependence syndrome, Other and unspecified alcohol dependence
20.1
61.2
49
28
F10.39
ICD-10 Finland
Withdrawal symptoms caused by alcohol UNS
23.6
56.7
42
20
F10.40
ICD-10 Finland
Withdrawal symptoms and delirium caused by alcohol without seizures
23.5
51.3
38
18
F10.26
ICD-10 Finland
Alcohol dependence periodic alcoholism
15.1
46.7
43
32
N05BA02
ATC
chlordiazepoxide; systemic
11.2
45.6
51
52
F10.00
ICD-10 Finland
Alcohol-related acute intoxication uncomplicated
14.7
45.0
42
32
N05CD07
ATC
temazepam; oral
5.3
41.5
103
251
N05AH04
ATC
quetiapine; oral
4.6
38.6
121
355
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
4.2
35.3
130
427
3575A
ICD-9 Finland
Inflammatory and toxic neuropathy, Alcoholic polyneuropathy
+∞
35.0
33
*
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
3.7
33.7
177
737
F32.9
ICD-10 Finland
Depressive episode, unspecified
5.2
32.6
79
186
P16
ICPC
Acute alcohol abuse
10.6
29.9
34
35
K92.0
ICD-10 Finland
Haematemesis
9.5
29.8
37
43
R56.8
ICD-10 Finland
Other and unspecified convulsions
6.3
28.4
52
94
T36
ICD-10 Finland
Poisoning by systemic antibiotics
7.8
28.2
41
58
N06AB04
ATC
citalopram; systemic
3.7
27.6
119
427
E87.1
ICD-10 Finland
Hypo-osmolality and hyponatraemia
8.0
27.3
39
54
N05BA01
ATC
diazepam; systemic, rectal
4.1
26.5
86
253
F10.09
ICD-10 Finland
Alcohol intoxication UNS
8.7
26.5
35
44
X69
ICD-10 Finland
Intentional self-poisoning by and exposure to other and unspecified chemicals and noxious substances
9.0
25.7
33
40
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
3.2
25.5
158
704
L28
ICPC
Limited function/disability (L)
3.7
25.4
100
336
A06AD11
ATC
lactulose; oral
3.8
25.3
95
309
N05CF01
ATC
zopiclone; oral
3.1
25.1
170
796
N05BA04
ATC
oxazepam; oral
3.3
24.6
132
538
N03AX12
ATC
[U] gabapentin; oral
3.6
24.1
99
341
D64.9
ICD-10 Finland
Anaemia, unspecified
4.0
23.9
80
239
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
3.8
23.7
88
283
K70.1
ICD-10 Finland
Alcoholic hepatitis
50.3
23.7
28
6
N06AX11
ATC
mirtazapine; oral
3.0
23.0
163
774
SPAT1309
SPAT
Guidance related to psychoactive substances / risk behaviour
8.4
21.6
29
37
N05AA02
ATC
levomepromazine; systemic
6.2
21.2
38
67
A28
ICPC
Limited function/disability NOS
3.3
21.0
99
369
F10.9
ICD-10 Finland
Mental and behavioural disorders due to use of alcohol, Unspecified mental and behavioural disorder
18.3
20.9
32
19
V03AA01, ,
ATC
8.3
20.7
28
36
J18.9
ICD-10 Finland
Pneumonia, unspecified
2.9
20.7
149
706
S72.0
ICD-10 Finland
Fracture of neck of femur
6.0
20.5
38
69
W19
ICD-10 Finland
Unspecified fall
4.1
19.9
62
175
J44.8
ICD-10 Finland
Other specified chronic obstructive pulmonary disease
3.4
19.8
85
298
E87.6
ICD-10 Finland
Hypokalaemia
5.9
19.7
37
68
N06AB10
ATC
escitalopram; oral
3.2
19.0
94
359
3050A
ICD-9 Finland
Nondependent abuse of drugs, Alcohol abuse
16.2
18.8
30
20
AA1AD
NOMESCO Finland
CT of head and brain
2.7
18.4
142
689
S82.8
ICD-10 Finland
Fractures of other parts of lower leg
6.7
18.3
30
48
F10.31
ICD-10 Finland
Withdrawal symptoms caused by alcohol with seizures
17.7
18.2
28
17
C03CA01
ATC
furosemide; systemic
2.7
18.1
158
814
C03DA01
ATC
spironolactone; oral
3.3
18.0
80
285
F10.30
ICD-10 Finland
Withdrawal symptoms caused by alcohol uncomplicated
14.1
17.8
30
23
N03AX16
ATC
[U] pregabalin
2.8
17.5
114
505
K70.4
ICD-10 Finland
Alcoholic hepatic failure
42.2
16.5
20
5
Z2446
NOMESCO Finland
Social worker
4.3
16.5
46
119
F10.49
ICD-10 Finland
Withdrawal symptoms and delirium caused by alcohol without information about seizures
25.9
16.2
22
9
K70.0
ICD-10 Finland
Alcoholic fatty liver
22.2
16.2
23
11
A46
ICD-10 Finland
Erysipelas
3.0
16.2
88
352
R53
ICD-10 Finland
Malaise and fatigue
2.7
16.1
112
511
S01.0
ICD-10 Finland
Open wound of scalp
3.6
15.8
57
177
XF400
NOMESCO Finland
ECG with 12 standard connections
2.9
15.7
94
396
G62.8
ICD-10 Finland
Other specified polyneuropathies
166.9
15.6
16
*
N06AB03
ATC
fluoxetine; oral
3.3
15.4
67
235
N03AF01
ATC
carbamazepine; oral, rectal
4.6
15.2
38
90
R18
ICD-10 Finland
Ascites
7.2
15.0
23
34
F10.21
ICD-10 Finland
Alcohol dependence currently abstinent, but staying in restrictive environment
14.0
14.9
25
19
S42.2
ICD-10 Finland
Fracture of upper end of humerus
5.1
14.8
32
67
R60.0
ICD-10 Finland
Localized oedema
3.3
14.5
63
220
A41.9
ICD-10 Finland
Sepsis, unspecified
5.3
14.3
30
61
N06AX16
ATC
venlafaxine; oral
3.1
13.8
65
238
JDW98
NOMESCO Finland
Other transluminal endoscopic operation on stomach or duodenum
15.5
13.8
22
15
Z72.1
ICD-10 Finland
Alcohol use
11.6
13.7
25
23
N02AX02
ATC
tramadol; systemic, rectal
2.3
13.6
195
1216
S97
ICPC
Chronic ulcer skin
3.7
13.5
46
137
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
3.2
13.5
60
212
G63.2*E11.4
ICD-10 Finland
Non-insulin-dependent diabetes mellitus - Diabetic polyneuropathy
26.9
13.5
18
7
Z3226
NOMESCO Finland
Physiotherapist
2.7
13.4
87
379
N06AA09
ATC
amitriptyline; systemic
3.5
13.2
50
160
N06AX21
ATC
duloxetine; oral
3.3
13.0
54
183
N30.0
ICD-10 Finland
Acute cystitis
3.3
13.0
53
178
NE1AA
NOMESCO Finland
Pelvis X-ray examination
3.6
12.9
45
136
F32.2
ICD-10 Finland
Severe depressive episode without psychotic symptoms
4.0
12.9
39
107
N02BF02
ATC
pregabalin; oral
4.6
12.7
31
72
EBA15
NOMESCO Finland
Extraction of multiple teeth
4.3
12.5
34
86
S22.3
ICD-10 Finland
Fracture of rib
3.3
12.5
51
171
ZXD05
NOMESCO Finland
Urgent procedure
2.3
12.2
133
733
X59
ICD-10 Finland
Exposure to unspecified factor
2.5
12.1
92
431
F33.9
ICD-10 Finland
Recurrent depressive disorder, unspecified
5.6
12.0
23
43
NA1AD
NOMESCO Finland
Cervical spine CT examination
4.4
11.8
31
76
F33.10
ICD-10 Finland
Recurrent depression, moderate episode without somatic syndrome
4.9
11.6
26
56
J44.0
ICD-10 Finland
Chronic obstructive pulmonary disease with acute lower respiratory infection
3.7
11.5
38
111
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
2.2
11.4
126
694
S82.6
ICD-10 Finland
Fracture of lateral malleolus
4.0
11.4
34
92
M79.6
ICD-10 Finland
Pain in limb
2.2
11.3
159
964
C07AA05
ATC
propranolol; systemic
2.5
11.2
82
376
K86.00
ICD-10 Finland
Acute pancreatitis caused by alcohol
9.0
11.2
23
27
Z02.7
ICD-10 Finland
Issue of medical certificate
3.6
11.2
39
118
A49.9
ICD-10 Finland
Bacterial infection, unspecified
2.7
11.1
68
286
M04AA01
ATC
allopurinol; systemic
2.5
11.1
81
372
N02BF01
ATC
gabapentin; oral
3.5
11.0
40
124
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
2.4
11.0
92
449
K70.9
ICD-10 Finland
Alcoholic liver disease, unspecified
16.1
10.9
17
11
30300
ICD-8 Finland
Alcoholism, Episodic excessive drinking
13.5
10.8
18
14
F34.1
ICD-10 Finland
Dysthymia
4.9
10.6
24
52
QDB10
NOMESCO Finland
Major dressing of wound of skin of lower limb
3.7
10.6
35
102
OAB43, ,
SPAT
0.2
10.6
8
446
N05AF03
ATC
chlorprothixene; systemic
5.7
10.5
20
37
A09AA02
ATC
multienzymes (lipase, protease etc.); oral
5.4
10.4
21
41
SPAT1254
SPAT
Administration of medicine
2.6
10.4
68
295
SPAT1265
SPAT
Breathalyser
11.1
10.4
19
18
SPAT1148
SPAT
Treatment of chronic ulcer or burn
2.6
10.4
71
315
SPAT1216
SPAT
Assessment of functional ability
2.6
10.3
70
309
N06AA12
ATC
doxepin; systemic
3.9
10.2
31
85
K92.1
ICD-10 Finland
Melaena
3.5
10.2
36
110
R4110
NOMESCO Finland
Physiotherapy
2.2
10.1
120
675
SPAT1229
SPAT
Assessment of need for aid
3.4
10.1
38
121
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
3.0
10.0
49
182
N05AB01
ATC
dixyrazine; systemic
9.1
9.9
20
23
K86.08
ICD-10 Finland
Alcohol-induced chronic pancreatitis
20.7
9.9
14
7
N17.9
ICD-10 Finland
Acute renal failure, unspecified
4.1
9.9
28
73
TKC20
NOMESCO Finland
Catheterisation of bladder
3.0
9.8
46
167
S72.1
ICD-10 Finland
Pertrochanteric fracture
5.5
9.7
19
36
SPAT1240
SPAT
Therapeutic discussion
3.2
9.7
41
140
X58
ICD-10 Finland
Exposure to other specified factors
2.5
9.6
67
299
N05AH03
ATC
olanzapine; systemic
3.5
9.6
34
104
SPAT1217
SPAT
Assessment of need for services (elderly/care support)
3.2
9.5
40
136
D50.0
ICD-10 Finland
Iron deficiency anaemia secondary to blood loss (chronic)
4.4
9.5
24
57
G63.2
ICD-10 Finland
Diabetic polyneuropathy
102.6
9.5
10
*
I85.9
ICD-10 Finland
Oesophageal varices without bleeding
12.8
9.4
16
13
N05BE01
ATC
buspirone; oral
4.7
9.4
22
49
A01
ICPC
Pain general/multiple sites
3.1
9.4
42
148
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
2.4
9.4
70
323
SPAT1230
SPAT
Aid fitting and borrowing and monitoring of use
2.4
9.2
70
325
P29
ICPC
Psychological sympt/compl other
3.9
9.2
28
77
F10.0
ICD-10 Finland
Mental and behavioural disorders due to use of alcohol, Acute intoxication
8.7
9.2
19
23
N05AD03
ATC
melperone; systemic
9.4
9.1
18
20
S06.0
ICD-10 Finland
Concussion
2.7
9.0
52
211
NH3AA
NOMESCO Finland
Foot and toes X-ray examination
3.1
9.0
39
135
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
3.0
8.9
41
147
SPAT1137
SPAT
Taking care of patient’s/customer’s hygiene
3.3
8.9
34
109
N03AX09
ATC
lamotrigine; oral
4.4
8.8
22
52
J90
ICD-10 Finland
Pleural effusion, not elsewhere classified
3.9
8.8
26
70
I70.2
ICD-10 Finland
Atherosclerosis of arteries of extremities
2.6
8.7
54
227
A02BC01
ATC
omeprazole; systemic
2.1
8.7
114
660
T50.9
ICD-10 Finland
Poisoning: Other and unspecified drugs, medicaments and biological substances
51.3
8.7
10
*
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
2.3
8.7
75
368
N05AX08
ATC
risperidone; systemic
2.9
8.7
42
155
L89
ICD-10 Finland
Decubitus ulcer and pressure area
7.2
8.7
20
29
ZXD35
NOMESCO Finland
Usual procedure
4.2
8.7
23
57
Z2221
NOMESCO Finland
Medical doctor
2.1
8.6
106
600
NH1AA
NOMESCO Finland
Ankle X-ray examination without contrast
3.4
8.6
32
101
L17
ICPC
Foot/toe symptom/complaint
2.1
8.5
110
633
F10
ICD-10 Finland
Mental and behavioural disorders due to use of alcohol
28.3
8.5
11
*
K85
ICD-10 Finland
Acute pancreatitis
7.0
8.5
20
30
A04.7
ICD-10 Finland
Enterocolitis due to Clostridium difficile
5.1
8.4
18
37
D07BC01
ATC
betamethasone and antiseptics; topical
2.6
8.4
54
231
NA3BG
NOMESCO Finland
Lumbar spine MRI examination with high intensity magnet
2.8
8.4
44
170
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
2.5
8.4
58
258
F10.03
ICD-10 Finland
Alcohol-related acute intoxication with delirium
14.9
8.3
13
9
F10.23
ICD-10 Finland
Alcohol dependence currently abstinent but using aversion-inducing or inhibitory medication
17.7
8.1
12
7
E51.2
ICD-10 Finland
Wernicke encephalopathy
34.2
8.1
10
*
IAB10
NOMESCO Finland
Psychiatric consultation concerning substance abuse
34.2
8.1
10
*
SPAT1156
SPAT
Guidance concerning treatment of rash and skin
2.4
8.0
59
270
J15.9
ICD-10 Finland
Bacterial pneumonia, unspecified
2.6
7.9
47
194
S42.0
ICD-10 Finland
Fracture of clavicle
4.4
7.8
20
48
F41.9
ICD-10 Finland
Anxiety disorder, unspecified
3.2
7.7
31
103
F10.41
ICD-10 Finland
Withdrawal symptoms and delirium caused by alcohol with seizures
18.8
7.6
11
6
L97
ICD-10 Finland
Ulcer of lower limb, not elsewhere classified
4.0
7.6
22
58
K29.2
ICD-10 Finland
Alcoholic gastritis
25.6
7.6
10
*
Z3231
NOMESCO Finland
Registered nurse
2.0
7.6
111
664
D07BA04
ATC
hydrocortisone and antiseptics; topical
2.8
7.6
39
149
E11.4
ICD-10 Finland
Type 2 diabetes mellitus, with neurological complications
4.4
7.6
19
45
K22.1
ICD-10 Finland
Ulcer of oesophagus
4.6
7.5
18
41
XF600
NOMESCO Finland
Bloodpressure measurement
3.1
7.5
32
110
P99
ICPC
Psychological disorders other
6.2
7.5
19
32
T74.1
ICD-10 Finland
Physical abuse
13.7
7.4
12
9
OAA67, ,
SPAT
0.1
7.4
*
236
E16.2
ICD-10 Finland
Hypoglycaemia, unspecified
11.2
7.4
13
12
F17.29
ICD-10 Finland
Addiction caused by tobacco UNS
6.5
7.3
18
29
K76.7
ICD-10 Finland
Hepatorenal syndrome
+∞
7.3
7
*
NF1AA
NOMESCO Finland
Hip X-ray examination
2.7
7.3
41
164
R11
ICD-10 Finland
Nausea and vomiting
2.9
7.3
35
129
GA4YT
NOMESCO Finland
Puncture of pleura with ultrasound guidance
3.9
7.2
21
56
V03AB30, ,
ATC
9.1
7.1
14
16
N03AX14
ATC
levetiracetam; systemic
4.5
7.0
17
39
S70.0
ICD-10 Finland
Contusion of hip
3.8
7.0
21
57
TPH04
NOMESCO Finland
Cathetrisation of vein
2.0
6.9
93
538
N06AB06
ATC
sertraline; oral
2.6
6.9
42
175
F05.9
ICD-10 Finland
Delirium, unspecified
6.3
6.9
17
28
K74.6
ICD-10 Finland
Other and unspecified cirrhosis of liver
6.3
6.9
17
28
K86.1
ICD-10 Finland
Other chronic pancreatitis
9.6
6.8
13
14
S43.0
ICD-10 Finland
Dislocation of shoulder joint
3.7
6.8
22
63
NHJ10
NOMESCO Finland
Internal fixation of fracture of ankle using wire, rod, cerclage or pin
3.7
6.8
22
63
I85.0
ICD-10 Finland
Oesophageal varices with bleeding
40.8
6.8
8
*
R5110, ,
SPAT
3.0
6.7
30
106
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.8
6.7
185
1341
F10.01
ICD-10 Finland
Alcohol-related acute intoxication with permanent or other somatic damage
10.3
6.6
12
12
A98
ICPC
Health maint/preventive medicine
0.5
6.5
275
3121
WX892
NOMESCO Finland
Monitored bed care
2.6
6.5
38
155
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
2.3
6.5
54
260
SPAT1222
SPAT
Counselling/guidance promoting independent living
2.2
6.5
61
309
133
Kela drug reimbursment
Severe chronic pancreatic insufficiency
6.8
6.4
15
23
7890A
ICD-9 Finland
Other symptoms involving abdomen and pelvis, Abdominal pain
3.6
6.4
21
61
R95
ICPC
Chron obstructive pulmonary disease
3.5
6.4
22
66
JA3AT
NOMESCO Finland
Cathetrisation of abdominal cavity with ultrasound guidance
6.1
6.4
16
27
G57.3
ICD-10 Finland
Lesion of lateral popliteal nerve
6.1
6.4
16
27
N07BA03
ATC
varenicline; oral
3.1
6.4
26
87
3018X
ICD-9 Finland
Personality disorders, Other personality disorders[MUU TAI SEKAMUOTOINEN PERSOONALLISUUSHÄIRIÖ]
11.3
6.3
11
10
SPAT1234
SPAT
Support of social functional capacity
3.2
6.3
25
82
J01FF01
ATC
clindamycin; systemic
1.9
6.3
105
651
NA1BG
NOMESCO Finland
Cervical spine MRI examination with high intensity magnet
3.3
6.3
23
72
F33.2
ICD-10 Finland
Recurrent depressive disorder, current episode severe without psychotic symptoms
3.7
6.2
20
57
NB1AA
NOMESCO Finland
Shoulder X-ray examination without contrast
2.8
6.2
32
122
L76
ICPC
Fracture: other
4.1
6.2
17
43
J69.0
ICD-10 Finland
Pneumonitis due to food and vomit
5.9
6.2
16
28
N05BB01
ATC
hydroxyzine; systemic
3.2
6.2
25
83
R20.2
ICD-10 Finland
Paraesthesia of skin
2.9
6.2
30
111
R42
ICD-10 Finland
Dizziness and giddiness
1.9
6.2
83
479
F10.3
ICD-10 Finland
Mental and behavioural disorders due to use of alcohol, Withdrawal state
12.8
6.1
10
8
7803A
ICD-9 Finland
General symptoms, Convulsions
12.8
6.1
10
8
K85.2
ICD-10 Finland
Alcohol-induced acute pancreatitis
12.8
6.1
10
8
SPAT1245
SPAT
Provision of support and information to patient’s family members
3.4
6.1
22
68
F32
ICD-10 Finland
Depressive episode
3.5
6.1
21
63
G40.9
ICD-10 Finland
Epilepsy, unspecified
3.5
6.1
21
63
NG4AA
NOMESCO Finland
Lower leg X-ray examination
4.0
6.1
17
44
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
133
388
4.83
43.28
3.3
2.0
2.22
1.63
%
4.80
119
334
94
296
3.94
26.29
3.2
2.2
0.19
0.21
g/l
1.52
85
277
121
504
3.10
21.30
4.8
3.7
0.72
0.82
mmol/l
12.31
111
477
75
234
3.78
20.93
1.5
2.9
65.11
66.62
g/l
0.76
68
213
124
529
3.04
20.87
1.8
1.7
1054.85
1153.22
nmol/l
0.47
98
410
80
269
3.53
19.90
4.8
2.7
27.61
35.79
u/l
1.22
75
235
101
396
3.15
19.55
6.9
6.6
1.05
1.01
mmol/l
0.50
91
374
44
106
4.59
17.27
1.3
2.0
2.83
3.07
g/l
0.63
38
94
202
1194
2.56
17.14
2.6
2.0
88.20
93.44
pmol/l
0.80
131
651
208
1270
2.49
16.12
7.1
5.4
32.66
35.22
g/l
6.85
197
1194
44
112
4.33
16.09
1.3
2.0
7.11
7.30
g/l
0.29
38
100
44
112
4.33
16.09
1.3
2.0
3.92
3.61
g/l
0.92
38
100
44
112
4.33
16.09
1.3
2.0
—
—
—
0
0
41
103
4.36
15.23
1.2
2.0
10.59
10.82
g/l
0.11
35
90
39
95
4.48
15.06
1.3
2.2
0.15
1.24
g/l
1.54
33
85
140
735
2.47
14.83
2.7
2.1
3.10
3.11
mg/l
0.01
125
640
73
275
3.07
14.82
6.5
3.8
1.65
1.77
mmol/l
0.09
67
224
38
92
4.50
14.79
1.2
1.9
35.97
37.65
g/l
0.58
32
80
205
1278
2.39
14.69
11.1
6.7
1.18
1.20
mmol/l
3.53
193
1170
160
905
2.37
14.22
3.4
2.2
396.01
292.36
u/l
0.28
154
852
32
75
4.58
12.94
1.6
1.3
—
—
—
0
0
209
1388
2.19
11.95
11.0
7.6
1.19
1.20
mmol/l
2.53
185
1184
80
357
2.59
11.63
2.0
1.8
—
—
—
0
0
131
729
2.25
11.61
1.9
1.6
17.46
20.22
nmol/l
1.39
121
619
32
82
4.18
11.55
1.7
1.5
—
—
—
0
0
102
512
2.38
11.50
2.0
1.9
—
—
—
0
0
157
944
2.17
11.43
4.1
2.6
95.76
63.84
u/l
0.50
148
887
18
14
13.46
10.76
1.1
1.0
133.28
163.46
nmol/l
0.53
18
14
160
999
2.08
10.29
2.2
2.2
68.88
73.47
nmol/l
0.92
139
879
236
2900
0.47
10.14
4.4
4.7
1.39
1.36
mmol/l
0.36
209
2668
51
195
2.88
9.93
1.9
1.6
—
—
—
0
0
77
363
2.42
9.86
2.1
1.9
—
—
—
0
0
219
1556
2.03
9.61
10.4
7.4
15.56
12.32
umol/l
1.23
211
1489
78
374
2.38
9.60
4.7
3.2
14.04
9.75
umol/l
0.69
69
334
31
89
3.72
9.57
1.6
1.6
297.79
268.92
ug/g
0.31
19
56
52
211
2.71
9.04
1.8
1.6
—
—
—
0
0
46
175
2.86
9.02
8.6
9.0
24.53
24.64
mmol/l
0.07
46
175
211
1509
1.95
8.75
12.7
15.0
1.23
1.31
inr
0.68
43
424
41
151
2.93
8.52
1.9
1.5
1.62
1.56
g/l
0.15
36
131
243
2911
0.50
8.28
4.4
4.7
4.17
4.48
mmol/l
4.38
215
2706
75
378
2.24
8.14
12.3
8.6
1.20
0.99
mmol/l
0.17
66
304
233
2824
0.51
8.10
4.0
4.2
1.41
1.35
mmol/l
0.31
201
2590
134
841
1.94
8.05
4.1
3.1
0.86
0.60
e6/l
0.32
100
639
253
2967
0.51
7.34
4.8
5.2
2.35
2.66
mmol/l
5.40
229
2733
150
1000
1.85
7.33
5.4
3.8
48.58
35.08
u/l
3.32
138
948
22
63
3.65
6.82
1.9
1.5
—
—
—
0
0
285
3203
0.49
6.78
45.8
22.5
4.14
4.55
e12/l
25.29
278
3101
285
3201
0.49
6.68
45.8
22.5
241.56
237.45
e9/l
0.37
278
3110
285
3201
0.49
6.68
47.1
22.7
37.80
40.75
%
11.59
273
2988
115
724
1.86
6.62
3.4
2.4
—
—
—
0
0
71
379
2.09
6.59
2.1
4.1
272.80
248.13
u/l
0.19
65
356
88
518
1.92
6.18
3.8
2.9
1.95
0.97
e6/l
0.43
48
301
90
540
1.89
5.95
3.7
2.7
0.92
1.03
e6/l
0.14
49
318
19
55
3.59
5.81
1.3
1.3
47.93
2066.44
e6/l
0.52
14
45
19
55
3.59
5.81
1.2
1.1
2.86
20.74
e6/l
0.75
14
43
84
506
1.86
5.44
2.9
3.4
2.46
2.45
mmol/l
0.35
69
447
210
1636
1.67
5.38
8.8
10.2
4.83
4.23
e9/l
1.90
177
1431
157
1135
1.68
5.36
3.3
2.6
285.27
181.98
ug/l
1.40
145
1040
43
205
2.25
5.27
18.3
10.7
92.81
94.44
%
0.99
43
205
183
1384
1.65
5.20
6.4
6.3
23.60
26.60
%
3.13
169
1299
154
1115
1.66
5.19
4.6
3.1
—
—
—
0
0
180
1358
1.65
5.14
6.2
6.0
61.11
57.59
%
3.00
168
1279
11
17
6.63
4.81
1.4
1.5
—
—
—
0
0
39
186
2.23
4.78
4.0
4.2
95.32
85.02
ng/l
0.35
34
167
26
104
2.62
4.66
2.0
3.3
—
1.22
—
0
12
17
54
3.25
4.54
1.9
1.4
—
—
—
0
0
17
54
3.25
4.54
1.9
1.4
—
—
—
0
0
8
9
9.06
4.30
1.0
1.0
—
—
—
0
0
7
249
0.27
4.18
1.4
1.8
—
—
—
0
0
280
3094
0.58
4.18
36.1
18.4
84.58
83.90
umol/l
0.06
280
3094
25
104
2.51
4.16
1.3
1.3
—
—
—
0
0
22
87
2.63
4.05
1.3
1.2
—
—
—
0
0
116
1550
0.63
4.02
3.3
4.3
19.28
21.08
%
0.65
46
737
38
195
2.06
3.90
2.0
1.4
—
—
—
0
0
153
1908
0.66
3.72
4.2
4.9
1.75
2.47
ug/l
1.68
138
1715
10
20
5.11
3.71
1.1
1.1
—
—
—
0
0
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
25
110
2.37
3.71
3.3
2.4
0.17
0.34
u/ml
3.59
13
61
281
3086
0.60
3.71
18.4
11.1
27.93
28.61
u/l
0.25
272
2982
124
909
1.55
3.70
3.4
3.7
2.33
2.34
mmol/l
0.25
103
800
42
229
1.94
3.65
4.4
2.6
73.38
68.84
ml/min/173m2
0.15
16
92
12
31
3.97
3.52
1.7
1.5
12875.43
25284.67
e6/l
—
7
15
27
126
2.23
3.52
1.6
3.3
—
—
—
0
0
20
82
2.52
3.44
1.6
1.4
—
—
—
0
0
18
70
2.65
3.43
1.3
1.1
—
—
—
0
0
18
70
2.65
3.43
1.3
1.1
—
—
—
0
0
231
1953
1.50
3.39
8.0
3.4
113.51
59.65
u/l
6.71
220
1825
258
2873
0.65
3.33
5.0
4.8
6.26
6.12
mmol/l
0.78
230
2618
89
620
1.58
3.27
1.7
1.7
81081580.84
7752347.13
pmol/l
0.43
74
516
214
1792
1.47
3.22
10.2
5.2
6.87
6.86
mmol/l
0.01
206
1688
20
85
2.43
3.21
3.3
3.0
1.69
1.65
mg/l
0.06
20
76
52
319
1.74
3.12
14.7
9.5
119.29
121.02
g/l
0.21
52
312
10
25
4.08
3.10
1.2
1.0
—
—
—
0
0
8
16
5.09
3.06
2.5
3.1
92.63
96.19
%
—
8
16
12
36
3.41
3.04
1.3
1.3
—
—
—
0
0
19
81
2.42
3.04
2.1
1.8
238.84
193.37
%
1.09
19
76
43
252
1.80
3.01
4.0
2.9
287.17
183.63
ng/l
0.60
36
226
10
26
3.92
3.00
1.2
1.0
—
—
—
0
0
83
1138
0.65
2.99
2.6
3.1
0.63
0.76
ug/l
1.02
58
755
39
224
1.83
2.92
4.5
3.2
2.09
1.94
mmol/l
0.09
33
165
15
58
2.65
2.91
3.2
2.8
125.67
130.40
g/l
—
9
43
15
58
2.65
2.91
3.1
2.9
15.38
16.40
%
—
9
29
257
2255
1.48
2.87
12.8
8.4
91.64
79.72
u/l
4.12
244
2115
82
580
1.53
2.80
4.6
4.0
74.15
333.07
ng/l
2.26
75
481
9
23
3.99
2.79
1.2
1.0
—
—
—
0
0
251
2784
0.68
2.78
29.8
14.2
84.55
79.17
ml/min/173m2
2.70
214
2333
7
14
5.07
2.74
1.6
1.1
—
—
—
0
0
7
14
5.07
2.74
1.6
1.1
—
—
—
0
0
7
15
4.74
2.61
1.7
1.5
—
—
—
0
0
5
7
7.22
2.55
1.2
1.3
—
—
—
0
0
(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection
6
11
5.52
2.55
1.0
1.2
—
—
—
0
0
18
82
2.26
2.52
1.4
1.5
—
—
—
0
0
9
26
3.52
2.50
1.0
1.0
—
—
—
0
0
7
16
4.44
2.48
4.1
2.4
42585.71
36919.06
ug/l
—
7
16
84
617
1.47
2.37
1.9
1.6
1.62
1.42
mg/l
0.16
65
492
283
3045
0.68
2.31
39.9
18.1
3.97
4.01
mmol/l
1.48
276
2966
253
2775
0.71
2.29
6.9
6.1
39.45
40.77
mmol/mol
1.08
236
2576
23
122
1.95
2.21
1.6
2.0
—
—
—
0
0
49
326
1.58
2.18
4.7
3.4
—
—
—
0
0
6
14
4.34
2.16
1.2
1.0
—
—
—
0
0
70
507
1.47
2.12
1.3
1.2
4.09
1.13
u/ml
0.90
18
152
11
43
2.61
2.10
1.3
2.1
—
—
—
0
0
283
3034
0.69
2.09
40.3
18.0
138.03
139.66
mmol/l
11.31
276
2953
21
111
1.95
2.05
1.4
1.8
—
—
—
0
0
5
11
4.59
1.94
1.0
1.2
—
—
—
0
0
86
1091
0.72
1.88
5.3
3.5
—
—
—
0
0
8
28
2.90
1.87
1.4
3.4
—
—
—
0
0
9
35
2.61
1.81
2.3
2.3
—
—
—
0
0
10
40
2.54
1.68
1.2
2.2
—
—
—
0
0
17
91
1.91
1.63
1.4
1.4
—
—
—
0
0
42
292
1.50
1.57
2.3
2.4
5.09
9.46
ug/l
1.35
36
262
5
15
3.36
1.53
1.4
1.0
—
—
—
0
0
158
1366
1.28
1.50
3.5
2.6
—
—
—
0
0
103
851
1.29
1.38
3.0
2.9
376.41
5812.95
umol/l
2.70
85
739
12
61
2.00
1.34
1.2
1.9
—
—
—
0
0
24
154
1.60
1.29
3.5
3.5
24.80
25.20
mmol/l
0.32
24
142
32
221
1.49
1.26
3.9
4.1
1.18
1.22
mmol/l
2.35
26
200
8
36
2.25
1.25
1.3
1.3
299.88
280.20
u/l
—
8
36
5
20
2.52
1.15
3.0
1.8
0.98
1.00
g/l
—
5
20
12
65
1.88
1.14
3.5
6.5
4.76
5.02
kpa
0.75
12
65
227
2092
1.23
1.10
4.5
4.0
20.80
12.48
mm/h
5.86
204
1932
8
41
1.97
1.09
1.3
1.6
—
—
—
0
0
113
974
1.23
1.04
2.7
3.1
2798.72
1290.54
ng/l
0.92
100
837
5
23
2.19
0.98
1.2
1.2
—
—
—
0
0
5
23
2.19
0.98
1.2
1.2
—
—
—
0
0
5
23
2.19
0.98
1.2
1.2
—
—
—
0
0
0
30
0.00
0.97
0.0
1.3
—
163.68
—
0
30
22
150
1.50
0.95
8.3
3.7
26.20
25.03
mmol/l
0.68
22
145
7
37
1.91
0.94
1.3
1.9
—
—
—
0
0
7
37
1.91
0.94
1.3
1.9
—
—
—
0
0
7
37
1.91
0.94
1.3
1.9
—
—
—
0
0
9
52
1.75
0.93
1.2
1.1
—
—
—
0
0
8
42
1.92
0.89
1.3
1.6
—
—
—
0
0
8
42
1.92
0.89
1.3
1.6
—
—
—
0
0
8
42
1.92
0.89
1.3
1.6
—
—
—
0
0
8
43
1.88
0.88
1.3
1.6
—
—
—
0
0
8
43
1.88
0.88
1.3
1.6
—
—
—
0
0
11
66
1.69
0.79
1.5
1.4
—
—
—
0
0
0
24
0.00
0.79
0.0
1.2
—
—
—
0
0
0
24
0.00
0.79
0.0
1.2
—
—
—
0
0
0
25
0.00
0.79
0.0
1.2
—
—
—
0
0
0
25
0.00
0.79
0.0
1.2
—
—
—
0
0
0
25
0.00
0.79
0.0
1.2
—
—
—
0
0
28
367
0.74
0.76
3.0
2.1
13.25
13.61
nmol/l
0.07
23
321
208
1944
1.16
0.72
3.2
3.4
14.62
14.83
pmol/l
0.59
192
1734
70
811
0.83
0.69
1.6
1.7
1.26
1.42
mmol/l
1.04
60
681
5
27
1.86
0.68
1.0
1.1
—
—
—
0
0
8
130
0.61
0.65
1.3
1.7
36.75
41.70
nmol/l
—
8
123
8
49
1.65
0.62
1.9
3.4
—
636.63
—
0
8
13
88
1.50
0.61
1.2
1.8
—
—
—
0
0
11
72
1.54
0.59
1.3
1.5
—
—
—
0
0
13
89
1.48
0.58
1.2
1.8
—
—
—
0
0
0
23
0.00
0.58
0.0
1.5
—
—
—
0
0
10
65
1.55
0.56
1.2
1.8
—
—
—
0
0
10
65
1.55
0.56
1.2
1.8
—
—
—
0
0
6
96
0.62
0.53
1.2
1.7
159.83
226.93
pmol/l
—
6
89
9
63
1.44
0.52
1.4
1.3
—
—
—
0
0
7
48
1.47
0.47
2.0
3.3
60.57
57.73
%
—
7
48
7
49
1.44
0.46
1.1
1.6
—
—
—
0
0
7
49
1.44
0.46
1.1
1.6
—
—
—
0
0
7
50
1.41
0.45
1.3
1.2
—
—
—
0
0
47
407
1.18
0.44
1.3
1.3
34.26
34.25
iu/ml
—
10
124
21
167
1.27
0.43
1.5
1.7
—
—
—
0
0
19
149
1.29
0.42
1.5
1.6
—
—
—
0
0
5
32
1.57
0.42
1.2
1.3
—
—
—
0
0
0
17
0.00
0.40
0.0
1.9
—
13.24
—
0
17
9
66
1.37
0.38
1.1
1.2
—
—
—
0
0
5
37
1.36
0.37
2.2
1.7
78.00
61.28
%
—
5
32
5
37
1.36
0.37
1.0
1.8
—
—
—
0
0
9
70
1.29
0.37
1.1
1.3
—
—
—
0
0
42
368
1.16
0.35
13.7
7.6
—
—
—
0
0
146
1382
1.09
0.34
5.6
4.6
0.00
0.00
estimate
-0.00
28
262
35
401
0.86
0.33
4.1
4.7
30.04
30.89
%
0.13
23
283
7
52
1.35
0.31
1.1
1.6
—
—
—
0
0
165
1576
1.09
0.31
2.8
2.6
—
—
—
0
0
43
382
1.14
0.31
1.4
1.3
4.70
14.65
u/ml
—
9
130
146
1390
1.08
0.29
4.2
3.4
0.00
0.00
estimate
0.50
29
275
281
2869
0.91
0.29
34.6
15.4
31.14
26.27
mg/l
1.56
257
2325
130
1234
1.08
0.28
4.8
3.9
31.45
52.63
ng/l
1.10
110
920
10
76
1.32
0.28
2.3
2.5
—
—
—
0
0
8
63
1.28
0.28
1.3
1.2
259.13
273.61
u/ml
—
8
38
147
1407
1.08
0.26
4.2
3.4
0.00
0.01
estimate
0.50
27
244
31
350
0.88
0.25
1.2
1.4
—
—
—
0
0
9
75
1.21
0.25
1.6
1.5
—
—
—
0
0
107
1017
1.07
0.22
3.9
3.8
9.20
8.53
mg/mmol
0.10
67
672
5
40
1.25
0.22
2.6
3.7
—
—
—
0
0
14
167
0.83
0.22
1.4
1.4
—
—
—
0
0
0
11
0.00
0.21
0.0
1.6
—
—
—
0
0
0
11
0.00
0.21
0.0
1.2
—
—
—
0
0
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
1.5
—
—
—
0
0
12
145
0.82
0.21
1.1
1.3
384.06
206.82
u/ml
0.54
12
130
0
12
0.00
0.21
0.0
1.2
—
—
—
0
0
0
12
0.00
0.21
0.0
1.2
—
—
—
0
0
0
12
0.00
0.21
0.0
1.2
—
—
—
0
0
0
13
0.00
0.21
0.0
1.4
—
—
—
0
0
0
13
0.00
0.21
0.0
1.1
—
—
—
0
0
0
14
0.00
0.20
0.0
1.6
—
—
—
0
0
13
109
1.20
0.19
1.1
1.0
—
—
—
0
0
256
2514
1.06
0.18
4.5
4.1
2.00
1.97
mu/l
0.17
240
2253
11
131
0.83
0.17
1.1
1.2
241.06
122.58
iu/ml
—
5
47
8
68
1.18
0.16
1.0
1.1
—
—
—
0
0
5
44
1.14
0.10
1.2
1.1
—
—
—
0
0
6
54
1.11
0.09
1.2
1.7
—
—
—
0
0
22
205
1.08
0.08
24.3
7.8
26.05
24.15
mmol/l
1.65
22
194
15
138
1.09
0.06
2.7
6.3
1.52
1.64
%
0.28
15
129
77
763
1.01
0.01
4.9
3.5
0.00
0.01
estimate
0.50
25
240
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
2.1
—
—
—
0
0
0
5
0.00
0.00
0.0
3.4
—
—
—
0
0
0
8
0.00
0.00
0.0
1.3
—
7.94
—
0
8
5
52
0.96
0.00
1.2
1.7
—
—
—
0
0
0
8
0.00
0.00
0.0
1.5
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
21.11
—
0
8
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
6
68
0.88
-0.00
1.3
1.6
—
—
—
0
0
(40770918) von Willebrand factor (vWf).activity actual/normal in Platelet poor plasma by Immunoassay
0
7
0.00
-0.00
0.0
1.1
—
133.71
—
0
7
6
61
0.98
-0.00
1.0
1.1
—
3.46
—
0
7
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
(3011547) Coagulation factor VII activity actual/normal in Platelet poor plasma by Coagulation assay
0
6
0.00
-0.00
0.0
1.2
—
111.50
—
0
6
0
7
0.00
-0.00
0.0
1.7
—
—
—
0
0
0
6
0.00
-0.00
0.0
3.5
—
101.42
—
0
6
6
59
1.02
-0.00
1.2
1.7
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.2
—
8.78
—
0
9
Mortality – FinRegistry
↥Association
Association between endpoint G6_ALCOPOLY and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_ALCOPOLY | 6.471 [5.09, 8.24] | < 0.001 |
| Birth year | 0.995 [0.99, 1.0] | 0.275 |
During the follow-up period (1.1.1998 — 31.12.2019), 255 out of 596 females with G6_ALCOPOLY died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_ALCOPOLY | 5.295 [4.65, 6.04] | < 0.001 |
| Birth year | 0.984 [0.97, 0.99] | 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 1346 out of 2491 males with G6_ALCOPOLY died.
Mortality risk
Mortality risk for people of age
years, who have G6_ALCOPOLY.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.432% | 0.871% |
| 5 | 3.556% | 5.907% |
| 10 | 9.79% | 13.436% |
| 15 | 17.855% | 24.306% |
| 20 | 29.641% | 37.061% |
Relationships between endpoints
↥Index endpoint: G6_ALCOPOLY – Alcohol induced polyneuropathy
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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