Alcohol induced polyneuropathy

G6_ALCOPOLY

alcoholic neuropathy: A condition where damage to the peripheral nervous system (including the peripheral elements of the autonomic nervous system) is associated with chronic ingestion of alcoholic beverages. The disorder may be caused by a direct effect of alcohol, an associated nutritional deficiency, or a combination of factors. Clinical manifestations include variable degrees of weakness; ATROPHY; PARESTHESIAS; pain; loss of reflexes; sensory loss; diaphoresis; and postural hypotension. (From Arch Neurol 1995;52(1):45-51; Adams et al., Principles of Neurology, 6th ed, p1146)

Suggest a new description

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 G62.1
  • Hospital discharge: ICD-9 3575A
  • Cause of death: ICD-10 G62.1
  • Cause of death: ICD-9 3575A

2 out of 7 registries used, show all original rules.

345

4. Check minimum number of events

None

345

5. Include endpoints

None

345

6. Filter based on genotype QC (FinnGen only)

345

Control definitions (FinnGen only)

Control exclude
G6_POLYNEU

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
G62
Name in latin
Polyneuropathia alcoholica

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 4609 835 3665
Only index persons 3095 628 2467
Unadjusted period prevalence (%)
Whole population 0.09 0.02 0.10
Only index persons 0.08 0.02 0.09
Median age at first event (years)
Whole population 57.12 56.02 57.32
Only index persons 57.57 57.05 57.70

-FinnGen-

Key figures

All Female Male
Number of individuals 345 68 277
Unadjusted period prevalence (%) 0.10 0.02 0.12
Median age at first event (years) 58.20 55.50 58.86

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
303
Matched controls
3030
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
G62.1
ICD-10 Finland
Alcoholic polyneuropathy
4503599627370496.0
323.0
278
*
F10.1
ICD-10 Finland
Mental and behavioural disorders due to use of alcohol, Harmful use
29.8
109.7
156
104
G62.9
ICD-10 Finland
Polyneuropathy, unspecified
107.6
86.0
91
12
G31.2
ICD-10 Finland
Degeneration of nervous system due to alcohol
124.2
57.2
60
6
F10.25
ICD-10 Finland
Alcohol dependence continuous use
42.6
54.2
67
20
F10.20
ICD-10 Finland
Alcohol dependence currently independent
30.9
50.8
68
28
F10.29
ICD-10 Finland
Addiction caused by alcohol UNS
24.0
47.2
68
36
K70.3
ICD-10 Finland
Alcoholic cirrhosis of liver
35.5
45.1
58
20
F10.24
ICD-10 Finland
Alcohol depence active use
42.6
35.8
44
12
P15
ICPC
Chronic alcohol abuse
18.5
34.6
54
35
N07BB01
ATC
disulfiram; oral
10.8
30.5
61
69
3575A
ICD-9 Finland
Inflammatory and toxic neuropathy, Alcoholic polyneuropathy
+∞
29.7
28
*
3039X
ICD-9 Finland
Alcohol dependence syndrome, Other and unspecified alcohol dependence
19.1
28.1
43
26
N05CD07
ATC
temazepam; oral
5.6
27.3
90
213
N05BA02
ATC
chlordiazepoxide; systemic
13.4
25.5
45
39
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
3.9
25.2
139
542
N05AH04
ATC
quetiapine; oral
5.1
25.2
91
236
F10.2
ICD-10 Finland
Mental and behavioural disorders due to use of alcohol, Dependence syndrome
24.6
25.0
35
16
F10.39
ICD-10 Finland
Withdrawal symptoms caused by alcohol UNS
23.8
24.1
34
16
F10.26
ICD-10 Finland
Alcohol dependence periodic alcoholism
15.4
22.5
37
27
F10.9
ICD-10 Finland
Mental and behavioural disorders due to use of alcohol, Unspecified mental and behavioural disorder
31.9
22.3
29
10
F10.00
ICD-10 Finland
Alcohol-related acute intoxication uncomplicated
17.0
22.1
35
23
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
4.4
22.1
93
278
R56.8
ICD-10 Finland
Other and unspecified convulsions
9.2
22.0
47
59
F10.40
ICD-10 Finland
Withdrawal symptoms and delirium caused by alcohol without seizures
18.4
21.5
33
20
F32.9
ICD-10 Finland
Depressive episode, unspecified
5.8
21.2
64
133
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
3.5
20.9
131
547
N05CF01
ATC
zopiclone; oral
3.3
20.5
139
612
F10.31
ICD-10 Finland
Withdrawal symptoms caused by alcohol with seizures
33.9
19.6
25
8
N06AX11
ATC
mirtazapine; oral
3.3
19.5
127
538
N06AB04
ATC
citalopram; systemic
3.7
19.1
98
343
N05BA04
ATC
oxazepam; oral
3.5
18.7
107
409
J18.9
ICD-10 Finland
Pneumonia, unspecified
3.3
18.6
120
500
K70.1
ICD-10 Finland
Alcoholic hepatitis
27.1
18.5
25
10
3050A
ICD-9 Finland
Nondependent abuse of drugs, Alcohol abuse
21.7
18.1
26
13
N03AX12
ATC
gabapentin; oral
4.3
18.1
73
206
F10.09
ICD-10 Finland
Alcohol intoxication UNS
13.1
17.8
31
26
AA1AD
NOMESCO Finland
CT of head and brain
3.3
17.3
109
442
C03DA01
ATC
spironolactone; oral
4.6
16.9
63
163
A06AD11
ATC
lactulose; oral
3.7
16.4
82
278
T36
ICD-10 Finland
Poisoning by systemic antibiotics
8.8
15.8
34
43
J44.8
ICD-10 Finland
Other specified chronic obstructive pulmonary disease
3.9
15.6
71
221
N05AA02
ATC
levomepromazine; systemic
7.5
15.6
37
55
C03CA01
ATC
furosemide; systemic
2.9
15.4
124
586
R53
ICD-10 Finland
Malaise and fatigue
3.3
14.9
85
316
E87.6
ICD-10 Finland
Hypokalaemia
10.9
14.8
28
28
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
3.7
14.7
70
226
K70.4
ICD-10 Finland
Alcoholic hepatic failure
38.1
14.6
18
5
P16
ICPC
Acute alcohol abuse
13.6
14.2
24
19
F10.30
ICD-10 Finland
Withdrawal symptoms caused by alcohol uncomplicated
18.7
14.0
21
12
A28
ICPC
Limited function/disability NOS
3.5
14.0
74
257
L28
ICPC
Limited function/disability (L)
3.4
13.6
73
257
F10.49
ICD-10 Finland
Withdrawal symptoms and delirium caused by alcohol without information about seizures
22.4
13.5
19
9
D64.9
ICD-10 Finland
Anaemia, unspecified
3.8
13.5
61
188
K86.00
ICD-10 Finland
Acute pancreatitis caused by alcohol
13.9
13.1
22
17
K70.0
ICD-10 Finland
Alcoholic fatty liver
29.9
13.1
17
6
W19
ICD-10 Finland
Unspecified fall
4.3
13.1
51
137
K70.9
ICD-10 Finland
Alcoholic liver disease, unspecified
52.4
13.0
15
*
K92.0
ICD-10 Finland
Haematemesis
7.6
12.9
30
43
N05BA01
ATC
diazepam; systemic, rectal
3.5
12.9
67
230
X69
ICD-10 Finland
Intentional self-poisoning by and exposure to other and unspecified chemicals and noxious substances
8.9
12.9
27
33
F10.21
ICD-10 Finland
Alcohol dependence currently abstinent, but staying in restrictive environment
18.3
12.7
19
11
Z72.1
ICD-10 Finland
Alcohol use
21.2
12.6
18
9
G62.8
ICD-10 Finland
Other specified polyneuropathies
135.4
12.5
13
*
G63.2*E11.4
ICD-10 Finland
Non-insulin-dependent diabetes mellitus - Diabetic polyneuropathy
135.4
12.5
13
*
S72.0
ICD-10 Finland
Fracture of neck of femur
6.6
12.5
32
53
XF400
NOMESCO Finland
ECG with 12 standard connections
3.0
12.0
78
313
A46
ICD-10 Finland
Erysipelas
3.1
11.9
71
269
N06AB03
ATC
fluoxetine; oral
3.8
11.8
53
162
N06AB10
ATC
escitalopram; oral
3.0
11.6
74
291
S42.2
ICD-10 Finland
Fracture of upper end of humerus
7.6
11.3
26
37
N03AF01
ATC
carbamazepine; oral, rectal
5.3
11.1
34
71
JDW98
NOMESCO Finland
Other transluminal endoscopic operation on stomach or duodenum
12.6
11.0
19
16
A49.9
ICD-10 Finland
Bacterial infection, unspecified
3.4
11.0
56
189
V03AA01
ATC
NA
9.0
10.7
22
26
K85
ICD-10 Finland
Acute pancreatitis
11.8
10.7
19
17
E87.1
ICD-10 Finland
Hypo-osmolality and hyponatraemia
6.2
10.6
28
49
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
2.5
10.5
96
467
S01.0
ICD-10 Finland
Open wound of scalp
4.0
10.5
42
116
N03AX16
ATC
pregabalin; oral
2.5
10.4
94
456
SPAT1265
SPAT
Breathalyser
19.6
10.4
15
8
N02AX02
ATC
tramadol; systemic, rectal
2.2
10.3
159
1003
N05AB01
ATC
dixyrazine; systemic
11.9
10.2
18
16
N06AA09
ATC
amitriptyline; systemic
3.7
10.0
44
132
S22.3
ICD-10 Finland
Fracture of rib
3.9
9.5
39
110
X59
ICD-10 Finland
Exposure to unspecified factor
2.7
9.2
71
312
R18
ICD-10 Finland
Ascites
8.7
9.2
19
23
L89
ICD-10 Finland
Decubitus ulcer and pressure area
12.0
9.2
16
14
SPAT1309
SPAT
Guidance related to psychoactive substances / risk behaviour
6.9
9.1
22
34
SPAT1217
SPAT
Assessment of need for services (elderly/care support)
4.1
9.1
35
93
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
3.7
9.1
40
120
EBA15
NOMESCO Finland
Extraction of large number of teeth
4.7
9.0
30
69
K86.08
ICD-10 Finland
Alcohol-induced chronic pancreatitis
24.9
9.0
12
5
N05AD03
ATC
melperone; systemic
13.1
9.0
15
12
N06AX16
ATC
venlafaxine; oral
3.2
8.9
49
172
R60.0
ICD-10 Finland
Localized oedema
3.2
8.9
47
163
F32.2
ICD-10 Finland
Severe depressive episode without psychotic symptoms
4.3
8.8
32
81
QDB10
NOMESCO Finland
Major dressing of wound of skin of lower limb
5.0
8.7
27
58
A02BC01
ATC
omeprazole; systemic
2.3
8.7
97
518
F34.1
ICD-10 Finland
Dysthymia
6.3
8.6
22
37
IAB10
NOMESCO Finland
Psychiatric consultation concerning substance abuse
+∞
8.4
8
*
C07AA05
ATC
propranolol; systemic
2.6
8.3
63
274
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
3.1
8.3
47
171
TKC20
NOMESCO Finland
Catheterisation of bladder
3.3
8.2
42
142
N05BE01
ATC
buspirone; oral
6.9
8.0
19
29
S82.8
ICD-10 Finland
Fractures of other parts of lower leg
5.3
7.9
23
46
NE1AA
NOMESCO Finland
Pelvis X-ray examination
3.7
7.8
33
96
G63.2
ICD-10 Finland
Diabetic polyneuropathy
46.2
7.8
9
*
F10.23
ICD-10 Finland
Alcohol dependence currently abstinent but using aversion-inducing or inhibitory medication
46.2
7.8
9
*
T50.9
ICD-10 Finland
Poisoning: Other and unspecified drugs, medicaments and biological substances
46.2
7.8
9
*
N02AA05
ATC
oxycodone; systemic
2.6
7.7
57
244
Z02.7
ICD-10 Finland
Issue of medical certificate
3.8
7.7
32
92
V03AB30
ATC
NA
19.0
7.7
11
6
R4110
NOMESCO Finland
Physiotherapy
2.2
7.6
92
502
M04AA01
ATC
allopurinol; systemic
2.5
7.5
61
276
F10
ICD-10 Finland
Mental and behavioural disorders due to use of alcohol
82.0
7.4
8
*
A09AA02
ATC
multienzymes (lipase, protease etc.)
8.7
7.4
15
18
F10.0
ICD-10 Finland
Mental and behavioural disorders due to use of alcohol, Acute intoxication
9.7
7.4
14
15
S06.0
ICD-10 Finland
Concussion
3.0
7.3
43
160
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
2.4
7.3
65
307
K29.2
ICD-10 Finland
Alcoholic gastritis
+∞
7.3
7
*
G72.8
ICD-10 Finland
Other specified myopathies
16.2
7.3
11
7
N06AX21
ATC
duloxetine; oral
3.1
7.3
40
140
N05AF03
ATC
chlorprothixene; systemic
6.3
7.2
18
30
3018X
ICD-9 Finland
Personality disorders, Other personality disorders[MUU TAI SEKAMUOTOINEN PERSOONALLISUUSHÄIRIÖ]
20.6
7.2
10
5
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
2.6
7.2
54
233
SPAT1216
SPAT
Assessment of functional ability
2.6
7.1
56
247
A02BC02
ATC
pantoprazole; systemic
1.9
7.0
197
1483
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
3.0
7.0
40
146
SPAT1148
SPAT
Treatment of chronic ulcer or burn
2.5
7.0
56
251
X58
ICD-10 Finland
Exposure to other specified factors
2.6
7.0
53
230
E11.4
ICD-10 Finland
Type 2 diabetes mellitus, with neurological complications
7.0
6.9
16
24
NA1AD
NOMESCO Finland
Cervical spine CT examination
4.9
6.9
21
45
M79.6
ICD-10 Finland
Pain in limb
2.0
6.8
109
663
J44.0
ICD-10 Finland
Chronic obstructive pulmonary disease with acute lower respiratory infection
3.9
6.8
27
75
F10.41
ICD-10 Finland
Withdrawal symptoms and delirium caused by alcohol with seizures
41.0
6.8
8
*
F33.10
ICD-10 Finland
Recurrent depression, moderate episode without somatic syndrome
5.0
6.7
20
42
J15.9
ICD-10 Finland
Bacterial pneumonia, unspecified
3.1
6.7
37
131
JDB10
NOMESCO Finland
Percutaneous gastrostomy
12.6
6.6
11
9
N06AB06
ATC
sertraline; oral
3.2
6.6
34
116
N30.0
ICD-10 Finland
Acute cystitis
3.0
6.6
37
133
SPAT1230
SPAT
Aid fitting and borrowing and monitoring of use
2.4
6.5
60
287
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
3.1
6.5
34
118
R27.0
ICD-10 Finland
Ataxia, unspecified
71.3
6.4
7
*
SPAT1240
SPAT
Therapeutic discussion
3.3
6.4
31
101
F61.0
ICD-10 Finland
Mixed personality disorders
11.4
6.3
11
10
E16.2
ICD-10 Finland
Hypoglycaemia, unspecified
11.4
6.3
11
10
E950A
ICD-9 Finland
Suicide and self-inflicted poisoning by solid or liquid substances
11.4
6.3
11
10
K86.1
ICD-10 Finland
Other chronic pancreatitis
11.4
6.3
11
10
3018D
ICD-9 Finland
Personality disorders, Other personality disorders[EPÄVAKAA PERSOONALLISUUS]
18.5
6.3
9
5
J44.9
ICD-10 Finland
Chronic obstructive pulmonary disease, unspecified
3.5
6.3
28
86
N05AX08
ATC
risperidone; systemic
3.2
6.3
32
109
S92
ICD-10 Finland
Fracture of foot, except ankle
+∞
6.3
6
*
E51.2
ICD-10 Finland
Wernicke encephalopathy
27.3
6.3
8
*
S82.6
ICD-10 Finland
Fracture of lateral malleolus
3.6
6.2
27
81
N03AX14
ATC
levetiracetam; systemic
7.9
6.2
13
17
NH1AA
NOMESCO Finland
Ankle X-ray examination without contrast
3.7
6.2
25
71
SPAT1137
SPAT
Taking care of patient’s/customer’s hygiene
3.7
6.2
25
71
A41.9
ICD-10 Finland
Sepsis, unspecified
4.6
6.2
20
46
N39.0
ICD-10 Finland
Urinary tract infection, site not specified
2.7
6.2
42
170
S82.2
ICD-10 Finland
Fracture of shaft of tibia
12.9
6.1
10
8
I85.9
ICD-10 Finland
Oesophageal varices without bleeding
8.9
6.1
12
14
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
2.2
6.1
62
313
F41.9
ICD-10 Finland
Anxiety disorder, unspecified
3.8
6.1
24
67
N06AA12
ATC
doxepin; systemic
3.9
6.0
23
62
SPAT1254
SPAT
Administration of medicine
2.4
6.0
52
239

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
83
276
3.64
21.18
3.2
2.2
0.2
0.2
g/l
1.31
75
257
113
466
3.12
20.27
4.9
3.6
0.7
0.8
mmol/l
10.89
103
439
61
176
4.00
19.01
1.5
2.5
—
—
—
0
0
116
511
2.91
18.23
1.8
1.7
1094.9
1145.5
nmol/l
0.20
92
395
68
221
3.59
17.77
1.6
2.9
65.4
66.7
g/l
0.61
62
201
93
368
3.09
17.65
7.2
6.2
1.0
1.0
mmol/l
0.59
83
347
73
254
3.38
17.12
5.0
2.7
26.4
36.2
u/l
1.52
68
220
196
1202
2.46
14.93
7.1
5.3
32.8
35.2
g/l
6.31
185
1127
16
15
11.14
14.75
1.1
1.0
137.9
160.1
nmol/l
0.33
16
15
66
237
3.21
14.58
13.5
9.3
—
—
—
0
0
68
249
3.16
14.53
6.8
3.9
1.7
1.8
mmol/l
0.12
61
193
70
261
3.11
14.51
6.6
4.0
—
—
—
0
0
185
1128
2.38
13.98
2.6
2.0
89.8
93.8
pmol/l
0.51
118
615
142
772
2.43
13.91
5.2
4.4
7.4
7.4
ph
0.14
23
146
131
692
2.44
13.63
2.7
2.0
3.2
3.1
mg/l
0.02
117
602
193
1217
2.33
13.25
11.3
6.5
1.2
1.2
mmol/l
3.69
181
1103
35
88
4.31
12.98
1.3
1.9
36.3
37.4
g/l
0.35
30
73
92
443
2.47
11.45
2.7
2.0
—
—
—
0
0
79
354
2.60
11.44
2.3
1.6
—
—
—
0
0
198
1317
2.18
11.26
11.1
7.4
1.2
1.2
mmol/l
2.55
175
1114
43
1030
0.33
10.91
3.2
3.0
—
—
—
0
0
149
896
2.17
10.87
4.1
2.6
98.0
58.2
u/l
0.63
140
842
220
2746
0.45
10.73
4.5
4.7
1.4
1.4
mmol/l
0.22
195
2526
63
261
2.73
10.61
1.9
1.6
—
—
—
0
0
80
388
2.38
9.66
15.4
7.3
103.4
104.0
mmol/l
0.44
80
379
117
667
2.14
9.55
6.4
7.4
—
—
—
0
0
82
412
2.30
9.08
11.8
23.5
1.1
1.3
inr
—
6
50
29
85
3.63
8.70
1.7
1.6
298.4
271.1
ug/g
0.27
18
52
227
2754
0.49
8.66
4.4
4.7
4.1
4.5
mmol/l
6.66
201
2559
218
2680
0.49
8.64
4.1
4.2
1.4
1.3
mmol/l
0.42
189
2458
117
692
2.05
8.50
1.8
1.6
18.3
20.4
nmol/l
0.82
109
585
72
353
2.31
8.40
4.9
3.2
13.1
10.0
umol/l
0.41
63
314
144
926
1.95
8.18
5.2
5.8
—
—
—
0
0
204
1477
1.93
8.08
10.4
7.2
15.5
12.3
umol/l
1.09
196
1411
38
139
2.95
8.01
2.0
1.5
1.7
1.5
g/l
0.27
33
121
42
163
2.80
7.95
8.6
8.0
24.4
24.7
mmol/l
0.19
42
163
71
355
2.26
7.88
12.4
8.3
1.2
1.0
mmol/l
0.19
61
282
60
279
2.39
7.87
2.0
1.5
—
—
—
0
0
136
869
1.93
7.79
7.9
4.3
—
—
—
0
0
237
2805
0.50
7.49
4.8
5.2
2.3
2.7
mmol/l
7.19
215
2583
139
908
1.89
7.35
3.7
2.4
—
—
—
0
0
267
3033
0.47
7.30
46.4
22.3
4.1
4.5
e12/l
23.15
262
2936
267
3033
0.47
7.30
46.4
22.4
7.5
6.9
e9/l
4.86
262
2934
267
3031
0.47
7.20
46.4
22.3
241.5
236.9
e9/l
0.42
262
2943
14
27
5.36
7.03
1.3
1.2
—
—
—
0
0
124
796
1.87
6.82
4.2
3.1
0.8
0.6
e6/l
0.24
91
601
65
334
2.17
6.69
1.9
1.6
—
—
—
0
0
112
702
1.88
6.60
4.0
2.9
—
—
—
0
0
13
25
5.36
6.54
1.6
1.7
—
—
—
0
0
40
169
2.55
6.41
1.6
1.5
—
—
—
0
0
69
371
2.07
6.30
1.7
1.3
—
—
—
0
0
19
52
3.81
6.29
1.3
1.3
47.9
2162.3
e6/l
0.52
14
43
19
52
3.81
6.29
1.2
1.2
2.9
21.2
e6/l
0.75
14
42
94
565
1.91
6.26
2.9
2.7
464.3
594.4
mosm/kgh2o
6.23
81
478
117
759
1.82
6.11
4.3
3.1
—
—
—
0
0
10
16
6.41
5.99
1.1
1.1
—
—
—
0
0
80
463
1.95
5.93
2.8
2.3
10.9
13.1
umol/l
1.80
75
433
96
592
1.86
5.86
2.8
2.5
5.9
3.7
e6/l
1.09
81
515
10
9
11.40
5.83
1.4
1.6
—
—
—
0
0
17
46
3.84
5.71
1.4
1.1
—
—
—
0
0
17
46
3.84
5.71
1.2
1.1
—
—
—
0
0
129
878
1.75
5.64
4.4
3.2
23.1
138.0
e6/l
0.94
97
690
65
359
2.00
5.48
2.5
2.5
2.0
1.9
%
0.30
57
331
41
190
2.31
5.39
18.3
10.1
92.8
94.4
%
0.85
41
190
167
1232
1.69
5.38
9.7
9.0
1.2
1.3
inr
0.48
35
341
11
22
5.13
5.29
2.3
1.5
—
—
—
0
0
80
482
1.86
5.20
2.8
3.3
2.5
2.4
mmol/l
0.24
65
424
179
1355
1.67
5.15
5.8
5.9
0.0
0.0
e9/l
0.01
147
1166
167
1244
1.66
5.10
6.1
6.0
0.7
0.7
%
0.03
155
1156
139
988
1.68
5.08
5.0
3.7
129.6
63.8
e6/l
0.71
98
735
178
1349
1.66
5.07
5.9
5.9
0.6
0.6
e9/l
0.44
144
1153
169
1270
1.65
4.94
6.1
6.1
2.5
2.9
%
2.21
158
1179
180
1376
1.64
4.90
5.9
5.9
1.7
2.0
e9/l
0.92
149
1207
0
122
0.00
4.82
0.0
1.7
—
—
—
0
0
37
173
2.28
4.77
4.1
4.2
98.3
86.5
ng/l
0.39
32
155
169
1281
1.63
4.69
6.5
6.4
8.9
8.9
%
0.01
158
1193
171
1306
1.61
4.57
6.2
6.2
23.8
26.6
%
2.56
158
1210
262
2925
0.57
4.56
36.6
18.2
85.4
83.8
umol/l
0.15
262
2925
168
1280
1.61
4.51
6.1
6.0
61.2
57.6
%
2.81
157
1198
13
35
3.82
4.40
2.6
1.5
—
—
—
0
0
19
66
2.99
4.40
1.4
1.5
—
—
—
0
0
20
72
2.89
4.36
1.5
1.3
—
—
—
0
0
179
1393
1.59
4.35
6.5
6.2
0.2
0.2
e9/l
0.92
150
1226
16
51
3.24
4.26
1.4
1.1
—
—
—
0
0
263
2922
0.58
4.21
18.4
11.0
27.4
28.5
u/l
0.45
254
2819
194
1546
1.58
4.20
8.8
10.1
4.9
4.2
e9/l
2.18
166
1350
55
315
1.89
4.15
1.4
1.3
581.8
439.4
titre
0.43
11
71
144
1074
1.58
4.13
3.4
2.5
267.4
182.6
ug/l
0.98
133
984
17
58
3.03
4.07
5.4
2.9
—
—
—
0
0
12
33
3.73
3.95
1.6
2.0
—
—
—
0
0
14
43
3.35
3.95
1.0
1.2
—
—
—
0
0
73
1080
0.59
3.92
2.7
3.1
0.6
0.8
ug/l
1.26
51
721
42
224
2.00
3.89
1.8
2.0
12.4
10.7
g/l
1.42
37
204
142
1798
0.64
3.88
4.1
4.9
1.7
2.5
ug/l
2.07
130
1613
22
90
2.54
3.80
5.5
3.4
—
—
—
0
0
16
55
3.00
3.79
1.7
1.6
—
—
—
0
0
6
5
12.18
3.77
2.0
1.0
—
—
—
0
0
18
67
2.78
3.72
1.3
1.1
—
—
—
0
0
256
2844
0.61
3.66
28.9
14.4
—
—
—
0
0
72
467
1.68
3.56
1.7
1.3
3.8
2.9
g/l
2.18
51
290
117
858
1.55
3.50
3.4
3.6
2.3
2.3
mmol/l
0.30
97
749
242
2716
0.63
3.49
5.0
4.8
6.3
6.1
mmol/l
1.00
217
2474
14
47
3.06
3.45
1.7
1.4
—
—
—
0
0
87
600
1.60
3.38
3.5
3.4
—
—
—
0
0
16
59
2.80
3.37
1.5
1.2
—
—
—
0
0
27
129
2.19
3.34
8.3
2.5
0.6
0.7
%
0.38
27
124
41
236
1.84
3.05
4.1
3.0
280.3
181.5
ng/l
0.53
34
213
14
51
2.82
3.02
3.3
2.6
15.7
16.3
%
—
8
24
9
21
4.37
3.01
1.2
1.1
—
—
—
0
0
0
78
0.00
2.99
0.0
1.6
—
—
—
0
0
14
53
2.71
2.83
3.4
2.7
128.3
130.3
g/l
—
8
38
14
53
2.71
2.83
4.1
4.6
—
—
—
0
0
83
592
1.53
2.74
1.7
1.7
85714783.1
8130484.1
pmol/l
0.43
70
492
265
2884
0.65
2.74
40.5
18.0
4.0
4.0
mmol/l
0.87
258
2808
78
550
1.54
2.71
4.7
4.0
78.6
349.3
ng/l
2.23
70
456
16
67
2.46
2.67
2.4
4.0
—
—
—
0
0
236
2623
0.68
2.66
7.0
6.2
39.7
40.7
mmol/mol
0.70
220
2434
18
80
2.32
2.65
3.5
2.5
1.7
1.6
mg/l
0.19
18
72
44
271
1.71
2.63
2.2
2.7
83.3
73.9
e9/l
0.47
28
215
9
26
3.53
2.50
1.9
1.5
—
—
—
0
0
265
2872
0.67
2.48
41.0
17.9
138.0
139.7
mmol/l
11.17
258
2794
199
1699
1.40
2.47
10.5
5.1
6.9
6.9
mmol/l
0.09
191
1600
6
12
5.07
2.41
3.0
2.1
—
—
—
0
0
7
17
4.18
2.37
1.6
2.6
—
—
—
0
0
5
156
0.31
2.34
1.0
1.3
—
—
—
0
0
30
171
1.83
2.33
14.3
10.9
—
—
—
0
0
6
13
4.68
2.28
1.5
1.1
—
—
—
0
0
240
2138
1.40
2.19
12.8
8.2
91.8
79.8
u/l
3.90
228
2002
26
145
1.86
2.17
1.3
1.2
—
—
—
0
0
36
224
1.68
2.10
4.6
3.1
7.4
7.4
ph
—
7
18
12
50
2.45
2.05
6.2
2.3
61.2
65.4
%
0.26
12
50
12
50
2.45
2.05
2.3
1.3
—
—
—
0
0
6
15
4.05
2.04
1.7
1.7
—
—
—
0
0
52
357
1.54
2.04
1.3
1.5
—
—
—
0
0
12
51
2.40
1.97
2.3
1.3
—
—
—
0
0
53
737
0.67
1.96
4.5
3.1
—
—
—
0
0
54
747
0.67
1.95
1.4
1.4
—
—
—
0
0
12
52
2.35
1.90
2.3
1.3
—
—
—
0
0
12
52
2.35
1.90
2.3
1.3
—
—
—
0
0
221
2437
0.74
1.88
37.4
16.5
37.0
40.3
%
6.25
151
1710
143
1200
1.33
1.80
11.4
9.9
0.0
0.0
e9/l
0.42
115
978
77
588
1.40
1.77
1.9
1.6
1.2
1.4
mg/l
0.64
61
472
5
13
3.89
1.72
1.0
1.5
—
—
—
0
0
40
272
1.53
1.66
2.4
2.4
5.1
9.7
ug/l
1.31
34
242
208
1854
1.31
1.64
5.0
4.0
—
—
—
0
0
64
480
1.41
1.63
1.3
1.2
4.3
1.1
u/ml
0.96
17
143
10
43
2.37
1.61
2.2
1.3
—
—
—
0
0
11
51
2.19
1.52
2.5
1.3
—
—
—
0
0
12
58
2.11
1.51
6.7
2.4
—
—
—
0
0
5
16
3.15
1.44
1.4
1.0
—
—
—
0
0
7
29
2.44
1.40
1.3
1.0
—
—
—
0
0
25
160
1.61
1.36
1.2
1.2
—
—
—
0
0
6
24
2.53
1.31
1.3
3.7
—
—
—
0
0
148
1290
1.26
1.29
4.9
4.0
—
—
—
0
0
8
35
2.32
1.27
5.4
3.4
—
—
—
0
0
5
19
2.65
1.22
3.0
1.4
1.0
1.0
g/l
—
5
19
6
126
0.47
1.19
1.0
1.2
—
—
—
0
0
6
26
2.33
1.19
6.3
3.3
—
—
—
0
0
30
208
1.48
1.17
4.0
3.6
1.2
1.2
mmol/l
2.20
25
188
96
804
1.27
1.16
2.9
2.8
384.2
6168.1
umol/l
2.69
79
694
5
20
2.52
1.15
1.4
1.2
—
—
—
0
0
37
269
1.42
1.14
4.6
4.3
—
—
—
0
0
7
30
2.36
1.13
1.6
1.2
—
—
—
0
0
26
177
1.51
1.11
4.3
3.1
—
—
—
0
0
21
136
1.58
1.11
8.6
3.8
26.4
24.9
mmol/l
0.91
21
131
5
21
2.40
1.09
2.4
1.3
—
—
—
0
0
11
60
1.86
1.04
3.7
5.9
7.6
8.3
kpa
1.16
11
60
11
60
1.86
1.04
3.7
5.9
4.7
5.0
kpa
0.74
11
60
17
108
1.60
0.98
23.0
4.4
—
—
—
0
0
29
208
1.43
0.98
9.8
5.1
—
—
—
0
0
0
30
0.00
0.97
0.0
1.3
—
65.8
—
0
10
9
50
1.82
0.97
1.7
3.3
—
—
—
0
0
25
344
0.71
0.90
3.0
2.1
14.2
13.7
nmol/l
0.09
20
303
17
111
1.56
0.89
1.5
1.6
—
—
—
0
0
31
230
1.38
0.88
3.4
4.4
0.1
0.2
%
0.31
12
79
8
44
1.84
0.86
1.5
1.3
—
—
—
0
0
21
146
1.47
0.84
3.5
3.5
25.0
25.3
mmol/l
0.25
21
135
12
73
1.67
0.82
1.2
1.3
—
3.6
—
0
5
6
32
1.89
0.82
1.3
1.8
87.3
89.8
%
—
6
32
29
216
1.37
0.82
3.2
4.4
0.7
0.4
%
0.77
12
64
64
759
0.81
0.80
1.5
1.7
1.3
1.4
mmol/l
0.92
56
636
17
115
1.50
0.78
1.3
1.4
—
—
—
0
0
13
83
1.59
0.76
1.8
1.7
—
—
—
0
0
105
927
1.19
0.76
3.3
3.1
6.6
8.3
mmol/l
3.85
84
763
186
1996
0.85
0.76
4.3
4.1
—
—
—
0
0
23
310
0.72
0.75
1.5
1.5
—
—
—
0
0
5
24
2.10
0.75
1.4
1.3
—
—
—
0
0
5
25
2.01
0.73
1.4
1.2
—
—
—
0
0
9
57
1.59
0.71
1.4
2.0
—
—
—
0
0
32
249
1.31
0.70
3.3
4.3
1.2
0.9
%
0.36
13
89
101
896
1.18
0.69
3.4
3.3
698.3
200.6
mg/l
0.36
70
613
211
1988
1.16
0.65
4.6
4.1
20.7
12.6
mm/h
5.49
190
1832
5
30
1.68
0.61
1.6
1.4
—
—
—
0
0
197
1852
1.15
0.61
3.2
3.4
14.6
14.9
pmol/l
0.63
182
1651
0
20
0.00
0.60
0.0
4.8
—
—
—
0
0
0
21
0.00
0.60
0.0
1.1
—
6.0
—
0
5
0
22
0.00
0.59
0.0
1.2
—
—
—
0
0
0
22
0.00
0.59
0.0
1.2
—
—
—
0
0
0
22
0.00
0.59
0.0
1.0
—
0.4
—
0
5
27
212
1.30
0.57
3.6
4.6
3.2
0.1
%
0.45
12
69
79
887
0.86
0.55
4.7
4.1
—
—
—
0
0
28
224
1.27
0.53
3.8
3.3
—
—
—
0
0
9
64
1.42
0.52
1.7
1.5
—
—
—
0
0
6
40
1.51
0.52
1.0
1.2
—
—
—
0
0
263
2715
0.87
0.49
35.2
15.3
30.8
26.2
mg/l
1.48
242
2203
7
45
1.57
0.49
2.0
3.0
60.6
57.5
%
—
7
45
7
46
1.53
0.48
1.1
1.6
—
—
—
0
0
7
46
1.53
0.48
1.1
1.6
—
—
—
0
0
7
46
1.53
0.48
1.1
1.6
—
—
—
0
0
7
46
1.53
0.48
1.1
1.6
—
—
—
0
0
7
47
1.50
0.48
1.1
4.7
—
—
—
0
0
45
386
1.19
0.46
1.3
1.3
40.3
36.1
iu/ml
—
8
122
8
121
0.65
0.46
1.3
1.6
36.8
42.5
nmol/l
—
8
115
5
84
0.59
0.46
7.6
3.9
—
—
—
0
0
27
220
1.25
0.45
5.8
3.3
—
—
—
0
0
16
121
1.34
0.45
1.3
1.2
—
—
—
0
0
6
92
0.65
0.43
3.7
8.5
1.7
1.4
mmol/l
—
6
80
0
15
0.00
0.41
0.0
1.0
—
—
—
0
0
0
15
0.00
0.41
0.0
1.3
—
—
—
0
0
0
17
0.00
0.40
0.0
1.6
—
—
—
0
0
10
137
0.72
0.40
1.1
1.3
288.7
206.0
u/ml
—
10
123
8
61
1.32
0.40
1.3
1.2
259.1
271.5
u/ml
—
8
37
9
68
1.33
0.38
1.2
1.1
—
—
—
0
0
28
236
1.20
0.36
1.3
1.4
—
—
—
0
0
6
42
1.44
0.35
1.8
2.9
4.4
5.0
e9/l
—
6
42
41
360
1.16
0.34
1.4
1.3
5.1
15.7
u/ml
—
8
126
7
53
1.33
0.31
5.3
2.5
0.8
0.9
nmol/l
—
7
38
52
574
0.89
0.30
4.2
5.1
—
—
—
0
0
137
1305
1.08
0.28
5.6
4.6
0.0
0.0
estimate
0.00
25
251
32
281
1.15
0.27
1.6
1.4
—
—
—
0
0
137
1311
1.07
0.24
4.2
3.4
0.0
0.0
estimate
0.00
25
246
123
1173
1.08
0.24
4.8
3.9
32.6
50.7
ng/l
0.82
103
871
0
11
0.00
0.21
0.0
1.3
—
—
—
0
0
0
11
0.00
0.21
0.0
1.2
—
—
—
0
0
0
11
0.00
0.21
0.0
1.3
—
—
—
0
0
0
11
0.00
0.21
0.0
1.4
—
—
—
0
0
0
11
0.00
0.21
0.0
1.0
—
—
—
0
0
0
11
0.00
0.21
0.0
1.2
—
—
—
0
0
0
11
0.00
0.21
0.0
6.9
—
—
—
0
0
0
11
0.00
0.21
0.0
1.5
—
—
—
0
0
0
11
0.00
0.21
0.0
2.4
—
—
—
0
0
0
11
0.00
0.21
0.0
1.2
—
—
—
0
0
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
1.2
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
0
12
0.00
0.21
0.0
2.6
—
—
—
0
0
0
12
0.00
0.21
0.0
1.5
—
—
—
0
0
0
12
0.00
0.21
0.0
1.8
—
—
—
0
0
0
13
0.00
0.21
0.0
1.0
—
—
—
0
0
0
14
0.00
0.20
0.0
1.4
—
—
—
0
0
0
14
0.00
0.20
0.0
1.6
—
—
—
0
0
9
115
0.78
0.20
1.1
1.1
—
—
—
0
0
138
1330
1.06
0.19
4.2
3.4
0.0
0.0
estimate
0.50
24
233
12
100
1.21
0.18
3.5
3.8
0.2
0.2
g/l
—
5
46
36
332
1.09
0.16
1.4
1.3
—
—
—
0
0
9
79
1.14
0.15
1.1
1.3
—
—
—
0
0
99
953
1.05
0.14
4.2
4.0
8.5
8.5
mg/mmol
0.00
64
625
15
132
1.14
0.13
3.6
2.3
—
—
—
0
0
54
568
0.94
0.12
5.1
3.7
1.0
1.0
kg/l
—
8
87
17
189
0.89
0.12
2.4
2.4
—
—
—
0
0
11
126
0.87
0.11
1.1
1.2
241.1
129.7
iu/ml
—
5
43
17
153
1.12
0.11
2.5
2.7
—
—
—
0
0
21
192
1.10
0.11
25.3
7.6
26.3
24.1
mmol/l
2.16
21
179
13
146
0.89
0.10
4.5
3.3
—
—
—
0
0
7
83
0.84
0.07
3.7
2.1
15.5
13.2
mg/l
—
7
77
14
130
1.08
0.04
2.9
6.4
1.5
1.6
%
0.23
14
121
16
150
1.07
0.04
1.1
1.2
—
—
—
0
0
37
358
1.04
0.04
1.4
1.3
—
—
—
0
0
104
1053
0.98
0.03
2.2
2.2
—
—
—
0
0
239
2377
1.02
0.03
4.5
4.1
2.0
2.0
mu/l
0.35
226
2127
27
278
0.97
0.02
1.8
2.2
118.8
130.3
ug/g
0.15
21
237
72
727
0.99
0.01
4.9
3.5
0.0
0.0
estimate
0.50
22
231
10
94
1.07
0.01
21.6
12.8
—
—
—
0
0
22
219
1.00
0.00
1.5
1.4
—
—
—
0
0
13
130
1.00
0.00
3.0
6.5
0.8
0.9
%
0.41
13
122
0
9
0.00
0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
0.00
0.0
1.6
—
—
—
0
0
0
6
0.00
0.00
0.0
2.5
—
12527.0
—
0
6
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
4.6
—
11.6
—
0
8
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
5
51
0.98
0.00
1.6
2.7
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0

Mortality – FinRegistry

Association

Association between endpoint G6_ALCOPOLY and mortality.

Females

Parameter HR [95% CI] p-value
G6_ALCOPOLY 6.471 [5.09, 8.24] < 0.001
Birth year 0.995 [0.99, 1.0] 0.275

During the follow-up period (1.1.1998 — 31.12.2019), 255 out of 596 females with G6_ALCOPOLY died.

Males

Parameter HR [95% CI] p-value
G6_ALCOPOLY 5.295 [4.65, 6.04] < 0.001
Birth year 0.984 [0.97, 0.99] 0.001

During the follow-up period (1.1.1998 — 31.12.2019), 1346 out of 2491 males with G6_ALCOPOLY died.

Mortality risk

Mortality risk for people of age

years, who have G6_ALCOPOLY.

N-year risk Females Males
1 0.432% 0.871%
5 3.556% 5.907%
10 9.79% 13.436%
15 17.855% 24.306%
20 29.641% 37.061%

Relationships between endpoints

Index endpoint: G6_ALCOPOLY – Alcohol induced polyneuropathy

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
loading spinner Loading data