No definition available.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519972 |
1. Apply sex-specific ruleNone |
519972 |
2. Check conditionsNone |
519972 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
486 |
4. Check minimum number of eventsNone |
486 |
5. Include endpointsNone |
486 |
6. Filter based on genotype QC (FinnGen only) |
464 |
Control definitions (FinnGen only)
- Control exclude
- J10_INTERSTITIUM
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF6
- Parent code in ICD-10
- J80-J84
- Name in latin
- Syndroma dyspnoicum adultorum
Similar endpoints
↥List of similar endpoints to
Adult respiratory distress syndrome
based on the number of shared cases.
Similar with more cases:
- Other respiratory diseases principally affecting the interstitium
- Condition for Implicit Sepsis (Organ dysfunction codes)
- Condition for Implicit Sepsis (Organ dysfunction codes)
- Diseases of the respiratory system
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 4454 | 1675 | 2699 |
| Only index persons | 2675 | 1057 | 1618 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.07 | 0.05 | 0.08 |
| Only index persons | 0.05 | 0.04 | 0.06 |
| Median age at first event (years) | |||
| Whole population | 64.11 | 63.05 | 64.59 |
| Only index persons | 63.57 | 61.33 | 65.04 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 464 | 168 | 296 |
| Unadjusted period prevalence (%) | 0.11 | 0.06 | 0.14 |
| Median age at first event (years) | 63.40 | 55.91 | 67.65 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 486
- Matched controls
- 4860
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
J80
ICD-10 Finland
Adult respiratory distress syndrome
+∞
307.7
464
*
J18.9
ICD-10 Finland
Pneumonia, unspecified
6.3
90.9
301
994
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
6.4
87.7
212
525
UGC12
NOMESCO Finland
Flexible bronchoscopy
7.0
66.0
118
213
J15.9
ICD-10 Finland
Bacterial pneumonia, unspecified
5.9
60.8
134
295
GD1DD
NOMESCO Finland
High resolution CT examination of lungs
9.2
54.3
71
89
WX730
NOMESCO Finland
Conventional respirator
20.3
52.3
41
22
WX872
NOMESCO Finland
Intensive care
7.1
49.1
82
136
J84.1
ICD-10 Finland
Other interstitial pulmonary diseases with fibrosis
516.1
48.2
47
*
GBB00
NOMESCO Finland
Tracheostomy
15.2
37.7
34
24
GD1AD
NOMESCO Finland
Thorax CT examination
5.8
34.9
69
134
J96.0
ICD-10 Finland
Acute respiratory failure
13.5
34.4
33
26
J84.9
ICD-10 Finland
Interstitial pulmonary disease, unspecified
+∞
33.7
32
*
TK800
NOMESCO Finland
Hemodialysis
9.4
33.3
41
47
FB1BD
NOMESCO Finland
Extensive CT examination of arteria pulmonalis
4.8
31.7
80
192
TGC00
NOMESCO Finland
Bronchial lavation
8.4
28.9
39
50
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
4.8
26.4
65
152
WX892
NOMESCO Finland
Monitored bed care
4.2
24.7
73
197
A41.9
ICD-10 Finland
Sepsis, unspecified
5.6
24.1
48
93
ZXD05
NOMESCO Finland
Urgent procedure
2.7
23.8
202
1022
5185A
ICD-9 Finland
Other diseases of lung, Pulmonary insufficiency following trauma and surgery
+∞
23.1
22
*
GD1BD
NOMESCO Finland
Thorax extensive CT-examination
4.6
22.9
59
143
GD1ED
NOMESCO Finland
Extensive high resolution CT examination of lungs
7.0
22.4
35
53
J01MA12
ATC
levofloxacin; systemic
2.7
20.4
140
629
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
2.7
19.5
136
614
J84.8
ICD-10 Finland
Other specified interstitial pulmonary diseases
+∞
18.9
18
*
TPH20
NOMESCO Finland
Insertion of central venous catheter through subclavian or brachiocephalic vein
5.8
18.6
35
64
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
3.0
18.6
94
357
C03CA01
ATC
furosemide; systemic
2.3
18.4
219
1259
H02AB06
ATC
prednisolone; systemic
2.3
17.4
268
1705
TPH07
NOMESCO Finland
Cathetrisation of artery
3.0
17.4
87
328
A49.9
ICD-10 Finland
Bacterial infection, unspecified
2.9
17.1
92
361
R91
ICD-10 Finland
Abnormal findings on diagnostic imaging of lung
3.1
16.9
82
303
J69.0
ICD-10 Finland
Pneumonitis due to food and vomit
6.1
15.9
28
48
J81
ICD-10 Finland
Pulmonary oedema
+∞
15.7
15
*
NK6QA
NOMESCO Finland
Measurement of bone density from two or more locations with X-ray
4.3
15.6
42
105
J13
ICD-10 Finland
Pneumonia due to Streptococcus pneumoniae
16.8
15.4
24
15
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.2
15.4
261
1699
WX882
NOMESCO Finland
High dependency care
5.5
15.3
30
57
GD5BD
NOMESCO Finland
Thorax and upper abdomen combined extensive CT examination of
7.1
15.0
23
34
A98
ICPC
Health maint/preventive medicine
0.4
14.8
322
3960
JN4BD
NOMESCO Finland
Extensive body CT
2.8
14.6
79
310
J01MA14
ATC
moxifloxacin; systemic
3.0
14.2
70
260
WX725
NOMESCO Finland
Noninvasive ventilation
3.9
14.1
43
118
R50.9
ICD-10 Finland
Fever, unspecified
2.6
13.7
95
422
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
2.8
13.6
77
309
L04AA06
ATC
mycophenolic acid; systemic
10.1
13.4
26
27
GCA98
NOMESCO Finland
Other bronchoscopic procedure on bronchus
17.9
12.6
19
11
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
2.8
12.6
71
284
J96.1
ICD-10 Finland
Chronic respiratory failure
5.0
12.5
27
56
127
Kela drug reimbursment
Transplant complication
11.5
12.1
22
20
I50.9
ICD-10 Finland
Heart failure, unspecified
2.3
11.8
112
570
WX722
NOMESCO Finland
PEEP
3.3
11.6
46
150
GAA10
NOMESCO Finland
Intercostal insertion of pleural drainage tube
5.9
11.6
21
37
N17.9
ICD-10 Finland
Acute renal failure, unspecified
3.7
11.4
37
106
XG410
NOMESCO Finland
Flow-volume spirometry
4.1
11.3
32
83
A40.3
ICD-10 Finland
Sepsis due to Streptococcus pneumoniae
20.6
11.2
16
8
XG470
NOMESCO Finland
Measurement of diffusion capastity of the lungs
5.0
10.6
23
48
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
2.8
10.6
57
222
WX704
NOMESCO Finland
Intubation
3.0
10.5
48
171
4859X
ICD-9 Finland
Bronchopneumonia, organism unspecified[PNEUMONIA NUD]
4.6
10.1
24
54
A10AC01
ATC
insulin (human); parenteral
2.7
10.1
57
227
B01AA03
ATC
warfarin; systemic
2.0
10.1
131
747
E10.9
ICD-10 Finland
Type 1 diabetes mellitus, Without complications
4.2
10.1
27
67
N05AA02
ATC
levomepromazine; systemic
3.6
9.9
33
96
JN3AA
NOMESCO Finland
Abdominal X-ray examination without contrast
3.6
9.8
33
97
WX726
NOMESCO Finland
High-flow oxygen therapy
+∞
9.4
9
*
Z2446
NOMESCO Finland
Social worker
2.9
9.3
44
159
N03AX16
ATC
[U] pregabalin
2.0
9.3
123
704
A41.5
ICD-10 Finland
Sepsis due to other Gram-negative organisms
3.7
9.2
29
81
ZXE30
NOMESCO Finland
More than five and less than seven hours
3.3
9.2
35
111
T36
ICD-10 Finland
Poisoning by systemic antibiotics
3.9
9.2
27
72
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
2.2
9.0
88
450
A01AB10
ATC
natamycin; local oral
4.5
9.0
22
51
DM1QA
NOMESCO Finland
Paranasal sinuses X-ray examination in one projection
3.7
8.9
29
83
GA4YT
NOMESCO Finland
Puncture of pleura with ultrasound guidance
3.7
8.9
29
83
Z3226
NOMESCO Finland
Physiotherapist
2.1
8.9
101
546
XG412
NOMESCO Finland
Flow-volume spirometry with bronchospasmolysis
3.2
8.9
36
119
R06.0
ICD-10 Finland
Dyspnoea
1.9
8.9
147
907
L04AX01
ATC
azathioprine; systemic
4.1
8.7
24
61
WX408
NOMESCO Finland
General anesthesy, balanced
1.9
8.7
132
791
TPH04
NOMESCO Finland
Cathetrisation of vein
2.0
8.6
121
705
I80.29
ICD-10 Finland
Phlebitis and thrombophlebitis of other deep vessels of lower extremities
3.8
8.6
26
71
J10.0
ICD-10 Finland
Influenza with pneumonia, seasonal influenza virus identified
8.1
8.4
18
23
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
1.8
8.3
151
956
E10.7
ICD-10 Finland
Type 1 diabetes mellitus, With multiple complications
4.5
8.2
20
46
E10.1
ICD-10 Finland
Type 1 diabetes mellitus, With ketoacidosis
17.5
8.1
12
7
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
2.4
7.8
58
263
A04.7
ICD-10 Finland
Enterocolitis due to Clostridium difficile
4.0
7.8
22
57
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
1.9
7.8
128
784
ZX120
NOMESCO Finland
Intravenous
2.3
7.6
59
274
GA1AE
NOMESCO Finland
Ultrasound examination of thorax
4.4
7.5
19
45
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
2.0
7.5
89
487
A10AB05
ATC
insulin aspart; parenteral
2.5
7.5
47
197
J44.8
ICD-10 Finland
Other specified chronic obstructive pulmonary disease
2.1
7.4
77
401
I80.3
ICD-10 Finland
Phlebitis and thrombophlebitis of lower extremities, unspecified
3.3
7.4
28
89
L04AD01
ATC
ciclosporin; systemic
7.0
7.4
17
25
RS220, ,
NOMESCO Finland
11.1
7.3
13
12
JN4AD
NOMESCO Finland
Body CT examination
2.3
7.3
58
271
WYA30
NOMESCO Finland
Treatment of a patient needing special arrangements
2.6
7.3
42
169
H02AB04
ATC
methylprednisolone; systemic
2.0
7.3
81
433
K85
ICD-10 Finland
Acute pancreatitis
4.6
7.2
17
38
R03AK03
ATC
[U] fenoterol and ipratropium bromide
2.5
7.2
47
201
K65.0
ICD-10 Finland
Acute peritonitis
8.1
7.2
15
19
N17.8
ICD-10 Finland
Other acute renal failure
8.1
7.2
15
19
C07AB07
ATC
bisoprolol; oral
1.7
7.1
255
1936
DM1AA
NOMESCO Finland
Paranasal sinuses X-ray examination without contrast
3.7
6.9
22
62
I25.1
ICD-10 Finland
Atherosclerotic heart disease
1.8
6.9
140
908
XG466
NOMESCO Finland
Sleep oxymetry
3.5
6.9
24
72
TPH90
NOMESCO Finland
Removal of fixed intravenous catheter
8.4
6.9
14
17
Z94.0
ICD-10 Finland
Kidney transplant status
11.1
6.8
12
11
R03BB04
ATC
tiotropium bromide; inhalant
2.1
6.8
69
357
Z49.1
ICD-10 Finland
Extracorporeal dialysis
6.6
6.7
16
25
X69
ICD-10 Finland
Intentional self-poisoning by and exposure to other and unspecified chemicals and noxious substances
4.3
6.6
17
41
J15.8
ICD-10 Finland
Other bacterial pneumonia
8.9
6.6
13
15
J93.8
ICD-10 Finland
Other pneumothorax
10.2
6.6
12
12
Z71.3
ICD-10 Finland
Dietary counselling and surveillance
3.2
6.5
25
80
J22
ICD-10 Finland
Unspecified acute lower respiratory infection
2.6
6.4
36
143
J12.8
ICD-10 Finland
Other viral pneumonia
8.3
6.4
13
16
TPX10
NOMESCO Finland
Implantation of vascular injection port
3.6
6.4
21
61
J01EE01
ATC
sulfamethoxazole and trimethoprim; systemic
2.6
6.3
36
144
J12.9
ICD-10 Finland
Viral pneumonia, unspecified
11.2
6.3
11
10
137
Kela drug reimbursment
Uraemia requiring dialysis
9.4
6.3
12
13
PJ2AT
NOMESCO Finland
Biopsy of lymphnode with ultrasound guidance
18.3
6.3
9
5
284
Kela drug reimbursment
Nintedanib and pirfenidone
+∞
6.3
6
*
GX2D5
NOMESCO Finland
Sleep oximetry
27.1
6.2
8
*
A02BC02
ATC
pantoprazole; systemic
1.6
6.2
316
2579
I46.0
ICD-10 Finland
Cardiac arrest with successful resuscitation
5.5
6.2
17
32
XF603
NOMESCO Finland
Direct intraarterial blood pressure measurement
3.0
6.1
27
94
A03FA02
ATC
cisapride; oral, rectal
2.4
6.1
44
197
TFB00
NOMESCO Finland
Cathetrisation of pulmonal artery
4.2
6.1
16
39
F10.1
ICD-10 Finland
Mental and behavioural disorders due to use of alcohol, Harmful use
2.4
6.1
41
178
GD1CD
NOMESCO Finland
Thorax extensive CT-examination
8.8
6.1
12
14
IAZ97
NOMESCO Finland
Psychiatric consultation in another specialty
6.8
6.1
14
21
ZXD00
NOMESCO Finland
Emergency procedure
3.4
6.1
21
63
TQW11
NOMESCO Finland
Vacuum treatment of wound
4.0
6.0
17
44
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
91
91
12.07
83.13
2.3
1.5
—
—
—
0
0
89
89
12.02
81.24
2.3
1.5
—
—
—
0
0
51
27
20.99
65.75
2.2
1.7
—
—
—
0
0
64
59
12.34
61.17
2.3
1.5
—
—
—
0
0
64
59
12.34
61.17
2.3
1.5
—
—
—
0
0
63
60
11.91
58.89
2.2
1.5
—
—
—
0
0
66
70
10.75
57.28
2.2
1.6
—
—
—
0
0
57
50
12.78
56.12
1.9
1.6
—
—
—
0
0
58
56
11.63
53.62
2.0
1.6
—
—
—
0
0
96
184
6.26
49.86
3.9
2.0
1.10
3.39
ug/l
0.81
91
163
54
53
11.34
49.28
2.1
1.5
—
—
—
0
0
44
37
12.98
44.26
2.2
1.5
—
—
—
0
0
44
37
12.98
44.26
2.2
1.5
—
—
—
0
0
49
50
10.79
43.44
2.2
1.6
—
—
—
0
0
43
44
10.62
37.95
2.2
1.5
—
—
—
0
0
40
41
10.54
35.21
2.1
1.7
—
—
—
0
0
141
483
3.70
34.65
14.4
5.9
1.08
1.02
mmol/l
1.14
133
445
38
38
10.76
34.01
2.2
1.7
—
—
—
0
0
69
138
5.66
33.78
3.8
3.2
—
—
—
0
0
156
606
3.32
31.07
7.4
3.5
0.84
0.82
mmol/l
0.96
148
568
121
411
3.59
29.70
22.7
9.5
93.15
95.45
%
2.27
115
400
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
62
130
5.32
28.69
5.8
2.4
0.33
0.36
u/ml
0.35
45
63
32
32
10.63
28.56
1.3
1.1
—
—
u/ml
—
0
0
125
448
3.41
28.08
23.0
9.3
2.32
1.19
mmol/l
2.02
109
363
44
68
7.02
27.75
14.7
7.7
284.62
168.00
iu/ml
0.64
13
11
123
448
3.34
26.81
23.4
9.2
5.10
5.15
kpa
0.19
117
429
123
449
3.33
26.70
23.4
9.2
9.84
11.70
kpa
5.82
118
432
159
684
2.97
25.93
3.3
1.8
—
—
—
0
0
124
473
3.18
24.86
2.9
1.8
—
—
—
0
0
36
52
7.40
24.07
1.3
1.3
—
—
—
0
0
121
471
3.09
23.30
2.7
1.7
—
—
—
0
0
29
34
9.01
22.99
2.2
1.6
—
—
—
0
0
29
34
9.01
22.99
2.2
1.6
—
—
—
0
0
29
34
9.01
22.99
2.2
1.6
—
—
—
0
0
28
32
9.22
22.62
2.1
1.5
—
—
—
0
0
81
277
3.31
19.15
2.2
1.6
—
—
—
0
0
63
190
3.66
18.06
1.8
2.2
1.79
1.50
g/l
1.10
50
161
74
259
3.19
16.76
7.5
3.2
2.76
2.00
mmol/l
1.01
61
194
38
85
4.76
16.17
2.5
1.4
—
—
—
0
0
23
15
16.02
14.54
1.7
1.1
—
—
—
0
0
62
212
3.21
14.53
29.7
12.3
—
—
—
0
0
81
324
2.80
14.39
3.0
2.6
62.13
66.09
g/l
3.00
75
289
103
474
2.49
13.77
6.4
4.0
303.59
241.39
u/l
2.79
95
446
336
4031
0.46
13.00
56.0
22.8
125.72
135.51
g/l
18.24
330
3952
336
4030
0.46
12.96
55.5
22.7
4.20
4.48
e12/l
13.69
328
3901
336
4027
0.46
12.82
57.8
22.9
38.13
40.02
%
6.04
299
3768
336
4026
0.46
12.77
56.0
22.7
244.50
242.43
e9/l
0.20
329
3909
29
63
4.83
12.76
2.2
1.4
219.58
102.67
u/ml
—
12
9
337
4029
0.47
12.56
55.3
22.7
8.27
6.80
e9/l
10.25
328
3900
82
359
2.54
12.10
6.6
3.7
1.91
2.01
mmol/l
0.08
70
294
81
358
2.52
11.70
6.7
3.7
5.92
5.79
kpa
0.42
76
347
75
322
2.57
11.50
1.7
2.0
326.27
381.49
nmol/l
1.60
70
290
20
18
11.53
11.14
2.6
1.8
—
—
—
0
0
32
85
3.96
10.93
11.6
4.4
5.01
5.12
kpa
0.34
32
85
37
109
3.59
10.92
2.7
1.5
—
—
—
0
0
20
19
10.92
10.86
2.6
1.7
—
—
—
0
0
32
86
3.91
10.76
4.7
2.2
14.27
15.53
%
0.87
22
45
61
246
2.69
10.58
6.5
3.3
116.79
127.10
g/l
2.06
56
241
31
85
3.83
10.14
3.6
1.9
119.50
128.34
g/l
0.92
26
65
20
22
9.43
10.10
2.4
1.6
—
—
—
0
0
20
22
9.43
10.10
2.4
1.6
—
—
—
0
0
56
222
2.72
10.03
18.9
7.8
25.10
24.71
mmol/l
0.40
56
222
20
23
9.02
9.87
2.6
1.7
—
—
—
0
0
327
3880
0.52
9.77
21.4
10.6
29.70
26.35
u/l
2.01
316
3721
303
3675
0.53
9.63
5.2
5.1
2.55
2.67
mmol/l
1.44
277
3347
27
71
3.97
9.35
1.6
1.2
—
—
—
0
0
18
19
9.79
9.34
2.5
1.6
—
—
—
0
0
18
19
9.79
9.34
2.5
1.6
—
—
—
0
0
101
540
2.10
9.20
4.8
2.4
19.33
21.90
%
1.02
80
470
18
20
9.30
9.10
2.5
1.6
—
—
—
0
0
14
10
14.37
8.74
1.6
1.3
—
—
—
0
0
236
1703
1.75
8.34
21.9
6.4
1.19
1.21
mmol/l
3.73
223
1534
25
68
3.82
8.28
1.6
1.2
192.35
295.57
u/ml
0.91
17
35
287
3488
0.57
8.22
31.9
14.4
77.41
78.15
ml/min/173m2
0.18
246
2913
17
21
8.35
8.15
1.6
1.9
—
—
—
0
0
299
3590
0.57
8.11
4.7
4.6
4.41
4.53
mmol/l
1.13
274
3293
24
65
3.83
8.00
3.6
2.6
6.39
4.91
e9/l
0.83
24
65
102
576
1.98
7.92
4.8
2.4
2.13
2.29
g/l
1.87
94
533
297
3565
0.57
7.90
4.7
4.5
1.37
1.42
mmol/l
1.43
273
3242
238
1741
1.72
7.86
12.6
5.8
21.38
26.62
%
8.69
229
1629
69
338
2.21
7.80
4.1
2.9
286.81
201.78
ng/l
0.48
64
306
233
1706
1.70
7.58
12.6
5.6
63.44
57.96
%
7.59
224
1597
302
3596
0.58
7.55
5.1
4.7
6.38
6.04
mmol/l
2.35
273
3245
107
624
1.92
7.53
4.7
2.4
10.37
12.53
umol/l
2.85
100
583
24
68
3.66
7.51
4.5
3.2
65.96
59.53
%
1.57
24
68
328
3819
0.57
7.50
49.7
18.2
138.87
139.69
mmol/l
5.38
323
3706
72
369
2.12
7.25
2.7
2.3
0.21
0.21
g/l
0.17
67
341
176
1205
1.72
7.25
4.6
3.2
44.30
32.37
u/l
1.86
167
1143
226
1661
1.67
7.11
10.8
4.8
31.08
35.25
g/l
14.22
210
1546
13
15
8.87
6.59
2.5
6.1
—
—
—
0
0
127
814
1.76
6.51
3.1
1.7
1.83
1.37
mg/l
0.78
110
638
243
1853
1.62
6.38
22.9
7.1
1.20
1.21
mmol/l
2.33
213
1572
288
3422
0.61
6.32
7.7
6.0
42.12
40.45
mmol/mol
1.73
264
3150
18
47
3.94
6.31
1.3
1.3
16064.40
28707.48
e6/l
—
10
25
58
1054
0.49
6.22
2.9
3.1
0.60
0.81
ug/l
1.33
38
708
56
276
2.16
6.22
7.6
3.9
136.71
86.29
ng/l
2.24
50
246
29
105
2.87
6.17
1.5
1.2
—
—
—
0
0
293
3460
0.61
6.15
4.7
4.1
1.46
1.28
mmol/l
3.51
271
3135
81
460
1.91
6.11
3.6
3.0
5.00
8.09
umol/l
3.30
69
411
257
2004
1.60
6.03
12.0
6.3
10.17
11.64
umol/l
2.86
249
1906
29
107
2.82
5.96
1.6
1.6
—
—
—
0
0
94
1457
0.56
5.96
3.7
4.5
24.30
21.19
%
0.96
37
718
35
144
2.54
5.84
1.4
2.3
41.17
38.04
u/l
0.22
29
127
25
87
2.98
5.71
2.1
1.4
—
—
—
0
0
24
83
2.99
5.54
1.8
1.4
—
—
—
0
0
24
83
2.99
5.54
1.8
1.4
—
—
—
0
0
17
47
3.71
5.53
1.0
1.2
—
—
—
0
0
16
35
4.69
5.22
1.6
1.4
—
—
—
0
0
22
75
3.02
5.21
1.5
1.4
—
—
—
0
0
243
1915
1.54
5.15
22.3
16.3
1.38
1.31
inr
0.45
64
541
15
41
3.74
4.96
2.7
4.0
—
—
—
0
0
261
2103
1.52
4.90
17.4
9.2
5.49
4.17
e9/l
8.30
237
1827
15
34
4.52
4.78
1.3
1.1
—
—
—
0
0
88
552
1.73
4.76
1.5
1.3
36.39
29.78
iu/ml
0.32
30
179
134
1823
0.63
4.74
4.0
5.2
1.60
2.84
ug/l
4.22
115
1614
22
81
2.80
4.57
1.8
1.4
—
—
—
0
0
167
1245
1.52
4.41
4.0
3.1
2781.90
1698.80
ng/l
0.96
151
1069
7
6
11.81
4.28
2.0
3.0
—
—
—
0
0
265
3099
0.68
4.15
45.6
18.7
15.12
15.21
%
0.12
260
3046
8
10
8.11
4.07
3.1
2.4
72.86
125.38
ug/l
—
8
10
327
3667
0.67
4.01
44.4
15.6
37.23
26.00
mg/l
5.27
303
2935
67
410
1.74
3.95
6.1
3.5
—
—
—
0
0
111
773
1.57
3.94
2.0
1.7
1135.75
1196.42
nmol/l
0.32
84
589
7
8
8.86
3.78
1.1
1.0
—
—
—
0
0
13
34
3.90
3.72
1.2
1.1
—
—
—
0
0
155
1176
1.47
3.64
3.2
2.1
332.76
213.51
u/l
0.40
148
1099
14
40
3.57
3.63
1.7
2.6
—
—
—
0
0
7
9
7.87
3.57
1.9
1.2
—
—
—
0
0
33
166
2.06
3.53
10.9
3.6
25.83
25.07
mmol/l
0.76
33
154
134
996
1.48
3.47
2.8
2.2
3.40
3.09
mg/l
0.79
115
859
146
1105
1.46
3.45
5.0
3.3
0.52
0.61
e6/l
0.27
116
840
10
22
4.62
3.44
1.7
1.4
—
—
—
0
0
14
48
2.97
3.32
2.1
1.4
—
—
—
0
0
15
54
2.83
3.28
2.1
1.8
30.67
33.35
pg
0.91
15
54
6
7
8.66
3.27
1.0
1.7
—
—
—
0
0
22
97
2.33
3.24
2.3
1.6
—
—
—
0
0
33
173
1.97
3.18
4.2
1.7
—
—
—
0
0
30
153
2.02
3.12
3.6
2.2
—
—
—
0
0
41
233
1.83
3.11
2.2
1.5
—
—
—
0
0
14
50
2.85
3.11
2.1
1.4
—
—
—
0
0
14
50
2.85
3.11
2.1
1.4
—
—
—
0
0
14
50
2.85
3.11
2.1
1.4
—
—
—
0
0
14
50
2.85
3.11
2.1
1.4
—
—
—
0
0
294
3306
0.72
3.05
4.9
4.4
2.09
1.96
mu/l
0.79
270
2955
14
51
2.80
3.01
2.1
1.4
—
—
—
0
0
77
526
1.55
2.95
1.4
1.3
16.81
6.82
u/ml
0.57
26
195
155
1216
1.40
2.94
5.1
3.3
60.40
115.68
e6/l
0.44
128
945
8
17
4.77
2.93
2.5
2.0
1700.50
827.18
u/ml
—
8
17
10
265
0.36
2.75
2.4
1.7
—
—
—
0
0
6
10
6.06
2.70
2.2
1.4
—
—
—
0
0
111
832
1.43
2.70
4.0
2.5
4.80
4.35
e6/l
0.22
104
748
105
783
1.43
2.62
6.5
4.0
848.88
254.86
ng/l
0.55
90
646
9
25
3.65
2.58
1.4
1.6
—
—
—
0
0
9
25
3.65
2.58
1.4
1.6
—
—
—
0
0
5
7
7.20
2.55
1.2
1.3
—
—
—
0
0
5
7
7.20
2.55
1.0
1.3
—
—
—
0
0
5
7
7.20
2.55
1.2
1.0
1710.40
1339.57
miu/ml
—
5
7
13
50
2.64
2.55
3.5
8.6
7.07
6.72
mmol/l
0.28
13
42
21
102
2.11
2.51
1.5
1.5
247.83
278.58
ug/g
0.26
12
57
173
1421
1.34
2.39
5.2
3.3
—
—
—
0
0
5
8
6.30
2.37
1.6
1.3
—
—
—
0
0
9
28
3.25
2.31
1.1
1.0
—
—
—
0
0
8
23
3.52
2.28
1.9
1.3
—
—
—
0
0
6
13
4.66
2.28
2.5
3.1
128.00
92.62
%
—
6
13
6
13
4.66
2.28
3.0
1.3
—
—
—
0
0
19
93
2.09
2.24
1.6
1.3
—
—
—
0
0
256
2237
1.31
2.23
18.0
5.1
7.53
6.78
mmol/l
5.01
249
2094
17
80
2.17
2.21
1.2
1.1
—
—
—
0
0
8
24
3.37
2.19
2.1
1.9
—
—
—
0
0
45
292
1.60
2.18
10.0
3.9
1.20
1.23
mmol/l
2.14
40
258
6
14
4.32
2.15
1.7
1.1
—
—
—
0
0
54
368
1.53
2.12
4.4
2.5
42.98
32.48
u/l
1.00
44
314
27
155
1.79
2.05
3.2
1.6
—
—
—
0
0
6
15
4.04
2.04
1.0
1.1
—
—
—
0
0
172
1438
1.30
2.04
3.2
2.2
73.22
77.14
nmol/l
1.04
155
1250
8
26
3.11
2.02
1.3
1.3
—
—
—
0
0
166
1388
1.30
1.95
6.0
3.8
169.46
101.77
e6/l
0.42
136
1005
5
11
4.58
1.94
2.4
2.5
37140.00
39464.09
ug/l
—
5
11
53
369
1.49
1.90
2.9
2.5
8.18
7.73
ug/l
0.04
45
323
7
22
3.21
1.88
2.0
1.3
—
—
—
0
0
7
22
3.21
1.88
2.0
1.3
—
—
—
0
0
8
28
2.89
1.87
1.3
3.5
—
—
—
0
0
12
53
2.30
1.82
1.1
1.1
2.80
9.53
u/ml
—
5
19
7
23
3.07
1.80
2.0
1.3
—
—
—
0
0
7
23
3.07
1.80
3.3
1.2
—
—
—
0
0
7
23
3.07
1.80
1.9
1.3
—
—
—
0
0
11
47
2.37
1.79
1.0
1.0
—
—
—
0
0
14
67
2.12
1.77
1.4
1.2
—
—
—
0
0
12
54
2.25
1.75
1.2
1.3
—
—
—
0
0
9
36
2.53
1.74
1.0
1.3
—
—
—
0
0
55
394
1.45
1.72
2.1
1.8
2.03
1.55
%
1.64
47
343
151
1273
1.27
1.63
6.1
3.4
2.30
2.34
mmol/l
2.02
133
1106
6
20
3.02
1.58
1.0
1.1
—
—
—
0
0
17
92
1.88
1.58
1.4
1.5
—
—
—
0
0
37
253
1.50
1.48
2.0
1.5
—
—
—
0
0
137
1157
1.26
1.44
3.9
3.0
6.72
7.78
mmol/l
2.26
119
942
17
96
1.80
1.40
1.1
1.1
—
—
—
0
0
12
60
2.03
1.39
1.2
1.1
—
—
—
0
0
9
41
2.22
1.37
2.6
2.5
—
—
—
0
0
9
41
2.22
1.37
1.3
1.3
0.47
0.50
nmol/l
—
9
34
176
1542
1.22
1.31
5.3
2.7
328.54
140.81
ug/l
2.58
166
1405
5
18
2.80
1.29
1.2
1.1
—
—
—
0
0
85
688
1.29
1.27
4.2
2.9
1.74
0.99
e6/l
0.62
51
409
42
306
1.41
1.24
3.7
2.8
60.70
66.90
ml/min/173m2
0.33
23
129
100
834
1.25
1.17
1.7
1.7
559.41
5764121.95
pmol/l
0.50
81
694
217
2386
0.84
1.16
5.6
3.2
100.87
52.75
u/l
2.00
201
2215
(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection
5
20
2.51
1.15
1.2
1.2
—
—
—
0
0
7
32
2.20
1.08
1.0
1.1
—
—
—
0
0
185
2047
0.84
1.03
3.1
2.8
—
—
—
0
0
7
37
1.90
0.94
1.7
1.9
—
—
—
0
0
15
95
1.60
0.88
1.1
1.1
—
—
—
0
0
161
1782
0.86
0.87
7.6
5.1
0.00
0.00
estimate
-0.00
38
329
11
64
1.74
0.87
1.5
1.1
172.87
34.10
u/l
0.45
11
53
134
1187
1.18
0.86
4.7
3.7
31.59
10.04
mg/mmol
1.33
94
760
8
46
1.75
0.83
1.3
1.7
—
—
—
0
0
6
32
1.89
0.82
1.7
1.2
—
—
—
0
0
21
147
1.45
0.81
1.1
1.3
—
—
—
0
0
6
33
1.83
0.79
1.5
1.5
29.82
30.34
u/l
—
6
28
116
1023
1.18
0.78
6.5
2.7
3422.27
7665.78
umol/l
0.63
97
882
108
952
1.17
0.74
1.9
1.6
17.94
20.72
nmol/l
1.44
100
788
15
100
1.52
0.73
1.5
1.3
—
—
—
0
0
77
660
1.20
0.72
4.8
3.1
1.81
1.74
e6/l
0.04
42
386
5
26
1.93
0.71
1.2
1.1
—
—
—
0
0
5
26
1.93
0.71
1.2
1.1
—
—
—
0
0
5
26
1.93
0.71
1.2
1.1
—
—
—
0
0
5
27
1.86
0.68
1.2
1.1
—
—
—
0
0
5
27
1.86
0.68
2.8
1.6
62.00
84.70
umol/l
—
5
27
5
27
1.86
0.68
1.2
1.1
—
—
—
0
0
5
27
1.86
0.68
1.2
1.1
—
—
—
0
0
250
2649
0.88
0.67
3.9
3.6
14.79
14.79
pmol/l
0.00
225
2353
166
1803
0.88
0.66
6.0
3.7
0.00
0.00
estimate
-0.00
35
312
125
1377
0.88
0.62
5.9
3.9
—
—
—
0
0
29
363
0.79
0.58
1.3
1.4
—
—
—
0
0
6
37
1.63
0.55
1.2
1.1
—
—
—
0
0
6
40
1.51
0.51
1.2
1.1
—
—
—
0
0
79
702
1.15
0.51
1.3
1.2
2.59
1.25
u/ml
0.41
23
197
166
1775
0.90
0.49
5.8
3.7
0.00
0.00
estimate
0.50
42
352
42
493
0.84
0.48
1.5
1.4
—
—
—
0
0
167
1560
1.11
0.48
6.6
3.9
51.07
51.77
ng/l
0.02
142
1140
7
51
1.38
0.44
1.3
2.7
—
32.00
—
0
9
5
32
1.57
0.42
1.6
1.4
—
—
—
0
0
5
33
1.52
0.41
1.0
1.1
—
—
—
0
0
0
15
0.00
0.41
0.0
1.1
—
—
—
0
0
0
19
0.00
0.39
0.0
1.3
—
—
—
0
0
28
235
1.20
0.37
2.0
2.5
—
14.32
—
0
14
101
934
1.10
0.36
5.2
2.5
—
—
—
0
0
24
199
1.22
0.35
1.2
1.2
17.33
138.10
iu/ml
—
7
79
6
44
1.37
0.34
1.2
1.1
—
—
—
0
0
297
2899
1.06
0.25
15.9
7.5
89.83
79.04
u/l
3.19
287
2695
5
41
1.22
0.22
1.4
1.3
—
—
—
0
0
0
11
0.00
0.21
0.0
1.0
—
—
—
0
0
0
11
0.00
0.21
0.0
2.2
—
2.37
—
0
6
92
970
0.94
0.20
2.0
1.7
1.54
1.34
mmol/l
1.11
81
812
6
52
1.16
0.19
2.0
1.6
—
—
—
0
0
81
774
1.06
0.14
5.9
4.1
1.01
1.02
kg/l
0.50
12
119
94
976
0.95
0.13
5.8
3.9
0.00
0.01
estimate
0.50
36
313
9
106
0.85
0.13
2.3
1.8
25.78
41.64
nmol/l
—
9
100
45
425
1.06
0.12
2.5
4.2
4.96
37.80
ug/l
1.06
40
351
21
229
0.91
0.11
4.4
2.7
0.24
0.31
e6/l
0.22
21
223
162
1591
1.03
0.08
2.5
2.0
93.14
93.36
pmol/l
0.02
104
844
6
74
0.81
0.07
1.0
3.7
3623.48
433.90
u/ml
—
6
68
7
84
0.83
0.07
1.9
1.7
—
—
—
0
0
178
1754
1.02
0.07
5.0
2.7
—
—
—
0
0
45
468
0.96
0.07
16.5
7.3
—
—
—
0
0
271
2736
0.98
0.07
7.1
3.8
21.93
12.88
mm/h
8.27
260
2485
8
92
0.87
0.07
1.4
1.7
—
—
—
0
0
22
230
0.95
0.03
1.8
1.7
—
—
—
0
0
10
107
0.93
0.02
1.6
1.8
—
—
—
0
0
10
94
1.07
0.01
1.5
1.3
—
—
—
0
0
25
256
0.98
0.00
1.9
1.8
—
—
—
0
0
12
125
0.96
0.00
1.3
1.7
4.42
3.11
mg/l
0.31
12
95
16
157
1.02
0.00
1.2
1.0
—
—
—
0
0
75
746
1.01
0.00
3.1
3.1
2.49
2.45
mmol/l
1.68
64
652
0
9
0.00
0.00
0.0
1.9
—
—
—
0
0
0
7
0.00
0.00
0.0
3.7
—
85.96
—
0
7
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
22.54
—
0
8
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.8
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.8
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
7
70
1.00
-0.00
1.4
1.5
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint J10_ARDS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| J10_ARDS | 4.114 [2.99, 5.67] | < 0.001 |
| Birth year | 0.993 [0.98, 1.0] | 0.123 |
During the follow-up period (1.1.1998 — 31.12.2019), 380 out of 840 females with J10_ARDS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| J10_ARDS | 3.869 [3.11, 4.82] | < 0.001 |
| Birth year | 0.988 [0.98, 1.0] | 0.02 |
During the follow-up period (1.1.1998 — 31.12.2019), 581 out of 1115 males with J10_ARDS died.
Mortality risk
Mortality risk for people of age
years, who have J10_ARDS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.343% | 0.847% |
| 5 | 2.574% | 4.935% |
| 10 | 6.118% | 11.15% |
| 15 | 11.445% | 19.998% |
| 20 | 18.726% | 31.948% |
Relationships between endpoints
↥Index endpoint: J10_ARDS – Adult respiratory distress syndrome
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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