No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
451 |
4. Check minimum number of eventsNone |
451 |
5. Include endpointsNone |
451 |
6. Filter based on genotype QC (FinnGen only) |
451 |
Control definitions (FinnGen only)
- Control exclude
- J10_INTERSTITIUM
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF6
- Parent code in ICD-10
- J80-J84
- Name in latin
- Syndroma dyspnoicum adultorum
Similar endpoints
↥List of similar endpoints to
Adult respiratory distress syndrome
based on the number of shared cases.
Similar with more cases:
- Other respiratory diseases principally affecting the interstitium
- Condition for Implicit Sepsis (Organ dysfunction codes)
- Diseases of the respiratory system
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 4454 | 1675 | 2699 |
| Only index persons | 2675 | 1057 | 1618 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.07 | 0.05 | 0.08 |
| Only index persons | 0.05 | 0.04 | 0.06 |
| Median age at first event (years) | |||
| Whole population | 64.11 | 63.05 | 64.59 |
| Only index persons | 63.57 | 61.33 | 65.04 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 451 | 160 | 291 |
| Unadjusted period prevalence (%) | 0.10 | 0.05 | 0.13 |
| Median age at first event (years) | 62.35 | 54.23 | 66.81 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 408
- Matched controls
- 4078
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
J80
ICD-10 Finland
Adult respiratory distress syndrome
+∞
323.0
386
*
J18.9
ICD-10 Finland
Pneumonia, unspecified
7.3
74.2
248
710
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
6.1
49.8
165
410
J15.9
ICD-10 Finland
Bacterial pneumonia, unspecified
7.3
41.8
111
199
J84.1
ICD-10 Finland
Other interstitial pulmonary diseases with fibrosis
+∞
33.8
32
*
UGC12
NOMESCO Finland
Flexible bronchoscopy
6.7
33.4
92
169
J84.9
ICD-10 Finland
Interstitial pulmonary disease, unspecified
+∞
28.5
27
*
WX872
NOMESCO Finland
Intensive care
7.7
27.3
66
99
5185A
ICD-9 Finland
Other diseases of lung, Pulmonary insufficiency following trauma and surgery
+∞
23.1
22
*
GD1DD
NOMESCO Finland
High resolution CT examination of lungs
7.9
21.4
50
71
WX730
NOMESCO Finland
Conventional respirator
13.2
18.9
33
27
FB1BD
NOMESCO Finland
Extensive CT examination of arteria pulmonalis
4.8
17.6
61
143
GD1BD
NOMESCO Finland
Thorax extensive CT-examination
5.9
17.5
50
94
GBB00
NOMESCO Finland
Tracheostomy
13.4
17.4
30
24
TPH07
NOMESCO Finland
Cathetrisation of artery
4.0
17.4
75
218
C03CA01
ATC
furosemide; systemic
2.5
16.8
180
968
TK800
NOMESCO Finland
Hemodialysis
9.2
16.8
35
41
A41.9
ICD-10 Finland
Sepsis, unspecified
6.8
15.8
40
64
J84.8
ICD-10 Finland
Other specified interstitial pulmonary diseases
+∞
15.7
15
*
H02AB06
ATC
prednisolone; systemic
2.3
14.9
218
1350
J96.0
ICD-10 Finland
Acute respiratory failure
14.9
14.7
24
17
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
2.8
14.5
107
458
GD1AD
NOMESCO Finland
Thorax CT examination
6.0
13.7
38
69
J81
ICD-10 Finland
Pulmonary oedema
+∞
13.6
13
*
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.2
13.3
201
1238
J01MA12
ATC
levofloxacin; systemic
2.6
13.0
112
521
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
4.2
12.9
50
131
WX892
NOMESCO Finland
Monitored bed care
3.9
12.8
54
153
GD1ED
NOMESCO Finland
Extensive high resolution CT examination of lungs
7.0
12.0
29
44
J13
ICD-10 Finland
Pneumonia due to Streptococcus pneumoniae
12.2
11.9
21
18
WX725
NOMESCO Finland
Noninvasive ventilation
5.4
11.8
35
69
TGC00
NOMESCO Finland
Bronchial lavation
7.3
11.5
27
39
R91
ICD-10 Finland
Abnormal findings on diagnostic imaging of lung
3.2
11.1
61
210
A98
ICPC
Health maint/preventive medicine
0.5
10.9
253
3168
JN4BD
NOMESCO Finland
Extensive body CT
2.9
10.5
68
265
WX722
NOMESCO Finland
PEEP
4.1
10.1
39
102
I50.9
ICD-10 Finland
Heart failure, unspecified
2.4
10.0
92
436
J01MA14
ATC
moxifloxacin; systemic
3.1
9.7
54
189
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
2.6
9.6
72
306
A49.9
ICD-10 Finland
Bacterial infection, unspecified
2.6
9.0
68
288
K65.0
ICD-10 Finland
Acute peritonitis
12.9
8.9
15
12
4859X
ICD-9 Finland
Bronchopneumonia, organism unspecified[PNEUMONIA NUD]
6.6
8.9
22
35
WX882
NOMESCO Finland
High dependency care
6.0
8.7
23
40
C07AB07
ATC
bisoprolol; oral
1.9
8.7
217
1540
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
2.9
8.6
53
199
GCA98
NOMESCO Finland
Other bronchoscopic procedure on bronchus
20.5
8.5
12
6
TPH20
NOMESCO Finland
Insertion of central venous catheter through subclavian or brachiocephalic vein
5.0
8.4
26
55
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
3.2
8.2
43
146
A01AB10
ATC
natamycin; local oral
6.1
8.1
21
36
GD5BD
NOMESCO Finland
Thorax and upper abdomen combined extensive CT examination of
6.3
7.9
20
33
GA4YT
NOMESCO Finland
Puncture of pleura with ultrasound guidance
4.6
7.9
26
59
NK6QA
NOMESCO Finland
Measurement of bone density from tow or more locations with X-ray
3.7
7.9
33
94
TPH90
NOMESCO Finland
Removal of fixed intravenous catheter
11.1
7.8
14
13
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
2.6
7.7
56
233
ZX120
NOMESCO Finland
Intravenous
2.8
7.6
51
201
L04AA06
ATC
mycophenolic acid; systemic
9.1
7.6
15
17
127
Kela drug reimbursment
Transplant complication
10.3
7.6
14
14
J96.1
ICD-10 Finland
Chronic respiratory failure
5.2
7.5
22
44
WX408
NOMESCO Finland
General anesthesy, balanced
2.0
7.4
112
652
XG410
NOMESCO Finland
Flow-volume spirometry
4.0
7.4
28
73
N17.9
ICD-10 Finland
Acute renal failure, unspecified
3.8
7.3
30
84
A40.3
ICD-10 Finland
Sepsis due to Streptococcus pneumoniae
9.6
7.3
14
15
B01AA03
ATC
warfarin; systemic
2.0
7.3
114
674
J20.9
ICD-10 Finland
Acute bronchitis, unspecified
2.2
7.2
79
405
J44.8
ICD-10 Finland
Other specified chronic obstructive pulmonary disease
2.3
7.1
68
327
N05CF01
ATC
zopiclone; oral
1.8
7.1
142
914
I80.29
ICD-10 Finland
Phlebitis and thrombophlebitis of other deep vessels of lower extremities
4.8
7.0
22
48
TPH04
NOMESCO Finland
Cathetrisation of vein
2.0
6.9
95
531
J69.0
ICD-10 Finland
Pneumonitis due to food and vomit
5.0
6.9
21
44
E10.1
ICD-10 Finland
Type 1 diabetes mellitus, With ketoacidosis
14.1
6.9
11
8
R50.9
ICD-10 Finland
Fever, unspecified
2.2
6.9
72
361
GD1CD
NOMESCO Finland
Thorax extensive CT-examination
11.2
6.8
12
11
E10.7
ICD-10 Finland
Type 1 diabetes mellitus, With multiple complications
5.8
6.8
18
32
R06.0
ICD-10 Finland
Dyspnoea
1.9
6.8
109
650
IAZ97
NOMESCO Finland
Psychiatric consultation in another specialty
17.0
6.8
10
6
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
1.9
6.7
124
777
N05AA02
ATC
levomepromazine; systemic
3.8
6.7
27
75
A10AC01
ATC
insulin (human); parenteral (insulins and analog. for injection, intermediate-acting)
2.7
6.6
45
179
DM1QA
NOMESCO Finland
Paranasal sinuses X-ray examination in one projection
4.4
6.5
22
52
N03AX16
ATC
pregabalin; oral
1.9
6.4
100
588
I25.1
ICD-10 Finland
Atherosclerotic heart disease
1.8
6.4
120
753
A02BC02
ATC
pantoprazole; systemic
1.7
6.4
249
1949
L04AX01
ATC
azathioprine; systemic
4.7
6.4
20
44
TFB00
NOMESCO Finland
Cathetrisation of pulmonal artery
6.4
6.2
15
24
E10.9
ICD-10 Finland
Type 1 diabetes mellitus, Without complications
4.0
6.2
23
60
J22
ICD-10 Finland
Unspecified acute lower respiratory infection
3.6
6.1
26
76
J10.0
ICD-10 Finland
Influenza with pneumonia, seasonal influenza virus identified
6.9
6.1
14
21
N17.8
ICD-10 Finland
Other acute renal failure
10.2
6.1
11
11
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
71
81
10.22
58.60
2.3
1.6
—
—
—
0
0
69
79
10.13
56.75
2.4
1.6
—
—
—
0
0
39
23
18.47
47.61
2.3
1.8
—
—
—
0
0
48
51
10.41
41.37
2.3
1.6
—
—
—
0
0
80
158
5.94
40.05
3.9
2.0
1.2
1.9
ug/l
0.52
75
140
51
62
9.15
39.73
2.2
1.6
—
—
—
0
0
43
44
10.70
38.00
2.0
1.7
—
—
—
0
0
44
48
10.05
37.13
2.0
1.6
—
—
—
0
0
43
46
10.23
36.80
2.1
1.6
—
—
—
0
0
35
38
9.90
29.52
2.2
1.6
—
—
—
0
0
35
41
9.17
27.87
2.2
1.7
—
—
—
0
0
141
554
3.25
27.43
7.5
3.5
0.8
0.8
mmol/l
1.30
134
518
121
438
3.41
26.86
14.8
6.0
1.1
1.0
mmol/l
1.10
115
406
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
57
123
5.16
25.53
5.8
2.4
0.3
0.4
u/ml
0.29
43
59
20
11
18.98
24.86
1.8
1.2
—
—
—
0
0
55
125
4.87
23.13
3.7
3.3
—
—
—
0
0
107
403
3.17
21.86
20.9
9.5
2.4
1.2
mmol/l
1.77
93
325
105
401
3.11
20.87
21.0
9.5
5.2
5.1
kpa
0.17
99
385
105
402
3.10
20.77
21.0
9.5
9.9
11.8
kpa
4.55
100
388
28
38
7.79
19.72
2.3
1.7
—
—
—
0
0
27
36
7.91
19.29
2.3
1.8
—
—
—
0
0
25
32
8.21
18.46
1.4
1.1
—
—
u/ml
—
0
0
23
27
8.92
18.16
2.0
1.6
—
—
—
0
0
30
49
6.49
17.88
1.3
1.1
—
—
—
0
0
34
65
5.58
17.30
16.4
8.0
357.6
168.0
iu/ml
—
9
11
103
431
2.80
17.09
2.8
1.8
—
—
—
0
0
132
626
2.57
17.07
3.2
1.8
—
—
—
0
0
100
430
2.70
15.64
2.6
1.8
—
—
—
0
0
16
14
11.81
15.39
2.5
1.9
—
—
—
0
0
84
335
2.85
15.13
25.0
10.5
113.6
120.4
g/l
1.92
79
326
301
3713
0.43
14.79
53.6
22.8
125.9
135.6
g/l
16.06
295
3644
301
3712
0.43
14.74
53.1
22.7
4.2
4.5
e12/l
12.54
294
3596
16
15
11.02
14.72
2.5
1.9
—
—
—
0
0
301
3708
0.43
14.54
53.7
22.7
245.6
242.3
e9/l
0.33
294
3603
70
258
3.03
14.51
2.2
1.6
—
—
—
0
0
55
177
3.40
14.26
1.9
2.3
1.7
1.5
g/l
0.53
44
152
20
31
6.70
12.47
2.1
1.7
—
—
—
0
0
20
31
6.70
12.47
2.1
1.7
—
—
—
0
0
20
31
6.70
12.47
2.1
1.7
—
—
—
0
0
16
19
8.69
12.44
2.5
1.8
—
—
—
0
0
33
82
4.26
12.33
2.5
1.4
—
—
—
0
0
63
241
2.88
12.15
7.4
3.3
2.8
2.0
mmol/l
1.15
52
181
268
3384
0.49
11.95
5.1
5.0
2.6
2.7
mmol/l
1.07
243
3086
54
194
3.03
11.64
29.7
12.7
—
—
—
0
0
15
18
8.59
11.55
1.5
2.0
—
—
—
0
0
292
3571
0.48
11.53
20.2
10.6
29.7
26.4
u/l
1.81
281
3431
73
324
2.50
10.47
6.6
3.8
2.1
1.9
mmol/l
0.09
61
260
15
21
7.35
10.19
2.3
1.6
—
—
—
0
0
15
21
7.35
10.19
2.3
1.6
—
—
—
0
0
15
21
7.35
10.19
2.3
1.6
—
—
—
0
0
15
21
7.35
10.19
2.3
1.6
—
—
—
0
0
88
434
2.28
9.94
5.9
4.0
310.8
237.0
u/l
2.97
81
409
72
325
2.45
9.94
6.7
3.8
6.0
5.8
kpa
0.74
67
315
266
3309
0.52
9.92
4.6
4.6
4.4
4.5
mmol/l
1.04
242
3039
254
3204
0.53
9.90
30.9
14.5
77.6
77.9
ml/min/173m2
0.06
217
2671
14
19
7.57
9.75
1.4
1.9
9.6
17.1
%
—
9
9
264
3285
0.53
9.70
4.6
4.5
1.4
1.4
mmol/l
1.16
241
2990
33
101
3.45
9.22
2.7
1.6
—
—
—
0
0
293
3516
0.52
9.17
46.5
18.3
138.9
139.7
mmol/l
4.56
288
3412
269
3309
0.54
9.09
5.1
4.7
6.4
6.0
mmol/l
2.40
241
2994
66
299
2.41
9.01
3.2
2.7
62.3
66.2
g/l
2.43
60
267
49
193
2.73
8.91
17.1
11.4
24.7
24.5
mmol/l
0.08
44
183
13
18
7.41
8.89
2.5
1.7
—
—
—
0
0
13
18
7.41
8.89
2.5
1.7
—
—
—
0
0
13
19
7.02
8.48
2.5
1.6
—
—
—
0
0
27
77
3.67
8.38
13.1
4.6
5.0
5.1
kpa
0.42
27
77
26
74
3.67
8.09
4.0
2.3
14.6
15.4
%
0.38
16
37
11
14
8.03
8.02
2.5
6.4
—
—
—
0
0
22
57
4.01
7.79
2.2
1.5
255.8
102.7
u/ml
—
9
9
261
3191
0.57
7.71
4.7
4.1
1.5
1.3
mmol/l
3.18
240
2894
64
307
2.26
7.64
4.1
2.9
284.1
200.2
ng/l
0.44
59
276
258
3161
0.57
7.63
7.6
6.0
42.1
40.5
mmol/mol
1.32
234
2916
30
98
3.21
7.58
5.8
2.0
7.2
7.9
kpa
1.11
30
85
79
1331
0.51
7.01
3.7
4.4
24.5
21.0
%
0.83
29
650
46
203
2.41
6.63
14.3
8.2
24.9
24.8
mmol/l
0.11
46
203
50
971
0.45
6.63
2.7
3.1
0.6
0.8
ug/l
1.41
32
648
66
342
2.09
6.48
2.5
2.3
0.2
0.2
g/l
0.31
61
318
87
499
1.92
6.43
5.0
2.5
19.0
22.2
%
1.23
70
437
20
57
3.63
6.23
3.4
2.6
6.8
4.9
e9/l
0.90
20
57
76
422
1.96
6.17
3.8
3.1
5.1
8.0
umol/l
2.76
66
377
10
8
12.75
6.11
1.2
1.4
—
—
—
0
0
159
1109
1.67
6.01
4.8
3.3
40.4
32.6
u/l
1.48
150
1051
208
1555
1.63
5.96
19.9
6.5
1.2
1.2
mmol/l
3.45
195
1392
23
75
3.18
5.85
3.0
2.0
121.6
127.4
g/l
0.37
18
57
89
530
1.85
5.83
4.9
2.4
2.1
2.3
g/l
1.53
83
490
20
60
3.44
5.79
3.6
3.2
65.9
58.7
%
1.52
20
60
116
1668
0.59
5.59
3.8
5.2
1.6
2.9
ug/l
3.99
100
1481
50
249
2.13
5.44
7.6
4.1
146.5
88.1
ng/l
2.41
44
222
292
3378
0.62
5.44
42.4
15.7
36.8
25.9
mg/l
4.35
269
2704
93
576
1.77
5.33
4.7
2.4
10.2
12.6
umol/l
3.04
87
534
21
71
3.05
5.05
1.9
1.4
—
—
—
0
0
21
71
3.05
5.05
1.9
1.4
—
—
—
0
0
200
1530
1.55
4.92
10.7
4.8
31.0
35.2
g/l
13.17
187
1425
8
8
10.15
4.53
11.5
11.4
—
—
—
0
0
19
65
3.01
4.49
1.6
1.2
—
—
—
0
0
228
1829
1.50
4.31
11.9
6.5
10.2
11.6
umol/l
2.27
220
1740
18
62
2.98
4.22
1.7
1.2
221.4
293.8
u/ml
0.47
12
33
256
2987
0.67
4.16
40.0
17.1
37.6
39.4
%
2.00
152
2072
109
750
1.60
4.14
3.2
1.7
1.8
1.4
mg/l
0.59
93
590
261
3033
0.67
4.14
4.7
4.3
2.1
2.0
mu/l
0.84
239
2707
12
32
3.83
4.11
1.1
1.1
—
—
—
0
0
8
10
8.12
4.07
3.1
2.4
72.9
125.4
ug/l
—
8
10
213
1701
1.48
4.03
21.2
7.2
1.2
1.2
mmol/l
1.83
186
1432
14
43
3.33
3.94
1.4
1.3
17116.0
29912.1
e6/l
—
9
22
24
101
2.45
3.88
1.7
1.6
—
—
—
0
0
23
95
2.50
3.87
1.5
1.2
—
—
—
0
0
103
710
1.58
3.87
2.1
1.8
1112.1
1171.7
nmol/l
0.30
77
542
18
68
2.72
3.60
1.5
1.4
—
—
—
0
0
9
253
0.34
3.42
2.4
1.7
—
—
—
0
0
12
37
3.30
3.36
2.8
4.2
—
—
—
0
0
20
83
2.48
3.35
2.0
1.4
—
—
—
0
0
234
2724
0.71
3.27
45.0
19.4
14.6
13.8
%
8.67
229
2671
6
7
8.67
3.27
1.3
1.3
—
—
—
0
0
11
33
3.39
3.21
1.7
1.4
—
—
—
0
0
9
21
4.35
3.01
1.8
1.3
—
—
—
0
0
138
1063
1.43
2.96
2.9
2.1
341.4
217.2
u/l
0.37
132
995
229
1928
1.38
2.91
16.8
9.2
5.4
4.2
e9/l
6.91
208
1674
27
137
2.03
2.86
1.4
2.2
44.7
37.8
u/l
0.44
21
120
10
31
3.28
2.79
1.4
1.1
—
—
—
0
0
17
74
2.35
2.61
1.8
1.4
—
—
—
0
0
11
38
2.94
2.60
1.8
2.8
—
—
—
0
0
119
914
1.41
2.56
2.8
2.2
3.4
3.1
mg/l
0.84
101
786
6
12
5.05
2.41
2.5
3.1
128.0
95.6
%
—
6
12
97
727
1.43
2.38
6.4
3.9
870.6
266.0
ng/l
0.50
82
591
5
8
6.30
2.37
1.2
1.0
—
—
—
0
0
56
375
1.56
2.37
6.2
3.4
—
—
—
0
0
156
1878
0.74
2.36
3.0
2.7
—
—
—
0
0
71
503
1.49
2.33
1.5
1.3
30.7
30.4
iu/ml
0.01
24
155
12
47
2.60
2.29
2.3
1.9
31.3
33.4
pg
0.63
12
47
6
13
4.66
2.28
1.7
1.1
—
—
—
0
0
133
1626
0.74
2.19
7.6
5.0
0.0
0.0
estimate
0.00
32
303
126
1001
1.36
2.18
4.8
3.3
0.5
0.6
e6/l
0.37
101
751
50
334
1.56
2.15
4.6
2.5
43.5
33.0
u/l
0.94
42
282
28
160
1.80
2.15
11.1
3.9
25.8
25.1
mmol/l
0.62
28
148
5
10
5.04
2.07
2.4
1.4
—
—
—
0
0
11
44
2.54
2.02
1.0
1.2
—
—
—
0
0
8
26
3.11
2.02
1.1
1.0
—
—
—
0
0
8
26
3.11
2.02
1.3
3.7
—
—
—
0
0
9
32
2.85
2.01
1.1
1.2
74.3
69.4
u/l
—
9
22
23
128
1.84
1.93
4.3
2.2
10.0
10.2
g/l
0.11
18
110
34
213
1.64
1.92
2.1
1.5
—
—
—
0
0
6
17
3.56
1.84
1.0
1.1
—
—
—
0
0
139
1146
1.31
1.84
3.9
3.2
3070.8
1688.7
ng/l
1.04
124
985
138
1646
0.77
1.83
5.8
3.7
0.0
0.0
estimate
0.00
29
285
7
23
3.07
1.80
2.3
1.9
—
—
—
0
0
11
47
2.37
1.79
2.1
1.4
—
—
—
0
0
23
133
1.77
1.73
4.3
2.2
3.3
3.2
g/l
0.15
17
103
194
2205
0.79
1.70
5.5
3.2
107.1
53.2
u/l
1.98
178
2050
24
142
1.73
1.68
4.2
2.1
3.6
3.7
g/l
0.25
17
101
24
142
1.73
1.68
4.2
2.1
7.5
7.5
g/l
0.01
17
106
24
142
1.73
1.68
4.2
2.1
—
—
—
0
0
29
446
0.63
1.66
1.4
1.4
—
—
—
0
0
8
31
2.61
1.66
1.0
1.3
—
—
—
0
0
11
49
2.28
1.65
2.1
1.4
—
—
—
0
0
11
49
2.28
1.65
2.1
1.4
—
—
—
0
0
11
49
2.28
1.65
2.1
1.4
—
—
—
0
0
11
49
2.28
1.65
2.1
1.4
—
—
—
0
0
11
50
2.23
1.58
2.1
1.4
—
—
—
0
0
219
2442
0.80
1.58
3.8
3.6
14.7
14.8
pmol/l
0.12
196
2166
16
86
1.89
1.52
1.6
1.3
—
—
—
0
0
47
336
1.45
1.51
2.8
2.5
8.4
7.7
ug/l
0.06
40
293
6
21
2.88
1.51
1.7
1.2
—
—
—
0
0
26
163
1.63
1.50
4.3
1.7
—
—
—
0
0
16
87
1.87
1.47
1.1
1.1
—
—
—
0
0
138
1611
0.79
1.47
5.5
3.7
0.0
0.0
estimate
0.00
34
294
6
22
2.75
1.44
1.8
1.4
—
—
—
0
0
105
1263
0.78
1.43
5.7
3.8
—
—
—
0
0
16
89
1.83
1.39
2.5
1.6
—
—
—
0
0
39
274
1.46
1.38
3.9
2.9
61.5
67.0
ml/min/173m2
0.27
22
114
38
266
1.47
1.37
11.0
4.0
1.2
1.2
mmol/l
2.51
33
234
9
41
2.22
1.37
1.0
1.0
—
—
—
0
0
6
23
2.63
1.37
1.7
1.7
—
—
—
0
0
6
23
2.63
1.37
1.7
1.7
—
—
—
0
0
5
17
2.96
1.36
2.2
2.0
1058.4
827.2
u/ml
—
5
17
154
1329
1.24
1.36
3.2
2.2
74.6
77.2
nmol/l
0.53
137
1154
6
24
2.52
1.31
1.3
1.4
—
—
—
0
0
62
479
1.34
1.29
1.4
1.3
20.5
6.1
u/ml
0.71
21
180
8
35
2.31
1.27
2.4
2.5
—
—
—
0
0
8
36
2.24
1.25
1.3
1.6
—
—
—
0
0
6
26
2.32
1.19
1.0
1.1
—
—
—
0
0
10
50
2.02
1.17
1.2
1.3
—
—
—
0
0
13
72
1.83
1.16
1.2
1.1
—
—
—
0
0
8
40
2.02
1.12
1.3
1.3
0.5
0.5
nmol/l
—
8
34
92
767
1.25
1.10
1.7
1.7
552.5
6289744.8
pmol/l
0.50
73
636
5
21
2.40
1.09
2.0
1.3
—
—
—
0
0
225
2057
1.19
1.04
16.5
5.1
7.4
6.8
mmol/l
3.58
217
1923
0
30
0.00
0.97
0.0
1.2
—
3.3
—
0
12
146
1295
1.19
0.94
5.2
3.3
—
—
—
0
0
6
28
2.16
0.92
1.5
1.5
29.8
31.0
u/l
—
6
23
46
361
1.31
0.90
2.2
1.8
2.1
1.6
%
1.39
39
317
14
87
1.63
0.88
1.1
1.1
—
—
—
0
0
6
31
1.95
0.84
1.7
1.2
—
—
—
0
0
10
57
1.77
0.84
1.6
1.1
189.4
36.1
u/l
—
10
48
132
1175
1.17
0.81
5.9
3.4
2.3
2.3
mmol/l
2.78
119
1019
21
149
1.43
0.77
3.5
1.6
—
—
—
0
0
6
34
1.77
0.76
1.2
1.1
—
—
—
0
0
13
84
1.56
0.72
1.5
1.5
—
—
—
0
0
73
623
1.20
0.72
4.1
3.0
1.6
1.0
e6/l
0.44
47
370
79
900
0.85
0.62
2.0
1.7
1.5
1.4
mmol/l
0.71
69
753
237
2505
0.89
0.62
6.5
3.8
22.0
13.1
mm/h
7.35
227
2275
8
53
1.52
0.58
1.3
1.1
—
—
—
0
0
18
135
1.35
0.52
1.2
1.3
—
—
—
0
0
79
883
0.87
0.49
5.4
3.8
0.0
0.0
estimate
0.50
30
285
152
1412
1.12
0.49
5.4
2.7
324.6
143.1
ug/l
2.01
142
1283
68
602
1.15
0.47
4.8
3.2
1.8
1.7
e6/l
0.08
42
354
71
635
1.14
0.43
1.2
1.2
1.0
1.0
u/ml
0.02
20
174
5
31
1.62
0.43
1.2
1.1
—
—
—
0
0
5
32
1.57
0.42
1.0
1.1
—
—
—
0
0
8
60
1.34
0.40
1.4
1.2
—
—
—
0
0
36
420
0.84
0.40
15.2
7.1
—
—
—
0
0
0
18
0.00
0.40
0.0
1.1
—
—
—
0
0
28
333
0.83
0.39
1.3
1.4
—
—
—
0
0
12
90
1.34
0.36
1.4
1.3
—
—
—
0
0
16
200
0.79
0.35
1.7
1.7
—
—
—
0
0
6
46
1.31
0.33
1.3
2.9
—
32.0
—
0
9
100
940
1.08
0.26
6.5
2.7
3985.5
7505.5
umol/l
0.41
82
804
21
180
1.17
0.24
1.2
1.2
18.6
144.6
iu/ml
—
6
73
27
237
1.15
0.23
1.7
1.6
—
—
—
0
0
5
41
1.22
0.22
1.0
1.1
—
—
—
0
0
19
220
0.86
0.22
1.7
1.8
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
56
520
1.09
0.20
29.6
26.6
2.0
1.3
inr
—
6
69
6
48
1.25
0.20
2.0
1.6
—
—
—
0
0
6
48
1.25
0.20
1.5
1.6
13.9
15.7
ug/l
—
6
48
0
14
0.00
0.20
0.0
1.1
—
—
—
0
0
113
1082
1.06
0.18
4.6
3.9
35.3
9.9
mg/mmol
1.29
78
698
92
876
1.06
0.18
1.9
1.6
18.2
20.5
nmol/l
0.94
85
725
90
857
1.06
0.17
5.2
2.6
—
—
—
0
0
20
183
1.10
0.10
1.1
1.4
—
47.5
—
0
15
142
1451
0.97
0.09
2.5
2.0
93.9
93.5
pmol/l
0.04
92
769
66
681
0.96
0.07
3.3
3.1
2.5
2.4
mmol/l
1.35
56
594
7
82
0.85
0.07
1.4
1.8
—
—
—
0
0
7
85
0.82
0.07
1.1
1.8
—
—
—
0
0
9
100
0.90
0.06
2.3
1.7
25.8
41.5
nmol/l
—
9
94
22
209
1.06
0.04
2.0
2.5
—
17.4
—
0
10
15
140
1.07
0.04
1.2
1.0
—
—
—
0
0
144
1426
1.01
0.03
6.0
3.9
53.6
47.5
ng/l
0.20
121
1041
265
2660
0.99
0.01
15.3
7.5
91.1
79.2
u/l
3.26
256
2473
40
392
1.02
0.01
2.7
4.3
5.4
40.6
ug/l
1.04
35
324
161
1602
1.01
0.01
7.5
4.2
—
—
—
0
0
69
696
0.99
0.00
5.4
4.0
1.0
1.0
kg/l
0.41
12
104
12
116
1.04
0.00
1.3
1.7
4.4
3.1
mg/l
0.32
12
85
21
213
0.99
0.00
4.4
2.7
0.2
0.3
e6/l
0.11
21
208
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
6
64
0.94
0.00
1.0
3.9
3623.5
452.0
u/ml
—
6
59
9
90
1.00
0.00
1.4
1.3
—
—
—
0
0
0
7
0.00
0.00
0.0
3.7
—
86.0
—
0
7
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.8
—
—
—
0
0
0
5
0.00
0.00
0.0
1.8
—
—
—
0
0
0
5
0.00
0.00
0.0
1.6
—
—
—
0
0
6
64
0.94
0.00
1.2
1.5
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
22.9
—
0
7
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
7
70
1.00
0.00
2.3
1.9
206.9
226.2
pmol/l
—
7
64
0
9
0.00
0.00
0.0
1.9
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint J10_ARDS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| J10_ARDS | 4.114 [2.99, 5.67] | < 0.001 |
| Birth year | 0.993 [0.98, 1.0] | 0.123 |
During the follow-up period (1.1.1998 — 31.12.2019), 380 out of 840 females with J10_ARDS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| J10_ARDS | 3.869 [3.11, 4.82] | < 0.001 |
| Birth year | 0.988 [0.98, 1.0] | 0.02 |
During the follow-up period (1.1.1998 — 31.12.2019), 581 out of 1115 males with J10_ARDS died.
Mortality risk
Mortality risk for people of age
years, who have J10_ARDS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.343% | 0.847% |
| 5 | 2.574% | 4.935% |
| 10 | 6.118% | 11.15% |
| 15 | 11.445% | 19.998% |
| 20 | 18.726% | 31.948% |
Relationships between endpoints
↥Index endpoint: J10_ARDS – Adult respiratory distress syndrome
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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