phototoxic dermatitis: a form of allergic contact dermatitis in which the allergen must be activated by light to sensitize the allergic response, and to cause a rash or other systemic effects on subsequent exposure. The second and subsequent exposures produce photoallergic skin conditions which are often eczematous. In rare cases the victims die.
Other and unspecified skin changes due to chronic exposure to nonionizing radiation
DOID EFO Endpoint Browser PheWeb
L12_NONIONRADISKINNAS
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519972 |
1. Apply sex-specific ruleNone |
519972 |
2. Check conditionsNone |
519972 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
481 |
4. Check minimum number of eventsNone |
481 |
5. Include endpointsNone |
481 |
6. Filter based on genotype QC (FinnGen only) |
469 |
Control definitions (FinnGen only)
- Control exclude
- L12_RADIATIONRELATEDSKIN
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
Similar endpoints
↥List of similar endpoints to
Other and unspecified skin changes due to chronic exposure to nonionizing radiation
based on the number of shared cases.
Similar with more cases:
- Skin changes due to chronic exposure to nonionizing radiation
- Radiation-related disorders of the skin and subcutaneous tissue
- Diseases of the skin and subcutaneous tissue
- Any operation in hilmo
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 3420 | 1992 | 1406 |
| Only index persons | 3066 | 1831 | 1235 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.05 | 0.06 | 0.04 |
| Only index persons | 0.06 | 0.07 | 0.05 |
| Median age at first event (years) | |||
| Whole population | 71.86 | 71.91 | 71.77 |
| Only index persons | 71.03 | 71.15 | 70.86 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 469 | 241 | 228 |
| Unadjusted period prevalence (%) | 0.09 | 0.09 | 0.10 |
| Median age at first event (years) | 68.90 | 67.66 | 70.21 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 481
- Matched controls
- 4810
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
L57.8
ICD-10 Finland
Other skin changes due to chronic exposure to nonionizing radiation
+∞
307.7
296
*
L57.0
ICD-10 Finland
Actinic keratosis
68.3
307.7
305
119
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
23.6
259.4
231
181
ZXC50
NOMESCO Finland
Cryotherapy
85.0
234.7
126
20
L57.9
ICD-10 Finland
Skin changes due to chronic exposure to nonionizing radiation, unspecified
3568.4
223.0
198
*
QAA25
NOMESCO Finland
Destruction of lesion of head or neck
108.1
210.8
109
13
QXA25
NOMESCO Finland
Destruction of lesion of skin, site unspecified
55.7
181.2
105
24
QAE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin in head or neck
10.0
114.3
161
231
TQW99
NOMESCO Finland
Other minor procedure on skin
15.9
105.6
98
76
D04.3
ICD-10 Finland
Carcinoma in situ: Skin of other and unspecified parts of face
38.0
100.0
63
19
C44.31
ICD-10 Finland
Basocellular carcinoma of the skin on another or unspecified part of the face
9.8
97.1
132
179
ZXC15
NOMESCO Finland
Use of photodynamic technique
49.6
97.0
57
13
D06BB10
ATC
imiquimod; topical
15.0
91.4
87
70
C44.32
ICD-10 Finland
Spinocellular carcinoma of the skin on another or unspecified part of the face
30.4
87.5
59
22
QAA05
NOMESCO Finland
Incision for biopsy of skin of head or neck
22.8
82.3
62
31
D48.5
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Skin
9.5
82.0
110
145
QAA50
NOMESCO Finland
Cryotherapy of skin of head or neck
117.8
74.5
79
8
XQ845
NOMESCO Finland
Dermatoscopy
36.2
72.4
46
14
QBA25
NOMESCO Finland
Destruction of lesion of skin of trunk
30.5
70.1
47
17
XQ848
NOMESCO Finland
Dermatological photography
19.9
69.0
55
31
C44.51
ICD-10 Finland
Basocellular carcinoma of the skin on the torso
13.4
56.7
56
47
R23.8
ICD-10 Finland
Other and unspecified skin changes
4.6
51.6
167
501
8090/3-C44.3
ICD-O-3
Basal cell carcinoma, NOS, of skin of other and unspecified parts of face
8.5
47.0
65
87
QBE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin of trunk
6.1
37.4
71
133
L30.9
ICD-10 Finland
Dermatitis, unspecified
3.8
34.8
138
465
ZXC20
NOMESCO Finland
Use of chemical agents
11.0
32.8
36
35
E0000UV, ,
ATC
3.0
31.8
258
1324
C44.41
ICD-10 Finland
Basocellular carcinoma of the skin of the scalp and neck
12.2
31.2
32
28
ZZR00
NOMESCO Finland
Flap of skin
8.9
29.5
38
46
8090/3-C44.5
ICD-O-3
Basal cell carcinoma, NOS, of skin of trunk
9.5
27.1
33
37
L56.8
ICD-10 Finland
Other specified acute skin changes due to ultraviolet radiation
+∞
26.3
25
*
QXA50
NOMESCO Finland
Skin cryotherapy, unspecified location
76.8
26.1
29
*
TEA00
NOMESCO Finland
Biopsy of lip
23.5
26.1
37
17
QCE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin in upper limb
8.3
25.9
35
45
D04.5
ICD-10 Finland
Carcinoma in situ: Skin of trunk
61.5
25.3
29
5
D07AB02
ATC
hydrocortisone butyrate; topical
2.7
22.8
186
919
D07AC01
ATC
betamethasone; topical
2.6
22.2
218
1175
E000001, ,
ATC
3.0
22.1
125
510
SPAT1153
SPAT
Removal of sutures
2.5
21.7
209
1114
L82
ICD-10 Finland
Seborrhoeic keratosis
2.9
21.4
129
543
D23.3
ICD-10 Finland
Benign neoplasm: Skin of other and unspecified parts of face
6.9
20.7
33
51
D07AB08
ATC
desonide; topical
3.4
20.7
83
275
D04.6
ICD-10 Finland
Carcinoma in situ: Skin of upper limb, including shoulder
37.6
20.0
25
7
C44.61
ICD-10 Finland
Basocellular carcinoma of the skin of the upper extremity including the shoulder
30.4
19.8
26
9
8070/3-C44.9
ICD-O-3
Squamous cell carcinoma, NOS, of skin, NOS
15.5
19.7
32
22
C44.30
ICD-10 Finland
Malignant tumor of the skin on another or unspecified part of the face without histology
17.7
19.4
30
18
D07AA02
ATC
hydrocortisone; topical
3.2
19.3
90
327
EAA10
NOMESCO Finland
Excision of lesion of lip
15.9
18.7
30
20
8090/3-C44.9
ICD-O-3
Basal cell carcinoma, NOS, of skin, NOS
3.9
18.6
58
162
D07AC13
ATC
mometasone; topical
2.5
18.5
169
866
S18
ICPC
Laceration/cut
2.3
18.4
267
1674
C44.02
ICD-10 Finland
Spinocellular carcinoma of the lip skin
98.8
17.7
19
*
QDE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin in lower limb
6.2
17.7
31
53
WXQ41
NOMESCO Finland
Photodynamic therapy of head and neck
+∞
16.8
16
*
ZXC07
NOMESCO Finland
Carbon dioxide laser
+∞
16.8
16
*
QAA40
NOMESCO Finland
Laser therapy or photocoagulation of skin of head or neck
93.4
16.7
18
*
D04.8
ICD-10 Finland
Carcinoma in situ: Skin of other sites
175.8
16.6
17
*
D04.7
ICD-10 Finland
Carcinoma in situ: Skin of lower limb, including hip
31.3
16.2
21
7
C44.81
ICD-10 Finland
Overall basocellular carcinoma of the skin
62.2
15.9
18
*
C44.39
ICD-10 Finland
Malignant tumor of the skin on another or unspecified part of the face other or unspecified histology
34.7
15.9
20
6
D07BB04
ATC
hydrocortisone butyrate and antiseptics; topical
2.8
14.5
81
323
D06BX02
ATC
ingenol mebutate; topical
15.0
14.2
23
16
QCA25
NOMESCO Finland
Destruction of lesion of skin of upper limb
43.9
14.2
17
*
TQW80
NOMESCO Finland
Local dermatologic skincare
6.9
14.1
22
33
E000002, ,
ATC
3.1
14.0
65
234
C44.52
ICD-10 Finland
Spinocellular carcinoma of the skin on the torso
35.2
13.6
17
5
K13.03
ICD-10 Finland
Keilit UNS
35.2
13.6
17
5
R21
ICD-10 Finland
Rash and other nonspecific skin eruption
4.4
13.5
35
85
QXE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin in uspecified region
21.9
13.4
19
9
P01BA02
ATC
hydroxychloroquine; oral
3.1
13.4
60
211
ZZA00
NOMESCO Finland
Split skin graft
4.7
13.3
31
69
D02AX
ATC
Other emollients and protectives
5.4
13.1
26
50
ZXC10
NOMESCO Finland
Use of laser
5.8
13.0
24
43
Z01.5
ICD-10 Finland
Diagnostic skin and sensitization tests
3.2
12.7
52
173
8070/3-C44.3
ICD-O-3
Squamous cell carcinoma, NOS, of skin of other and unspecified parts of face
33.0
12.6
16
5
D07BA04
ATC
hydrocortisone and antiseptics; topical
3.1
12.6
57
202
B07.9
ICD-10 Finland
Verruca simplex
5.3
12.3
25
49
EAA30
NOMESCO Finland
Partial excision of lower lip
38.6
12.3
15
*
L56.4
ICD-10 Finland
Polymorphous light eruption
38.6
12.3
15
*
E000007, ,
ATC
4.1
12.0
34
88
D01AC20
ATC
imidazoles/triazoles in combination with corticosteroids; topical
2.2
12.0
137
751
S08
ICPC
Skin colour change
3.5
11.9
42
127
S29
ICPC
Skin symptom/complaint other
2.3
11.9
108
539
S21
ICPC
Skin texture symptom/complaint
2.5
11.9
86
388
EP1AE
NOMESCO Finland
Neck ultrasound examination
3.3
11.7
46
149
-54
ICPC
Repair/fix-suture/cast/prosth device
5.9
11.6
21
37
D04.4
ICD-10 Finland
Carcinoma in situ: Skin of scalp and neck
36.0
11.3
14
*
D05BB02
ATC
acitretin; oral
5.7
11.3
21
38
WX723
NOMESCO Finland
CPAP therapy
4.6
10.9
26
59
C44.62
ICD-10 Finland
Spinocellular carcinoma of the skin of the upper extremity including the shoulder
28.8
10.8
14
5
QBA50
NOMESCO Finland
Cryotherapy of skin of trunk
61.4
10.7
12
*
WX780
NOMESCO Finland
Remote monitoring CPAP
4.2
10.6
28
69
DHB00
NOMESCO Finland
Excision of lesion of external nose
14.6
10.6
17
12
A02BC05
ATC
esomeprazole; systemic
1.9
10.3
215
1445
D07AD01
ATC
clobetasol; topical
2.3
10.2
91
449
TQW40, ,
SPAT
3.0
10.1
46
163
SPAT1256
SPAT
Intramuscular and subcutaneous injection
1.9
10.1
219
1487
D04.2
ICD-10 Finland
Carcinoma in situ: Skin of ear and external auricular canal
41.0
10.0
12
*
C44.42
ICD-10 Finland
Spinocellular carcinoma of the skin of the scalp and neck
41.0
10.0
12
*
L43.9
ICD-10 Finland
Lichen planus, unspecified
5.1
9.9
21
43
E000003, ,
ATC
3.8
9.9
30
82
ZQZ00
NOMESCO Finland
Treatment of several skin areas
20.5
9.9
14
7
8090/3-C44.4
ICD-O-3
Basal cell carcinoma, NOS, of skin of scalp and neck
10.3
9.6
18
18
WX110
NOMESCO Finland
Infiltration anesthesia
1.9
9.5
305
2320
SPAT1141
SPAT
Excision of skin or mucous membrane lesion
3.4
9.5
35
109
L81.4
ICD-10 Finland
Other melanin hyperpigmentation
12.7
9.4
16
13
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
1.8
9.2
235
1663
S77
ICPC
Malignant neoplasm of skin
9.3
9.1
18
20
X59
ICD-10 Finland
Exposure to unspecified factor
2.1
9.1
95
499
I10
ICD-10 Finland
Essential (primary) hypertension
1.9
9.0
345
2751
WZC20
NOMESCO Finland
Multidisciplinary treatment meeting
3.0
9.0
40
140
8090/3-C44.6
ICD-O-3
Basal cell carcinoma, NOS, of skin of upper limb and shoulder
19.0
9.0
13
7
C44.3
ICD-10 Finland
Malignant neoplasm: Skin of other and unspecified parts of face
24.5
8.9
12
5
D06AX01
ATC
fusidic acid; topical
2.6
8.8
55
231
L30.8
ICD-10 Finland
Other specified dermatitis
4.5
8.7
21
48
J01DB01
ATC
cefalexin; oral
2.0
8.6
384
3192
C44.71
ICD-10 Finland
Basocellular carcinoma of the skin of the lower extremity including the hip
10.3
8.6
16
16
H02AB06
ATC
prednisolone; systemic
1.8
8.5
245
1783
CBB30
NOMESCO Finland
Excision of lesion of eyelid
4.1
8.4
23
58
127
Kela drug reimbursment
Transplant complication
13.1
8.4
14
11
QCA50
NOMESCO Finland
Cryotherapy of skin of upper limb
+∞
8.4
8
*
L04AA01
ATC
[U] ciclosporin
11.0
8.3
15
14
H53.1
ICD-10 Finland
Subjective visual disturbances
3.0
8.3
38
135
D04.9
ICD-10 Finland
Carcinoma in situ: Skin, unspecified
14.8
8.2
13
9
8070/3-C44.2
ICD-O-3
Squamous cell carcinoma, NOS, of external ear
34.0
8.1
10
*
L56.9
ICD-10 Finland
Acute skin change due to ultraviolet radiation, unspecified
34.0
8.1
10
*
QAE99
NOMESCO Finland
Other excision or repair surgery of skin and subcutaneous tissue in head and neck
4.3
8.1
21
51
D22.5
ICD-10 Finland
Melanocytic naevi of trunk
3.5
8.1
28
84
SPAT1263
SPAT
Sampling
1.7
8.0
208
1460
C44.22
ICD-10 Finland
Spinocellular carcinoma of the skin of the outer ear and the outer ear canal
22.5
8.0
11
5
WXQ27
NOMESCO Finland
UVB narrow spectrum light therapy
22.5
8.0
11
5
L30.3
ICD-10 Finland
Infective dermatitis
3.7
8.0
25
70
M79.6
ICD-10 Finland
Pain in limb
1.7
8.0
198
1374
SPAT1312
SPAT
General health counselling
1.8
7.9
151
969
QAA99
NOMESCO Finland
Other local destruction of skin of head or neck
13.3
7.9
13
10
C07AB07
ATC
bisoprolol; oral
1.7
7.9
289
2230
XQ802
NOMESCO Finland
Epicutan test
3.9
7.9
23
61
C44.21
ICD-10 Finland
Basocellular carcinoma of the skin of the outer ear and the outer ear canal
8.7
7.9
16
19
ZXE00
NOMESCO Finland
One hour or less
1.7
7.8
193
1337
C44.50
ICD-10 Finland
Malignant tumor of the skin on the torso without histology
45.7
7.7
9
*
8070/3-C00.1
ICD-O-3
Squamous cell carcinoma, NOS, of external lower lip
45.7
7.7
9
*
R22.0
ICD-10 Finland
Localized swelling, mass and lump, head
3.8
7.7
23
62
C08CA01
ATC
amlodipine; oral
1.7
7.7
228
1657
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.7
7.7
250
1863
NB1AA
NOMESCO Finland
Shoulder X-ray examination without contrast
2.5
7.6
49
208
Z01.8
ICD-10 Finland
Other specified special examinations
1.9
7.5
114
679
D22.9
ICD-10 Finland
Melanocytic naevi, unspecified
3.4
7.3
26
79
UDC00
NOMESCO Finland
Ear microscopy
2.5
7.3
48
206
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.7
7.3
164
1100
L04AX01
ATC
azathioprine; systemic
3.5
7.2
25
75
SPAT1301
SPAT
No procedures
1.7
7.2
170
1156
QDA25
NOMESCO Finland
Destruction of lesion of skin of lower limb
20.4
7.2
10
5
L04AD01
ATC
ciclosporin; systemic
8.1
7.2
15
19
SPAT1325
SPAT
Vaccination
1.7
7.1
192
1352
NK4XE
NOMESCO Finland
Joint ultrasound examination not elsewhere classified
2.8
7.0
35
131
H04.10
ICD-10 Finland
Dry eye syndrome
2.2
7.0
59
284
DAB00
NOMESCO Finland
Excision of lesion of auricle
7.7
6.9
15
20
SPAT1260
SPAT
Consultation of another employee
1.9
6.9
95
547
A02BC02
ATC
pantoprazole; systemic
1.7
6.8
328
2678
L04AX03
ATC
methotrexate; systemic
2.4
6.7
48
215
TNX10
NOMESCO Finland
Arthrocentesis, unspecified region, unspecified region
2.6
6.6
39
159
M54.5
ICD-10 Finland
Low back pain
1.7
6.6
158
1073
L20.0
ICD-10 Finland
Besnier prurigo
3.2
6.5
25
80
UKC02
NOMESCO Finland
Cystoscopy
1.8
6.5
103
620
C08CA02
ATC
felodipine; oral
2.1
6.5
67
348
8070/3-C44.6
ICD-O-3
Squamous cell carcinoma, NOS, of skin of upper limb and shoulder
70.8
6.4
7
*
K13.09
ICD-10 Finland
Disease of the lips UNS
70.8
6.4
7
*
J01MA02
ATC
ciprofloxacin; systemic
1.6
6.3
205
1502
J01CA04
ATC
amoxicillin; systemic
1.7
6.3
358
3018
SPAT1149
SPAT
Suture or treatment of traumatic wound
2.0
6.3
73
396
8090/3-C44.0
ICD-O-3
Basal cell carcinoma, NOS, of skin of lip, NOS
27.1
6.2
8
*
8070/3-C44.5
ICD-O-3
Squamous cell carcinoma, NOS, of skin of trunk
27.1
6.2
8
*
R06AE09
ATC
levocetirizine; oral
2.1
6.2
62
318
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
1.9
6.2
85
488
D22.7
ICD-10 Finland
Melanocytic naevi of lower limb, including hip
6.4
6.2
15
24
C09CA03
ATC
valsartan; oral
2.1
6.2
57
284
D07CA01
ATC
hydrocortisone and antibiotics; topical
2.0
6.2
66
348
S82
ICPC
Naevus/mole
2.1
6.1
63
327
Z01.2
ICD-10 Finland
Dental examination
1.6
6.1
175
1241
J02AC01
ATC
fluconazole; systemic
1.7
6.1
157
1083
XKD00
NOMESCO Finland
Uroflowmetry
1.8
6.1
97
584
DAB10
NOMESCO Finland
Partial excision of auricle
12.7
6.1
10
8
SPAT1033
SPAT
Irrigation or wax removal of outer auditory canal
1.8
6.1
113
713
A98
ICPC
Health maint/preventive medicine
2.1
6.1
431
3862
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
100
418
2.76
16.47
5.0
3.9
—
—
—
0
0
430
3650
2.68
10.59
21.8
17.0
23.56
26.34
mg/l
0.90
354
2986
350
2739
2.02
10.57
4.3
3.9
15.07
15.08
pmol/l
0.01
310
2416
354
2804
1.99
10.02
5.2
4.2
16.53
14.62
mm/h
1.23
326
2544
163
1008
1.93
9.97
5.0
4.4
0.00
0.00
estimate
-0.00
77
308
315
2403
1.90
9.95
5.2
4.7
6.92
6.81
mmol/l
0.28
289
2256
245
1730
1.85
9.87
7.3
5.3
57.90
58.39
%
0.25
227
1615
24
57
4.38
9.48
4.3
2.8
63.54
59.79
%
0.64
24
57
369
2994
2.00
9.35
9.3
7.4
79.37
80.25
u/l
0.16
352
2781
23
54
4.42
9.22
4.2
2.3
4.80
4.41
e9/l
0.30
23
54
245
1758
1.80
9.12
7.9
5.6
27.16
26.22
%
0.62
228
1636
286
2150
1.81
9.10
8.9
8.7
4.11
4.27
e9/l
0.64
256
1879
35
115
3.20
8.74
1.7
1.4
—
—
—
0
0
254
1867
1.76
8.50
5.8
4.4
34.97
34.66
g/l
0.40
232
1732
438
3840
2.57
8.46
25.2
20.3
139.44
139.63
mmol/l
0.81
428
3724
438
3847
2.55
8.29
25.9
20.4
3.99
4.00
mmol/l
0.20
426
3731
370
3054
1.92
8.25
25.4
20.1
15.46
15.48
%
0.02
364
3010
205
1428
1.76
8.18
5.0
4.4
—
—
—
0
0
398
3371
2.05
8.17
5.3
4.8
1.99
2.00
mu/l
0.06
360
3000
250
1846
1.74
8.09
4.6
4.1
0.00
0.00
estimate
0.50
82
362
250
1850
1.73
7.99
5.9
5.5
0.00
0.00
estimate
-0.00
74
323
277
2117
1.73
7.81
21.8
17.6
1.25
1.34
inr
1.03
100
572
251
1871
1.71
7.72
4.7
4.1
0.00
0.00
estimate
-0.00
78
316
68
340
2.16
7.30
5.3
4.0
1.23
1.22
mmol/l
0.09
56
301
399
3437
1.94
7.01
7.5
6.4
40.90
40.92
mmol/mol
0.01
362
3139
440
3946
2.35
6.65
32.4
24.9
243.04
241.05
e9/l
0.24
428
3829
440
3947
2.35
6.63
32.1
25.0
39.48
39.17
%
0.46
387
3622
440
3947
2.35
6.63
32.3
24.9
4.37
4.38
e12/l
0.11
426
3813
440
3948
2.34
6.61
32.5
25.1
132.08
132.18
g/l
0.05
433
3860
178
1250
1.67
6.55
2.4
2.3
56.69
60.41
u/l
0.40
162
1152
26
87
3.10
6.33
3.0
2.4
17.37
15.24
%
2.58
16
43
19
52
3.76
6.26
1.4
1.7
32.32
32.15
pg
0.07
19
52
412
3625
1.95
6.25
6.1
5.3
2.50
2.58
mmol/l
0.96
370
3255
267
2106
1.60
5.98
3.3
3.1
44.43
53.69
u/l
1.27
249
1914
29
107
2.82
5.97
2.0
1.6
—
—
—
0
0
267
2112
1.59
5.86
8.3
6.4
1.21
1.21
mmol/l
0.35
204
1803
210
1583
1.58
5.58
2.5
2.2
80.95
79.14
nmol/l
0.45
190
1358
16
42
3.91
5.58
2.3
1.7
—
—
—
0
0
88
530
1.81
5.51
1.2
1.3
30.51
15.28
u/ml
0.45
36
186
385
3357
1.74
5.50
4.9
4.2
1.23
1.25
mmol/l
0.19
339
2973
134
913
1.65
5.37
3.4
2.7
4.80
4.98
e6/l
0.09
121
828
247
1946
1.55
5.32
6.4
5.6
1.21
1.21
mmol/l
0.56
222
1750
399
3527
1.77
5.26
5.6
4.7
4.39
4.48
mmol/l
0.92
358
3179
60
324
1.97
5.23
2.3
1.8
344.41
384.82
nmol/l
0.85
54
290
396
3496
1.75
5.21
5.4
4.6
1.46
1.47
mmol/l
0.29
353
3128
425
3836
1.93
5.14
14.7
11.0
24.26
23.69
u/l
0.38
408
3658
136
941
1.62
5.10
1.8
1.7
446.60
439.27
pmol/l
0.11
107
761
20
67
3.07
4.88
2.1
1.7
—
—
—
0
0
402
3583
1.74
4.87
5.8
5.0
6.02
6.08
mmol/l
0.47
358
3198
105
691
1.66
4.76
1.3
1.2
2.31
1.21
u/ml
0.31
27
164
14
30
4.77
4.71
2.4
1.8
—
—
—
0
0
203
1563
1.52
4.68
3.7
2.7
130.83
146.31
ug/l
0.63
188
1414
260
2115
1.50
4.56
6.5
6.1
10.69
11.87
umol/l
1.73
246
1999
24
95
2.61
4.37
2.0
1.6
—
—
—
0
0
143
1034
1.55
4.35
3.8
2.8
2567.13
9827.06
umol/l
1.85
124
871
134
955
1.56
4.35
1.9
1.6
1.24
1.29
mmol/l
0.38
104
793
164
1225
1.51
4.28
4.0
3.0
6.81
6.89
mmol/l
0.09
141
1002
17
56
3.11
4.28
2.2
1.6
—
—
—
0
0
169
1283
1.49
4.04
4.7
3.7
17.17
8.74
mg/mmol
0.84
103
807
190
1478
1.47
4.01
3.9
3.3
2.34
2.35
mmol/l
0.42
166
1272
169
1288
1.48
3.94
2.2
2.1
132.39
295.00
u/l
1.90
153
1204
212
1690
1.45
3.92
5.0
4.2
53.51
58.00
ng/l
0.08
162
1317
10
19
5.35
3.84
2.2
1.7
—
—
—
0
0
194
1532
1.45
3.72
4.5
3.3
—
—
—
0
0
188
1476
1.45
3.72
5.0
3.9
107.81
104.43
e6/l
0.03
146
1093
10
20
5.08
3.70
2.2
1.7
—
—
—
0
0
159
1213
1.46
3.64
4.0
3.1
1142.81
210.59
mg/l
0.84
107
782
22
92
2.46
3.61
2.1
1.6
—
—
—
0
0
85
569
1.60
3.56
1.2
1.3
49.19
46.52
iu/ml
0.04
24
185
93
637
1.57
3.54
3.6
2.3
2.31
2.31
g/l
0.00
82
584
22
94
2.40
3.46
1.4
1.2
2.02
2.23
u/ml
—
5
17
88
604
1.56
3.31
3.8
2.4
21.23
21.07
%
0.04
67
520
217
1781
1.40
3.23
2.5
2.7
—
—
—
0
0
223
1843
1.39
3.17
2.0
2.1
97.01
93.65
pmol/l
0.42
119
953
377
3417
1.48
3.10
21.8
16.1
70.88
72.61
ml/min/173m2
0.86
337
2834
93
659
1.51
3.02
3.7
3.1
0.79
0.82
mmol/l
1.65
84
618
10
26
3.90
2.99
2.2
1.6
—
—
—
0
0
6
9
6.73
2.87
1.8
1.0
11.10
9.70
ug/l
—
6
9
129
985
1.42
2.85
1.9
1.8
1202.86
1180.98
nmol/l
0.09
99
738
7
14
5.06
2.73
4.3
5.2
—
—
—
0
0
14
54
2.64
2.72
1.8
1.8
87.04
89.03
%
0.35
14
54
81
570
1.51
2.72
10.4
4.5
1.05
1.03
mmol/l
0.26
76
516
116
876
1.43
2.72
5.9
4.0
505.34
275.52
ng/l
0.34
90
756
142
1114
1.39
2.67
2.1
2.2
3.34
3.22
mg/l
0.22
124
953
32
177
1.87
2.67
1.7
1.7
—
—
—
0
0
30
164
1.88
2.60
1.5
1.5
—
—
—
0
0
207
1734
1.34
2.54
2.7
2.4
—
—
—
0
0
162
1312
1.35
2.47
4.5
3.4
107.84
120.33
e6/l
0.07
136
1035
149
1198
1.35
2.37
4.1
3.3
0.56
0.52
e6/l
0.08
123
923
29
162
1.84
2.37
3.3
3.3
—
—
—
0
0
94
701
1.42
2.35
3.6
2.3
12.27
12.22
umol/l
0.02
84
644
50
327
1.59
2.33
1.8
1.7
—
—
—
0
0
170
1398
1.33
2.32
6.5
5.5
2.70
3.09
ug/l
0.27
145
1221
36
217
1.71
2.29
2.7
2.0
14.68
12.80
nmol/l
0.54
27
185
177
1471
1.32
2.23
3.6
3.1
2043.52
1796.90
ng/l
0.25
151
1280
5
9
5.60
2.22
1.2
1.1
—
—
—
0
0
13
54
2.45
2.21
2.0
1.6
—
—
—
0
0
14
61
2.33
2.16
2.0
1.6
—
—
—
0
0
17
81
2.14
2.15
1.4
1.6
—
—
—
0
0
50
335
1.55
2.12
5.7
3.3
110.78
87.82
ng/l
1.03
40
289
13
56
2.36
2.06
2.2
1.6
—
—
—
0
0
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
24
137
1.79
1.87
2.2
2.5
0.36
0.39
u/ml
0.11
16
77
41
271
1.56
1.86
5.5
3.9
2.30
2.06
mmol/l
0.16
29
205
104
820
1.34
1.85
1.6
1.7
1.09
1.34
mg/l
0.71
72
651
20
108
1.89
1.84
1.7
1.8
20471.80
20700.28
e6/l
—
10
78
111
885
1.33
1.83
3.1
3.1
2.45
2.46
mmol/l
0.49
100
772
15
75
2.03
1.71
1.2
1.3
—
—
—
0
0
10
40
2.53
1.67
1.8
1.5
—
—
—
0
0
134
1113
1.28
1.63
1.6
1.6
20.87
21.09
nmol/l
0.06
118
923
14
70
2.03
1.60
2.1
1.5
—
—
—
0
0
52
377
1.43
1.54
2.3
3.2
65.38
66.17
g/l
0.29
46
336
11
51
2.18
1.51
1.6
1.6
—
—
—
0
0
6
21
2.88
1.51
1.0
1.5
—
—
—
0
0
6
21
2.88
1.51
1.0
1.5
—
—
—
0
0
24
147
1.67
1.50
2.0
4.0
46.26
31.45
mg/l
0.40
18
121
24
147
1.67
1.50
2.0
4.0
75.64
108.40
mg/l
0.31
18
119
18
103
1.78
1.43
1.4
1.4
—
—
—
0
0
11
53
2.10
1.39
1.8
1.8
57.00
50.02
nmol/l
0.34
11
48
6
23
2.63
1.37
1.3
1.3
—
—
—
0
0
5
17
2.96
1.36
1.4
3.1
217.00
160.82
nmol/l
—
5
17
0
40
0.00
1.33
0.0
1.1
—
1.30
—
0
10
14
77
1.84
1.26
1.4
1.2
—
—
—
0
0
52
396
1.35
1.19
1.6
1.3
—
—
—
0
0
85
694
1.27
1.19
1.9
1.8
30.12
29.58
s
0.29
78
668
12
65
1.87
1.14
1.2
1.5
—
—
—
0
0
12
65
1.87
1.14
1.2
1.5
—
—
—
0
0
11
193
0.56
1.10
1.4
3.5
16.50
1508.44
u/ml
—
6
164
5
21
2.40
1.09
5.6
2.7
—
—
—
0
0
9
47
1.93
1.02
5.3
4.8
10.60
12.20
mg/l
—
9
42
89
745
1.24
1.02
2.6
1.9
—
—
—
0
0
99
839
1.23
1.01
4.2
4.7
1.02
1.02
kg/l
0.34
14
133
11
61
1.82
0.99
1.7
1.4
—
—
—
0
0
49
382
1.31
0.99
1.8
2.0
0.19
0.20
g/l
0.05
44
352
130
1143
1.19
0.91
3.2
3.0
30.67
33.48
u/l
0.43
118
1092
50
397
1.29
0.89
1.7
1.3
—
—
—
0
0
26
187
1.41
0.87
2.0
2.2
—
—
—
0
0
20
137
1.48
0.85
1.4
1.2
—
—
—
0
0
8
45
1.79
0.84
2.3
2.6
—
—
—
0
0
38
294
1.32
0.83
2.5
2.7
50.21
57.76
ml/min/173m2
0.74
24
128
8
47
1.71
0.81
1.0
1.2
—
—
—
0
0
17
114
1.51
0.80
1.2
1.4
—
—
—
0
0
22
156
1.43
0.80
2.2
2.5
1.37
0.81
g/l
0.40
17
135
0
24
0.00
0.79
0.0
3.8
—
—
—
0
0
0
24
0.00
0.79
0.0
2.1
—
—
—
0
0
39
491
0.78
0.78
3.4
4.2
3.02
35.64
ug/l
1.31
32
421
28
209
1.36
0.77
1.3
1.9
1.45
1.61
g/l
0.46
23
182
6
34
1.77
0.76
1.7
1.1
—
81.83
—
0
6
5
24
2.09
0.74
1.2
1.3
—
—
—
0
0
5
24
2.09
0.74
1.2
1.3
—
—
—
0
0
5
25
2.01
0.73
1.0
1.2
—
—
—
0
0
7
39
1.81
0.72
1.0
1.6
—
—
—
0
0
7
39
1.81
0.72
1.0
1.6
—
—
—
0
0
7
39
1.81
0.72
1.0
1.6
—
—
—
0
0
7
40
1.76
0.71
1.0
1.6
—
—
—
0
0
18
126
1.45
0.71
1.3
1.5
—
—
—
0
0
5
26
1.93
0.71
1.0
1.1
—
—
—
0
0
17
238
0.70
0.69
4.1
3.6
41.88
48.52
%
0.44
17
233
7
42
1.68
0.68
1.0
1.6
—
—
—
0
0
10
62
1.63
0.65
1.1
1.4
—
—
—
0
0
17
120
1.43
0.65
1.5
1.4
—
—
—
0
0
16
113
1.43
0.62
3.6
2.6
89.11
65.22
ug/min
—
9
68
13
88
1.49
0.61
1.5
1.4
—
—
—
0
0
10
64
1.57
0.59
1.2
1.3
—
—
—
0
0
8
53
1.52
0.58
1.0
1.0
—
—
—
0
0
8
54
1.49
0.57
1.4
1.4
—
—
—
0
0
20
150
1.35
0.56
1.1
1.0
—
—
—
0
0
6
38
1.59
0.54
2.8
2.7
—
—
—
0
0
6
39
1.55
0.53
1.2
1.1
—
—
—
0
0
65
737
0.86
0.49
3.6
2.8
1.40
1.13
e6/l
0.34
42
425
38
451
0.83
0.49
2.7
2.6
9.89
8.78
umol/l
0.09
27
394
7
46
1.53
0.48
2.0
1.3
32.44
31.18
iu/l
—
7
41
11
154
0.71
0.47
1.5
1.7
—
—
—
0
0
0
18
0.00
0.40
0.0
3.2
—
213.50
—
0
18
5
35
1.43
0.39
1.2
1.1
—
—
—
0
0
0
19
0.00
0.39
0.0
1.2
—
—
—
0
0
46
522
0.87
0.37
7.2
8.5
—
—
—
0
0
6
44
1.37
0.34
1.7
1.3
—
—
—
0
0
6
44
1.37
0.34
1.3
1.5
—
—
—
0
0
6
44
1.37
0.34
2.3
1.2
0.73
0.59
nmol/l
—
6
38
6
44
1.37
0.34
1.3
1.5
—
—
—
0
0
6
46
1.31
0.33
1.7
1.6
—
—
—
0
0
47
418
1.14
0.32
2.4
2.6
4.47
6.07
ug/l
0.41
42
356
7
54
1.30
0.30
5.9
4.4
—
—
—
0
0
57
519
1.11
0.28
5.5
4.9
34.53
32.47
%
0.72
45
325
8
63
1.27
0.28
1.3
1.1
—
—
—
0
0
58
531
1.10
0.26
5.1
6.5
1.26
1.47
mmol/l
0.19
42
425
21
181
1.17
0.23
1.5
1.1
62.13
129.45
iu/ml
—
8
67
13
156
0.83
0.21
2.4
2.0
230.28
603.84
ug/l
0.65
13
147
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
0
11
0.00
0.21
0.0
1.4
—
—
—
0
0
0
11
0.00
0.21
0.0
1.3
—
—
—
0
0
0
11
0.00
0.21
0.0
1.2
—
—
—
0
0
0
10
0.00
0.21
0.0
1.4
—
—
—
0
0
0
10
0.00
0.21
0.0
1.2
—
—
—
0
0
0
10
0.00
0.21
0.0
1.2
—
—
—
0
0
0
12
0.00
0.21
0.0
1.0
—
378.67
—
0
6
6
48
1.25
0.20
1.3
1.4
—
—
—
0
0
6
49
1.23
0.20
1.3
1.4
—
—
—
0
0
6
49
1.23
0.20
1.3
1.4
—
—
—
0
0
6
49
1.23
0.20
1.3
1.4
—
—
—
0
0
6
49
1.23
0.20
1.3
1.4
—
—
—
0
0
6
50
1.20
0.20
1.3
1.4
—
—
—
0
0
6
53
1.13
0.18
1.7
1.7
—
—
—
0
0
117
1123
1.06
0.17
5.3
4.7
22.94
21.86
%
0.37
62
579
57
534
1.08
0.17
5.1
6.5
4.95
5.08
kpa
0.48
52
513
57
535
1.07
0.16
5.1
6.5
12.39
11.65
kpa
0.50
52
515
10
84
1.19
0.14
1.5
1.3
—
—
—
0
0
76
793
0.95
0.13
3.9
3.2
0.96
0.83
ug/l
0.21
62
555
10
116
0.86
0.12
1.1
1.7
—
—
—
0
0
56
534
1.06
0.11
2.5
1.8
—
—
—
0
0
46
436
1.06
0.11
5.4
3.0
1.29
2.15
mmol/l
0.94
38
349
12
135
0.89
0.10
1.2
1.2
—
—
—
0
0
12
133
0.90
0.07
1.2
1.2
—
—
—
0
0
25
237
1.06
0.06
2.2
2.7
—
12.58
—
0
17
10
91
1.10
0.04
1.0
1.6
—
—
—
0
0
27
260
1.04
0.03
1.6
1.4
—
—
—
0
0
16
167
0.96
0.01
1.4
1.3
—
—
—
0
0
29
297
0.97
0.01
1.4
1.6
—
—
—
0
0
96
954
1.01
0.00
2.3
2.5
—
—
—
0
0
53
535
0.99
0.00
2.5
1.9
—
—
—
0
0
70
697
1.01
0.00
4.3
3.0
3.41
2.50
e6/l
0.34
47
389
0
5
0.00
-0.00
0.0
1.0
—
44.80
—
0
5
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
(3011547) Coagulation factor VII activity actual/normal in Platelet poor plasma by Coagulation assay
0
5
0.00
-0.00
0.0
1.0
—
129.80
—
0
5
0
5
0.00
-0.00
0.0
1.0
—
112.80
—
0
5
0
8
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
3.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
7
73
0.96
-0.00
1.1
1.1
—
—
—
0
0
5
50
1.00
-0.00
1.2
1.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.4
—
0.60
—
0
5
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.7
—
78.43
—
0
7
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
9
96
0.94
-0.00
1.2
1.2
—
—
—
0
0
7
71
0.99
-0.00
1.4
1.2
7.70
42.51
u/l
—
7
59
0
5
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
99.40
—
0
5
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
9
96
0.94
-0.00
1.2
1.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
3.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.7
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint L12_NONIONRADISKINNAS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_NONIONRADISKINNAS | 0.839 [0.75, 0.94] | 0.003 |
| Birth year | 0.995 [0.99, 1.0] | 0.298 |
During the follow-up period (1.1.1998 — 31.12.2019), 659 out of 1855 females with L12_NONIONRADISKINNAS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_NONIONRADISKINNAS | 0.902 [0.79, 1.03] | 0.133 |
| Birth year | 0.986 [0.98, 1.0] | 0.004 |
During the follow-up period (1.1.1998 — 31.12.2019), 578 out of 1306 males with L12_NONIONRADISKINNAS died.
Mortality risk
Mortality risk for people of age
years, who have L12_NONIONRADISKINNAS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.097% | 0.162% |
| 5 | 0.522% | 0.98% |
| 10 | 1.337% | 2.459% |
| 15 | 2.522% | 4.826% |
| 20 | 4.316% | 8.193% |
Relationships between endpoints
↥Index endpoint: L12_NONIONRADISKINNAS – Other and unspecified skin changes due to chronic exposure to nonionizing radiation
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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