No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
402 |
4. Check minimum number of eventsNone |
402 |
5. Include endpointsNone |
402 |
6. Filter based on genotype QC (FinnGen only) |
402 |
Control definitions (FinnGen only)
- Control exclude
- L12_DERMATITISECZEMA
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- L28
- Name in latin
- Alia prurigo
Similar endpoints
↥List of similar endpoints to
Other prurigo
based on the number of shared cases.
Similar with more cases:
- Lichen simplex chronicus and prurigo
- Dermatitis and eczema
- Diseases of the skin and subcutaneous tissue
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 2946 | 1765 | 1152 |
| Only index persons | 2609 | 1611 | 998 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.04 | 0.05 | 0.03 |
| Only index persons | 0.05 | 0.06 | 0.04 |
| Median age at first event (years) | |||
| Whole population | 55.84 | 55.10 | 56.77 |
| Only index persons | 54.78 | 54.34 | 55.49 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 402 | 255 | 147 |
| Unadjusted period prevalence (%) | 0.08 | 0.09 | 0.06 |
| Median age at first event (years) | 55.66 | 53.90 | 58.70 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 356
- Matched controls
- 3560
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
L28.2
ICD-10 Finland
Other prurigo
4503599627370496.0
323.0
342
*
L30.9
ICD-10 Finland
Dermatitis, unspecified
13.5
78.0
151
184
D07AC01
ATC
betamethasone; topical
7.8
69.4
227
652
E0000UV
ATC
NA
7.8
69.2
248
812
L29.9
ICD-10 Finland
Pruritus, unspecified
51.1
56.2
67
16
L20.0
ICD-10 Finland
Besnier prurigo
+∞
52.4
49
*
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
10.9
52.2
108
136
L28.1
ICD-10 Finland
Prurigo nodularis
576.0
51.8
50
*
D07AC13
ATC
mometasone; topical
6.0
50.5
185
544
D07AD01
ATC
clobetasol; topical
8.1
50.4
130
237
L20.9
ICD-10 Finland
Atopic dermatitis, unspecified
+∞
46.9
44
*
D07AB02
ATC
hydrocortisone butyrate; topical
5.5
45.6
181
567
D07BB04
ATC
hydrocortisone butyrate and antiseptics; topical
8.1
41.1
101
165
E000001
ATC
NA
5.6
39.0
136
353
L29.8
ICD-10 Finland
Other pruritus
78.9
37.9
42
6
D07AB08
ATC
desonide; topical
7.4
31.9
82
139
R06AE07
ATC
cetirizine; oral
3.8
31.7
215
1012
L28.0
ICD-10 Finland
Lichen simplex chronicus
120.8
31.2
33
*
E000002
ATC
NA
6.4
30.1
86
168
D09AB01
ATC
zinc bandage without supplements; topical
29.0
29.1
39
15
D07BC01
ATC
betamethasone and antiseptics; topical
6.0
26.1
78
159
R06AX22
ATC
ebastine; oral
4.5
26.1
108
316
WXQ27
NOMESCO Finland
UVB narrow spectrum light therapy
101.0
26.0
28
*
H02AB06
ATC
prednisolone; systemic
3.2
24.6
209
1086
XQ800
NOMESCO Finland
Prick test
8.4
23.8
54
74
D07BA04
ATC
hydrocortisone and antiseptics; topical
5.5
23.1
73
158
R06AE09
ATC
levocetirizine; oral
4.5
21.8
86
236
Z01.5
ICD-10 Finland
Diagnostic skin and sensitization tests
6.7
21.7
58
101
XQ802
NOMESCO Finland
Epicutan test
30.2
21.3
28
10
D02AE01
ATC
carbamide; topical
7.0
20.7
53
87
L30.3
ICD-10 Finland
Infective dermatitis
29.0
20.3
27
10
J01DB01
ATC
cefalexin; oral
4.0
19.7
317
2387
D07CC01
ATC
betamethasone and antibiotics; topical
4.1
18.7
80
234
R06AX27
ATC
desloratadine; oral
3.1
18.2
129
558
D07AA02
ATC
hydrocortisone; topical
4.1
17.4
73
209
TQW80
NOMESCO Finland
Local dermatologic skincare
15.3
16.6
27
19
R06AX13
ATC
loratadine; oral
3.6
16.1
81
270
E000007
ATC
NA
7.6
16.1
38
55
E000006
ATC
NA
5.7
16.0
47
92
S18
ICPC
Laceration/cut
2.5
15.5
175
981
L30.0
ICD-10 Finland
Nummular dermatitis
12.7
14.3
25
21
N05CF01
ATC
zopiclone; oral
2.5
13.7
148
796
L20
ICD-10 Finland
Atopic dermatitis
+∞
13.6
13
*
69820
ICD-8 Finland
Pruritus and related conditions, Prurigo
+∞
13.6
13
*
D02AX
ATC
Other emollients and protectives
9.9
13.2
26
28
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
3.4
13.2
71
246
N05BB01
ATC
hydroxyzine; systemic
5.0
12.9
42
93
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.3
12.8
176
1055
L20.8
ICD-10 Finland
Other atopic dermatitis
+∞
12.6
12
*
317
Kela drug reimbursment
Topical pimecrolimus and tacrolimus
+∞
12.6
12
*
D01AC20
ATC
imidazoles/triazoles in combination with corticosteroids; topical
2.6
12.3
104
485
L50.3
ICD-10 Finland
Dermatographic urticaria
15.3
11.9
19
13
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.4
11.8
128
678
H02AB07
ATC
prednisone; oral
3.1
11.6
70
264
E000003
ATC
NA
7.0
11.5
28
43
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
2.3
11.5
146
830
J01FF01
ATC
clindamycin; systemic
2.4
11.4
113
570
A02BC05
ATC
esomeprazole; systemic
2.2
11.3
159
949
D07XC01
ATC
betamethasone, combinations; topical
3.4
11.3
58
194
L30.8
ICD-10 Finland
Other specified dermatitis
16.7
10.4
16
10
B86
ICD-10 Finland
Scabies
10.0
10.4
20
21
N02AX02
ATC
tramadol; systemic, rectal
2.1
10.3
166
1036
A46
ICD-10 Finland
Erysipelas
2.9
10.1
64
246
J01DA01
ATC
[U] cefalexin; systemic
2.1
10.1
239
1750
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
2.7
10.0
73
306
N03AX16
ATC
pregabalin; oral
2.3
9.9
106
550
Z49.1
ICD-10 Finland
Extracorporeal dialysis
13.9
9.8
16
12
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
2.1
9.7
173
1120
S02
ICPC
Pruritus
6.2
9.5
25
43
H02AB04
ATC
methylprednisolone; systemic
2.7
9.5
70
296
R03AC02
ATC
salbutamol; inhalant
2.0
9.4
195
1334
L50.9
ICD-10 Finland
Urticaria, unspecified
6.6
9.2
23
37
UJF30
NOMESCO Finland
Ileoscopy through colon
3.3
9.0
45
148
L73.8
ICD-10 Finland
Other specified follicular disorders
24.7
9.0
12
5
M25.5
ICD-10 Finland
Pain in joint
2.1
8.6
111
621
SPAT1148
SPAT
Treatment of chronic ulcer or burn
2.8
8.6
59
238
TK800
NOMESCO Finland
Hemodialysis
7.7
8.6
19
26
A02BC03
ATC
lansoprazole; oral
2.1
8.6
117
672
XQ848
NOMESCO Finland
Dermatological photography
7.0
8.5
20
30
69100
ICD-8 Finland
Infantile eczema and related conditions, Eczema atopicum. Prurigo Besnier. Eczema pruriginosum allergicum
+∞
8.4
8
*
TPH04
NOMESCO Finland
Cathetrisation of vein
2.2
8.3
89
459
PG1DE
NOMESCO Finland
Other extensive ultrasound examination of artery
4.6
8.1
27
62
R50.9
ICD-10 Finland
Fever, unspecified
2.6
8.1
61
262
138
Kela drug reimbursment
Severe anaemia associated with chronic renal failure
7.5
8.1
18
25
J45.9
ICD-10 Finland
Asthma, unspecified
2.4
8.1
73
346
SPAT1263
SPAT
Sampling
1.9
8.1
160
1054
NK6QA
NOMESCO Finland
Measurement of bone density from tow or more locations with X-ray
3.5
7.8
35
106
R03DC03
ATC
montelukast; oral
2.5
7.7
64
289
N02BE01
ATC
paracetamol; systemic, rectal
2.3
7.7
306
2595
S29
ICPC
Skin symptom/complaint other
2.4
7.7
72
344
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
2.5
7.7
60
262
N06AA12
ATC
doxepin; systemic
3.6
7.7
33
97
L21.8
ICD-10 Finland
Other seborrhoeic dermatitis
25.6
7.6
10
*
A02BC02
ATC
pantoprazole; systemic
1.9
7.5
233
1784
WX002
NOMESCO Finland
Sedation and analgesia
2.2
7.3
84
443
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
1.9
7.3
153
1020
S76
ICPC
Skin infection other
4.2
7.2
26
65
C08CA01
ATC
amlodipine; oral
1.9
7.2
130
822
R05
ICD-10 Finland
Cough
2.2
7.2
74
372
137
Kela drug reimbursment
Uraemia requiring dialysis
30.7
7.2
9
*
Z03.89
ICD-10 Finland
Observation for other suspected diseases and conditions
2.7
7.0
50
206
A10AB04
ATC
insulin lispro; parenteral (insulins and analog. for injection, fast-acting)
4.7
6.9
22
49
R21
ICD-10 Finland
Rash and other nonspecific skin eruption
4.3
6.8
24
59
L04AX01
ATC
azathioprine; systemic
4.0
6.8
26
69
R06.0
ICD-10 Finland
Dyspnoea
2.0
6.8
95
542
L04AX03
ATC
methotrexate; systemic (immunosuppressants)
2.8
6.8
43
166
J01AA02
ATC
doxycycline; systemic
1.9
6.8
272
2234
B05DB
ATC
Hypertonic solutions
40.8
6.8
8
*
B05DA
ATC
Isotonic solutions
40.8
6.8
8
*
J01CF05
ATC
flucloxacillin; systemic
4.8
6.7
21
46
R05DA20
ATC
opium alkaloids and derivatives - combinations
2.0
6.7
102
601
N05BA04
ATC
oxazepam; oral
2.0
6.7
99
579
J02AC01
ATC
fluconazole; systemic
1.8
6.6
147
992
5612
FHL
Local excisions and / or perforations of relapsing varicose veins
8.9
6.6
13
15
L50.8
ICD-10 Finland
Other urticaria
10.3
6.6
12
12
NH1AA
NOMESCO Finland
Ankle X-ray examination without contrast
3.3
6.5
31
100
C03CA01
ATC
furosemide; systemic
1.9
6.4
111
685
N18.9
ICD-10 Finland
Chronic kidney disease, unspecified
3.5
6.4
28
84
C08CA13
ATC
lercanidipine; oral
2.4
6.4
55
252
TPH90
NOMESCO Finland
Removal of fixed intravenous catheter
9.5
6.3
12
13
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
1.8
6.3
146
994
D05BB02
ATC
acitretin; oral
7.2
6.3
14
20
J06.9
ICD-10 Finland
Acute upper respiratory infection, unspecified
1.8
6.3
143
969
N06AX11
ATC
mirtazapine; oral
1.9
6.3
120
767
L98.1
ICD-10 Finland
Factitial dermatitis
+∞
6.3
6
*
J04BA02
ATC
dapsone; oral
27.2
6.3
8
*
R01AD09
ATC
mometasone; nasal
1.8
6.2
154
1068
J01FA06
ATC
roxithromycin; oral
1.8
6.2
146
996
J01DA09
ATC
[U] cefadroxil; inhalant, oral
1.9
6.2
102
619
N03AX12
ATC
gabapentin; oral
2.2
6.2
61
300
P01BA02
ATC
hydroxychloroquine; oral
2.8
6.1
37
140
S97
ICPC
Chronic ulcer skin
3.8
6.1
24
66
L04AA06
ATC
mycophenolic acid; systemic
8.8
6.1
12
14
A12AA04
ATC
calcium carbonate; oral
8.8
6.1
12
14
A11CC03
ATC
alfacalcidol; systemic
5.7
6.1
16
29
123
Kela drug reimbursment
Chronic disorders of vitamin D metabolism
6.2
6.1
15
25
Z01.0
ICD-10 Finland
Examination of eyes and vision
2.2
6.0
62
310
J20.9
ICD-10 Finland
Acute bronchitis, unspecified
2.1
6.0
70
370
G62.9
ICD-10 Finland
Polyneuropathy, unspecified
4.9
6.0
18
38
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
231
1354
2.66
20.37
7.0
4.2
35.3
35.5
g/l
0.21
221
1270
241
1501
2.51
17.84
10.5
5.4
26.5
28.0
%
1.33
235
1390
238
1479
2.49
17.62
10.0
5.2
57.3
57.3
%
0.00
233
1383
152
784
2.51
16.74
2.6
2.1
3.1
3.1
mg/l
0.02
131
666
137
706
2.43
14.81
1.4
1.3
1.2
1.5
u/ml
0.24
29
195
263
1846
2.23
12.91
12.2
8.6
4.2
4.1
e9/l
0.33
242
1612
117
594
2.37
12.82
4.0
3.9
278.2
377.0
ng/l
0.19
94
483
63
236
2.98
12.73
15.6
6.5
11.4
9.9
mmol/l
0.90
58
224
63
237
2.97
12.63
3.2
3.1
305.6
185.5
ng/l
0.70
58
214
214
1402
2.13
12.33
4.2
2.7
130.4
120.1
ug/l
0.19
204
1279
97
463
2.44
12.13
4.0
2.1
2.3
2.3
g/l
0.25
91
420
234
1610
2.08
11.55
11.6
6.2
1.2
1.2
mmol/l
0.50
210
1355
161
977
2.08
11.06
3.6
2.3
53.7
55.2
u/l
0.26
150
903
59
236
2.76
10.51
5.5
3.4
140.3
76.0
ng/l
3.04
52
210
57
224
2.80
10.50
1.9
1.5
—
—
—
0
0
201
1341
2.00
10.45
3.0
2.2
80.3
77.4
nmol/l
0.58
186
1177
89
435
2.34
10.43
4.5
2.2
20.7
22.7
%
0.67
75
376
213
1463
1.97
10.05
9.9
5.3
1.2
1.2
mmol/l
0.13
194
1322
234
1666
1.97
9.87
8.3
5.9
10.7
10.9
umol/l
0.17
225
1577
34
104
3.48
9.54
1.2
3.1
2.7
3.2
g/l
1.45
28
77
128
750
2.04
9.39
1.7
1.5
22.2
21.1
nmol/l
0.35
117
625
193
1307
1.92
9.25
2.3
1.9
93.8
97.0
pmol/l
0.41
108
671
33
102
3.44
9.11
1.2
3.1
10.4
10.0
g/l
0.18
28
85
35
113
3.30
9.03
1.2
3.0
—
—
—
0
0
35
113
3.30
9.03
1.2
3.0
3.7
3.6
g/l
0.08
28
76
35
113
3.30
9.03
1.2
3.0
7.2
7.5
g/l
0.44
28
80
302
2399
2.04
8.71
6.7
3.8
15.4
12.0
mm/h
3.02
294
2200
72
346
2.32
8.68
2.5
2.6
5.3
9.0
umol/l
2.06
60
296
306
2448
2.05
8.57
12.5
7.1
78.1
78.4
u/l
0.05
298
2280
249
1870
1.87
8.31
6.8
4.1
7.1
6.7
mmol/l
2.18
235
1742
128
780
1.94
8.23
4.3
2.5
8340.0
10165.0
umol/l
0.12
110
672
305
2457
2.00
8.10
4.8
3.9
14.8
14.8
pmol/l
0.08
290
2203
54
240
2.44
7.72
1.3
3.1
66.7
66.6
g/l
0.03
49
209
20
49
4.24
7.63
1.8
1.3
100.4
115.7
u/ml
—
8
7
61
292
2.28
7.38
2.0
1.8
311.5
379.2
nmol/l
2.04
55
267
160
1084
1.79
7.17
3.5
3.4
2.3
2.4
mmol/l
0.66
140
947
147
972
1.81
7.14
2.8
2.0
209.0
255.2
u/l
0.18
139
917
90
509
1.99
7.07
2.4
1.8
—
—
—
0
0
145
960
1.80
6.99
3.4
3.0
4347.3
1376.8
ng/l
1.17
130
817
170
1186
1.75
6.80
4.3
3.0
—
—
—
0
0
141
940
1.77
6.56
4.8
4.0
15.8
6.4
mg/mmol
0.83
104
570
27
91
3.11
6.51
1.3
1.3
280.1
328.3
ug/g
0.59
19
53
6
0
+∞
6.26
6.8
0.0
—
—
—
0
0
342
2962
2.04
6.13
6.0
4.7
1.8
2.3
mu/l
0.66
334
2684
114
730
1.78
6.01
1.8
1.6
1.8
1.2
mg/l
0.35
94
570
89
535
1.85
5.74
1.3
1.3
20.3
36.1
iu/ml
1.96
19
180
32
130
2.59
5.52
1.5
2.0
1.5
1.4
g/l
0.20
27
114
18
52
3.58
5.52
1.4
1.2
220.0
252.4
u/ml
0.15
13
28
72
411
1.92
5.43
33.3
21.6
1.4
1.3
inr
0.26
17
50
246
1972
1.64
5.35
3.0
3.0
—
—
—
0
0
98
624
1.75
5.19
2.0
1.7
1080.2
1222.1
nmol/l
0.82
80
454
21
70
3.11
5.18
2.5
1.8
4963.4
23738.9
e6/l
1.37
13
54
16
45
3.66
5.10
1.4
1.3
—
—
—
0
0
358
3213
2.04
4.89
26.5
13.5
23.3
22.6
mg/l
0.16
309
2539
87
545
1.76
4.85
2.8
2.5
0.8
1.1
e6/l
0.59
48
295
112
753
1.68
4.83
2.8
2.2
—
—
—
0
0
104
686
1.70
4.82
1.9
1.7
90217882.5
442.1
pmol/l
0.49
92
564
83
520
1.75
4.61
2.9
2.7
2.5
2.2
e6/l
0.14
42
272
27
111
2.54
4.57
2.3
1.7
—
—
—
0
0
119
824
1.63
4.55
1.8
1.6
1.4
1.3
mmol/l
0.61
113
674
17
54
3.24
4.54
1.5
1.2
—
—
—
0
0
130
921
1.61
4.52
4.0
2.9
0.4
0.6
e6/l
0.64
100
681
28
118
2.48
4.51
2.8
1.8
—
—
—
0
0
62
358
1.87
4.50
1.9
1.8
—
—
—
0
0
92
598
1.70
4.47
2.7
2.9
2.5
2.5
mmol/l
0.05
77
529
24
94
2.65
4.47
2.0
1.5
0.4
0.0
iu/ml
—
5
21
12
30
4.09
4.46
1.2
1.2
—
—
—
0
0
62
359
1.86
4.46
1.8
1.8
—
—
—
0
0
23
90
2.65
4.30
3.6
2.8
—
—
—
0
0
24
102
2.44
3.82
1.7
1.4
—
—
—
0
0
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
21
85
2.55
3.69
2.3
2.3
0.3
0.3
u/ml
0.10
12
47
21
86
2.52
3.61
1.7
2.4
10.0
11.3
mg/l
0.30
21
77
15
51
3.02
3.61
1.2
1.3
—
—
—
0
0
360
3308
1.84
3.54
29.7
15.6
4.0
4.0
mmol/l
0.18
355
3216
77
507
1.64
3.53
1.4
1.3
3.7
11.2
u/ml
1.66
28
195
17
64
2.73
3.44
1.5
1.2
—
—
—
0
0
17
64
2.73
3.44
1.5
1.2
—
—
—
0
0
7
10
7.10
3.37
1.9
1.3
8.4
8.2
ug/l
—
7
10
29
142
2.12
3.36
13.6
2.9
23.8
24.2
mmol/l
0.27
24
128
19
77
2.54
3.35
2.4
1.4
—
—
—
0
0
31
159
2.03
3.19
6.4
7.4
24.9
24.7
mmol/l
0.14
31
145
18
73
2.53
3.17
1.2
1.5
—
—
—
0
0
21
92
2.35
3.16
2.0
1.2
—
—
—
0
0
7
12
5.92
3.03
2.1
1.7
—
—
—
0
0
7
12
5.92
3.03
2.1
1.7
—
—
—
0
0
7
12
5.92
3.03
2.1
1.7
—
—
—
0
0
5
5
10.10
2.98
1.0
1.2
—
—
—
0
0
184
1501
1.42
2.96
4.5
3.9
—
—
—
0
0
26
129
2.09
2.93
6.0
4.3
1.6
1.6
%
0.12
26
120
40
232
1.80
2.89
3.0
3.1
73.1
62.4
ml/min/173m2
1.00
20
92
21
96
2.25
2.88
1.5
1.7
—
—
—
0
0
20
91
2.26
2.78
1.5
1.2
—
—
—
0
0
17
72
2.42
2.76
1.4
1.1
—
—
—
0
0
46
282
1.71
2.76
8.7
3.0
5.7
5.7
kpa
0.01
46
272
54
347
1.64
2.72
5.9
6.2
1.1
1.2
mmol/l
0.10
44
271
53
339
1.65
2.72
6.1
3.3
—
—
—
0
0
16
67
2.45
2.66
4.9
2.4
15.1
15.8
%
—
10
35
16
67
2.45
2.66
3.2
2.2
120.1
129.2
g/l
0.78
11
52
11
38
2.95
2.60
1.5
1.5
—
—
—
0
0
45
279
1.69
2.60
9.0
3.1
1.9
2.0
mmol/l
0.07
39
219
36
212
1.77
2.49
1.1
1.2
193.9
154.2
iu/ml
0.22
14
82
7
16
4.43
2.48
2.4
2.1
—
—
—
0
0
14
57
2.51
2.47
4.3
2.7
3.8
4.2
e9/l
0.37
14
57
17
77
2.26
2.41
1.6
1.3
—
—
—
0
0
76
544
1.49
2.40
1.5
1.5
—
—
—
0
0
11
40
2.80
2.39
2.3
1.3
—
—
—
0
0
5
8
6.31
2.38
1.6
3.1
—
—
—
0
0
5
8
6.31
2.38
2.0
1.1
—
—
—
0
0
7
17
4.17
2.37
1.3
1.7
746.1
372.8
e6/l
—
7
12
7
18
3.94
2.26
2.1
1.6
—
—
—
0
0
7
18
3.94
2.26
2.1
1.6
—
—
—
0
0
7
18
3.94
2.26
2.1
1.6
—
—
—
0
0
7
18
3.94
2.26
2.1
1.6
—
—
—
0
0
239
2094
1.35
2.25
5.0
2.9
47.4
45.4
u/l
0.19
228
1958
14
60
2.38
2.24
5.1
2.7
56.6
56.9
%
0.02
14
60
14
60
2.38
2.24
1.6
1.6
—
—
—
0
0
12
49
2.49
2.12
1.5
1.6
—
—
—
0
0
321
2962
1.42
2.08
7.7
5.7
41.1
39.9
mmol/mol
1.12
308
2756
7
20
3.54
2.06
1.4
1.3
—
—
—
0
0
7
20
3.54
2.06
1.4
1.3
—
—
—
0
0
19
97
2.01
2.03
2.2
1.4
1.1
1.2
g/l
0.48
19
92
16
77
2.12
1.99
2.3
2.8
49.1
62.8
ug/min
—
10
46
32
196
1.69
1.97
1.8
1.4
—
—
—
0
0
334
3115
1.43
1.93
6.0
4.5
6.0
5.9
mmol/l
0.24
313
2831
18
92
2.00
1.93
4.2
3.1
25.5
24.8
mmol/l
0.24
13
82
13
58
2.28
1.93
2.4
1.5
—
—
—
0
0
183
1566
1.31
1.92
4.7
3.6
0.0
0.0
estimate
0.00
42
304
30
183
1.69
1.88
1.7
1.7
—
—
—
0
0
8
28
2.89
1.87
1.5
1.1
—
—
—
0
0
6
17
3.57
1.84
1.5
1.2
—
—
—
0
0
6
17
3.57
1.84
1.5
1.2
—
—
—
0
0
183
1574
1.30
1.83
6.7
4.8
0.0
0.0
estimate
0.50
43
300
6
18
3.37
1.75
1.8
1.4
0.8
1.1
g/l
—
6
18
49
343
1.49
1.75
2.8
2.0
—
—
—
0
0
124
1018
1.32
1.73
5.6
3.0
28.9
31.4
u/l
0.81
119
969
7
24
2.95
1.73
1.0
1.0
—
—
—
0
0
16
82
1.99
1.72
3.0
1.6
—
—
—
0
0
149
1263
1.29
1.62
4.8
3.7
64.0
38.6
ng/l
0.58
106
906
5
14
3.60
1.62
1.0
1.1
—
—
—
0
0
5
14
3.60
1.62
1.0
1.1
—
—
—
0
0
11
50
2.23
1.58
1.0
1.3
0.4
0.6
nmol/l
1.54
11
45
183
1597
1.27
1.56
5.0
3.6
0.1
0.0
estimate
0.40
39
290
10
44
2.31
1.54
1.9
1.3
—
—
—
0
0
10
44
2.31
1.54
1.9
1.3
—
—
—
0
0
10
44
2.31
1.54
1.9
1.3
—
—
—
0
0
10
44
2.31
1.54
1.9
1.3
—
—
—
0
0
36
243
1.53
1.53
6.9
2.5
5.3
4.4
kpa
1.27
36
232
44
311
1.47
1.51
2.8
1.9
—
—
—
0
0
22
132
1.71
1.49
4.3
1.7
—
—
—
0
0
10
45
2.25
1.47
1.5
1.5
—
—
—
0
0
10
45
2.25
1.47
1.9
1.3
—
—
—
0
0
10
45
2.25
1.47
1.9
1.3
—
—
—
0
0
40
279
1.48
1.47
9.9
3.8
1.2
1.2
mmol/l
2.13
34
244
15
80
1.91
1.46
1.5
1.6
2.6
6.8
iu/l
—
9
21
16
275
0.56
1.45
1.4
1.6
—
—
—
0
0
9
39
2.34
1.44
1.2
1.1
—
—
—
0
0
7
29
2.44
1.40
2.6
1.6
—
—
—
0
0
7
29
2.44
1.40
1.7
1.2
—
—
—
0
0
7
29
2.44
1.40
2.6
1.6
—
—
—
0
0
7
29
2.44
1.40
2.6
1.6
—
—
—
0
0
308
2889
1.28
1.31
26.7
14.5
38.6
39.8
%
1.44
226
2083
6
24
2.52
1.31
1.7
3.0
—
—
—
0
0
8
34
2.38
1.30
2.9
1.6
—
—
—
0
0
8
34
2.38
1.30
2.4
1.4
60.5
17.8
ug/l
—
8
34
356
3412
1.38
1.25
18.3
10.0
24.9
25.3
u/l
0.26
349
3290
338
3215
1.32
1.25
5.9
4.9
2.6
2.8
mmol/l
1.51
319
2960
6
26
2.33
1.19
1.0
1.5
—
—
—
0
0
6
26
2.33
1.19
1.2
1.2
—
—
—
0
0
6
26
2.33
1.19
1.0
1.1
—
—
—
0
0
6
26
2.33
1.19
1.0
1.1
—
—
—
0
0
8
38
2.13
1.19
2.9
1.5
—
—
—
0
0
10
50
2.03
1.17
1.4
1.2
11.5
24.4
u/l
—
10
40
8
39
2.07
1.16
1.4
1.6
—
—
—
0
0
330
3141
1.28
1.12
5.6
4.4
4.6
4.7
mmol/l
1.30
312
2915
13
73
1.81
1.12
1.4
1.4
—
—
—
0
0
319
3027
1.26
1.09
24.0
12.8
76.1
80.2
ml/min/173m2
1.91
278
2502
5
21
2.40
1.09
1.4
1.2
—
—
—
0
0
65
522
1.29
1.07
1.4
1.4
—
—
—
0
0
14
82
1.73
1.06
2.7
1.5
—
—
—
0
0
328
3127
1.27
1.05
5.4
4.3
1.5
1.5
mmol/l
1.11
310
2889
318
3024
1.25
1.02
5.0
3.9
1.3
1.3
mmol/l
0.77
297
2781
5
23
2.19
0.98
1.8
1.7
—
—
—
0
0
17
108
1.60
0.98
1.1
1.1
—
—
—
0
0
17
109
1.58
0.95
1.1
1.1
—
—
—
0
0
50
395
1.30
0.94
5.0
4.6
32.7
32.3
%
0.09
38
260
6
27
2.24
0.94
1.0
1.1
—
—
—
0
0
6
27
2.24
0.94
1.0
1.1
—
—
—
0
0
6
27
2.24
0.94
1.0
1.1
—
—
—
0
0
14
88
1.61
0.85
2.0
1.4
—
—
—
0
0
6
32
1.89
0.82
1.0
1.0
—
—
—
0
0
7
40
1.76
0.71
1.0
1.1
—
—
—
0
0
5
26
1.93
0.71
1.2
1.1
—
—
—
0
0
5
26
1.93
0.71
1.2
1.1
—
—
—
0
0
24
178
1.37
0.70
4.3
1.8
—
—
—
0
0
43
348
1.26
0.70
3.3
4.2
8.7
47.6
ug/l
0.98
34
294
8
49
1.65
0.62
1.0
1.1
—
—
—
0
0
6
36
1.68
0.57
3.2
2.2
—
—
—
0
0
9
133
0.67
0.52
1.1
1.5
—
—
—
0
0
22
171
1.30
0.51
1.0
1.0
—
—
—
0
0
23
181
1.29
0.49
1.5
1.3
—
—
—
0
0
0
15
0.00
0.41
0.0
1.5
—
—
—
0
0
5
34
1.48
0.40
3.6
3.8
—
—
—
0
0
11
80
1.39
0.39
1.5
1.3
—
—
—
0
0
6
41
1.47
0.36
1.5
1.4
—
—
—
0
0
91
840
1.11
0.35
4.4
4.9
2.9
3.0
ug/l
0.05
81
737
13
100
1.31
0.34
1.5
1.4
—
—
—
0
0
23
192
1.21
0.33
2.6
2.1
11.2
13.0
nmol/l
0.47
18
173
7
98
0.71
0.31
1.9
2.0
—
—
—
0
0
82
880
0.91
0.28
6.2
3.8
0.0
0.0
estimate
0.80
41
297
10
77
1.31
0.26
1.3
1.3
—
—
—
0
0
44
486
0.89
0.26
2.9
3.1
0.5
0.8
ug/l
3.25
31
312
41
372
1.11
0.23
8.0
6.7
—
—
—
0
0
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
0
11
0.00
0.21
0.0
1.3
—
—
—
0
0
0
11
0.00
0.21
0.0
1.3
—
—
—
0
0
0
10
0.00
0.21
0.0
1.3
—
—
—
0
0
0
10
0.00
0.21
0.0
1.2
—
—
—
0
0
21
183
1.16
0.20
3.9
2.7
0.2
0.2
e6/l
0.08
21
175
0
14
0.00
0.20
0.0
1.5
—
—
—
0
0
6
51
1.18
0.19
1.5
1.4
—
—
—
0
0
9
78
1.16
0.15
1.1
1.1
—
—
—
0
0
5
47
1.06
0.09
1.0
1.5
—
—
—
0
0
69
666
1.04
0.09
3.8
4.2
21.4
21.2
%
0.03
27
303
6
57
1.05
0.08
1.5
1.7
—
—
—
0
0
10
93
1.08
0.02
1.6
1.5
—
—
—
0
0
0
9
0.00
0.00
0.0
1.3
—
—
—
0
0
124
1240
1.00
0.00
5.4
3.7
—
—
—
0
0
7
77
0.91
0.00
2.4
1.7
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
(3002348) Coagulation factor XII activity actual/normal in Platelet poor plasma by Coagulation assay
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
2.2
—
1.3
—
0
6
0
8
0.00
0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
(3011547) Coagulation factor VII activity actual/normal in Platelet poor plasma by Coagulation assay
0
8
0.00
0.00
0.0
1.0
—
117.0
—
0
8
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
7
0.00
0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.8
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.5
—
—
—
0
0
0
7
0.00
0.00
0.0
1.3
—
—
—
0
0
5
52
0.96
0.00
1.8
1.8
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint L12_PRURIGONAS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_PRURIGONAS | 1.386 [1.18, 1.63] | < 0.001 |
| Birth year | 0.995 [0.99, 1.0] | 0.214 |
During the follow-up period (1.1.1998 — 31.12.2019), 337 out of 1532 females with L12_PRURIGONAS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_PRURIGONAS | 1.635 [1.33, 2.01] | < 0.001 |
| Birth year | 0.984 [0.97, 0.99] | 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 342 out of 1002 males with L12_PRURIGONAS died.
Mortality risk
Mortality risk for people of age
years, who have L12_PRURIGONAS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.094% | 0.339% |
| 5 | 0.64% | 1.753% |
| 10 | 1.935% | 4.381% |
| 15 | 3.65% | 8.135% |
| 20 | 6.816% | 13.54% |
Relationships between endpoints
↥Index endpoint: L12_PRURIGONAS – Other prurigo
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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