No definition available.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519972 |
1. Apply sex-specific ruleNone |
519972 |
2. Check conditionsNone |
519972 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
418 |
4. Check minimum number of eventsNone |
418 |
5. Include endpointsNone |
418 |
6. Filter based on genotype QC (FinnGen only) |
408 |
Control definitions (FinnGen only)
- Control exclude
- L12_DERMATITISECZEMA
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- L28
- Name in latin
- Alia prurigo
Similar endpoints
↥List of similar endpoints to
Other prurigo
based on the number of shared cases.
Similar with more cases:
- Lichen simplex chronicus and prurigo
- Dermatitis and eczema
- Diseases of the skin and subcutaneous tissue
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 2946 | 1765 | 1152 |
| Only index persons | 2609 | 1611 | 998 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.04 | 0.05 | 0.03 |
| Only index persons | 0.05 | 0.06 | 0.04 |
| Median age at first event (years) | |||
| Whole population | 55.84 | 55.10 | 56.77 |
| Only index persons | 54.78 | 54.34 | 55.49 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 408 | 261 | 147 |
| Unadjusted period prevalence (%) | 0.08 | 0.09 | 0.07 |
| Median age at first event (years) | 55.75 | 53.92 | 59.01 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 418
- Matched controls
- 4180
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
L28.2
ICD-10 Finland
Other prurigo
4503599627370496.0
307.7
403
*
L30.9
ICD-10 Finland
Dermatitis, unspecified
12.1
138.0
185
258
L29.9
ICD-10 Finland
Pruritus, unspecified
48.5
132.5
79
20
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
12.7
115.4
133
148
D07AC01
ATC
betamethasone; topical
8.3
100.7
285
861
E0000UV, ,
ATC
7.9
91.6
300
1018
D07AD01
ATC
clobetasol; topical
8.0
91.6
168
324
D07BB04
ATC
hydrocortisone butyrate and antiseptics; topical
7.9
77.8
133
234
D09AB01
ATC
zinc bandage without supplements; topical
41.9
73.5
45
12
D07AC13
ATC
mometasone; topical
5.9
72.4
214
632
D07AB02
ATC
hydrocortisone butyrate; topical
5.5
67.0
214
667
L28.1
ICD-10 Finland
Prurigo nodularis
709.2
63.6
61
*
L20.0
ICD-10 Finland
Besnier prurigo
+∞
63.1
59
*
E000002, ,
ATC
7.4
59.4
100
170
E000001, ,
ATC
5.6
59.2
151
383
D07BA04
ATC
hydrocortisone and antiseptics; topical
7.6
54.0
86
137
L20.9
ICD-10 Finland
Atopic dermatitis, unspecified
+∞
53.3
50
*
D07AB08
ATC
desonide; topical
6.7
50.5
93
172
R06AE07
ATC
cetirizine; oral
4.4
48.7
265
1175
TQW80
NOMESCO Finland
Local dermatologic skincare
19.8
47.9
38
21
L29.8
ICD-10 Finland
Other pruritus
94.5
46.0
50
6
R06AX22
ATC
ebastine; oral
4.5
41.1
127
366
D07BC01
ATC
betamethasone and antiseptics; topical
5.4
40.1
92
207
L28.0
ICD-10 Finland
Lichen simplex chronicus
401.3
37.6
37
*
XQ800
NOMESCO Finland
Prick test
7.4
37.2
58
89
R06AX27
ATC
desloratadine; oral
3.7
34.9
165
633
Z01.5
ICD-10 Finland
Diagnostic skin and sensitization tests
5.7
31.5
64
128
D02AX
ATC
Other emollients and protectives
11.9
30.6
32
29
D02AE01
ATC
carbamide; topical
6.1
29.5
55
101
D07AA02
ATC
hydrocortisone; topical
4.3
29.3
90
253
H02AB06
ATC
prednisolone; systemic
3.1
28.4
254
1384
WXQ27
NOMESCO Finland
UVB narrow spectrum light therapy
69.1
28.4
32
5
L30.0
ICD-10 Finland
Nummular dermatitis
11.5
28.1
30
28
R06AE09
ATC
levocetirizine; oral
3.7
26.1
98
316
D07CC01
ATC
betamethasone and antibiotics; topical
3.8
24.0
87
273
E000006, ,
ATC
5.1
22.9
52
114
N05BB01
ATC
hydroxyzine; systemic
5.3
22.9
49
102
S02
ICPC
Pruritus
7.7
22.8
33
46
E000007, ,
ATC
6.1
22.6
41
73
XQ802
NOMESCO Finland
Epicutan test
16.6
19.6
31
20
L30.3
ICD-10 Finland
Infective dermatitis
19.4
19.4
29
16
R21
ICD-10 Finland
Rash and other nonspecific skin eruption
5.8
19.4
37
69
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.6
19.0
154
758
D07XC01
ATC
betamethasone; topical
3.5
18.7
71
228
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
3.3
18.2
81
287
J01DB01
ATC
cefalexin; oral
3.9
17.9
375
2886
R06AX13
ATC
loratadine; oral
3.1
17.9
91
349
E000003, ,
ATC
6.1
17.9
32
56
L20
ICD-10 Finland
Atopic dermatitis
+∞
16.8
16
*
N05CF01
ATC
zopiclone; oral
2.4
16.7
172
935
A46
ICD-10 Finland
Erysipelas
3.0
16.7
85
325
XQ848
NOMESCO Finland
Dermatological photography
6.9
16.4
26
40
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
2.4
16.1
178
996
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.3
16.0
225
1393
H02AB04
ATC
methylprednisolone; systemic
3.0
15.9
82
316
L50.3
ICD-10 Finland
Dermatographic urticaria
15.6
15.6
25
17
D01AC20
ATC
imidazoles/triazoles in combination with corticosteroids; topical
2.5
15.3
118
559
N03AX16
ATC
[U] pregabalin
2.5
15.0
125
612
69820
ICD-8 Finland
Pruritus and related conditions, Prurigo
+∞
14.7
14
*
L50.9
ICD-10 Finland
Urticaria, unspecified
5.3
14.5
30
60
S29
ICPC
Skin symptom/complaint other
2.6
14.5
101
454
L30.8
ICD-10 Finland
Other specified dermatitis
12.6
14.3
25
21
J01FF01
ATC
clindamycin; systemic
2.4
14.1
135
702
S18
ICPC
Laceration/cut
2.2
14.1
215
1355
H02AB07
ATC
prednisone; oral
2.8
14.0
79
318
B86
ICD-10 Finland
Scabies
10.6
13.7
26
26
L20.8
ICD-10 Finland
Other atopic dermatitis
+∞
13.6
13
*
L04AX01
ATC
azathioprine; systemic
5.3
13.6
28
56
N02AX02
ATC
tramadol; systemic, rectal
2.2
13.4
201
1251
N18.9
ICD-10 Finland
Chronic kidney disease, unspecified
4.0
13.0
39
106
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
2.6
12.8
83
358
317
Kela drug reimbursment
Topical pimecrolimus and tacrolimus
+∞
12.6
12
*
J01DA01
ATC
[U] cefalexin
2.2
12.4
278
1997
UKC02
NOMESCO Finland
Cystoscopy
2.6
12.0
78
337
J01MA12
ATC
levofloxacin; systemic
2.4
11.8
94
447
A02BC02
ATC
pantoprazole; systemic
2.2
11.5
296
2210
J02AC01
ATC
fluconazole; systemic
2.1
11.5
179
1114
R03AC02
ATC
salbutamol; inhalant
2.0
11.3
246
1722
J45.9
ICD-10 Finland
Asthma, unspecified
2.3
11.1
95
465
Z49.1
ICD-10 Finland
Extracorporeal dialysis
14.4
11.1
18
13
R50.9
ICD-10 Finland
Fever, unspecified
2.5
11.0
76
337
N05BA04
ATC
oxazepam; oral
2.1
11.0
132
742
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
2.0
11.0
196
1275
A02BC05
ATC
esomeprazole; systemic
2.0
10.9
185
1181
Z01.8
ICD-10 Finland
Other specified special examinations
2.3
10.8
104
535
SPAT1255
SPAT
Intravenous administration of medicine
3.4
10.7
40
126
UJF30
NOMESCO Finland
Ileoscopy through colon
2.9
10.7
54
204
A11CC03
ATC
alfacalcidol; systemic
5.6
10.5
20
37
A10AB04
ATC
insulin lispro; parenteral
4.5
10.5
26
61
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
2.0
10.5
198
1308
TK800
NOMESCO Finland
Hemodialysis
8.5
10.5
22
27
TPH04
NOMESCO Finland
Cathetrisation of vein
2.2
10.3
105
551
PG1DE
NOMESCO Finland
Other extensive ultrasound examination of artery
3.8
10.3
32
89
Z03.89
ICD-10 Finland
Observation for other suspected diseases and conditions
2.5
10.3
70
308
J01MA02
ATC
ciprofloxacin; systemic
2.0
10.3
177
1130
Z71.8
ICD-10 Finland
Other specified counselling
2.0
10.2
140
825
L04AA06
ATC
mycophenolic acid; systemic
11.7
10.1
18
16
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
2.3
10.1
91
454
138
Kela drug reimbursment
Severe anaemia associated with chronic renal failure
7.7
9.8
22
30
R06.0
ICD-10 Finland
Dyspnoea
2.1
9.7
128
740
F32.9
ICD-10 Finland
Depressive episode, unspecified
2.6
9.7
62
264
L21.8
ICD-10 Finland
Other seborrhoeic dermatitis
56.3
9.7
11
*
SPAT1148
SPAT
Treatment of chronic ulcer or burn
2.5
9.6
68
305
C08CA13
ATC
lercanidipine; oral
2.4
9.5
76
360
M25.5
ICD-10 Finland
Pain in joint
2.0
9.4
143
870
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
2.3
9.3
79
383
123
Kela drug reimbursment
Chronic disorders of vitamin D metabolism
7.3
9.1
21
30
127
Kela drug reimbursment
Transplant complication
11.8
9.1
16
14
Z03.9
ICD-10 Finland
Observation for suspected disease or condition, unspecified
2.2
9.1
85
429
L73.8
ICD-10 Finland
Other specified follicular disorders
16.0
9.1
14
9
NK6QA
NOMESCO Finland
Measurement of bone density from two or more locations with X-ray
3.1
9.1
39
134
C01CA24
ATC
epinephrine; parenteral
3.4
9.0
33
103
C03CA01
ATC
furosemide; systemic
1.9
9.0
144
889
L04AD02
ATC
tacrolimus; systemic
24.6
9.0
12
5
TPH90
NOMESCO Finland
Removal of fixed intravenous catheter
12.9
8.9
15
12
L28
ICPC
Limited function/disability (L)
2.2
8.9
88
454
J46
ICD-10 Finland
Status asthmaticus
5.1
8.9
19
39
Z71.2
ICD-10 Finland
Person consulting for explanation of investigation findings
2.0
8.9
126
744
Z3231
NOMESCO Finland
Registered nurse
2.0
8.9
128
761
M54.5
ICD-10 Finland
Low back pain
1.9
8.8
155
986
J01FA06
ATC
roxithromycin; oral
1.9
8.8
175
1158
R07.0
ICD-10 Finland
Pain in throat
3.3
8.7
33
105
WX002
NOMESCO Finland
Sedation and analgesia
2.1
8.7
93
495
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
2.3
8.6
69
326
L04AX03
ATC
methotrexate; systemic
2.6
8.5
52
216
N06AX11
ATC
mirtazapine; oral
1.9
8.5
154
986
WX408
NOMESCO Finland
General anesthesy, balanced
2.0
8.5
118
691
R05
ICD-10 Finland
Cough
2.1
8.5
100
552
N06CA01
ATC
amitriptyline and psycholeptics; systemic
2.5
8.5
55
236
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
2.3
8.5
75
370
V03AE03
ATC
lanthanum carbonate; oral
91.8
8.4
9
*
69100
ICD-8 Finland
Infantile eczema and related conditions, Eczema atopicum. Prurigo Besnier. Eczema pruriginosum allergicum
+∞
8.4
8
*
N03AX12
ATC
[U] gabapentin; oral
2.2
8.3
78
394
M79.6
ICD-10 Finland
Pain in limb
1.8
8.3
180
1219
R03DC03
ATC
montelukast; oral
2.2
8.2
79
403
D11
ICPC
Diarrhoea
2.4
8.1
60
274
KH1AE
NOMESCO Finland
Urinary tract ultrasound examination
3.2
8.0
32
105
N06AA12
ATC
doxepin; systemic
3.0
8.0
36
127
J01DA09
ATC
[U] cefadroxil
1.9
7.9
115
682
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
1.8
7.9
174
1180
SPAT1263
SPAT
Sampling
1.8
7.8
183
1261
L40.0
ICD-10 Finland
Psoriasis vulgaris
4.3
7.8
20
48
R13
ICD-10 Finland
Dysphagia
3.0
7.8
36
129
S01GX01
ATC
cromoglicic acid; ophthalmic
2.1
7.8
85
455
D05BB02
ATC
acitretin; oral
7.7
7.7
17
23
L01
ICPC
Neck symptom/complaint
2.2
7.7
74
376
ZXD31
NOMESCO Finland
Major difficulties in performing procedure
4.7
7.7
18
40
N06AA09
ATC
amitriptyline; systemic
2.6
7.7
48
202
ZXE20
NOMESCO Finland
More than three and less than five hours
2.2
7.7
68
335
J01AA02
ATC
doxycycline; systemic
2.0
7.7
323
2651
R01AD09
ATC
mometasone; nasal
1.8
7.5
189
1325
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
3.1
7.5
32
110
Z49.0
ICD-10 Finland
Preparatory care for dialysis
13.7
7.4
12
9
D07CA01
ATC
hydrocortisone and antibiotics; topical
2.3
7.4
61
291
WX892
NOMESCO Finland
Monitored bed care
2.8
7.4
37
139
ZY020
NOMESCO Finland
Telephone, letter or other consultation without direct patient contact
2.8
7.3
36
134
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
2.4
7.2
50
221
320
Kela drug reimbursment
Lanthanum carbonate, sevelamer and sucroferric oxyhydroxide
20.4
7.2
10
5
M10.0
ICD-10 Finland
Idiopathic gout
4.2
7.2
19
47
A01AB09
ATC
miconazole; local oral
2.5
7.2
48
209
J06.9
ICD-10 Finland
Acute upper respiratory infection, unspecified
1.7
7.1
195
1396
J01.0
ICD-10 Finland
Acute maxillary sinusitis
1.9
7.0
100
586
L03
ICPC
Low back symptom/complaint
1.8
7.0
122
763
Z76.0
ICD-10 Finland
Issue of repeat prescription
1.9
7.0
97
563
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
2.4
7.0
50
224
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
2.3
7.0
57
271
S76
ICPC
Skin infection other
3.0
7.0
31
109
A06AD11
ATC
lactulose; oral
2.1
6.9
72
377
A02BA02
ATC
ranitidine; systemic
2.0
6.9
90
512
XG412
NOMESCO Finland
Flow-volume spirometry with bronchospasmolysis
3.2
6.9
28
93
R03BA02
ATC
budesonide; inhalant
2.0
6.9
81
444
R05DA20
ATC
opium alkaloids and derivatives - combinations
1.9
6.9
114
702
J01CF05
ATC
flucloxacillin; systemic
2.9
6.9
33
121
JN3BD
NOMESCO Finland
Extensive abdominal CT
2.4
6.9
48
213
A02BC03
ATC
lansoprazole; oral
1.8
6.9
131
843
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
1.8
6.8
153
1032
K21.0
ICD-10 Finland
Gastro-oesophageal reflux disease with oesophagitis
2.4
6.8
48
214
L98.1
ICD-10 Finland
Factitial dermatitis
40.7
6.8
8
*
190
Kela drug reimbursment
Lanthanum carbonate, sevelamer and sucroferric oxyhydroxide
17.0
6.8
10
6
J01FA15
ATC
telithromycin; oral
2.4
6.7
46
202
R02
ICPC
Shortness of breath/dyspnoea
2.2
6.7
61
303
B05DB
ATC
Hypertonic solutions
22.9
6.7
9
*
J01FA10
ATC
azithromycin; systemic
1.7
6.6
236
1803
Z01.0
ICD-10 Finland
Examination of eyes and vision
2.0
6.6
82
459
L50.8
ICD-10 Finland
Other urticaria
7.0
6.6
15
22
TPX10
NOMESCO Finland
Implantation of vascular injection port
3.8
6.6
20
55
B35.3
ICD-10 Finland
Tinea pedis
3.6
6.5
21
60
L15
ICPC
Knee symptom/complaint
1.8
6.5
108
664
I83.1
ICD-10 Finland
Varicose veins of lower extremities with inflammation
5.9
6.5
17
30
C08CA01
ATC
amlodipine; oral
1.7
6.5
163
1131
R4110
NOMESCO Finland
Physiotherapy
1.8
6.5
121
771
M03BX02
ATC
tizanidine; oral
1.7
6.5
245
1899
R01AD58
ATC
fluticasone, combinations; nasal
1.9
6.5
95
562
R53
ICD-10 Finland
Malaise and fatigue
1.8
6.5
109
674
J01DC02
ATC
cefuroxime; systemic
3.0
6.4
28
97
R03BA05
ATC
fluticasone; inhalant
2.0
6.4
82
462
J01FA09
ATC
clarithromycin; systemic
1.8
6.4
132
865
A02BC01
ATC
omeprazole; systemic
1.8
6.4
121
773
K08.80
ICD-10 Finland
Toothache NOS
2.6
6.4
39
162
JHB30
NOMESCO Finland
Rubber band ligature of haemorrhoids or prolapse of mucosa
2.8
6.4
32
120
I95.1
ICD-10 Finland
Orthostatic hypotension
3.3
6.4
24
76
H04.10
ICD-10 Finland
Dry eye syndrome
2.3
6.4
51
240
C08CA02
ATC
felodipine; oral
2.4
6.4
46
207
I84.2
ICD-10 Finland
Internal hemorrhoids without complication
2.6
6.4
36
144
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
2.0
6.4
81
456
A41.0
ICD-10 Finland
Sepsis due to Staphylococcus aureus
5.7
6.4
17
31
A02BA03
ATC
famotidine; systemic
3.5
6.4
22
66
X59
ICD-10 Finland
Exposure to unspecified factor
1.9
6.3
84
480
J45
ICD-10 Finland
Asthma
2.4
6.3
46
208
NH1AA
NOMESCO Finland
Ankle X-ray examination without contrast
2.7
6.3
34
133
Z49.2
ICD-10 Finland
Other dialysis
18.3
6.3
9
5
L04AD01
ATC
ciclosporin; systemic
7.2
6.3
14
20
203
Kela drug reimbursment
Chronic asthma and similar chronic obstructive pulmonary diseases
1.9
6.3
86
497
J04BA02
ATC
dapsone; oral
27.1
6.2
8
*
L17
ICPC
Foot/toe symptom/complaint
1.8
6.2
125
815
A28
ICPC
Limited function/disability NOS
1.9
6.2
82
469
M17.1
ICD-10 Finland
Other primary gonarthrosis
1.9
6.1
96
580
R96
ICPC
Asthma
2.3
6.1
45
205
PBL10
NOMESCO Finland
Construction of arteriovenous fistula from radial artery
10.2
6.1
11
11
J30.4
ICD-10 Finland
Allergic rhinitis, unspecified
4.0
6.0
17
44
J20.9
ICD-10 Finland
Acute bronchitis, unspecified
1.9
6.0
86
503
M01AH02
ATC
rofecoxib; oral
2.1
6.0
60
309
K21.9
ICD-10 Finland
Gastro-oesophageal reflux disease without oesophagitis
2.4
6.0
43
193
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
238
1399
2.63
20.68
6.9
4.2
35.36
35.51
g/l
0.16
228
1314
248
1516
2.56
19.42
10.5
5.2
3.43
2.71
%
3.69
243
1413
250
1534
2.57
19.41
10.0
5.1
57.26
57.42
%
0.08
244
1438
251
1553
2.54
19.00
10.5
5.3
26.50
27.98
%
1.35
244
1453
159
819
2.52
17.57
2.6
2.1
3.09
3.09
mg/l
0.00
138
695
145
729
2.51
16.74
1.4
1.3
1.16
1.49
u/ml
0.32
31
196
66
243
3.04
13.75
15.2
6.4
11.23
9.88
mmol/l
0.83
61
229
101
475
2.49
13.06
3.9
2.1
2.31
2.34
g/l
0.16
95
431
223
1460
2.13
12.87
4.2
2.7
127.98
121.42
ug/l
0.12
212
1331
271
1913
2.18
12.84
12.3
8.6
4.18
4.06
e9/l
0.33
250
1671
120
623
2.30
12.35
4.0
3.9
294.09
395.07
ng/l
0.20
97
505
242
1670
2.07
11.73
11.6
6.2
1.21
1.22
mmol/l
0.31
216
1417
93
445
2.40
11.46
4.3
2.1
20.23
22.74
%
1.07
78
380
167
1018
2.07
11.26
3.5
2.3
53.63
55.15
u/l
0.27
156
940
63
255
2.73
10.95
3.2
3.2
305.55
192.58
ng/l
0.64
58
231
245
1728
2.01
10.83
8.2
6.0
10.70
10.98
umol/l
0.25
236
1641
60
239
2.76
10.75
5.4
3.4
139.30
75.83
ng/l
3.06
53
216
207
1383
1.98
10.63
2.9
2.2
80.01
77.20
nmol/l
0.58
192
1221
222
1521
1.98
10.58
10.0
5.2
1.22
1.22
mmol/l
0.03
202
1382
317
2492
2.13
9.90
6.6
3.8
15.30
11.93
mm/h
3.13
308
2284
132
774
2.03
9.63
1.8
1.5
22.05
20.81
nmol/l
0.42
120
648
75
354
2.36
9.42
2.5
2.5
5.27
9.13
umol/l
2.20
62
302
57
237
2.63
9.37
1.9
1.5
—
—
—
0
0
320
2547
2.09
9.34
12.4
7.1
78.41
78.18
u/l
0.04
311
2377
199
1353
1.90
9.33
2.3
1.9
93.74
96.72
pmol/l
0.39
111
695
220
1554
1.88
9.07
23.1
13.3
1.27
1.23
inr
0.26
71
482
35
113
3.29
9.02
1.2
3.0
—
—
—
0
0
260
1941
1.90
8.98
7.0
4.1
7.10
6.68
mmol/l
2.17
246
1814
57
242
2.57
8.97
1.4
3.1
66.67
66.39
g/l
0.09
52
211
133
801
1.97
8.89
4.3
2.4
8127.68
9787.75
umol/l
0.11
113
699
21
49
4.46
8.50
1.8
1.3
100.44
114.13
u/ml
—
8
8
155
997
1.88
8.42
3.7
3.0
7.09
7.46
mmol/l
0.47
141
828
316
2548
1.98
8.27
4.9
3.9
14.79
14.83
pmol/l
0.09
300
2283
152
987
1.85
7.92
3.3
3.0
4213.05
1367.06
ng/l
1.16
135
842
178
1221
1.80
7.69
4.3
3.0
—
—
—
0
0
95
532
2.02
7.68
2.4
1.8
—
—
—
0
0
63
303
2.27
7.52
2.0
1.8
313.53
384.20
nmol/l
2.26
57
279
152
1001
1.81
7.48
2.8
2.0
205.12
254.42
u/l
0.20
144
945
149
979
1.81
7.37
4.6
3.8
15.53
6.41
mg/mmol
0.84
107
599
28
90
3.26
7.28
1.3
1.3
280.11
326.47
ug/g
0.56
19
54
164
1123
1.76
6.97
3.5
3.5
2.35
2.36
mmol/l
0.64
146
991
357
3085
2.08
6.59
6.0
4.7
1.81
2.32
mu/l
0.70
348
2797
119
753
1.81
6.55
1.9
1.6
1.70
1.15
mg/l
0.33
99
585
19
51
3.86
6.43
1.4
1.2
220.00
253.04
u/ml
0.15
13
27
94
555
1.89
6.43
1.4
1.3
19.23
36.99
iu/ml
2.49
21
193
34
132
2.72
6.38
1.5
2.0
1.51
1.45
g/l
0.14
28
116
6
0
+∞
6.26
6.8
0.0
—
—
—
0
0
149
1038
1.68
5.71
4.3
3.1
328.31
55.60
e6/l
0.51
118
783
22
71
3.22
5.70
2.5
1.8
4608.86
23257.78
e6/l
1.36
14
54
17
47
3.73
5.54
1.5
1.3
—
—
—
0
0
18
53
3.50
5.36
1.4
1.2
—
—
—
0
0
101
645
1.75
5.27
2.0
1.7
1110.18
1221.31
nmol/l
0.58
82
470
256
2067
1.62
5.26
3.1
3.0
—
—
—
0
0
66
374
1.91
5.06
1.9
1.9
—
—
—
0
0
115
769
1.68
5.05
2.8
2.2
—
—
—
0
0
66
375
1.90
5.02
2.0
1.8
—
—
—
0
0
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
23
84
2.84
4.86
3.5
2.3
0.32
0.31
u/ml
0.06
13
47
25
96
2.71
4.82
3.4
2.9
—
—
—
0
0
108
719
1.68
4.80
1.9
1.7
87368913.65
9661458.25
pmol/l
0.42
95
590
89
564
1.73
4.73
2.9
2.5
0.83
1.08
e6/l
0.60
48
302
135
955
1.61
4.71
4.1
2.9
0.35
0.58
e6/l
0.95
105
703
371
3346
1.97
4.67
26.6
13.5
22.75
22.80
mg/l
0.01
321
2643
85
538
1.73
4.53
3.0
2.7
2.40
2.35
e6/l
0.02
42
278
16
49
3.36
4.51
1.2
1.3
—
—
—
0
0
123
860
1.61
4.47
1.8
1.6
1.45
1.35
mmol/l
0.62
117
698
27
114
2.46
4.33
2.3
1.7
—
—
—
0
0
24
96
2.59
4.29
1.9
1.5
0.38
0.05
iu/ml
—
5
22
20
73
2.83
4.24
1.2
1.5
—
—
—
0
0
28
122
2.39
4.20
2.8
1.8
—
—
—
0
0
94
625
1.65
4.15
2.7
2.8
2.45
2.46
mmol/l
0.04
79
554
8
10
8.13
4.07
1.8
1.3
8.16
8.19
ug/l
—
8
10
376
3439
1.93
4.04
29.5
15.6
3.98
3.97
mmol/l
0.45
371
3346
81
523
1.68
3.99
1.3
1.3
3.57
11.69
u/ml
1.97
30
206
18
65
2.85
3.90
1.6
1.2
—
—
—
0
0
18
65
2.85
3.90
1.6
1.2
—
—
—
0
0
22
89
2.55
3.86
1.6
2.4
9.60
11.14
mg/l
0.38
22
80
24
104
2.39
3.67
1.7
1.5
—
—
—
0
0
33
165
2.09
3.61
8.1
7.4
24.87
24.75
mmol/l
0.06
33
160
12
31
3.95
3.51
1.2
1.2
—
—
—
0
0
52
307
1.79
3.51
3.3
2.0
34.77
29.29
u/l
0.27
47
255
13
38
3.50
3.34
1.7
1.5
—
—
—
0
0
6
7
8.67
3.27
1.8
1.0
—
—
—
0
0
42
238
1.85
3.24
2.9
3.0
73.18
63.41
ml/min/173m2
0.86
22
94
39
216
1.89
3.22
1.2
1.2
182.00
166.01
iu/ml
0.08
15
86
16
61
2.69
3.17
1.8
1.5
—
—
—
0
0
13
40
3.32
3.16
2.1
1.3
—
—
—
0
0
14
50
2.86
3.11
1.6
1.6
—
—
—
0
0
57
358
1.69
3.11
6.1
3.2
—
—
—
0
0
22
100
2.27
3.05
1.5
1.6
—
—
—
0
0
7
12
5.91
3.03
2.1
1.7
—
—
—
0
0
7
12
5.91
3.03
2.1
1.7
—
—
—
0
0
7
12
5.91
3.03
4.6
6.8
—
—
—
0
0
7
12
5.91
3.03
2.1
1.7
—
—
—
0
0
19
81
2.41
3.03
2.4
1.4
—
—
—
0
0
17
69
2.53
3.00
3.1
2.2
120.09
129.04
g/l
0.77
11
54
17
69
2.53
3.00
4.7
2.3
15.11
15.81
%
—
10
35
15
57
2.69
2.99
2.2
1.5
—
—
—
0
0
5
5
10.10
2.98
1.0
1.2
—
—
—
0
0
21
95
2.27
2.95
2.0
1.2
—
—
—
0
0
190
1556
1.41
2.94
3.0
2.4
—
—
—
0
0
15
58
2.65
2.90
4.9
2.8
3.78
4.36
e9/l
0.57
15
58
17
72
2.42
2.76
1.4
1.1
—
—
—
0
0
47
292
1.69
2.68
8.6
3.1
5.75
5.76
kpa
0.04
47
283
15
61
2.51
2.65
5.6
2.9
56.53
57.67
%
0.13
15
61
56
366
1.61
2.63
7.0
6.2
1.13
1.34
mmol/l
0.15
47
294
250
2170
1.38
2.61
5.0
2.9
47.55
45.90
u/l
0.16
238
2031
20
95
2.16
2.53
2.1
1.4
1.11
1.16
g/l
0.32
20
90
20
95
2.16
2.53
1.5
1.2
—
—
—
0
0
196
1643
1.36
2.52
4.9
3.6
0.00
0.00
estimate
0.50
50
347
336
3078
1.47
2.50
7.6
5.6
41.04
39.90
mmol/mol
1.09
321
2870
196
1645
1.36
2.49
6.7
4.9
0.00
0.00
estimate
0.50
47
320
79
570
1.48
2.39
1.5
1.5
—
—
—
0
0
12
46
2.66
2.38
1.6
1.6
—
—
—
0
0
17
78
2.23
2.34
1.6
1.3
—
—
—
0
0
26
142
1.89
2.29
6.0
4.5
1.61
1.57
%
0.09
26
133
158
1297
1.35
2.27
4.8
3.6
61.87
37.96
ng/l
0.59
113
935
349
3238
1.47
2.26
5.9
4.5
5.98
5.93
mmol/l
0.30
326
2940
7
18
3.94
2.26
2.1
1.6
—
—
—
0
0
7
18
3.94
2.26
2.1
1.6
—
—
—
0
0
11
41
2.73
2.22
1.5
1.9
32.09
32.37
pg
0.06
11
41
32
189
1.75
2.21
1.8
1.7
—
—
—
0
0
196
1669
1.33
2.17
4.9
3.6
0.07
0.01
estimate
0.40
43
310
7
19
3.73
2.16
1.3
1.7
746.14
365.93
e6/l
—
7
14
7
19
3.73
2.16
2.4
2.0
—
—
—
0
0
11
42
2.66
2.16
3.0
2.0
89.21
89.97
%
0.20
11
42
53
361
1.54
2.11
2.8
2.0
—
—
—
0
0
17
82
2.12
2.10
1.6
1.7
2.48
8.58
iu/l
1.62
11
22
5
10
5.05
2.07
4.4
1.5
22.60
30.20
umol/l
—
5
10
7
20
3.54
2.06
1.4
1.3
—
—
—
0
0
7
20
3.54
2.06
1.4
1.3
—
—
—
0
0
6
15
4.04
2.04
1.7
1.4
—
—
—
0
0
6
15
4.04
2.04
1.7
1.4
—
—
—
0
0
11
44
2.54
2.02
1.1
1.2
0.44
2.25
u/ml
—
6
23
33
203
1.68
1.99
1.8
1.3
—
—
—
0
0
131
1065
1.34
1.96
5.6
3.0
28.69
31.71
u/l
1.10
126
1015
48
327
1.53
1.92
2.7
1.9
—
—
—
0
0
17
86
2.02
1.87
2.9
1.6
—
—
—
0
0
388
3710
1.64
1.86
37.2
19.9
256.22
248.40
e9/l
1.41
383
3625
388
3711
1.63
1.85
37.7
19.8
38.90
39.96
%
2.15
353
3483
6
17
3.56
1.84
1.5
1.2
—
—
—
0
0
6
17
3.56
1.84
1.7
1.5
—
—
—
0
0
6
17
3.56
1.84
1.5
1.2
—
—
—
0
0
16
80
2.04
1.82
2.2
2.5
49.15
89.81
ug/min
—
10
47
43
290
1.54
1.81
9.4
3.8
1.21
1.23
mmol/l
1.78
37
252
388
3714
1.62
1.80
37.1
19.9
4.36
4.47
e12/l
3.78
381
3615
8
29
2.79
1.80
1.5
1.1
—
—
—
0
0
8
29
2.79
1.80
2.1
2.1
—
—
—
0
0
7
24
2.95
1.73
1.0
1.0
—
—
—
0
0
24
141
1.74
1.72
4.2
1.7
—
—
—
0
0
16
82
1.99
1.72
2.6
1.5
—
—
—
0
0
10
40
2.54
1.67
1.5
1.6
—
—
—
0
0
5
14
3.60
1.62
1.0
1.1
—
—
—
0
0
5
14
3.60
1.62
1.0
1.1
—
—
—
0
0
7
26
2.72
1.58
1.0
1.5
—
—
—
0
0
7
26
2.72
1.58
1.1
1.2
—
—
—
0
0
6
20
3.03
1.58
1.8
1.4
0.77
1.15
g/l
—
6
20
7
27
2.62
1.52
1.7
1.2
—
—
—
0
0
6
21
2.88
1.51
1.3
1.2
—
—
—
0
0
17
291
0.57
1.51
1.4
1.6
—
—
—
0
0
10
45
2.25
1.47
1.9
1.4
—
—
—
0
0
10
45
2.25
1.47
1.9
1.3
—
—
—
0
0
10
45
2.25
1.47
1.9
1.4
—
—
—
0
0
10
45
2.25
1.47
1.9
1.4
—
—
—
0
0
11
52
2.15
1.45
1.4
1.2
11.83
23.40
u/l
0.58
11
42
6
22
2.75
1.44
2.0
1.3
82.17
78.05
umol/l
—
6
22
353
3347
1.35
1.43
5.9
4.8
2.65
2.76
mmol/l
1.30
331
3087
16
88
1.85
1.43
1.9
1.5
—
—
—
0
0
10
46
2.20
1.41
1.9
1.3
—
—
—
0
0
10
46
2.20
1.41
1.9
1.3
—
—
—
0
0
372
3559
1.41
1.40
18.1
9.9
24.92
25.36
u/l
0.24
364
3431
7
29
2.44
1.40
2.6
1.6
—
—
—
0
0
7
29
2.44
1.40
2.6
1.6
—
—
—
0
0
7
29
2.44
1.40
2.6
1.6
—
—
—
0
0
12
60
2.03
1.39
1.9
1.5
—
—
—
0
0
12
60
2.03
1.39
1.9
1.5
—
—
—
0
0
69
537
1.34
1.38
1.4
1.4
—
—
—
0
0
36
250
1.48
1.36
6.9
2.5
5.26
4.45
kpa
1.24
36
240
5
17
2.96
1.36
1.0
1.1
9.00
46.36
u/l
—
5
17
5
17
2.96
1.36
1.0
1.1
99.60
113.09
u/l
—
5
17
14
75
1.90
1.36
1.6
1.4
—
—
—
0
0
334
3152
1.30
1.33
24.0
12.8
76.19
80.34
ml/min/173m2
2.03
290
2605
8
34
2.38
1.30
2.9
1.6
—
—
—
0
0
11
55
2.03
1.28
1.0
1.3
0.45
0.60
nmol/l
1.60
11
50
6
25
2.42
1.25
1.7
2.8
—
—
—
0
0
52
395
1.36
1.22
4.9
4.6
32.53
32.22
%
0.07
40
264
41
300
1.41
1.20
9.4
6.7
121.68
121.81
g/l
0.02
41
293
6
26
2.33
1.19
1.0
1.1
—
—
—
0
0
6
26
2.33
1.19
1.0
1.1
—
—
—
0
0
8
38
2.13
1.19
2.9
1.5
—
—
—
0
0
8
40
2.02
1.12
1.5
1.4
—
—
—
0
0
343
3269
1.27
1.11
5.6
4.3
4.56
4.67
mmol/l
1.19
323
3035
29
202
1.47
1.11
6.6
3.0
122.55
128.73
g/l
0.66
29
197
8
41
1.97
1.09
1.3
1.1
—
—
—
0
0
341
3252
1.26
1.07
5.4
4.3
1.45
1.50
mmol/l
1.13
321
3006
331
3147
1.25
1.06
4.9
3.9
1.32
1.27
mmol/l
0.68
308
2893
6
27
2.24
0.94
1.0
1.1
—
—
—
0
0
6
27
2.24
0.94
1.0
1.1
—
—
—
0
0
6
27
2.24
0.94
1.0
1.1
—
—
—
0
0
17
110
1.57
0.92
1.1
1.1
—
—
—
0
0
6
28
2.16
0.92
1.3
1.3
—
—
—
0
0
17
111
1.55
0.89
1.1
1.1
—
—
—
0
0
8
43
1.88
0.87
1.0
1.1
—
—
—
0
0
26
189
1.40
0.83
4.2
1.8
—
—
—
0
0
6
33
1.83
0.79
1.0
1.0
—
—
—
0
0
6
34
1.78
0.76
4.0
3.8
—
—
—
0
0
25
184
1.38
0.76
1.4
1.3
—
—
—
0
0
5
25
2.01
0.73
1.8
1.6
—
—
—
0
0
5
26
1.93
0.71
1.2
1.1
—
—
—
0
0
5
26
1.93
0.71
1.2
1.1
—
—
—
0
0
44
361
1.24
0.64
3.2
4.3
8.53
46.94
ug/l
1.02
35
306
8
49
1.64
0.62
1.0
1.1
—
—
—
0
0
8
50
1.61
0.61
1.4
1.4
—
—
—
0
0
6
37
1.63
0.55
3.2
2.1
—
—
—
0
0
96
874
1.13
0.45
4.4
4.9
2.80
3.17
ug/l
0.13
85
770
22
175
1.27
0.44
1.0
1.0
—
—
—
0
0
11
78
1.42
0.43
1.5
1.3
—
—
—
0
0
0
16
0.00
0.41
0.0
1.4
—
—
—
0
0
0
16
0.00
0.41
0.0
1.1
—
1.06
—
0
5
8
61
1.32
0.39
1.4
1.7
—
—
—
0
0
10
136
0.73
0.38
1.1
1.5
—
—
—
0
0
6
42
1.43
0.35
1.3
1.5
—
—
—
0
0
6
42
1.43
0.35
1.3
1.5
—
—
—
0
0
13
103
1.27
0.28
1.5
1.4
—
—
—
0
0
136
1293
1.08
0.27
5.2
3.7
—
—
—
0
0
11
86
1.29
0.26
1.5
1.3
—
—
—
0
0
42
380
1.12
0.24
7.9
6.7
—
—
—
0
0
10
79
1.27
0.22
1.3
1.1
—
—
—
0
0
0
11
0.00
0.21
0.0
1.0
—
101.60
—
0
5
0
11
0.00
0.21
0.0
1.3
—
—
—
0
0
(3011547) Coagulation factor VII activity actual/normal in Platelet poor plasma by Coagulation assay
0
11
0.00
0.21
0.0
1.0
—
133.09
—
0
11
0
11
0.00
0.21
0.0
1.3
—
—
—
0
0
0
11
0.00
0.21
0.0
1.0
—
113.60
—
0
5
0
11
0.00
0.21
0.0
1.3
—
—
—
0
0
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
1.2
—
—
—
0
0
0
10
0.00
0.21
0.0
1.3
—
—
—
0
0
5
43
1.16
0.21
1.0
1.1
—
—
—
0
0
0
14
0.00
0.20
0.0
1.5
—
—
—
0
0
6
50
1.20
0.20
1.0
1.6
—
—
—
0
0
7
59
1.19
0.18
2.0
1.8
—
—
—
0
0
73
692
1.07
0.16
3.8
4.2
21.09
21.44
%
0.06
28
316
47
499
0.93
0.13
2.9
3.0
0.50
0.85
ug/l
3.90
33
315
11
95
1.16
0.11
1.5
1.5
—
—
—
0
0
7
81
0.86
0.07
2.4
1.7
—
—
—
0
0
9
105
0.85
0.06
2.0
1.9
—
—
—
0
0
75
733
1.03
0.05
4.6
3.8
1.01
1.02
kg/l
0.29
12
99
91
914
0.99
0.00
5.9
3.8
0.00
0.01
estimate
0.80
45
316
0
7
0.00
0.00
0.0
1.4
—
—
—
0
0
0
7
0.00
0.00
0.0
1.3
—
—
—
0
0
(3002348) Coagulation factor XII activity actual/normal in Platelet poor plasma by Coagulation assay
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
2.2
—
1.32
—
0
6
0
8
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
5
56
0.89
-0.00
2.0
1.6
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.8
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.5
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint L12_PRURIGONAS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_PRURIGONAS | 1.386 [1.18, 1.63] | < 0.001 |
| Birth year | 0.995 [0.99, 1.0] | 0.214 |
During the follow-up period (1.1.1998 — 31.12.2019), 337 out of 1532 females with L12_PRURIGONAS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_PRURIGONAS | 1.635 [1.33, 2.01] | < 0.001 |
| Birth year | 0.984 [0.97, 0.99] | 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 342 out of 1002 males with L12_PRURIGONAS died.
Mortality risk
Mortality risk for people of age
years, who have L12_PRURIGONAS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.094% | 0.339% |
| 5 | 0.64% | 1.753% |
| 10 | 1.935% | 4.381% |
| 15 | 3.65% | 8.135% |
| 20 | 6.816% | 13.54% |
Relationships between endpoints
↥Index endpoint: L12_PRURIGONAS – Other prurigo
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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