intestinal perforation: Opening or penetration through the wall of the INTESTINES.
Other congenital malformations of intestine
DOID EFO Endpoint Browser PheWeb
Q17_OTHER_CONGEN_MALFO_INTESTINE
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519972 |
1. Apply sex-specific ruleNone |
519972 |
2. Check conditionsNone |
519972 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
322 |
4. Check minimum number of eventsNone |
322 |
5. Include endpointsNone |
322 |
6. Filter based on genotype QC (FinnGen only) |
309 |
Control definitions (FinnGen only)
- Control exclude
- Q17_OTHER_CONGEN_MALFO_DIGES_SYSTEM1
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF4
- Parent code in ICD-10
- Q3[8-9]|Q4[0-5]
- Name in latin
- Aliae malformationes congenitae intestini
Similar endpoints
↥List of similar endpoints to
Other congenital malformations of intestine
based on the number of shared cases.
Similar with more cases:
- Other congenital malformations of the digestive system
- Other congenital malformations of the digestive system
- Congenital malformations, deformations and chromosomal abnormalities
- Congenital malformations, deformations and chromosomal abnormalities
- Any event in hilmo or specialist outpatient
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 3727 | 1773 | 1940 |
| Only index persons | 3073 | 1448 | 1625 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.05 | 0.05 | 0.05 |
| Only index persons | 0.06 | 0.05 | 0.06 |
| Median age at first event (years) | |||
| Whole population | 16.48 | 14.08 | 18.30 |
| Only index persons | 23.09 | 22.17 | 23.91 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 309 | 165 | 144 |
| Unadjusted period prevalence (%) | 0.06 | 0.06 | 0.07 |
| Median age at first event (years) | 46.46 | 45.26 | 47.84 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 322
- Matched controls
- 3220
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
Q43.0
ICD-10 Finland
Meckel diverticulum
+∞
194.0
166
*
JFB00
NOMESCO Finland
Partial resection of small intestine
41.2
83.8
52
15
Q43.8
ICD-10 Finland
Other specified congenital malformations of intestine
628.4
55.3
53
*
JN3AA
NOMESCO Finland
Abdominal X-ray examination without contrast
12.8
51.8
54
50
JFA73
NOMESCO Finland
Excision of lesion of small intestine
+∞
45.9
43
*
Q43.1
ICD-10 Finland
Hirschsprung disease
+∞
44.8
42
*
JEA00
NOMESCO Finland
Appendectomy
8.5
43.6
63
90
K56.6
ICD-10 Finland
Other and unspecified intestinal obstruction
14.3
38.1
36
28
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
4.1
34.6
187
814
JAH00
NOMESCO Finland
Laparotomy
11.8
32.8
35
33
UJF32
NOMESCO Finland
Coloscopy
3.8
28.1
122
445
JN3BD
NOMESCO Finland
Extensive abdominal CT
5.4
28.0
63
139
P01AB01
ATC
metronidazole; oral, rectal
3.3
25.1
166
779
JAH01
NOMESCO Finland
Laparoscopy
7.8
24.7
36
51
WX302
NOMESCO Finland
Thoracal epidural anesthesy
7.2
24.0
38
59
ZXD05
NOMESCO Finland
Urgent procedure
3.3
23.5
142
627
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
3.4
23.4
124
506
K57.3
ICD-10 Finland
Diverticular disease of large intestine without perforation or abscess
4.0
23.3
80
245
JF1AB
NOMESCO Finland
Passage examination of small bowell with X-ray
27.4
22.2
30
12
Q43.5
ICD-10 Finland
Ectopic anus
+∞
22.1
21
*
WX408
NOMESCO Finland
General anesthesy, balanced
3.0
19.9
127
569
TJF80
NOMESCO Finland
Ostomy education
33.7
19.6
25
8
ZXE10
NOMESCO Finland
More than one and less than three hours
2.9
19.4
153
766
Q43.30
ICD-10 Finland
Template rotation of colon
+∞
18.9
18
*
JN3AD
NOMESCO Finland
Abdominal CT examination
4.1
18.0
56
158
TPH07
NOMESCO Finland
Cathetrisation of artery
3.6
15.8
58
183
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
3.2
15.5
72
264
WX404
NOMESCO Finland
Intravenous generell anesthesy
2.8
15.2
100
445
K56.5
ICD-10 Finland
Intestinal adhesions [bands] with obstruction
16.1
15.1
24
16
ZXE20
NOMESCO Finland
More than three and less than five hours
3.2
14.4
67
245
A06AC01
ATC
ispaghula (psylla seeds); oral
2.8
14.4
97
436
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
4.2
13.8
39
102
K57.2
ICD-10 Finland
Diverticular disease of large intestine with perforation and abscess
12.9
13.3
23
19
ZXD10
NOMESCO Finland
Scheduled procedure
2.4
12.7
144
819
Q43.9
ICD-10 Finland
Congenital malformation of intestine, unspecified
+∞
12.6
12
*
R10.3
ICD-10 Finland
Pain localized to other parts of lower abdomen
2.6
12.6
92
428
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
2.6
12.1
89
414
K35.9
ICD-10 Finland
Acute appendicitis, unspecified
3.6
11.8
41
124
Q43.2
ICD-10 Finland
Other congenital functional disorders of colon
+∞
11.5
11
*
Q42.2
ICD-10 Finland
Congenital absence, atresia and stenosis of anus with fistula
+∞
11.5
11
*
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
2.8
11.4
68
284
TJD20
NOMESCO Finland
Change of gastrostomy tube
26.1
11.2
15
6
TPH04
NOMESCO Finland
Cathetrisation of vein
2.5
10.9
83
391
UJF45
NOMESCO Finland
Flexible sigmoidoscopy with biopsy
3.8
10.5
33
93
Z3226
NOMESCO Finland
Physiotherapist
2.5
10.5
82
390
Q42.0
ICD-10 Finland
Congenital absence, atresia and stenosis of rectum with fistula
+∞
10.5
10
*
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.2
10.4
153
949
WX882
NOMESCO Finland
High dependency care
4.2
10.4
29
75
K56.2
ICD-10 Finland
Volvulus
19.6
10.4
15
8
UJD02
NOMESCO Finland
Gastroscopy
4.3
10.2
27
67
Z2446
NOMESCO Finland
Social worker
3.1
10.1
46
165
TJD00
NOMESCO Finland
Insertion of nasogastric or naso-gastroduodenal tube
12.7
10.0
17
14
K56.7
ICD-10 Finland
Ileus, unspecified
12.7
10.0
17
14
JDB00
NOMESCO Finland
Gastrostomy
56.7
9.7
11
*
WX002
NOMESCO Finland
Sedation and analgesia
2.5
9.6
72
335
J01MA02
ATC
ciprofloxacin; systemic
2.1
9.4
126
746
TPH90
NOMESCO Finland
Removal of fixed intravenous catheter
9.1
9.4
19
22
Q42.3
ICD-10 Finland
Congenital absence, atresia and stenosis of anus without fistula
+∞
9.4
9
*
7513A
ICD-9 Finland
Other congenital anomalies of digestive system, Hirschsprung's disease and other congenital functional disorders of colon[MORBUS HIRSCHPRUNG]
+∞
9.4
9
*
T81.4
ICD-10 Finland
Infection following a procedure, not elsewhere classified
3.0
9.4
44
160
Z2221
NOMESCO Finland
Medical doctor
2.2
9.3
106
589
A03FA02
ATC
cisapride; oral, rectal
3.7
9.2
30
87
K59.0
ICD-10 Finland
Constipation
3.5
9.0
32
98
N02AX02
ATC
tramadol; systemic, rectal
2.1
9.0
133
815
ZXE30
NOMESCO Finland
More than five and less than seven hours
4.0
9.0
26
69
K65.0
ICD-10 Finland
Acute peritonitis
24.8
9.0
12
5
WX892
NOMESCO Finland
Monitored bed care
3.2
8.5
35
118
JGB20
NOMESCO Finland
Partial rectosigmoidectomy and abdominoperineal pull-through anastomosis
92.4
8.5
9
*
ZXE00
NOMESCO Finland
One hour or less
2.0
8.4
142
909
JFA74
NOMESCO Finland
Laparoscopic excision of lesion of small intestine
+∞
8.4
8
*
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
2.4
8.3
63
294
UJF30
NOMESCO Finland
Ileoscopy through colon
3.0
8.2
38
137
A06AD11
ATC
lactulose; oral
2.6
8.2
50
210
K92.1
ICD-10 Finland
Melaena
3.7
8.2
26
74
JFG40
NOMESCO Finland
Revision of enterostomy or colostomy without laparotomy
34.3
8.1
10
*
JF2AB
NOMESCO Finland
Colongraphy with X-ray
34.3
8.1
10
*
WX730
NOMESCO Finland
Conventional respirator
22.7
8.1
11
5
RD210, ,
NOMESCO Finland
4.3
7.9
21
52
WX402
NOMESCO Finland
General anaesthesia
2.2
7.9
82
436
R10.1
ICD-10 Finland
Pain localized to upper abdomen
2.3
7.8
67
329
601
Kela drug reimbursment
Severe malabsorption of nutrients, mainly fats
15.5
7.8
12
8
KH1AE
NOMESCO Finland
Urinary tract ultrasound examination
3.2
7.5
31
105
368
Kela drug reimbursment
Combination product containing docusate sodium and sorbitol
+∞
7.3
7
*
A06AG10
ATC
docusate sodium, incl. combinations; rectal
+∞
7.3
7
*
Q87.26
ICD-10 Finland
VATER association
+∞
7.3
7
*
6504
FHL
Reconstruction
+∞
7.3
7
*
504
Kela drug reimbursment
Conditions requiring daily forced enteral nutrition
6.8
7.2
17
26
JHW96
NOMESCO Finland
Other operation on anus or perianal tissue
30.8
7.2
9
*
JAP00
NOMESCO Finland
Freeing of adhesions in the peritoneal cavity
20.6
7.2
10
5
JWA00
NOMESCO Finland
Repair of wound dehiscence in gastroenterological surgery
20.6
7.2
10
5
K57.9
ICD-10 Finland
Diverticular disease of intestine, part unspecified, without perforation or abscess
7.3
7.1
16
23
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
2.6
7.0
42
174
QBB10
NOMESCO Finland
Major dressing of wound of skin of trunk
4.1
7.0
19
48
JFG10
NOMESCO Finland
Closure of loop colostomy without resection
17.1
6.8
10
6
Z3231
NOMESCO Finland
Registered nurse
1.9
6.7
104
637
UJG02
NOMESCO Finland
Proctoscopy
8.1
6.7
14
18
D06
ICPC
Abdominal pain localized other
2.7
6.6
37
148
K59.09
ICD-10 Finland
Constipation, unspecified
3.0
6.6
30
107
D01
ICPC
Abdominal pain/cramps general
2.3
6.6
53
252
K57.1
ICD-10 Finland
Diverticular disease of small intestine without perforation or abscess
10.3
6.6
12
12
A02BC02
ATC
pantoprazole; systemic
1.8
6.5
192
1433
JFH10
NOMESCO Finland
Total colectomy and ileostomy
71.2
6.4
7
*
JFG00
NOMESCO Finland
Closure of loop enterostomy without resection
18.5
6.3
9
5
GD1RA
NOMESCO Finland
Dynamic X-ray examination of respiratory organs with convetional X-ray picture
+∞
6.3
6
*
JEW96
NOMESCO Finland
Other operation on appendix
+∞
6.3
6
*
R2110
NOMESCO Finland
Giving the first information
3.3
6.1
23
73
JHD00
NOMESCO Finland
Anal dilatation
12.8
6.1
10
8
RS220, ,
NOMESCO Finland
6.9
6.1
14
21
JFB30
NOMESCO Finland
Right hemicolectomy
10.3
6.1
11
11
T81.3
ICD-10 Finland
Disruption of operation wound, not elsewhere classified
6.2
6.1
15
25
D50.9
ICD-10 Finland
Iron deficiency anaemia, unspecified
3.1
6.0
26
90
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
204
1250
2.72
16.62
9.1
6.3
12.20
12.98
umol/l
0.19
191
1188
175
1010
2.60
15.88
9.3
5.2
35.48
36.22
g/l
0.95
165
952
251
1881
2.52
10.88
11.8
6.8
89.15
84.16
u/l
0.72
241
1759
27
65
4.44
10.58
2.0
1.2
—
—
—
0
0
43
154
3.07
9.45
2.2
1.6
—
—
—
0
0
143
903
2.05
8.90
5.6
3.3
—
—
—
0
0
104
586
2.14
8.75
4.2
2.3
—
—
—
0
0
121
732
2.05
8.36
4.9
3.2
0.28
0.32
e6/l
0.14
102
548
175
1224
1.94
7.81
14.6
7.6
1.21
1.22
mmol/l
0.40
153
1068
151
1006
1.94
7.79
4.1
2.5
72.14
74.01
nmol/l
0.39
137
911
64
309
2.34
7.76
16.0
6.0
1.78
1.42
mmol/l
0.44
54
239
51
222
2.54
7.74
16.8
9.5
1.31
1.36
mmol/l
0.12
51
214
64
312
2.31
7.58
16.2
5.9
5.84
5.75
kpa
0.39
64
302
81
436
2.15
7.53
3.8
3.1
3.97
2.18
e6/l
0.47
47
242
123
774
1.95
7.43
3.3
3.3
2.37
2.36
mmol/l
0.37
116
689
210
1578
1.95
7.39
13.1
9.3
4.41
4.02
e9/l
1.24
186
1367
163
1132
1.89
7.26
17.7
7.4
1.21
1.22
mmol/l
0.51
150
1050
82
451
2.10
7.18
3.7
3.0
1.90
0.73
e6/l
0.81
49
254
72
384
2.13
6.80
9.7
4.7
0.82
0.82
mmol/l
0.03
67
362
69
367
2.12
6.55
2.0
1.9
—
—
—
0
0
129
858
1.84
6.37
6.8
3.1
32.93
32.08
u/l
0.12
120
815
159
1146
1.77
5.86
4.1
2.6
—
—
—
0
0
21
65
3.39
5.83
1.6
1.5
—
—
—
0
0
13
19
7.08
5.79
10.5
1.5
24.31
31.05
umol/l
1.23
13
19
96
600
1.85
5.67
4.7
2.4
2.88
2.88
mg/l
0.00
91
512
49
244
2.19
5.46
3.6
2.4
31.64
29.24
u/l
0.27
44
203
55
290
2.08
5.29
20.4
7.6
105.33
104.32
mmol/l
0.79
55
290
54
283
2.09
5.28
16.8
5.7
5.42
4.71
kpa
1.42
54
273
192
1488
1.72
5.25
10.6
5.3
6.34
6.58
mmol/l
1.13
182
1384
48
243
2.15
5.13
13.2
5.4
1.89
1.27
mmol/l
0.98
37
182
294
2611
2.45
5.12
28.5
14.3
139.27
139.65
mmol/l
1.85
285
2540
294
2617
2.42
4.98
28.7
14.3
3.97
3.97
mmol/l
0.11
286
2538
123
856
1.71
4.92
2.6
1.9
97.57
94.69
pmol/l
0.28
70
439
24
91
2.77
4.77
1.4
1.2
—
—
—
0
0
74
451
1.83
4.65
4.8
3.7
450.01
381.37
ng/l
0.09
51
333
11
20
5.65
4.32
8.3
1.4
26.20
19.40
umol/l
0.29
11
20
65
390
1.84
4.27
3.1
3.0
2.44
2.44
mmol/l
0.09
58
342
293
2640
2.22
4.21
24.3
12.5
29.64
22.67
mg/l
2.64
257
2002
160
1230
1.60
4.14
5.3
4.6
0.00
0.00
estimate
-0.00
33
218
149
1130
1.59
4.06
4.3
2.7
100.16
105.17
ug/l
0.12
138
1042
137
1022
1.59
3.98
13.4
11.3
1.23
1.22
inr
0.04
43
316
42
223
2.02
3.96
4.3
4.4
2.84
10.42
ug/l
2.29
31
179
159
1233
1.57
3.88
4.2
3.2
0.00
0.00
estimate
0.50
33
230
47
265
1.91
3.74
2.0
1.8
—
—
—
0
0
159
1242
1.55
3.70
4.2
3.2
0.00
0.00
estimate
-0.00
34
207
15
52
2.98
3.51
32.5
8.8
78.70
64.84
%
1.61
15
52
207
1733
1.54
3.40
6.9
3.1
45.70
43.84
u/l
0.10
194
1645
221
1878
1.56
3.38
5.1
3.9
12.38
10.54
mm/h
1.02
212
1738
26
122
2.23
3.36
2.1
1.7
—
—
—
0
0
43
244
1.88
3.36
9.0
10.9
-0.17
1.03
mmol/l
0.95
37
204
79
542
1.61
3.15
3.0
2.3
0.95
1.13
mg/l
0.38
64
414
44
258
1.82
3.11
17.3
7.4
6.46
7.80
mmol/l
1.17
44
253
45
266
1.80
3.09
2.0
1.8
—
—
—
0
0
18
77
2.42
2.87
2.1
2.1
—
—
—
0
0
25
124
2.10
2.85
20.6
5.7
0.74
0.66
%
0.44
25
124
16
65
2.54
2.83
2.1
1.7
—
—
—
0
0
9
24
3.83
2.69
6.0
3.4
96.00
98.13
%
—
9
24
264
2383
1.60
2.68
28.1
15.3
15.19
14.40
%
1.25
259
2353
225
1964
1.48
2.67
3.3
3.4
—
—
—
0
0
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
15
63
2.45
2.50
5.3
6.4
0.28
0.33
u/ml
—
9
38
59
401
1.58
2.43
4.2
3.0
29.79
29.80
s
0.01
59
394
16
71
2.32
2.38
1.7
1.7
—
—
—
0
0
16
72
2.29
2.31
2.2
1.9
—
—
—
0
0
221
1951
1.42
2.25
4.6
3.7
14.85
14.62
pmol/l
0.67
208
1766
60
418
1.54
2.22
1.7
1.7
412.02
447.35
pmol/l
0.66
52
349
292
2734
1.73
2.18
16.8
9.5
28.14
27.02
u/l
0.28
284
2632
21
109
1.99
2.16
3.7
2.5
25255.70
4171.42
u/l
—
10
37
83
626
1.44
2.08
5.1
3.4
0.00
0.00
estimate
0.50
32
213
5
10
5.06
2.08
1.2
1.4
—
—
—
0
0
6
15
4.05
2.05
2.3
1.6
0.91
1.07
g/l
—
6
15
53
366
1.54
2.04
2.0
1.7
1234.77
1175.57
nmol/l
0.16
35
266
15
70
2.20
2.01
1.5
1.7
—
—
—
0
0
18
91
2.04
1.99
1.6
1.2
—
—
—
0
0
15
71
2.17
1.95
2.1
1.6
269.00
195.03
u/ml
—
7
40
6
16
3.80
1.94
2.8
2.0
—
—
—
0
0
18
92
2.01
1.94
1.6
1.2
—
—
—
0
0
13
59
2.25
1.86
1.2
1.2
—
—
—
0
0
13
59
2.25
1.86
1.2
1.2
—
—
—
0
0
15
73
2.11
1.83
1.4
1.3
342.00
297.84
ug/g
—
10
42
116
945
1.36
1.82
4.2
3.2
—
—
—
0
0
8
29
2.80
1.80
1.6
1.2
—
—
—
0
0
23
133
1.79
1.75
1.4
1.3
—
—
—
0
0
247
2262
1.39
1.75
20.7
11.3
88.28
86.44
ml/min/173m2
0.59
215
1811
5
14
3.61
1.62
4.0
2.1
—
—
—
0
0
15
77
1.99
1.62
2.1
1.6
—
—
—
0
0
10
44
2.31
1.57
2.7
3.6
4.66
4.40
e9/l
—
10
44
10
44
2.31
1.57
2.7
3.7
60.90
57.18
%
—
10
44
5
15
3.37
1.53
1.4
1.3
—
—
—
0
0
7
27
2.63
1.52
1.1
1.6
—
—
—
0
0
6
22
2.76
1.44
1.5
1.5
—
—
—
0
0
10
46
2.21
1.41
1.2
1.2
—
—
—
0
0
9
41
2.23
1.38
1.8
1.6
—
—
—
0
0
9
41
2.23
1.38
1.3
1.5
—
—
—
0
0
9
41
2.23
1.38
1.2
1.7
—
—
—
0
0
9
41
2.23
1.38
1.2
1.7
—
—
—
0
0
6
23
2.64
1.37
1.0
1.1
—
—
—
0
0
13
68
1.95
1.35
1.2
1.5
—
—
—
0
0
0
41
0.00
1.32
0.0
1.4
—
7.45
—
0
32
8
34
2.39
1.30
1.3
1.6
—
—
—
0
0
8
34
2.39
1.30
1.1
1.5
—
—
—
0
0
12
62
1.97
1.29
2.1
2.4
—
—
—
0
0
8
35
2.32
1.27
2.5
1.4
—
—
—
0
0
8
36
2.25
1.25
1.3
1.5
—
—
—
0
0
6
25
2.43
1.25
6.7
2.9
2.17
3.13
nmol/l
—
6
25
6
25
2.43
1.25
8.5
13.0
1225.50
1436.28
nmol/l
—
6
25
16
93
1.76
1.23
1.6
1.6
—
—
—
0
0
306
2959
1.69
1.23
35.1
18.7
40.07
40.37
%
0.41
291
2793
30
207
1.50
1.20
1.0
1.0
—
—
—
0
0
26
174
1.54
1.19
4.2
2.4
70.44
68.29
ml/min/173m2
—
9
79
8
38
2.13
1.19
2.0
3.1
—
—
—
0
0
10
50
2.03
1.17
1.3
1.5
—
—
—
0
0
5
20
2.52
1.15
1.8
1.3
—
—
—
0
0
8
41
1.97
1.09
2.0
2.8
0.22
0.20
e9/l
—
8
32
100
849
1.26
1.09
3.6
3.4
31.66
37.46
ng/l
0.23
64
552
24
163
1.51
1.05
15.2
3.3
1.24
1.22
mmol/l
0.58
18
140
5
22
2.29
1.03
1.0
1.0
—
—
—
0
0
7
34
2.08
1.03
1.1
1.5
—
—
—
0
0
11
61
1.83
0.99
1.4
2.2
—
—
—
0
0
15
92
1.66
0.99
1.0
1.5
301.60
267.42
miu/ml
—
5
47
5
23
2.19
0.98
1.2
1.2
—
—
—
0
0
7
36
1.96
0.97
1.4
1.4
—
—
—
0
0
9
50
1.82
0.97
1.2
1.7
—
—
—
0
0
49
385
1.32
0.97
1.3
1.3
15.98
8.29
u/ml
0.46
18
138
233
2185
1.24
0.95
5.7
5.3
38.47
39.44
mmol/mol
0.91
222
2043
7
37
1.91
0.94
1.0
1.2
—
—
—
0
0
10
55
1.84
0.93
1.7
1.7
—
—
—
0
0
10
55
1.84
0.93
1.7
1.7
—
—
—
0
0
10
56
1.81
0.88
1.5
1.4
—
—
—
0
0
74
622
1.25
0.88
2.9
3.5
1938.49
974.08
ng/l
0.52
60
521
6
114
0.52
0.84
1.2
1.7
—
—
—
0
0
16
106
1.54
0.80
1.4
1.5
—
—
—
0
0
248
2358
1.23
0.79
5.4
4.3
1.75
1.89
mu/l
1.54
236
2155
0
24
0.00
0.79
0.0
2.8
—
—
—
0
0
6
34
1.78
0.76
1.8
1.4
—
—
—
0
0
5
24
2.10
0.75
1.4
1.2
—
—
—
0
0
45
364
1.27
0.74
1.4
1.4
—
—
—
0
0
87
758
1.20
0.73
1.4
1.4
3.55
1.37
u/ml
0.59
26
183
5
25
2.02
0.73
1.0
1.0
—
—
—
0
0
43
347
1.28
0.73
1.8
1.9
1.42
1.46
%
0.17
36
315
239
2274
1.20
0.71
4.1
3.7
1.30
1.27
mmol/l
0.24
227
2105
63
536
1.22
0.68
3.6
4.2
22.27
21.76
%
0.10
29
230
7
43
1.64
0.67
2.1
2.7
620.29
581.84
e6/l
—
7
32
5
29
1.74
0.64
2.0
1.5
—
—
—
0
0
5
29
1.74
0.64
2.0
1.5
—
—
—
0
0
5
30
1.68
0.61
2.6
1.5
—
—
—
0
0
5
30
1.68
0.61
3.8
2.8
26.32
19.07
ug/l
—
5
30
5
30
1.68
0.61
2.6
1.5
—
—
—
0
0
5
30
1.68
0.61
2.6
1.5
—
—
—
0
0
5
30
1.68
0.61
2.0
1.5
—
—
—
0
0
23
175
1.34
0.60
1.7
1.3
—
—
—
0
0
6
35
1.73
0.58
2.2
1.3
0.48
0.48
nmol/l
—
6
30
28
223
1.28
0.54
3.5
3.1
—
—
—
0
0
6
39
1.55
0.53
1.2
1.1
—
—
—
0
0
13
92
1.43
0.51
1.2
1.3
—
—
—
0
0
48
412
1.19
0.49
1.3
1.3
58.55
27.59
iu/ml
0.43
13
130
11
77
1.44
0.46
1.4
1.7
—
—
—
0
0
73
656
1.15
0.43
1.9
1.7
—
—
—
0
0
6
91
0.65
0.43
1.2
1.6
—
—
—
0
0
8
59
1.36
0.41
1.3
2.6
37.49
146.70
mg/l
—
8
47
8
59
1.36
0.41
1.3
2.6
29.26
29.91
mg/l
—
8
47
0
16
0.00
0.41
0.0
1.4
—
—
—
0
0
0
16
0.00
0.41
0.0
1.1
—
—
—
0
0
0
16
0.00
0.41
0.0
1.3
—
—
—
0
0
0
16
0.00
0.41
0.0
1.2
—
—
—
0
0
8
60
1.34
0.40
1.1
1.5
—
—
—
0
0
66
595
1.14
0.38
3.8
3.0
333.05
6065.52
umol/l
2.20
59
518
76
694
1.12
0.36
4.5
4.7
2.06
2.14
ug/l
0.07
68
612
6
42
1.44
0.35
2.0
1.5
—
—
—
0
0
45
398
1.15
0.34
2.6
2.8
0.59
0.82
ug/l
1.43
31
253
6
47
1.28
0.32
1.0
1.1
—
—
—
0
0
7
52
1.35
0.31
1.4
1.2
—
—
—
0
0
247
2409
1.11
0.30
4.9
4.6
2.67
2.76
mmol/l
0.85
235
2239
7
56
1.26
0.29
1.0
1.1
—
—
—
0
0
7
57
1.23
0.29
1.7
1.2
—
—
—
0
0
13
162
0.79
0.29
1.3
1.5
—
—
—
0
0
244
2381
1.10
0.29
4.5
4.1
4.46
4.62
mmol/l
1.70
233
2221
242
2365
1.09
0.26
4.2
4.1
1.36
1.44
mmol/l
2.67
232
2193
9
75
1.21
0.25
2.1
1.3
—
—
—
0
0
70
653
1.09
0.23
3.9
3.9
2.63
10.43
mg/mmol
3.51
44
418
7
92
0.76
0.23
1.4
1.1
—
10.27
—
0
13
5
40
1.25
0.22
1.0
1.1
—
—
—
0
0
5
40
1.25
0.22
1.0
1.1
—
—
—
0
0
0
11
0.00
0.21
0.0
1.0
—
—
—
0
0
0
11
0.00
0.21
0.0
1.0
—
—
—
0
0
0
10
0.00
0.21
0.0
2.1
—
—
—
0
0
0
10
0.00
0.21
0.0
2.1
—
—
—
0
0
0
10
0.00
0.21
0.0
2.1
—
—
—
0
0
70
657
1.08
0.21
2.1
1.7
1.32
1.41
mmol/l
0.39
62
558
0
13
0.00
0.21
0.0
1.1
—
—
—
0
0
7
63
1.11
0.17
1.6
1.4
—
—
—
0
0
6
76
0.79
0.16
1.5
1.6
—
—
—
0
0
5
44
1.14
0.10
2.4
1.7
—
—
—
0
0
44
420
1.06
0.09
1.9
2.3
—
—
—
0
0
5
63
0.79
0.08
3.2
1.9
—
—
—
0
0
7
84
0.83
0.07
1.3
1.5
—
—
—
0
0
7
84
0.83
0.07
1.3
1.5
—
—
—
0
0
7
84
0.83
0.07
1.3
1.5
—
—
—
0
0
9
84
1.07
0.07
1.3
2.0
—
—
—
0
0
20
187
1.07
0.06
1.1
1.2
51.64
158.36
iu/ml
—
8
68
9
104
0.86
0.06
1.3
2.3
48.78
41.49
u/l
—
9
97
233
2315
1.02
0.04
4.5
4.1
5.84
5.88
mmol/l
0.22
217
2122
23
220
1.05
0.03
1.9
1.9
—
—
—
0
0
39
379
1.03
0.03
1.9
2.1
—
—
—
0
0
14
132
1.06
0.02
7.3
2.4
0.11
0.13
e6/l
0.10
14
124
24
234
1.03
0.00
1.6
1.5
—
—
—
0
0
11
111
0.99
0.00
1.5
1.4
—
—
—
0
0
25
253
0.99
0.00
5.8
6.6
—
—
—
0
0
11
106
1.04
0.00
1.2
1.1
—
—
—
0
0
17
174
0.98
0.00
1.8
1.8
—
—
—
0
0
0
6
0.00
-0.00
0.0
2.7
—
25.98
—
0
6
0
9
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.8
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.5
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
6
68
0.88
-0.00
1.8
1.8
—
—
—
0
0
0
5
0.00
-0.00
0.0
4.0
—
30.20
—
0
5
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.4
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint Q17_OTHER_CONGEN_MALFO_INTESTINE and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| Q17_OTHER_CONGEN_MALFO_INTESTINE | 1.262 [1.0, 1.59] | 0.047 |
| Birth year | 0.992 [0.98, 1.0] | 0.057 |
During the follow-up period (1.1.1998 — 31.12.2019), 156 out of 1498 females with Q17_OTHER_CONGEN_MALFO_INTESTINE died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| Q17_OTHER_CONGEN_MALFO_INTESTINE | 1.574 [1.26, 1.97] | < 0.001 |
| Birth year | 0.99 [0.98, 1.0] | 0.035 |
During the follow-up period (1.1.1998 — 31.12.2019), 193 out of 1619 males with Q17_OTHER_CONGEN_MALFO_INTESTINE died.
Mortality risk
Mortality risk for people of age
years, who have Q17_OTHER_CONGEN_MALFO_INTESTINE.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.114% | 0.398% |
| 5 | 0.63% | 2.107% |
| 10 | 1.673% | 5.054% |
| 15 | 3.275% | 9.363% |
| 20 | 5.698% | 15.628% |
Relationships between endpoints
↥Index endpoint: Q17_OTHER_CONGEN_MALFO_INTESTINE – Other congenital malformations of intestine
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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