No definition available.
Brain glioblastoma, excluding all cancers (controls excluding all cancers)
C3_GBM_EXALLC
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditions
|
435 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
435 |
4. Check minimum number of eventsNone |
435 |
5. Include endpoints |
435 |
6. Filter based on genotype QC (FinnGen only) |
435 |
Control definitions (FinnGen only)
- Control exclude
- C3_CANCER, C3_CANCER_WIDE_EXALLC
- Control conditions
- not HLP_C3_GBM
Extra metadata
- First used in FinnGen datafreeze
- DF12
Similar endpoints
↥List of similar endpoints to
Brain glioblastoma, excluding all cancers (controls excluding all cancers)
based on the number of shared cases.
Similar with more cases:
- Brain glioblastoma
- Brain glioblastoma and astrocytoma
- Brain glioblastoma and astrocytoma, excluding all cancers (controls excluding all cancers)
- Malignant neoplasm of brain
- Malignant neoplasm of eye, brain and central nervous system
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
This endpoint is excluded (different definition than used in FinnGen).
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 435 | 177 | 258 |
| Unadjusted period prevalence (%) | 0.09 | 0.06 | 0.11 |
| Median age at first event (years) | 65.80 | 66.18 | 65.54 |
-FinnGen-
Age distribution of first events
-FinnGen-
Year distribution of first events
-FinnGen-
Cumulative Incidence Function
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 411
- Matched controls
- 4109
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
AAB10
NOMESCO Finland
Partial excision of intracranial lesion
1593.3
323.0
313
8
H02AB02
ATC
dexamethasone; systemic
1757.5
323.0
362
17
L01AX03
ATC
temozolomide; systemic
+∞
323.0
273
*
130
Kela drug reimbursment
Malignant tumour
+∞
323.0
311
*
N03AX14
ATC
levetiracetam; systemic
122.8
198.7
205
33
WF002
NOMESCO Finland
Radical radiotherapy
2749.2
185.0
165
*
A04AA02
ATC
granisetron; systemic, transdermal
1335.6
180.6
163
*
C71.23
ICD-10 Finland
Malignant tumor of temporal lobe grade IV glioma
+∞
163.8
146
*
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
38.9
158.6
207
104
Z51.5
ICD-10 Finland
Palliative care
117.6
157.3
164
23
D43.0
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Brain, supratentorial
557.1
154.2
144
*
A03FA01
ATC
metoclopramide; systemic, rectal
23.8
153.2
246
242
182
Kela drug reimbursment
Brivaracetam, eslikarbazepin, gabapentin, lacosamide, levetiracetam, perampanel, pregabalin, tiagabin and zonisamide
136.4
145.1
149
17
111
Kela drug reimbursment
Epilepsy and comparable convulsive disorders
39.0
143.8
186
85
WF003
NOMESCO Finland
Adjuvant radiotherapy
940.1
140.6
130
*
9440/3-C71.9
ICD-O-3
Glioblastoma, NOS, of brain, NOS
+∞
139.8
126
*
C71.13
ICD-10 Finland
Malignant tumor of frontal lobe grade IV glioma
+∞
130.3
118
*
YA1AD
NOMESCO Finland
CT examination of head and neck for dose design of radiotherapy
+∞
119.8
109
*
9440/3-C71.2
ICD-O-3
Glioblastoma, NOS, of temporal lobe
+∞
111.7
102
*
AAG50
NOMESCO Finland
Stereotactic intracranial radiotherapy
+∞
105.9
97
*
C71.90
ICD-10 Finland
Malignant tumor in unspecified localization in the brain without histology
+∞
104.8
96
*
C71.20
ICD-10 Finland
Malignant tumor in temporal lobe without histology
+∞
103.6
95
*
ZXC95
NOMESCO Finland
Use of surgical navigator
190.4
100.3
101
7
WB103
NOMESCO Finland
Simple adjuvant cytostatic therapy
+∞
95.6
88
*
9440/3-C71.1
ICD-O-3
Glioblastoma, NOS, of frontal lobe
+∞
93.4
86
*
XX3DW
NOMESCO Finland
Time consuming IT work
22.0
91.3
139
93
C71.2
ICD-10 Finland
Malignant neoplasm: Temporal lobe
+∞
85.4
79
*
A04AA01
ATC
ondansetron; systemic, rectal
51.0
84.4
101
26
C71.33
ICD-10 Finland
Malignant tumor of parietal lobe grade IV glioma
+∞
80.9
75
*
C71.10
ICD-10 Finland
Malignant tumor in frontal lobe without histology
+∞
80.9
75
*
ZX012
NOMESCO Finland
Radiotherapy with large shaped fields - isocentric therapy
200.9
80.3
81
5
C71.1
ICD-10 Finland
Malignant neoplasm: Frontal lobe
+∞
79.8
74
*
AA1DG
NOMESCO Finland
Very extensive MRI examination of brain with high intensity magnet
33.0
71.9
95
37
YX8VG
NOMESCO Finland
Stereotactic MRI exmaination with high intensity magnet for dose design of radiotherapy
210.1
69.4
70
*
ZX095
NOMESCO Finland
Combined chemoradiotherapy
+∞
68.7
64
*
WD105
NOMESCO Finland
Cystostatic therapy of methastized malignancy
766.5
68.0
65
*
AAG00
NOMESCO Finland
Stereotactic intracranial biopsy
+∞
64.3
60
*
YX8BD
NOMESCO Finland
Stereotactic extensive CT examination for dose design of radiotherapy
247.1
63.0
63
*
AA1AD
NOMESCO Finland
CT of head and brain
6.1
58.9
215
630
C71.30
ICD-10 Finland
Malignant tumor in parietal lobe without histology
+∞
58.8
55
*
J01EE01
ATC
sulfamethoxazole and trimethoprim; systemic
13.9
55.5
100
93
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
6.7
53.3
160
355
YA1BD
NOMESCO Finland
Extensive CT examination of head and neck for dose design of radiotherapy
202.1
52.2
53
*
G40.29
ICD-10 Finland
Localization-related (focal)(partial) symptomatic epilepsy and epileptic syndromes with complex partial seizures
33.7
52.1
68
24
9440/3-C71.3
ICD-O-3
Glioblastoma, NOS, of parietal lobe
+∞
50.0
47
*
G40.22
ICD-10 Finland
Complex partial epileptic seizure with secondary generalization
25.0
50.0
71
34
N02AA05
ATC
oxycodone; systemic
8.1
48.5
121
202
ZX050
NOMESCO Finland
Stereotactic radiotherapy
+∞
47.8
45
*
WZC00
NOMESCO Finland
Planning of intervention or health care consultation
5.2
47.4
192
596
N03AX18
ATC
lacosamide; systemic
92.5
45.0
49
6
D43.9
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Central nervous system, unspecified
172.0
44.8
46
*
C71.3
ICD-10 Finland
Malignant neoplasm: Parietal lobe
+∞
44.6
42
*
C71.83
ICD-10 Finland
Overall malignant tumor of the brain grade IV glioma
+∞
42.4
40
*
N74
ICPC
Malignant neoplasm nervous system
450.5
41.9
41
*
D43.2
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Brain, unspecified
+∞
41.3
39
*
WX882
NOMESCO Finland
High dependency care
16.4
37.9
62
44
ZXM40
NOMESCO Finland
Use of fluorescent substance
401.7
37.6
37
*
WZC30
NOMESCO Finland
Teaching
6.7
37.6
105
199
C71.99
ICD-10 Finland
Malignant tumor in unspecified localization in the brain other or unspecified histology
+∞
37.0
35
*
ZXC40
NOMESCO Finland
Use of ultrasound
88.5
36.5
40
5
ZX070
NOMESCO Finland
Intensity modified radiotherapy
377.7
35.5
35
*
YA1VG
NOMESCO Finland
MRI examination of head and neck with high intesity magnet for dose design of radiotherapy
377.7
35.5
35
*
A02BC02
ATC
pantoprazole; systemic
4.1
33.9
325
1980
WX402
NOMESCO Finland
General anaesthesia
5.4
33.8
114
271
AA1BG
NOMESCO Finland
Standard MRI examination of brain with high intensity magnet
6.8
33.6
92
168
N03AF02
ATC
oxcarbazepine; oral
13.6
32.9
58
49
AA1BD
NOMESCO Finland
Extensive CT of head and brain
18.6
31.0
48
29
N05CD08
ATC
midazolam; nasal, systemic
16.4
29.1
47
32
A28
ICPC
Limited function/disability NOS
4.6
28.7
115
323
C79.30
ICD-10 Finland
Secondary malignant tumor of the cerebrum
+∞
28.5
27
*
C71.93
ICD-10 Finland
Malignant tumor in an unspecified localization in the brain grade IV glioma
+∞
27.4
26
*
R56.8
ICD-10 Finland
Other and unspecified convulsions
8.0
27.0
64
93
JN4BD
NOMESCO Finland
Extensive body CT
8.0
26.4
62
89
C71.29
ICD-10 Finland
Malignant tumor in temporal lobe other or unspecified histology
+∞
26.3
25
*
ZX090
NOMESCO Finland
Other technic of radiotherapy
77.6
26.1
29
*
WF004
NOMESCO Finland
Palliative radiotherapy
277.0
26.0
26
*
ZXE20
NOMESCO Finland
More than three and less than five hours
4.7
25.5
97
255
A79
ICPC
Malignancy NOS
132.7
23.9
25
*
C71.43
ICD-10 Finland
Malignant tumor of the occipital lobe grade IV glioma
+∞
22.1
21
*
C71.8
ICD-10 Finland
Malignant neoplasm: Overlapping lesion of brain
+∞
22.1
21
*
G40.9
ICD-10 Finland
Epilepsy, unspecified
10.1
21.9
44
48
AA1CD
NOMESCO Finland
Very extensive CT of head and brain
18.8
21.7
33
19
A98
ICPC
Health maint/preventive medicine
0.3
21.1
268
3509
WX404
NOMESCO Finland
Intravenous generell anesthesy
3.6
20.9
110
380
TPH04
NOMESCO Finland
Cathetrisation of vein
3.3
20.7
123
467
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
3.6
20.5
106
362
C71.00
ICD-10 Finland
Malignant tumor of the cerebrum except lobes and ventricles without histology
+∞
19.9
19
*
9440/3-C71.0
ICD-O-3
Glioblastoma, NOS, of cerebrum
+∞
19.9
19
*
WD405
NOMESCO Finland
Simple antiboidy therapy of methastized malignancy
+∞
19.9
19
*
B01AB10
ATC
tinzaparin; parenteral
7.2
19.7
49
76
WZC20
NOMESCO Finland
Multidisciplinary treatment meeting
11.5
19.3
36
34
N05CF01
ATC
zopiclone; oral
2.7
19.1
173
863
C71.03
ICD-10 Finland
Malignant tumor of cerebellum except lobes and ventricles grade IV glioma
+∞
18.9
18
*
C71.40
ICD-10 Finland
Malignant tumor of the occipital lobe without histology
+∞
17.8
17
*
C71.80
ICD-10 Finland
Overall malignant tumor of the brain without histology
+∞
17.8
17
*
AAA10
NOMESCO Finland
Biopsy through craniotomy
+∞
17.8
17
*
ZXM00
NOMESCO Finland
Intraoperative use of ultrasonographic imaging
22.1
17.5
25
12
WX408
NOMESCO Finland
General anesthesy, balanced
2.9
17.4
131
576
WX872
NOMESCO Finland
Intensive care
5.2
17.0
54
115
D43.1
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Brain, infratentorial
+∞
16.8
16
*
C71.9
ICD-10 Finland
Malignant neoplasm: Brain, unspecified
+∞
16.8
16
*
C71.19
ICD-10 Finland
Malignant tumor of frontal lobe other or unspecified histology
+∞
16.8
16
*
166
Kela drug reimbursment
Dalteparin and tinzaparin (treatment for more than 6 months)
176.8
16.6
17
*
C71.22
ICD-10 Finland
Malignant tumor of temporal lobe grade III glioma
+∞
15.7
15
*
YX9AD
NOMESCO Finland
Other CT eamination for dose design of radiotherapy
+∞
15.7
15
*
G41.9
ICD-10 Finland
Status epilepticus, unspecified
29.9
15.3
20
7
9440/3-C71.8
ICD-O-3
Glioblastoma, NOS, of overlapping lesion of brain
+∞
14.7
14
*
8140/3-C61.9
ICD-O-3
Adenocarcinoma, NOS, of prostate gland
+∞
14.7
14
*
C61
ICD-10 Finland
Malignant neoplasm of prostate
155.2
14.6
15
*
XA800
NOMESCO Finland
Neuropsychological investigation
6.1
14.0
38
67
IAZ97
NOMESCO Finland
Psychiatric consultation in another specialty
35.3
13.6
17
5
R90.8
ICD-10 Finland
Other abnormal findings on diagnostic imaging of central nervous system
19.0
13.5
20
11
H53.4
ICD-10 Finland
Visual field defects
8.1
13.1
29
38
N03AB02
ATC
phenytoin; systemic
9.5
12.9
26
29
N76
ICPC
Neoplasm nervous system unspecified
72.1
12.7
14
*
G40.19
ICD-10 Finland
Localization-related (focal)(partial) symptomatic epilepsy and epileptic syndromes with simple partial seizures
33.2
12.7
16
5
G40.10
ICD-10 Finland
Simple partial seizures
33.2
12.7
16
5
TPH07
NOMESCO Finland
Cathetrisation of artery
3.9
12.6
54
155
WC105
NOMESCO Finland
Simple cytostatic therapy of local tumor recidive
+∞
12.6
12
*
9440/3-C71.4
ICD-O-3
Glioblastoma, NOS, of occipital lobe
+∞
12.6
12
*
115
Kela drug reimbursment
Breast cancer
+∞
12.6
12
*
N02AB03
ATC
fentanyl; nasal, sublingual, transdermal
8.9
12.5
26
31
R4120
NOMESCO Finland
Occupational therapy
4.0
12.4
50
136
JN4AD
NOMESCO Finland
Body CT examination
6.0
12.4
34
61
R4110
NOMESCO Finland
Physiotherapy
2.4
12.0
122
614
WX704
NOMESCO Finland
Intubation
4.0
12.0
48
130
XX9BW
NOMESCO Finland
Submitting image material and/or investigation material to authority or other institution
15.2
11.9
19
13
C71.21
ICD-10 Finland
Malignant tumor of temporal lobe grade II glioma
+∞
11.5
11
*
WF049
NOMESCO Finland
Radiotherapy of metastasis
+∞
11.5
11
*
R90.0
ICD-10 Finland
Intracranial space-occupying lesion
123.3
11.5
12
*
G40.12
ICD-10 Finland
Simple partial seizures with secondary generalization
44.6
11.0
13
*
N05BA09
ATC
clobazam; oral
28.9
10.8
14
5
WX110
NOMESCO Finland
Local anesthesy
2.0
10.7
271
1997
C71.39
ICD-10 Finland
Malignant tumor of parietal lobe other or unspecified histology
+∞
10.5
10
*
YX9BD
NOMESCO Finland
Other extensive CT eamination for dose design of radiotherapy
+∞
10.5
10
*
PJA12
NOMESCO Finland
Sentinel node biopsy
+∞
10.5
10
*
WD415
NOMESCO Finland
Demanding antibody therapy of methastized malignancy
+∞
10.5
10
*
C71.4
ICD-10 Finland
Malignant neoplasm: Occipital lobe
+∞
10.5
10
*
WX725
NOMESCO Finland
Noninvasive ventilation
5.0
10.2
32
68
N03AG01
ATC
valproic acid; systemic, rectal
4.0
9.7
38
101
N05BA04
ATC
oxazepam; oral
2.2
9.7
112
593
WF029
NOMESCO Finland
Radiotherapy of local residive tumor
+∞
9.4
9
*
C71.32
ICD-10 Finland
Malignant tumor of parietal lobe grade III glioma
+∞
9.4
9
*
C71.12
ICD-10 Finland
Malignant tumor of frontal lobe grade III glioma
+∞
9.4
9
*
C71.01
ICD-10 Finland
Malignant tumor of cerebellum except lobes and ventricles grade II glioma
+∞
9.4
9
*
XF400
NOMESCO Finland
ECG with 12 standard connections
2.4
9.2
85
404
AA1DM
NOMESCO Finland
Very extensive MRI examination of brain with 3 Tesla magnet
12.9
8.9
15
12
ZXD10
NOMESCO Finland
Scheduled procedure
1.9
8.9
160
1013
A10AB05
ATC
insulin aspart; parenteral (insulins and analog. for injection, fast-acting)
3.4
8.8
42
133
B01AB05
ATC
enoxaparin; parenteral
2.1
8.7
116
650
I26.9
ICD-10 Finland
Pulmonary embolism without mention of acute cor pulmonale
4.3
8.7
31
76
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
2.9
8.5
53
202
TKC20
NOMESCO Finland
Catheterisation of bladder
3.3
8.4
42
137
WB113
NOMESCO Finland
Multiple adjuvant cytostatic therapy
+∞
8.4
8
*
G93.6
ICD-10 Finland
Cerebral oedema
+∞
8.4
8
*
WB401
NOMESCO Finland
Simple antibody therapy of primary tumour
+∞
8.4
8
*
R41.0
ICD-10 Finland
Disorientation, unspecified
5.7
8.1
22
40
FN1AC
NOMESCO Finland
Angiography of heart and/or coronary arteries
0.4
7.9
27
674
ZXM20
NOMESCO Finland
Intraoperative use of computerised tomography
25.5
7.6
10
*
FB1BD
NOMESCO Finland
Extensive CT examination of arteria pulmonalis
3.2
7.6
38
125
N03AX23
ATC
brivaracetam; systemic
81.5
7.4
8
*
L02BA01
ATC
tamoxifen; oral
81.5
7.4
8
*
SPAT1245
SPAT
Provision of support and information to patient’s family members
4.0
7.3
28
74
G41.2
ICD-10 Finland
Complex partial status epilepticus
+∞
7.3
7
*
C71
ICD-10 Finland
Malignant neoplasm of brain
+∞
7.3
7
*
PJD52
NOMESCO Finland
Block dissection of axillary lymph nodes
+∞
7.3
7
*
C71.0
ICD-10 Finland
Malignant neoplasm: Cerebrum, except lobes and ventricles
+∞
7.3
7
*
C50.41
ICD-10 Finland
Malignant tumor of the upper outer quadrant of the mammary gland, ductal tumor
+∞
7.3
7
*
205
Kela drug reimbursment
Chronic hypertension
0.4
7.2
44
882
WX892
NOMESCO Finland
Monitored bed care
2.9
7.2
42
154
HAB40
NOMESCO Finland
Wedge excision of mammary gland
20.4
7.2
10
5
AAB00
NOMESCO Finland
Extirpation of intracranial lesion
7.2
7.1
16
23
R51.80
ICD-10 Finland
Headache
2.5
7.0
56
244
H02AB09
ATC
hydrocortisone; systemic
5.8
6.8
18
32
YX8AD
NOMESCO Finland
Stereotactic CT examination for dose design of radiotherapy
40.7
6.8
8
*
ZSA00
NOMESCO Finland
Procedure related to previous procedure classified in chapter A
17.0
6.8
10
6
CJE20
NOMESCO Finland
Phakoemulsification with implantation of artificial lens in posterior chamber
0.5
6.6
44
855
206
Kela drug reimbursment
Chronic coronary artery disease and dyslipidaemia associated with chronic coronary artery disease
0.4
6.6
22
556
ZXE10
NOMESCO Finland
More than one and less than three hours
1.8
6.5
142
936
XA400
NOMESCO Finland
EEG
11.3
6.3
11
10
Z25.8
ICD-10 Finland
Need for immunization against other specified single viral diseases
0.1
6.3
*
255
8090/3-C44.9
ICD-O-3
Basal cell carcinoma, NOS, of skin, NOS
+∞
6.3
6
*
1CD02
NOMESCO Finland
NA
+∞
6.3
6
*
C71.50
ICD-10 Finland
Malignant tumor of cerebral ventricle without histology
+∞
6.3
6
*
C50.21
ICD-10 Finland
Malignant tumor of the upper inner quadrant of the mammary gland,ductal tumor
+∞
6.3
6
*
C50.40
ICD-10 Finland
Malignant tumor of the upper outer quadrant of the mammary gland, no histological veryfication
+∞
6.3
6
*
D69.5
ICD-10 Finland
Secondary thrombocytopenia
27.1
6.2
8
*
G40.11
ICD-10 Finland
Simple partial epileptic seizure that develops into a complex partial seizure
27.1
6.2
8
*
C01DA14
ATC
isosorbide mononitrate; oral
0.3
6.2
15
439
R47.0
ICD-10 Finland
Dysphasia and aphasia
8.8
6.1
12
14
SAA02
NOMESCO Finland
Basic examination of mouth
0.6
6.1
130
1813
M75.1
ICD-10 Finland
Rotator cuff syndrome
0.4
6.1
29
637
AA5BD
NOMESCO Finland
CT of cerebral ischaemia
5.3
6.1
17
33
PA7AD
NOMESCO Finland
CT angiography of head and neck vasculature
4.7
6.1
19
42
AA1AG
NOMESCO Finland
Short MRI examination of brain with median intensity magnet
5.7
6.0
16
29
ZXE30
NOMESCO Finland
More than five and less than seven hours
3.3
6.0
28
88
Mortality – FinRegistry
↥This endpoint is excluded (different definition than used in FinnGen).
Relationships between endpoints
↥Index endpoint: C3_GBM_EXALLC – Brain glioblastoma, excluding all cancers (controls excluding all cancers)
GWS hits: 3
This endpoint is excluded (different definition than used in FinnGen).