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Malignant neoplasm of heart, mediastinum and pleura, excluding all cancers (controls excluding all cancers)

C3_HEART_MEDIASTINUM_PLEURA_EXALLC

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 C38
  • Hospital discharge: ICD-9 16[3-4]
  • Hospital discharge: ICD-8 163[0-1]
  • Cause of death: ICD-10 C38
  • Cause of death: ICD-9 16[3-4]
  • Cause of death: ICD-8 163[0-1]
  • Cause of death: excluded ICD-9 1640
  • Cancer registry: Topography ICD-O-3 C38
  • Cancer registry: Morphology ICD-O-3 ANY
  • Cancer registry: Behaviour codes 3

3 out of 7 registries used, show all original rules.

642

4. Check minimum number of events

None

642

5. Include endpoints

None

642

6. Filter based on genotype QC (FinnGen only)

642

Control definitions (FinnGen only)

Control exclude
C3_CANCER, C3_CANCER_WIDE_EXALLC

Extra metadata

First used in FinnGen datafreeze
DF12

Similar endpoints

List of similar endpoints to Malignant neoplasm of heart, mediastinum and pleura, excluding all cancers (controls excluding all cancers) based on the number of shared cases.

Venn diagram with an highlighted set fully inside another set Similar with more cases:

Venn diagram with a set fully inside an highlighted set Similar with less cases:

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

-FinnGen-

Key figures

All Female Male
Number of individuals 642 174 468
Unadjusted period prevalence (%) 0.17 0.06 0.21
Median age at first event (years) 68.81 61.10 71.68

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
410
Matched controls
4098
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
C45.0
ICD-10 Finland
Mesothelioma of pleura
+∞
307.3
255
*
130
Kela drug reimbursment
Malignant tumour
+∞
233.3
201
*
H02AB02
ATC
dexamethasone; systemic
406.4
195.3
182
8
J90
ICD-10 Finland
Pleural effusion, not elsewhere classified
73.8
189.8
213
59
9050/3-C38.4
ICD-O-3
Mesothelioma, malignant of pleura, NOS
+∞
135.0
122
*
A03FA01
ATC
metoclopramide; systemic, rectal
22.0
134.5
216
197
A04AA01
ATC
ondansetron; systemic, rectal
96.9
114.3
123
18
N02AA05
ATC
oxycodone; systemic
14.7
106.1
203
256
9052/3-C38.4
ICD-O-3
Epithelioid mesothelioma, malignant of pleura, NOS
+∞
103.6
95
*
JN4BD
NOMESCO Finland
Extensive body CT
26.0
97.4
140
80
GAC01
NOMESCO Finland
Endoscopic biopsy of pleura
576.8
95.5
91
*
WD125
NOMESCO Finland
Demanding cystostatic therapy of methastized malignancy
568.6
94.3
90
*
Z51.5
ICD-10 Finland
Palliative care
34.1
84.4
111
44
J94.8
ICD-10 Finland
Other specified pleural conditions
47.0
75.7
92
25
GA4YT
NOMESCO Finland
Puncture of pleura with ultrasound guidance
28.6
75.5
104
48
GAA10
NOMESCO Finland
Intercostal insertion of pleural drainage tube
52.9
74.1
88
21
117
Kela drug reimbursment
Leukaemia and other malignant diseases of the blood and bone marrow, and malignant diseases of the lymphatic tissue
46.4
60.0
73
19
A04AA02
ATC
granisetron; systemic, transdermal
643.0
58.1
56
*
GD1BD
NOMESCO Finland
Thorax extensive CT-examination
17.6
58.0
94
68
TGA30
NOMESCO Finland
Thoracocentesis
100.1
55.6
60
7
WF049
NOMESCO Finland
Radiotherapy of metastasis
+∞
52.2
49
*
WD105
NOMESCO Finland
Cystostatic therapy of methastized malignancy
+∞
52.2
49
*
R91
ICD-10 Finland
Abnormal findings on diagnostic imaging of lung
8.5
50.6
122
194
GA1AE
NOMESCO Finland
Ultrasound examination of thorax
22.6
47.7
70
37
GD5BD
NOMESCO Finland
Thorax and upper abdomen combined extensive CT examination of
32.1
47.7
63
23
L03AA13
ATC
pegfilgrastim; parenteral
+∞
46.8
44
*
GAC00
NOMESCO Finland
Biopsy of pleura
94.6
46.0
50
6
L03AA02
ATC
filgrastim; parenteral
245.5
43.8
44
*
C38.4
ICD-10 Finland
Malignant neoplasm: Pleura
+∞
43.5
41
*
WF004
NOMESCO Finland
Palliative radiotherapy
+∞
42.4
40
*
ZX012
NOMESCO Finland
Radiotherapy with large shaped fields - isocentric therapy
+∞
42.4
40
*
ZX120
NOMESCO Finland
Intravenous
9.3
39.0
86
114
UGC12
NOMESCO Finland
Flexible bronchoscopy
7.5
38.2
98
165
1BA04
NOMESCO Finland
NA
+∞
38.1
36
*
YG1BD
NOMESCO Finland
Extensive CT examination of thorax for dose design of radiotherapy
+∞
37.0
35
*
A04AA55
ATC
palonosetron, combinations; systemic
+∞
37.0
35
*
D38.3
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Mediastinum
66.5
36.9
42
7
JN4AD
NOMESCO Finland
Body CT examination
13.8
36.9
65
55
L01CA04
ATC
vinorelbine; systemic
+∞
33.8
32
*
WX302
NOMESCO Finland
Thoracal epidural anesthesy
18.4
33.4
52
32
GD1AA
NOMESCO Finland
Thorax X-ray examination
3.6
32.9
246
1211
9051/3-C38.4
ICD-O-3
Fibrous mesothelioma, malignant of pleura, NOS
+∞
32.7
31
*
WZC30
NOMESCO Finland
Teaching
6.8
32.7
89
161
C45.9
ICD-10 Finland
Mesothelioma, unspecified
+∞
31.7
30
*
C83.31
ICD-10 Finland
Diffuse lymphoma with large B cells
+∞
31.7
30
*
8140/3-C61.9
ICD-O-3
Adenocarcinoma, NOS, of prostate gland
+∞
30.6
29
*
WF003
NOMESCO Finland
Adjuvant radiotherapy
324.8
30.2
30
*
J94.9
ICD-10 Finland
Pleural condition, unspecified
115.3
30.1
32
*
GAA96
NOMESCO Finland
Other open or percutaneous drainage of pleural cavity
115.3
30.1
32
*
C61
ICD-10 Finland
Malignant neoplasm of prostate
155.5
28.0
29
*
WZC00
NOMESCO Finland
Planning of intervention or health care consultation
3.7
27.6
150
549
D38.2
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Pleura
149.7
27.0
28
*
GD1AD
NOMESCO Finland
Thorax CT examination
10.5
26.6
53
57
WD115
NOMESCO Finland
Multiple cystostatic therapy of methastized malignancy
+∞
26.3
25
*
XX3DW
NOMESCO Finland
Time consuming IT work
9.2
25.6
55
68
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
3.9
25.2
123
409
C79.8
ICD-10 Finland
Secondary malignant neoplasm of other specified sites
+∞
24.2
23
*
R84
ICPC
Malignant neoplasm bronchus/lung
+∞
24.2
23
*
YG1AD
NOMESCO Finland
CT examination of thorax for dose design of radiotherapy
+∞
24.2
23
*
ZX090
NOMESCO Finland
Other technic of radiotherapy
+∞
24.2
23
*
WW500
NOMESCO Finland
Blood transfusion
14.1
24.0
41
32
GD1CT
NOMESCO Finland
Biopsy of the lung with CT guidance
92.3
23.9
26
*
A06AH03
ATC
naloxegol; oral
132.6
23.9
25
*
GA4AT
NOMESCO Finland
Cathetrisation of pleural cavity with ultrasound guidance
35.8
23.7
30
9
C83.33
ICD-10 Finland
Primary medical lymphoma with large B cells
+∞
23.1
22
*
A04AD12
ATC
aprepitant; systemic
+∞
22.1
21
*
N02AB03
ATC
fentanyl; nasal, sublingual, transdermal
9.5
21.2
44
51
J18.9
ICD-10 Finland
Pneumonia, unspecified
2.9
21.1
165
762
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
4.8
21.1
75
182
WD405
NOMESCO Finland
Simple antiboidy therapy of methastized malignancy
+∞
21.0
20
*
C81.1
ICD-10 Finland
Nodular sclerosis classical Hodgkin lymphoma
+∞
21.0
20
*
Z51.1
ICD-10 Finland
Chemotherapy session for neoplasm
+∞
21.0
20
*
J01MA14
ATC
moxifloxacin; systemic
5.2
20.8
68
150
GD5AD
NOMESCO Finland
Thorax and upper abdomen combined CT examination of
44.2
20.7
25
6
GAA31
NOMESCO Finland
Thoracoscopy
60.7
20.1
23
*
GD1AT
NOMESCO Finland
Biopsy of the lung with ultrasound guidance
209.5
19.7
20
*
9679/3-C38.3
ICD-O-3
Mediastinal large B-cell lymphoma of mediastinum, NOS
+∞
18.9
18
*
WF002
NOMESCO Finland
Radical radiotherapy
73.4
18.9
21
*
GD1BA
NOMESCO Finland
Extensive X-ray examination of thorax
22.1
18.9
27
13
TPX10
NOMESCO Finland
Implantation of vascular injection port
20.5
18.4
27
14
H02AB06
ATC
prednisolone; systemic
2.5
18.1
217
1256
JN4CD
NOMESCO Finland
Very extensive body CT
14.6
18.0
30
22
WX408
NOMESCO Finland
General anesthesy, balanced
2.9
17.8
130
561
WD415
NOMESCO Finland
Demanding antibody therapy of methastized malignancy
+∞
17.8
17
*
9053/3-C38.4
ICD-O-3
Mesothelioma, biphasic, malignant of pleura, NOS
+∞
17.8
17
*
D70.82
ICD-10 Finland
Drug-induced neutropenia
187.6
17.6
18
*
J01MA12
ATC
levofloxacin; systemic
3.1
17.6
111
434
N02AA01
ATC
morphine; systemic, rectal
36.7
16.8
21
6
C38.3
ICD-10 Finland
Malignant neoplasm: Mediastinum, part unspecified
+∞
16.8
16
*
WZC20
NOMESCO Finland
Multidisciplinary treatment meeting
14.2
16.7
28
21
9663/3-C38.3
ICD-O-3
Hodgkin lymphoma, nodular sclerosis, NOS, of mediastinum, NOS
+∞
15.7
15
*
ZX070
NOMESCO Finland
Intensity modified radiotherapy
+∞
15.7
15
*
A79
ICPC
Malignancy NOS
+∞
15.7
15
*
116
Kela drug reimbursment
Prostate cancer
+∞
15.7
15
*
TK800
NOMESCO Finland
Hemodialysis
10.3
15.4
30
31
JN5DR
NOMESCO Finland
PET-CT of upper body metabolism
33.1
14.9
19
6
9680/3-C38.3
ICD-O-3
Diffuse large B-cell lymphoma, NOS, of mediastinum, NOS
+∞
14.7
14
*
GDD20
NOMESCO Finland
Extended pneumonectomy
+∞
14.7
14
*
WB113
NOMESCO Finland
Multiple adjuvant cytostatic therapy
+∞
14.7
14
*
L03AA14
ATC
lipegfilgrastim; parenteral
+∞
14.7
14
*
8000/3-C38.4
ICD-O-3
Neoplasm, malignant of pleura, NOS
+∞
14.7
14
*
C45.1
ICD-10 Finland
Mesothelioma of peritoneum
+∞
14.7
14
*
JN6AD
NOMESCO Finland
CT of torso and neck
44.1
14.2
17
*
TPH04
NOMESCO Finland
Cathetrisation of vein
2.7
14.2
111
492
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
5.0
14.1
46
101
D38.1
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Trachea, bronchus and lung
9.9
13.7
27
29
JN4JR
NOMESCO Finland
Whole body extensive metabolic PET with CT
+∞
13.6
13
*
GDA11
NOMESCO Finland
Thoracoscopic biopsy of lung
35.3
13.6
17
5
B01AB05
ATC
enoxaparin; parenteral
2.5
13.2
130
651
WX600
NOMESCO Finland
Single shot through catheter
17.4
13.1
20
12
FB1BD
NOMESCO Finland
Extensive CT examination of arteria pulmonalis
4.1
13.0
52
140
B01AB10
ATC
tinzaparin; parenteral
5.6
12.8
37
71
AA1BD
NOMESCO Finland
Extensive CT of head and brain
11.5
12.7
23
21
GAB10
NOMESCO Finland
Antero- or postero-lateral thoracotomy
72.1
12.7
14
*
GEA00
NOMESCO Finland
Mediastinoscopy
72.1
12.7
14
*
GAC43
NOMESCO Finland
Total decortication of pleura
+∞
12.6
12
*
C34.10
ICD-10 Finland
Malignant tumor of the upper lobe, bronchus or lung without histology
+∞
12.6
12
*
J92.0
ICD-10 Finland
Pleural plaque with presence of asbestos
6.1
12.5
34
60
R06.0
ICD-10 Finland
Dyspnoea
2.4
12.4
128
651
B03BA03
ATC
hydroxocobalamin; parenteral
4.0
12.3
50
137
WX602
NOMESCO Finland
Repeated or continuing anesthesia shots throug a catheter
4.9
12.1
40
89
N03AX16
ATC
pregabalin; oral
2.6
12.0
103
474
GAC30
NOMESCO Finland
Artificial pneumothorax
+∞
11.5
11
*
ZX080
NOMESCO Finland
Image guided radiotherapy
+∞
11.5
11
*
8090/3-C44.3
ICD-O-3
Basal cell carcinoma, NOS, of skin of other and unspecified parts of face
+∞
11.5
11
*
GDD96
NOMESCO Finland
Other pneumonectomy
+∞
11.5
11
*
GA2AT
NOMESCO Finland
Pleural biopsy with ultrasound guidance
+∞
11.5
11
*
R85
ICPC
Malignant neopl respiratory other
123.2
11.5
12
*
GA3AT
NOMESCO Finland
Pleural cytology with ultrasound guidance
123.2
11.5
12
*
R82
ICPC
Pleurisy/pleural effusion
123.2
11.5
12
*
C44.31
ICD-10 Finland
Basocellular carcinoma of the skin on another or unspecified part of the face
123.2
11.5
12
*
R4110
NOMESCO Finland
Physiotherapy
2.4
11.1
111
554
GAC97
NOMESCO Finland
Other endoscopic operation on pleura
61.6
10.7
12
*
N02AX02
ATC
tramadol; systemic, rectal
2.1
10.5
178
1114
XZZ00
NOMESCO Finland
Active surveillance of a diagnosed cancer
+∞
10.5
10
*
C45
ICD-10 Finland
Mesothelioma
+∞
10.5
10
*
WD135
NOMESCO Finland
Demanding cystostatic therapy of methastized malignancy
+∞
10.5
10
*
L02BB03
ATC
bicalutamide; oral
+∞
10.5
10
*
C79.5
ICD-10 Finland
Secondary malignant neoplasm of bone and bone marrow
+∞
10.5
10
*
YX9AD
NOMESCO Finland
Other CT eamination for dose design of radiotherapy
+∞
10.5
10
*
C85.9
ICD-10 Finland
Non-Hodgkin lymphoma, unspecified
+∞
10.5
10
*
A49.9
ICD-10 Finland
Bacterial infection, unspecified
3.0
10.4
64
241
QBC00
NOMESCO Finland
Removal of foreign body from skin of trunk or subcutaneous tissue
33.4
10.4
13
*
TPH90
NOMESCO Finland
Removal of fixed intravenous catheter
19.4
10.3
15
8
XF400
NOMESCO Finland
ECG with 12 standard connections
2.4
10.3
98
475
A02BC02
ATC
pantoprazole; systemic
2.0
10.0
245
1763
J86.9
ICD-10 Finland
Pyothorax without fistula
10.4
9.6
18
18
WW200
NOMESCO Finland
Immunization
6.9
9.6
23
35
1XC02
NOMESCO Finland
NA
30.8
9.4
12
*
GAC37
NOMESCO Finland
Endoscopic chemical pleurodesis
+∞
9.4
9
*
Z85.7
ICD-10 Finland
Personal history of other malignant neoplasms of lymphoid, haematopoietic and related tissues
+∞
9.4
9
*
C34.00
ICD-10 Finland
Malignant tumor of the main bronchus without histology
+∞
9.4
9
*
JN6BD
NOMESCO Finland
Extensive CT of torso and neck
+∞
9.4
9
*
C81.9
ICD-10 Finland
Hodgkin lymphoma, unspecified
+∞
9.4
9
*
WD325
NOMESCO Finland
Demanding therapy of methastized malignancy with biomodifiers
+∞
9.4
9
*
C83.9
ICD-10 Finland
Non-follicular (diffuse) lymphoma, unspecified
+∞
9.4
9
*
GD2FN
NOMESCO Finland
Lung ventilation distribution isotope examination (radiospirometry)
+∞
9.4
9
*
PJD41
NOMESCO Finland
Excision of cervical lymph nodes
37.5
9.1
11
*
L02AE02
ATC
leuprorelin; implant, parenteral
19.1
9.0
13
7
ZX112
NOMESCO Finland
Subcutaneous
19.1
9.0
13
7
TPH20
NOMESCO Finland
Insertion of central venous catheter through subclavian or brachiocephalic vein
7.9
8.7
19
25
XW000
NOMESCO Finland
Bone marrow biopsy
6.0
8.7
23
40
SPAT1109
SPAT
Analgesia with portable analgesic pump
28.1
8.5
11
*
EN1BD
NOMESCO Finland
Very extensive CT examination of mouth and soft tissues of neck
20.5
8.5
12
6
WD305
NOMESCO Finland
Simple therapy of methastized malignancy with biomodifiers
91.8
8.4
9
*
R50.9
ICD-10 Finland
Fever, unspecified
2.6
8.4
65
279
C78.2
ICD-10 Finland
Secondary malignant neoplasm of pleura
+∞
8.4
8
*
C38.8
ICD-10 Finland
Malignant neoplasm: Overlapping lesion of heart, mediastinum and pleura
+∞
8.4
8
*
YG1CD
NOMESCO Finland
Very extensive CT examination of thorax for dose design of radiotherapy
+∞
8.4
8
*
8000/3-C38.3
ICD-O-3
Neoplasm, malignant of mediastinum, NOS
+∞
8.4
8
*
C34.90
ICD-10 Finland
Malignant tumor in unspecified location in bronchus and lung without histology
+∞
8.4
8
*
8090/3-C44.9
ICD-O-3
Basal cell carcinoma, NOS, of skin, NOS
+∞
8.4
8
*
WX404
NOMESCO Finland
Intravenous generell anesthesy
2.4
8.3
72
331
Z31.6
ICD-10 Finland
General counselling and advice on procreation
34.0
8.1
10
*
PJ2AT
NOMESCO Finland
Biopsy of lymphnode with ultrasound guidance
81.4
7.4
8
*
C83.39
ICD-10 Finland
Diffuse non-Hodgkin's large cell lymphoma UNS
+∞
7.3
7
*
C34.80
ICD-10 Finland
Malignant overall tumor of bronchus and lung without histology
+∞
7.3
7
*
C38.1
ICD-10 Finland
Malignant neoplasm: Anterior mediastinum
+∞
7.3
7
*
C96.9
ICD-10 Finland
Malignant neoplasm of lymphoid, haematopoietic and related tissue, unspecified
+∞
7.3
7
*
L01CB01
ATC
etoposide; systemic
+∞
7.3
7
*
GA2CT
NOMESCO Finland
Pleural biopsy with CT guidance
+∞
7.3
7
*
J38.0
ICD-10 Finland
Paralysis of vocal cords and larynx
10.3
7.1
13
13
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
2.5
6.8
53
229
NK6AN
NOMESCO Finland
Total body bone isotope imaging
40.7
6.8
8
*
J93.9
ICD-10 Finland
Pneumothorax, unspecified
17.0
6.8
10
6
PH1AE
NOMESCO Finland
Ultrasound examination of upper extremity veins
12.5
6.6
11
9
AA1CD
NOMESCO Finland
Very extensive CT of head and brain
12.5
6.6
11
9
Y77
ICPC
Malignant neoplasm prostate
70.8
6.4
7
*
TPH30
NOMESCO Finland
Insertion of central venous catheter through periferal vein
14.6
6.4
10
7
GAC20
NOMESCO Finland
Excision or destruction of lesion of pleura
+∞
6.3
6
*
GAC96
NOMESCO Finland
Other operation on pleura
+∞
6.3
6
*
C83.3
ICD-10 Finland
Diffuse large B-cell lymphoma
+∞
6.3
6
*
WB121
NOMESCO Finland
Demanding neoadjuvant cytostatic therapy
+∞
6.3
6
*
C45.7
ICD-10 Finland
Mesothelioma of other sites
+∞
6.3
6
*
Z51.0
ICD-10 Finland
Radiotherapy session
+∞
6.3
6
*
WB103
NOMESCO Finland
Simple adjuvant cytostatic therapy
+∞
6.3
6
*
XX9CD
NOMESCO Finland
Very extensive complementary CT
+∞
6.3
6
*
KEC00
NOMESCO Finland
Retropubic radical prostatectomy
+∞
6.3
6
*
C85.1
ICD-10 Finland
B-cell lymphoma, unspecified
+∞
6.3
6
*
C78.0
ICD-10 Finland
Secondary malignant neoplasm of lung
+∞
6.3
6
*
C38.2
ICD-10 Finland
Malignant neoplasm: Posterior mediastinum
+∞
6.3
6
*
TGD00
NOMESCO Finland
Needle biopsy of lung
+∞
6.3
6
*
D38.4
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Thymus
+∞
6.3
6
*
GD5CD
NOMESCO Finland
Thorax and upper abdomen combined very extensive CT examination of
27.1
6.2
8
*
N06DA02
ATC
donepezil; oral
0.1
6.2
*
184
R4190
NOMESCO Finland
Nutritional therapy
10.2
6.1
11
11

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
152
40
49.48
254.39
2.2
1.5
—
—
—
0
0
201
126
22.77
247.33
1.7
1.2
—
—
—
0
0
151
47
41.70
241.31
1.8
1.4
—
—
—
0
0
154
54
37.20
237.39
2.0
1.5
1910.1
1977.9
e6/l
0.04
126
38
149
50
38.50
232.67
1.9
1.5
53613.9
159592.8
e6/l
0.43
113
31
112
45
29.94
163.34
1.9
1.5
—
—
—
0
0
63
23
30.26
93.89
1.5
1.4
—
—
—
0
0
138
230
7.37
82.93
2.2
1.3
16.8
4.2
ug/l
0.50
108
172
216
646
4.53
66.63
2.3
2.1
—
—
—
0
0
211
640
4.42
63.55
5.6
2.7
0.8
0.8
mmol/l
8.33
201
590
33
12
28.94
48.70
1.3
1.0
—
—
—
0
0
271
1325
2.81
34.65
6.5
4.0
—
—
—
0
0
278
1380
2.79
34.48
8.5
5.2
—
—
—
0
0
330
1894
2.53
29.11
9.0
5.1
0.6
0.6
%
2.55
325
1745
41
57
7.62
28.28
2.4
2.8
—
—
—
0
0
332
1952
2.45
27.23
9.0
5.1
2.3
3.0
%
6.32
327
1791
332
1958
2.44
26.96
9.2
5.4
9.5
8.8
%
2.68
325
1808
244
1257
2.52
26.61
2.8
1.6
—
—
—
0
0
334
2001
2.39
25.84
9.1
5.3
20.6
26.3
%
15.25
328
1834
96
302
3.56
25.75
1.3
1.1
—
—
—
0
0
373
2349
2.40
25.69
20.3
5.9
4.7
4.5
e9/l
0.48
341
2025
341
2102
2.33
24.17
8.4
4.9
0.7
0.6
e9/l
4.90
305
1793
281
4130
0.43
23.77
4.8
6.6
40.5
41.0
mmol/mol
0.44
246
3769
341
2112
2.31
23.77
8.4
5.0
0.0
0.0
e9/l
2.10
307
1811
342
2148
2.27
22.71
8.5
5.1
1.5
1.8
e9/l
10.45
309
1867
342
2180
2.22
21.50
9.2
5.1
0.2
0.2
e9/l
3.28
312
1884
191
955
2.42
21.48
14.3
4.4
—
—
—
0
0
318
4390
0.45
21.16
3.5
5.3
2.6
2.5
mmol/l
0.84
267
3960
19
13
15.03
21.13
5.9
1.9
3.4
4.0
nmol/l
0.18
19
13
301
4236
0.46
21.02
3.3
4.7
1.4
1.4
mmol/l
0.36
258
3818
229
1268
2.25
20.09
5.5
3.0
7.4
7.4
ph
0.07
34
208
310
4287
0.46
19.96
3.3
4.7
4.5
4.4
mmol/l
0.94
268
3893
301
1880
2.13
19.28
7.0
3.7
31.5
35.1
g/l
15.96
286
1723
68
207
3.56
19.02
1.3
1.4
—
—
—
0
0
195
1032
2.28
18.90
9.1
3.6
86.1
81.8
%
1.77
190
1002
25
31
8.35
18.88
2.4
1.2
—
—
—
0
0
24
30
8.27
18.00
2.4
2.8
1.1
1.1
e9/l
0.04
16
16
18
15
12.32
17.87
2.2
3.0
0.1
0.2
e9/l
0.91
18
15
305
1956
2.07
17.79
6.6
11.0
1.2
1.4
inr
4.09
63
531
222
1266
2.15
17.68
3.3
2.1
—
—
—
0
0
332
2204
2.05
17.52
9.4
5.8
1.2
1.2
mmol/l
0.89
298
1866
112
477
2.63
17.39
1.5
1.5
—
—
—
0
0
308
2009
2.02
16.87
9.2
5.6
1.2
1.2
mmol/l
0.69
300
1774
299
4094
0.50
16.82
3.1
4.2
1.2
1.3
mmol/l
0.41
252
3653
161
847
2.20
15.43
6.4
2.1
2.5
2.4
mmol/l
11.05
147
715
178
976
2.14
15.36
3.1
2.1
—
—
—
0
0
231
1415
1.99
14.61
8.0
2.0
2.4
2.3
mmol/l
1.28
211
1156
20
26
7.91
14.49
2.3
3.1
11.7
9.8
%
—
6
13
14
11
12.99
14.29
1.9
3.7
—
—
—
0
0
14
11
12.99
14.29
2.0
3.7
5.1
6.8
%
0.26
14
11
13
11
12.04
12.67
2.8
1.2
—
—
—
0
0
34
86
4.12
12.33
1.8
1.4
9.3
7.6
u/l
0.40
28
72
343
4320
0.56
11.68
4.1
4.9
6.1
6.1
mmol/l
0.25
299
3850
19
30
6.50
11.60
1.3
1.1
—
—
—
0
0
83
1622
0.44
11.33
3.0
4.0
1.9
9.2
mg/mmol
9.32
45
1059
82
1582
0.45
10.70
2.3
3.2
8.7
7.7
mmol/l
1.09
66
1308
79
1536
0.45
10.49
2.3
3.3
16.3
188.5
mg/l
1.98
45
1009
62
261
2.52
9.72
4.9
4.6
—
—
—
0
0
14
8
17.85
9.43
3.8
1.3
75.6
62.5
nmol/l
—
14
8
107
584
2.00
8.94
9.0
7.6
1.7
1.4
mmol/l
0.47
95
446
100
540
2.01
8.59
1.6
1.7
—
—
—
0
0
72
345
2.22
8.44
5.2
4.4
5.6
5.2
kpa
1.55
66
318
106
590
1.95
8.35
5.9
5.0
1.0
1.0
mmol/l
0.11
100
533
13
20
6.61
8.09
2.6
1.6
463.8
1008.2
e6/l
—
5
9
264
1928
1.63
8.04
5.4
3.7
—
—
—
0
0
420
4861
0.61
7.87
48.0
20.3
125.3
135.8
g/l
28.11
411
4739
420
4861
0.61
7.87
47.4
20.2
7.6
6.9
e9/l
3.13
403
4668
325
3991
0.62
7.86
5.2
4.2
2.3
2.0
mu/l
1.13
287
3558
73
362
2.15
7.85
1.5
1.5
—
—
—
0
0
420
4859
0.61
7.82
47.3
20.2
4.3
4.5
e12/l
12.25
403
4662
420
4858
0.61
7.80
47.2
20.1
29.7
30.5
pg
12.38
410
4739
420
4858
0.61
7.80
47.2
20.1
90.7
91.6
fl
3.18
410
4739
420
4856
0.61
7.75
47.3
20.2
278.8
236.7
e9/l
16.22
405
4682
64
305
2.22
7.60
5.9
3.6
1.6
0.7
%
1.27
35
74
180
1209
1.68
7.53
2.9
2.9
—
—
—
0
0
13
22
6.01
7.40
5.3
3.4
—
—
—
0
0
29
95
3.15
7.25
1.6
2.0
9.0
11.9
mg/l
1.24
29
88
199
1385
1.63
7.20
3.0
3.0
23.8
123.2
e6/l
1.38
158
1069
49
217
2.36
6.91
5.7
5.1
26.2
24.8
mmol/l
1.97
49
198
60
290
2.18
6.89
6.2
3.7
0.2
0.0
%
1.10
34
63
34
126
2.79
6.87
4.4
4.0
—
—
—
0
0
16
36
4.53
6.74
6.1
3.0
—
—
—
0
0
148
975
1.67
6.56
5.1
3.9
155.9
407.3
ng/l
1.58
134
816
56
270
2.18
6.47
4.9
3.7
0.8
0.6
%
0.29
25
54
182
1267
1.61
6.47
2.9
2.9
0.6
0.4
e6/l
0.61
140
951
27
92
3.02
6.34
3.1
3.0
—
—
—
0
0
135
876
1.69
6.32
2.3
1.7
1.6
1.3
mg/l
0.63
113
673
51
240
2.22
6.26
14.3
12.3
—
—
—
0
0
80
448
1.90
6.15
1.6
1.5
—
—
—
0
0
146
2072
0.62
6.06
1.5
2.1
93.5
92.1
pmol/l
0.12
83
1096
21
65
3.31
5.77
2.8
2.0
123.3
8155.8
u/l
—
10
19
249
1900
1.51
5.76
16.1
8.0
0.0
0.0
e9/l
0.41
198
1538
179
2403
0.65
5.68
4.3
4.1
2.4
2.2
ug/l
0.29
148
2126
23
77
3.06
5.58
1.5
2.6
—
—
—
0
0
62
329
1.98
5.58
1.4
1.4
—
—
—
0
0
137
920
1.62
5.56
2.4
2.5
553.1
569.4
mosm/kgh2o
0.37
123
755
70
391
1.89
5.42
12.4
7.9
—
—
—
0
0
14
34
4.19
5.38
5.2
3.2
—
—
—
0
0
330
2690
1.47
5.37
8.4
4.7
6.6
6.9
mmol/l
2.73
320
2509
76
438
1.83
5.34
2.9
2.3
6.5
9.2
umol/l
1.25
68
377
391
3299
1.47
5.29
16.7
5.1
85.4
76.4
u/l
3.52
384
3021
57
1008
0.52
5.27
4.0
3.9
1.0
1.0
kg/l
—
7
158
409
4639
0.67
5.23
19.9
8.9
25.3
25.4
u/l
0.06
400
4402
398
4537
0.68
5.22
28.1
13.5
—
—
—
0
0
10
19
5.33
5.05
1.2
1.1
—
—
—
0
0
53
276
2.00
5.04
6.1
3.8
0.1
0.0
%
0.77
30
56
412
4653
0.68
4.98
34.7
17.3
4.0
4.0
mmol/l
0.18
401
4489
412
4644
0.69
4.82
34.6
17.2
138.4
139.7
mmol/l
14.75
403
4485
21
73
2.94
4.80
4.9
2.9
63.0
58.5
%
0.71
21
73
24
90
2.73
4.80
2.8
2.1
14.1
16.0
%
0.92
11
47
17
459
0.35
4.68
2.0
1.6
—
—
—
0
0
85
1304
0.60
4.66
2.5
3.2
—
—
—
0
0
15
44
3.47
4.49
1.4
1.4
—
—
—
0
0
15
44
3.47
4.49
1.4
1.4
—
—
—
0
0
15
44
3.47
4.49
1.4
1.4
—
—
—
0
0
15
44
3.47
4.49
1.4
1.4
—
—
—
0
0
207
1590
1.45
4.38
3.4
3.4
114.3
90.0
e6/l
0.16
162
1142
20
72
2.83
4.32
4.1
2.5
4.1
4.4
e9/l
0.25
20
72
8
10
8.08
4.07
1.0
1.0
—
—
—
0
0
19
70
2.77
3.95
1.2
1.7
—
—
—
0
0
12
34
3.58
3.78
1.7
1.1
—
—
—
0
0
165
2110
0.71
3.60
3.4
3.6
0.0
0.0
estimate
0.00
40
362
269
3176
0.74
3.53
4.8
3.3
14.9
14.9
pmol/l
0.02
246
2810
121
873
1.48
3.48
6.2
4.0
—
—
—
0
0
127
1684
0.69
3.37
3.4
3.4
—
—
—
0
0
169
2134
0.72
3.36
3.3
3.6
0.0
0.0
estimate
0.00
39
358
132
978
1.44
3.30
2.6
2.3
4.0
4.2
e6/l
0.14
123
846
167
2102
0.72
3.23
4.6
4.8
0.0
0.0
estimate
0.00
39
362
316
3619
0.75
3.23
41.8
18.5
327.9
332.5
g/l
14.15
310
3580
12
38
3.20
3.22
1.4
1.2
—
—
—
0
0
89
1252
0.66
3.20
1.3
1.6
21.7
19.9
nmol/l
0.48
81
1045
88
605
1.53
3.19
2.0
2.4
19.9
23.1
%
1.32
83
515
200
1607
1.36
3.08
3.4
3.1
1275.8
1828.1
ng/l
1.63
187
1374
6
8
7.56
3.06
1.5
1.8
—
—
—
0
0
8
16
5.05
3.06
1.3
1.1
—
—
—
0
0
77
1105
0.66
3.05
1.5
1.8
568.0
6404907.5
pmol/l
0.50
60
890
12
40
3.04
2.98
1.4
1.1
—
—
—
0
0
19
82
2.36
2.94
1.4
1.2
—
—
—
0
0
100
723
1.45
2.84
2.8
2.8
2.6
1.8
e6/l
0.34
53
396
100
726
1.45
2.78
2.0
2.3
10.0
12.8
umol/l
4.02
94
660
73
502
1.51
2.66
1.4
1.3
367.1
552.7
titre
0.86
17
120
77
1072
0.68
2.60
1.7
1.8
1279.6
1152.9
nmol/l
0.45
53
800
171
1374
1.33
2.58
3.5
2.2
53.2
57.3
u/l
1.05
164
1258
36
210
1.76
2.52
1.1
1.3
—
—
—
0
0
16
70
2.32
2.43
1.3
1.3
—
—
—
0
0
19
90
2.14
2.41
1.8
1.6
358.5
261.9
mu/l
0.75
19
82
20
97
2.10
2.39
3.1
2.8
—
—
—
0
0
11
40
2.78
2.38
2.4
1.2
—
—
—
0
0
13
52
2.53
2.37
2.5
1.5
89.6
89.8
%
0.07
13
52
76
1042
0.69
2.36
2.9
3.6
—
—
—
0
0
140
1107
1.34
2.34
1.5
1.4
—
—
—
0
0
17
78
2.21
2.33
2.0
1.2
—
—
—
0
0
88
650
1.41
2.24
2.0
2.3
2.1
2.2
g/l
1.80
83
594
12
48
2.53
2.19
1.2
1.2
—
—
—
0
0
63
439
1.48
2.18
6.1
3.6
—
—
—
0
0
20
101
2.01
2.17
1.5
1.2
—
—
—
0
0
103
1321
0.74
2.13
2.8
2.8
0.8
0.8
ug/l
0.25
70
931
11
43
2.59
2.10
1.2
1.3
92.5
61.1
pmol/l
0.90
11
43
6
15
4.03
2.04
1.2
1.1
—
—
—
0
0
70
508
1.42
1.98
1.8
1.8
—
—
—
0
0
16
306
0.51
1.95
1.9
2.9
—
—
—
0
0
48
325
1.52
1.92
1.2
1.4
—
—
—
0
0
92
1182
0.74
1.92
3.6
3.8
0.0
0.0
estimate
0.00
37
347
8
28
2.88
1.86
1.1
1.1
—
—
—
0
0
23
389
0.58
1.86
1.2
1.3
—
—
—
0
0
24
138
1.77
1.82
4.1
3.3
26.3
24.8
mmol/l
0.65
17
119
20
109
1.86
1.79
2.4
2.0
115.8
132.2
g/l
1.14
11
79
26
416
0.61
1.71
1.6
2.1
156.1
185.3
ug/g
0.21
20
316
52
368
1.45
1.70
3.9
5.8
—
—
—
0
0
323
2918
1.22
1.69
4.3
4.3
187.3
420.1
e6/l
—
10
48
59
796
0.72
1.68
1.2
1.2
1.0
1.4
u/ml
—
10
214
81
624
1.34
1.63
3.8
2.1
1.6
1.7
%
0.22
73
548
5
14
3.59
1.62
1.4
1.1
—
—
—
0
0
8
32
2.52
1.60
1.8
1.8
—
—
—
0
0
0
42
0.00
1.53
0.0
1.0
—
340.9
—
0
25
353
3813
0.84
1.47
35.7
15.4
38.4
39.4
%
1.54
253
2409
141
1189
1.24
1.42
3.8
2.5
295.0
8679.7
umol/l
5.48
126
1002
413
4392
0.83
1.41
37.5
13.9
43.1
26.6
mg/l
12.52
387
3420
10
46
2.19
1.40
1.4
1.2
—
—
—
0
0
6
133
0.45
1.29
2.2
1.6
—
—
—
0
0
12
214
0.55
1.23
1.3
1.4
—
—
—
0
0
38
272
1.42
1.22
3.4
3.0
5.3
4.1
e9/l
1.03
28
196
329
3539
0.86
1.18
41.5
16.3
14.5
13.7
%
15.47
321
3441
63
494
1.31
1.16
2.5
2.7
9.5
7.1
ug/l
0.29
54
421
9
162
0.55
1.10
17.0
10.8
—
—
—
0
0
7
32
2.20
1.08
1.0
1.2
—
—
—
0
0
43
325
1.35
1.04
1.8
1.5
—
—
—
0
0
20
130
1.56
1.03
1.0
1.2
—
—
—
0
0
7
34
2.07
1.03
2.6
2.9
—
—
—
0
0
9
47
1.93
1.02
1.1
1.0
—
—
—
0
0
5
23
2.18
0.98
1.8
2.3
—
—
—
0
0
7
36
1.95
0.97
1.7
1.8
—
—
—
0
0
61
490
1.27
0.97
2.4
3.3
182.5
270.2
ng/l
1.66
52
458
16
246
0.64
0.96
2.2
2.4
—
—
—
0
0
162
1815
0.86
0.95
2.7
2.7
420.3
140.2
ug/l
3.97
150
1635
17
256
0.65
0.94
1.0
1.2
—
—
—
0
0
10
170
0.58
0.91
2.0
1.4
—
—
—
0
0
28
203
1.40
0.88
1.1
1.2
34.1
104.6
iu/ml
—
6
80
16
104
1.55
0.85
2.1
1.3
37.7
74.4
e6/l
—
9
90
16
104
1.55
0.85
2.1
1.4
24.4
1257.6
e6/l
—
9
91
95
1100
0.84
0.83
3.5
3.2
—
—
—
0
0
0
24
0.00
0.79
0.0
1.0
—
—
—
0
0
0
25
0.00
0.79
0.0
3.3
—
30.8
—
0
17
0
25
0.00
0.79
0.0
3.4
—
—
—
0
0
10
162
0.61
0.78
2.1
1.8
—
—
—
0
0
15
99
1.53
0.76
2.1
1.3
4.2
4.1
mmol/l
0.12
15
91
16
108
1.49
0.74
9.5
2.7
1.1
1.7
mg/l
3.62
16
95
5
26
1.93
0.70
1.2
1.5
—
—
—
0
0
7
121
0.57
0.67
1.3
1.8
37.7
41.8
nmol/l
—
7
113
21
282
0.74
0.66
1.1
1.2
—
—
—
0
0
8
49
1.64
0.62
1.0
1.2
—
—
—
0
0
5
30
1.67
0.61
1.8
2.5
—
—
—
0
0
0
20
0.00
0.60
0.0
3.5
—
—
—
0
0
0
21
0.00
0.60
0.0
11.2
—
808.6
—
0
21
0
21
0.00
0.60
0.0
15.5
—
1355.6
—
0
21
0
23
0.00
0.58
0.0
1.1
—
—
—
0
0
0
23
0.00
0.58
0.0
1.1
—
138.3
—
0
23
6
35
1.72
0.58
1.3
1.2
—
—
—
0
0
6
36
1.67
0.57
1.2
1.6
—
—
—
0
0
8
55
1.46
0.56
1.1
1.0
—
—
—
0
0
34
416
0.81
0.56
2.2
3.1
—
—
—
0
0
17
228
0.74
0.55
5.2
4.6
—
—
—
0
0
120
1320
0.89
0.55
2.8
3.1
—
—
—
0
0
12
82
1.47
0.54
1.2
1.7
—
—
—
0
0
54
461
1.19
0.54
4.1
2.1
56.8
66.5
e9/l
1.21
37
366
6
100
0.60
0.52
2.3
2.0
—
—
—
0
0
81
718
1.15
0.52
1.9
1.3
2.0
2.7
g/l
2.06
57
414
130
1413
0.90
0.48
5.0
4.2
—
—
—
0
0
7
48
1.46
0.47
1.4
1.2
—
—
—
0
0
42
357
1.19
0.46
3.3
3.5
—
—
—
0
0
6
94
0.63
0.42
1.0
1.4
—
—
—
0
0
0
15
0.00
0.41
0.0
1.0
—
18.8
—
0
9
0
18
0.00
0.40
0.0
8.8
—
0.6
—
0
18
304
3157
0.93
0.40
4.1
4.1
—
—
—
0
0
5
35
1.43
0.39
1.2
1.1
—
—
—
0
0
5
35
1.43
0.39
2.0
2.3
—
—
—
0
0
0
19
0.00
0.39
0.0
1.1
—
38.0
—
0
11
9
70
1.29
0.36
1.0
1.2
—
—
—
0
0
6
42
1.43
0.35
1.8
1.3
—
—
—
0
0
15
117
1.29
0.35
1.3
1.2
—
—
—
0
0
6
45
1.34
0.34
1.2
1.4
—
—
—
0
0
26
219
1.20
0.33
3.4
6.3
1.6
1.7
%
0.12
26
210
22
259
0.84
0.28
3.2
3.2
—
—
—
0
0
13
162
0.80
0.28
1.6
2.4
0.3
0.2
g/l
—
6
52
9
72
1.25
0.25
3.0
2.4
—
—
—
0
0
6
85
0.70
0.24
1.0
1.1
35.4
20.4
u/l
—
6
74
38
343
1.11
0.22
2.1
1.9
0.2
0.2
g/l
0.87
38
299
0
10
0.00
0.21
0.0
7.3
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
0.7
—
0
5
0
12
0.00
0.21
0.0
9.4
—
—
—
0
0
0
13
0.00
0.21
0.0
1.2
—
—
—
0
0
17
146
1.17
0.19
3.4
3.6
—
—
—
0
0
24
213
1.13
0.18
6.2
6.5
0.8
0.9
%
0.53
24
204
6
53
1.13
0.18
1.2
1.4
—
—
—
0
0
6
53
1.13
0.18
1.2
1.4
—
—
—
0
0
319
3254
0.96
0.18
4.8
3.9
23.3
12.6
mm/h
9.69
305
2939
12
100
1.20
0.18
4.3
1.4
—
—
—
0
0
20
176
1.14
0.17
1.9
1.8
—
—
—
0
0
7
63
1.11
0.17
1.1
1.1
—
—
—
0
0
58
544
1.07
0.17
1.2
1.2
—
—
—
0
0
198
1936
1.03
0.12
4.6
4.1
40.6
88.0
ng/l
1.02
160
1451
26
239
1.09
0.12
1.5
1.3
—
—
—
0
0
58
606
0.95
0.10
1.2
1.3
30.1
12.9
u/ml
0.41
14
220
5
46
1.09
0.09
1.2
1.2
—
—
—
0
0
10
114
0.88
0.09
1.0
1.1
—
—
—
0
0
6
56
1.07
0.08
1.2
1.5
—
—
—
0
0
12
107
1.12
0.08
1.3
1.1
—
—
—
0
0
24
256
0.94
0.08
1.3
1.5
—
—
—
0
0
32
334
0.96
0.05
2.3
3.9
80.1
98.0
ng/l
0.47
26
292
41
400
1.03
0.02
6.9
3.1
4.9
4.4
kpa
0.50
41
382
77
781
0.98
0.02
18.0
29.9
1.3
1.5
inr
—
8
113
16
156
1.03
0.00
1.2
1.2
—
—
—
0
0
11
113
0.97
0.00
9.5
10.0
102.5
105.8
mmol/l
1.39
11
105
11
113
0.97
0.00
9.5
10.0
10.9
11.6
mmol/l
0.31
11
105
63
634
0.99
0.00
1.2
1.3
19.1
42.2
iu/ml
1.94
12
187
26
258
1.01
0.00
3.2
2.6
0.2
0.2
e6/l
0.04
26
251
11
111
0.99
0.00
2.0
1.6
—
—
—
0
0
306
3064
1.00
0.00
4.2
4.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.6
—
—
—
0
0
0
6
0.00
0.00
0.0
1.5
—
—
—
0
0
9
99
0.91
0.00
6.7
3.1
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
127
1270
1.00
0.00
1.9
2.1
3.5
2.9
mg/l
1.73
107
1062
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.6
—
—
—
0
0
0
7
0.00
0.00
0.0
1.9
—
16.9
—
0
7
0
7
0.00
0.00
0.0
6.3
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
170.3
—
0
6
7
75
0.93
0.00
8.3
2.4
75.1
62.1
%
—
7
75
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0

Mortality – FinRegistry

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

Relationships between endpoints

Index endpoint: C3_HEART_MEDIASTINUM_PLEURA_EXALLC – Malignant neoplasm of heart, mediastinum and pleura, excluding all cancers (controls excluding all cancers)

GWS hits: -

This endpoint is excluded from FinRegistry analyses (omitted endpoint).