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Malignant neoplasm of heart, mediastinum and pleura

C3_HEART_MEDIASTINUM_PLEURA

Heart neoplasm: Tumors in any part of the heart. They include primary cardiac tumors and metastatic tumors to the heart. Their interference with normal cardiac functions can cause a wide variety of symptoms including HEART FAILURE; CARDIAC ARRHYTHMIAS; or EMBOLISM.

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Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Cause of death: ICD-10 C38
  • Cause of death: ICD-9 16[3-4]
  • Cause of death: ICD-8 163[0-1]
  • Cause of death: excluded ICD-9 1640
  • Cancer registry: Topography ICD-O-3 C38
  • Cancer registry: Morphology ICD-O-3 ANY
  • Cancer registry: Behaviour codes 3

2 out of 7 registries used, show all original rules.

427

4. Check minimum number of events

None

427

5. Include endpoints

None

427

6. Filter based on genotype QC (FinnGen only)

427

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF9

Similar endpoints

List of similar endpoints to Malignant neoplasm of heart, mediastinum and pleura based on the number of shared cases.

Venn diagram with an highlighted set fully inside another set Similar with more cases:

Venn diagram with a set fully inside an highlighted set Similar with less cases:

None

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

-FinnGen-

Key figures

All Female Male
Number of individuals 427 112 315
Unadjusted period prevalence (%) 0.11 0.04 0.14
Median age at first event (years) 69.61 62.71 72.06

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
410
Matched controls
4098
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
C45.0
ICD-10 Finland
Mesothelioma of pleura
7931.8
305.0
255
*
J90
ICD-10 Finland
Pleural effusion, not elsewhere classified
44.9
169.4
213
96
9050/3-C38.4
ICD-O-3
Mesothelioma, malignant of pleura, NOS
+∞
135.1
122
*
130
Kela drug reimbursment
Malignant tumour
16.2
110.5
201
230
H02AB02
ATC
dexamethasone; systemic
18.4
108.3
182
170
9052/3-C38.4
ICD-O-3
Epithelioid mesothelioma, malignant of pleura, NOS
+∞
103.6
95
*
GAC01
NOMESCO Finland
Endoscopic biopsy of pleura
389.9
94.0
91
*
A03FA01
ATC
metoclopramide; systemic, rectal
9.3
83.5
216
440
N02AA05
ATC
oxycodone; systemic
8.7
76.7
203
416
A04AA01
ATC
ondansetron; systemic, rectal
15.4
70.5
123
111
GA4YT
NOMESCO Finland
Puncture of pleura with ultrasound guidance
21.4
68.7
104
64
J94.8
ICD-10 Finland
Other specified pleural conditions
30.9
68.4
92
38
GAA10
NOMESCO Finland
Intercostal insertion of pleural drainage tube
25.7
62.2
88
43
WD125
NOMESCO Finland
Demanding cystostatic therapy of methastized malignancy
17.2
55.1
90
66
JN4BD
NOMESCO Finland
Extensive body CT
7.1
49.8
140
280
TGA30
NOMESCO Finland
Thoracocentesis
41.1
48.2
60
17
GD1BD
NOMESCO Finland
Thorax extensive CT-examination
11.5
47.9
94
103
Z51.5
ICD-10 Finland
Palliative care
8.6
46.8
111
170
GAC00
NOMESCO Finland
Biopsy of pleura
94.7
46.0
50
6
GA1AE
NOMESCO Finland
Ultrasound examination of thorax
16.6
42.8
70
50
C38.4
ICD-10 Finland
Malignant neoplasm: Pleura
450.9
41.9
41
*
GD5BD
NOMESCO Finland
Thorax and upper abdomen combined extensive CT examination of
17.5
39.5
63
42
1BA04
NOMESCO Finland
NA
+∞
38.1
36
*
R91
ICD-10 Finland
Abnormal findings on diagnostic imaging of lung
5.6
36.6
122
289
D38.3
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Mediastinum
51.8
35.4
42
9
117
Kela drug reimbursment
Leukaemia and other malignant diseases of the blood and bone marrow, and malignant diseases of the lymphatic tissue
9.5
34.1
73
91
9051/3-C38.4
ICD-O-3
Fibrous mesothelioma, malignant of pleura, NOS
+∞
32.7
31
*
UGC12
NOMESCO Finland
Flexible bronchoscopy
6.1
32.7
98
201
C45.9
ICD-10 Finland
Mesothelioma, unspecified
325.2
30.2
30
*
D38.2
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Pleura
301.0
28.1
28
*
J94.9
ICD-10 Finland
Pleural condition, unspecified
57.6
27.6
32
6
GD1AA
NOMESCO Finland
Thorax X-ray examination
3.2
27.2
246
1319
GAA96
NOMESCO Finland
Other open or percutaneous drainage of pleural cavity
43.3
26.2
32
8
ZX120
NOMESCO Finland
Intravenous
5.1
24.9
86
204
L01CA04
ATC
vinorelbine; systemic
31.4
24.5
32
11
L03AA02
ATC
filgrastim; parenteral
12.2
24.0
44
40
C83.33
ICD-10 Finland
Primary medical lymphoma with large B cells
+∞
23.1
22
*
WF049
NOMESCO Finland
Radiotherapy of metastasis
8.6
22.1
49
64
L03AA13
ATC
pegfilgrastim; parenteral
9.7
21.5
44
50
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
3.4
21.2
123
461
WF004
NOMESCO Finland
Palliative radiotherapy
11.2
21.1
40
39
WD105
NOMESCO Finland
Cystostatic therapy of methastized malignancy
7.6
20.5
49
72
GD1AD
NOMESCO Finland
Thorax CT examination
6.8
20.4
53
88
A04AA02
ATC
granisetron; systemic, transdermal
6.3
20.2
56
101
WZC30
NOMESCO Finland
Teaching
3.9
19.5
89
273
GA4AT
NOMESCO Finland
Cathetrisation of pleural cavity with ultrasound guidance
17.9
19.5
30
18
GAA31
NOMESCO Finland
Thoracoscopy
48.5
19.4
23
5
YG1BD
NOMESCO Finland
Extensive CT examination of thorax for dose design of radiotherapy
11.9
19.1
35
32
9679/3-C38.3
ICD-O-3
Mediastinal large B-cell lymphoma of mediastinum, NOS
+∞
18.9
18
*
WX302
NOMESCO Finland
Thoracal epidural anesthesy
6.2
18.7
52
94
R84
ICPC
Malignant neoplasm bronchus/lung
34.7
18.2
23
7
A04AA55
ATC
palonosetron, combinations; systemic
10.5
18.0
35
36
C81.1
ICD-10 Finland
Nodular sclerosis classical Hodgkin lymphoma
69.8
17.9
20
*
9053/3-C38.4
ICD-O-3
Mesothelioma, biphasic, malignant of pleura, NOS
+∞
17.8
17
*
C83.31
ICD-10 Finland
Diffuse lymphoma with large B cells
14.0
17.7
30
23
C38.3
ICD-10 Finland
Malignant neoplasm: Mediastinum, part unspecified
+∞
16.8
16
*
JN4AD
NOMESCO Finland
Body CT examination
4.3
16.6
65
172
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
3.8
16.5
75
228
J18.9
ICD-10 Finland
Pneumonia, unspecified
2.5
15.9
165
865
9663/3-C38.3
ICD-O-3
Hodgkin lymphoma, nodular sclerosis, NOS, of mediastinum, NOS
+∞
15.7
15
*
A06AH03
ATC
naloxegol; oral
15.6
15.6
25
17
GDA11
NOMESCO Finland
Thoracoscopic biopsy of lung
58.9
14.9
17
*
GD1AT
NOMESCO Finland
Biopsy of the lung with ultrasound guidance
26.2
14.8
20
8
TK800
NOMESCO Finland
Hemodialysis
9.4
14.7
30
34
8000/3-C38.4
ICD-O-3
Neoplasm, malignant of pleura, NOS
+∞
14.7
14
*
GDD20
NOMESCO Finland
Extended pneumonectomy
+∞
14.7
14
*
9680/3-C38.3
ICD-O-3
Diffuse large B-cell lymphoma, NOS, of mediastinum, NOS
+∞
14.7
14
*
C45.1
ICD-10 Finland
Mesothelioma of peritoneum
+∞
14.7
14
*
GD1BA
NOMESCO Finland
Extensive X-ray examination of thorax
10.2
13.9
27
28
GD5AD
NOMESCO Finland
Thorax and upper abdomen combined CT examination of
11.5
13.7
25
23
WW500
NOMESCO Finland
Blood transfusion
5.4
13.6
41
82
A04AD12
ATC
aprepitant; systemic
15.7
13.2
21
14
FB1BD
NOMESCO Finland
Extensive CT examination of arteria pulmonalis
4.1
13.1
52
139
J01MA14
ATC
moxifloxacin; systemic
3.4
13.1
68
229
YG1AD
NOMESCO Finland
CT examination of thorax for dose design of radiotherapy
12.1
13.0
23
20
H02AB06
ATC
prednisolone; systemic
2.2
12.7
217
1403
GD1CT
NOMESCO Finland
Biopsy of the lung with CT guidance
9.2
12.7
26
30
GAC43
NOMESCO Finland
Total decortication of pleura
+∞
12.6
12
*
R06.0
ICD-10 Finland
Dyspnoea
2.4
12.6
128
651
TPH04
NOMESCO Finland
Cathetrisation of vein
2.5
12.5
111
525
WZC00
NOMESCO Finland
Planning of intervention or health care consultation
2.3
12.2
150
831
J86.9
ICD-10 Finland
Pyothorax without fistula
18.8
12.2
18
10
WF003
NOMESCO Finland
Adjuvant radiotherapy
6.8
12.1
30
47
N02AB03
ATC
fentanyl; nasal, sublingual, transdermal
4.4
12.0
44
109
GEA00
NOMESCO Finland
Mediastinoscopy
48.2
11.9
14
*
WD115
NOMESCO Finland
Multiple cystostatic therapy of methastized malignancy
8.5
11.7
25
31
WX408
NOMESCO Finland
General anesthesy, balanced
2.3
11.7
130
684
QBC00
NOMESCO Finland
Removal of foreign body from skin of trunk or subcutaneous tissue
66.9
11.7
13
*
J92.0
ICD-10 Finland
Pleural plaque with presence of asbestos
5.4
11.5
34
67
GA2AT
NOMESCO Finland
Pleural biopsy with ultrasound guidance
+∞
11.5
11
*
GAC30
NOMESCO Finland
Artificial pneumothorax
+∞
11.5
11
*
GDD96
NOMESCO Finland
Other pneumonectomy
+∞
11.5
11
*
GAC97
NOMESCO Finland
Other endoscopic operation on pleura
123.3
11.5
12
*
J01MA12
ATC
levofloxacin; systemic
2.4
11.2
111
550
ZX012
NOMESCO Finland
Radiotherapy with large shaped fields - isocentric therapy
4.4
11.0
40
99
R85
ICPC
Malignant neopl respiratory other
61.6
10.7
12
*
R82
ICPC
Pleurisy/pleural effusion
61.6
10.7
12
*
C45
ICD-10 Finland
Mesothelioma
+∞
10.5
10
*
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
3.7
10.4
46
136
XF400
NOMESCO Finland
ECG with 12 standard connections
2.4
10.4
98
470
Z51.1
ICD-10 Finland
Chemotherapy session for neoplasm
9.5
10.1
20
22
B03BA03
ATC
hydroxocobalamin; parenteral
3.4
10.0
50
163
D70.82
ICD-10 Finland
Drug-induced neutropenia
11.0
9.9
18
17
GAB10
NOMESCO Finland
Antero- or postero-lateral thoracotomy
20.6
9.9
14
7
N03AX16
ATC
pregabalin; oral
2.3
9.8
103
521
WX600
NOMESCO Finland
Single shot through catheter
8.7
9.7
20
24
N02AA01
ATC
morphine; systemic, rectal
7.8
9.5
21
28
WD405
NOMESCO Finland
Simple antiboidy therapy of methastized malignancy
8.4
9.5
20
25
GD2FN
NOMESCO Finland
Lung ventilation distribution isotope examination (radiospirometry)
+∞
9.4
9
*
TPX10
NOMESCO Finland
Implantation of vascular injection port
5.5
9.4
27
52
JN5DR
NOMESCO Finland
PET-CT of upper body metabolism
8.6
9.2
19
23
WD415
NOMESCO Finland
Demanding antibody therapy of methastized malignancy
9.8
8.9
17
18
JN6AD
NOMESCO Finland
CT of torso and neck
9.8
8.9
17
18
Z85.7
ICD-10 Finland
Personal history of other malignant neoplasms of lymphoid, haematopoietic and related tissues
91.9
8.4
9
*
GAC37
NOMESCO Finland
Endoscopic chemical pleurodesis
91.9
8.4
9
*
8000/3-C38.3
ICD-O-3
Neoplasm, malignant of mediastinum, NOS
+∞
8.4
8
*
JN4JR
NOMESCO Finland
Whole body extensive metabolic PET with CT
14.9
8.3
13
9
GA3AT
NOMESCO Finland
Pleural cytology with ultrasound guidance
17.6
8.1
12
7
TPH90
NOMESCO Finland
Removal of fixed intravenous catheter
10.3
8.1
15
15
N02AX02
ATC
tramadol; systemic, rectal
1.8
7.9
178
1207
XX3DW
NOMESCO Finland
Time consuming IT work
2.7
7.8
55
224
R4110
NOMESCO Finland
Physiotherapy
2.0
7.7
111
639
WW200
NOMESCO Finland
Immunization
4.9
7.4
23
49
AA1BD
NOMESCO Finland
Extensive CT of head and brain
4.9
7.4
23
49
C38.8
ICD-10 Finland
Malignant neoplasm: Overlapping lesion of heart, mediastinum and pleura
81.5
7.4
8
*
C96.9
ICD-10 Finland
Malignant neoplasm of lymphoid, haematopoietic and related tissue, unspecified
+∞
7.3
7
*
I87.1
ICD-10 Finland
Compression of vein
+∞
7.3
7
*
Z57.2
ICD-10 Finland
Occupational exposure to dust
30.6
7.2
9
*
Z31.6
ICD-10 Finland
General counselling and advice on procreation
20.4
7.2
10
5
C85.9
ICD-10 Finland
Non-Hodgkin lymphoma, unspecified
20.4
7.2
10
5
WX602
NOMESCO Finland
Repeated or continuing anesthesia shots throug a catheter
3.1
7.2
40
140
B01AB10
ATC
tinzaparin; parenteral
3.2
7.2
37
125
B01AB05
ATC
enoxaparin; parenteral
1.9
7.2
130
812
JN4CD
NOMESCO Finland
Very extensive body CT
3.6
7.0
30
88
CJE20
NOMESCO Finland
Phakoemulsification with implantation of artificial lens in posterior chamber
0.5
6.9
61
1080
ZX090
NOMESCO Finland
Other technic of radiotherapy
4.5
6.8
23
54
D38.1
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Trachea, bronchus and lung
3.8
6.7
27
75
C83.9
ICD-10 Finland
Non-follicular (diffuse) lymphoma, unspecified
22.9
6.7
9
*
C81.9
ICD-10 Finland
Hodgkin lymphoma, unspecified
22.9
6.7
9
*
WZC20
NOMESCO Finland
Multidisciplinary treatment meeting
3.6
6.7
28
81
SPAT1109
SPAT
Analgesia with portable analgesic pump
12.5
6.6
11
9
J38.0
ICD-10 Finland
Paralysis of vocal cords and larynx
8.9
6.6
13
15
1XC02
NOMESCO Finland
NA
10.3
6.6
12
12
A02BC02
ATC
pantoprazole; systemic
1.7
6.5
245
1908
WX404
NOMESCO Finland
Intravenous generell anesthesy
2.1
6.5
72
372
GA2CT
NOMESCO Finland
Pleural biopsy with CT guidance
70.9
6.4
7
*
C38.1
ICD-10 Finland
Malignant neoplasm: Anterior mediastinum
70.9
6.4
7
*
A79
ICPC
Malignancy NOS
6.7
6.4
15
23
C45.7
ICD-10 Finland
Mesothelioma of other sites
+∞
6.3
6
*
GAC96
NOMESCO Finland
Other operation on pleura
+∞
6.3
6
*
GAC20
NOMESCO Finland
Excision or destruction of lesion of pleura
+∞
6.3
6
*
GEB30
NOMESCO Finland
Mediastinotomy and excision of lesion
+∞
6.3
6
*
C38.2
ICD-10 Finland
Malignant neoplasm: Posterior mediastinum
+∞
6.3
6
*
L03AA14
ATC
lipegfilgrastim; parenteral
6.9
6.1
14
21
D07AC01
ATC
betamethasone; topical
0.5
6.0
53
945

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
144
63
33.98
208.01
1.9
1.5
40.1
29.8
g/l
7.21
137
55
133
48
39.79
204.91
2.0
1.3
40200.9
27635.5
e6/l
0.44
107
25
133
48
39.79
204.91
1.9
1.5
—
—
—
0
0
136
53
37.19
204.36
2.0
1.3
1786.3
1856.7
e6/l
0.04
117
35
133
54
35.32
196.79
2.3
1.5
—
—
—
0
0
96
44
27.86
134.03
1.9
1.4
—
—
—
0
0
161
288
8.37
94.09
1.7
1.4
—
—
—
0
0
57
30
21.77
74.01
1.6
1.2
—
—
—
0
0
171
535
4.66
50.79
2.5
2.1
—
—
—
0
0
161
560
4.01
40.04
5.7
3.8
0.8
0.8
mmol/l
4.10
153
525
28
21
14.20
29.94
1.8
1.4
67.5
66.4
%
0.04
22
14
213
1078
2.95
26.54
8.6
5.6
—
—
—
0
0
106
393
3.26
22.40
2.1
4.6
3.7
39.8
ug/l
1.12
85
331
252
1484
2.70
22.17
9.0
6.2
9.6
8.9
%
2.33
247
1381
254
1510
2.68
21.78
9.0
6.0
20.7
25.7
%
8.99
249
1400
258
1578
2.60
20.36
8.2
5.5
0.7
0.6
e9/l
4.95
230
1354
258
1585
2.59
20.06
8.2
5.5
0.0
0.0
e9/l
0.57
232
1374
26
34
8.08
18.88
1.3
1.3
—
—
—
0
0
258
1614
2.51
18.85
8.3
5.7
1.4
1.9
e9/l
5.93
230
1422
199
1115
2.47
18.40
6.7
4.4
—
—
—
0
0
258
1635
2.46
18.01
9.0
5.7
0.2
0.2
e9/l
1.52
232
1436
279
1847
2.47
17.44
19.9
9.3
4.7
4.3
e9/l
1.08
257
1618
31
61
5.40
15.29
2.4
3.0
—
—
—
0
0
204
2862
0.45
14.60
4.5
6.5
40.0
41.0
mmol/mol
0.74
175
2589
90
382
2.72
14.43
1.6
1.5
—
—
—
0
0
148
793
2.33
14.40
13.9
6.5
—
—
—
0
0
28
57
5.19
13.29
1.7
1.2
8.4
8.1
u/l
0.05
23
46
229
3035
0.47
12.90
3.4
5.2
2.7
2.5
mmol/l
1.45
187
2711
229
1520
2.09
12.53
6.6
11.3
1.1
1.4
inr
3.95
42
414
218
2927
0.48
12.46
3.3
4.6
1.4
1.4
mmol/l
0.27
183
2608
25
49
5.36
12.36
8.5
6.4
10.6
11.8
mg/l
0.69
25
43
18
26
7.18
11.94
2.1
1.3
—
—
—
0
0
16
21
7.88
11.49
2.3
2.0
11.7
11.2
%
—
6
12
225
2958
0.49
11.39
3.2
4.7
4.5
4.4
mmol/l
1.05
191
2666
243
1694
2.01
11.12
8.7
7.7
1.2
1.2
mmol/l
0.01
216
1409
20
35
5.95
11.11
2.4
1.7
1.0
1.1
e9/l
0.14
12
14
220
1489
1.98
10.88
7.2
5.2
31.1
34.7
g/l
12.45
208
1391
163
1001
2.02
10.57
5.3
4.2
7.4
7.4
ph
0.59
25
198
11
10
11.26
10.20
3.2
1.2
—
—
—
0
0
140
824
2.04
10.15
3.0
2.7
—
—
—
0
0
225
1561
1.93
10.09
8.4
7.1
1.2
1.2
mmol/l
0.12
219
1389
52
199
2.84
10.02
1.3
1.5
—
—
—
0
0
120
675
2.08
9.79
6.6
3.3
2.5
2.4
mmol/l
7.98
108
594
186
1231
1.91
9.44
2.9
2.3
—
—
—
0
0
219
2835
0.53
9.21
3.1
4.2
1.2
1.2
mmol/l
1.14
179
2512
52
211
2.67
8.95
5.0
4.9
—
—
—
0
0
166
1086
1.86
8.53
3.4
2.7
—
—
—
0
0
58
1110
0.45
7.67
2.9
4.1
1.3
9.6
mg/mmol
9.11
30
709
56
1077
0.45
7.46
2.1
3.2
9.0
7.4
mmol/l
1.67
44
867
169
1150
1.78
7.39
7.8
3.5
2.4
2.3
mmol/l
0.69
152
991
54
1045
0.45
7.28
2.1
3.3
13.4
223.2
mg/l
1.60
31
690
43
177
2.59
7.19
5.6
5.6
26.1
25.0
mmol/l
1.34
43
169
10
7
14.59
6.42
1.2
1.0
26.0
18.5
g/l
—
10
7
10
8
12.76
6.11
1.9
1.6
—
—
—
0
0
248
2980
0.60
6.07
4.1
5.0
6.0
6.1
mmol/l
0.23
211
2647
23
75
3.18
5.86
2.9
4.3
—
—
—
0
0
105
1548
0.57
5.71
3.2
3.8
0.0
0.0
estimate
0.00
27
307
107
1568
0.58
5.68
3.2
3.9
0.0
0.0
estimate
0.00
28
293
106
1546
0.58
5.46
4.5
5.2
0.0
0.0
estimate
0.00
27
308
130
1798
0.60
5.42
4.2
5.7
2.4
3.5
ug/l
1.24
106
1562
110
737
1.66
4.75
2.4
3.0
555.1
578.2
mosm/kgh2o
0.53
98
622
107
717
1.66
4.60
5.4
3.8
157.0
300.5
ng/l
0.69
93
591
8
8
10.16
4.53
1.9
1.1
9.4
9.0
mu/l
—
8
8
71
427
1.79
4.50
1.3
1.3
—
—
—
0
0
183
1406
1.53
4.35
15.2
10.1
0.0
0.0
e9/l
0.17
142
1145
197
1540
1.52
4.30
4.8
4.5
—
—
—
0
0
23
91
2.61
4.20
1.7
2.1
8.6
14.3
mg/l
2.83
23
85
101
684
1.62
4.13
2.2
1.7
1.6
1.5
mg/l
0.17
81
538
55
314
1.86
4.11
1.5
1.6
—
—
—
0
0
10
23
4.43
4.11
1.5
1.2
—
—
—
0
0
12
355
0.32
4.10
1.1
1.3
—
—
—
0
0
72
449
1.73
4.02
1.7
1.8
—
—
—
0
0
106
1460
0.64
3.95
1.5
2.1
95.8
92.2
pmol/l
0.27
60
779
10
24
4.24
3.91
1.7
1.1
—
—
—
0
0
58
344
1.79
3.84
1.4
1.3
373.3
336.0
titre
0.13
15
70
73
465
1.69
3.77
6.8
9.0
1.7
1.3
mmol/l
0.61
63
358
25
109
2.37
3.76
5.0
3.8
—
—
—
0
0
304
3380
0.65
3.76
49.5
25.4
124.2
134.4
g/l
19.88
297
3307
304
3379
0.65
3.74
48.9
25.3
7.8
6.9
e9/l
2.47
293
3258
10
25
4.07
3.72
3.0
1.6
463.8
708.9
e6/l
—
5
14
304
3378
0.65
3.71
48.7
25.3
4.3
4.4
e12/l
7.61
293
3256
304
3378
0.65
3.71
48.6
25.2
29.5
30.5
pg
14.02
296
3307
304
3377
0.65
3.69
48.6
25.2
90.4
91.6
fl
4.35
296
3307
304
3375
0.66
3.65
48.7
25.3
288.5
236.2
e9/l
17.11
293
3267
241
2007
1.46
3.62
8.0
5.8
6.5
6.8
mmol/l
2.17
234
1887
16
57
2.88
3.56
4.2
3.0
4.4
4.8
e9/l
0.31
16
57
238
2764
0.69
3.56
5.6
4.3
2.1
2.0
mu/l
0.36
209
2426
129
955
1.50
3.51
2.7
3.3
—
—
—
0
0
134
1007
1.48
3.37
2.6
3.3
0.8
0.6
e6/l
0.34
107
772
16
59
2.78
3.36
5.2
3.6
63.4
60.6
%
0.29
16
59
47
273
1.81
3.34
6.0
4.1
1.8
1.0
%
0.84
28
93
44
253
1.82
3.24
6.3
4.2
0.2
0.1
%
0.39
27
83
58
876
0.61
3.11
2.3
3.1
—
—
—
0
0
59
886
0.61
3.08
3.4
4.1
0.0
0.0
estimate
0.00
25
291
44
258
1.79
3.05
1.4
1.5
—
—
—
0
0
286
2502
1.43
3.03
16.5
8.0
86.2
80.1
u/l
1.54
281
2329
12
304
0.38
3.00
2.3
1.6
—
—
—
0
0
142
1101
1.43
2.98
2.7
3.5
21.2
156.2
e6/l
1.60
115
870
41
237
1.81
2.98
5.3
4.1
1.0
0.4
%
0.88
20
68
71
480
1.57
2.89
7.4
6.2
1.0
1.0
mmol/l
0.07
65
438
13
47
2.82
2.84
5.6
3.8
—
—
—
0
0
58
376
1.63
2.81
1.6
1.6
—
—
—
0
0
30
161
1.93
2.74
1.1
1.3
—
—
—
0
0
18
79
2.33
2.71
2.5
2.4
13.9
15.2
%
—
7
35
54
347
1.64
2.71
6.0
4.7
—
—
—
0
0
21
99
2.18
2.69
4.4
4.9
7.4
7.4
ph
1.69
21
82
47
722
0.61
2.68
3.0
4.0
—
—
—
0
0
64
915
0.65
2.66
1.3
1.6
23.2
19.3
nmol/l
1.06
57
756
17
74
2.35
2.61
1.4
1.2
—
—
—
0
0
9
223
0.39
2.50
2.0
3.0
—
—
—
0
0
9
26
3.51
2.49
2.6
1.2
—
—
—
0
0
53
779
0.64
2.49
1.4
1.8
523.2
9091341.2
pmol/l
0.50
38
627
290
3185
0.72
2.48
29.5
16.5
—
—
—
0
0
297
3245
0.72
2.41
19.8
11.2
24.5
25.0
u/l
0.20
289
3094
9
27
3.38
2.40
6.8
3.3
—
—
—
0
0
12
46
2.66
2.38
1.3
1.2
—
—
—
0
0
108
828
1.41
2.36
1.5
1.4
—
—
—
0
0
13
53
2.50
2.30
2.9
1.8
151.2
12375.9
u/l
—
8
12
14
60
2.38
2.24
1.4
3.1
—
—
—
0
0
38
235
1.68
2.23
6.0
4.3
0.1
0.2
%
0.11
23
70
12
48
2.54
2.20
2.3
1.2
—
—
—
0
0
298
3240
0.73
2.19
34.9
21.1
4.0
4.0
mmol/l
0.13
289
3144
298
3237
0.74
2.15
34.7
20.9
138.4
139.6
mmol/l
9.90
290
3139
86
644
1.42
2.13
6.2
5.0
—
—
—
0
0
61
844
0.68
2.12
3.2
3.5
—
—
—
0
0
11
43
2.60
2.11
1.3
1.8
—
—
—
0
0
11
43
2.60
2.11
1.3
1.8
—
—
—
0
0
11
43
2.60
2.11
1.3
1.8
—
—
—
0
0
11
43
2.60
2.11
1.3
1.8
—
—
—
0
0
20
103
1.99
2.09
2.9
2.9
25.1
24.9
mmol/l
0.08
14
82
0
56
0.00
2.08
0.0
2.9
—
—
—
0
0
6
15
4.04
2.04
1.0
1.2
—
—
—
0
0
47
315
1.55
2.01
11.1
10.5
—
—
—
0
0
79
1030
0.71
1.96
2.7
3.3
0.9
0.8
ug/l
0.15
57
731
34
212
1.66
1.95
11.7
14.0
—
—
—
0
0
9
33
2.76
1.94
1.7
2.4
28.7
36.4
u/ml
—
9
33
79
1026
0.72
1.92
2.5
3.3
—
—
—
0
0
40
589
0.65
1.89
1.2
1.2
1.2
1.5
u/ml
—
6
146
15
72
2.12
1.88
2.2
2.6
—
—
—
0
0
5
12
4.20
1.83
1.4
2.6
—
—
—
0
0
12
53
2.30
1.82
1.4
1.5
—
—
—
0
0
6
18
3.37
1.75
1.5
1.2
2.1
1.8
mmol/l
—
6
18
7
24
2.95
1.73
1.1
1.2
—
—
—
0
0
15
76
2.01
1.66
1.7
2.2
116.1
124.1
g/l
—
8
51
57
763
0.71
1.64
1.7
1.8
1219.0
1167.0
nmol/l
0.12
37
573
20
335
0.58
1.62
1.8
2.4
0.2
0.2
g/l
1.31
20
307
5
14
3.60
1.62
1.2
3.1
925.6
1064.4
u/ml
—
5
14
10
43
2.36
1.61
6.5
3.7
—
—
—
0
0
126
1045
1.29
1.59
3.6
2.6
53.4
55.7
u/l
0.39
119
963
147
1249
1.27
1.53
3.2
4.0
134.2
75.6
e6/l
0.33
117
927
196
2196
0.80
1.48
5.2
3.4
14.9
14.9
pmol/l
0.01
179
1919
34
229
1.53
1.47
1.2
1.4
—
—
—
0
0
55
408
1.40
1.46
1.6
1.7
—
—
—
0
0
11
52
2.14
1.45
2.7
1.8
89.2
89.6
%
0.12
11
52
12
59
2.06
1.45
2.3
1.2
4.4
3.8
mmol/l
0.44
12
54
223
2457
0.81
1.41
43.3
23.1
327.3
332.2
g/l
11.63
218
2439
5
120
0.41
1.39
2.6
1.8
—
—
—
0
0
63
484
1.35
1.36
8.4
8.0
102.9
104.4
mmol/l
1.71
63
473
6
24
2.52
1.31
1.2
1.2
—
—
—
0
0
105
872
1.27
1.30
3.9
3.1
286.9
8847.7
umol/l
4.48
93
737
142
1222
1.24
1.30
3.1
3.3
1100.0
1929.3
ng/l
3.60
129
1068
95
780
1.28
1.29
2.2
2.7
4.0
4.0
e6/l
0.02
87
685
12
64
1.90
1.19
2.4
1.2
47.7
14.2
e6/l
—
7
51
12
64
1.90
1.19
2.3
1.3
30.7
1867.8
e6/l
—
7
52
16
96
1.69
1.11
1.0
1.2
—
—
—
0
0
29
202
1.47
1.11
3.2
3.0
6.3
4.0
e9/l
1.59
19
148
21
136
1.57
1.10
1.1
1.2
33.4
138.5
iu/ml
—
5
50
15
91
1.67
1.02
1.1
1.2
—
2.6
—
0
7
0
29
0.00
0.98
0.0
1.1
—
279.9
—
0
19
73
603
1.25
0.96
1.8
2.6
9.7
12.4
umol/l
3.03
67
555
17
256
0.65
0.95
2.8
4.2
94.9
92.0
ng/l
0.02
11
222
20
291
0.67
0.95
1.6
2.2
94.2
147.5
ug/g
1.38
15
227
6
29
2.08
0.89
2.7
2.5
—
—
—
0
0
38
291
1.34
0.88
2.2
5.7
—
—
—
0
0
6
30
2.01
0.87
1.3
1.1
—
—
—
0
0
230
2464
0.86
0.86
43.2
21.2
14.5
13.9
%
8.16
225
2415
13
201
0.64
0.83
1.1
1.2
—
—
—
0
0
43
341
1.29
0.80
2.0
3.1
180.3
245.8
ng/l
0.83
37
310
0
24
0.00
0.79
0.0
1.2
—
—
—
0
0
0
25
0.00
0.79
0.0
1.0
—
260.6
—
0
13
14
210
0.66
0.79
2.0
2.8
—
—
—
0
0
5
97
0.51
0.79
23.2
10.3
—
—
—
0
0
62
517
1.23
0.77
1.8
2.6
19.5
21.9
%
0.72
57
450
44
355
1.27
0.73
2.5
2.6
6.6
8.2
ug/l
0.46
39
310
23
308
0.73
0.72
1.9
3.6
—
—
—
0
0
7
40
1.76
0.71
1.6
1.1
—
—
—
0
0
7
41
1.72
0.70
3.6
2.7
4.8
7.5
nmol/l
—
7
41
120
1329
0.86
0.66
2.5
2.8
443.0
159.7
ug/l
2.78
111
1202
51
427
1.22
0.63
1.2
1.3
19.6
41.3
iu/ml
—
10
127
9
140
0.64
0.61
1.3
1.4
—
—
—
0
0
0
23
0.00
0.58
0.0
1.3
—
—
—
0
0
6
36
1.68
0.57
1.0
1.2
—
—
—
0
0
6
100
0.59
0.52
2.0
1.4
—
—
—
0
0
35
416
0.83
0.46
1.1
1.3
—
—
—
0
0
8
120
0.66
0.46
1.8
3.6
42.7
128.0
mg/l
—
8
96
8
120
0.66
0.46
1.8
3.6
27.3
36.0
mg/l
—
8
99
113
1037
1.12
0.46
2.7
2.2
280.6
317.7
u/l
0.17
113
969
54
475
1.16
0.41
2.6
2.4
1.7
1.7
%
0.04
48
423
0
15
0.00
0.41
0.0
4.3
—
—
—
0
0
0
15
0.00
0.41
0.0
11.1
—
782.3
—
0
15
0
15
0.00
0.41
0.0
1.1
—
—
—
0
0
0
15
0.00
0.41
0.0
16.5
—
1328.8
—
0
15
46
400
1.17
0.41
1.2
1.3
37.9
13.6
u/ml
—
10
143
0
17
0.00
0.40
0.0
1.2
—
140.8
—
0
17
0
17
0.00
0.40
0.0
3.6
—
31.6
—
0
11
0
17
0.00
0.40
0.0
1.4
—
—
—
0
0
8
60
1.34
0.40
3.0
3.1
—
—
—
0
0
302
3105
0.91
0.39
38.8
17.4
44.3
27.7
mg/l
8.67
285
2534
30
253
1.20
0.38
1.2
2.6
—
—
—
0
0
11
146
0.75
0.36
1.0
1.2
—
—
—
0
0
12
157
0.76
0.36
1.2
1.3
—
—
—
0
0
12
157
0.76
0.36
4.2
4.5
—
—
—
0
0
5
78
0.64
0.36
1.0
1.2
—
—
—
0
0
10
73
1.38
0.35
2.1
1.6
—
—
—
0
0
41
359
1.16
0.34
6.9
4.5
6.4
5.7
kpa
1.78
41
344
259
2674
0.92
0.34
36.1
19.0
38.4
39.0
%
0.55
183
1680
6
45
1.34
0.34
2.2
8.7
6.3
6.7
mmol/l
—
6
36
6
46
1.31
0.33
1.2
1.0
—
—
—
0
0
6
46
1.31
0.33
2.0
1.8
29.8
33.2
pg
—
6
46
11
84
1.32
0.30
1.2
1.5
—
—
—
0
0
60
546
1.12
0.30
17.2
30.7
1.2
1.4
inr
—
6
74
10
130
0.76
0.30
2.7
3.5
3.8
4.0
mmol/l
—
10
120
42
374
1.14
0.29
6.7
4.4
—
—
—
0
0
7
57
1.23
0.29
1.0
1.1
—
—
—
0
0
14
172
0.81
0.28
2.3
2.5
—
—
—
0
0
148
1412
1.07
0.27
4.2
4.2
37.8
47.1
ng/l
0.31
120
1090
9
73
1.24
0.25
1.3
1.1
—
—
—
0
0
16
191
0.83
0.25
4.5
4.0
25.6
24.8
mmol/l
0.58
16
183
20
233
0.85
0.24
6.2
4.0
122.3
125.7
g/l
0.29
20
226
5
38
1.32
0.23
1.0
1.0
—
—
—
0
0
32
286
1.13
0.22
3.2
3.6
—
—
—
0
0
13
107
1.22
0.22
3.8
5.4
—
—
—
0
0
0
10
0.00
0.21
0.0
8.5
—
0.6
—
0
10
0
10
0.00
0.21
0.0
1.2
—
—
—
0
0
0
10
0.00
0.21
0.0
1.2
—
—
—
0
0
15
177
0.84
0.21
3.9
4.3
—
—
—
0
0
0
12
0.00
0.21
0.0
1.0
—
37.9
—
0
7
11
89
1.24
0.21
13.3
3.7
1.1
1.8
mg/l
2.77
11
80
0
13
0.00
0.21
0.0
1.0
—
—
—
0
0
0
13
0.00
0.21
0.0
1.1
—
—
—
0
0
13
155
0.83
0.20
1.5
1.2
154.8
157.2
u/ml
0.01
13
138
0
14
0.00
0.20
0.0
4.6
—
—
—
0
0
0
14
0.00
0.20
0.0
1.9
—
0.8
—
0
14
9
114
0.79
0.20
1.3
1.1
—
—
—
0
0
38
350
1.09
0.17
2.8
2.7
59.3
66.5
e9/l
0.61
26
276
18
160
1.13
0.14
1.6
1.4
—
—
—
0
0
28
303
0.92
0.12
9.2
3.7
5.4
4.5
kpa
0.69
28
289
18
198
0.91
0.11
1.3
1.6
—
—
—
0
0
5
46
1.09
0.09
1.0
1.3
—
—
—
0
0
18
165
1.09
0.09
3.7
7.1
1.8
1.6
%
0.25
18
154
6
56
1.07
0.08
1.0
1.4
—
—
—
0
0
5
60
0.83
0.08
1.0
1.1
24.8
47.8
u/l
—
5
50
57
549
1.04
0.08
1.5
1.4
2.0
2.7
g/l
1.71
39
312
7
82
0.85
0.07
1.9
3.6
—
—
—
0
0
8
94
0.85
0.06
3.4
10.7
103.6
105.4
mmol/l
—
8
85
8
94
0.85
0.06
3.4
10.7
10.6
11.5
mmol/l
—
8
85
93
950
0.97
0.06
1.8
2.1
3.7
3.1
mg/l
1.38
78
810
10
90
1.11
0.05
1.4
1.3
—
—
—
0
0
236
2339
1.02
0.05
4.7
4.1
23.0
13.7
mm/h
5.91
227
2103
219
2209
0.98
0.05
3.9
4.4
—
—
—
0
0
223
2248
0.98
0.04
4.0
4.4
—
—
—
0
0
16
166
0.96
0.00
3.8
7.2
0.8
0.9
%
0.28
16
155
107
1074
1.00
0.00
4.5
4.5
—
—
—
0
0
0
5
0.00
0.00
0.0
1.8
—
—
—
0
0
0
5
0.00
0.00
0.0
2.6
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
5.6
—
5.7
—
0
5
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
6
63
0.95
0.00
9.5
3.3
73.8
60.9
%
—
6
63
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.4
—
43.3
—
0
5
0
5
0.00
0.00
0.0
1.0
—
169.8
—
0
5
0
7
0.00
0.00
0.0
4.9
—
—
—
0
0
0
7
0.00
0.00
0.0
1.9
—
—
—
0
0
6
62
0.97
0.00
1.3
1.5
—
—
—
0
0
0
7
0.00
0.00
0.0
1.6
—
—
—
0
0
7
73
0.96
0.00
8.3
3.8
—
—
—
0
0
0
7
0.00
0.00
0.0
1.3
—
—
—
0
0
0
9
0.00
0.00
0.0
1.2
—
—
—
0
0
0
7
0.00
0.00
0.0
3.7
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
8
81
0.99
0.00
1.0
1.1
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
0
7
0.00
0.00
0.0
3.3
—
3351.1
—
0
7

Mortality – FinRegistry

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

Relationships between endpoints

Index endpoint: C3_HEART_MEDIASTINUM_PLEURA – Malignant neoplasm of heart, mediastinum and pleura

GWS hits: -

This endpoint is excluded from FinRegistry analyses (omitted endpoint).