This is a non-core endpoint: only basic statistics are computed.
See its core counterpart C3_HEART_MEDIASTINUM_PLEURA_EXALLC for full statistics.
Malignant neoplasm of heart, mediastinum and pleura
C3_HEART_MEDIASTINUM_PLEURA
Heart neoplasm: Tumors in any part of the heart. They include primary cardiac tumors and metastatic tumors to the heart. Their interference with normal cardiac functions can cause a wide variety of symptoms including HEART FAILURE; CARDIAC ARRHYTHMIAS; or EMBOLISM.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
427 |
4. Check minimum number of eventsNone |
427 |
5. Include endpointsNone |
427 |
6. Filter based on genotype QC (FinnGen only) |
427 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF9
Similar endpoints
↥List of similar endpoints to
Malignant neoplasm of heart, mediastinum and pleura
based on the number of shared cases.
Similar with more cases:
- Malignant neoplasm of heart, mediastinum and pleura, excluding all cancers (controls excluding all cancers)
- Malignant neoplasm of respiratory system and intrathoracic organs
- Malignant neoplasm of respiratory system and intrathoracic organs, excluding all cancers (controls excluding all cancers)
- Malignant neoplasm
- Any event in cancer register
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
This endpoint is excluded from FinRegistry analyses (omitted endpoint).
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 427 | 112 | 315 |
| Unadjusted period prevalence (%) | 0.11 | 0.04 | 0.14 |
| Median age at first event (years) | 69.61 | 62.71 | 72.06 |
-FinnGen-
Age distribution of first events
-FinnGen-
Year distribution of first events
-FinnGen-
Cumulative Incidence Function
Not a core endpoint, no data to show.
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 410
- Matched controls
- 4098
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
C45.0
ICD-10 Finland
Mesothelioma of pleura
7931.8
305.0
255
*
J90
ICD-10 Finland
Pleural effusion, not elsewhere classified
44.9
169.4
213
96
9050/3-C38.4
ICD-O-3
Mesothelioma, malignant of pleura, NOS
+∞
135.1
122
*
130
Kela drug reimbursment
Malignant tumour
16.2
110.5
201
230
H02AB02
ATC
dexamethasone; systemic
18.4
108.3
182
170
9052/3-C38.4
ICD-O-3
Epithelioid mesothelioma, malignant of pleura, NOS
+∞
103.6
95
*
GAC01
NOMESCO Finland
Endoscopic biopsy of pleura
389.9
94.0
91
*
A03FA01
ATC
metoclopramide; systemic, rectal
9.3
83.5
216
440
N02AA05
ATC
oxycodone; systemic
8.7
76.7
203
416
A04AA01
ATC
ondansetron; systemic, rectal
15.4
70.5
123
111
GA4YT
NOMESCO Finland
Puncture of pleura with ultrasound guidance
21.4
68.7
104
64
J94.8
ICD-10 Finland
Other specified pleural conditions
30.9
68.4
92
38
GAA10
NOMESCO Finland
Intercostal insertion of pleural drainage tube
25.7
62.2
88
43
WD125
NOMESCO Finland
Demanding cystostatic therapy of methastized malignancy
17.2
55.1
90
66
JN4BD
NOMESCO Finland
Extensive body CT
7.1
49.8
140
280
TGA30
NOMESCO Finland
Thoracocentesis
41.1
48.2
60
17
GD1BD
NOMESCO Finland
Thorax extensive CT-examination
11.5
47.9
94
103
Z51.5
ICD-10 Finland
Palliative care
8.6
46.8
111
170
GAC00
NOMESCO Finland
Biopsy of pleura
94.7
46.0
50
6
GA1AE
NOMESCO Finland
Ultrasound examination of thorax
16.6
42.8
70
50
C38.4
ICD-10 Finland
Malignant neoplasm: Pleura
450.9
41.9
41
*
GD5BD
NOMESCO Finland
Thorax and upper abdomen combined extensive CT examination of
17.5
39.5
63
42
1BA04
NOMESCO Finland
NA
+∞
38.1
36
*
R91
ICD-10 Finland
Abnormal findings on diagnostic imaging of lung
5.6
36.6
122
289
D38.3
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Mediastinum
51.8
35.4
42
9
117
Kela drug reimbursment
Leukaemia and other malignant diseases of the blood and bone marrow, and malignant diseases of the lymphatic tissue
9.5
34.1
73
91
9051/3-C38.4
ICD-O-3
Fibrous mesothelioma, malignant of pleura, NOS
+∞
32.7
31
*
UGC12
NOMESCO Finland
Flexible bronchoscopy
6.1
32.7
98
201
C45.9
ICD-10 Finland
Mesothelioma, unspecified
325.2
30.2
30
*
D38.2
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Pleura
301.0
28.1
28
*
J94.9
ICD-10 Finland
Pleural condition, unspecified
57.6
27.6
32
6
GD1AA
NOMESCO Finland
Thorax X-ray examination
3.2
27.2
246
1319
GAA96
NOMESCO Finland
Other open or percutaneous drainage of pleural cavity
43.3
26.2
32
8
ZX120
NOMESCO Finland
Intravenous
5.1
24.9
86
204
L01CA04
ATC
vinorelbine; systemic
31.4
24.5
32
11
L03AA02
ATC
filgrastim; parenteral
12.2
24.0
44
40
C83.33
ICD-10 Finland
Primary medical lymphoma with large B cells
+∞
23.1
22
*
WF049
NOMESCO Finland
Radiotherapy of metastasis
8.6
22.1
49
64
L03AA13
ATC
pegfilgrastim; parenteral
9.7
21.5
44
50
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
3.4
21.2
123
461
WF004
NOMESCO Finland
Palliative radiotherapy
11.2
21.1
40
39
WD105
NOMESCO Finland
Cystostatic therapy of methastized malignancy
7.6
20.5
49
72
GD1AD
NOMESCO Finland
Thorax CT examination
6.8
20.4
53
88
A04AA02
ATC
granisetron; systemic, transdermal
6.3
20.2
56
101
WZC30
NOMESCO Finland
Teaching
3.9
19.5
89
273
GA4AT
NOMESCO Finland
Cathetrisation of pleural cavity with ultrasound guidance
17.9
19.5
30
18
GAA31
NOMESCO Finland
Thoracoscopy
48.5
19.4
23
5
YG1BD
NOMESCO Finland
Extensive CT examination of thorax for dose design of radiotherapy
11.9
19.1
35
32
9679/3-C38.3
ICD-O-3
Mediastinal large B-cell lymphoma of mediastinum, NOS
+∞
18.9
18
*
WX302
NOMESCO Finland
Thoracal epidural anesthesy
6.2
18.7
52
94
R84
ICPC
Malignant neoplasm bronchus/lung
34.7
18.2
23
7
A04AA55
ATC
palonosetron, combinations; systemic
10.5
18.0
35
36
C81.1
ICD-10 Finland
Nodular sclerosis classical Hodgkin lymphoma
69.8
17.9
20
*
9053/3-C38.4
ICD-O-3
Mesothelioma, biphasic, malignant of pleura, NOS
+∞
17.8
17
*
C83.31
ICD-10 Finland
Diffuse lymphoma with large B cells
14.0
17.7
30
23
C38.3
ICD-10 Finland
Malignant neoplasm: Mediastinum, part unspecified
+∞
16.8
16
*
JN4AD
NOMESCO Finland
Body CT examination
4.3
16.6
65
172
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
3.8
16.5
75
228
J18.9
ICD-10 Finland
Pneumonia, unspecified
2.5
15.9
165
865
9663/3-C38.3
ICD-O-3
Hodgkin lymphoma, nodular sclerosis, NOS, of mediastinum, NOS
+∞
15.7
15
*
A06AH03
ATC
naloxegol; oral
15.6
15.6
25
17
GDA11
NOMESCO Finland
Thoracoscopic biopsy of lung
58.9
14.9
17
*
GD1AT
NOMESCO Finland
Biopsy of the lung with ultrasound guidance
26.2
14.8
20
8
TK800
NOMESCO Finland
Hemodialysis
9.4
14.7
30
34
8000/3-C38.4
ICD-O-3
Neoplasm, malignant of pleura, NOS
+∞
14.7
14
*
GDD20
NOMESCO Finland
Extended pneumonectomy
+∞
14.7
14
*
9680/3-C38.3
ICD-O-3
Diffuse large B-cell lymphoma, NOS, of mediastinum, NOS
+∞
14.7
14
*
C45.1
ICD-10 Finland
Mesothelioma of peritoneum
+∞
14.7
14
*
GD1BA
NOMESCO Finland
Extensive X-ray examination of thorax
10.2
13.9
27
28
GD5AD
NOMESCO Finland
Thorax and upper abdomen combined CT examination of
11.5
13.7
25
23
WW500
NOMESCO Finland
Blood transfusion
5.4
13.6
41
82
A04AD12
ATC
aprepitant; systemic
15.7
13.2
21
14
FB1BD
NOMESCO Finland
Extensive CT examination of arteria pulmonalis
4.1
13.1
52
139
J01MA14
ATC
moxifloxacin; systemic
3.4
13.1
68
229
YG1AD
NOMESCO Finland
CT examination of thorax for dose design of radiotherapy
12.1
13.0
23
20
H02AB06
ATC
prednisolone; systemic
2.2
12.7
217
1403
GD1CT
NOMESCO Finland
Biopsy of the lung with CT guidance
9.2
12.7
26
30
GAC43
NOMESCO Finland
Total decortication of pleura
+∞
12.6
12
*
R06.0
ICD-10 Finland
Dyspnoea
2.4
12.6
128
651
TPH04
NOMESCO Finland
Cathetrisation of vein
2.5
12.5
111
525
WZC00
NOMESCO Finland
Planning of intervention or health care consultation
2.3
12.2
150
831
J86.9
ICD-10 Finland
Pyothorax without fistula
18.8
12.2
18
10
WF003
NOMESCO Finland
Adjuvant radiotherapy
6.8
12.1
30
47
N02AB03
ATC
fentanyl; nasal, sublingual, transdermal
4.4
12.0
44
109
GEA00
NOMESCO Finland
Mediastinoscopy
48.2
11.9
14
*
WD115
NOMESCO Finland
Multiple cystostatic therapy of methastized malignancy
8.5
11.7
25
31
WX408
NOMESCO Finland
General anesthesy, balanced
2.3
11.7
130
684
QBC00
NOMESCO Finland
Removal of foreign body from skin of trunk or subcutaneous tissue
66.9
11.7
13
*
J92.0
ICD-10 Finland
Pleural plaque with presence of asbestos
5.4
11.5
34
67
GA2AT
NOMESCO Finland
Pleural biopsy with ultrasound guidance
+∞
11.5
11
*
GDD96
NOMESCO Finland
Other pneumonectomy
+∞
11.5
11
*
GAC30
NOMESCO Finland
Artificial pneumothorax
+∞
11.5
11
*
GAC97
NOMESCO Finland
Other endoscopic operation on pleura
123.3
11.5
12
*
Z2446
NOMESCO Finland
Social worker
4.2
11.4
44
115
J01MA12
ATC
levofloxacin; systemic
2.4
11.2
111
550
ZX012
NOMESCO Finland
Radiotherapy with large shaped fields - isocentric therapy
4.4
11.0
40
99
R82
ICPC
Pleurisy/pleural effusion
61.6
10.7
12
*
R85
ICPC
Malignant neopl respiratory other
61.6
10.7
12
*
C45
ICD-10 Finland
Mesothelioma
+∞
10.5
10
*
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
3.7
10.4
46
136
XF400
NOMESCO Finland
ECG with 12 standard connections
2.4
10.4
98
470
Z51.1
ICD-10 Finland
Chemotherapy session for neoplasm
9.5
10.1
20
22
B03BA03
ATC
hydroxocobalamin; parenteral
3.4
10.0
50
163
D70.82
ICD-10 Finland
Drug-induced neutropenia
11.0
9.9
18
17
GAB10
NOMESCO Finland
Antero- or postero-lateral thoracotomy
20.6
9.9
14
7
N03AX16
ATC
pregabalin; oral
2.3
9.8
103
521
WX600
NOMESCO Finland
Single shot through catheter
8.7
9.7
20
24
N02AA01
ATC
morphine; systemic, rectal
7.8
9.5
21
28
WD405
NOMESCO Finland
Simple antiboidy therapy of methastized malignancy
8.4
9.5
20
25
GD2FN
NOMESCO Finland
Lung ventilation distribution isotope examination (radiospirometry)
+∞
9.4
9
*
TPX10
NOMESCO Finland
Implantation of vascular injection port
5.5
9.4
27
52
ZXD10
NOMESCO Finland
Scheduled procedure
2.0
9.2
164
1037
JN5DR
NOMESCO Finland
PET-CT of upper body metabolism
8.6
9.2
19
23
JN6AD
NOMESCO Finland
CT of torso and neck
9.8
8.9
17
18
WD415
NOMESCO Finland
Demanding antibody therapy of methastized malignancy
9.8
8.9
17
18
GAC37
NOMESCO Finland
Endoscopic chemical pleurodesis
91.9
8.4
9
*
Z85.7
ICD-10 Finland
Personal history of other malignant neoplasms of lymphoid, haematopoietic and related tissues
91.9
8.4
9
*
8000/3-C38.3
ICD-O-3
Neoplasm, malignant of mediastinum, NOS
+∞
8.4
8
*
JN4JR
NOMESCO Finland
Whole body extensive metabolic PET with CT
14.9
8.3
13
9
ZXE10
NOMESCO Finland
More than one and less than three hours
1.9
8.2
153
973
GA3AT
NOMESCO Finland
Pleural cytology with ultrasound guidance
17.6
8.1
12
7
TPH90
NOMESCO Finland
Removal of fixed intravenous catheter
10.3
8.1
15
15
N02AX02
ATC
tramadol; systemic, rectal
1.8
7.9
178
1207
ZXE00
NOMESCO Finland
One hour or less
1.9
7.8
159
1039
XX3DW
NOMESCO Finland
Time consuming IT work
2.7
7.8
55
224
R4110
NOMESCO Finland
Physiotherapy
2.0
7.7
111
639
AA1BD
NOMESCO Finland
Extensive CT of head and brain
4.9
7.4
23
49
WW200
NOMESCO Finland
Immunization
4.9
7.4
23
49
C38.8
ICD-10 Finland
Malignant neoplasm: Overlapping lesion of heart, mediastinum and pleura
81.5
7.4
8
*
I87.1
ICD-10 Finland
Compression of vein
+∞
7.3
7
*
C96.9
ICD-10 Finland
Malignant neoplasm of lymphoid, haematopoietic and related tissue, unspecified
+∞
7.3
7
*
Z57.2
ICD-10 Finland
Occupational exposure to dust
30.6
7.2
9
*
C85.9
ICD-10 Finland
Non-Hodgkin lymphoma, unspecified
20.4
7.2
10
5
Z31.6
ICD-10 Finland
General counselling and advice on procreation
20.4
7.2
10
5
WX602
NOMESCO Finland
Repeated or continuing anesthesia shots throug a catheter
3.1
7.2
40
140
B01AB10
ATC
tinzaparin; parenteral
3.2
7.2
37
125
B01AB05
ATC
enoxaparin; parenteral
1.9
7.2
130
812
JN4CD
NOMESCO Finland
Very extensive body CT
3.6
7.0
30
88
CJE20
NOMESCO Finland
Phakoemulsification with implantation of artificial lens in posterior chamber
0.5
6.9
61
1080
ZX090
NOMESCO Finland
Other technic of radiotherapy
4.5
6.8
23
54
D38.1
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Trachea, bronchus and lung
3.8
6.7
27
75
C83.9
ICD-10 Finland
Non-follicular (diffuse) lymphoma, unspecified
22.9
6.7
9
*
C81.9
ICD-10 Finland
Hodgkin lymphoma, unspecified
22.9
6.7
9
*
WZC20
NOMESCO Finland
Multidisciplinary treatment meeting
3.6
6.7
28
81
SPAT1109
SPAT
Analgesia with portable analgesic pump
12.5
6.6
11
9
J38.0
ICD-10 Finland
Paralysis of vocal cords and larynx
8.9
6.6
13
15
1XC02
NOMESCO Finland
NA
10.3
6.6
12
12
A02BC02
ATC
pantoprazole; systemic
1.7
6.5
245
1908
WX404
NOMESCO Finland
Intravenous generell anesthesy
2.1
6.5
72
372
C38.1
ICD-10 Finland
Malignant neoplasm: Anterior mediastinum
70.9
6.4
7
*
GA2CT
NOMESCO Finland
Pleural biopsy with CT guidance
70.9
6.4
7
*
A79
ICPC
Malignancy NOS
6.7
6.4
15
23
GAC96
NOMESCO Finland
Other operation on pleura
+∞
6.3
6
*
C45.7
ICD-10 Finland
Mesothelioma of other sites
+∞
6.3
6
*
GEB30
NOMESCO Finland
Mediastinotomy and excision of lesion
+∞
6.3
6
*
GAC20
NOMESCO Finland
Excision or destruction of lesion of pleura
+∞
6.3
6
*
C38.2
ICD-10 Finland
Malignant neoplasm: Posterior mediastinum
+∞
6.3
6
*
Z2221
NOMESCO Finland
Medical doctor
1.8
6.1
110
681
L03AA14
ATC
lipegfilgrastim; parenteral
6.9
6.1
14
21
D07AC01
ATC
betamethasone; topical
0.5
6.0
53
945
Mortality – FinRegistry
↥This endpoint is excluded from FinRegistry analyses (omitted endpoint).
Relationships between endpoints
↥Index endpoint: C3_HEART_MEDIASTINUM_PLEURA – Malignant neoplasm of heart, mediastinum and pleura
GWS hits: -
This endpoint is excluded from FinRegistry analyses (omitted endpoint).